Details of a Researcher - Okano, Hideyuki

Papers - Okano, Hideyuki

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Hzf regulates adipogenesis through translational control of C/EBP alpha

Kawagishi, Hiroyuki, Wakoh, Takeshi, Uno, Hatsume, Maruyama, Mitsuo, Moriya, Ayako, Morikawa, Satoru, Okano, Hideyuki, Sherr, Charles J., Takagi, Masatoshi, Sugimoto, Masataka

EMBO JOURNAL 27 ( 10 ) 1481 - 1490 2008.05

Research paper (scientific journal), ISSN 0261-4189

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Role of IL-6 in regulation of inflammation and stem cell differentiation in CNS trauma

Mukaino Masahiko, Nakamura Masaya, Okada Seiji, Toyama Yoshiaki, Liu Meigen, Okano Hideyuki

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 31 ( 2 ) 93 - 98 2008.04

ISSN 0911-4300

<p>Interleukin-6 (IL-6) has been demonstrated to play a pivotal role in CNS trauma as a proinflammatory cytokine which regulates inflammatory response. Not only being a mediator of inflammation, but IL-6 induces neural stem/progenitor cells to undergo astrocytic differentiation selectively in the injured CNS. These effects are considered to coordinate to prevent the CNS repair after traumatic injury. Consistently, we previously reported that the administration of anti-IL-6 receptor antibody (MR16-1) immediately after spinal cord injury in mice decreased the number of invading inflammatory cells and the severity of connective tissue scar formation, and led to improved functional recovery. These findings suggest that neutralization of IL-6 signaling in the acute phase of SCI will be beneficial for CNS repair. A critical merit of this anti-IL-6 receptor antibody is that humanized antibody to human IL-6 receptor (MRA; Atlizumab) has already been reshaped. However, there are several studies which show beneficial aspects of IL-6 signaling in the pathology of CNS trauma. Further investigation of the mechanisms how MR16-1 reduces tissue damage should be required for clinical application.</p>

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Isolation and characterization of dendritic cells from common marmosets for preclinical cell therapy studies

Ohta, Shigeki, Ueda, Yoko, Yaguchi, Masae, Matsuzaki, Yumi, Nakamura, Masaya, Toyama, Yoshiaki, Tanioka, Yoshikuni, Tamaoki, Norikazu, Nomura, Tatsuji, Okano, Hideyuki, Kawakami, Yutaka, Toda, Masahiro

IMMUNOLOGY 123 ( 4 ) 566 - 574 2008.04

Research paper (scientific journal), ISSN 0019-2805

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Spatial gradient effects of 120 mT static magnetic field on endothelial tubular formation in vitro

Okano, Hideyuki, Tomita, Naohide, Ikada, Yoshito

BIOELECTROMAGNETICS 29 ( 3 ) 233 - 236 2008.04

Research paper (scientific journal), ISSN 0197-8462

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M-numb and notch signals are the key factors for gastric mucosal regeneration after acute damage

Takahashi, Tetsufumi, Suzuki, Hidekazu, Saito, Yoshimasa, Masaoka, Tatsuhiro, Nagata, Hiroshi, Matsuzaki, Yumi, Okano, Hideyuki, Hibi, Toshifumi

GASTROENTEROLOGY 134 ( 4 ) A235 - A235 2008.04

Research paper (scientific journal), ISSN 0016-5085

Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors

Sunabori, Takehiko, Tokunaga, Akinori, Nagai, Takeharu, Sawamoto, Kazunobu, Okabe, Masaru, Miyawaki, Atsushi, Matsuzaki, Yumi, Miyata, Takaki, Okano, Hideyuki

JOURNAL OF CELL SCIENCE 121 ( 8 ) 1204 - 1212 2008.04

Research paper (scientific journal), ISSN 0021-9533

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Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad

Nagoshi, Narihito, Shibata, Shinsuke, Kubota, Yoshiaki, Nakarnura, Masaya, Nagai, Yasuo, Satoh, Etsuko, Morikawa, Satoru, Okada, Yohei, Mabuchi, Yo, Katoh, Hiroyuki, Okada, Seiji, Fukuda, Keiichi, Suda, Toshio, Matsuzaki, Yumi, Toyama, Yoshiaki, Okano, Hideyuki

CELL STEM CELL 2 ( 4 ) 392 - 403 2008.04

Research paper (scientific journal), ISSN 1934-5909

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[Mammalian neural stem cells].

Shimazaki Takuya, Okano Hideyuki

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53 ( 4 Suppl ) 311 - 317 2008.03

ISSN 0039-9450

Enhanced transfection efficiency in laser-induced stress wave-assisted gene transfer at low laser fluence by increasing pressure impulse

Takano, Shinta, Sato, Shunichi, Terakawa, Mitsuhiro, Asida, Hiroshi, Okano, Hideyuki, Obara, Minoru

APPLIED PHYSICS EXPRESS 1 ( 3 ) S89 - S89 2008.03

Research paper (scientific journal), ISSN 1882-0778

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[Strategies for axonal regeneration after spinal cord injury].

Kitamura Kazuya, Nakamura Masaya, Toyama Yoshiaki, Okano Hideyuki

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53 ( 4 Suppl ) 411 - 417 2008.03

ISSN 0039-9450

Helicobacter pylori infection induces candidate stem cell marker musashi-1 in the human gastric epithelium

Murata, Hiroaki, Tsuji, Shingo, Tsujii, Masahiko, Nakamura, Toru, Fu, Hai Ying, Eguchi, Hiroshi, Asahi, Kayoko, Okano, Hideyuki, Kawano, Sunao, Hayashi, Norio

DIGESTIVE DISEASES AND SCIENCES 53 ( 2 ) 363 - 369 2008.02

Research paper (scientific journal), ISSN 0163-2116

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The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival

Valentin-Vega Y. A., Okano H., Lozano G.

Cell Death and Differentiation 15 ( 11 ) 1772 - 1781 2008

ISSN 1350-9047

<p>Mdm2 is the major inhibitor of the p53 tumor suppressor. Loss of Mdm2 in mice or in specific tissues of the mouse always yields p53-dependent lethal phenotypes. However, the role of Mdm2 in tissues with high turnover capacity is unknown. We have engineered mice lacking Mdm2 in the intestinal epithelium using the Cre/LoxP system. Loss of Mdm2 (Mdm2^intΔ) results in viable animals, but neonates display multiple intestinal abnormalities such as hyperplasia, enterocyte vacuolization, and inflammation. These defects correlate with a drastic increase in p53-dependent apoptosis in highly proliferative and differentiated cells. Unexpectedly, the observed phenotypes disappear with age. The tissue selects against Mdm2-null cells and increases its proliferative capacity. Additionally, the intestinal stem and progenitor cell populations are enriched leading to an increase in crypt fission events. Enhanced proliferation is achieved by activation of the canonical Wnt and EGFR-mediated Ras/MAPK pathways. While Mdm2 is a critical inhibitor of p53 in the intestinal epithelium, the tissue employs a series of processes that compensate for cell death.</p>

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Analysis of inner ear-selective cis-regulatory enhancer of Sox21 gene

Nakagawa, Fumiko, Fujioka, Masato, Hosoya, Makoto, Hayashi, Ken, Okano, Hirotaka J., Edge, Albert, Okano, Hideyuki

NEUROSCIENCE RESEARCH 61 S103 - S103 2008