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Papers - Oguma, Yuko

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身体活動のすすめ今求められるシステムズアプローチ、歯科とのつながりを考える

小熊祐子, 齋藤義信

日本歯科医師会雑誌 73 293 - 304 2020

地域在住高齢者におけるポリファーマシーと抗コリン作動薬及び鎮静作用薬が身体・認知・精神に与える影響の評価 The Kawasaki Wellbeing Project

田中あさひ, 新井康通, 平田匠, 阿部由紀子, 小熊祐子, 漆原尚巳

日本老年医学会雑誌 ((一社)日本老年医学会) 56 ( 4 ) 504 - 515 2019.10

Joint Work, ISSN 0300-9173

目的:本研究の目的は高齢者におけるポリファーマシー,抗コリン作動薬及び鎮静作用薬の使用による薬剤負荷の影響を調査することである.方法:川崎市在住非介護高齢者コホートThe Kawasaki Wellbeing Projectにて2017年3月から12月までに参加した396名を対象とした.ベースライン時の薬剤情報から薬剤数を算出,抗コリン作動薬及び鎮静作用薬に該当する薬剤から対象者のDrug Burden Index(DBI)を算出し薬剤負荷とした.アウトカム指標であるADL,IADL,MMSE,J-CHS,EQ5D5Lについて多変量回帰分析を行い,使用薬剤数又はDBIとの関連性を検討した.調整には性別,年齢,疾患数,教育歴,飲酒歴,喫煙歴を用いた.結果:解析の対象となった389名において年齢の中央値は86歳,男性は48%にあたる187名であった.ポリファーマシーに該当した対象者は243名(62%)であり,DBI該当薬の使用者は142名(36.5%)となった.各アウトカム指標の結果から本集団は身体機能,QOLが高く,フレイルのリスクの低い集団であることが分かった.使用薬剤数はJ-CHS(β:0.04),EQ5D5L(-0.01)と有意に負の関連を示し,DBIスコアはEQ5D5L(-0.04)と有意に負に関連していた.結論:調査結果から本集団は一般的な高齢者と比較すると身体機能及び認知機能の高い健康な集団であることが示された.しかし,ポリファーマシー及び抗コリン作動薬及び鎮静作用薬による薬剤負荷は高齢者のフレイル,QOLの低下と関連していることが示唆された.今後はより大規模で多角的な調査項目を含めた長期間の観察を行うことが望ましい.(著者抄録)

Drug burden of polypharmacy and anticholinergic/sedative drugs and physical/cognitive/mental related outcomes of the community-dwelling elderly people: The Kawasaki well-being project

Asano Ringo, Tanaka Asahi, Arai Yasumichi, Hirata Takumi, Abe Yukiko, Oguma Yuko, Urushihara Hisashi

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 28 293 - 293 2019.08

Joint Work, ISSN 1053-8569

食育に役立つ配膳を基本としたたまごの大きさを基準に摂取量を回答する食事調査票「たまごの大きさで数える食事チェックシート-簡単版-」の開発

鈴木亜夕帆, 小熊祐子, 東宏一郎, 渡邊智子

千葉県立保健医療大学紀要 (千葉県立保健医療大学) 10 ( 1 ) 97 - 105 2019.03

Joint Work, ISSN 1884-9326

摂取量をたまごの大きさで回答する「たまごの大きさで数える食事チェックシート」の簡単版を開発した.質問用紙は,両面カラー印刷,仕上がりA4版サイズ,二つ折,全4ページの様式とした.質問用紙は,表紙,回答方法の説明,食事内容回答,生活習慣回答ページの4つの構成とした.食事内容回答ページは,見開きページにして一覧で見ることができるようにした.個人結果票は,カラー印刷,A4版サイズ,1枚とし,食事配膳区分を中心とした結果表示とした.摂取量は,たまごの大きさでどのくらいか回答できるため,摂取重量が不明でも本人が回答しやすいものであること,食事配膳区分でのみ回答をするため,質問の項目が少なくなり,食事に興味があまりない方への食事調査で回答のハードルを下げること,食育イベント等で来場した方へ短時間で結果を配布することが可能になると考えられる.妥当性と再現性は,現在解析中である.(著者抄録)

Drug burden of polypharmacy and anticholinergic/sedative drugs and physical/cognitive/mental related outcomes of the community-dwelling elderly people: The Kawasaki well-being …

R Asano, A Tanaka, Y Arai, T Hirata, Y Abe, Y Oguma, H Urushihara

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 28, 293-293 2019

Joint Work

Classification of body components and activity patterns by data mining of health care data.

