Papers - Okano, Hideyuki

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

Iwanami, Akio, Gini, Beatrice, Zanca, Ciro, Matsutani, Tomoo, Assuncao, Alvaro, Nael, Ali, Dang, Julie, Yang, Huijun, Zhu, Shaojun, Kohyama, Jun, Kitabayashi, Issay, Cavenee, Webster K., Cloughesy, Timothy F., Furnari, Frank B., Nakamura, Masaya, Toyama, Yoshiaki, Okano, Hideyuki, Mischel, Paul S.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 ( 11 ) 4339 - 4344 2013.03

Research paper (scientific journal),  ISSN  0027-8424

• Access to Document (DOI)

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

Iwanami, Akio, Gini, Beatrice, Zanca, Ciro, Matsutani, Tomoo, Assuncao, Alvaro, Nael, Ali, Dang, Julie, Yang, Huijun, Zhu, Shaojun, Kohyama, Jun, Kitabayashi, Issay, Cavenee, Webster K., Cloughesy, Timothy F., Furnari, Frank B., Nakamura, Masaya, Toyama, Yoshiaki, Okano, Hideyuki, Mischel, Paul S.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110 ( 11 ) 4339 - 4344 2013.03

Research paper (scientific journal),  ISSN  0027-8424

• Access to Document (DOI)

Aberrant Gene Expression and Sexually Incompatible Genomic Imprinting in Oocytes Derived from XY Mouse Embryonic Stem Cells In Vitro

Nitta, Mai, Imamura, Masanori, Inoue, Yu, Kunitomo, Yasuo, Lin, Zachary Yu-Ching, Ogawa, Takuya, Yogo, Keiichiro, Ishida-Kitagawa, Norihiro, Fukunaga, Noritaka, Okano, Hideyuki, Sato, Eimei, Takeya, Tatsuo, Miyoshi, Jun

PLOS ONE 8 ( 3 ) 116 - 125 2013.03

Research paper (scientific journal),  ISSN  1932-6203

• Access to Document (DOI)

Functional Corneal Endothelium Derived from Corneal Stroma Stem Cells of Neural Crest Origin by Retinoic Acid and Wnt/beta-Catenin Signaling

Hatou, Shin, Yoshida, Satoru, Higa, Kazunari, Miyashita, Hideyuki, Inagaki, Emi, Okano, Hideyuki, Tsubota, Kazuo, Shimmura, Shigeto

STEM CELLS AND DEVELOPMENT 22 ( 5 ) 682 - 696 2013.03

Research paper (scientific journal),  ISSN  1547-3287

• Access to Document (DOI)

Enhanced Aggregation of Androgen Receptor in Induced Pluripotent Stem Cell-derived Neurons from Spinal and Bulbar Muscular Atrophy

Nihei, Yoshihiro, Ito, Daisuke, Okada, Yohei, Akamatsu, Wado, Yagi, Takuya, Yoshizaki, Takahito, Okano, Hideyuki, Suzuki, Norihiro

JOURNAL OF BIOLOGICAL CHEMISTRY 288 ( 12 ) 8043 - 8052 2013.03

Research paper (scientific journal),  ISSN  0021-9258

• Access to Document (DOI)

Assessment of homozygosity levels in the mito-gynogenetic torafugu (Takifugu rubripes) by genome-wide SNP analyses

Zhang, Hong, Hirose, Yusuke, Yoshino, Rintaro, Kinoshita, Shigeharu, Saito, Kazuyoshi, Tan, Engkong, Suzuki, Yutaka, Shimizu, Atsushi, Okano, Hideyuki, Kudoh, Jun, Watabe, Shugo, Asakawa, Shuichi

AQUACULTURE 380   114 - 119 2013.03

Research paper (scientific journal),  ISSN  0044-8486

• Access to Document (DOI)

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain

Imai, Satoshi, Ikegami, Daigo, Yamashita, Akira, Shimizu, Toshikazu, Narita, Michiko, Niikura, Keiichi, Furuya, Masaharu, Kobayashi, Yasuhisa, Miyashita, Kazuhiko, Okutsu, Daiki, Kato, Akira, Nakamura, Atsushi, Araki, Akiko, Omi, Kazuo, Nakamura, Masaya, Okano, Hirotaka James, Okano, Hideyuki, Ando, Takayuki, Takeshima, Hideyuki, Ushijima, Toshikazu, Kuzumaki, Naoko, Suzuki, Tsutomu, Narita, Minoru

BRAIN 136   828 - 843 2013.03

Research paper (scientific journal),  ISSN  0006-8950

• Access to Document (DOI)

[Reconstruction for spinal cord injury].

