Papers - Okano, Hideyuki

Strategies toward CNS-Regeneration using iPS cell technology

Okano, Hideyuki

JOURNAL OF PHARMACOLOGICAL SCIENCES 112   28P - 28P 2010

Research paper (scientific journal),  ISSN  1347-8613

Multiple expression analysis of neurotransmittor under embryonic stem cell differentiation

Narita, Minoru, Kuzumaki, Naoko, Narita, Michiko, Imai, Satoshi, Okano, Hideyuki, Suzuki, Tsutomu

JOURNAL OF PHARMACOLOGICAL SCIENCES 112   28P - 28P 2010

Research paper (scientific journal),  ISSN  1347-8613

Investigating the roles of purinergic signaling in adult neurogenesis

Suyama, Satoshi, Sunabori, Takehiko, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E367 - E367 2010

Research paper (scientific journal),  ISSN  0168-0102

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Drug discovery using human neurons derived from iPS cells

Adachi, Keiko, Nakamura, Koji, Asami-Odaka, Asano, Okada, Yohei, Okano, Hideyuki, Nakanishi, Atsushi

NEUROSCIENCE RESEARCH 68   E134 - E135 2010

Research paper (scientific journal),  ISSN  0168-0102

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Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Okano, Hirotaka J., Tada, Hirobumi, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E60 - E60 2010

Research paper (scientific journal),  ISSN  0168-0102

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Combining extensive treadmill training with a selective semaphorin3A inhibitor treatment enhances locomotor functional recovery by wiring regenerated axons in adult spinal cord-transected rats

Zhang, Liang, Kaneko, Shinjiro, Sano, Akihiko, Maeda, Miho, Kishino, Akiyoshi, Mukaino, Masahiko, Toyama, Yoshiaki, Liu, Meigen, Nakamura, Masaya, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E259 - E260 2010

Research paper (scientific journal),  ISSN  0168-0102

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Development and analysis of less invasive transient middle cerebral artery occlusion model on Common Marmoset

Hara, Koichi, Muto, Jun, Kaneko, Naoko, Adachi, Kazuhide, Toyota, Fumika, Hikishima, Keigo, Itoh, Toshio, Sawamoto, Kazunobu, Kawase, Takeshi, Yoshida, Kazunari, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E320 - E320 2010

Research paper (scientific journal),  ISSN  0168-0102

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Galectin-1 is expressed in early type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus

Imaizumi, Yoichi, Sakaguchi, Masanori, Morishita, Tsuyoshi, Ito, Mamoru, Poirier, Francoise, Sawamoto, Kazunobu, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E365 - E365 2010

Research paper (scientific journal),  ISSN  0168-0102

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In silico analysis of hnRNP K binding sites in p21 mRNA

Igarashi, Mana, Nakamura, Shingo, Kinoshita, Mika, Okano, Hirotaka J., Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E354 - E354 2010

Research paper (scientific journal),  ISSN  0168-0102

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Planar cell polarity of multiciliated ependymal cells regulated by non-muscle myosin II

Hirota, Yuki, Meunier, Alice, Huang, Shihhui, Shimozawa, Togo, Kida, Yasuyuki S., Inoue, Masashi, Ito, Tsubasa, Kato, Hiroko, Nakaya, Masa-aki, Nonaka, Shigenori, Ogura, Toshihiko, Higuchi, Hideo, Okano, Hideyuki, Spassky, Nathalie, Sawamoto, Kazunobu

NEUROSCIENCE RESEARCH 68   E364 - E364 2010

Research paper (scientific journal),  ISSN  0168-0102

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Role of G-protein coupled receptors in the neural differentiation from embryonic stem cells

Kuzumaki, Naoko, Suzuki, Atsuo, Narita, Michiko, Imai, Satoshi, Okada, Yohei, Okano, James Hirotaka, Okano, Hideyuki, Suzuki, Tsutomu, Narita, Minoru

NEUROSCIENCE RESEARCH 68   E134 - E134 2010

Research paper (scientific journal),  ISSN  0168-0102

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New neurons form and maintain their path of astrocytic processes for rapid migration in the adult brain

Kaneko, Naoko, Marin, Oscar, Koike, Masato, Hirota, Yuki, Uchiyama, Yasuo, Wu, Jane Y., Lu, Qiang, Tessier-Lavigne, Marc, Alvarez-Buylla, Arturo, Okano, Hideyuki, Rubenstein, John L. R., Sawamoto, Kazunobu

NEUROSCIENCE RESEARCH 68   E93 - E93 2010

Research paper (scientific journal),  ISSN  0168-0102

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Implication of monoamines and neuropeptides in embryogenesisis and neurogenesis

Yajima, Marie, Kuzumaki, Naoko, Narita, Minoru, Narita, Michiko, Imai, Satoshi, Furuta, Sadayoshi, Suzuki, Atsuo, Miyashita, Kazuhiko, Tsukiji, Kozue, Okada, Yohei, Okano, J. Hirotaka, Okano, Hideyuki, Suzuki, Tsutomu

