Papers - Okano, Hideyuki

Possible implication of mu-opioid receptors in the neural differentiation from embryonic stem cells

Kuzumaki, Naoko, Narita, Minoru, Yajima, Marie, Narita, Michiko, Imai, Satoshi, Furuta, Sadayoshi, Okada, Yohei, Okano, James Hirotaka, Okano, Hideyuki, Suzuki, Tsutomu

NEUROSCIENCE RESEARCH 65   S137 - S137 2009

Research paper (scientific journal),  ISSN  0168-0102

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SLIT-ROBO SIGNALING REGULATES THE MIGRATION OF NEW NEURONS UNDER PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS

Kaneko, Naoko, Marin, Oscar, Hirota, Yuki, Rubenstein, John, Murakami, Fujio, Alvarez-Buylla, Arturo, Okano, Hideyuki, Tessier-Lavigne, Marc, Sawamoto, Kazunobu

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   442 - 442 2009

Research paper (scientific journal),  ISSN  1880-6546

THE CHARACTERIZATION OF THE CEREBELLAR PURKINJE CELLS INDUCED FROM THE MICE EMBRYONIC STEM CELLS AND TRANSPLANTATION INTO THE ADULT PCD MICE

Tao, Osamu, Xu, Haiyan, Shimazaki, Takuya, Kohda, Kazuhisa, Yuzaki, Michisuke, Mizusawa, Hidehiro, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   343 - 343 2009

Research paper (scientific journal),  ISSN  1880-6546

Sensory network formation of RNA binding protein Musashi2

Shibata, Shinsuke, Sakakibara, Shin-ichi, Furue, Hidemasa, Yoshimura, Megumu, Kuwako, Ken-ichiro, Okano, James Hirotaka, Okano, Hideyuki

NEUROSCIENCE RESEARCH 65   S96 - S96 2009

Research paper (scientific journal),  ISSN  0168-0102

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Role of Diversin as a possible switch of distinct Wnt pathways regulating multiple steps of adult neurogenesis

Ikeda, Makiko, Hirota, Yuki, Sakaguchi, Masanori, Yamada, Osamu, Kida, Yasuyuki, Ogura, Tashihiko, Otsuka, Takanobu, Okano, Hideyuki, Sawamoto, Kazunobu

NEUROSCIENCE RESEARCH 65   S54 - S54 2009

Research paper (scientific journal),  ISSN  0168-0102

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ROLES OF RNA BINDING PROTEIN Hu IN DEVELOPING AND MATURE NEURONS

Okano, Hirotaka James, Kakumoto, Kyoko, Yano, Masato, Darnell, Robert B., Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   343 - 343 2009

Research paper (scientific journal),  ISSN  1880-6546

ROLE OF WNT/BETA-CATENIN SIGNALING IN NEUROGENESIS IN THE ADULT MOUSE SUBVENTRICULAR ZONE

Sawamoto, Kazunobu, Adachi, Kazuhide, Ikeda, Makiko, Hirota, Yuki, Sakaguchi, Masanori, Yamada, Osamu, Kida, Yasuyuki, Ogura, Toshihiko, Mirzadeh, Zaman, Nikolcheva, Tania, Gotoh, Yukiko, Peltz, Gary, Gong, Leyi, Alvarez-Buylla, Arturo, Ohtsuka, Takanobu, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   442 - 442 2009

Research paper (scientific journal),  ISSN  1880-6546

DIFFUSION TENSOR PERIPHERAL NERVE TRACTOGRAPHY

Takagi, Takehiko, Nakamura, Masaya, Yamada, Masayuki, Hikishima, Keigo, Momoshima, Suketaka, Fujiyoshi, Kanehiro, Shibata, Shinsuke, Okano, Hirotaka James, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   293 - 293 2009

Research paper (scientific journal),  ISSN  1880-6546

Promotion of the neural differentiation from embryonic stem cells activated by dopamine D-3 receptors

Yajima, Marie, Kuzumaki, Naoko, Narita, Minoru, Narita, Michiko, Imai, Satoshi, Okada, Yohei, Okano, James Hirotaka, Okano, Hideyuki, Suzuki, Tsutomu

NEUROSCIENCE RESEARCH 65   S137 - S137 2009

Research paper (scientific journal),  ISSN  0168-0102

• Access to Document (DOI)

