Details of a Researcher - Okano, Hideyuki

Papers - Okano, Hideyuki

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Cell types to order: temporal specification of CNS stem cells

Okano, Hideyuki, Temple, Sally

CURRENT OPINION IN NEUROBIOLOGY 19 ( 2 ) 112 - 119 2009.04

Research paper (scientific journal), ISSN 0959-4388

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Musashi-1, an RNA-binding protein, is indispensable for survival of photoreceptors

Susaki, Kanako, Kaneko, Jun, Yamano, Yuka, Nakamura, Kenta, Inami, Wataru, Yoshikawa, Taro, Ozawa, Yoko, Shibata, Shinsuke, Matsuzaki, Osamu, Okano, Hideyuki, Chiba, Chikafumi

EXPERIMENTAL EYE RESEARCH 88 ( 3 ) 347 - 355 2009.03

Research paper (scientific journal), ISSN 0014-4835

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The Role of Uterine Smooth Muscle Stem Cells, Isolated Based on Cell Surface Markers, in Myometrial Remodeling in the Pregnant Uterus

Ono, Masanori, Maruyama, Tetsuo, Kajitani, Takashi, Uchida, Hiroshi, Oda, Hideyuki, Nishikawa, Sayaka, Kagami, Maki, Arase, Toru, Nagashima, Takashi, Masuda, Hirotaka, Morikawa, Satoru, Mabuchi, Yo, Okano, Hideyuki, Matsuzaki, Yumi, Yoshimura, Yasunori

REPRODUCTIVE SCIENCES 16 ( 3 ) 296A - 297A 2009.03

Research paper (scientific journal), ISSN 1933-7191

Adipogenic differentiation of human induced pluripotent stem cells: Comparison with that of human embryonic stem cells

Taura, Daisuke, Noguchi, Michio, Sone, Masakatsu, Hosoda, Kiminori, Mori, Eisaku, Okada, Yohei, Takahashi, Kazutoshi, Homma, Koichiro, Oyamada, Naofumi, Inuzuka, Megumi, Sonoyama, Takuhiro, Ebihara, Ken, Tamura, Naohisa, Itoh, Hiroshi, Suemori, Hirofumi, Nakatsuji, Norio, Okano, Hideyuki, Yamanaka, Shinya, Nakao, Kazuwa

FEBS LETTERS 583 ( 6 ) 1029 - 1033 2009.03

Research paper (scientific journal), ISSN 0014-5793

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The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats

Takenaga Mitsuko, Ohta Yuki, Tokura Yukie, Hamaguchi Akemi, Shudo Koichi, Okano Hideyuki, Igarashi Rie

Biological and Pharmaceutical Bulletin 32 ( 2 ) 225 - 231 2009.02

ISSN 0918-6158

The present study investigated the effect of 4[(5,6,7,8-tetrahydro-5,5,8,8, -tetramethyl-2-naphthalenyl)car-bamoyl] benzoic acid (Am-80), a synthetic retinoid, on spinal cord injury (SCI) in rats. Treatment with Am-80 (orally and subcutaneously) significantly promoted recovery from SCI-induced motor dysfunction. On day 28 after injury, the lesion cavity was markedly reduced, while the expression of myelin basic protein (MBP; myelin), βIIItubulin (neuron), and glial fibrillary acidic protein (GFAP; astrocyte) was increased, in comparison with SCI controls. Interestingly, expression of neurotrophin receptor, tyrosine kinase B (TrkB) was over 3-fold higher after Am-80 treatment than in SCI controls. A lot of TrkB-positive cells as well as brain-derived neurotrophic factor (BDNF)-positive ones were observed around the injured site. Am-80 (10 μm) combined with BDNF (100ng/ml) promoted extensive neurite outgrowth and TrkB gene expression by cultured SH-SY5Y cells, as did all-trans retinoic acid (ATRA). Thymidine incorporation was dramatically suppressed, but there was little effect on cell viability. These findings suggest that Am-80 has the potential to be used for treating neurodegenerative disorders, including SCI. Its efficacy may be partly ascribed to promotion of cell viability and differentiation of neural stem cells through increased TrkB expression. © 2009 Pharmaceutical Society of Japan.

