Papers - Okano, Hideyuki

Roles of ES Cell-Derived Gliogenic Neural Stem/Progenitor Cells in Functional Recovery after Spinal Cord Injury

Kumagai, Gentaro, Okada, Yohei, Yamane, Junichi, Nagoshi, Narihito, Kitamura, Kazuya, Mukaino, Masahiko, Tsuji, Osahiko, Fujiyoshi, Kanehiro, Katoh, Hiroyuki, Okada, Seiji, Shibata, Shinsuke, Matsuzaki, Yumi, Toh, Satoshi, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki

PLOS ONE 4 ( 11 ) 1109 - 1119 2009.11

Research paper (scientific journal),  ISSN  1932-6203

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Strategies toward CNS-regeneration using induced pluripotent stem cells.

Okano Hideyuki

Genome informatics. International Conference on Genome Informatics 23 ( 1 ) 217 - 220 2009.10

ISSN  0919-9454

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<p>Induced pluripotent stem (iPS) cells are pluripotent stem cells directly reprogrammed from cultured mouse fibroblast by introducing Oct3/4, Sox2, c-Myc, and Klf4. Cells obtained using this technology, which allows the ethical issues and immunological rejection associated with embryonic stem (ES) cells to be avoided, might be a clinically useful source for cell replacement therapics. Here we demonstrate that murine iPS cells formed neurospheres that produced electrophysiologically functional neurons, astrocytes, and oligodendrocytes. Secondary neurospheres (SNSs) generated from various mouse iPS cell showed their neural differentiation capacity and teratoma formation after transplantation into the brain of immunodeficient NOD/SCID mice. We found that origin (source of somatic cells) of the iPS cells are the crucial determinant for the potential tumorigenicity of iPS-derived neural stem/progenitor cclls and that their tumorigenicity results from the persistent presence of undifferentiated cells within the SNSs. Furthermore, transplantation of non-tumorigenic Nanog-iPS-derived SNSs into mouse spinal cord injury (SCI) model promoted locomotor function recovery. Surprisingly, SNSs derived from c-Myc minus iPS cells generated without drug selection showed robust tumorigenesis, in spite of their potential to contribute adult chimeric mice without tumor formation.</p>

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Morikawa, Satoru, Mabuchi, Yo, Kubota, Yoshiaki, Nagai, Yasuo, Niibe, Kunimichi, Hiratsu, Emi, Suzuki, Sadafumi, Miyauchi-Hara, Chikako, Nagoshi, Narihito, Sunabori, Takehiko, Shimmura, Shigeto, Miyawaki, Atsushi, Nakagawa, Taneaki, Suda, Toshio, Okano, Hideyuki, Matsuzaki, Yumi

JOURNAL OF EXPERIMENTAL MEDICINE 206 ( 11 ) 2483 - 2496 2009.10

Research paper (scientific journal),  ISSN  0022-1007

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Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

Tamase, Akira, Muraguchi, Teruyuki, Naka, Kazuhito, Tanaka, Shingo, Kinoshita, Masashi, Hoshii, Takayuki, Ohmura, Masako, Shugo, Haruhiko, Ooshio, Takako, Nakada, Mitsutoshi, Sawamoto, Kazunobu, Onodera, Masafumi, Matsumoto, Kunio, Oshima, Masanobu, Asano, Masahide, Saya, Hideyuki, Okano, Hideyuki, Suda, Toshio, Hamada, Jun-ichiro, Hirao, Atsushi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 40 ) 17163 - 17168 2009.10

Research paper (scientific journal),  ISSN  0027-8424

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ENVIRONMENTAL CUE-DEPENDENT DOPAMINERGIC NEURONAL DIFFERENTIATION AND FUNCTIONAL EFFECT OF GRAFTED NEUROEPITHELIAL STEM CELLS IN PARKINSONIAN BRAIN

Mine, Yutaka, Hayashi, Takuro, Yamada, Motoyuki, Okano, Hideyuki, Kawase, Takeshi

NEUROSURGERY 65 ( 4 ) 741 - 753 2009.10

Research paper (scientific journal),  ISSN  0148-396X

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Cell surface N-glycans mediated isolation of mouse neural stem cells

Hamanoue, Makoto, Matsuzaki, Yumi, Sato, Ken-ichiro, Okano, Hirotaka James, Shibata, Shinsuke, Sato, Isamu, Suzuki, Sadafumi, Ogawara, Miyuki, Takamatsu, Ken, Okano, Hideyuki

JOURNAL OF NEUROCHEMISTRY 110 ( 5 ) 1575 - 1584 2009.09

Research paper (scientific journal),  ISSN  0022-3042

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ABCB1 Is Predominantly Expressed in Human Fetal Neural Stem/progenitor Cells at an Early Development Stage

Yamamoto, Atsuyo, Shofuda, Tomoko, Islam, Mohammed Omedul, Nakamura, Yasuhiro, Yamasaki, Mami, Okano, Hideyuki, Kanemura, Yonehiro

JOURNAL OF NEUROSCIENCE RESEARCH 87 ( 12 ) 2615 - 2623 2009.09

Research paper (scientific journal),  ISSN  0360-4012

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Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1

Oishi, Koji, Watatani, Kenji, Itoh, Yasuhiro, Okano, Hideyuki, Guillemot, Francois, Nakajima, Kazunori, Gotoh, Yukiko