Shunichi Nomura, Michiko Watanabe, Yuko Oguma

Oukan (Transdisciplinary Federation of Science and Technology) 13 ( 1 ) 15 - 22 2019

Research paper (scientific journal), Joint Work, ISSN 1881-7610

Healthcare data is rapidly increasing as healthcare smart devices are developed. However, statistical analysis of healthcare big data is difficult due to heterogeneity in data quality and missing data. For such data, data mining methods such as clustering and dimension reduction may be useful as their preliminary analysis. In this paper, we show two illustrative applications; one is a principal component analysis of body composition data and the other is a latent topic analysis of hourly step-count dataset recorded by physical activity monitors. From those analyses, we proposed independent indices of body size and hidden obesity and extracted some diurnal patterns in ambulatory activities.

Effects of polypharmacy and anticholinergic/sedative drugs on the physical/cognitive/mental related outcomes of community-dwelling elderly people: The Kawasaki Wellbeing Project

A Tanaka, Y Arai, T Hirata, Y Abe, Y Oguma, H Urushihara

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 56 (4), 504-515 (The Japan Geriatrics Society) 56 ( 4 ) 504 - 515 2019

ISSN 03009173

Aim: To assess the burdens of polypharmacy and the drug burden index in community-dwelling elder people.Methods: The survey was conducted on 396 participants who participated in The Kawasaki Wellbeing Project from March to December 2017. We investigated the associations between the drug burden and the physical/cognitive/mental outcomes. The drug burden was determined by calculating the number of medications and the drug burden index (DBI) based on the use of anticholinergic and sedative drugs. A multivariate regression analysis was conducted for the outcome measures ADL, IADL, MMSE, J-CHS, and EQ5D5L after adjusting for the sex, age, number of diseases, education level, smoking history, and alcohol history.Results: A total of 389 subjects were analyzed, the mean age of the population was 86 years old, and 187 people (48%) were male. Polypharmacy was reported in 243 people (62%), and DBI exposure was reported for 142 people (36.5%). We found that this population was physically healthy, with a median ADL of 100, and had high quality of life, with a median EQ5D5L of 0.895. Polypharmacy was found to be related to the J-CHS (β: 0.04) and EQ5D5L (−0.01). The DBI was also related to the EQ5D5L (−0.04).Conclusion: These results showed that even though this population was healthier than the general Japanese elderly population, the drug burden of polypharmacy and high dosages of anticholinergic/sedative drugs exerted significant negative effects on frailty and the quality of life. Additional research should be conducted to investigate the long-term effects of polypharmacy and anticholinergic/sedative drugs on elderly people.

健康長寿社会における身体活動と健康ー「ふじさわプラス・テン」の取り組みを通してー

小熊祐子, 齋藤義信

予防医学 60 21 - 25 2019

健康長寿社会における健康支援-アクティブシニアを目指して健康長寿社会における身体活動と健康-「ふじさわプラス・テン」の取り組みを通して

Y OGUMA, Y SAITO

予防医学, 21-25 2019

Population-based approaches to promote physical activity: the Fujisawa +10 project

SAITO Yoshinobu, TAJIMA Takayuki, SHIBA Chisato, OGUMA Yuko

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 27 ( 1 ) 71 - 81 2019

Accepted, ISSN 1340-2560

Objective: We introduced the physical activity promotion project "Fujisawa +10" and aimed to provide reference information regarding evaluation methods and research findings translating to health education and promotion.Contents: We conducted a community-wide intervention to promote physical activity based on the Japanese physical activity guideline (Active Guide) in cooperation with Fujisawa city. The intervention's key message was "Plus Ten (+10: be active for 10 more minutes than now). We implemented this project in 4 districts for 2 years from 2013, and evaluated its pre- and post-implementation effects using population-based surveys (Phase 1). The RE-AIM evaluation revealed a low degree of reaching residents and improved active guide knowledge, but unchanged physical activity levels. From 2015, we applied it to all districts, considering the Phase 1 results (Phase 2). We aimed to improve the degree of reach and focused on group exercise interventions intended to spread to residents. Elderly individuals who performed the group exercise showed improved physical fitness one year later and consistent physical activity and cognitive function. Then, the number of participants increased by 21% in a year. We extracted features of rules, roles, and tools as important aspects of smooth group activities, and created manuals. These findings are still utilized in Fujisawa city health promotion.Conclusion: This project involved RE-AIM evaluations and strategy improvement. Our findings were translated into the city's policy and scaled up. In Japan, in addition to increases in the practices, it is necessary to further disseminate and implement evaluation frameworks such as the RE-AIM model.

