Papers - Okano, Hideyuki

Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors

Zhou, Zhi, Kohda, Kazuhisa, Ibata, Keiji, Kohyama, Jun, Akamatsu, Wado, Yuzaki, Michisuke, Okano, Hirotaka James, Sasaki, Erika, Okano, Hideyuki

MOLECULAR BRAIN 7   257 - 267 2014.04

Research paper (scientific journal),  ISSN  1756-6606

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Birth of Healthy Offspring following ICSI in In Vitro-Matured Common Marmoset (Callithrix jacchus) Oocytes

Takahashi, Tsukasa, Hanazawa, Kisaburo, Inoue, Takashi, Sato, Kenya, Sedohara, Ayako, Okahara, Junko, Suemizu, Hiroshi, Yagihashi, Chie, Yamamoto, Masafumi, Eto, Tomoo, Konno, Yusuke, Okano, Hideyuki, Suematsu, Makoto, Sasaki, Erika

PLOS ONE 9 ( 4 ) 3674 - 3686 2014.04

Research paper (scientific journal),  ISSN  1932-6203

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Promise of Human Induced Pluripotent Stem Cells in Skin Regeneration and Investigation

Ohyama, Manabu, Okano, Hideyuki

JOURNAL OF INVESTIGATIVE DERMATOLOGY 134 ( 3 ) 605 - 609 2014.03

Research paper (scientific journal),  ISSN  0022-202X

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Inflammatory cascades mediate synapse elimination in spinal cord compression

Takano, Morito, Kawabata, Soya, Komaki, Yuji, Shibata, Shinsuke, Hikishima, Keigo, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

JOURNAL OF NEUROINFLAMMATION 11   63 - 73 2014.03

Research paper (scientific journal),  ISSN  1742-2094

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iPS cell technologies: significance and applications to CNS regeneration and disease

Okano, Hideyuki, Yamanaka, Shinya

MOLECULAR BRAIN 7   106 - 114 2014.03

Research paper (scientific journal),  ISSN  1756-6606

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Prenatal Deletion of the RNA-Binding Protein HuD Disrupts Postnatal Cortical Circuit Maturation and Behavior

DeBoer, Erik M., Azevedo, Ricardo, Vega, Taylor A., Brodkin, Jesse, Akamatsu, Wado, Okano, Hideyuki, Wagner, George C., Rasin, Mladen-Roko

JOURNAL OF NEUROSCIENCE 34 ( 10 ) 3674 - 3686 2014.03

Research paper (scientific journal),  ISSN  0270-6474

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Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition

Zhang, Liang, Kaneko, Shinjiro, Kikuchi, Kaoru, Sano, Akihiko, Maeda, Miho, Kishino, Akiyoshi, Shibata, Shinsuke, Mukaino, Masahiko, Toyama, Yoshiaki, Liu, Meigen, Kimura, Toru, Okano, Hideyuki, Nakamura, Masaya

MOLECULAR BRAIN 7   8043 - 8052 2014.03

Research paper (scientific journal),  ISSN  1756-6606

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Pharmacological Inhibition of Cochlear Mitochondrial Respiratory Chain Induces Secondary Inflammation in the Lateral Wall: A Potential Therapeutic Target for Sensorineural Hearing Loss

Fujioka, Masato, Okamoto, Yasuhide, Shinden, Seiichi, Okano, Hirotaka James, Okano, Hideyuki, Ogawa, Kaoru, Matsunaga, Tatsuo

PLOS ONE 9 ( 3 ) 163 - 175 2014.03

Research paper (scientific journal),  ISSN  1932-6203

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Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

Bae, Byoung-Il, Tietjen, Ian, Atabay, Kutay D., Evrony, Gilad D., Johnson, Matthew B., Asare, Ebenezer, Wang, Peter P., Murayama, Ayako Y., Im, Kiho, Lisgo, Steven N., Overman, Lynne, Sestan, Nenad, Chang, Bernard S., Barkovich, A. James, Grant, P. Ellen, Topcu, Meral, Politsky, Jeffrey, Okano, Hideyuki, Piao, Xianhua, Walsh, Christopher A.

