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Papers - Oguma, Yuko

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What policies do local governments use to promote physical activity? A comparative analysis of municipalities from 4 EU countries and Japan

S Messing, AN Racine, N Takeda, T Onatsu, K Tuunanen, A Papiu, ...

International journal of health policy and management 2025

Cardiorespiratory fitness and body mass index on metabolic syndrome in middle-aged Japanese adults under national health guidance: a cross-sectional study

X Zhai, SS Sawada, S Kurosawa, S Koriyama, SA Dimitroff, S Sato, ...

BMC public health 24 (1), 2050 24 ( 1 ) 2050 - 2050 2024.12

Objectives: Poor cardiorespiratory fitness (CRF) and high body mass index (BMI) increased the risk of developing metabolic Syndrome (MetS) mostly in Caucasians. However, the sex-specific combined association of CRF and BMI on MetS considering health-related behaviors has yet to be thoroughly examined in Japanese. This study aims to investigate the sex-specific independent and combined associations of CRF and BMI with MetS in middle-aged Japanese adults. Methods: 421 participants were included in this cross-sectional study. CRF was estimated using a submaximal cycle ergometer. CRF and BMI were respectively divided into three categories according to tertile distribution. MetS was diagnosed based on five risk factors: waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, and fasting glucose. Multivariable logistic regression models were used to estimate independent and combined association of CRF and BMI with MetS. Results: Results showed that 154 (57.5%) and 70 (45.8%) of men and women had MetS, respectively. Compared to men with lower CRF or higher BMI, men with middle and higher CRF or middle and lower BMI were less likely to have MetS. Compared with ‘unfit and higher BMI’ group, ‘unfit and lower BMI’, ‘fit and higher BMI’, and ‘fit and lower BMI’ groups in men showed statistically significant decreased prevalences of MetS. However, no significant associations were found in women. Conclusions: This study found significant independent and combined associations of CRF and BMI with MetS only in men, but not in women. However, prospective studies are warranted to confirm sex-specific associations of CRF and BMI with MetS.

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Sustainability of community-based practical research toward extending healthy life expectancy

HARADA Kazuhiro, UEMURA Kazuki, SAITO Yoshinobu, NEMOTO Yuta, OGUMA Yuko

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 32 ( 4 ) 330 - 334 2024.11

ISSN 13402560

Older adults hope to promote good health and extend their longevity, which will contribute to a better-aging society. The 32nd Annual Meeting of the Japanese Society for Health Education and Promotion held a symposium titled “Sustainability of Community-based Practical Research toward Extending Healthy Life Expectancy.” The aim of this symposium was to introduce several studies conducted in community-based practical settings to examine efforts for promoting health and extending longevity among older adults. After a brief introduction by the chairperson, three speakers (Dr. Uemura, Dr. Saito, and Dr. Harada) presented their own researches. Dr. Uemura proposed that health education through active learning (e.g., in-class group work, out-of-class homework and practice) could promote health behavior change and prevent frailty among older adults. Dr. Saito presented a multi-strategic community-wide intervention (e.g., distributing information, providing educational lectures and classes, supporting exercise communities) implemented in collaborations with a local municipal office, university, and local healthcare foundation that could elevate physical activity levels among adults of all ages, including older adults, in a community. Dr. Harada showed that a university-led event-based community program could increase neighborhood social networks; further, an increase in social networks could have a desirable influence on mental well-being among older adults. As the designated speaker, Dr. Oguma referred to the importance of a systems approach for the sustainability of community-based practical research.

Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study

Tajima T., Oguma Y., Saito Y., Abe Y., Lee I.M., Arai Y.

Journal of Frailty and Aging 13 ( 4 ) 413 - 420 2024.11

ISSN 22601341

Background: While physical activity (PA) can reduce physical frailty, the specific intensity and duration of PA required to prevent frailty are yet to be defined. Objectives: This study aimed to investigate the relationship between objectively measured PA or sedentary behavior (SB) and physical frailty and to explore the theoretical effect of replacing SB with different intensities of PA on the risk of frailty. Design: Cross-sectional study. Setting: Community-based assessments. Participants: Independently living adults aged 85–89 years participating in the Kawasaki Aging and Wellbeing Project. Measurements: PA was measured using a triaxial accelerometer for a minimum of 10 h per day over a minimum of 3 days. Physical frailty was measured using the revised Japanese version of the Cardiovascular Health Study criteria. Physical frailty was classified as non-frail, pre-frail, and frail. The relationship between PA and frailty was assessed using analysis of covariance. The effect of replacing SB with light-intensity PA (LPA) or moderate-to-vigorous-intensity PA (MVPA) on the risk of frailty was estimated using multinomial logistic regression and an isotemporal substitution model. Results: The analysis included 1004 participants (503 men and 501 women) of whom 242 were classified as frail. The mean step count, MVPA, and LPA were lower, and SB was higher in the frail group than in the non-frail group. SB replacement with MVPA for 10 min/day was associated with a significantly lower odds of frailty (odds ratio [95% confidence interval]: pre-frail men, 0.86 [0.77, 0.96]; frail men, 0.70 [0.60, 0.83]; pre-frail women, 0.77 [0.66, 0.90], frail women, 0.59 [0.47, 0.75]). SB replacement with LPA was not significantly associated with frailty odds in men or women. Conclusions: Replacing 10 min of SB with MVPA was associated with lower risk of frailty in adults aged 85–89 years. These findings require confirmation in longitudinal and intervention studies.

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Impact of Housing Conditions on Physical Fitness Changes in College Rugby Players during Team Training Interruptions: A retrospective longitudinal study

HIRATA Akihiro, HOSHINO Yuki, KOHTAKE Naohiko, OGUMA Yuko

Japanese Journal of Athletic Training (Japanese Society for Athletic Training) 10 ( 1 ) 1 - 10 2024.10

ISSN 24326623

The global outbreak of novel coronavirus infection in the winter of 2020 led to city lockdowns and curfews in many parts of the world, forcing university athletes to suspend training. De-training negatively affects athletic performance. In school sports, temporary closures due to infectious diseases often occur yearly. Therefore, this study aimed to clarify the differences in the changes in various physical fitness factors between two different residential environments during the suspension of team activities. The observation period was 7 months, from March to September 2020. The baseline period was defined as the period before the voluntary suspension of team activities (March), the de-training period was the timeframe of suspension of team activities (April-May), and the follow-up period was defined as the period after the resumption of team practice (June-September). The study participants included 17 dormitory students and 14 home-schooled students in a university rugby team. The dormitories were equipped with training equipment and space for minimal training. The team staff provided a training program for both dormitory and non-dormitory students, which could be followed at home during periods when team practices were suspended. This study showed sig-nificant differences between dormitory and home-schooled students in the maximum lifting weight measurement of narrow chinning at baseline and after de-training. Other physical fitness factors did not differ significantly between groups or measurement periods. Although this study sample size was small and sufficient power could not be obtained, home weight training could maintain a certain level of maximum muscle strength as in the present study, suggesting that preparation for back exercises that can be performed at home is essential for the back muscles.

The Achievement of the SDGs through Physical Activity and Sports

OGUMA Yuko

Environmental Information Science (Center for Environmental Information Science) 53 ( 3 ) 29 - 33 2024.10

ISSN 03896633

身体活動促進と SDGs 達成を関連づけたシステムズアプローチの重要性について論じた。慶應スポーツ SDGs センターでは，スポーツを通じた地球と人々のウェルビーイング共存を目指す活動が進行中である。世界保健機関の「身体活動に関する世界行動計画 2018?2030（GAPPA）」を基に，身体活動の促進が健康，経済，社会，環境へ多様な効果をもたらすとされる。日本国内では「健康日本 21（第三次）」や地域介入事例「ふじさわプラス・テン」などが推進され，身体的・精神的・社会的健康を統合的に改善する。これらの取り組みが，持続可能な社会の構築に向けて貢献することが期待される。

Efficacy of exercise with the hybrid assistive limb lumbar type on physical function in mobility-limited older adults: A 5-week randomized controlled trial

Y Saito, S Nakamura, T Kasukawa, M Nagasawa, Y Oguma, H Narimatsu

Experimental gerontology 195, 112536 195 112536 - 112536 2024.10

ISSN 05315565

Background: Sarcopenia and frailty often worsen in older adults because of declines in activities of daily living and social connections that are associated with chronic diseases and traumatic injuries such as falls and fractures. Exercise intervention for sarcopenia can take >3 months to improve muscle mass, muscle strength, and walking speed. Thus, a specialized intervention system for shorter periods of time is needed. In this study, we aimed to evaluate the short-term efficacy of an exercise program using the wearable cyborg Hybrid Assistive Limb (HAL) lumbar type in physical function in mobility-limited older adults who do not require transition to long-term care. Methods: This randomized, single-blind, parallel-group study involved 79 community-dwelling older adults with physical frailty or locomotive syndrome assigned to an intervention group (n = 40) with the HAL lumbar type exercise program or a control group (n = 39) without the exercise program. The intervention group underwent trunk training (including trunk and hip flexion, standing and sitting from a single sitting position, and squats) and gait training (treadmill and parallel bars) twice a week for 5 weeks while wearing the HAL lumbar type. The 10-m usual and maximum walking speeds, Timed Up and Go test results, 5-times chair-standing test results, 5-question Geriatric Locomotive Function Scale (GLFS-5) scores, body-fat percentage, and muscle mass were measured before and after the intervention and analyzed using the intention-to-treat method. Results: The intervention (23 % male; mean age, 74.7 ± 4.7 years) and control (21 % male; mean age, 75.1 ± 4.1 years) groups did not differ significantly in baseline characteristics. Seventy-seven participants completed the program; two withdrew for personal reasons. The mean difference (standard error) between the groups for the primary outcome (usual walking speed) was 0.35 (0.04) m/s; the time-by-group interaction was significant (p < 0.001). Secondary outcomes (maximum walking speed, Timed Up and Go test results, 5-times chair-standing test results, and GLFS-5 scores) significantly improved in the intervention group. Body composition was unchanged in both groups. Conclusions: A 5-week exercise program using the HAL lumbar type is a promising option for community-dwelling older adults with limited mobility who do not require nursing care, resulting in clinically meaningful improvements in most physical functions within a short period.

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Goals and realities in local goverments' involvement in PA promotion for diverse populations subgroups - a comparative analysis of municipalities from 5 countries

Sandu, P., Gelius, P., Messing, S., Noel-Racine, A., Oguma, Y., Onatsu, T., Papiu, AP, Saito, Y., Takeda, N., Tuunanen, K., Vuillemin, A., Chereches, RM

EUROPEAN JOURNAL OF PUBLIC HEALTH (Oxford University Press (OUP)) 34 ( Supplement_2 ) 2024.09

ISSN 1101-1262

Abstract

Although cross-sectoral cooperation is important at all levels, in practice it often remains at a declarative level. Different sectoral policies and the resulting measures to promote HEPA are usually disconnected, uncoordinated and without the necessary synergies. This pertains especially to local environments with less financial and expert support, such as small rural communities, where people have few HEPA options that are suitable and attractive for vulnerable groups: children and adolescents, elderly and people with disabilities.

“Development of indicators for the assessment of the provision of settlements with green spaces for outdoor physical activity” is a research project co-funded by the Slovenian Research and Innovation Agency, the Ministry of Health and the Ministry of Natural Resources and Spatial Planning and implemented at the Urban Planning Institute of the Republic of Slovenia. The aim of the project is to define indicator(s) for the provision of green spaces for PA and active lifestyles in settlements, which could be used at local level to assess, improve, and monitor the situation. We took a medium-sized city and a small rural community as pilot projects, the latter often being a disadvantaged environment in terms of HEPA in spatial planning compared to larger cities. On the pilots, our objectives have been to establish cooperation at the local level between at least three different sectors and to test methodology and indicators developed in the project to assess the provision of green spaces to promote PA in selected environments, thus enabling more equitable and inclusive spatial conditions for HEPA at the local level.

The presentation will present the approach, results and overall experiences with the work implemented in the pilot project of a rural community. It will highlight the benefits of cross-sectoral cooperation for more effective local level HEPA policies to ensure the inclusive and equitable access to green spaces in settlements.

Funding source

Slovenian Research and Innovation Agency, grant no. V5-2232

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Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis

Okada, K., Ito, D., Morimoto, S., Kato, C., Oguma, Y., Warita, H., Suzuki, N., Aoki, M., Kuramoto, J., Kobayashi, R., Shinozaki, M., Ikawa, M., Nakahara, J., Takahashi, S., Nishimoto, Y., Shibata, S., Okano, H.

BRAIN 147 ( 11 ) 3933 - 3948 2024.09

ISSN 0006-8950

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Epidemiology of adverse events related to sports among community people: a scoping review

A Hirata, Y Saito, M Nakamura, Y Muramatsu, K Tabira, K Kikuchi, ...

BMJ open 14 (6), e082984 14 ( 6 ) e082984 2024.06

ISSN 2044-6055

Objectives Numerous reports have described injuries and illnesses in competitive athletes, but studies on leisure-time physical activity and associated adverse events in the general population have not been adequately reviewed. This study aimed to summarise the previous findings on this topic. Design Scoping review. Data sources PubMed and Ichushi-Web for articles in English and Japanese, respectively (13 April 2023). Eligibility criteria for selecting studies Articles on adverse events related to sports performed by € individuals and groups active in the community' were included, whereas those on elite athletes, exercise therapy and rehabilitation, and school sports were excluded. Terms related to physical activity, exercise, sports and adverse events were used for the search strategies. Results The literature search yielded 67 eligible articles. Most articles were from the USA, Japan and Australia. Running, scuba diving, rugby and soccer were the most commonly reported sports. Adults were the most common age category in the samples. The most commonly reported adverse events were injuries; only 10 articles reported diseases. 13 longitudinal studies reported the frequency of adverse events based on the number of events/participants×exposure. Conclusion Adverse events such as sports trauma, disability and certain diseases occur sometimes during sporting activities by residents; however, the articles identified in this review showed biases related to the countries and regions where they were published and the sports disciplines and types of adverse events reported, and articles reporting the frequency of adverse events were also limited. This highlights the need for more high-quality observational studies on diverse populations in the future.

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SEASONAL PATTERNS OF PHYSICAL ACTIVITY AND SEDENTARY BEHAVIOR AND INDOOR THERMAL ENVIRONMENT AMONG ADULTS LIVING IN SUBURBAN RESIDENTIAL AREA

ITO Maki, ANDO Shintaro, UMISHIO Wataru, OGUMA Yuko, SAITO Yoshinobu, IKAGA Toshiharu

Journal of Environmental Engineering (Transactions of AIJ) (Architectural Institute of Japan) 89 ( 820 ) 340 - 350 2024.06

ISSN 13480685

This study examined the seasonal patterns of physical activity (PA) and sedentary behavior (SB) and the relationship between PA and SB and the indoor thermal environment in each season. 98 of 131 the participants were analyzed.1) Daily moderate-to-vigorous PA was significantly greater in fall than in winter.2) Adjusting the accelerometer wearing time, outdoor PA and SB were not significantly related to season, but indoor moderate-to-vigorous PA were significantly greater in fall and summer than in winter.3) Using a kotatsu in winter was associated with longer SB and less light-intensity PA than using an air conditioner.

特集健康づくりのための身体活動・運動ガイド2023 【参考情報を読み解く】慢性疾患を有する人の身体活動のポイント

小熊祐子

臨床栄養 (医歯薬出版) 144 ( 5 ) 646 - 651 2024.05

ISSN 04851412

2．慢性有疾患者のガイドライン総論

小熊祐子

Japanese Journal of Clinical Sports Medicine (Japanese Society of Clinical Sports Medicine) 32 ( 2 ) 223 - 227 2024.04

ISSN 13464159

アクティブガイド改訂案

澤田亨, 小熊祐子

Japanese Journal of Clinical Sports Medicine (Japanese Society of Clinical Sports Medicine) 32 ( 2 ) 220 - 220 2024.04

ISSN 13464159

5．安全・安心に身体活動・運動を行うために

平田昂大, 小熊祐子, 黒瀬聖司, 齋藤義信, 佐藤真治, 都竹茂樹

Japanese Journal of Clinical Sports Medicine (Japanese Society of Clinical Sports Medicine) 32 ( 2 ) 228 - 231 2024.04

ISSN 13464159

Logic model and action plan for physical activitiy promotion: increasing step counts in daily life

INOUE Shigeru, KIKUCHI Hiroyuki, KAMADA Masamitsu, KITAYUGUCHI Jun, TSUZUKI Aoi, OGUMA Yuko

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 32 ( Special_issue ) S75 - S84 2024.04

ISSN 13402560

Objective: To present a logic model for increasing daily steps in the population and to categorize interventions using a ladder of interventions. Additionally, an example action plan is provided.Methods: Relevant policies and studies were reviewed, and 23 experts were interviewed. The logic model, based on the SLOTH model (Sleep, Leisure, Occupation, Transportation, Household), categorized daily life domains and considered steps during work, transportation, and at home & in the community as intermediate outcomes. Individual interventions were categorized using a ladder of interventions. An example action plan introduced multi-strategic community-wide interventions with evidence of success in promoting physical activity at the community level.Results: The logic model outlined individual interventions categorized by implementing entities (government, workplaces, health insurance associations, schools, related organizations). By envisioning domains of walking, specific measures emerged to increase step counts. The proposed individual interventions included not only information provision and health education but also interventions corresponding to levels 1-6 of the ladder of interventions. Multi-strategic community-wide intervention is an intervention that works on multiple levels of factors from individual to environment in a multifaceted manner, indicating the need for collaboration with various organizations and residents on a long-term basis from the perspective of the target population.Conclusion: Efforts should be directed not only within the health and welfare sector but also across various sectors such as education, sports, urban planning, and urban transportation. Strategies tailored to specific domains of daily life and from the perspective of residents should be considered, and a long-term, systematic approach is needed.

地域在住高齢者における冬季の室温と年間の住宅内の転倒の関連スマートウェルネス全国調査による横断研究

伊藤真紀, 伊香賀俊治, 小熊祐子, 齋藤義信, 藤野善久, 安藤真太朗, 村上周三

日本老年医学会雑誌 ((一社)日本老年医学会) 61 ( 2 ) 218 - 227 2024.04

ISSN 0300-9173

目的:高齢者の転倒予防は公衆衛生上の重要な課題である.高齢者の転倒は冬季に増加し,約半数が屋内で発生するなどの報告もあるため,本研究は地域在住高齢者における冬季の室温と住宅内の年間の転倒の関連を検討することを目的とした.方法:本研究は地域在住高齢者を対象とした横断研究である.全国の住宅事業者を通して対象者を募集し,964名が参加した.冬季2週間の居間床近傍室温を測定し,覚醒在宅時間帯の平均値から,寒冷群(12℃未満),準寒冷群(12℃以上18℃未満),温暖群(18℃以上)に分類した.過去1年間の転倒経験(つまずき含む)は自記式質問票から把握した.冬季の室温と住宅内の年間の転倒の関連を,ロジスティック回帰分析を用いて検討した.目的変数は年1回以上の転倒有無,説明変数は覚醒在宅時間帯の平均居間床近傍室温とし,年齢,性別,BMI,世帯年収,心身の健康状態,身体活動,住宅環境,地域などを共変量とした.また,年2回以上の転倒有無を目的変数とした副次解析も実施した.結果:転倒と室温に欠損のない907名(平均年齢72.0±6.3歳)を解析対象とした.寒冷群は265名,準寒冷群は553名,温暖群は89名であった.年1回以上の転倒経験者は325名(35.8%)で,そのうち148名(16.3%)が年2回以上の転倒経験者であった.多変量解析の結果,温暖群は寒冷群に比べて年1回以上の転倒のオッズ比は0.49(95%信頼区間:0.26～0.94)と有意に低く,年2回以上の転倒のオッズ比も0.34(95%信頼区間:0.12～0.93)と有意に低かった.結論:冬季の居間の床近傍室温が高い住宅に居住する高齢者は,住宅内で1年間に転倒するオッズ比が有意に低かった.住宅内で長時間を過ごす高齢者にとって,冬季に良好な温熱環境を保つことは,住宅内の転倒予防に寄与する可能性がある.(著者抄録)

Digital Peer-Supported App Intervention to Promote Physical Activity Among Community-Dwelling Older Adults: Nonrandomized Controlled Trial (Preprint)

2024.01

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Association of polydoctoring and mortality among persons over 85 years with multimorbidity: a prospective cohort study in Japan

T Ando, T Sasaki, Y Abe, Y Nishimoto, T Hirata, T Tajima, Y Oguma, ...