A role of neuronal RNA binding protein Hu and NF45/NF90 in the nervous system

Igarashi, Mana, Yano, Masato, Okano, James Hirotaka, Okano, Hideyuki

NEUROSCIENCE RESEARCH 65   S90 - S90 2009

Research paper (scientific journal),  ISSN  0168-0102

• Access to Document (DOI)

Genetic analysis of the organization and function of the blood brain barrier in Drosophila

Kanda, Hiroshi, Shimamura, Rieko, Okano, Hideyuki

NEUROSCIENCE RESEARCH 65   S150 - S150 2009

Research paper (scientific journal),  ISSN  0168-0102

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Strategies toward regenerating the damaged CNS using ES/iPS cells

Okano, Hideyuki

NEUROSCIENCE RESEARCH 65   S1 - S1 2009

Research paper (scientific journal),  ISSN  0168-0102

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Neuroepithelial stem cells are converted into neural progenitors during an elongated interphase in drosophila larval optic lobe

Orihara-Ono, Minako, Nakao, Keiko, Okano, Hideyuki

JOURNAL OF NEUROGENETICS 23   S19 - S19 2009

Research paper (scientific journal),  ISSN  0167-7063

Analysis of cell surface glycoproteins on neural stem cells

Hamanoue, Makoto, Okano, Hirotaka, Okano, Hideyuki, Takamatsu, Ken

NEUROSCIENCE RESEARCH 65   S90 - S91 2009

Research paper (scientific journal),  ISSN  0168-0102

• Access to Document (DOI)

AXONAL DEGENERATION IN HuC-DEFICIENT CEREBELLUM

Kakumoto, Kyoko, Okano, Hirotaka James, Darnell, Robert B., Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   337 - 337 2009

Research paper (scientific journal),  ISSN  1880-6546

ROLE AND MECHANISMS OF REACTIVE ASTROCYTE S MIGRATION AFTER SPINAL CORD INJURY

Renault-Mihara, Francois, Mukaino, Masahiko, Nakamura, Masaya, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   341 - 341 2009

Research paper (scientific journal),  ISSN  1880-6546

Analysis of spinal cord injury using diffusion MRI

Nakamura, Masaya, Fujiyoshi, Kanehiro, Hikishima, Keigo, Toyama, Yoshiaki, Okano, Hideyuki

NEUROSCIENCE RESEARCH 65   S35 - S35 2009

Research paper (scientific journal),  ISSN  0168-0102

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COMPARATIVE STUDY OF DIFFERENT ADMINISTRATIONS OF THE NEURAL STEM CELLS FOR SPINAL CORD INJURY IN MICE

Takahashi, Yuichiro, Nakamura, Masaya, Tuji, Osahiko, Kumagai, Gentaro, Hara, Chikako, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   442 - 442 2009

Research paper (scientific journal),  ISSN  1880-6546

A ROLE FOR RNA-BINDING PROTEIN MUSASHI 1 IN REGULATING THE AXONAL MIDLINE CROSSING

Kuwako, Ken-ichiro, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59   342 - 342 2009

Research paper (scientific journal),  ISSN  1880-6546

Epigenetic mechanisms regulating neural cell fate determination

Nakashima Kinichi, Kohyama Jun, Namihira Masakazu, Gage Fred H., Okano Hideyuki, Sawamoto Kazunobu

No To Hattatsu 41 ( 6 ) 411 - 414 2009

ISSN  0029-0831

　View Summary

<p>Neural stem/progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes, and oligodendrocytes. It has become apparent that intracellular epigenetic modification including DNA methylation, in concert with extracellular cues such as cytokine signaling, is deeply involved in specifiying the fate of NSCs/NPCs by defining cell-type specific gene expression. However, it is still unclear how differentiated neural cells retain their specific attributes by repressing cellular properties characteristic of other lineages. In previous work, we have shown that methyl-CpG binding protein transcriptional repressors (MBDs), which were expressed predominantly in neurons in the central nervous system, inhibited astrocyte-specific gene expression by binding to highly methylated regions of their target genes. Here we report that oligodendrocytes, which do not express MBDs, can transdifferentiate into astrocytes both in vitro (cytokine stimulation) and in vivo (ischemic injury) through the activation of the JAK/STAT signaling pathway. These findings suggest that differentiation plasticity in neural cells is regulated by cell-intrinsic epigenetic mechanisms in collaboration with ambient cell-extrinsic cues.</p>