Hori Keiko, Nakamura Masaya, Okano Hideyuki

Nihon Jibiinkoka Gakkai kaiho 116 ( 2 ) 53 - 59 2013.02

ISSN  0030-6622

• Access to Document (DOI)

Semaphorin 3A regulates bone homeostasis through sensory nerve system

Fukuda, Toru, Xu, Ren, Ochi, Hiroki, Sunamura, Satoko, Sato, Tsuyoshi, Shibata, Shinsuke, Ma, Chenshan, Xu, Cheng, Kimura, Ayako, Asou, Yoshinori, Enomoto, Mitsuhiro, Okano, Hideyuki, Okawa, Atsushi, Ito, Hiroshi, Takeda, Shu

JOURNAL OF BONE AND MINERAL RESEARCH 28   S154 - S154 2013.02

Research paper (scientific journal),  ISSN  0884-0431

Steps Toward Safe Cell Therapy Using Induced Pluripotent Stem Cells

Okano, Hideyuki, Nakamura, Masaya, Yoshida, Kenji, Okada, Yohei, Tsuji, Osahiko, Nori, Satoshi, Ikeda, Eiji, Yamanaka, Shinya, Miura, Kyoko

CIRCULATION RESEARCH 112 ( 3 ) 523 - 533 2013.02

Research paper (scientific journal),  ISSN  0009-7330

• Access to Document (DOI)

Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology

Hikishima K., Sawada K., Murayama A. Y., Komaki Y., Kawai K., Sato N., Inoue T., Itoh T., Momoshima S., Iriki A., Okano H. J., Sasaki E., Okano H.

Neuroscience 230   102 - 113 2013.01

ISSN  0306-4522

　View Summary

<p>The developmental anatomy of the brain is largely directed by neural-based cues. Despite this knowledge, the developmental trajectory of the primate brain has not yet been fully characterized. To realize this goal, the advance in noninvasive imaging methods and new brain atlases are essential. The common marmoset (Callithrix jacchus), a small New World primate, is widely used in neuroscience research. The recent introduction of transgenic techniques has enabled the marmoset to be used as a genetically modifiable primate model for brain development. Here, a magnetic resonance histology technique involving the use of ultra-high-resolution ex vivo magnetic resonance imaging (MRI) was performed to identify the developmental anatomy of the marmoset brain at different time points from gestational week 8 through to birth. The data allowed the generation of a multidimensional atlas of brain structures at different developmental stages. Furthermore, in utero MRI techniques were developed to noninvasively monitor brain development during the embryonic and fetal stages. The multidimensional atlas and the MRI tools developed herein are anticipated to further our understanding of the developing primate brain. © 2012 IBRO.</p>

• Access to Document (DOI)

Cell-intrinsic reprogramming capability

Imamura Masanori, Lin Zachary Yu Ching, Okano Hideyuki

Reproductive Medicine and Biology 12 ( 1 ) 1 - 14 2013.01

ISSN  1445-5781

　View Summary

<p>In multicellular organisms, germ cells are an extremely specialized cell type with the vital function of transmitting genetic information across generations. In this respect, they are responsible for the perpetuity of species, and are separated from somatic lineages at each generation. Interestingly, in the past two decades research has shown that germ cells have the potential to proceed along two distinct pathways: gametogenesis or pluripotency. Unequivocally, the primary role of germ cells is to produce gametes, the sperm or oocyte, to produce offspring. However, under specific conditions germ cells can become pluripotent, as shown by teratoma formation in vivo or cell culture-induced reprogramming in vitro. This phenomenon seems to be a general propensity of germ cells, irrespective of developmental phase. Recent attempts at cellular reprogramming have resulted in the generation of induced pluripotent stem cells (iPSCs). In iPSCs, the intracellular molecular networks instructing pluripotency have been activated and override the exclusively somatic cell programs that existed. Because the generation of iPSCs is highly artificial and depends on gene transduction, whether the resulting machinery reflects any physiological cell-intrinsic programs is open to question. In contrast, germ cells can spontaneously shift their fate to pluripotency during in-vitro culture. Here, we review the two fates of germ cells, i.e., differentiation and reprogramming. Understanding the molecular mechanisms regulating differentiation versus reprogramming would provide invaluable insight into understanding the mechanisms of cellular reprogramming that generate iPSCs. © 2012 Japan Society for Reproductive Medicine.</p>

