Papers - Okano, Hideyuki

RNA-binding protein Qki5 regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling

Hayakawa-Yano Y, Suyama S, Nogami M, Yugami M, Koya I, Furukawa T, Zhou L,Abe M, Sakimura K, Takebayashi H, Nakanishi A, Okano H*, and Yano M.*

Genes & Dev  2017

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Assessment of Mitophagy in iPS Cell-Derived Neurons

Ishikawa KI, Yamaguchi A, Okano H, Akamatsu W

Methods Mol Biol (Methods in Molecular Biology)  1759   59 - 67 2017

ISSN  10643745

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© 2017, Springer Science+Business Media New York. Aberrant mitochondrial function is associated with many neurological diseases. Mitophagy is a key mechanism for the elimination of damaged mitochondria and maintenance of mitochondrial homeostasis. Induced pluripotent stem (iPS) cell technologies developed over the last decade have allowed us to analyze functions of the human neuron. Here we describe an efficient induction method from human iPS cells to neurons, followed by an image-based mitophagy assay.

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STAT3: Down the R(h)oAd

Renault-Mihara F, Okano H

Cytokine (Cytokine)  102   149 - 150 2017

ISSN  10434666

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STAT3-regulated RhoA drives reactive astrocyte dynamics

Renault-Mihara F, Okano H

Cell Cycle  2017

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Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe.

OKANO HIDEYUKI

Journal of Neuroscience Methods 1 ( 274 ) 38 - 48 2016.10

Joint Work

Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases.

OKANO HIDEYUKI

Molecular Brain  2016.09

Joint Work

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Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.

OKANO HIDEYUKI

Molecular and Cellular Endocrinology  2016.09

Joint Work

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Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury.

OKANO HIDEYUKI

Stem Cell Reports  2016.09

Joint Work

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Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.

OKANO HIDEYUKI

SCIENTIFIC REPORTS 22 ( 6 ) 33861 2016.09

Joint Work

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

OKANO HIDEYUKI

PLoS One 20 ( 11(9) ) e0163466 2016.09

Joint Work

Worldwide initiatives to advance brain research.

OKANO HIDEYUKI

Nature Neuroscience 26 ( 19(9) ) 1118 - 1122 2016.08

Joint Work

Neural changes in the primate brain correlated with the evolution of complex motor skills.

OKANO HIDEYUKI

SCIENTIFIC REPORTS 8 ( 6 ) 31084 2016.08

Research paper (scientific journal), Joint Work

Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.

OKANO HIDEYUKI

Neuroscience Research  2016.08

Research paper (scientific journal), Joint Work

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Functional Recovery from Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury.

OKANO HIDEYUKI

SCIENTIFIC REPORTS 3 ( 6 ) 30898 2016.08

Research paper (scientific journal), Joint Work

Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea.

OKANO HIDEYUKI

Neuroreport 3 ( 27(11) ) 833 - 836 2016.08

Research paper (scientific journal)

SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.

OKANO HIDEYUKI

nature genetics 48(7)   792 - 797 2016.07

Research paper (scientific journal)

Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.

OKANO HIDEYUKI

BioMedCentral 27 ( 16 ) 548 2016.07

Research paper (scientific journal), Joint Work

In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.

OKANO HIDEYUKI

Molecular Brain 19 ( 9(1) ) 70 2016.07

Research paper (scientific journal), Joint Work

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.

OKANO HIDEYUKI

Cell Stem Cell 7 ( 19(1) ) 127 - 138 2016.07

Research paper (scientific journal), Joint Work

Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field.

OKANO HIDEYUKI

Neuroscience Research 107   20 - 29 2016.06

Research paper (scientific journal)