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Visualization of peripheral nerve degeneration and regeneration: Monitoring with diffusion tensor tractography

Takagi, Takehiko, Nakamura, Masaya, Yamada, Masayuki, Hikishima, Keigo, Momoshima, Suketaka, Fujiyoshi, Kanehiro, Shibata, Shinsuke, Okano, Hirotaka James, Toyama, Yoshiaki, Okano, Hideyuki

NEUROIMAGE 44 ( 3 ) 884 - 892 2009.02

Research paper (scientific journal), ISSN 1053-8119

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Development of mesenchymal stem cells partially originate from the neural crest

Morikawa, Satoru, Mabuchi, Yo, Niibe, Kunimichi, Suzuki, Sadafumi, Nagoshi, Narihito, Sunabori, Takehiko, Shimmura, Shigeto, Nagai, Yasuo, Nakagawa, Taneaki, Okano, Hideyuki, Matsuzaki, Yumi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379 ( 4 ) 1114 - 1119 2009.02

Research paper (scientific journal), ISSN 0006-291X

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The Effect of Am-80, a Synthetic Retinoid, on Spinal Cord Injury-Induced Motor Dysfunction in Rats

Takenaga, Mitsuko, Ohta, Yuki, Tokura, Yukie, Hamaguchi, Akemi, Shudo, Koichi, Okano, Hideyuki, Igarashi, Rie

BIOLOGICAL & PHARMACEUTICAL BULLETIN 32 ( 2 ) 225 - 231 2009.02

Research paper (scientific journal), ISSN 0918-6158

Suppression of Oct4 by Germ Cell Nuclear Factor Restricts Pluripotency and Promotes Neural Stem Cell Development in the Early Neural Lineage

Akamatsu, Wado, DeVeale, Brian, Okano, Hideyuki, Cooney, Austin J., van der Kooy, Derek

JOURNAL OF NEUROSCIENCE 29 ( 7 ) 2113 - 2124 2009.02

Research paper (scientific journal), ISSN 0270-6474

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Evaluation of Human Fetal Neural Stem/Progenitor Cells as a Source for Cell Replacement Therapy for Neurological Disorders: Properties and Tumorigenicity After Long-Term In Vitro Maintenance

Ogawa, Daisuke, Okada, Yohei, Nakamura, Masaya, Kanemura, Yonehiro, Okano, Hirotaka James, Matsuzaki, Yumi, Shimazaki, Takuya, Ito, Mamoru, Ikeda, Eiji, Tamiya, Takashi, Nagao, Seigo, Okano, Hideyuki

JOURNAL OF NEUROSCIENCE RESEARCH 87 ( 2 ) 307 - 317 2009.02

Research paper (scientific journal), ISSN 0360-4012

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Mouse Embryonic Stem Cells Give Rise to Gut-Like Morphogenesis, Including Intestinal Stem Cells, in the Embryoid Body Model

Konuma, Noriyoshi, Wakabayashi, Kumiko, Matsumoto, Taro, Kusumi, Yoshiaki, Masuko, Takayuki, Iribe, Yuji, Mitsumata, Masako, Okano, Hideyuki, Kusafuka, Takeshi, Mugishima, Hideo

STEM CELLS AND DEVELOPMENT 18 ( 1 ) 113 - 125 2009.01

Research paper (scientific journal), ISSN 1547-3287

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Regeneration of the central nervous system using iPS cell-technologies

Okano Hideyuki

Clinical Neurology 49 ( 11 ) 825 - 826 2009

ISSN 0009-918X

Induced pluripotent stem (iPS) cells are pluripotent stem cells directly reprogrammed from cultured mouse fibroblast by introducing Oct3/4, Sox2, c-Myc, and Klf4. Cells obtained using this technology, which allows the ethical issues and immunological rejection associated with embryonic stem (ES) cells to be avoided, might be a clinically useful source for cell replacement therapies. We found that secondary neurospheres (SNSs) generated from various mouse iPS cell showed their neural differentiation capacity and teratoma formation after transplantation into the brain of immunodeficient NOD/SCID mice. We found that origin (source of somatic cells) of the iPS cells are the crucial determinant for the potential tumorigenicity of iPS-derived neural stem/progenitor cells and that their tumorigenicity results from the persistent presence of undifferentiated cells within the SNSs. Surprisingly, SNSs derived from c-Myc minusiPS cells generated without drug selection showed robust tumorigenesis, in spite of their potential to contribute adult chimeric mice without tumor formation. Furthermore, we examined whether the transplantation of non-tumorigenic Nanog-iPS-derived SNSs into mouse spinal cord injury (SCI) model could promote locomotor function recovery. As a result, we found that properly pre-evaluated iPS clone-derived neural stem/progenitor cells may be a promising cell source for future transplantation therapy of SCI.