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 31 ) 13064 - 13069 2009.08

Research paper (scientific journal),  ISSN  0027-8424

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RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans (vol 179, pg 1149, 2007)

Oishi, Kumiko, Okano, Hideyuki, Sawa, Hitoshi

JOURNAL OF CELL BIOLOGY 186 ( 4 ) 629 - 629 2009.08

Research paper (scientific journal),  ISSN  0021-9525

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Neural Crest-Derived Stem Cells Display a Wide Variety of Characteristics

Nagoshi, Narihito, Shibata, Shinsuke, Nakamura, Masaya, Matsuzaki, Yumi, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF CELLULAR BIOCHEMISTRY 107 ( 6 ) 1046 - 1052 2009.08

Research paper (scientific journal),  ISSN  0730-2312

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Variation in the safety of induced pluripotent stem cell lines

Miura, Kyoko, Okada, Yohei, Aoi, Takashi, Okada, Aki, Takahashi, Kazutoshi, Okita, Keisuke, Nakagawa, Masato, Koyanagi, Michiyo, Tanabe, Koji, Ohnuki, Mari, Ogawa, Daisuke, Ikeda, Eiji, Okano, Hideyuki, Yamanaka, Shinya

NATURE BIOTECHNOLOGY 27 ( 8 ) 743 - 745 2009.08

Research paper (scientific journal),  ISSN  1087-0156

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Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development

Saiga, Toru, Fukuda, Takaichi, Matsumoto, Masaki, Tada, Hirobumi, Okano, Hirotaka James, Okano, Hideyuki, Nakayama, Keiichi I.

MOLECULAR AND CELLULAR BIOLOGY 29 ( 13 ) 3529 - 3543 2009.07

Research paper (scientific journal),  ISSN  0270-7306

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3 '-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein

Horisawa, Kenichi, Imai, Takao, Okano, Hideyuki, Yanagawa, Hiroshi

FEBS LETTERS 583 ( 14 ) 2429 - 2434 2009.07

Research paper (scientific journal),  ISSN  0014-5793

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Possibility of iPS cells (discussion)

Okano Hideyuki, Yamanaka Shinya, Tsuji Shoji

Brain and nerve = Shinkei kenkyū no shinpo 61 ( 6 ) 711 - 718 2009.06

ISSN  1881-6096

Drosophila big brain does not act as a water channel, but mediates cell adhesion

Tatsumi, Kimiko, Tsuji, Shoji, Miwa, Hideki, Morisaku, Toshinori, Nuriya, Mutsuo, Orihara, Minako, Kaneko, Kazunari, Okano, Hideyuki, Yasui, Masato

FEBS LETTERS 583 ( 12 ) 2077 - 2082 2009.06

Research paper (scientific journal),  ISSN  0014-5793

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The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

Kiso, Makoto, Tanaka, Shigekazu, Saba, Rie, Matsuda, Satoru, Shimizu, Atsushi, Ohyama, Manabu, Okano, Hirotaka James, Shiroishi, Toshihiko, Okano, Hideyuki, Saga, Yumiko

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 ( 23 ) 9292 - 9297 2009.06

Research paper (scientific journal),  ISSN  0027-8424

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Generation of transgenic non-human primates with germline transmission

Sasaki, Erika, Suemizu, Hiroshi, Shimada, Akiko, Hanazawa, Kisaburo, Oiwa, Ryo, Kamioka, Michiko, Tomioka, Ikuo, Sotomaru, Yusuke, Hirakawa, Reiko, Eto, Tomoo, Shiozawa, Seiji, Maeda, Takuji, Ito, Mamoru, Ito, Ryoji, Kito, Chika, Yagihashi, Chie, Kawai, Kenji, Miyoshi, Hiroyuki, Tanioka, Yoshikuni, Tamaoki, Norikazu, Habu, Sonoko, Okano, Hideyuki, Nomura, Tatsuji

NATURE 459 ( 7246 ) 523 - U50 2009.05

Research paper (scientific journal),  ISSN  0028-0836

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Tumor initiating potential of side population cells in human gastric cancer

Fukuda, Kazumasa, Saikawa, Yoshiro, Ohashi, Masaki, Kumagai, Koshi, Kitajima, Masaki, Okano, Hideyuki, Matsuzaki, Yumi, Kitagawa, Yuko

INTERNATIONAL JOURNAL OF ONCOLOGY 34 ( 5 ) 1201 - 1207 2009.05

Research paper (scientific journal),  ISSN  1019-6439

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M-Numb Expression Induced Gastric Mucosal Regeneration After Injury By Stimulating the Expression of Morphogenic Genes

Takahashi, Tetsufumi, Suzuki, Hidekazu, Saito, Yoshimasa, Nagata, Hiroshi, Okano, Hideyuki, Hibi, Toshifumi

GASTROENTEROLOGY 136 ( 5 ) A23 - A23 2009.05

Research paper (scientific journal),  ISSN  0016-5085

Effect of a Gradient Static Magnetic Field on an Unstirred Belousov-Zhabotinsky Reaction by Changing the Thickness of the Medium

Okano, Hideyuki, Kitahata, Hiroyuki, Akai, Daisuke

JOURNAL OF PHYSICAL CHEMISTRY A 113 ( 13 ) 3061 - 3067 2009.04

Research paper (scientific journal),  ISSN  1089-5639

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