Papers - Okano, Hideyuki

STAT3: Down the R(h)oAd

Renault-Mihara F, Okano H

Cytokine (Cytokine)  102   149 - 150 2017

ISSN  10434666

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STAT3-regulated RhoA drives reactive astrocyte dynamics

Renault-Mihara F, Okano H

Cell Cycle  2017

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Plasticity and regeneration in the injured spinal cord after cell transplantation therapy

Nori S., Nakamura M., Okano H.

Progress in Brain Research  2017

ISSN  0079-6123

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<p>Spinal cord injury (SCI) typically damages the long axonal tracts of the spinal cord which results in permanent disability. However, regeneration of the injured spinal cord is approaching reality according to the advances in stem cell biology. Cell transplantation therapy holds potential to lead to recovery following SCI through some positive mechanisms. Grafted cells induce plasticity and regeneration in the injured spinal cord by promoting remyelination of damaged axons, reconstruction of neural circuits by synapse formation between host neurons and graft-derived neurons, and secreting neurotrophic factors to promote axonal elongation as well as reduce retrograde axonal degeneration. In this review, we will delineate (1) the microenvironment of the injured spinal cord that influence the plasticity and regeneration capacity after SCI, (2) a number of different kinds of cell transplantation therapies for SCI that has been extensively studied by researchers, and (3) potential mechanisms of grafted cell-induced regeneration and plasticity in the injured spinal cord.</p>

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RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis

Sato Ryo, Nakano Teppei, Hosonaga Mari, Sampetrean Oltea, Harigai Ritsuko, Sasaki Takashi, Koya Ikuko, Okano Hideyuki, Kudoh Jun, Saya Hideyuki, Arima Yoshimi

BioMed Research International 2017 2017

ISSN  2314-6133

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<p>Metastasis is the main cause of treatment failure and death in cancer patients. Metastasis of tumor cells to the brain occurs frequently in individuals with breast cancer, non-small cell lung cancer, or melanoma. Despite recent advances in our understanding of the causes and in the treatment of primary tumors, the biological and molecular mechanisms underlying the metastasis of cancer cells to the brain have remained unclear. Metastasizing cancer cells interact with their microenvironment in the brain to establish metastases. We have now developed mouse models of brain metastasis based on intracardiac injection of human breast cancer or melanoma cell lines, and we have performed RNA sequencing analysis to identify genes in mouse brain tissue and the human cancer cells whose expression is associated specifically with metastasis. We found that the expressions of the mouse genes Tph2, Sspo, Ptprq, and Pole as well as those of the human genes CXCR4, PLLP, TNFSF4, VCAM1, SLC8A2, and SLC7A11 were upregulated in brain tissue harboring metastases. Further characterization of such genes that contribute to the establishment of brain metastases may provide a basis for the development of new therapeutic strategies and consequent improvement in the prognosis of cancer patients.</p>

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Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe.

OKANO HIDEYUKI

Journal of Neuroscience Methods 1 ( 274 ) 38 - 48 2016.10

Joint Work

Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases.

OKANO HIDEYUKI

Molecular Brain  2016.09

Joint Work

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Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.

OKANO HIDEYUKI

Molecular and Cellular Endocrinology  2016.09

Joint Work

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Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury.

OKANO HIDEYUKI

Stem Cell Reports  2016.09

Joint Work

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Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.

OKANO HIDEYUKI

SCIENTIFIC REPORTS 22 ( 6 ) 33861 2016.09

Joint Work

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

OKANO HIDEYUKI

PLoS One 20 ( 11(9) ) e0163466 2016.09

Joint Work

Worldwide initiatives to advance brain research.

OKANO HIDEYUKI

Nature Neuroscience 26 ( 19(9) ) 1118 - 1122 2016.08

Joint Work

Neural changes in the primate brain correlated with the evolution of complex motor skills.

OKANO HIDEYUKI

SCIENTIFIC REPORTS 8 ( 6 ) 31084 2016.08

Research paper (scientific journal), Joint Work

Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.

OKANO HIDEYUKI

Neuroscience Research  2016.08

Research paper (scientific journal), Joint Work

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Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury.

OKANO HIDEYUKI

SCIENTIFIC REPORTS 3 ( 6 ) 30898 2016.08

Research paper (scientific journal), Joint Work

Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea.

OKANO HIDEYUKI

Neuroreport 3 ( 27(11) ) 833 - 836 2016.08

Research paper (scientific journal)

SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.

OKANO HIDEYUKI

nature genetics 48(7)   792 - 797 2016.07

Research paper (scientific journal)

Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.

OKANO HIDEYUKI

BioMedCentral 27 ( 16 ) 548 2016.07

Research paper (scientific journal), Joint Work

In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.

OKANO HIDEYUKI

Molecular Brain 19 ( 9(1) ) 70 2016.07

Research paper (scientific journal), Joint Work

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.

OKANO HIDEYUKI

Cell Stem Cell 7 ( 19(1) ) 127 - 138 2016.07

Research paper (scientific journal), Joint Work

Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field.

OKANO HIDEYUKI

Neuroscience Research 107   20 - 29 2016.06

Research paper (scientific journal)