JOURNAL OF PHARMACOLOGICAL SCIENCES 112   70P - 70P 2010

Research paper (scientific journal),  ISSN  1347-8613

Transplantation of human embryonic stem cell derived-neural stem/progenitor cells for spinal cord injury in adult NOD/Scid mice

Takahashi, Yuichiro, Okada, Youhei, Kumagai, Gentarou, Tsuji, Osahiko, Nori, Satoshi, Yasuda, Akimasa, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E425 - E425 2010

Research paper (scientific journal),  ISSN  0168-0102

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Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, Takuya, Ito, Daisuke, Okada, Yohei, Akamatsu, Wado, Nihei, Yoshihiro, Yoshizaki, Takahito, Yamanaka, Shinya, Okano, Hideyuki, Suzuki, Norihiro

HUMAN MOLECULAR GENETICS 20 ( 23 ) 4530 - 4539 2011.12

Research paper (scientific journal),  ISSN  0964-6906

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Generation of Stratified Squamous Epithelial Progenitor Cells from Mouse Induced Pluripotent Stem Cells

Yoshida, Satoru, Yasuda, Miyuki, Miyashita, Hideyuki, Ogawa, Yoko, Yoshida, Tetsu, Matsuzaki, Yumi, Tsubota, Kazuo, Okano, Hideyuki, Shimmura, Shigeto

PLOS ONE 6 ( 12 ) S89 - S89 2011.12

Research paper (scientific journal),  ISSN  1932-6203

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Significance of Remyelination by Neural Stem/Progenitor Cells Transplanted into the Injured Spinal Cord

Yasuda, Akimasa, Tsuji, Osahiko, Shibata, Shinsuke, Nori, Satoshi, Takano, Morito, Kobayashi, Yoshiomi, Takahashi, Yuichiro, Fujiyoshi, Kanehiro, Hara, Chikako Miyauchi, Miyawaki, Atsuhi, Okano, Hirotaka James, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

STEM CELLS 29 ( 12 ) 1983 - 1994 2011.12

Research paper (scientific journal),  ISSN  1066-5099

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Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production

Fukuda H., Mochizuki S., Abe H., Okano H. J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D'Armiento J., Okada Y.

British Journal of Cancer 105 ( 10 ) 1615 - 1624 2011.11

ISSN  0007-0920

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<p>Background: Although matrix metalloproteinases (MMPs) are implicated in tumourigenesis and cancer progression, the role of MMP-13 in melanoma cell metastases is poorly understood. Methods: Lung metastases of mouse melanoma B16BL6 cells were analysed in MMP-13 knockout (KO) and wild-type (WT) mice after intravenous injection. The mRNA and protein expression of MMP-13 in lung tissues was analysed by RT-PCR, real-time PCR, immunoblotting and immunohistochemistry. The expression of SDF-1α, CXCR4 and endostatin, and effects of endostatin to cultured melanoma cells and lung metastases were also studied. Results: Lung metastases of B16BL6 cells were significantly higher by 2.5-5.7-fold in MMP-13 KO mice than in WT mice. The expression of MMP-13 in WT mouse lung tissue was stimulated on day 1 after intravenous injection of the melanoma cells and MMP-13 was immunolocalised to vascular endothelial cells in the lungs. Endostatin formation, but not degradation of SDF-1α, in the lung tissue was associated with reduced lung metastasis in WT mice. Endostatin significantly inhibited migration of B16BL6 cells in monolayer wounding assay and remarkably suppressed Matrigel invasion and transendothelial invasion of the cells. In addition, lung metastases of melanoma cells in MMP-13 KO mice were reduced by intraperitoneal administration of endostatin. Conclusion: Our results suggest that MMP-13 is overproduced by endothelial cells in the lungs with melanoma cells and has a protective role in lung metastasis by local generation of endostatin. © 2011 Cancer Research UK All rights reserved.</p>

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Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury

Kitamura, Kazuya, Fujiyoshi, Kanehiro, Yamane, Jun-ichi, Toyota, Fumika, Hikishima, Keigo, Nomura, Tatsuji, Funakoshi, Hiroshi, Nakamura, Toshikazu, Aoki, Masashi, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

PLOS ONE 6 ( 11 ) 3521 - 3534 2011.11

Research paper (scientific journal),  ISSN  1932-6203

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IN VITRO CHEMOSENSITIVITY OF HUMAN GLIOMA STEM CELLS COMPARED WITH THAT OF NEURAL STEM CELLS FROM HUMAN IPS CELLS

Kanemura, Yonehiro, Shofuda, Tomoko, Kanematsu, Daisuke, Matsumoto, Yukako, Yamamoto, Atsuyo, Nonaka, Masahiro, Moriuchi, Shusuke, Nakajima, Shin, Suemizu, Hiroshi, Nakamura, Masato, Okada, Yohei, Okano, Hideyuki, Yamasaki, Mami

NEURO-ONCOLOGY 13   146 - 146 2011.11

Research paper (scientific journal),  ISSN  1522-8517