Papers - Okano, Hideyuki

Implication of monoamines and neuropeptides in embryogenesisis and neurogenesis

Yajima, Marie, Kuzumaki, Naoko, Narita, Minoru, Narita, Michiko, Imai, Satoshi, Furuta, Sadayoshi, Suzuki, Atsuo, Miyashita, Kazuhiko, Tsukiji, Kozue, Okada, Yohei, Okano, J. Hirotaka, Okano, Hideyuki, Suzuki, Tsutomu

JOURNAL OF PHARMACOLOGICAL SCIENCES 112   70P - 70P 2010

Research paper (scientific journal),  ISSN  1347-8613

Transplantation of human embryonic stem cell derived-neural stem/progenitor cells for spinal cord injury in adult NOD/Scid mice

Takahashi, Yuichiro, Okada, Youhei, Kumagai, Gentarou, Tsuji, Osahiko, Nori, Satoshi, Yasuda, Akimasa, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E425 - E425 2010

Research paper (scientific journal),  ISSN  0168-0102

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"Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins

Kanki, Hiroaki, Shimabukuro, Marilia Kimie, Miyawaki, Atsushi, Okano, Hideyuki

MOLECULAR BRAIN 3   S230 - S230 2010

Research paper (scientific journal),  ISSN  1756-6606

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Generation of induced pluripotent stem cells from patients with schizophrenia

Horiuchi, Yasue, Ishii, Seiji, Kano, Shin-ichi, Ishizuka, Koko, Okada, Yohei, Colantuoni, Carlo, Valle, David, Cascella, Nicola G., Akamatsu, Wado, Sawa, Akira, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E314 - E314 2010

Research paper (scientific journal),  ISSN  0168-0102

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Analysis of molecular mechanism underlying the control of ES cell differentiation by the stimulation of dopamine receptors located on embryonic stem cells

Suzuki, Atsuo, Kuzumaki, Naoko, Narita, Michiko, Imai, Satoshi, Okada, Yohei, Okano, James Hirotaka, Okano, Hideyuki, Suzuki, Tsutomu, Narita, Minoru

NEUROSCIENCE RESEARCH 68   E134 - E134 2010

Research paper (scientific journal),  ISSN  0168-0102

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New aspects on the migration and differentiation of neural crest stem cells

Shibata, Shinsuke, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E39 - E39 2010

Research paper (scientific journal),  ISSN  0168-0102

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Strategies toward regeneration of damaged CNS using iPS cells

Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E53 - E53 2010

Research paper (scientific journal),  ISSN  0168-0102

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Agenetic approach for the organization and function of the blood brain barrier in Drosophila

Kanda, Hiroshi, Shimamura, Rieko, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E57 - E57 2010

Research paper (scientific journal),  ISSN  0168-0102

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Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells

Ohta, Shigeki, Kawakami, Yutaka, Okano, Hideyuki, Toda, Masahiro

NEUROSCIENCE RESEARCH 68   E245 - E246 2010

Research paper (scientific journal),  ISSN  0168-0102

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Touch and pain receptive network formation with RNA binding protein Musashi2 and Pleiotrophin

Okano, Hideyuki, Sakakibara, Shin-ichi, Furue, Hidemasa, Yoshimura, Megumu, Okano, Hirotaka J., Shibata, Shinsuke

NEUROSCIENCE RESEARCH 68   E161 - E161 2010

Research paper (scientific journal),  ISSN  0168-0102

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Comparison of the neural crest stem cell characteristics derived from dorsal root ganglia, whisker pad and bone marrow in neonate rodents

Sato, Momoka, Shibata, Shinsuke, Nagoshi, Narihito, Yasuda, Akimasa, Naka-Kaneda, Hayato, Suzuki, Sadafumi, Mabuchi, Yo, Matsuzaki, Yumi, Nakamura, Masaya, Toyama, Yoshiaki, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E129 - E129 2010

Research paper (scientific journal),  ISSN  0168-0102

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Role and mechanisms of reactive astrocytes? Migration after spinal cord injury

Renault-Mihara, Francois, Mukaino, Masahiko, Shinozaki, Munehisa, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

NEUROSCIENCE RESEARCH 68   E242 - E243 2010

Research paper (scientific journal),  ISSN  0168-0102

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Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes

Shibata, Shinsuke, Yasuda, Akimasa, Renault-Mihara, Francois, Suyama, Satoshi, Katoh, Hiroyuki, Inoue, Takayoshi, Inoue, Yukiko U., Nagoshi, Narihito, Sato, Momoka, Nakamura, Masaya, Akazawa, Chihiro, Okano, Hideyuki

MOLECULAR BRAIN 3   2127 - 2128 2010

Research paper (scientific journal),  ISSN  1756-6606

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The common marmoset as a model system for neuroscience

Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 60   S28 - S28 2010

Research paper (scientific journal),  ISSN  1880-6546

Modeling familial Alzheimer's disease with induced pluripotent stem cells

Yagi, Takuya, Ito, Daisuke, Okada, Yohei, Akamatsu, Wado, Nihei, Yoshihiro, Yoshizaki, Takahito, Yamanaka, Shinya, Okano, Hideyuki, Suzuki, Norihiro

HUMAN MOLECULAR GENETICS 20 ( 23 ) 4530 - 4539 2011.12

Research paper (scientific journal),  ISSN  0964-6906

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Generation of Stratified Squamous Epithelial Progenitor Cells from Mouse Induced Pluripotent Stem Cells

Yoshida, Satoru, Yasuda, Miyuki, Miyashita, Hideyuki, Ogawa, Yoko, Yoshida, Tetsu, Matsuzaki, Yumi, Tsubota, Kazuo, Okano, Hideyuki, Shimmura, Shigeto

PLOS ONE 6 ( 12 ) S89 - S89 2011.12

Research paper (scientific journal),  ISSN  1932-6203

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Significance of Remyelination by Neural Stem/Progenitor Cells Transplanted into the Injured Spinal Cord

Yasuda, Akimasa, Tsuji, Osahiko, Shibata, Shinsuke, Nori, Satoshi, Takano, Morito, Kobayashi, Yoshiomi, Takahashi, Yuichiro, Fujiyoshi, Kanehiro, Hara, Chikako Miyauchi, Miyawaki, Atsuhi, Okano, Hirotaka James, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

STEM CELLS 29 ( 12 ) 1983 - 1994 2011.12

Research paper (scientific journal),  ISSN  1066-5099

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Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production

Fukuda H., Mochizuki S., Abe H., Okano H. J., Hara-Miyauchi C., Okano H., Yamaguchi N., Nakayama M., D'Armiento J., Okada Y.

British Journal of Cancer 105 ( 10 ) 1615 - 1624 2011.11

ISSN  0007-0920

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<p>Background: Although matrix metalloproteinases (MMPs) are implicated in tumourigenesis and cancer progression, the role of MMP-13 in melanoma cell metastases is poorly understood. Methods: Lung metastases of mouse melanoma B16BL6 cells were analysed in MMP-13 knockout (KO) and wild-type (WT) mice after intravenous injection. The mRNA and protein expression of MMP-13 in lung tissues was analysed by RT-PCR, real-time PCR, immunoblotting and immunohistochemistry. The expression of SDF-1α, CXCR4 and endostatin, and effects of endostatin to cultured melanoma cells and lung metastases were also studied. Results: Lung metastases of B16BL6 cells were significantly higher by 2.5-5.7-fold in MMP-13 KO mice than in WT mice. The expression of MMP-13 in WT mouse lung tissue was stimulated on day 1 after intravenous injection of the melanoma cells and MMP-13 was immunolocalised to vascular endothelial cells in the lungs. Endostatin formation, but not degradation of SDF-1α, in the lung tissue was associated with reduced lung metastasis in WT mice. Endostatin significantly inhibited migration of B16BL6 cells in monolayer wounding assay and remarkably suppressed Matrigel invasion and transendothelial invasion of the cells. In addition, lung metastases of melanoma cells in MMP-13 KO mice were reduced by intraperitoneal administration of endostatin. Conclusion: Our results suggest that MMP-13 is overproduced by endothelial cells in the lungs with melanoma cells and has a protective role in lung metastasis by local generation of endostatin. © 2011 Cancer Research UK All rights reserved.</p>

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Human Hepatocyte Growth Factor Promotes Functional Recovery in Primates after Spinal Cord Injury

Kitamura, Kazuya, Fujiyoshi, Kanehiro, Yamane, Jun-ichi, Toyota, Fumika, Hikishima, Keigo, Nomura, Tatsuji, Funakoshi, Hiroshi, Nakamura, Toshikazu, Aoki, Masashi, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

PLOS ONE 6 ( 11 ) 3521 - 3534 2011.11

Research paper (scientific journal),  ISSN  1932-6203

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IN VITRO CHEMOSENSITIVITY OF HUMAN GLIOMA STEM CELLS COMPARED WITH THAT OF NEURAL STEM CELLS FROM HUMAN IPS CELLS

Kanemura, Yonehiro, Shofuda, Tomoko, Kanematsu, Daisuke, Matsumoto, Yukako, Yamamoto, Atsuyo, Nonaka, Masahiro, Moriuchi, Shusuke, Nakajima, Shin, Suemizu, Hiroshi, Nakamura, Masato, Okada, Yohei, Okano, Hideyuki, Yamasaki, Mami

NEURO-ONCOLOGY 13   146 - 146 2011.11

Research paper (scientific journal),  ISSN  1522-8517