SCIENCE 343 ( 6172 ) 764 - 768 2014.02

Research paper (scientific journal),  ISSN  0036-8075

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Fetal sulcation and gyrification in common marmosets (Callithrix jacchus) obtained by ex vivo magnetic resonance imaging

Sawada K., Hikishima K., Murayama A. Y., Okano H. J., Sasaki E., Okano H.

Neuroscience 257   158 - 174 2014.01

ISSN  0306-4522

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<p>The present study characterized fetal sulcation patterns and gyrification in the cerebrum of the New World monkey group, common marmosets, using a 3D T₂-weighted high-resolution anatomical magnetic resonance imaging (MRI) sequence from the fixed brain at 7-tesla ex vivo. Fetal sulcation in the marmoset cerebrum began to indent the lateral fissure and hippocampal sulcus in gestational week (GW) 12, and then the following sulci emerged: the callosal and calcarine sulci on GW 15; the superior temporal sulcus on GW 17; and the circular and occipitotemporal sulci on GW 18. The degree of cortical convolution was evaluated quantitatively based on 2D MRI slices by the gyrification index (GI) and based on 3D MRI data by sulcation index (SI). Both the mean GI and SI increased from GW 16, and were closely correlated with the cortical volume and the cortical surface area during fetal periods (their correlation coefficients marked more than 0.95). After birth, both the mean GI and SI decreased slightly by 2years of age, whereas the cortical volume and surface area continuously increased. Notably, histological analysis showed that the outer subventricular zone (oSVZ) in non-sulcal regions was thicker than that in the presumptive calcarine sulcal region on GW 13, preceding the infolding of the calcarine sulcus. The present results showed definite sulcal infolding on the cerebral cortical surface of the marmosets, with similar pattern and sequence of their emergences to other higher-order primates such as macaques and humans. Differential expansion of the oSVZ may be involved in gyral convolution and sulcal infolding in the developing cerebrum. © 2013 IBRO.</p>

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Distinct roles of endogenous vascular endothelial factor receptor 1 and 2 in neural protection after spinal cord injury

Shinozaki Munehisa, Nakamura Masaya, Konomi Tsunehiko, Kobayashi Yoshiomi, Takano Morito, Saito Nobuhito, Toyama Yoshiaki, Okano Hideyuki

Neuroscience Research 78 ( 1 ) 55 - 64 2014.01

ISSN  0168-0102

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<p>Secondary degeneration after spinal cord injury (SCI) is caused by increased vascular permeability, infiltration of inflammatory cells, and subsequent focal edema. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions to reduce cell death and promote tissue regeneration. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor. However, the effect of VEGF on SCI remains controversial. VEGF signaling is primarily regulated through two primary receptors, VEGF receptor 1 (VEGF-R1) and VEGF receptor 2 (VEGF-R2). The purpose of this study was to examine the effects of intraperitoneal administration of VEGF-R1- and VEGF-R2-neutralizing antibodies on a mouse model of SCI. VEGF-R1 blockade, but not VEGF-R2 blockade, decreased the permeability and infiltration of inflammatory cells, and VEGF-R2 blockade caused a significant increase in neuronal apoptosis in the acute phase of SCI. VEGF-R2 blockade decreased the residual tissue area and the number of neural fibers in the chronic phase of SCI. VEGF-R2 blockade worsened the functional recovery and prolonged the latency of motor evoked potentials. These data suggest that endogenous VEGF-R2 plays a crucial role in neuronal protection after SCI. © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society.</p>

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Generation of Germ Cells In Vitro in the Era of Induced Pluripotent Stem Cells

Imamura, Masanori, Hikabe, Orie, Lin, Zachary Yu-Ching, Okano, Hideyuki

MOLECULAR REPRODUCTION AND DEVELOPMENT 81 ( 1 ) 2 - 19 2014.01

Research paper (scientific journal),  ISSN  1040-452X

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Common marmoset as a new model animal for neuroscience research and genome editing technology