BJGP open 8 (3) 2024

An approach for the analysis of axonal neuroinflammation by measuring dual biomarkers of oligodendrocytes and inflammatory cytokine in human plasma

M Mitsuhashi, A Hirata, Y Oguma, H Ishida, K Kawata

Research Square 2024

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Sponsored Symposium3-3

小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 73 ( 1 ) 8 - 8 2024

ISSN 0039906X

Symposium4

井上茂, 小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 73 ( 1 ) 26 - 26 2024

ISSN 0039906X

Symposium2

佐藤真治, 小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 73 ( 1 ) 18 - 18 2024

ISSN 0039906X

Symposium2-1

平田昂大, 小熊祐子, 黒瀬聖司, 齋藤義信, 佐藤真治, 都竹茂樹

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 73 ( 1 ) 19 - 19 2024

ISSN 0039906X

Association of polydoctoring and mortality among very old persons with multimorbidity: a prospective cohort study in Japan

T Ando, T Sasaki, Y Abe, Y Nishimoto, T Hirata, T Tajima, Y Oguma, ...

BJGP open 8 ( 3 ) 2024

Background: Polydoctoring can increase the risk of care fragmentation among patients with multimorbidity, but its impact on health outcomes remains unclear. Aim: To determine the effects of polydoctoring, as measured by the regularly visited facilities (RVF) indicator, on patient outcomes among older individuals with multimorbidity. Design & setting: Data from the ongoing prospective cohort study, Kawasaki Aging and Wellbeing Project (KAWP), was utilised in this study. Among the 1026 KAWP participants aged 85–89 years, those with two or more chronic conditions were enrolled in this study. Method: Care fragmentation and polydoctoring was evaluated using the RVF, which is a new indicator that measures the number of medical facilities consistently involved in a patient’s care. Based on RVF, mortality was analysed using the Cox proportional hazards model, with adjustments for age, sex, frailty, and number of comorbidities. Results: A significant reduction in mortality rates was observed in participants with an RVF of ≥3 and 2–4 comorbidities (hazard ratio [HR] 0.43, 95% confidence interval [CI] = 0.18 to 0.99, P value = 0.048). However, no significant difference in mortality based on RVF was observed for those with ≥5 comorbidities. Notably, individuals with ≥5 comorbidities and an RVF of 0 had a significantly higher HR for death (HR 2.68, 95% CI = 1.05 to 6.84, P value = 0.039). Conclusion: In older patients with multimorbidity, polydoctoring may reduce mortality in patients with ≤4 coexisting conditions, but it does not significantly impact mortality in those with ≥5 conditions. These findings provide insights for healthcare decision making in managing older patients with multimorbidity.

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Assessment of adverse events and near misses during voluntary community-driven sports activities by community residents: a cross-sectional study

A Hirata, Y Oguma, T Hashimoto

The Journal of Physical Fitness and Sports Medicine 13 (1), 19-31 (The Japanese Society of Physical Fitness and Sports Medicine) 13 ( 1 ) 19 - 31 2024

ISSN 21868131

Although physical activities have many health benefits, adverse events and near misses, such as injuries and falls, can occur during these activities. This study aimed to assess the occurrence of adverse events and near misses during sports activities conducted independently by community residents. A survey questionnaire was sent via the internet to the leaders or directors of sports organizations at six public sports centers or associations. In total, 108 individuals answered the survey, with 60% male and 40% female respondents. Individuals aged 50–69 years accounted for 60% of the total number of respondents. All respondents were asked about their experiences of adverse events and near misses within the past three years: the reports of these incidents were obtained using the recall method. Duplicate adverse events and near misses were identified based on the sports discipline, time of occurrence, and sex and age of person involved to determine if there were duplicate reports. Most of the respondents’ activities as staff were performed once a month, with each activity lasting 1–2 h. Forty-five adverse events were reported, including 26 injuries, 13 falls, and 6 others (such as heat stroke, vertigo, and presyncope). Twenty-four near misses were reported, including 12 near collisions with people or objects, five near falls, and seven other incidents. We found that approximately 30% of the respondents experienced adverse events, suggesting the need for documentation of adverse events, implementation of safety measures, and proper safety education for operating staff.

慶應義塾大学体育会に所属する女子部員の月経状況とセルフケアに関する研究

奥山靜代, 東原綾子, 清水花菜, 板垣悦子, 佐々木玲子, 小熊祐子

体育研究所紀要 (慶應義塾大学体育研究所) 63 ( 1 ) 13 - 21 2024

ISSN 0286-6951

慶應義塾大学体育会に所属する女子部員を対象に、月経および月経随伴症状(PMS)等の実態やセルフケア等についてWebを用いての質問紙調査を実施した。調査期間は2022年11月から12月であった。121名(平均年齢19.9±1.1歳、平均身長160.8±5.3cm、平均体重53.1±5.7kg)から回答を得た。月経周期が25～38日の正常な対象者は98名、24日以下あるいは39日以上の月経周期異常の学生は19名、3ヵ月以上月経がない、いわゆる無月経と回答した学生は3名であった。月経の程度について、勉強・運動・仕事に支障があるかについて「支障はない」36名、「少し支障がある」54名、「横になって休憩する必要がある」20名、「1日以上寝込む」1名、「月経痛がまったくない」10名、との回答であった。62%の対象者が月経前の症状により競技パフォーマンスに障害を感じていると回答した。女子部員の約7割はPMS/PMDDに対策を全くしていないことが示された。

The relationship between dietary pattern and physical activity combinations to physical performance in 85+ Japanese population: A cross-sectional study from the TOOTH study

T Yu, Y Oguma, K Asakura, M Takayama, Y Abe, Y Arai

Archives of Gerontology and Geriatrics Plus 1 (3), 100038 2024

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S08-3: Goals and realities in local goverments’ involvement in PA promotion for diverse populations subgroups–a comparative analysis of municipalities from 5 countries

P Sandu, P Gelius, S Messing, A Noel-Racine, Y Oguma, T Onatsu, ...

European Journal of Public Health 34 (Supplement_2), ckae114. 234 2024

Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study

T Tajima, Y Oguma, Y Saito, Y Abe, IM Lee, Y Arai

The Journal of Frailty & Aging 13 (4), 413-420 2024

Digital Peer-Supported App Intervention to Promote Physical Activity Among Community-Dwelling Older Adults: Nonrandomized Controlled Trial

K Tabira, Y Oguma, S Yoshihara, M Shibuya, M Nakamura, N Doihara, ...

JMIR aging 7, e56184 7 e56184 2024

Background: The use of mobile apps has promoted physical activity levels. Recently, with an increasing number of older adults accessing the internet, app-based interventions may be feasible in older populations. Peer support-based interventions have become a common method for promoting health-related behavior change. To our knowledge, the feasibility of using digital peer support apps (DPSAs) to increase physical activity among older adults and its impact on physical activity and physical function have not been investigated. Objective: This study aims to assess the feasibility of using DPSAs in older adults and to assess changes in physical activity and physical function in DPSA users. Methods: We conducted a nonrandomized controlled trial of older adults aged ≥65 years. We recruited participants for 2 distinct 12-week programs designed to increase physical activity. Participants could choose between an intervention group (app program and exercise instruction) or a control group (exercise instruction only). DPSA creates a group chat for up to 5 people with a common goal, and participants anonymously post to each other in the group. Once a day, participants posted a set of their step counts, photos, and comments on a group chat box. The intervention group used the DPSA after receiving 2 face-to-face lectures on its use. The participants were characterized using questionnaires, accelerometers, and physical function assessments. The feasibility of the DPSA was assessed using retention and adherence rates. Physical activity was assessed using accelerometers to measure the daily step count, light intensity physical activity, moderate to vigorous intensity physical activity (MVPA), and sedentary behavior. Physical function was assessed using grip strength and the 30-second chair-stand test. Results: The participants in the intervention group were more frequent users of apps, were more familiar with information and communication technology, and had a higher baseline physical activity level. The retention and adherence rates for the DPSA intervention were 88% (36/41) and 87.7%, respectively, indicating good feasibility. Participants in the intervention group increased their step count by at least 1000 steps and their MVPA by at least 10 minutes using the DPSA. There was a significant difference in the interaction between groups and intervention time points in the daily step count and MVPA (step count, P=.04; duration of MVPA, P=.02). The DPSA increased physical activity, especially in older adults with low baseline physical activity levels. Conclusions: The feasibility of DPSA was found to be good, with the intervention group showing increases in daily steps and MVPA. The effects of DPSA on step count, physical activity, and physical function in older adults with low baseline physical activity should be investigated using randomized controlled trials.

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Association between indoor temperature during winter and falls at home in the past year among community-dwelling older adults: a cross-sectional analysis of the nationwide …

M Ito, T Ikaga, Y Oguma, Y Saito, Y Fujino, S Ando, S Murakami

Nippon Ronen Igakkai Zasshi 61 (2), 218-227 2024

Association between indoor temperature during winter and falls at home in the past year among community-dwelling older adults: A cross-sectional analysis of the nationwide Smart Wellness Housing survey in Japan

Ito Maki, Ikaga Toshiharu, Oguma Yuko, Saito Yoshinobu, Fujino Yoshihisa, Ando Shintaro, Murakami Shuzo, on behalf of the SWH survey group

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (The Japan Geriatrics Society) 61 ( 2 ) 218 - 227 2024

ISSN 03009173

Aim: Some studies have reported a higher incidence of falls during winter with similar proportions of indoor and outdoor falls. We investigated the relationship between indoor temperature during winter and falls at home in the past year among community-dwelling older adults.Methods: This cross-sectional study enrolled 964 individuals of ≥65 years of age in Japan. Participants answered questions about falls (including trips) at home within the past year, and the living room temperature was measured for 2 weeks during winter. Participants were divided into those living in cold (mean temperature near the floor <12°C), slightly cold (12-17.9°C), and warm (≥18°C) houses. The association between indoor temperature (cold vs. slightly cold vs. warm houses) and falls at home in the past year was examined using a logistic regression analysis adjusted for potential confounding factors.Results: Valid data were obtained from 907 participants (mean age: 72.0±6.3 years), of whom 265,553, and 89 lived in cold, slightly cold, and warm houses, respectively. In the past year, falls occurred once in 325 (35.8%) participants and multiple times in 148 (16.3%) participants. In warm houses, the odds ratio of falling once and multiple times in the past year was 0.49 (p=0.032) and 0.34 (p=0.035), respectively, in comparison to cold houses.Conclusions: Living in cold houses may be associated with an increased risk of falling at home among older adults. Maintaining an appropriate indoor thermal environment during winter may reduce the risk of falling among individuals who spend most of their time at home.

Does health literacy moderate the psychological pathways of physical activity from guideline awareness to behavior? A multi-group structural equation modeling

T Tajima, K Harada, Y Oguma, SS Sawada

BMC Public Health 23 (1), 1-13 (BMC Public Health) 23 ( 1 ) 106 2023.12

Research paper (scientific journal), Joint Work, Accepted

Background: Awareness, knowledge, beliefs, and behavioral intentions of physical activity (PA) guidelines may be important mediating factors for promoting PA. However, these pathways of the psychological process to PA behavior have not been examined. These pathways may differ depending on health literacy levels. This study investigated the pathways to PA, from guideline awareness to behavior, and further examined whether they differed by health literacy. Methods: A cross-sectional study was conducted with 7,000 Japanese participants aged 20–69 years. The participants were registered with an Internet survey company. Participants’ awareness, knowledge, beliefs, and behavioral intentions regarding the PA guidelines of Japan, the volume of moderate-to-vigorous intensity PA, activity level, and health literacy were examined through a questionnaire. The PA pathways, from guideline awareness to behavior, were examined by structural equation modeling (SEM), with PA behavior as the dependent variable. Multi-group SEM was conducted to examine the moderating effect of health literacy on PA pathways. Health literacy scores were dichotomized into high and low groups in multi-group modeling by the median split. Results: SEM revealed that PA guideline awareness directly affects PA behavior and has certain indirect effects through the mediation of knowledge, beliefs, and behavioral intentions. Furthermore, the multi-group SEM showed that the proportion of indirect effects (path coefficient [PC]: 0.11, 95% confidence interval [CI]: 0.10–0.13) was higher than direct effects (PC: 0.07, 95%CI: 0.03–0.11) in the high-health literacy group. In contrast, the proportion of direct effects (PC: 0.22, 95%CI: 0.15–0.30) was higher than indirect effects (PC: 0.06, 95%CI: 0.05–0.07) in the low-health literacy group. Conclusions: PA guideline awareness is both directly and indirectly associated with PA behavior, mediated by psychological pathways of knowledge, beliefs, and behavioral intentions, and influenced by health literacy. These results suggest that health literacy should be considered when implementing PA guideline-based interventions.

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Characteristics Of Training Room Users And Adverse Events At A Community Healthcare Center

Hirata, A; Oguma, Y; Tanaka, A; Ogawa, Y; Himeno, H; Saito, Y; Sato, S; Tsuzuku, S; Kurose, S

MEDICINE & SCIENCE IN SPORTS & EXERCISE 55 ( 9 ) 1015 - 1017 2023.09

ISSN 0195-9131

The Joint Association Of Physical Activity And Sedentary Behavior With Cardiorespiratory Fitness In Middle-aged Japanese: KZS Study

Zhai, XY; Sawada, SS; Kurosawa, S; Koriyama, S; Dimitroff, SA; Moniwa, Y; Oka, K; Oguma, Y; Sato, S; Maruo, K; Nakata, Y; Miyachi, M; Gando, Y; Lee, IM; Sui, XM

MEDICINE & SCIENCE IN SPORTS & EXERCISE 55 ( 9 ) 454 - 454 2023.09

ISSN 0195-9131

Relationship between dietary patterns with subjectively measured physical activity in 85+years older

Yu, T, Oguma, Y, Asakura, K, Abe, Y, Arai, Y

ANNALS OF NUTRITION AND METABOLISM 79 896 - 896 2023.08

ISSN 0250-6807

Plasma amino acid signature for sarcopenic phenotypes in community-dwelling octogenarians: Results from the Kawasaki Aging Wellbeing Project

Y Osawa, J Candia, Y Abe, T Tajima, Y Oguma, Y Arai

Experimental Gerontology 178, 112230 (Experimental Gerontology) 178 112230 2023.07

Research paper (scientific journal), Accepted, ISSN 05315565

Sarcopenia is one of the primary risk factors for various adverse health events in later life. However, its pathophysiology in the very old population remains unclear. Hence, this study aimed to examine whether plasma free amino acids (PFAAs) correlate with major sarcopenic phenotypes (i.e., muscle mass, muscle strength, and physical performance) in community-dwelling adults aged 85–89 years living in Japan. Cross-sectional data from the Kawasaki Aging Well-being Project were used. We included 133 adults aged 85–89 years. In this study, fasting blood was collected to measure 20 plasma PFAAs. Measures for the three major sarcopenic phenotypes included appendicular lean mass assessed by multifrequency bioimpedance, isometric handgrip strength, and gait speed from a 5 m walk at a usual pace. Furthermore, we used phenotype–specific elastic net regression models adjusted for age centered at 85 years, sex, body mass index, education level, smoking status, and drinking habit to identify significant PFAAs for each sarcopenic phenotype. Higher histidine and lower alanine levels were associated with poor gait speed, but no PFAAs correlated with muscle strength or mass. In conclusion, PFAAs such as plasma histidine and alanine are novel blood biomarkers associated with physical performance in community-dwelling adults aged 85 years or older.

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加速度計で調査した85-89歳地域在住高齢者の座位行動と関連要因の横断的検討　The Kawasaki Aging and Wellbeing Project

新村直子, 田島敬之, 齋藤義信, 於タオ, 吉田奈都子, 阿部由紀子, 新井康通, 小熊祐子

運動疫学研究: Research in Exercise Epidemiology (日本運動疫学会) 25 ( 1 ) 19 - 30 2023.06

ISSN 1347-5827

目的:85-89歳の地域在住高齢者の座位行動を客観的に評価し,テレビ視聴時間を含む関連要因について多面的に検討する。方法:The Kawasaki Aging and Wellbeing Project(KAWP)のベースライン(2017-18年)調査の参加者1,026名に連続7日間の加速度計装着を依頼し,有効データ914名(女性473名)の座位行動を客観的に評価した。重回帰分析を男女別に行い,座位行動との関連要因を3領域(身体状況,社会経済状況,生活習慣)の24因子と年齢,計25因子から検討した。結果:総座位時間・装着時間に占める座位時間の割合は男性1日平均(標準偏差)9.4(1.9)時間・67%,女性8.6(1.8)時間・59%と男性が女性より長く座っており,30分以上継続する座位時間の割合も女性より高かった。重回帰分析により座位行動と関連が認められた要因は,関連が強い順に,男性ではテレビ視聴時間・BMI(正),家事時間・園芸スコア・運動時間・歩行速度・握力・ADL(負),女性ではBMI・テレビ視聴時間(正),家事時間・睡眠時間・運動時間・ADL・外出スコア(負)であった。結論:80歳代後半の地域在住高齢者の座位行動にはテレビ視聴以外に,BMI・歩行速度・握力・ADLなどの身体状況要因,家事・園芸・運動・睡眠・外出などの生活習慣要因が多面的に関連していた。(著者抄録)

断熱改修が成人における冬季の住宅内座位行動および身体活動に及ぼす影響　スマートウェルネス住宅調査による準実験的研究

伊藤真紀, 伊香賀俊治, 小熊祐子, 齋藤義信, 藤野善久, 安藤真太朗, 村上周三

運動疫学研究: Research in Exercise Epidemiology (日本運動疫学会) 25 ( 1 ) 50 - 63 2023.06

ISSN 1347-5827

目的:断熱改修が冬季の住宅内の座位行動と身体活動に及ぼす影響を検討した。方法:断熱改修に意欲的な成人を募集し,冬季2週間のベースライン調査(改修前)と,その1～4年後の同時期に追跡調査(改修後)を行った。住宅内の座位時間と低強度以上の身体活動量(light-to-vigorous physical activity;LVPA)は,加速度計と外出記録から評価した。断熱改修を行った介入群と断念した対照群に対象者を分け,住宅内の座位時間とLVPAの変化との関連を線形混合モデルで検討した。また,脱衣所室温変化量[低下(-1℃未満),変化なし(-1℃以上+1℃未満),上昇小(+1℃以上+5℃未満),上昇大(+5℃以上)]を説明変数に加えた解析も実施した。結果:1,751名(介入群1,640名,対照群111名)を解析対象とした。脱衣所室温は介入群で有意に上昇したが,群間で調査期間のずれが生じたことなどにより,対照群の室温も外気温の上昇に伴い上昇していた。多変量解析の結果,断熱改修と住宅内の座位時間・LVPAの変化に有意な関連は認められなかった。ただし,脱衣所室温変化量は有意に関連していた。室温が変化しなかった場合に比べて,5℃以上改善した場合は,座位時間が減少し,LVPAは増加したが,室温が低下した場合には,座位時間が増加し,LVPAは減少した。結論:断熱改修は住宅内の座位時間とLVPAの変化に関連していなかった。ただし,脱衣所等の室温改善は,住宅内の座位行動を抑制し,LVPAを増加させる可能性が示唆された。今後も検証が必要である。(著者抄録)

地域住民の自主的な運動・スポーツ中における有害事象の調査　横浜市栄区セーフコミュニティ推進協議会スポーツ安全対策分科会による質問紙調査から

平田昂大, 小熊祐子, 真鍋知宏, 橋本健史

運動疫学研究: Research in Exercise Epidemiology (日本運動疫学会) 25 ( 1 ) 7 - 18 2023.06

ISSN 1347-5827

目的:栄区セーフコミュニティの活動の一環として実施されたアンケート調査から,栄区民が自主的に実施している運動・スポーツ中における有害事象(事故・けが)の現状と傾向を捉えることを目的とした。方法:2017年に栄区が自主的に運動・スポーツを実施している者を対象に実施した「スポーツ活動時に発生した事故・けがに関するアンケート(選択式・自由記述)」から得られたデータを量的・質的に解析を行った混合研究である。回答が得られた518件のうち,解析が可能であった473件を解析対象として実施した。結果:過去5年間の活動で有害事象があったのは94件(20%)であった。サッカー,バドミントン,バレーボールの順に報告数が多く,下肢の捻挫・靱帯損傷(26件),下肢の筋・腱損傷(20件),頭部・顔面の打撲(7件)が多く発生していた。自由記述の結果からアキレス腱断裂,膝関節前十字靱帯損傷,頭蓋骨骨折,大腿骨骨折,脳出血が発生していた。年代別では,40～50代の筋・腱損傷(16件),60～70代の転倒(11件)が特徴的であった。結論:地域住民が自主的に実施している運動・スポーツ中において、足関節捻挫などの下肢の傷害や高齢者の転倒といった有害事象が発生していることが明らかとなった。これらに対する予防策,対策を講じる必要性が示唆された。(著者抄録)

D-42 Cardiometabolic Disease/Obesity

X Zhai, SS Sawada, S Kurosawa, S Koriyama, SA Dimitroff, Y Moniwa, ...

