Papers - Okano, Hideyuki

Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells

Okada, Yohei, Matsumoto, Arifumi, Shimazaki, Takuya, Enoki, Ryosuke, Koizumi, Amane, Ishii, Seiji, Itoyama, Yasuto, Sobue, Gen, Okano, Hideyuki

STEM CELLS 26 ( 12 ) 3086 - 3098 2008

Research paper (scientific journal),  ISSN  1066-5099

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A factor secreted from bone-marrow-derived endothelial progenitor cells promotes self-renewal of neural stem cells in mice

Namiki, Jun, Suzuki, Sayuri, Matsuzaki, Yumi, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S86 - S86 2008

Research paper (scientific journal),  ISSN  0168-0102

Application of q-space MRI to spinal cord in common marmoset

Hikishima, Keigo, Nakamura, Masaya, Fujiyoshi, Kanehiro, Yamada, Masayuki, Kitamura, Kazuya, Momoshima, Suketaka, Yagi, Kazuo, Tamaoki, Norikazu, Toyama, Yoshiaki, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S277 - S277 2008

Research paper (scientific journal),  ISSN  0168-0102

A novel gamma-secretase inhibitor, LY411575, replaced auditory hair cells and recovered hearing loss after severe acoustic trauma in mice

Fujioka, Masato, Hosoya, Makoto, Wakabayashi, Kenichiro, Jeon, Sang-Jun, Okano, Hirotaka James, Kanzaki, Sho, Ogawa, Kaoru, Edge, Albert, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S25 - S25 2008

Research paper (scientific journal),  ISSN  0168-0102

Proliferation of neural progenitors and induction of reactive glia after brain ischemia detected with Nestin-Cre-ER system

Oki, Koichi, Kanki, Hiroaki, Suzuki, Norihiro, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S133 - S133 2008

Research paper (scientific journal),  ISSN  0168-0102

Neural crest-derived cells in the peripheral olfactory system

Katoh, Hiroyuki, Satoh, Etsuko, Nakamura, Masaya, Nagoshi, Narihito, Toyama, Yoshiaki, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S178 - S178 2008

Research paper (scientific journal),  ISSN  0168-0102

Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

Kurihara, Toshihide, Ozawa, Yoko, Tsubota, Kazuo, Okano, Hideyuki, Ishida, Susumu

NEUROSCIENCE RESEARCH 61   S220 - S220 2008

Research paper (scientific journal),  ISSN  0168-0102

Analysis of transcriptional regulation of musashi1 gene in neural stem cells

Kawase, Satoshi, Imai, Takao, Hara, Chikako, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S152 - S152 2008

Research paper (scientific journal),  ISSN  0168-0102

Comparative study of different administrations of the neural stem cells for spinal cord injury in mice

Takahashi, Yuichiro, Nakamura, Masaya, Tuji, Osahiko, Kumagai, Gentarou, Hara, Chikako, Toyama, Yoshiaki, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S85 - S85 2008

Research paper (scientific journal),  ISSN  0168-0102

In vitro and vivo characterization in human neural stem/progenitor cells expressing ABC transporter ABCB1

Kanemura, Yonehiro, Yamamoto, Atsuyo, Shofuda, Tomoko, Nakamura, Yasuhiro, Okano, Hideyuki, Yamasaki, Mami

NEUROSCIENCE RESEARCH 61   S86 - S86 2008

Research paper (scientific journal),  ISSN  0168-0102

Functional analysis of Hu-associated RNA binding protein-network

Okano, Hirotaka J., Kakumoto, Kyoko, Igarashi, Maria, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S42 - S42 2008

Research paper (scientific journal),  ISSN  0168-0102

The effect of anti-interleukin-6 receptor antibody in noise induced damaged cochlea

Wakabayashi, Kenichiro, Fujioka, Masato, Kanzaki, Sho, Yamashita, Daisuke, Masuda, Masatsugu, Okano, James Hirotaka, Okano, Hideyuki, Ogawa, Kaoru

NEUROSCIENCE RESEARCH 61   S102 - S102 2008

Research paper (scientific journal),  ISSN  0168-0102

The functional analysis of RNA-binding protein Musashi2 in the cerebellum

Kuwako, Kenichiro, Shibata, Shinsuke, Okano, Hirotaka J., Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S89 - S89 2008

Research paper (scientific journal),  ISSN  0168-0102

Investigation of neural crest stem cell therapy for Hirschsprung's disease

Shimojima, Naoki, Morikawa, Yasuhide, Hotta, Ryo, Nagoshi, Narihito, Shibata, Shinsuke, Okano, James Hirotaka, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S36 - S36 2008

Research paper (scientific journal),  ISSN  0168-0102

SOCS3 is required to protect photoreceptor cell function during retinal inflammation