Physical activity, exercise, and health promotion for cancer survivors

OGUMA Yuko, SAITO Yoshinobu, TAJIMA Takayuki

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 27 ( 1 ) 109 - 114 2019

ISSN 1340-2560

Introduction: Physical activity is known to reduce the risk of cancer morbidity and mortality, and to give the health benefits for cancer survivors. For example, after receiving cancer diagnosis, appropriate physical activity can improve prognosis afterwards. Evidence is available to show the risk of cancer-related mortality falls to 50% in the group that continues exercise after a cancer diagnosis. Previous interventional studies also show improvement in physical fitness, quality of life, mood, reduced anxiety and depression/fatigue, an effect on body image/body composition, and an improvement in biomarkers related to cancer risk and outcome.Current status of physical activities: Based on this evidence, the American Cancer Society/American College of Sports Medicine recommends that cancer survivors engage in 150 minutes per week of moderate-intensity aerobic physical activity (or 75 minutes/week of vigorous-intensity aerobic physical activity) and two strength training sessions per week, as well as decreased sedentary time. However, <30% of persons diagnosed with cancer are reported to meet the recommended levels. To maintain high physical activity in real life settings, a feasible strategy in society should be established.Toward Social Implementation: In the 2017 Clinical Practice Guidelines (Canada), evidence supports the promotion of exercise in a group or supervised settings. For sustainable engagement in physical activity, it is important to be able to exercise under guidance and to promote physical activities in daily life, depending on the situation.

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運動開始前の健康スクリーニング～誰が何をするのか～

小熊祐子

日本臨床運動療法学会誌 20 27 - 31 2019

健康長寿社会における身体活動と健康－「ふじさわプラス・テン」の取り組みを通して－

小熊祐子, 齋藤義信

予防医学 60 21 - 25 2019

脳心血管病予防に関する包括的リスク管理チャート2019年版について

小熊祐子, 井上茂, 永富良一

日内会誌 108 ( 5 ) 1024 - 1070 2019

Prevalence of Metabolic Syndrome and Lifestyle Characteristics by Business Type among Japanese Workers in Small- and Medium-sized Enterprises

Hozawa, H., Takeuchi, A. and Oguma, Y.

Keio J Med (Keio Journal of Medicine) 68 ( 3 ) 54 - 67 2018.12

Joint Work, ISSN 0022-9717

This cross-sectional study investigated the associations of business type with the prevalence of metabolic syndrome (MetS) and lifestyle characteristics among workers in small- and medium-sized enterprises. In total, data from 167,736 workers (114,746 men and 52,990 women) who participated in health checkups in 2013 were analyzed using multilevel logistic regression models. The odds ratios (ORs) of having MetS, defined based on the criteria of the joint interim statement, were significantly higher in employees of transportation businesses (reference OR =1) than in other business types among men (OR: 0.67-0.85) and similar result was observed among women (OR: 0.70-0.88). The prevalence of a smoking habit was significantly higher in transportation workers than in employees of other businesses for both men and women. Furthermore, male transportation workers were more likely to skip breakfast, engage in <1 h/day of walking, walk at a slower speed, and eat dinner just before going to bed. Female transportation workers were more likely to have gained 10 kg since the age of 20 years. In conclusion, the prevalence of MetS was higher in transportation workers than in workers from other businesses; the associated risk factors may also vary by sex. To effectively promote public health, the labor environment, such as the business type, should be considered.

Elevated creatine kinase and lactic acid dehydrogenase and decreased osteocalcin and uncarboxylated osteocalcin are associated with bone stress injuries in young female athletes

T Miyamoto, Y Oguma, Y Sato, T Kobayashi, E Ito, M Tani, K Miyamoto, ...

Scientific reports 8 (1), 18019 (Scientific Reports) 8 ( 1 ) 18019 - 18019 2018.12

Joint Work, ISSN 2045-2322

© 2018, The Author(s). Stress fractures are a limitation for athletes not only in sports performance but in activities of daily living. Thus, preventing them is crucial. In female athletes, a triad of symptoms including low energy availability, functional hypothalamic amenorrhea and osteoporosis are considered risk factors for stress injuries, but biomarkers predictive of these outcomes are not available. Here, we evaluated 56 female university athletes and found that 13 had a history of stress bone injuries. Logistic regression analysis demonstrated that dysmenorrhea including amenorrhea, but not reduced food intake or body weight loss, was significantly associated with stress injuries. When we subdivided subjects into stress fracture and non-fracture groups, we found that serum levels of creatine kinase (CK) and lactic acid dehydrogenase (LDH) were significantly higher in the fracture group, while osteocalcin and uncarboxylated osteocalcin (ucOC), which are bone forming parameters, significantly decreased. Low vitamin D levels are associated with stress fractures, but serum vitamin D levels were higher in fracture compared to non-fracture subjects. We followed up 32 subjects for