2023

Epidemiology of adverse events and near misses in public exercise facilities: A prospective cohort study

A Hirata, Y Oguma, Y Saito, T Ito, K Kondo, Y Takemoto, T Nishigaya, ...

2023

Research paper (scientific journal), Corresponding author, Accepted

Questionnaire-assessed physical activity among Japanese adults: The J-MICC Study

Saito Yoshinobu, Oguma Yuko, Nakamura Sho, Narimatsu Hiroto, Nakashima Ryoko, Ikezaki Hiroaki, Tanaka Keitaro, Hara Megumi, Tamada Yudai, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Oze Isao, Taniyama Yukari, Mikami Haruo, Nagase Hiroki, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Otani Takahiro, Koyama Teruhide, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Takashima Naoyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Takeuchi Kenji, Wakai Kenji, J-MICC Study Group

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 112 - 113 2023

Research paper (scientific journal), Joint Work, Accepted, ISSN 13475827

Relationship between dietary patterns and physical performance in the very old population: A cross-sectional study from the Kawasaki Aging and Wellbeing Project

T Yu, Y Oguma, K Asakura, Y Abe, Y Arai

Public Health Nutrition, 1-18 (Public Health Nutrition) 26 ( 6 ) 1 - 18 2023

Research paper (scientific journal), Joint Work, Corresponding author, Accepted, ISSN 1368-9800

Objectives: As the world's population is ageing, improving the physical performance of the older population is becoming important. Although diets are fundamental to maintaining and improving physical performance, few studies have addressed the role of these factors in adults aged ≥85 years, and none have been conducted in Asia. This study aimed to determine the dietary patterns and examine their relationship with physical performance in this population. Design: This cross-sectional study (Kawasaki Aging and Wellbeing Project) estimated food consumption using a brief-type self-administered diet history questionnaire. The results were adjusted for energy after aggregating into 33 groups, excluding possible over- or underestimation. Principal component analysis was used to identify dietary patterns, and outcomes included hand grip strength, timed up-and-go test, and usual walking speed. Setting: This study was set throughout several hospitals in Kawasaki city. Participants: In total, 1,026 community-dwelling older adults (85-89 years) were enrolled. Results: Data of 1,000 participants (median age: 86.9 years, men: 49.9 %) were included in the analysis. Three major dietary patterns (DP1: various foods, DP2: red meats and coffee, DP3: bread and processed meats) were identified. The results of multiple regression analysis showed that the score of DP2 was negatively associated with hand grip strength (B, 95% confidence interval: -0.35, -0.64 to -0.06). Conclusions: This study suggests a negative association between hand grip strength and dietary patterns characterised by red meats and coffee in older adults aged ≥85 years in Japan.

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Symposium22　COVID-19パンデミックの身体活動・運動への影響

町田征己, 小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 72 ( 1 ) 96 - 96 2023

Research paper (other academic), ISSN 0039906X

Symposium1-6慢性疾患を有する人のためのアクティブガイド・ファクトシート・インフォメーションシートについて

小熊祐子, 加賀英義, 齋藤義信, 佐藤真治, 田島敬之, 田村好史, 津下一代, 原藤健吾, 宮下政司, 横山美帆

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 72 ( 1 ) 17 - 17 2023

ISSN 0039906X

Accelerometer-assessed physical activity of junior high schoolers in Tokyo, Hiroshima, and Kochi

Baba Akiko, Ikaga Toshiharu, Oguma Yuko, Ito Maki

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 128 - 129 2023

ISSN 13475827

Accelerometer-assessed physical activity among community-dwelling older Japanese adults: Smart Wellness Housing Survey

Yoshizawa Yasuyo, Oguma Yuko, Doihara Natsue, Saito Yoshinobu, Tajima Takayuki, Ito Maki, Ikaga Toshiharu

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 130 - 131 2023

ISSN 13475827

Accelerometer-assessed physical activity of elementary schoolers in Kawasaki city

Baba Akiko, Ikaga Toshiharu, Oguma Yuko, Ito Maki, Kaneko Masashi

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 126 - 127 2023

ISSN 13475827

Adverse events during community residents' independent physical activity and sports: a questionnaire survey conducted by Safe Community Sports Safety Subcommittee in Sakae ward Yokohama city

Hirata Akihiro, Oguma Yuko, Manabe Tomohiro, Hashimoto Takeshi

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 7 - 18 2023

Accepted, ISSN 13475827

Objective: This study aimed to determine trends in adverse events during voluntary physical activity and sports performed by Sakae Ward residents.
 Methods: This mixed study quantitatively and qualitatively analyzed the data obtained from a questionnaire (selective and free text) regarding accidents and injuries during sports activities conducted by Sakae Ward in 2017 for people who voluntarily engaged in sports activities. Of the 518 responses, 473 were included in the analysis.
 Results: There were 94 cases (20%) with adverse events in the last 5 years. Soccer, badminton, and volleyball, in that order, had the most frequently reported adverse events. Sprain/ligament injuries of the lower extremities (26 cases), muscle/tendon injuries of the lower extremities (20 cases), and contusions of the head/face (7 cases) were the most common injuries. The results of free descriptions also confirmed the occurrence of serious injuries such as Achilles tendon rupture, anterior cruciate ligament injury of the knee joint, skull fracture, femur fracture, and cerebral hemorrhage. Muscle and tendon injuries (16 cases) were distinctive among residents in the 50–60 age group, while falls (11 cases) was distinctive in the 60–70 age group.
 Conclusion: The study results show that lower limb injuries such as sprained ankle joints and adverse events such as falls among the elderly occurred during physical activity and sports voluntarily performed by Sakae Ward residents. Therefore, preventive measures and countermeasures should be taken to prevent these adverse events.

Effect of insulation retrofitting on sedentary behavior and physical activity at home among adults in winter: a quasi-experimental study of the Nationwide Smart Wellness Housing Survey in Japan

Ito Maki, Ikaga Toshiharu, Oguma Yuko, Saito Yoshinobu, Fujino Yoshihisa, Ando Shintaro, Murakami Shuzo, the Smart Wellness Housing Survey group

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 50 - 63 2023

Research paper (scientific journal), Joint Work, Accepted, ISSN 13475827

Objective: We aimed to examine the effects of insulation retrofitting on sedentary behavior time (SBT) and light-to-vigorous physical activity (LVPA) at home in adults during winter.
 Methods: Adults intending to retrofit their insulation participated in a 14-day baseline survey in winter and a follow-up survey 1–4 years after retrofitting. Participants were classified into an intervention (insulation retrofitting) or a control (non-insulation retrofitting) group. SBT and LVPA changes were calculated using an accelerometer and questionnaires. A multilevel model was fitted to estimate the effects of insulation retrofitting on these changes. As a secondary analysis, the change in dressing room temperature (Td) from baseline was added as an independent variable in the model, categorized as a decrease in Td (<-1.0°C), no change in Td (-1.0°C to +0.9°C), a small increase in Td (+1.0°C to +4.9°C), and a large increase in Td (≥+5.0°C).
 Results: Of the 1751 participants, 1640 were in the intervention group. Both groups experienced an increase in Td. The intervention group experienced a slight increase in outside temperature, whereas the control group experienced a significant increase in outside temperature. Insulation retrofitting was not significantly associated with SBT and LVPA at home; however, the change in Td was significantly associated with SBT and LVPA. Compared to no change in Td, the large increase in Td was associated with a decrease in SBT and an increase in LVPA. In contrast, the decrease in Td was associated with an increase in SBT and a decrease in LVPA.
 Conclusion: Insulation retrofitting was not associated with changes in SBT and LVPA in adults during winter. However, improving room temperature, including Td, could potentially decrease SBT and increase LVPA in adults. Further research is needed to confirm the effect of insulation retrofitting on SBT and LVPA.

Accelerometer-assessed sedentary behavior and its correlates among 85–89-year-old community-dwelling older adults: a cross-sectional study by The Kawasaki Aging and Wellbeing Project

Shinmura Naoko, Tajima Takayuki, Saito Yoshinobu, Yu Tao, Yoshida Natsuko, Abe Yukiko, Arai Yasumichi, Oguma Yuko

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) advpub ( 0 ) 19 - 30 2023

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted, ISSN 13475827

Objective: The purpose of this cross-sectional study was to evaluate the sedentary behavior of community-dwelling older adults aged 85–89 years using an accelerometer, and to investigate its correlates, including TV viewing time, from a multifaceted perspective.
 Methods: We asked 1,026 participants in the 2017–2018 baseline survey of “The Kawasaki Aging and Wellbeing Project” to wear an accelerometer for 7 consecutive days. Of these, we evaluated sedentary behavior of valid data from 914 people (473 women). Using multiple regression analysis by gender, we investigated the correlation of 25 factors with sedentary behavior ─24 factors in 3 domains (physical condition, socio-economic condition, and lifestyle) and age.
 Results: The average (SD) total sedentary time and the proportion of sedentary time to wearing time of men and women were 9.4 (1.9) hours/67% per day and 8.6 (1.8) hours/59% per day, respectively. Moreover, men’s proportion of prolonged sedentary time (≥ 30 minutes) was higher than that of women. For men, the following factors were correlated with sedentary behavior in order of strength of association: screen time and BMI (positive); household work time, gardening score, exercise time, walking speed, grip strength, and ADL (negative). For women, the correlated factors were BMI and screen time (positive); household work time, sleep time, exercise time, ADL, and outing score (negative).
 Conclusion: The sedentary behavior of community-dwelling older adults in their late 80s was correlated not only to screen time but also to physical condition factors (such as BMI, walking speed, grip strength, and ADL), and lifestyle factors (such as household work, gardening, exercise, sleep, and going out).

The Joint Association Of Physical Activity And Sedentary Behavior With Cardiorespiratory Fitness In Middle-aged Japanese: KZS Study: 1363

X Zhai, SS Sawada, S Kurosawa, S Koriyama, SA Dimitroff, Y Moniwa, ...

Medicine & Science in Sports & Exercise 55 (9S), 454 2023

Research paper (scientific journal), Joint Work, Accepted

Characteristics Of Training Room Users And Adverse Events At A Community Healthcare Center: 3029

A Hirata, Y Oguma, A Tanaka, Y Ogawa, H Himeno, Y Saito, S Sato, ...

Medicine & Science in Sports & Exercise 55 (9S), 1015-1017 2023

Research paper (international conference proceedings), Corresponding author, Accepted

Association between physical activity patterns and quality of life in Japanese adults aged 85 to 89 years: a cross-sectional study

Y Muramatsu, Y Oguma, Y Abe, A Hara, H Urushihara, Y Arai

2023

Accelerometer-assessed physical activity among community-dwelling older Japanese adults: Fujisawa Plus 10 Project

Ito Tomoya, Nakamura Manabu, Tajima Takayuki, Saito Yoshinobu, Oguma Yuko

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) 24 ( 2 ) 110 - 111 2022.12

ISSN 13475827

A comparison of physical characteristics in starters and non-starters in a Japanese university rugby football players

Hirata Akihiro, Nakajima Tetsuya, Iwamoto Sayumi, Oguma Yuko, Kotake Naohiko

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 71 ( 6 ) 523 - 530 2022.12

ISSN 0039906X

The purpose of this study was to compare the characteristics of starters and non-starters with respect to the anthropometric and physical fitness in a Japanese university rugby team. Our sample pool consisted of 54 players of the K University rugby team, who were registered for the official games (all 7 games/year) in 2018 and 2019. The starter group (26 players) comprised of players with more than 3 games/year while the non-starter group (28 players) comprised of players that registered for official games but played less than 3 games. Anthropometric parameters, such as height, body mass, skinfold (8 items), girth (5 items), body composition, muscular strength, intermittent endurance, and sprint time, were assessed. We found that the starter group for forwards had lower skinfold (Biceps, Iliac crest, Supraspinale, Abdominal, Front thigh, and Medial calf) and percentage body fat than in the non-starter group. The starter group for backs had muscle strength of narrow chinning is higher than in the non-starter group. Finally, our study helped to clarify the physical factors that influence the difference in athletic performance between starters and non-starters in university rugby team. The forward starters had lower percentage body fat and better body composition and backs starters had better narrow chinning. The findings provide information to university rugby players who want to become starters, as well as help the coaching staff understand the factors that need to be strengthened in the players.

Inter-rater reliability of streetscape audits using online observations: Microscale Audit of Pedestrian Streetscapes (MAPS) Global in Japan

Saito Y., Oguma Y., Inoue S., Breugelmans R., Kikuchi H., Oka K., Okada S., Takeda N., Cain K.L., Sallis J.F.

Preventive Medicine Reports, 102043 (Preventive Medicine Reports) 30 102043 2022.12

Research paper (scientific journal), Joint Work, Accepted, ISSN 2211-3355

This study aimed to evaluate the inter-rater reliability of streetscape audits among online observations using the Microscale Audit of Pedestrian Streetscapes-Global version (MAPS-Global) in Japan. MAPS-Global observations were conducted on routes with distances ranging from 400 to 725 m from a residence toward a non-residential destination. Google Street View audits were independently conducted by two trained raters on each route. A tiered scoring system was applied to summarize the items at multiple levels of aggregation. Positive and negative valence scores were created based on the expected association with physical activity. Inter-rater reliability analyses were performed using kappa statistics or intraclass correlation coefficients (ICC). Of the 32 older adults participating in an intervention study in the community-wide physical activity promotion project in Fujisawa City, 19 addresses were used, excluding those with nearby addresses. Results demonstrated “excellent” agreement for most of the summary scores analyzed (kappa or ICC values of 0.75 or higher [80.4 %]), while 6.5 % of items exhibited “good” agreement (ICC = 0.60–0.74). By contrast, only 13.0 % of the scales had ICC values lower than 0.60 (“fair” or “poor” reliability). The results illustrated high reliability for the grand summary scores and composite subscale measures. However, caution should be exercised when interpreting subscale scores for less frequently observed negative attributes and aesthetic/social characteristics. The results presented in this study support the application of online observations using MAPS-Global in urban areas of Japan, which could be implemented to inform decisions related not only to physical activity but also to traffic safety.

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Identification of dietary patterns and their relationship with physical performance in adults of 85 years of age and older -A cross sectional study from The Tokyo Oldest Old survey on Total Health study-

Yu Tao, Oguma Yuko, Asakura Keiko, Takayama Michiyo, Abe Yukiko, Arai Yasumichi

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (The Japan Geriatrics Society) 59 ( 4 ) 507 - 517 2022.10

ISSN 0300-9173

Aim: While the proportion of people of ≥85 years of age is expected to increase, there is limited research on the dietary patterns and physical performance of this population in Japan. The purpose of this study was to identify the dietary patterns of people of ≥85 years of age who live in Tokyo and to examine the relationship with their physical performance. Methods: Using data from the baseline survey (conducted in 2008-2009) of The Tokyo Oldest Old survey on Total Health study, the estimated 58 food intake items were aggregated into 33 items after energy adjustment, and a principal component analysis was performed. For physical performance, the results of grip strength, chair standing test, and 3 m timed up and go test conducted at normal walking speed were used. A multiple regression analysis was used to adjust for confounders and to examine the relationship between each dietary pattern and physical performance. Results: The subjects of the analysis were 87.3 (86.2-88.8) years of age (median [25-75th percentile] ). From the principal component analysis, three dietary patterns were identified: “various vegetable foods”, “fish and mushrooms”, and “cooked rice and miso soup”. A higher propensity for the “fish and mushrooms” dietary pattern was significantly associated with grip strength (partial regression coefficient, B (95% confidence interval): 0.48 (0.13-0.83) ). Conclusions: In a population of people of ≥85 years of age in Tokyo, a positive association was observed between hand grip strength and a dietary pattern characterized by fish and mushroom intake.