• Access to Document (DOI)

Musashi-1 Post-Transcriptionally Enhances Phosphotyrosine-Binding Domain-Containing m-Numb Protein Expression in Regenerating Gastric Mucosa

Takahashi, Tetsufumi, Suzuki, Hidekazu, Imai, Takao, Shibata, Shinsuke, Tabuchi, Yoshiaki, Tsuchimoto, Kanji, Okano, Hideyuki, Hibi, Toshifumi

PLOS ONE 8 ( 1 ) 1669 - 1681 2013.01

Research paper (scientific journal),  ISSN  1932-6203

• Access to Document (DOI)

Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury

Nishimura, Soraya, Yasuda, Akimasa, Iwai, Hiroki, Takano, Morito, Kobayashi, Yoshiomi, Nori, Satoshi, Tsuji, Osahiko, Fujiyoshi, Kanehiro, Ebise, Hayao, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

MOLECULAR BRAIN 6   1451 - 1464 2013.01

Research paper (scientific journal),  ISSN  1756-6606

• Access to Document (DOI)

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

Hirata, Akihiro, Utikal, Jochen, Yamashita, Satoshi, Aoki, Hitomi, Watanabe, Akira, Yamamoto, Takuya, Okano, Hideyuki, Bardeesy, Nabeel, Kunisada, Takahiro, Ushijima, Toshikazu, Hara, Akira, Jaenisch, Rudolf, Hochedlinger, Konrad, Yamada, Yasuhiro

DEVELOPMENT 140 ( 1 ) 66 - 75 2013.01

Research paper (scientific journal),  ISSN  0950-1991

• Access to Document (DOI)

In Vivo Tracing of Neural Tracts in Tiptoe Walking Yoshimura Mice by Diffusion Tensor Tractography

Takano, Morito, Komaki, Yuji, Hikishima, Keigo, Konomi, Tsunehiko, Fujiyoshi, Kanehiro, Tsuji, Osahiko, Toyama, Yoshiaki, Okano, Hideyuki, Nakamura, Masaya

SPINE 38 ( 2 ) E66 - E72 2013.01

Research paper (scientific journal),  ISSN  0362-2436

• Access to Document (DOI)

Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells

Nakamura, Masaya, Okano, Hideyuki

CELL RESEARCH 23 ( 1 ) 70 - 80 2013.01

Research paper (scientific journal),  ISSN  1001-0602

• Access to Document (DOI)

Human induced pluripotent stem (iPS) cells-derived neural stem cell bundle covered with growth factor-encapsulated amphiphilic chitosan

Kato-Negishi Midori, Onoe Hiroaki, Iwanaga Shintaroh, Kobayashi Yoshiomi, Nakamura Masaya, Okano Hideyuki, Takeuchi Shoji

  1054 - 1056 2013

　View Summary

<p>This paper describes human induced pluripotent stem (iPS) cell-derived neural stem cell (hiPSC-NSC) bundles covered with growth factor-encapsulated amphiphilic chitosan. The hiPSC-NSC bundle is formed by 4-12 hiPSC-NSC microfibers that are made by core-shell hydrogel microfibers encapsulating hiPSC-NSCs. The hiPSC-NSC microfibers can be cultured for over two weeks and induced to differentiate into neurons predominantly. We modified the coating material to make bundle structures that have growth factor enrichment capability (Figure 1). The coating material, amphiphilic chitosan, can release growth factors slowly for a long time, allowing hiPSC-NSCs to survive, grow and differentiate into neural lineages in the bundle structure. We believe that our hiPSC-NSC bundle would be an extremely effective tool for neural transplantation in neurodegenerative diseases such as stroke, spinal cord injury and peripheral nerve injury, because hiPSC-NSCs in the bundle structure have long-term survival ability in vivo.</p>

Identification and analysis of target genes of the Rett syndrome causative gene, Mecp2, in the cerebral cortex

Kishi, Noriyuki, Macklis, Jeffrey D., Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 63   S25 - S25 2013

Research paper (scientific journal),  ISSN  1880-6546

Multiple profiling of changes in miRNA expression under the neuropathic pain

Yamashita, Akira, Hamada, Asami, Suhara, Yuki, Saisu, Hironori, Shimura, Eri, Narita, Michiko, Kuzumaki, Naoko, Ochiya, Takahiro, Okano, Hideyuki, Narita, Minoru

JOURNAL OF PHARMACOLOGICAL SCIENCES 121   121P - 121P 2013

Research paper (scientific journal),  ISSN  1347-8613