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Relationship of objectively measured physical activity and physical function of community-dwelling very old in Kawasaki, Japan: baseline assessment of Kawasaki well-being prospective cohort study

Oguma Yuko, Tajima Takayuki, Saito Yoshinobu, Fukui Shogo, Kibayashi Yayoi, Yoshida Natsuko, Ishida Hiroyuki, Hirata Takumi, Abe Yukiko, Arai Yasumichi

JOURNAL OF PHYSICAL ACTIVITY & HEALTH 15 ( 10 ) S34 - S34 2018.10

ISSN 1543-3080

Physical Activity Among Postoperative Esophageal Cancer Patients

Ichijo, Y., Takeda, Y., Oguma, Y., Kitagawa, Y., Takeuchi, H. and Doorenbos, A. Z.

Cancer Nurs (Cancer nursing) 42 ( 6 ) 501 - 508 2018.09

Joint Work, ISSN 0162-220X

BACKGROUND: Previous literature has reported that regular physical activity enhances health-related quality of life for cancer patients. However, there is a lack of studies that focus on physical activity among postoperative esophageal cancer patients. OBJECTIVE: The aims of this study were to (1) describe the prevalence of physical activity among postoperative esophageal cancer patients, (2) explore variables related to physical activity (demographics, nutrition, dysphagia, and health-related qualify of life), and (3) examine potential reasons for inactivity among participants who scored low using case studies. METHODS: In this cross-sectional design, physical activity was evaluated by the Japanese version of the International Physical Activity Questionnaire. Variables were analyzed using Spearman rank correlation coefficients, Mann-Whitney U tests, or Fisher exact tests. RESULTS: Fifty-eight patients participated in this study; 79% met the recommended physical activity guidelines. Present occupational status and past leisure-time physical activity behavior before the cancer diagnosis were related to current leisure-time physical activity and meeting the guidelines postoperatively. Participants who scored 0 (little or no activity) in the questionnaire also scored low in health-related quality of life. CONCLUSIONS: Participants performed especially well in physical activity related to leisure time and transportation. Positive reinforcement is needed for patients who perform adequate levels of physical activity, and reviewing the benefits of regular physical activity is encouraged for all. IMPLICATIONS FOR PRACTICE: Occupational status and past leisure-time physical activity before diagnosis can be indicators for promoting physical activity among postoperative esophageal cancer patients. Inactive participants should be supported to promote both physical activity and health-related qualify of life.

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高齢者地域コミュニティのグループ運動継続に関わる特徴

柴, 知里, 齋藤, 義信, 今村, 晴彦, 田中, あゆみ, 土村, 里佳 and 小熊, 祐子

日本健康教育学会誌 (日本健康教育学会) 26 ( 2 ) 144 - 154 2018.05

Joint Work, ISSN 1340-2560

目的:高齢者地域コミュニティのグループ運動継続に関わる特徴を把握する。事業/活動内容:対象は藤沢市で実施中の身体活動促進のための地域介入研究に参加し、6ヵ月間グループ運動を継続している8グループ(120名)である。研究参加時、6ヵ月後時点で質問紙調査、体力測定、認知機能評価を行った。運動プログラムやモニタリングツールを提供し、定期的なフォローアップや交流会、グループワークを行った。事業/活動評価:(1)リーダーの特徴と協力者の有無および協力の主体性で8グループを4群に分類し、質問紙による身体活動量、精神的健康、地域とのつながり、個人要因を比較した。(2)グループ向け質問紙、交流会、グループワークの質的情報から、グループの特徴を比較した。結果を統合してコミュニティづくりに重要なルール(自生した規則や制度)、ロール(自発的な役割)、ツール(道具や資源)の観点からグループの特徴を把握した。活動基盤となるルールは、全グループ共通のル

Maintenance Of Physical Activity Level And Dissemination Of "Plus Ten" Message In Community-based Group Exercise

Saito Yoshinobu, Oguma Yuko, Tajima Takayuki, Tanaka Ayumi, Kibayashi Yayoi, Shiba Chisato, Miyachi Motohiko, Takebayashi Toru

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 50 ( 5 ) 62 - 63 2018.05

Joint Work, ISSN 0195-9131

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