健康づくりのための身体活動指針の認知・知識・信念・行動意図の現状と身体活動・座位行動の関連

田島敬之, 原田和弘, 小熊祐子, 澤田亨

日本公衆衛生雑誌 (日本公衆衛生学会) 69 ( 10 ) 790 - 804 2022.10

ISSN 0546-1766

目的本研究では,アクティブガイドの認知・知識・信念・行動意図の現状と,身体活動・座位行動,個人属性との関連を明らかにする。方法オンライン調査会社に登録する20〜69歳のモニター7,000人を対象に,横断的調査を実施した。アクティブガイドの認知は,純粋想起法と助成想起法により,知識は「1日の推奨活動時間(18〜64歳/65歳以上)」と「今から増やすべき身体活動時間(プラス・テン)」を数値回答で調査した。信念と行動意図はアクティブガイドに対応する形で新たに尺度を作成し,信念の合計得点と行動意図を有する者の割合を算出した。身体活動は多目的コホート研究(JPHC study)の身体活動質問票から中高強度身体活動量を,特定健診・保健指導の標準的な質問票から活動レベルを算出した。座位行動は国際標準化身体活動質問表(IPAQ)日本語版を使用した。記述的要約を実施した後,従属変数を認知・知識・信念・行動意図のそれぞれの項目,独立変数を身体活動量,座位行動,個人属性(性別,年代,BMI,配偶者の有無,教育歴,仕事の有無,世帯収入)とし,ロジスティック回帰分析でこれらの関連を検討した。結果アクティブガイドの認知率は純粋想起法で1.7%,助成想起法で5.3〜13.4%であった。知識の正答率は,「1日の推奨活動時間(18〜64歳)」で37.2%,「1日の身体活動時間(65歳以上)」で7.0%,「プラス・テン」で24.8%,3項目すべて正答で2.6%だった。信念の中央値(四分位範囲)は21(16〜25)点であった(32点満点)。行動意図を有する者は,「1日の推奨活動量」で51.4%,「プラス・テン」で66.9%だった。ロジスティック回帰分析の結果,認知・知識・信念・行動意図は中高強度身体活動量や活動レベルでいずれも正の関連が観察された一方で,座位行動では一貫した関連は観察されなかった。個人属性は,評価項目によって異なるが,主に年代や教育歴,仕事の有無,世帯年収との関連を認めた。結論本研究より,アクティブガイドの認知や知識を有する者は未だ少ない現状が明らかとなった。さらにアクティブガイドの認知・知識・信念・行動意図を有する者は身体活動量が多いことが明らかとなったが,座位行動は一貫した関連が観察されず,この点はさらなる調査が必要である。さらに,今後は経時的な定点調査も求められる。(著者抄録)

Current status of awareness, knowledge, beliefs, and behavioral intentions regarding the Japanese physical activity guidelines and their relationship with physical activity and sedentary behavior

TAJIMA Takayuki, HARADA Kazuhiro, OGUMA Yuko, SAWADA Susumu S.

Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) (Japanese Society of Public Health) advpub ( 0 ) 790 - 804 2022.06

ISSN 0546-1766

Objective　This study clarified the current status of awareness, knowledge, beliefs, and behavioral intentions regarding the Japanese physical activity guidelines (Active Guide) and their relationship with physical activity, sedentary behavior, and the participants’ characteristics.Methods　A cross-sectional study was conducted with 7,000 participants aged 20-69 years registered with an online survey company. Awareness, knowledge, beliefs, and behavioral intentions regarding the Active Guide were examined. Awareness was assessed by unprompted and prompted recall. Knowledge was assessed by numerical responses to “the recommended daily activity time (18-64 years/65 years and older)” and “physical activity time to be increased (plus-ten),” respectively. To survey the beliefs and behavioral intentions, we created a 5-point scale for the Active Guide. For physical activity, the amount of moderate-to-vigorous intensity physical activity was calculated from the Japan Public Health Center-based prospective Study (JPHC study) questionnaire. Physical activity level was calculated from the standard specific medical checkup and health guidance questionnaire. For sedentary behavior, the Japanese version of the International Physical Activity Questionnaire (IPAQ) was used. The dependent variables were awareness, knowledge, beliefs, and behavioral intentions. The independent variables were physical activity, sedentary behavior, and the participants’ characteristics (gender, age, body mass index, marital status, educational background, work status, and household income). After descriptive statistics were measured, a logistic regression analysis was performed to examine the associations.Results　Unprompted and prompted recall of the Active Guide were 1.7% and 5.3-13.4%, respectively. Those with knowledge of it scored 37.2%, 7.0%, 24.8%, and 2.6% for recommended daily activity time (18-64 years), daily physical activity time (65 years and older), plus-ten, and all three items answered correctly, respectively. The median (interquartile range) score of the beliefs was 21 (16-25) points (32-point scale). Those with behavioral intentions scored 51.4% for “recommended daily activity” and 66.9% for “plus-ten.” Logistic regression analysis showed that awareness, knowledge, beliefs, and behavioral intentions were positively associated with moderate-to-vigorous intensity physical activity and level. The results were inconsistent for sedentary behavior. Although personal characteristics differed based on assessment item, they were mainly associated with age, education level, employment, and household income.Conclusions　This study revealed that the number of people who had awareness and knowledge of the Active Guide remained low. Those with awareness, knowledge, beliefs, and behavioral intentions were more physically active. However, the results for sedentary behavior were not consistent. Hence, further research is required to understand this tendency. A future longitudinal study is also required.

“Must Read Papers 20” in physical activity and exercise epidemiology (2009–2018)

Matsushita Munehiro, Kamada Masamitsu, Sasai Hiroyuki, Harada Kazuhiro, Momma Haruki, Inoue Shigeru, Nakata Yoshio, Oguma Yuko

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) 24 ( 1 ) 19 - 33 2022.06

ISSN 13475827

Objective: In 2009, “Must Read Papers 20 in Physical Activity and Exercise Epidemiology” was published in the journal, Research in Exercise Epidemiology. In the past decade, physical activity measurement, design, and analytical methods have been developed in the field of physical activity and exercise epidemiology; thus, research topics have evolved. Consequently, we selected “Must Read Papers 20 in Physical Activity and Exercise Epidemiology” among papers published after 2009 to provide useful information to researchers involved in this field.Methods: This study was conducted as a research project approved by the Japanese Association of Exercise Epidemiology (JAEE) and titled as “Must Read Papers 20 in Physical Activity and Exercise Epidemiology 2nd edition”. First, we extracted candidate papers that were recommended by JAEE members and the current project team. Next, the project team members prespecified the selection criteria and finally selected 20 papers through discussion.Results: We identified 39 candidate papers and selected 20 of them. Guidelines were excluded and the selected 20 papers included 12 observation studies, 5 intervention studies, 2 systematic reviews and meta-analyses, and 1 quasi-experimental study. Of them, 6 papers were from Japan.Conclusion: We selected “Must Read Papers 20 in Physical Activity and Exercise Epidemiology: 2009–2018.”Methodologies and research themes in this field will continue to evolve in future; therefore, it is desirable to select and introduce important papers periodically.

The impact pathways of environmental, social, and behavioural factors on healthy ageing for urban dwellers aged 85+: Longitudinal study of the Tokyo Oldest Old Survey on Total Health (TOOTH)

Yoshida N, Arai Y, Takayama M, Abe Y, Oguma Y

SSM - Population Health (SSM - Population Health) 18 101089 2022.06

Research paper (scientific journal), Joint Work, Last author, Corresponding author, Accepted, ISSN 2352-8273

In the context of global population ageing and concentration in cities, the population aged 80 and over (80+) is growing rapidly. Japan has the fastest ageing population and longest healthy average life expectancy, while health decline becomes pronounced and care needs increase in the 85+ age group post the ‘average life expectancy’. The healthy ageing of older urban community dwellers is a pressing issue in world initiatives for sustainable urbanisation. However, for the 85+ age group, less is known about how promoting/inhibiting factors and their pathways influence healthy ageing, and related longitudinal studies remain insufficient. Using data from a longitudinal cohort study conducted from 2008–2009 to 2014–2015 among independent dwellers aged 85+ in central Tokyo (men = 203, women = 232), this study analysed the impact pathways of environmental, social, and behavioural factors on health and survival to explore promoters and potential risks on healthy ageing by gender, with multi-group structural equation modelling (SEM) and Bayesian SEM. For both genders, there was a positive chained pathway starting from friends as facilitators through positive interactions between 'social participation’ and 'active behaviour' to 'ageing-related health'. Additionally, their personal networks were small, suggesting that men with family-centred networks and women with non-family-centred networks require different approaches and supports. Implications of the results are discussed, and an organised social watch and support system, which becomes more important in the ‘new normal’ for urban dwellers aged 85+, is recommended.

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Awareness of Active Guide, physical activity, and health literacy: a nationwide, cross-sectional Internet survey

HARADA Kazuhiro, TAJIMA Takayuki, OGUMA Yuko, SAWADA Susumu

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 30 ( 2 ) 103 - 114 2022.05

Accepted, ISSN 13402560

Objective: The purpose of this study was to examine whether 1) health literacy is associated with the awareness of the Japanese physical activity guidelines (Active Guide) and 2) health literacy moderates the association between awareness of Active Guide and physical activity.Methods: A nationwide, cross-sectional Internet survey of 7,000 Japanese adults was conducted. The survey items included those related to the awareness of Active Guide, two physical activity variables (amounts of moderate-to-vigorous physical activity and sufficient level of physical activity), health literacy, and demographic factors.Results: Logistic regression analysis revealed significant correlation between health literacy and the awareness of Active Guide. Furthermore, logistic and multiple regression analyses showed that the interaction term of health literacy with awareness of Active Guide was negatively and significantly correlated with physical activity variables. Further stratified analysis indicated that while awareness of Active Guide was significantly and positively correlated with physical activity among groups with low and high health literacy, regression coefficients for the low health literacy group were greater than those for the high health literacy group.Conclusion: The results implied that individuals with higher health literacy were more likely to be aware of Active Guide and that the positive association between the awareness of Active Guide and physical activity was stronger among those with lower health literacy than those with higher health literacy.

アクティブガイドの認知、身体活動およびヘルスリテラシー　横断デザインによる全国インターネット調査データより

原田和弘, 田島敬之, 小熊祐子, 澤田亨

日本健康教育学会誌 ((一社)日本健康教育学会) 30 ( 2 ) 103 - 114 2022.05

ISSN 1340-2560

目的:本研究では,ヘルスリテラシーがアクティブガイドの認知と関連しているかどうかと,ヘルスリテラシーの程度によって,アクティブガイドの認知と身体活動との関連性が異なるかどうかを検証した.方法:この横断研究では,社会調査会社の全国の調査モニター7,000名にインターネットによる質問紙調査を行い,アクティブガイドの認知,身体活動(中強度以上の身体活動量,身体活動レベル),ヘルスリテラシー,および基本属性の関連性を評価した.結果:アクティブガイドの認知を従属変数としたロジスティック回帰分析の結果,ヘルスリテラシー得点が有意に正の関連をしていた.身体活動の両指標を従属変数とした重回帰分析とロジスティック回帰分析の結果,アクティブガイドの認知とヘルスリテラシーとの交互作用項が有意に負の関連をしていた.ヘルスリテラシーの程度で層化した分析を行った結果,ヘルスリテラシー低群でもヘルスリテラシー高群でも,アクティブガイドの認知は身体活動の両指標と有意に正の関連をしていた.ただし,偏回帰係数やオッズ比は,ヘルスリテラシー高群よりもヘルスリテラシー低群のほうが大きかった.結論:本研究により,ヘルスリテラシーが高い人々のほうがアクティブガイドを認知している傾向にあること,および,ヘルスリテラシーが低い人々においてアクティブガイドの認知と身体活動との正の関連性が顕著な傾向にあることが明らかとなった.(著者抄録)

Symposium21-2 1964年東京オリンピック以降の身体活動・スポーツ政策の変遷

小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 71 ( 1 ) 97 - 97 2022

ISSN 0039-906X

Symposium20-1身体活動推進政策の認知度と政策展開

種田行男, 小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 71 ( 1 ) 91 - 91 2022

ISSN 0039-906X

Symposium20-3身体活動ガイドラインの認知・知識に関する評価法の課題と今後の展開

田島敬之, 小熊祐子, 齋藤義信, 澤田亨, 原田和弘

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 71 ( 1 ) 93 - 93 2022

ISSN 0039-906X

Symposium2-4慢性疾患有病者に対する身体活動基準レビュー班の取り組み

小熊祐子, 佐藤真治, 田村好史, 宮下政司, 齋藤義信, 田島敬之, 津下一代, 原藤健吾, 横山美帆

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 71 ( 1 ) 17 - 17 2022

ISSN 0039-906X

Symposium20-5アクティブガイドを活用した地域全体への多面的介入：藤沢市における取り組み

齋藤義信, 小熊祐子, 田島敬之, 伊藤智也

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 71 ( 1 ) 95 - 95 2022

ISSN 0039-906X

a Review on the Current Situation and Future Perspectives of the Studies on the Relationship Between Transportation and Health in Japan

G Hayauchi, R Ariyoshi, Y Saito, Y Oguma, S Nakamura, F Nakamura

Journal of Japan Society of Civil Engineers, Ser. D3 (Infrastructure … (Japan Society of Civil Engineers) 77 ( 5 ) I_583 - I_593 2022

ISSN 2185-6540

Physical activities associated with mobility are assumed to have a reciprocal relationship with the health condition. With the social momentum, including the extension of healthy life expectancy, health would be an essential element in future transportation planning. In this study, we summarize the existing studies on the relationship between mobility and health in Japan from the viewpoint of health-related indicators, mobility-related indicators, and their combinations. We clarified that both mobility- and health-related indicators could be divided into those commonly adopted by multiple studies and those independently adopted. In addition, while indicators related to awareness and intentions and manifest mobility and health status may be necessary, there are issues in applying standardized measurement methods.

Relationship between Dietary Patterns and Subjectively Measured Physical Activity in Japanese Individuals 85 Years and Older: A Cross-Sectional Study

T Yu, Y Oguma, K Asakura, M Takayama, Y Abe, Y Arai

Nutrients 14 (14), 2924 (Nutrients) 14 ( 14 ) 2022

High-quality diets and regular physical activity (PA) are considered healthy behaviors (HBs). HBs are associated with many health outcomes and are expected to improve quality of life. Although implementing HBs is important, the relationship between dietary patterns (DPs) and PA has not been well investigated, especially among those aged ≥ 85. This study used data from the Tokyo Oldest Old survey on Total Health study to examine the relationship between DPs and PA in a cross-sectional study. The dietary survey used the brief self-administered diet history questionnaire to estimate the intake of 58 foods. After energy adjustment, principal component analysis was performed to identify major DPs. A validated questionnaire was used to evaluate PA, and linear regression analysis was used to investigate the association between DPs and PA, considering confounders. A total of 519 participants were included. Three major DPs ('Various plant foods', 'Fish and mushrooms', 'Cooked rice and miso soup') were identified. 'Various plant foods' was similar to DPs previously named 'Healthy' or 'Prudent', and its trend was positively associated with higher PA. This study observed the implementation of HBs even among those aged ≥ 85, suggesting that a trend toward a healthier diet is associated with higher PA.

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Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly

R Hata, K Miyamoto, Y Abe, T Sasaki, Y Oguma, T Tajima, Y Arai, ...

Bone, 116570 (Bone) 166 116570 - 116570 2022

ISSN 8756-3282

It is mandatory to manage musculoskeletal disorders in the elderly to prevent their becoming bed-ridden or requiring long-term care. However, the prevalence of musculoskeletal disorders such as osteoporosis and sarcopenia in otherwise healthy people over 85 years old is not completely known. Here we enrolled 1026 healthy subjects between 85 and 89 years old and evaluated them for the presence of osteoporosis, sarcopenia and fragility fracture(s), and how those conditions were related. We also evaluated biomarkers such as serum levels of insulin-like growth factor 1 (IGF1) and vitamin D status. The prevalence of osteoporosis, sarcopenia or fragility fracture(s) in these subjects was 22.4, 10.2 or 15.0 %, respectively. Serum IGF1 and 25(OH)D were significantly and negatively correlated with osteoporosis or sarcopenia. Osteoporosis and either sarcopenia or fragility fracture(s) were significantly related and shown to be risk factors for each other, even after adjustment for gender and BMI, while sarcopenia and fragility fracture(s) were not associated. Our data may provide a health platform for the very elderly and suggest strategies to prevent musculoskeletal disorders in this population.

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Ice slurry ingestion improves physical performance during high-intensity intermittent exercise in a hot environment

A Morito, T Inami, A Hirata, S Yamada, M Shimomasuda, M Haramoto, ...

PloS one 17 (9), e0274584 (PLoS ONE) 17 ( 9 ) e0274584 2022

ISSN 1932-6203

Ice slurry ingestion enhances exercise performance by lowering the core body temperature. However, an operational issue related to this ingestion is the requirement for a high intake of 7.5 g·kg-1 to produce the desired effects. We investigated the effects of the intake of low amounts of ice slurry at -2°C on the tympanic temperature and exercise performance during repeated high-intensity intermittent exercises in a hot environment. This study was a randomized, crossover study, with a 6-day washout period. Twelve university rugby union players performed two 30-min sessions of high-intensity intermittent exercises separated by a 15-min half-time break on a cycle ergometer in a hot environment (28.8°C ± 0.1°C, 49.5% ± 0.6% relative humidity). The participants ingested 450 g of -2°C-ice slurry (ICE), or a 30°C-beverage (CON) having the same composition as ICE, or 30°C-water (WAT) during the half-time break. The tympanic temperature and skin temperature were measured as the physiological data, and the peak power and mean power as the exercise performance data. The tympanic temperature at the half-time break and beginning of the 2nd session was significantly lower in the ICE group as compared with the CON and WAT groups. The skin temperature at the half-time break was significantly lower in the ICE group as compared with the WAT group. While the peak power and mean power during the 2nd session were significantly greater in the ICE group as compared with the CON and WAT groups. Our findings suggest that even the intake of lower amounts, as compared with those used in previous studies, of low-temperature ice slurry can reduce the body temperature and improve the peak power. These results suggest that intake of low-temperature ice slurry as a strategy for internal body cooling is useful for improving endurance exercise performance in hot environments.

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Monitoring of Post-Brain Injuries By Measuring Plasma Levels of Neuron-Derived Extracellular Vesicles

N Hotta, T Tadokoro, J Henry, D Koga, K Kawata, H Ishida, Y Oguma, ...

Biomarker Insights 17, 11772719221128145 (Biomarker Insights) 17 11772719221128145 - 117727192211281 2022

ISSN 1177-2719

Background: Extracellular vesicles (EV) released from neurons into the blood can reflect the state of nervous tissue. Measurement of neuron derived EV (NDE) may serve as an indicator of brain injury. Methods: A sandwich immunoassay was established to measure plasma NDE using anti-neuron CD171 and anti-EV CD9 ([CD171 + CD9+]). Plasma samples were obtained from commercial sources, cross-country (n = 9), football (n = 22), soccer (n = 19), and rugby (n = 18) athletes over time. Plasma was also collected from patients undergoing total aortic arch replacement (TAR) with selective cerebral perfusion during cardiopulmonary bypass before and after surgery (n = 36). Results: The specificity, linearity, and reproducibility of NDE assay (measurement of [CD171 + CD9+]) were confirmed. By scanning electron microscopy and nanoparticle tracking, spherical vesicles ranging in size from 150 to 300 nm were confirmed. Plasma levels of NDE were widely spread over 2 to 3 logs in different individuals with a significant age-dependent decrease. However, NDE were very stable in each individual within a ± 50% change over time (cross-country, football, soccer), whereas rugby players were more variable over 4 years. In patients undergoing TAR, NDE increased rapidly in days post-surgery and were significantly (P =.0004) higher in those developing postoperative delirium (POD) (n = 13) than non-delirium patients (n = 23). Conclusions: The blood test to determine plasma levels of NDE was established by a sandwich immunoassay using 2 antibodies against neuron (CD171) and exosomes (CD9). NDE levels varied widely in different individuals and decreased with age, indicating that NDE levels should be considered as a normalizer of NDE biomarker studies. However, NDE levels were stable over time in each individual, and increased rapidly after TAR with greater increases associated with patients developing POD. This assay may serve as a surrogate for evaluating and monitoring brain injuries.