Kishi, Noriyuki, Sato, Kenya, Sasaki, Erika, Okano, Hideyuki

DEVELOPMENT GROWTH &amp; DIFFERENTIATION 56 ( 1 ) 53 - 62 2014.01

Research paper (scientific journal),  ISSN  0012-1592

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The miR-17/106-p38 axis is a key regulator of the neurogenic-to-gliogenic transition in developing neural stem/progenitor cells

Naka-Kaneda, Hayato, Nakamura, Shiho, Igarashi, Mana, Aoi, Hisashi, Kanki, Hiroaki, Tsuyama, Jun, Tsutsumi, Shuichi, Aburatani, Hiroyuki, Shimazaki, Takuya, Okano, Hideyuki

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 ( 4 ) 1604 - 1609 2014.01

Research paper (scientific journal),  ISSN  0027-8424

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LIM Homeobox 8 (Lhx8) Is a Key Regulator of the Cholinergic Neuronal Function via a Tropomyosin Receptor Kinase A (TrkA)-mediated Positive Feedback Loop

Tomioka, Takeyasu, Shimazaki, Takuya, Yamauchi, Toshihiko, Oki, Toru, Ohgoh, Makoto, Okano, Hideyuki

JOURNAL OF BIOLOGICAL CHEMISTRY 289 ( 2 ) 1000 - 1010 2014.01

Research paper (scientific journal),  ISSN  0021-9258

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Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia

Bundo, Miki, Toyoshima, Manabu, Okada, Yohei, Akamatsu, Wado, Ueda, Junko, Nemoto-Miyauchi, Taeko, Sunaga, Fumiko, Toritsuka, Michihiro, Ikawa, Daisuke, Kakita, Akiyoshi, Kato, Motoichiro, Kasai, Kiyoto, Kishimoto, Toshifumi, Nawa, Hiroyuki, Okano, Hideyuki, Yoshikawa, Takeo, Kato, Tadafumi, Iwamoto, Kazuya

NEURON 81 ( 2 ) 306 - 313 2014.01

Research paper (scientific journal),  ISSN  0896-6273

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The RNA-binding Protein HuD Regulates Autophagosome Formation in Pancreatic beta Cells by Promoting Autophagy-related Gene 5 Expression

Kim, Chongtae, Kim, Wook, Lee, Heejin, Ji, Eunbyul, Choe, Yun-Jeong, Martindale, Jennifer L., Akamatsu, Wado, Okano, Hideyuki, Kim, Ho-Shik, Nam, Suk Woo, Gorospe, Myriam, Lee, Eun Kyung

JOURNAL OF BIOLOGICAL CHEMISTRY 289 ( 1 ) 112 - 121 2014.01

Research paper (scientific journal),  ISSN  0021-9258

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Role of opioid systems in the differentiation potential of pluripotent stem cells

Kuzumaki, Naoko, Yamamizu, Kohei, Okano, Hideyuki, Narita, Minoru

JOURNAL OF PHARMACOLOGICAL SCIENCES 124   52P - 52P 2014

Research paper (scientific journal),  ISSN  1347-8613

Transplantation of Neural Stem/Progenitor Cells at Different Locations in Mice With Spinal Cord Injury

Iwai, Hiroki, Nori, Satoshi, Nishimura, Soraya, Yasuda, Akimasa, Takano, Morito, Tsuji, Osahiko, Fujiyoshi, Kanehiro, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

CELL TRANSPLANTATION 23 ( 11 ) 1451 - 1464 2014

Research paper (scientific journal),  ISSN  0963-6897

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Micro-RNA 200b/429 in the nucleus accumbens plays a key role in the neuropathic pain

Hamada, Asami, Yamashita, Akira, Suhara, Yuki, Narita, Michiko, Tsuyama, Jun, Kuzumaki, Naoko, Okano, Hideyuki, Narita, Minoru

JOURNAL OF PHARMACOLOGICAL SCIENCES 124   101P - 101P 2014

Research paper (scientific journal),  ISSN  1347-8613