Papers - Okano, Hideyuki

Lizards respond to an extremely low-frequency electromagnetic field

Nishimura, Tsutomu, Okano, Hideyuki, Tada, Harue, Nishimura, Etsuko, Sugimoto, Kenji, Mohri, Kaneo, Fukushima, Masanori

JOURNAL OF EXPERIMENTAL BIOLOGY 213 ( 12 ) 1985 - 1990 2010.06

Research paper (scientific journal),  ISSN  0022-0949

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Synaptic Input of ON-Bipolar Cells onto the Dopaminergic Neurons of the Mouse Retina

Contini, Massimo, Lin, Bin, Kobayashi, Kazuto, Okano, Hideyuki, Masland, Richard H., Raviola, Elio

JOURNAL OF COMPARATIVE NEUROLOGY 518 ( 11 ) 2035 - 2050 2010.06

Research paper (scientific journal),  ISSN  0021-9967

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The Musashi family RNA-binding proteins in stem cells

Horisawa Kenichi, Imai Takao, Okano Hideyuki, Yanagawa Hiroshi

Biomolecular Concepts 1 ( 1 ) 59 - 66 2010.05

ISSN  1868-5021

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<p>The Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date. Msi1 is considered to play roles in maintaining the stem cell status (stemness) of neural stem/progenitor cells in adults and in the development of central nervous system through translational regulation of its target mRNAs, which encode regulators of signal transduction and the cell cycle. Recently, strong expression of Msi1 in various somatic stem/progenitor cells of adult tissues, such as eye, gut, stomach, breast, and hair follicle, has been reported. The protein is also expressed in various cancer cells, and ectopically emerging cells have been found in neural tissues of patients with diseases involving neural disorder, including epilepsy. Many novel target mRNAs and regulatory pathways of Msi1 have been reported in recent years. Here, we present a review of the functions and action mechanisms of Msi1 protein and discuss possible directions for further study.</p>

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The LTB4-BLT1 Axis Mediates Neutrophil Infiltration and Secondary Injury in Experimental Spinal Cord Injury

Saiwai, Hirokazu, Ohkawa, Yasuyuki, Yamada, Hisakata, Kumamaru, Hiromi, Harada, Akihito, Okano, Hideyuki, Yokomizo, Takehiko, Iwamoto, Yukihide, Okada, Seiji

AMERICAN JOURNAL OF PATHOLOGY 176 ( 5 ) 2352 - 2366 2010.05

Research paper (scientific journal),  ISSN  0002-9440

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Transplantation of Galectin-1-Expressing Human Neural Stem Cells Into the Injured Spinal Cord of Adult Common Marmosets

Yamane, Junichi, Nakamura, Masaya, Iwanami, Akio, Sakaguchi, Masanori, Katoh, Hiroyuki, Yamada, Masayuki, Momoshima, Suketaka, Miyao, Sachiyo, Ishii, Ken, Tamaoki, Norikazu, Nomura, Tatsuji, Okano, Hirotaka James, Kanemura, Yonehiro, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF NEUROSCIENCE RESEARCH 88 ( 7 ) 1394 - 1405 2010.05

Research paper (scientific journal),  ISSN  0360-4012

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Analysis of the Expression and Function of BRINP Family Genes During Neuronal Differentiation in Mouse Embryonic Stem Cell-Derived Neural Stem Cells

Terashima, Michiyo, Kobayashi, Miwako, Motomiya, Makoto, Inoue, Nobuo, Yoshida, Tetsu, Okano, Hideyuki, Iwasaki, Norimasa, Minami, Akio, Matsuoka, Ichiro

JOURNAL OF NEUROSCIENCE RESEARCH 88 ( 7 ) 1387 - 1393 2010.05

Research paper (scientific journal),  ISSN  0360-4012

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von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina

Kurihara, Toshihide, Kubota, Yoshiaki, Ozawa, Yoko, Takubo, Keiyo, Noda, Kousuke, Simon, M. Celeste, Johnson, Randall S., Suematsu, Makoto, Tsubota, Kazuo, Ishida, Susumu, Goda, Nobuhito, Suda, Toshio, Okano, Hideyuki