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加速度計で調査した地域在住高齢者の身体活動：川崎市における高齢者の暮らし方と健康に関する学術調査

小熊祐子, 新井康通

運動疫学 (Japanese Association of Exercise Epidemiology) - ( 1 ) 50 - 51 2022

Accepted, ISSN 13475827

Association between dietary patterns and subjective and objective measures of physical activity among Japanese adults aged 85 years and older: a cross-sectional study

T Yu, Y Oguma, K Asakura, Y Abe, Y Arai

British Journal of Nutrition, 1-29 (The British journal of nutrition) 130 ( 6 ) 1 - 10 2022

ISSN 0007-1145

A healthy diet and regular physical activity (PA) are delineated as healthy behaviours. Their implementation is associated with better health outcomes and improved quality of life. There is less evidence of a relationship between dietary patterns (DP) and PA, especially in adults aged ≥ 85. Hence, this cross-sectional study investigates the association between DP and PA in people of this age group, using the data from The Kawasaki Aging and Well-Being Project. Brief-type self-administered diet history questionnaire was used to estimate the intake of fifty-eight types of food. After energy adjustment, principal component analysis was performed to identify DP. PA was measured objectively using an accelerometer and subjectively using a questionnaire validated for this age group. Thousand participants (median age: 86·9 years, men: 49·9 %) were included in the analysis. Three major DP (DP1 'various foods', DP2 'red meats and coffee', DP3 'bread and processed meats') were identified. DP1 'various foods' was similar to DP previously named 'healthy' or 'prudent' and showed a positive association with PA time (PAT) as measured by accelerometer (B, 6·25; 95 % CI 0·13, 12·37) and relatively shorter sedentary behaviour (SB) time. DP2 'red meats and coffee' and DP3 'bread and processed meats' were negatively associated with PAT and positively associated with SB time. This study observed the relationship between diet and PA behaviours in adults aged ≥ 85, with healthier and more food-diverse DP associated with longer PAT and relatively unhealthy DP with shorter PAT.

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Current status of awareness, knowledge, beliefs, and behavioral intentions regarding the Japanese physical activity guidelines and their relationship with physical activity and …

T Tajima, K Harada, Y Oguma, SS Sawada

[Nihon Koshu Eisei Zasshi] Japanese Journal of Public Health 2022

The impact pathways of environmental, social, and behavioural factors on healthy ageing for urban dwellers aged 85+: Longitudinal study of the Tokyo Oldest Old Survey on Total …

N Yoshida, Y Arai, M Takayama, Y Abe, Y Oguma

SSM-Population Health 18, 101089 2022

Identification of dietary patterns and their relationship with physical performance in adults of 85 years of age and older-A cross sectional study from The Tokyo Oldest Old …

T Yu, Y Oguma, K Asakura, M Takayama, Y Abe, Y Arai

Nihon Ronen Igakkai zasshi. Japanese Journal of Geriatrics 59 (4), 507-517 2022

JMIR Aging

K Tabira, Y Oguma, S Yoshihara, M Shibuya, M Nakamura, N Doihara, ...

Journal Impact Factorâ¢(JIF) 2022

Behavioral changes and hygiene practices of older adults in Japan during the first wave of COVID-19 emergency

Y Arai, Y Oguma, Y Abe, M Takayama, A Hara, H Urushihara, ...

BMC geriatrics 21 (1), 1-9 (BMC Geriatrics) 21 ( 1 ) 137 2021.12

Background: On April 7, 2020, Japan declared a state of emergency due to the first wave of coronavirus disease 2019 (COVID-19) with the associated social distancing likely to have had a great impact on older adults’ lifestyle and health. This study aimed to explore the behavioral changes and personal hygiene practices in relation with background psychosocial and health characteristics of older adults during the COVID-19 emergency. Methods: A cross-sectional telephonic survey was conducted with the participants of the Kawasaki Aging and Wellbeing Project (KAWP), an on-going longitudinal cohort study of older adults aged 85 or older. The interviews were conducted using a structured questionnaire consisting of 11 closed questions regarding behavioral changes and personal hygiene practices during the state of emergency. Sociodemographic and health data were obtained from the KAWP baseline survey conducted 2.2 years before the telephonic survey. Results: Overall, 487 participants from the KAWP responded to the telephonic survey (response rate: 89.2%). 94.5% of the respondents reported no changes in basic lifestyle habits, such as eating, sleeping, smoking, and drinking, whereas 28.1% reported a decrease in physical activity, and 54.6% reported going out less frequently. One-third of the respondents reported a decrease in the number of people to converse with, as well as the amount of time to converse. For personal hygiene practices, 93.8% reported wearing a mask when they went out, and 50.3% reported an increased frequency of handwashing. Multiple logistic regression analysis revealed that engagement in physical activity at baseline (odds ratio [OR] = 1.95, 95% confidence interval [CI] = 1.23–3.08), smartphone ownership (OR = 2.15, 95% CI = 1.33–3.47), and visual impairment (OR = 1.79; 95% CI = 1.10–2.91) were independently associated with decreased physical activity during the COVID-19 emergency. Female respondents and smartphone ownership were significantly associated with more frequent handwashing. Conclusions: The study revealed that older adults in an urban setting responded to the COVID-19 emergency with behavioral changes. The findings of this study have implications for the design of preventive strategies to maintain the health and wellbeing of at-risk older adults.

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Changes In Physical Activity And Health Indicators In The Covid-19 Disasters: Results Of A Mail Questionnaire Survey Of Community-based Group Exercise Elderly Participants In Fujisawa, Japan

Oguma Yuko, Doihara Natsue, Saito Yoshinobu, Ito Tomoya, Tajima Takayuki

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 53 ( 8 ) 193 - 193 2021.08

Joint Work, ISSN 0195-9131

Physical activity and all-cause mortality and mediators of the association in the very old

Y Osawa, Y Abe, M Takayama, Y Oguma, Y Arai

Experimental Gerontology 150, 111374 (Experimental Gerontology) 150 111374 - 111374 2021.07

Research paper (scientific journal), Joint Work, ISSN 05315565

Background and objective: Physical activity (PA) confers protection to individuals from the risk of death. However, in the very old, the dose-response relationship between PA and all-cause mortality and the possible biological mediators of this association are less known. We investigated whether PA predicts 6-year all-cause mortality and what biomarkers mediate the association. Design: Prospective cohort data from the Tokyo Oldest Old Survey on Total Health study. Setting: Community-dwelling population. Participants: A total of 441 women and men aged over 85 years. Measurements: Questionnaire-based PA was assessed at baseline and 3-year and 6-year follow-up visits. Survival status was confirmed up to the 6-year follow-up visit (153 deaths, 34.7%). Data of plasma albumin, cholinesterase, NT-proBNP, interleukin-6, cystatin C, and HbA1c levels were collected. For mediation analysis for survival analysis, we used the baseline PA and biomarkers with Weibull distribution accelerated failure time model and linear regression model adjusted for age, sex, body mass index, smoking, education level, and Mini-Mental State Examination. Results: A curvilinear relationship was observed in the association between baseline PA and all-cause mortality. Compared to the inactive (0 METs*h/week), light amount of PA was associated with a lower risk of mortality. Compared to the highest tertile of PA (11.2 METs*h/week), higher PA did not reduce the risk of death. Circulation levels of albumin and cholinesterase mediated the association between baseline PA and all-cause mortality (proportion mediated, 54%, both; p < 0.05). Conclusions: Compared to completely inactive, light PA reduces the risk of all-cause mortality in the very old population. Mediation analysis suggests that protein synthesis in the liver may mediate the association between PA and all-cause mortality. Further studies are needed to understand the underlying association between PA, nutrition, and death.

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Functional status and instrumental activities of daily living after transcatheter aortic valve replacement

S Fukui, M Kawakami, K Hayashida, A Ishikawa, N Mori, Y Oguma, ...

Topics in Geriatric Rehabilitation 37 (2), 128-131 (Topics in Geriatric Rehabilitation) 37 ( 2 ) 128 - 131 2021.04

Research paper (scientific journal), Joint Work, ISSN 08827524

The purpose of this study was to investigate changes over time in instrumental activities of daily living (IADL), physical function, physical frailty, cognitive function, and nutritional status after transcatheter aortic valve implantation (TAVI). Fifty consecutive older patients with aortic stenosis as possible candidates for TAVI were prospectively enrolled. Their average age was 84.6 ± 3.1 years, and 39 (78%) were female. The results of the linear mixed-effects model for the isometric knee extension muscular strength showed a significant change. IADL and nutritional status were significantly different preoperatively compared with 6 months postoperatively after transfemoral TAVI.

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成人における冬季の住宅内の暖房使用と座位行動および身体活動スマートウェルネス住宅調査による横断研究

伊藤真紀, 伊香賀俊治, 小熊祐子, 齋藤義信, 藤野善久, 安藤真太朗, 村上周三, スマートウェルネス住宅調査グループ

運動疫学研究: Research in Exercise Epidemiology (日本運動疫学会) 23 ( 1 ) 45 - 56 2021.03

Joint Work, ISSN 1347-5827

目的:成人を対象に,冬季の暖房使用と住宅内の座位行動および身体活動の関連を検討すること。方法:本研究は横断研究である。調査は沖縄県を除く46都道府県の工務店等を通して募集した断熱改修工事予定のある住宅に居住する20歳以上の成人を対象に2014年度から2017年度までの冬季(11月〜4月)に実施し,3,874名から同意を得た。加速度計は連続14日間の装着を依頼した。行動日誌から覚醒在宅時間帯を特定し,住宅内の座位行動と身体活動を評価した。コタツおよび脱衣所暖房使用の有無と住宅内の座位行動,身体活動との関連は目的変数を対数変換したうえで,日レベル(室温,オフセット項として覚醒在宅時加速度計装着時間等),個人レベル(年齢,BM等),世帯レベル(世帯年収,同居人数等)で調整した線形混合モデル(ランダム切片モデル)を男女別に実施した。非標準化偏回帰係数は指数変換し,目的変数への関連の程度を算出した。結果:有効データは3,482名であった。多変量解析の結果,コタツを使用しない場合は住宅内の座位行動時間が約2%短く[男性:exp(B)=0.98,p=0.022,女性:exp(B)=0.98,p=0.020],その中断回数は約10%多く[男性:exp(B)=1.10,p=0.001,女性:exp(B)=1.11,p<0.001],身体活動も5〜7%多かった[男性:exp(B)=1.07,p=0.005,女性:exp(B)=1.05,p=0.012]。脱衣所を暖房する場合も同様の関連が確認された。結論:コタツを使用しない人,脱衣所を暖房する人は,住宅内の座位行動時間が短く,かつ頻繁に中断し,身体活動量も多かった。局所暖房を使用せず,非居室でも暖房を行い家を暖かく保つことは,住宅内の座位行動を抑制し身体活動を促進する可能性がある。(著者抄録)

身体活動ガイドラインの認知・知識の評価方法、並びに身体活動量との関連性についてのレビュー

田島敬之, 齋藤義信, 小熊祐子

運動疫学研究: Research in Exercise Epidemiology (日本運動疫学会) 23 ( 1 ) 15 - 35 2021.03

Joint Work, ISSN 1347-5827

目的:本研究は,成人を対象とした身体活動ガイドラインにおける認知・知識の評価方法の特性や,身体活動ガイドラインの認知・知識と身体活動量の関連について網羅的なレビューを実施することで,これまでの国内外の研究動向を整理し,今後の研究課題の探索と提言を行うことを目的とした。方法:データベースはPubMed,PsycINFO,医中誌を用いた。検索語は「ガイドライン」,「認知または知識」,「身体活動または座位行動」に関するキーワードが含まれるように選定し,検索式を設計した。設定した適格基準を基にスクリーニングを実施して採択の可否を判定し,論文の概要を抽出した。結果:2001年以降に発表された25編を採択した。身体活動ガイドラインの認知の評価方法は純粋想起法と助成想起法に大別された。純粋想起法と身体活動量の間には正の関連を認めたが,助成想起法では結果が一貫していなかった。ガイドラインの知識の評価方法は多様であり,推奨量を数値で回答させる評価方法が多かった。ガイドラインの知識では,推奨量を数値で回答させる・選択肢から適切な推奨量を回答させる研究で身体活動量との正の関連を認めた研究が多かった。座位行動を評価した研究は1編のみであった。結論:身体活動ガイドラインの認知・知識の評価方法は,研究間で異なっており,身体活動量との関連は結果が一貫していなかった。認知・知識の評価方法の確立と客観的な身体活動・座位行動の評価による研究の蓄積が今後の課題である。(著者抄録)

Relationship of stress response, coping and lifestyle with premenstrual syndrome in female university athletes: A structural equation modeling

Tani M, Oguma Y, Saito Y, Ishida H

Japanese Journal of Physical Fitness and Sports Medicine (Japanese Journal of Physical Fitness and Sports Medicine) 70 ( 1 ) 109 - 116 2021.02

Joint Work, ISSN 0039-906X

To date, there has been no comprehensive study on the relationship of stress response, coping and lifestyle (e.g., diet, exercise habits, and sleeping habits) with premenstrual syndrome (PMS) for female athletes. This study aimed to examine this relationship. We used a web questionnaire to acquire the required data from Japanese female university athletes. Based on structural equation modeling, we used the PMS score as an outcome and examined its relationship to stress response, emotion-focused coping, dietary intake, amount of exercise in club activities surveyed by club unit, and sleeping time. Our study included 257 subjects (average age, 20 years). The results showed that the stress response was a direct factor in the PMS score (standardized coefficient:.63). Emotion-focused coping and dietary intake were associated with PMS scores through stress response (-.26 and -.27, respectively). Emotion-focused coping was also associated with the dietary intake (.19). Factors associated with emotion-focused coping were amount of exercise (.22) and sleeping time (.27). The amount of exercise was associated with sleeping time (-.26). These results suggest that avoiding stressors, enhancing emotion-focused coping, reducing the stress response by maintaining a balanced and sufficient diet, performing an appropriate amount of exercise, and improving sleep habits may be effective in managing PMS.

Hierarchical Topic Model for Tensor Data and Extraction of Weekly and Daily Patterns from Activity Monitor Records.

S Nomura, M Watanabe, Y Oguma

PAKDD (Workshops), 17-30 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)) 12705 LNAI 17 - 30 2021

Joint Work, ISSN 0302-9743

Latent Dirichlet allocation (LDA) is a popular topic model for extracting common patterns from discrete datasets. It is extended to the pachinko allocation model (PAM) with a hierarchical topic structure. This paper presents a combination meal allocation (CMA) model, which is a further enhanced topic model from the PAM that has both hierarchical categories and hierarchical topics. We consider count datasets in multiway arrays, i.e., tensors, and introduce a set of topics to each mode of the tensors. The topics in each mode are interpreted as patterns in the topics and categories in the next mode. Despite there being a vast number of combinations in multilevel categories, our model provides simple and interpretable patterns by sharing the topics in each mode. Latent topics and their membership are estimated using Markov chain Monte Carlo (MCMC) methods. We apply the proposed model to step-count data recorded by activity monitors to extract some common activity patterns exhibited by the users. Our model identifies four daily patterns of ambulatory activities (commuting, daytime, nighttime, and early-bird activities) as sub-topics, and six weekly activity patterns as super-topics. We also investigate how the amount of activity in each pattern dynamically affects body weight changes.

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A community-wide intervention to promote physical activity: A five-year quasi-experimental study

Y Saito, A Tanaka, T Tajima, T Ito, Y Aihara, K Nakano, M Kamada, ...

Preventive Medicine, 106708 (Preventive Medicine) 150 106708 - 106708 2021

Joint Work, ISSN 0091-7435

Evidence on the effects of a community-wide intervention (CWI) on population-level physical activity (PA), especially in the long term, is limited. Therefore, we evaluated the five-year effect of CWI on promoting PA through information dissemination, education, and community support primarily targeting older adults, by incorporating Japanese guidelines, in Fujisawa City, from 2013. To assess the effect of the whole-city intervention, we distributed questionnaires in 2013, 2015, and 2018 to three independent random samples of 3,000 community-dwelling adults (aged ≥ 20 years) using a quasi-experimental study design. Three separate samples responded to the survey (41% at baseline, 46% at the two-year mark, and 48% at the five-year follow-up). The primary outcome was change in PA participation. At the five-year follow-up, PA (median: 120 minutes/day) was significantly higher than at baseline (86 minutes/day) and the two-year follow-up (90 minutes/day). The results of the multivariate analysis indicated that PA among older adults—the primary target population of the CWI—increased significantly at the five-year follow-up, compared to those aged 20–64 (mean difference of change between groups: 14.7 minutes/day, P= 0.029). Among older adults, PA was significantly lower in those with poorer perceived economic status than in their more well-off counterparts at the two-year follow-up (P= 0.003); however, there was no significant difference at the five-year follow-up (P= 1.000). There was a positive interaction between group and period (mean difference of change between groups: 40.9 minutes/day, P= 0.001). In conclusion, the five-year CWI targeting older adults, incorporating national guidelines, improved population-level PA.

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Symposium7-5高齢者およびサルコペニアを有する人を対象にした運動プログラムの作成

齋藤義信, 小熊祐子

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 70 ( 1 ) 34 - 34 2021

ISSN 0039-906X

Symposium17-2身体活動に関する世界行動計画2018-2030（GAPPA）の紹介と日本での展開について

小熊祐子, 齋藤義信

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 70 ( 1 ) 62 - 62 2021

ISSN 0039-906X

Symposium7-3疾患別運動プログラム（肥満・メタボリックシンドローム, がんサバイバー）と指定運動療法施設・医療機関の連携について

小熊祐子, 齋藤義信

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 70 ( 1 ) 33 - 33 2021

ISSN 0039-906X

Heating use and sedentary behavior and physical activity at home among adults in winter: a cross-sectional analysis of the nationwide Smart Wellness Housing Survey in Japan

Ito Maki, Ikaga Toshiharu, Oguma Yuko, Saito Yoshinobu, Fujino Yoshihisa, Ando Shintaro, Murakami Shuzo, the Smart Wellness Housing Survey group

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) 23 ( 1 ) 45 - 56 2021

ISSN 1347-5827

Objective: This study examined the association between use of heating and sedentary behavior (SB) and physical activity (PA) at home among Japanese adults in winter.Methods: This cross-sectional study was conducted from November to April from 2014 to 2017. Participants (n=3,874) who intended to conduct insulation retrofitting were recruited by construction companies from 46 prefectures excluding Okinawa Prefecture and wore an accelerometer on their waist for 2 weeks. The association between heating use and log-transformed SB and PA at home was analyzed using a sex-stratified multilevel model (random-intercept model) with 3 levels; day-level variables (e.g., indoor temperature and log-transformed accelerometer wear time as an offset), nested within individual-level (e.g., age and body mass index), and nested within household-level (e.g., household income, number of housemates). The degree of association with the dependent variable was given by exponential transforming the unstandardized regression coefficient.Results: Data from 3,482 participants were analyzed. In the multilevel model, not using a kotatsu was associated with about 2% shorter SB time [men: exp(B)=0.98, p=0.022; women: exp(B)=0.98, p=0.020], an about 10% greater number of breaks in SB time [men: exp(B)=1.10, p=0.001; women: exp(B)=1.11, p<0.001], and 5-7% greater PA [men: exp(B)=1.07, p=0.005; women: exp(B)=1.05, p=0.012] than using a kotatsu. Heating the changing room was also related to shorter SB time, a greater number of breaks in SB time and greater PA in men and women.Conclusions: Not using a kotatsu and heating the changing room were associated with shorter SB and greater PA at home. Warming by heating the entire home, rather than partially heating just the living room, may decrease SB and increase PA in winter.

