Papers - Okano, Hideyuki

Musashi 1;An evolutionally conserved marker forCNS progenitor cells including neural stem cells.

Kaneko Yukiko, Imai T, Nakamura Y, Sawamoto K, Ogawa Yuuto, Toyama Yoshiaki, Miyata T, Okano Hideyuki

Developmental Neuroscience 22   139-153 2000

Research paper (scientific journal), Joint Work

Neural stem cells

Okano H.

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 45 ( 13 Suppl ) 2063 - 2077 2000

ISSN  0039-9450

Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death

Hisahara S., Takano R., Shoji S., Okano H., Miura M.

Journal of Neural Transmission, Supplement  ( 58 ) 135 - 142 2000

ISSN  0303-6995

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<p>Oligodendrocytes are myelin forming cells in mammalian central nervous system. About 50% of oligodendrocytes (OLGs) undergo cell death in normal development. In addition, OLG cell deaths have been observed in demyelinating diseases including multiple sclerosis (MS). Clinical observations and in vitro cell culture studies have suggested that cytokines mediate OLG cell damage in multiple sclerosis (MS). Among the cytokines, tumor necrosis factor (TNF) is thought to be one of the mediators responsible for the damage of OLGs in MS. The administration of TNF-α to primary cultures of OLGs induced DNA fragmentation, and significantly decreased the number of live OLGs. Chemical inhibitors Ac-YVAD-CHO (a specific inhibitor of caspase-1 (ICE)-like proteases) enhanced the survival of TNF-α treated OLGs better than Ac-DEVD-CHO (a specific inhibitor of caspase-3 (CPP32)-like proteases). These results indicate that caspase-1-mediated cell-death pathway are activated in TNF-induced OLG cell death. Caspase-11 is involved in activation of caspase-1. Oligodendrocytes from caspase-11-deficient mice are partially resistant to TNF-induced OLG cell death. Our results suggest that the inhibition of caspase-1 sufamily may be a novel therapeutic approach to treat MS.</p>

Neural stem cells

Okano H.

Japanese Journal of Psychopharmacology 20 ( 1 ) 21 - 26 2000

ISSN  1340-2544

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<p>Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications for damaged brain. By understanding the nature of NSCs present in the CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localization of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, it would be possible to develop a feasible strategy to manipulate cells in situ to treat damaged brain.</p>

Neural stem cells

Okano Hideyuki

Clinical Neurology 41 ( 12 ) 1036 - 1040 2001.12

ISSN  0009-918X

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<p>Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications to the damaged brain. By understanding of nature of NSCs present in CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localizations of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, which will be introduced in this review, it would be possible to develop a feasible strategy to manipulate cells in situ to treat the damaged brain.</p>

In vitro selection法によるRNA結合タンパク質の標的配列の同定

Imai Takao，Okano Jiimusuhirotaka，Okano Hideyuki

細胞工学 20 ( 12 ) 1690-1697 2001.12

Research paper (scientific journal), Joint Work

パーキンソン病治療への新たな布石

Sawamoto Kazunobu，Okano Hideyuki

Bio ベンチャー 1 ( 3 ) 90-91 2001.11

Research paper (scientific journal), Joint Work

Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

Yamamoto Naoya, Yamamoto Shin-ichi, Inagaki Fuyuki, Kawaichi Masashi, Fukamizu Akiyoshi, Kishi Noriyuki, Matsuno Kenji, Nakamura Kozo, Weinmaster Gerry, Okano Hideyuki, Nakafuku Masato

Journal of Biological Chemistry 276 ( 48 ) 45031-45040 2001.11

Research paper (scientific journal), Joint Work

再生治療の海外基礎研究開発状況―特に幹細胞生物学研究を中心に

Kanemura Yonehiro，Okano Hideyuki

Science&Technology Jounal 10 ( 00 ) 14-17 2001.11

Research paper (scientific journal), Joint Work

神経幹細胞の同定・分離の確立と神経再生への挑戦

Okano Hideyuki

神経治療学 18 ( 5/6合併号 ) 443-449 2001.11

Research paper (scientific journal), Single Work

神経幹細胞と再生

Imai Takao，Okano Jiimusuhirotaka，Okano Hideyuki

治療学 35   29-35 2001.10

Research paper (scientific journal), Joint Work

RNA-binding protein Musashi2: Developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS

Sakakibara Shin-ich, Nakamura Yuki, Satoh Hitoshi, Okano Hideyuki

Journal of Neuroscince 21 ( 20 ) 8091-8107 2001.10

Research paper (scientific journal), Joint Work

再生医学の基本戦略：中枢神経系を中心として

Okano Hideyuki

KAST Report 13 ( 1 ) 24-29 2001.10

Research paper (scientific journal), Single Work

神経幹細胞：その基礎生物学と高次神経機能・精神神経疾患への応用

Okano Hideyuki

精神神経学雑誌 103 ( 10 ) 759-763 2001.10

Research paper (scientific journal), Single Work

幹細胞システムを用いた中枢神経系の再生医学

Okano Hideyuki

Neurologia medico-chirurgica 41 ( extra issue ) 23 2001.10

Research paper (scientific journal), Single Work

Brain from bone:Efficient'meta-differentiation'of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent

Jun Kohyama, Hitoshi Abe, Takuya Shimazaki, Amane Koizumi, Kin-ichi Nakashima, Satoshi Gojo, Tetsuya Taga, Hideyuki Okano, Jun-ichi Hata, Akihiro Umezawa

Differentiation 68 ( 4-5 ) 235-244 2001.10

Research paper (scientific journal), Joint Work

IP₃ receptor type 1 mRNAの3'末端非翻訳領域に結合する遺伝子産物と小脳purkinje細胞におけるmRNA局在化機構

Iijima Takatoshi，Imai Takao，Kimura Yuuki，Okano Hideyuki

神経化学 40 ( 2,3 (Suppl) ) 311 2001.09

Research paper (scientific journal), Joint Work

An imaging-based 'time-table' of melecular expression in cultured murine neuroepthelial cells

Kawaguchi Ayano, Ogawa Maaharu, Okano Hideyuki, Saito Kaneko, Miyata Takayuki

Neurosciene Research 25 ( Suppl ) S128 2001.09

Research paper (scientific journal), Joint Work

High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain

Keyoung Michael H, Roy Neeta S, Benraiss Abdellatif, Louissaint Abner Jr, Suzuki Akira, Hashimoto Mitsuhiro, Rashbaum William K, Okano Hideyuki, Goldman Steven A

Nature Biotechnology 19 ( 9 ) 843-850 2001.09

Research paper (scientific journal), Joint Work

Asymmetric inheritance of radial glial fibers by cortical neurons

Miyata Takaki, Kawaguchi Ayano, Okano Hideyuki, Ogawa Masaharu

Neuron 31 ( 5 ) 727-741 2001.09

Research paper (scientific journal), Joint Work