DEVELOPMENT 137 ( 9 ) 1563 - 1571 2010.05

Research paper (scientific journal),  ISSN  0950-1991

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BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Kohyama, Jun, Sanosaka, Tsukasa, Tokunaga, Akinori, Takatsuka, Eriko, Tsujimura, Keita, Okano, Hideyuki, Nakashima, Kinichi

JOURNAL OF CELL BIOLOGY 189 ( 1 ) 159 - U220 2010.04

Research paper (scientific journal),  ISSN  0021-9525

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Musashi1 as a marker of reactive astrocytes after transient focal brain ischemia

Oki, Koichi, Kaneko, Naoko, Kanki, Hiroaki, Imai, Takao, Suzuki, Norihiro, Sawamoto, Kazunobu, Okano, Hideyuki

NEUROSCIENCE RESEARCH 66 ( 4 ) 390 - 395 2010.04

Research paper (scientific journal),  ISSN  0168-0102

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Regional Spinal Cord Cooling Using a Countercurrent Closed-Lumen Epidural Catheter

Shimizu, Hideyuki, Mori, Atsuo, Yamada, Tatsuya, Ishikawa, Akiko, Okano, Hideyuki, Takeda, Junzo, Yozu, Ryohei

ANNALS OF THORACIC SURGERY 89 ( 4 ) 1312 - 1313 2010.04

Research paper (scientific journal),  ISSN  0003-4975

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Neural stem cells and strategies for the regeneration of the central nervous system

Okano, Hideyuki

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 86 ( 4 ) 438 - 450 2010.04

Research paper (scientific journal),  ISSN  0386-2208

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Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea

Wakabayashi, Kenichiro, Fujioka, Masato, Kanzaki, Sho, Okano, Hirotaka James, Shibata, Shinsuke, Yamashita, Daisuke, Masuda, Masatsugu, Mihara, Masahiko, Ohsugi, Yoshiyuki, Ogawa, Kaoru, Okano, Hideyuki

NEUROSCIENCE RESEARCH 66 ( 4 ) 345 - 352 2010.04

Research paper (scientific journal),  ISSN  0168-0102

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Stem Cell-Like Properties of the Endometrial Side Population: Implication in Endometrial Regeneration

Masuda, Hirotaka, Matsuzaki, Yumi, Hiratsu, Emi, Ono, Masanori, Nagashima, Takashi, Kajitani, Takashi, Arase, Toru, Oda, Hideyuki, Uchida, Hiroshi, Asada, Hironori, Ito, Mamoru, Yoshimura, Yasunori, Maruyama, Tetsuo, Okano, Hideyuki

PLOS ONE 5 ( 4 ) E161 - E161 2010.04

Research paper (scientific journal),  ISSN  1932-6203

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Subventricular Zone-Derived Neural Progenitor Cells Migrate Along a Blood Vessel Scaffold Toward the Post-stroke Striatum

Kojima, Takuro, Hirota, Yuki, Ema, Masatsugu, Takahashi, Satoru, Miyoshi, Ichiro, Okano, Hideyuki, Sawamoto, Kazunobu

STEM CELLS 28 ( 3 ) 545 - 554 2010.03

Research paper (scientific journal),  ISSN  1066-5099

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Stromal Cell-Secreted Factors Promote the Survival of Embryonic Stem Cell-Derived Early Neural Stem/Progenitor Cells Via the Activation of MAPK and PI3K-Akt Pathways

Ishii, Seiji, Okada, Yohei, Kadoya, Toshihiko, Matsuzaki, Yumi, Shimazaki, Takuya, Okano, Hideyuki

JOURNAL OF NEUROSCIENCE RESEARCH 88 ( 4 ) 722 - 734 2010.03

Research paper (scientific journal),  ISSN  0360-4012

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Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells