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Symposium3-7慢性疾患有病者に対する身体活動基準案の作成・方向性の検討

小熊祐子, 齋藤義信, 佐藤真治, 田島敬之, 田村好史, 津下一代, 宮下政司

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 70 ( 1 ) 19 - 19 2021

ISSN 0039-906X

A descriptive epidemiological study of injuries and illnesses over an 8-year period in a Japanese university rugby football team

Hirata Akihiro, Oguma Yuko, Ishida Hiroyuki

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) 23 ( 2 ) 143 - 152 2021

Joint Work, ISSN 1347-5827

Objective: To clarify the incidence rates of sports injuries, including those due to trauma, overuse, and diseases, a descriptive epidemiological study was conducted in players from the Keio University rugby football club. Methods: The study participants were 368 players who belonged to the Keio University rugby football club from April 2011 through December 2018 (1,049 players/year). We analyzed the incidence per practice day and game, by clinical department category and disease classification, and by unplayable period and severity of the sports injury and disease that led to leave from practice and game during the study period. In addition, we analyzed the incidence of sports injuries and diseases by body part affected, month of onset, orthopedic and neurosurgical disease statuses, and year and month of onset of internal diseases according to clinical department and disease classification. Results: The incidence of sports injuries and diseases was 1.67 cases/player overall, 1.07 cases/player in the orthopedic diseases, 0.25 case/player in the internal diseases, and 0.24 case/player in the neurosurgical diseases (all concussions) over 8 years. The incidence rates per practice day and game were 0.41 and 1.18 cases, respectively. The conditions with the highest incidence rates were as follows: orthopedic diseases of the lower limb, 45%; ligament injuries, 46%; common cold, 40% of all internal diseases; and seasonal and annual cases of gastroenteritis, 35%. Conclusion: This study shows that many cases of ligament injuries of the lower limb were treated as orthopedic diseases; and common cold and gastroenteritis, as internal diseases. All cases of concussion were treated as neurosurgical diseases. Given these facts, steps must be taken to secure the duration of a play.

Introduction of "Eight Investments That Work for Physical Activity" Japanese version

Amagasa Shiho, Matsushita Munehiro, Tajima Takayuki, Komura Keisuke, Nakata Yoshio, Oguma Yuko, Inoue Shigeru, Oka Koichiro

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) 23 ( 2 ) 183 - 189 2021

ISSN 1347-5827

In November 2020, the International Society for Physical Activity and Health (ISPAH) published “Eight Investments That Work for Physical Activity". This document was updated from ISPAH's 2011 publication: ”Non Communicable Disease Prevention: Investments That Work for Physical Activity (2011)” following the “Toronto Charter on Physical Activity: A Global Call for Action” published in 2010. Along with the “WHO Global Action Plan on Physical Activity 2018-2030”, this is useful as guidance for promoting physical activity. This document emphasized that physical activity promotion will not only improve people's health, but also contribute to a better society and the achievement of the Sustainable Development Goals (SDGs) developed by the United Nations. The strategy to promote physical activity is based on a systems-based approach, which recommends measures in eight areas: 1) whole-of-school programmes, 2) active transport, 3) active urban design, 4) healthcare, 5) public education, including mass media, 6) sport and recreation for all, 7) workplaces, and 8) community-wide programmes. This paper outlines the document and introduces its Japanese translation version.

HAL腰タイプを使用した運動プログラムがフレイル状態にある高齢者の運動Self efficacyへ与える影響について

長澤誠, 中村翔, 小熊祐子, 齋藤義信, 粕川隆士, 成松宏人

Congress of the Japanese Physical Therapy Association (JAPANESE PHYSICAL THERAPY ASSOCIATION) 48 ( 0 ) B - 202_1-B-202_1 2021

Joint Work

The 2020 Yokohama Sports Conference and the future perspectives on exercise epidemiology

Kuwahara Keisuke, Namba Hideyuki, Takeda Noriko, Saito Yoshinobu, Oguma Yuko, Inoue Shigeru

Research in Exercise Epidemiology (Japanese Association of Exercise Epidemiology) 23 ( 1 ) 84 - 91 2021

Joint Work, ISSN 1347-5827

The 2020 Yokohama Sport Conference, an international conference in harmony with the 2020 Olympic and Paralympic Games, was initially planned to be held in Yokohama from 8 to 12 September, 2020. However, the COVID-19 pandemic significantly affected the conference; the conference style and dates were changed and many programs were altered or cancelled. All sessions in which Japanese Association of Exercise Epidemiology was involved were also cancelled. Then, owing to the stakeholders' passions, kind understanding and help, we replanned and held online lectures and a talk by Dr. Fiona Bull (Head of Physical Activity Unit, Department of Health Promotion, Division of Healthier Populations, World Health Organization) and Dr. Daichi Suzuki (Commissioner, Japan Sports Agency) on September 9, 2020 as a public program, connecting Switzerland and Japan in real-time. As we could not have enough time for discussions among participants of the public program, we also held an online reflection session on the following day. Here, we summarize the process and contents of these sessions and discuss future perspectives, based on the findings from the sessions as an implementation of dissemination of exercise epidemiology.

Translating GAPPA into local government policy–the example of Fujisawa City, Japan: Mini-Oral Presentation A3. 13

Y Oguma, Y Saito, T Tajima, T Ito, T Yu, N Doihara, N Takeda, Y Oida

The Health & Fitness Journal of Canada 14 (3) 2021

Physical activity, social capital and health status among older adults: a structural equation modeling analysis: Mini-Oral Presentation A3. 10

Y Saito, Y Oguma, H Imamura, T Tajima, S Nakamura, K Watanabe, ...

The Health & Fitness Journal of Canada 14 (3) 2021

Adverse events and near-misses during sports activities conducted independently by community residents: Mini-Oral Presentation A3. 15

A Hirata, Y Oguma, T Hashimoto, S Hosoi, R Segawa, M Shirakawa

The Health & Fitness Journal of Canada 14 (3) 2021

Association between Indoor Climate of Elementary School Classrooms and Children's Physical Activity/ Learning Efficiency

馬場暁子, 伊香賀俊治, 小熊祐子, 福島富士子, 富岡由美, 峰友紗

Techinical Papers of Annual Meeting the Society of Heating,Air-conditioning and Sanitary Engineers of Japan (The Society of Heating,Air-Conditioning&Sanitary Engineers of Japan) 2021.8 ( 0 ) 269 - 272 2021

ISSN 18803806

社会情勢の変化により、児童の学力育成が重要視されている近年、児童が過ごす教室の温熱・空気環境が、児童の学習効率に影響することに加えて、身体活動が学習効率に与える影響について様々な報告がなされており、身体活動促進が児童・生徒の学力向上に寄与する可能性が示されている。そこで本研究では、教室の温熱・空気環境に加えて、児童の日常的な身体活動量が総合的に児童の学習効率に及ぼす影響を、計算作業成績を用いて客観的に評価することを目的とした。

Serum Lactate Dehydrogenase is a Predictive Biomarker in Oropharyngeal Cancer Patients Undergoing Radiotherapy

T Uehara, H Doi, K Ishikawa, S Tatsuno, Y Wada, Y Oguma, M Inada, ...

International Journal of Radiation Oncology, Biology, Physics 111 (3), e397-e398 2021

特集日本型MPH教育の軌跡と展望-公衆衛生専門職を目指す!生かす! 国内でMPHを取得した者の活躍状況

小熊祐子

公衆衛生 (株式会社医学書院) 84 ( 11 ) 743 - 748 2020.11

ISSN 03685187

Correction: The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes

M Matsushita, A Muramoto, E Nomura, Y Eguchi, A Kato, Y Sano, ...

Nutrition & Diabetes 10 (1), 1-1 (Nutrition and Diabetes) 10 ( 1 ) 34 - 34 2020.09

Joint Work

Access to Document (DOI)

Preoperative Instrumental Activities of Daily Living Predicts Survival After Transcatheter Aortic Valve Implantation

S Fukui, M Kawakami, Y Otaka, A Ishikawa, F Yashima, K Hayashida, ...

Circulation Reports, CR-19-0109 (一般社団法人日本循環器学会) 2 ( 2 ) 83 - 88 2020

Joint Work

Background:This aim of this study was to clarify prognosis after transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis (AS) and to identify baseline factors associated with mortality.Methods and Results:We prospectively enrolled 257 consecutive elderly persons with AS who were referred to Keio University Hospital and who underwent assessment of cardiac, physical (walking speed), cognitive, and renal functions, nutritional status, activities of daily living (ADL), instrumental ADL (IADL) assessed with the Frenchay activities index (FAI), and comorbidities. The primary outcome was postoperative death. Differences in basic characteristics were compared between a group that survived for a median of 661 days (IQR, 0–1,289 days) after TAVI and a group that did not. Multivariate hazard ratios (HR) were calculated for independent factors selected in Cox proportional hazard models. Thirty-one individuals died during follow-up. Walking speed was significantly faster (0.87±0.25 vs. 0.70±0.24 m/s, P<0.001) and FAI was significantly higher (21.2±8.0 vs. 15.7±8.0, P=0.026) in the survival group compared with those who died. Multivariate HR for mortality according to walking speed was 0.05 (95% CI: 0.028–0.091) in model 1 and 0.04 (95% CI: 0.020–0.081) in model 2, and those for FAI were 0.94 (95% CI: 0.92–0.95) and 0.92 (95% CI: 0.90–0.92), respectively.Conclusions:Preoperative walking speed and IADL are crucial factors associated with prognosis after TAVI even after adjustment.

The Smart Life Stay (SLS) program: effects of a lifestyle intervention program in combination with health tourism and health guidance for type 2 diabetes

Matsushita M, Muramoto A, Nomura E, Eguchi Y, Kato A, Sano Y, Kabayama M, Arakawa M, Oguma Y, Yabe D, Matsunaga M, Yatsuya H, Arima H, Tsushita K

Nutrition & diabetes 10 (1), 1-9 (Nutrition and Diabetes) 10 ( 1 ) 33 - 33 2020

Research paper (scientific journal), Joint Work, ISSN 2044-4052

© 2020, The Author(s). Background: The aim of this study was to determine the effectiveness of the Smart Life Stay (SLS) program, which is an experience-oriented stayover program, in combination with health tourism and mandatory health guidance on glucose metabolism after 2 years. Methods: The participants of the SLS program (n = 792) were recruited from a database of 23 medical insurers. They underwent a mandatory health examination termed Specific Health Checkups in 2014. The participants were included if they had diabetes or were at a high risk of diabetes and if they satisfied the following inclusion criteria: (1) body mass index (BMI; kg/m2) > 25, or (2) waist circumference (WC; cm) > 85 for men and > 90 for women, or (3) hemoglobin A1c (HbA1c; %) > 5.6, or (4) fasting plasma glucose (FPG; mg/dl) > 100. Individuals who corresponded to one or more items were included as study participants. The control subjects (n = 3645) were nonparticipants of the program who were selected from the database and met the inclusion criteria. The lifestyle changes and changes in mean BMI, WC, FPG, and HbA1c in both groups from baseline to 2-year follow-up were compared by inverse probability weighting of a propensity score. Results: The percentage of people who exercised regularly increased significantly in the SLS group compared with the control group. In the SLS group, BW, BMI, and WC significantly decreased by 1.75 kg, 0.60 kg/m2, and 1.45 cm, respectively, whereas in the control group, WC, FPG, and HbA1c increased significantly by 0.38 cm, 3.37 mg/dl, and 0.12%, respectively. The comparison between groups revealed that the BW, BMI, WC, FPG, and HbA1c improved significantly in the SLS group. Conclusions: The SLS program is suggested to help improve glucose metabolism. This program could be a feasible option as a lifestyle intervention program for diabetes.

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The role and attitude of senior leaders in promoting group-based community physical activity: a qualitative study

H Komatsu, K Yagasaki, Y Oguma, Y Saito, Y Komatsu

BMC geriatrics 20 (1), 1-9 (BMC Geriatrics) 20 ( 1 ) 380 - 380 2020

Research paper (scientific journal), Joint Work

© 2020 The Author(s). Background: In the context of worldwide public health, it is very important to promote physical activity among the older people. This study explored the roles and attitudes of senior leaders in promoting group-based exercise in their local communities, specifically to determine the level and extent to which to elderly participation was encouraged. Methods: This study conducted semi-structured face-to-face in-depth interviews and employed a subsequent thematic analysis. Participants included 10 club leaders and five sub-leaders who were working at senior clubs in Fujisawa-city, Kanagawa, Japan, from July to September 2018. Results: Four themes emerged from the interview responses, including "unwavering attitude/conviction in relation to the vision,""leaders must set an example,""a search for balance in delegating responsibilities to members,"and "creating and fostering culture and environment of mutual help."Further, each participant outlined several aims, including "achieving healthy longevity for the entire local community,""having older people promote healthy activities among the older people,"and "creating a pro-health town."Conclusions: Findings indicate that policymakers, public health workers, and healthcare providers should recognize the pivotal roles that senior group leaders play in promoting healthy activities for the older people. These efforts should be strongly considered when developing policies and strategies designed to promote overall healthy longevity from a general community perspective.

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Behavioral changes and hygiene practices of older adults in Japan during the COVID-19 emergency

Y Arai, Y Oguma, Y Abe, M Takayama, A Hara, H Urushihara, ...

Department of Preventive Medicine and Public Health, Keio University 2020

Joint Work

Symposium22-3都市部における地域全体への多面的介入：ふじさわプラス・テン（神奈川県藤沢市）の取り組み

Y SAITO, Y OGUMA

体力科学 69 (1), 96 (The Japanese Society of Physical Fitness and Sports Medicine) 69 ( 1 ) 96 - 96 2020

Joint Work, ISSN 0039-906X

Symposium27-3日本体力医学会としての「脳心血管病予防に関する包括的リスク管理チャート」改定への参画

小熊祐子, 井上茂, 永富良一

Japanese Journal of Physical Fitness and Sports Medicine (The Japanese Society of Physical Fitness and Sports Medicine) 69 ( 1 ) 120 - 120 2020

ISSN 0039-906X

Influence of Temperature on Thermal Sensation and Health Condition of Student at Winter Elementary School

馬場暁子, 伊香賀俊治, 小熊祐子, 福島富士子, 富岡由美, 峰友紗, 岩崎えりか

Joint Work, ISSN 1880-3806

近年、小学校の温熱環境が児童の学習効率や健康状態に影響を及ぼすことが報告されている。また、温冷感には代謝量が影響しており、性別、年齢、活発さによる個人差が生じる可能性がある。以上より、温熱環境が児童の健康を維持するために重要な要素であり、その評価には、基礎代謝量や身体活動習慣の個人差を考慮することが必要であると考えられる。本研究では、小学校における温熱環境と温冷感・諸症状の関連について、身体活動を考慮した検討を行った。

Global Action Plan on Physical Activity 2018–2030: considering Sustainable Development Goals and Olympic legacy

OGUMA Yuko

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 28 ( 2 ) 92 - 100 2020

ISSN 1340-2560

Although physical activity has many recognized health benefits, the number of inactive persons is increasing worldwide. At the World Health Assembly in May 2018, a resolution to tackle the widespread problem of physical inactivity was made, and in June of the same year, the World Health Organization announced its Global Action Plan on Physical Activity 2018–2030 (GAPPA). To reduce physical inactivity and create a healthy and sustainable world, GAPPA set out the following four strategic objectives: "create active societies," "create active environments," "create active people," and "create active systems." These objectives are achievable through 20 policy actions, each comprising 4–6 items. These strategic objectives and policy actions do not function independently, but are interrelated and can generate co-benefits for one another through a systems-based approach, achieved through the cooperation of each field. Outcomes relate not only to health but also to many Sustainable Development Goals (SDGs). We share these aims when envisioning a long-term Olympic legacy. In the future, it will be necessary for stakeholders to gather at each level, deeply understand GAPPA objectives, and devise an appropriate system plan for execution, reevaluation, sharing, and scaling-up.

Global Action Plan on Physical Activity 2018-2030について－オリンピック・レガシー, SDGsとともに考える

OGUMA Yuko

日本健康教育学会誌 28 2020

Accepted

身体活動のすすめ今求められるシステムズアプローチ、歯科とのつながりを考える

小熊祐子, 齋藤義信

日本歯科医師会雑誌 73 293 - 304 2020

地域在住高齢者におけるポリファーマシーと抗コリン作動薬及び鎮静作用薬が身体・認知・精神に与える影響の評価 The Kawasaki Wellbeing Project

田中あさひ, 新井康通, 平田匠, 阿部由紀子, 小熊祐子, 漆原尚巳

日本老年医学会雑誌 ((一社)日本老年医学会) 56 ( 4 ) 504 - 515 2019.10

Joint Work, ISSN 0300-9173

目的:本研究の目的は高齢者におけるポリファーマシー,抗コリン作動薬及び鎮静作用薬の使用による薬剤負荷の影響を調査することである.方法:川崎市在住非介護高齢者コホートThe Kawasaki Wellbeing Projectにて2017年3月から12月までに参加した396名を対象とした.ベースライン時の薬剤情報から薬剤数を算出,抗コリン作動薬及び鎮静作用薬に該当する薬剤から対象者のDrug Burden Index(DBI)を算出し薬剤負荷とした.アウトカム指標であるADL,IADL,MMSE,J-CHS,EQ5D5Lについて多変量回帰分析を行い,使用薬剤数又はDBIとの関連性を検討した.調整には性別,年齢,疾患数,教育歴,飲酒歴,喫煙歴を用いた.結果:解析の対象となった389名において年齢の中央値は86歳,男性は48%にあたる187名であった.ポリファーマシーに該当した対象者は243名(62%)であり,DBI該当薬の使用者は142名(36.5%)となった.各アウトカム指標の結果から本集団は身体機能,QOLが高く,フレイルのリスクの低い集団であることが分かった.使用薬剤数はJ-CHS(β:0.04),EQ5D5L(-0.01)と有意に負の関連を示し,DBIスコアはEQ5D5L(-0.04)と有意に負に関連していた.結論:調査結果から本集団は一般的な高齢者と比較すると身体機能及び認知機能の高い健康な集団であることが示された.しかし,ポリファーマシー及び抗コリン作動薬及び鎮静作用薬による薬剤負荷は高齢者のフレイル,QOLの低下と関連していることが示唆された.今後はより大規模で多角的な調査項目を含めた長期間の観察を行うことが望ましい.(著者抄録)

Drug burden of polypharmacy and anticholinergic/sedative drugs and physical/cognitive/mental related outcomes of the community-dwelling elderly people: The Kawasaki well-being project

Asano Ringo, Tanaka Asahi, Arai Yasumichi, Hirata Takumi, Abe Yukiko, Oguma Yuko, Urushihara Hisashi

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 28 293 - 293 2019.08

Joint Work, ISSN 1053-8569

食育に役立つ配膳を基本としたたまごの大きさを基準に摂取量を回答する食事調査票「たまごの大きさで数える食事チェックシート-簡単版-」の開発

鈴木亜夕帆, 小熊祐子, 東宏一郎, 渡邊智子

千葉県立保健医療大学紀要 (千葉県立保健医療大学) 10 ( 1 ) 97 - 105 2019.03

Joint Work, ISSN 1884-9326

摂取量をたまごの大きさで回答する「たまごの大きさで数える食事チェックシート」の簡単版を開発した.質問用紙は,両面カラー印刷,仕上がりA4版サイズ,二つ折,全4ページの様式とした.質問用紙は,表紙,回答方法の説明,食事内容回答,生活習慣回答ページの4つの構成とした.食事内容回答ページは,見開きページにして一覧で見ることができるようにした.個人結果票は,カラー印刷,A4版サイズ,1枚とし,食事配膳区分を中心とした結果表示とした.摂取量は,たまごの大きさでどのくらいか回答できるため,摂取重量が不明でも本人が回答しやすいものであること,食事配膳区分でのみ回答をするため,質問の項目が少なくなり,食事に興味があまりない方への食事調査で回答のハードルを下げること,食育イベント等で来場した方へ短時間で結果を配布することが可能になると考えられる.妥当性と再現性は,現在解析中である.(著者抄録)

Drug burden of polypharmacy and anticholinergic/sedative drugs and physical/cognitive/mental related outcomes of the community-dwelling elderly people: The Kawasaki well-being …

R Asano, A Tanaka, Y Arai, T Hirata, Y Abe, Y Oguma, H Urushihara

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 28, 293-293 2019

Joint Work

Classification of body components and activity patterns by data mining of health care data.