Ozawa, Yoko, Nakao, Keiko, Kurihara, Trishilhide, Shimazaki, Takuya, Shimmura, Shigeto, Ishida, Susumu, Yoshimura, Akihiko, Tsubota, Kazuo, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61   S269 - S269 2008

Research paper (scientific journal),  ISSN  0168-0102

Notch-Hes1 Pathway Contributes to the Cochlear Prosensory Formation Potentially Through the Transcriptional Down-Regulation of p27(Kip1)

Murata, Junko, Ohtsuka, Toshiyuki, Tokunaga, Akinori, Nishiike, Suetaka, Inohara, Hidenori, Okano, Hideyuki, Kageyama, Ryoichiro

JOURNAL OF NEUROSCIENCE RESEARCH 87 ( 16 ) 3521 - 3534 2009.12

Research paper (scientific journal),  ISSN  0360-4012

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Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus)

Sotomaru, Yusuke, Hirakawa, Reiko, Shimada, Akiko, Shiozawa, Seiji, Sugawara, Ayako, Oiwa, Ryo, Nobukiyo, Asako, Okano, Hideyuki, Tamaoki, Norikazu, Nomura, Tatsuji, Hiyama, Eiso, Sasaki, Erika

CLONING AND STEM CELLS 11 ( 4 ) 575 - 583 2009.12

Research paper (scientific journal),  ISSN  1536-2302

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Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset

Yaguchi, Masae, Tabuse, Masanao, Ohta, Shigeki, Ohkusu-Tsukada, Kozo, Takeuchi, Tamaki, Yamane, Junichi, Katoh, Hiroyuki, Nakamura, Masaya, Matsuzaki, Yumi, Yamada, Masayuki, Itoh, Toshio, Nomura, Tatsuji, Toyama, Yoshiaki, Okano, Hideyuki, Toda, Masahiro

NEUROSCIENCE RESEARCH 65 ( 4 ) 384 - 392 2009.12

Research paper (scientific journal),  ISSN  0168-0102

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Neuronal re-juvenilization in the nucleus ambiguus after vagal nerve injury

Takaoka, Takuji, Shiotani, Akihiro, Saito, Koichiro, Tomifuji, Masayuki, Mori, Yuko, Fujimine, Takekatsu, Okano, Hideyuki, Ogawa, Kaoru

NEUROSCIENCE RESEARCH 65 ( 4 ) 353 - 359 2009.12

Research paper (scientific journal),  ISSN  0168-0102

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Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice

Hashimoto H., Arai T., Mori A., Kawai K., Hikishima K., Ohnishi Y., Eto T., Ito M., Hioki K., Suzuki R., Ohsugi M., Saito M., Ueyama Y., Okano H., Yamauchi T., Kubota N., Ueki K., Tobe K., Tamaoki N., Kadowaki T., Kosaka K.

Experimental and Clinical Endocrinology and Diabetes 117 ( 10 ) 577 - 586 2009.11

ISSN  0947-7349

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<p>Current Japanese and American diets and Japanese diet immediately after the War were converted to laboratory animal diets. As a result, current laboratory animal diet (CA-I, CLEA) unexpectedly resembled the diet of Japanese after the War. This is considered to result in an under-evaluation of diabetes research using laboratory animals at present. Therefore, changes in insulin signals caused by current Japanese and American diets were examined using IRS-2 deficient mice (Irs2 ^-/- mice) and mechanisms of aggravation of type 2 diabetes due to modern diets were examined. Irs2 ^-/- mice at 6 weeks of age were divided into three groups: Japanese diet (Jd) group, American diet (Ad) group and CA-I diet [regular diet (Rd)] group. Each diet was given to the dams from 7 days before delivery. When the Irs2 ^-/- mice reached 6 weeks of age, the glucose tolerance test (GTT), insulin tolerance test (ITT) and organ sampling were performed. The sampled organs and white adipose tissue were used for analysis of RNA, enzyme activity and tissues. In GTT and ITT, the Ad group showed worse glucose tolerance and insulin resistance than the Rd group. Impaired glucose tolerance of the Jd group was the same as that of the Rd group, but insulin resistance was worse than in the Rd group. These results were caused an increase in fat accumulation and adipocytes in the peritoneal cavity by lipogenic enzyme activity in the liver and muscle, and the increase in TNFa of hypertrophic adipocyte origin further aggravated insulin resistance and the increase in resistin also aggravated the impaired glucose tolerance, leading to aggravation of type 2 diabetes. The Japanese and American diets given to the Irs2 ^-/- mice, which we developed, showed abnormal findings in some Irs2 ^-/- mice but inhibited excessive reactions of insulin signals as diets used in ordinary nutritional management.</p>

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