Shindo Atsushi, Nakamura Takehiro, Matsumoto Yoshihito, Kawai Nobuyuki, Okano Hideyuki, Nagao Seigo, Itano Toshifumi, Tamiya Takashi

Neurologia Medico-Chirurgica 50 ( 2 ) 98 - 105 2010.02

ISSN  0470-8105

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<p>Embryonic stem cells (ES cells) differentiate into multiple cell lineages including neural cells. The present study optimized the method to induce differentiation of gamma-aminobutyric acid-producing neurons (GABAergic neurons) from ES cell-derived neural stem/progenitor cells (NS/PCs), and transplanted these ES cell-derived GABAergic neurons producing neural progenitors into kindled epileptic mice, and analyzed the morphological and functional recovery from epilepsy. The response of kindling was evaluated by the modified Racine scale. Following stage 5 kindling, the mice were divided into two groups. Group 1 received NS/PCs derived from the ES cells ubiquitously expressing green fluorescent protein transplanted into the dorsal hippocampal area. Group 2 received microinjections of only the medium. After transplantation, the recovery of seizures was evaluated by the modified Racine scale again. All mice were perfused and fixed for immunohistochemical analysis after finishing the kindling experiment. In Group 1, one mouse was classified as stage 0, five as stage 3, and one as stage 4 recovering from stage 5 at 6 weeks after transplantation. In Group 2, all mice remained in stage 5. The transplanted cells were examined immunohistochemically using neuronal and GABAergic markers. In the transplanted mice, substantial hippocampal GABAergic re-innervation and seizure-suppressing effects were observed. NS/PCs derived from ES cells have high potential for use in transplantation therapy for clinically intractable epilepsies.</p>

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Efficient Generation of Mature Cerebellar Purkinje Cells From Mouse Embryonic Stem Cells

Tao, Osamu, Shimazaki, Takuya, Okada, Yohei, Naka, Hayato, Kohda, Kazuhisa, Yuzaki, Michisuke, Mizusawa, Hidehiro, Okano, Hideyuki

JOURNAL OF NEUROSCIENCE RESEARCH 88 ( 2 ) 234 - 247 2010.02

Research paper (scientific journal),  ISSN  0360-4012

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Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

Kanazawa, Hideaki, Ieda, Masaki, Kimura, Kensuke, Arai, Takahide, Kawaguchi-Manabe, Haruko, Matsuhashi, Tomohiro, Endo, Jin, Sano, Motoaki, Kawakami, Takashi, Kimura, Tokuhiro, Monkawa, Toshiaki, Hayashi, Matsuhiko, Iwanami, Akio, Okano, Hideyuki, Okada, Yasunori, Ishibashi-Ueda, Hatsue, Ogawa, Satoshi, Fukuda, Keiichi

JOURNAL OF CLINICAL INVESTIGATION 120 ( 2 ) 408 - 421 2010.02

Research paper (scientific journal),  ISSN  0021-9738

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Seizure Suppression in Amygdala-Kindled Mice by Transplantation of Neural Stem/Progenitor Cells Derived From Mouse Embryonic Stem Cells

Shindo, Atsushi, Nakamura, Takehiro, Matsumoto, Yoshihito, Kawai, Nobuyuki, Okano, Hideyuki, Nagao, Seigo, Itano, Toshifumi, Tamiya, Takashi

NEUROLOGIA MEDICO-CHIRURGICA 50 ( 2 ) 98 - 105 2010.02

Research paper (scientific journal),  ISSN  0470-8105

Fbxo45, a Novel Ubiquitin Ligase, Regulates Synaptic Activity

Tada, Hirobumi, Okano, Hirotaka James, Takagi, Hiroshi, Shibata, Shinsuke, Yao, Ikuko, Matsumoto, Masaki, Saiga, Toru, Nakayama, Keiichi I., Kashima, Haruo, Takahashi, Takuya, Setou, Mitsutoshi, Okano, Hideyuki

JOURNAL OF BIOLOGICAL CHEMISTRY 285 ( 6 ) 3840 - 3849 2010.02

Research paper (scientific journal),  ISSN  0021-9258

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