Shunichi Nomura, Michiko Watanabe, Yuko Oguma

Oukan (Transdisciplinary Federation of Science and Technology) 13 ( 1 ) 15 - 22 2019

Research paper (scientific journal), Joint Work, ISSN 1881-7610

Healthcare data is rapidly increasing as healthcare smart devices are developed. However, statistical analysis of healthcare big data is difficult due to heterogeneity in data quality and missing data. For such data, data mining methods such as clustering and dimension reduction may be useful as their preliminary analysis. In this paper, we show two illustrative applications; one is a principal component analysis of body composition data and the other is a latent topic analysis of hourly step-count dataset recorded by physical activity monitors. From those analyses, we proposed independent indices of body size and hidden obesity and extracted some diurnal patterns in ambulatory activities.

Effects of polypharmacy and anticholinergic/sedative drugs on the physical/cognitive/mental related outcomes of community-dwelling elderly people: The Kawasaki Wellbeing Project

A Tanaka, Y Arai, T Hirata, Y Abe, Y Oguma, H Urushihara

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 56 (4), 504-515 (The Japan Geriatrics Society) 56 ( 4 ) 504 - 515 2019

ISSN 03009173

Aim: To assess the burdens of polypharmacy and the drug burden index in community-dwelling elder people.Methods: The survey was conducted on 396 participants who participated in The Kawasaki Wellbeing Project from March to December 2017. We investigated the associations between the drug burden and the physical/cognitive/mental outcomes. The drug burden was determined by calculating the number of medications and the drug burden index (DBI) based on the use of anticholinergic and sedative drugs. A multivariate regression analysis was conducted for the outcome measures ADL, IADL, MMSE, J-CHS, and EQ5D5L after adjusting for the sex, age, number of diseases, education level, smoking history, and alcohol history.Results: A total of 389 subjects were analyzed, the mean age of the population was 86 years old, and 187 people (48%) were male. Polypharmacy was reported in 243 people (62%), and DBI exposure was reported for 142 people (36.5%). We found that this population was physically healthy, with a median ADL of 100, and had high quality of life, with a median EQ5D5L of 0.895. Polypharmacy was found to be related to the J-CHS (β: 0.04) and EQ5D5L (−0.01). The DBI was also related to the EQ5D5L (−0.04).Conclusion: These results showed that even though this population was healthier than the general Japanese elderly population, the drug burden of polypharmacy and high dosages of anticholinergic/sedative drugs exerted significant negative effects on frailty and the quality of life. Additional research should be conducted to investigate the long-term effects of polypharmacy and anticholinergic/sedative drugs on elderly people.

健康長寿社会における身体活動と健康ー「ふじさわプラス・テン」の取り組みを通してー

小熊祐子, 齋藤義信

予防医学 60 21 - 25 2019

健康長寿社会における健康支援-アクティブシニアを目指して健康長寿社会における身体活動と健康-「ふじさわプラス・テン」の取り組みを通して

Y OGUMA, Y SAITO

予防医学, 21-25 2019

Population-based approaches to promote physical activity: the Fujisawa +10 project

SAITO Yoshinobu, TAJIMA Takayuki, SHIBA Chisato, OGUMA Yuko

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 27 ( 1 ) 71 - 81 2019

Accepted, ISSN 1340-2560

Objective: We introduced the physical activity promotion project "Fujisawa +10" and aimed to provide reference information regarding evaluation methods and research findings translating to health education and promotion.Contents: We conducted a community-wide intervention to promote physical activity based on the Japanese physical activity guideline (Active Guide) in cooperation with Fujisawa city. The intervention's key message was "Plus Ten (+10: be active for 10 more minutes than now). We implemented this project in 4 districts for 2 years from 2013, and evaluated its pre- and post-implementation effects using population-based surveys (Phase 1). The RE-AIM evaluation revealed a low degree of reaching residents and improved active guide knowledge, but unchanged physical activity levels. From 2015, we applied it to all districts, considering the Phase 1 results (Phase 2). We aimed to improve the degree of reach and focused on group exercise interventions intended to spread to residents. Elderly individuals who performed the group exercise showed improved physical fitness one year later and consistent physical activity and cognitive function. Then, the number of participants increased by 21% in a year. We extracted features of rules, roles, and tools as important aspects of smooth group activities, and created manuals. These findings are still utilized in Fujisawa city health promotion.Conclusion: This project involved RE-AIM evaluations and strategy improvement. Our findings were translated into the city's policy and scaled up. In Japan, in addition to increases in the practices, it is necessary to further disseminate and implement evaluation frameworks such as the RE-AIM model.

Physical activity, exercise, and health promotion for cancer survivors

OGUMA Yuko, SAITO Yoshinobu, TAJIMA Takayuki

Japanese Journal of Health Education and Promotion (JAPANESE SOCIETY OF HEALTH EDUCATION AND PROMOTION) 27 ( 1 ) 109 - 114 2019

ISSN 1340-2560

Introduction: Physical activity is known to reduce the risk of cancer morbidity and mortality, and to give the health benefits for cancer survivors. For example, after receiving cancer diagnosis, appropriate physical activity can improve prognosis afterwards. Evidence is available to show the risk of cancer-related mortality falls to 50% in the group that continues exercise after a cancer diagnosis. Previous interventional studies also show improvement in physical fitness, quality of life, mood, reduced anxiety and depression/fatigue, an effect on body image/body composition, and an improvement in biomarkers related to cancer risk and outcome.Current status of physical activities: Based on this evidence, the American Cancer Society/American College of Sports Medicine recommends that cancer survivors engage in 150 minutes per week of moderate-intensity aerobic physical activity (or 75 minutes/week of vigorous-intensity aerobic physical activity) and two strength training sessions per week, as well as decreased sedentary time. However, <30% of persons diagnosed with cancer are reported to meet the recommended levels. To maintain high physical activity in real life settings, a feasible strategy in society should be established.Toward Social Implementation: In the 2017 Clinical Practice Guidelines (Canada), evidence supports the promotion of exercise in a group or supervised settings. For sustainable engagement in physical activity, it is important to be able to exercise under guidance and to promote physical activities in daily life, depending on the situation.

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運動開始前の健康スクリーニング～誰が何をするのか～

小熊祐子

日本臨床運動療法学会誌 20 27 - 31 2019

健康長寿社会における身体活動と健康－「ふじさわプラス・テン」の取り組みを通して－

小熊祐子, 齋藤義信

予防医学 60 21 - 25 2019

脳心血管病予防に関する包括的リスク管理チャート2019年版について

小熊祐子, 井上茂, 永富良一

日内会誌 108 ( 5 ) 1024 - 1070 2019

Prevalence of Metabolic Syndrome and Lifestyle Characteristics by Business Type among Japanese Workers in Small- and Medium-sized Enterprises

Hozawa, H., Takeuchi, A. and Oguma, Y.

Keio J Med (Keio Journal of Medicine) 68 ( 3 ) 54 - 67 2018.12

Joint Work, ISSN 0022-9717

This cross-sectional study investigated the associations of business type with the prevalence of metabolic syndrome (MetS) and lifestyle characteristics among workers in small- and medium-sized enterprises. In total, data from 167,736 workers (114,746 men and 52,990 women) who participated in health checkups in 2013 were analyzed using multilevel logistic regression models. The odds ratios (ORs) of having MetS, defined based on the criteria of the joint interim statement, were significantly higher in employees of transportation businesses (reference OR =1) than in other business types among men (OR: 0.67-0.85) and similar result was observed among women (OR: 0.70-0.88). The prevalence of a smoking habit was significantly higher in transportation workers than in employees of other businesses for both men and women. Furthermore, male transportation workers were more likely to skip breakfast, engage in <1 h/day of walking, walk at a slower speed, and eat dinner just before going to bed. Female transportation workers were more likely to have gained 10 kg since the age of 20 years. In conclusion, the prevalence of MetS was higher in transportation workers than in workers from other businesses; the associated risk factors may also vary by sex. To effectively promote public health, the labor environment, such as the business type, should be considered.

Elevated creatine kinase and lactic acid dehydrogenase and decreased osteocalcin and uncarboxylated osteocalcin are associated with bone stress injuries in young female athletes

T Miyamoto, Y Oguma, Y Sato, T Kobayashi, E Ito, M Tani, K Miyamoto, ...

Scientific reports 8 (1), 18019 (Scientific Reports) 8 ( 1 ) 18019 - 18019 2018.12

Joint Work, ISSN 2045-2322

© 2018, The Author(s). Stress fractures are a limitation for athletes not only in sports performance but in activities of daily living. Thus, preventing them is crucial. In female athletes, a triad of symptoms including low energy availability, functional hypothalamic amenorrhea and osteoporosis are considered risk factors for stress injuries, but biomarkers predictive of these outcomes are not available. Here, we evaluated 56 female university athletes and found that 13 had a history of stress bone injuries. Logistic regression analysis demonstrated that dysmenorrhea including amenorrhea, but not reduced food intake or body weight loss, was significantly associated with stress injuries. When we subdivided subjects into stress fracture and non-fracture groups, we found that serum levels of creatine kinase (CK) and lactic acid dehydrogenase (LDH) were significantly higher in the fracture group, while osteocalcin and uncarboxylated osteocalcin (ucOC), which are bone forming parameters, significantly decreased. Low vitamin D levels are associated with stress fractures, but serum vitamin D levels were higher in fracture compared to non-fracture subjects. We followed up 32 subjects for

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Relationship of objectively measured physical activity and physical function of community-dwelling very old in Kawasaki, Japan: baseline assessment of Kawasaki well-being prospective cohort study

Oguma Yuko, Tajima Takayuki, Saito Yoshinobu, Fukui Shogo, Kibayashi Yayoi, Yoshida Natsuko, Ishida Hiroyuki, Hirata Takumi, Abe Yukiko, Arai Yasumichi

JOURNAL OF PHYSICAL ACTIVITY & HEALTH 15 ( 10 ) S34 - S34 2018.10

ISSN 1543-3080

Physical Activity Among Postoperative Esophageal Cancer Patients

Ichijo, Y., Takeda, Y., Oguma, Y., Kitagawa, Y., Takeuchi, H. and Doorenbos, A. Z.

Cancer Nurs (Cancer nursing) 42 ( 6 ) 501 - 508 2018.09

Joint Work, ISSN 0162-220X

BACKGROUND: Previous literature has reported that regular physical activity enhances health-related quality of life for cancer patients. However, there is a lack of studies that focus on physical activity among postoperative esophageal cancer patients. OBJECTIVE: The aims of this study were to (1) describe the prevalence of physical activity among postoperative esophageal cancer patients, (2) explore variables related to physical activity (demographics, nutrition, dysphagia, and health-related qualify of life), and (3) examine potential reasons for inactivity among participants who scored low using case studies. METHODS: In this cross-sectional design, physical activity was evaluated by the Japanese version of the International Physical Activity Questionnaire. Variables were analyzed using Spearman rank correlation coefficients, Mann-Whitney U tests, or Fisher exact tests. RESULTS: Fifty-eight patients participated in this study; 79% met the recommended physical activity guidelines. Present occupational status and past leisure-time physical activity behavior before the cancer diagnosis were related to current leisure-time physical activity and meeting the guidelines postoperatively. Participants who scored 0 (little or no activity) in the questionnaire also scored low in health-related quality of life. CONCLUSIONS: Participants performed especially well in physical activity related to leisure time and transportation. Positive reinforcement is needed for patients who perform adequate levels of physical activity, and reviewing the benefits of regular physical activity is encouraged for all. IMPLICATIONS FOR PRACTICE: Occupational status and past leisure-time physical activity before diagnosis can be indicators for promoting physical activity among postoperative esophageal cancer patients. Inactive participants should be supported to promote both physical activity and health-related qualify of life.

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高齢者地域コミュニティのグループ運動継続に関わる特徴

柴, 知里, 齋藤, 義信, 今村, 晴彦, 田中, あゆみ, 土村, 里佳 and 小熊, 祐子

日本健康教育学会誌 (日本健康教育学会) 26 ( 2 ) 144 - 154 2018.05

Joint Work, ISSN 1340-2560

目的:高齢者地域コミュニティのグループ運動継続に関わる特徴を把握する。事業/活動内容:対象は藤沢市で実施中の身体活動促進のための地域介入研究に参加し、6ヵ月間グループ運動を継続している8グループ(120名)である。研究参加時、6ヵ月後時点で質問紙調査、体力測定、認知機能評価を行った。運動プログラムやモニタリングツールを提供し、定期的なフォローアップや交流会、グループワークを行った。事業/活動評価:(1)リーダーの特徴と協力者の有無および協力の主体性で8グループを4群に分類し、質問紙による身体活動量、精神的健康、地域とのつながり、個人要因を比較した。(2)グループ向け質問紙、交流会、グループワークの質的情報から、グループの特徴を比較した。結果を統合してコミュニティづくりに重要なルール(自生した規則や制度)、ロール(自発的な役割)、ツール(道具や資源)の観点からグループの特徴を把握した。活動基盤となるルールは、全グループ共通のル

Maintenance Of Physical Activity Level And Dissemination Of "Plus Ten" Message In Community-based Group Exercise

Saito Yoshinobu, Oguma Yuko, Tajima Takayuki, Tanaka Ayumi, Kibayashi Yayoi, Shiba Chisato, Miyachi Motohiko, Takebayashi Toru

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 50 ( 5 ) 62 - 63 2018.05

Joint Work, ISSN 0195-9131

地域在住高齢者における個人レベルのソーシャル・キャピタルと身体活動との関連　横断研究

齋藤, 義信, 小熊, 祐子, 田島, 敬之, 加藤, 梨里, 木林, 弥生, 宮地, 元彦 and 武林, 亨

体力科学 ((一社)日本体力医学会) 67 ( 2 ) 177 - 185 2018.04

Joint Work, ISSN 0039-906X

「健康と生活に関するアンケート」に回答した高齢者534名(男性260名、女性274名、68〜78歳)を対象とした。男女の比較で有意差を認めた人口統計学的属性・社会経済的属性は、居住形態(女性の独居割合が高い)、BMI(男性が高い)、身体活動の制限(女性の医師または足腰の痛みによる制限がある割合が高い)、教育歴(男性の大学卒以上の割合が高い)、収入がある仕事(男性の仕事をもつ割合が高い)であった。ソーシャル・キャピタル(SC)では地域の人とのかかわりと他世代との交流において有意な男女差(女性のSCが高い)を認めた。SCが低いと想定される回答を基準とした解析で、男性では、地域の支え合い:支え合うと思う、地域の人とのかかわり:立ち話をする人がいる、相談しあえる人がいる、他世代との交流:まあまあある、とてもあるにおいて有意な正の関連を認めた。トレンド検定では、有意な量反応関係を認めた。女性では、地域の人とのかかわり:相談しあえる人がいる、地域組織活動へ

Awareness of physical activity promotion, physical activity, and sedentary behavior in elderly Japanese

Tajima, Takayuki, Saito, Yoshinobu, Kato, Riri, Kibayashi, Yayoi, Miyachi, Motohiko, Lee, I-Min and Oguma, Yuko

The Journal of Physical Fitness and Sports Medicine (一般社団法人日本体力医学会) 7 ( 2 ) 113 - 119 2018.03

Joint Work, ISSN 2186-8131

本研究の目的は、日本人高齢者を対象に「アクティガイド」や「プラス・テン」などの身体活動プロモーションの認知と身体活動時間、座位行動時間の関連について検討することである。我々は2013年より神奈川県藤沢市において身体活動促進のためのコミュニティワイドキャンペーンを実施している。この取り組みの成果評価及び2015年度以降に行う全市的な介入の事前評価の位置づけで、2015年6月に20歳以上の藤沢市民3,000名を無作為抽出して質問紙調査を実施した。本研究ではその質問紙調査を用い、65歳以上の高齢者874名を対象者とした。このうち550名から返答があり、データに欠損のない373名を解析に用いた。48%(179/373名)が「アクティブガイド」や「プラス・テン」などの身体活動プロモーションを認知していた。身体活動時間(運動を行っている時間と歩行またはそれと同等以上の強度の生活活動を行っている時間の総和)の中央値は100分/日、座位行動時間の中央値は300分/日であった。身体活動プロモーションの認知と身体活動時間には有意な関連はみられなかったが(Odds Ratio(OR) for≧100minutes/day)=1.02,95% Confidence Interval(CI)=0.65-1.62)、座位行動時間との間には有意な関連性がみられた(OR for<300minutes/day)=1.60,95%CI=1.01-2.53)。高齢者において、強度を問わず日に40分以上の身体活動をすすめるアクティブガイドや、皆に今より10分多く体を動かすことをすすめるプラス・テンというメッセージの認知をすることは、高齢者において座位行動を減少させる可能性が示唆された。(著者抄録)

Association of high individual-level of social capital with increased physical activity among community-dwelling elderly men and women: A cross-sectional study

Y Saito, Y Oguma, T Tajima, R Kato, Y Kibayashi, M Miyachi, ...

Japanese Journal of Physical Fitness and Sports Medicine 67 (2), 177-185 (Japanese Journal of Physical Fitness and Sports Medicine) 67 ( 2 ) 177 - 185 2018

Research paper (scientific journal), Joint Work, ISSN 0039906X

We aimed to evaluate the associations of individual-level social capital (SC) and physical activity (PA) among Japanese elderly men and women. Individuals aged 65 or above were selected via population-based random sampling of 3000 adults, aged 20 years or above and living in Fujisawa city, who were asked to complete self-administered questionnaires. The sample consisted of 260 men [median (25-75% tile) age 73 (68-78) yrs] and 274 women [73 (68-78) yrs]. The daily duration of PA, SC [e.g., norms of reciprocity (mutual support in the community), social networks (relationship with community people, exchange with other generations), social participation (participation in community organization activities)], socio-economic status [educational attainment, work with income, perceived household economic status], and demographic characteristics [sex, age, living arrangements, BMI, physical limitations] were assessed. Multivariate logistic regression analyses were used to calculate odds ratios (OR) for associations of SC with PA, stratified by sex. High level of mutual support in the community, relationship with community people, and exchange with other generations were associated with longe

Effects of replacing sedentary behavior with different intensities of physical activity on physical function among community-dwelling elderly: A cross-sectional study

T Tajima, Y Saito, Y Kibayashi, Y Oguma

JOURNAL OF PHYSICAL ACTIVITY & HEALTH 15 (10), S233-S234 (International Society of Physical Activity and Health) 15 ( 10 ) S233 - S234 2018

Joint Work, ISSN 1543-3080

Maintenance Of Physical Activity Level And Dissemination Of “Plus Ten” Message In Community-based Group Exercise: 307 Board# 148 May 30 930 AM-1100 AM

Y Saito, Y Oguma, T Tajima, A Tanaka, Y Kibayashi, C Shiba, M Miyachi, ...