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Analysis of spinal cord injury using diffusion MRI

Nakamura, Masaya, Fujiyoshi, Kanehiro, Hikishima, Keigo, Toyama, Yoshiaki, Okano, Hideyuki

NEUROSCIENCE RESEARCH 65 S35 - S35 2009

Research paper (scientific journal), ISSN 0168-0102

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COMPARATIVE STUDY OF DIFFERENT ADMINISTRATIONS OF THE NEURAL STEM CELLS FOR SPINAL CORD INJURY IN MICE

Takahashi, Yuichiro, Nakamura, Masaya, Tuji, Osahiko, Kumagai, Gentaro, Hara, Chikako, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 442 - 442 2009

Research paper (scientific journal), ISSN 1880-6546

A ROLE FOR RNA-BINDING PROTEIN MUSASHI 1 IN REGULATING THE AXONAL MIDLINE CROSSING

Kuwako, Ken-ichiro, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 342 - 342 2009

Research paper (scientific journal), ISSN 1880-6546

Epigenetic mechanisms regulating neural cell fate determination

Nakashima Kinichi, Kohyama Jun, Namihira Masakazu, Gage Fred H., Okano Hideyuki, Sawamoto Kazunobu

No To Hattatsu 41 ( 6 ) 411 - 414 2009

ISSN 0029-0831

Neural stem/progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes, and oligodendrocytes. It has become apparent that intracellular epigenetic modification including DNA methylation, in concert with extracellular cues such as cytokine signaling, is deeply involved in specifiying the fate of NSCs/NPCs by defining cell-type specific gene expression. However, it is still unclear how differentiated neural cells retain their specific attributes by repressing cellular properties characteristic of other lineages. In previous work, we have shown that methyl-CpG binding protein transcriptional repressors (MBDs), which were expressed predominantly in neurons in the central nervous system, inhibited astrocyte-specific gene expression by binding to highly methylated regions of their target genes. Here we report that oligodendrocytes, which do not express MBDs, can transdifferentiate into astrocytes both in vitro (cytokine stimulation) and in vivo (ischemic injury) through the activation of the JAK/STAT signaling pathway. These findings suggest that differentiation plasticity in neural cells is regulated by cell-intrinsic epigenetic mechanisms in collaboration with ambient cell-extrinsic cues.

ROLE AND MECHANISMS OF REACTIVE ASTROCYTE S MIGRATION AFTER SPINAL CORD INJURY

Renault-Mihara, Francois, Mukaino, Masahiko, Nakamura, Masaya, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 341 - 341 2009

Research paper (scientific journal), ISSN 1880-6546

COMPARATIVE STUDY OF DIFFERENT ADMINISTRATIONS OF THE NEURAL STEM CELLS FOR SPINAL CORD INJURY IN MICE

Takahashi, Yuichiro, Nakamura, Masaya, Tuji, Osahiko, Kumagai, Gentaro, Hara, Chikako, Toyama, Yoshiaki, Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 442 - 442 2009

Research paper (scientific journal), ISSN 1880-6546

SENSORY NEURAL NETWORK FORMATION WITH RNA BINDING PROTEIN MUSASHI2 DEFICIENT MICE

Shibata, Shinsuke, Sakakibara, Shin-Ichi, Furue, Hidemasa, Yoshimura, Megumu, Takagi, Takehiko, Ohkuma, Rika, Kuwako, Ken-Ichiro, Okano, Hirotaka J., Okano, Hideyuki

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 337 - 337 2009

Research paper (scientific journal), ISSN 1880-6546

ANALYSIS OF CELL SURFACE MOLECULES WITH COMPLEX TYPE N-GLYCANS ON NEURAL STEM CELLS

Hamanoue, Makoto, Okano, Hirotaka J., Okano, Hideyuki, Takamatsu, Ken

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 291 - 291 2009

Research paper (scientific journal), ISSN 1880-6546

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