Medicine & Science in Sports & Exercise 50 (5S), 62-63 2018

Joint Work

Relationship of objectively measured physical activity and physical function of community-dwelling very old in Kawasaki, Japan: baseline assessment of Kawasaki well-being …

Y Oguma, T Tajima, Y Saito, S Fukui, Y Kibayashi, N Yoshida, H Ishida, ...

JOURNAL OF PHYSICAL ACTIVITY & HEALTH 15 (10), S34-S34 15 ( 10 ) S34 - S34 2018

Joint Work, ISSN 1543-3080

RE-AIM evaluation of a community-wide physical activity intervention based on the Japanese guideline in adults: the Fujisawa+ 10 project

Y Saito, A Tanaka, T Tajima, Y Kibayashi, M Miyachi, Y Oguma

JOURNAL OF PHYSICAL ACTIVITY & HEALTH 15 (10), S155-S156 (International Society of Physical Activity and Health) 15 ( 10 ) S155 - S156 2018

Joint Work, ISSN 1543-3080

Maintenance Of Physical Activity Level And Dissemination Of “Plus Ten” Message In Community-based Group Exercise: 307 Board# 148 May 30 9: 30 AM-11: 00 AM

Y Saito, Y Oguma, T Tajima, A Tanaka, Y Kibayashi, C Shiba, M Miyachi, ...

Medicine & Science in Sports & Exercise 50 (5S), 62-63 2018

Community-wide physical activity intervention based on the Japanese physical activity guidelines for adults: A non-randomized controlled trial

Saito, Y., Oguma, Y., Tanaka, A., Kamada, M., Inoue, S., Inaji, J., Kobori, Y., Tajima, T., Kato, R., Kibayashi, Y., Narumi, Y., Takeuchi, A., Miyachi, M., Lee, I. M. and Takebayashi, T.

Prev Med (Preventive Medicine) 107 61 - 68 2017.11

Research paper (scientific journal), Joint Work, ISSN 0091-7435

Very few community intervention studies that promote physical activity (PA) using guidelines and its dissemination and implementation have been conducted. Consequently, we evaluated the effectiveness of a community-wide intervention (CWI) of PA with adults based on the Japanese guidelines for promoting PA. This was a non-randomized controlled trial, with four administrative districts in Fujisawa city assigned to the intervention group and nine to the control group. The CWI, conducted from 2013 to 2015, comprised information dissemination, education, and community support. The primary outcome was change in PA participation. Secondary outcomes were CWI awareness and PA guideline knowledge. Outcomes were assessed using questionnaires distributed to two independent, random samples of 3000 community-based adults (aged >/=20years). Two separate samples-1230 adults at baseline and 1393 at the two-year follow-up-responded to the survey. The median time spent in PA did not differ between intervention and control groups after adjusting for potential confounders (adjusted difference between groups=-0.02min/day [95% confidence interval (CI): -0.11, 0.10]). However, intervention group participants were more aware of the CWI (33.8%) than were control group participants (25.2%) at the two-year follow-up (odds ratio=1.44 [95% CI: 1.06, 1.95]). A significant difference was also observed in participants' PA guideline knowledge (adjusted difference between groups=0.82% [95% CI: 0.33, 1.31]). Although significant differences in awareness and knowledge were observed between groups, this CWI did not change PA levels over two years. Future studies should investigate the long-term effects of CWIs beyond two years. TRIAL REGISTRATION NUMBER: UMIN-CTR UMIN000018389.

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Regular group exercise contributes to balanced health in older adults in Japan: a qualitative study

Komatsu, H., Yagasaki, K., Saito, Y. and Oguma, Y.

BMC Geriatr (BIOMED CENTRAL LTD) 17 ( 1 ) 190 2017.08

ISSN 1471-2318

BACKGROUND: While community-wide interventions to promote physical activity have been encouraged in older adults, evidence of their effectiveness remains limited. We conducted a qualitative study among older adults participating in regular group exercise to understand their perceptions of the physical, mental, and social changes they underwent as a result of the physical activity. METHODS: We conducted a qualitative study with purposeful sampling to explore the experiences of older adults who participated in regular group exercise as part of a community-wide physical activity intervention. Four focus group interviews were conducted between April and June of 2016 at community halls in Fujisawa City. The participants in the focus group interviews were 26 older adults with a mean age of 74.69 years (range: 66-86). The interviews were analysed using the constant comparative method in the grounded theory approach. We used qualitative research software NVivo10(R) to track the coding and manage the data. RESULTS: The finding 'regular group exercise contributes to balanced health in older adults' emerged as an overarching theme with seven categories (regular group exercise, functional health, active mind, enjoyment, social connectedness, mutual support, and expanding communities). Although the participants perceived that they were aging physically and cognitively, the regular group exercise helped them to improve or maintain their functional health and enjoy their lives. They felt socially connected and experienced a sense of security in the community through caring for others and supporting each other. As the older adults began to seek value beyond individuals, they gradually expanded their communities beyond geographical and generational boundaries. CONCLUSIONS: The participants achieved balanced health in the physical, mental, and social domains through regular group exercise as part of a community-wide physical activity intervention and contributed to expanding communities through social connectedness and mutual support. Health promotion through physical activity is being increasingly emphasized. The study results can help to develop effective physical activity programs for older adults in the community.

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Effects of stretching exercise with a stretching-support cushion on flexibility in over middle-aged women

Osawa, Y. and Oguma, Y.

Gazzetta Medica Italiana Archivio Per Le Scienze Mediche (Edizioni Minerva Medica) 176 ( 4 ) 180 - 187 2017.04

ISSN 0393-3660

BACKGROUND: Recently, stretching-support cushions (SC) have become available for use during stretching exercises in the seated position. However, the effects of a SC consisting of a 20-deg posterior support cushion on flexibility-related outcomes when combined with stretching exercises are not well understood. Here, a randomized controlled trial involving 32 healthy over-middle aged women (56.9 +/- 7.4 years old) was performed to investigate the additional effects of stretching program with SC on the flexibility compared with the identical program without SC. METHODS: The participants were randomly assigned to stretching exercises with SC (EX-SC, N.= 16) or the identical stretching exercises without SC (EX, N.= 16). We investigated the additional effects of using SC on flexibility by measuring the degree of hip abduction, pelvic tilt, and maximum forward reaching distance, sit and reach test, and passive torque of right hamstrings during passive knee extension before and after the single session of program. RESULTLTS: After performing the stretching exercises with (EX-SC group) and without (EX group) the SC, significantly change in pelvic tilt in the seated straddle split position was observed in the EX-SC group (21.0 +/- 28.9 to 33.1 +/- 24.0 deg) compared with the EX group (22.1 +/- 20.8 to 26.9 +/- 22.8 deg; P<0.05). For all other flexibility-related parameters, only the time effects were significant (P<0.05). CONCLUSIONS: Taken together, the present results suggest that use of a SC is beneficial for performing stretching exercises when seated to avoid a `rounded-back position'.

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Validation of Questionnaire-Assessed Physical Activity in Comparison With Objective Measures Using Accelerometers and Physical Performance Measures Among Community-Dwelling Adults Aged >/=85 Years in Tokyo, Japan

Oguma, Y., Osawa, Y., Takayama, M., Abe, Y., Tanaka, S., Lee, I. M. and Arai, Y.

J Phys Act Health (HUMAN KINETICS PUBL INC) 14 ( 4 ) 245 - 252 2017.04

ISSN 1543-3080

BACKGROUND: To date, there is no physical activity (PA) questionnaire with convergent and construct validity for the oldest-old. The aim of the current study was to investigate the validity of questionnaire-assessed PA in comparison with objective measures determined by uniaxial and triaxial accelerometers and physical performance measures in the oldest-old. METHODS: Participants were 155 elderly (mean age 90 years) who were examined at the university and agreed to wear an accelerometer for 7 days in the 3-year-follow-up survey of the Tokyo Oldest-Old Survey of Total Health. Fifty-nine participants wore a uniaxial and triaxial accelerometer simultaneously. Self-rated walking, exercise, and household PA were measured using a modified Zutphen PA Questionnaire (PAQ). Several physical performance tests were done, and the associations among PAQ, accelerometer-assessed PA, and physical performances were compared by Spearman's correlation coefficients. RESULTS: Significant, low to moderate correlations between PA measures were seen on questionnaire and accelerometer assessments (rho = 0.19 to 0.34). Questionnaireassessed PA measure were correlated with a range of lower extremity performance (rho = 0.21 to 0.29). CONCLUSIONS: This PAQ demonstrated convergent and construct validity. Our findings suggest that the PAQ can reasonably be used in this oldest-old population to rank their PA level.

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Relationships of Muscle Echo Intensity with Walking Ability and Physical Activity in the Very Old Population

Osawa, Y., Arai, Y., Oguma, Y., Hirata, T., Abe, Y., Azuma, K., Takayama, M. and Hirose, N.

Journal of Aging and Physical Activity (HUMAN KINETICS PUBL INC) 25 ( 2 ) 189 - 195 2017.04

ISSN 1063-8652

This study investigated the relationships between muscle echo intensity (EI), physical activity (PA), and functional mobility in 108 Japanese (88-92 years). We measured EI and muscle thickness (MT) at the midpoint of the anterior superior iliac spine and patella using B-mode ultrasound. Light and moderate-to-vigorous PA (LPA and MVPA) were assessed with a triaxial accelerometer. The timed up and go (TUG) test was used to measure for functional mobility. EI, but not MT, was significantly associated with both TUG scores (beta = 0.17, p =.047) and MVPA (beta = -0.31, p =.01) when adjusted by potential confounders. However, association between EI and TUG disappeared after adjusted for MVPA. Meanwhile, MVPA was significantly associated with TUG scores independent of EI (beta = -0.35, p <.001). Although EI of anterior thigh muscles might be a weaker predictor of functional morbidity than MVPA, it is a noninvasive and practical approach for assessing muscle quality in the very old.

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Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

Fujii, C., Kawai, T., Azuma, K., Oguma, Y., Katsukawa, F., Hirose, H., Tanaka, K., Meguro, S., Matsumoto, H. and Itoh, H.

J Diabetes Res (HINDAWI LTD) 2017 1567467 2017

ISSN 2314-6745

Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r = -0.411, p < 0.0001), fasting glucose (r = -0.330, p < 0.0001), HbA1c (r = -0.231, p = 0.0146), and systolic blood pressure (r = -0.224, p = 0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r = -0.416, p < 0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. Conclusion. We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.

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Relationship between Social Capital and Cognitive Functions among Community-Based Elderly

Takechi, Sayuri, Yoshimura, Kimio, Oguma, Yuko, Saito, Yoshinobu and Mimura, Masaru

Advances in Alzheimer's Disease 06 ( 02 ) 45 - 51 2017

ISSN 2169-2459

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運動開始のメディカルチェックについて考える―地域での身体活動促進を念頭に

小熊祐子

慶應義塾大学スポーツ医学研究センター紀要2016 19 - 23 2017

地域在住85歳以上高齢者における身体活動量の促進・阻害因子 TOOTH study

大澤, 祐介, 新井, 康通, 小熊, 小熊祐子, 高山, 美智代, 平田, 匠, 阿部, 由紀子, 広瀬, 信義

日本老年医学会雑誌 53 ( 4 ) 469 - 470 2016.10

ISSN 0300-9173

身体活動量増加のためのコミュニティ・ワイド・キャンペーンクラスター・非ランダム化試験(「ふじさわプラス・テン」プロジェクト) 研究プロトコル

齋藤, 義信, 小熊, 祐子, 田中, あゆみ, 鎌田, 真光, 井上, 茂, 稲次, 潤子, 小堀, 悦孝

運動疫学研究: Research in Exercise Epidemiology 18 ( 2 ) 88 - 98 2016.09

ISSN 1347-5827

背景:身体活動が健康増進に有益なことは明らかになっているが,非活動的な者は多い。そのため地域(ポピュレーション)レベルの身体活動促進に関する知見の蓄積は重要である。近年,コミュニティ・ワイド・キャンペーン(Community-Wide Campaign;CWC)のような複合的なポピュレーション介入が推奨されているが,エビデンスは十分でない。厚生労働省では,健康づくりのための身体活動指針(アクティブガイド)を発表し,身体活動促進の普及啓発を行っている。今後,地域でどのようにアクティブガイドを活用できるかを検討し,知見を蓄積していくことが重要である。目的:本研究はアクティブガイドを活用したCWCが,ポピュレーションレベルで住民の身体活動量増加につながるかを明らかにすることを目的とした。方法:研究デザインは神奈川県藤沢市の全13地区を非ランダムに介入4地区,対照9地区に割り付けるクラスター・非ランダム化試験である。介入期間は2年間(2013年7月〜2015年6月)とし,対照地区は従来の保健施策を行った。介入は60歳以上の高齢者を主ターゲットとし,(1)情報提供,(2)教育機会,(3)住民間のサポート・コミュニティ形成促進,の要素から構成した。主要評価項目は質問紙で求めた身体活動時間であり,介入前後に藤沢市が20歳以上の住民を無作為抽出して行う質問紙調査の結果を用いて比較する。副次評価項目はアクティブガイドの認知・知識のある者の割合の変化,身体活動の意図がある者の割合の変化等である。介入全体の評価は,RE-AIMモデルを適用する。(著者抄録)

成人非ホジキンリンパ腫サバイバーにおける身体活動と生活の質との関連性

荒武, 喜子, 小松, 浩子, 小熊, 祐子, 石澤, 丈, 森, 毅彦, 岡本, 真一郎

理学療法科学 (The Society of Physical Therapy Science) 31 ( 4 ) 551 - 558 2016.08

ISSN 1341-1667

[目的]日本の中悪性度成人非ホジキンリンパ腫(NHL)サバイバーの身体活動量(PA)と健康関連QOL(HRQOL)との関連性を明らかにすることを目的とした。[対象と方法]都内1大学病院通院中のNHL患者(診断後6ヵ月-8年の者)100名(年齢中央値65.0歳)とした。自己記入式質問紙法により得られるPAとHRQOLの関連を重回帰分析にて解析した。[結果]PAは多いほど身体面のHRQOLも有意に高くなるが、精神面のHRQOLに対する寄与は示されなかった。[結語]身体活動の取組みのHRQOL促進に対する有用性が示唆される。(著者抄録)

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血中脂肪酸分画と体組成、経口糖負荷試験(OGTT)時の糖代謝指標との関連

河合, 俊英, 東, 宏一郎, 藤井, 千華子, 小熊, 祐子, 松本, 秀男, 伊藤, 裕

日本内分泌学会雑誌 92 ( 1 ) 245 2016.04

ISSN 0029-0661

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

Fukai, K., Harada, S., Iida, M., Kurihara, A., Takeuchi, A., Kuwabara, K., Sugiyama, D., Okamura, T., Akiyama, M., Nishiwaki, Y., Oguma, Y., Suzuki, A., Suzuki, C., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M. and Takebayashi, T.

PLoS One (PUBLIC LIBRARY SCIENCE) 11 ( 10 ) e0164877 2016

ISSN 1932-6203

OBJECTIVE: Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabolites using a targeted metabolomics approach in a population-based study. METHODS: A total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the baseline survey of a cohort study. Information on daily total physical activity, classified into four levels by quartile of metabolic equivalent scores, and sedentary behavior, defined as hours of sitting per day, was collected through a self-administered questionnaire. Plasma metabolite concentrations were quantified by capillary electrophoresis mass spectrometry method. We performed linear regression analysis models with multivariable adjustment and corrected p-values for multiple testing in the original population (n = 808). The robustness of the results was confirmed by replication analysis in a separate population (n = 385) created by random allocation. RESULTS: Higher levels of total physical activity were associated with various metabolite concentrations, including lower concentrations of amino acids and their derivatives, and higher concentrations of pipecolate (FDR p <0.05 in original population). The findings persisted after adjustment for age, body mass index, smoking, alcohol intake, and energy intake. Isoleucine, leucine, valine, 4-methyl-2-oxoisopentanoate, 2-oxoisopentanoate, alanine, and proline concentrations were lower with a shorter sitting time. CONCLUSIONS: Physical activity is related to various plasma metabolites, including known biomarkers for future insulin resistance or type 2 diabetes. These metabolites might potentially play a key role in the protective effects of higher physical activity and/or less sedentary behavior on non-communicable diseases.

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Evaluation of a Community-based Health Promotion Program with Online Off-line Combination: The Effect of an Online Diet Record System on Self-rated Achievement

Miyagawa, Shoko, Oguma, Yuko and Ohgi, Yuji

Procedia Computer Science (ELSEVIER SCIENCE BV) 100 768 - 775 2016

ISSN 18770509

The aim of this study is to clarify the effect of e-health community health promotion program, which consists of both online diet record system and off-line health activities. 49 participants are surveyed concerning self-rated sense of understanding and sense of control about calorie intake, nutrition balance, and physical activity along with basic information, internet usage and lifestyle habit are surveyed during 2009-2011. Self-rated sense of achievement regarding dietary understanding and dietary sense of control significantly increased in a group that utilized the online diet record system. Further analysis shows that the usage of the diet record system affects the self-rated sense of achievement while neither age, sex, answers of the preliminary questionnaire nor session participation had any effect. (C) 2016 The Authors. Published by Elsevier B.V.

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Significance evaluation of Anti-Aging QOL Common Questionnaire.

Oguma, Y, Iida, K, Yonei, Y and Satoh, T

Glycative Stress Research 3(3): 177-185, 2016. (Society for Glycation Stress Research, Glycation Stress Research Center, Doshisha University) 3 ( 3 ) 177 - 185 2016

ISSN 2188-3602

Relationships between Anterior Thigh Muscle Echo Intensity and Physical Activity and Functional Mobility in a Very Old Population.

Osawa, Yusuke, Arai, Yasumichi, Oguma, Yuko, T, Hirata, Y, Abe, Azuma, Koichiro, Takayama, Michiyo and N, Hirose

J Aging Phys Act. 6 1 - 25 2016

【トップアスリートの育成支援と健康寿命延伸をめざす生涯スポーツ】身体活動と健康「プラス・テン」から生涯スポーツへ

木林弥生, 小熊祐子

保健の科学 (杏林書院) 57 ( 12 ) 824 - 829 2015.12

ISSN 0018-3342

Exercise Workload of the “Fujisawa +10 Exercise”　Program in Older Women

Yusuke Osawa, Yoshinobu Saito, Naomi Tsunekawa, Tomohiro Manabe, OGUMA YUKO

Journal of Exercise Physiology online 18 ( 5 ) 79 - 85 2015.10

Research paper (scientific journal), Joint Work, Accepted

運動療法を普及するには運動療法の意義と日本の現状

小熊, 祐子

日本臨床スポーツ医学会誌 23 ( 3 ) 387 - 391 2015.08

ISSN 1346-4159

アスリートの内側型距骨骨軟骨損傷に対する関節鏡視下経内果的骨軟骨移植術の検討

橋本健史, 勝川史憲, 石田浩之, 小熊祐子, 真鍋知宏

日本臨床スポーツ医学会誌 23 ( 3 ) 573 - 576 2015.08

ISSN 1346-4159

本研究の目的は、アスリートの内側型距骨骨軟骨損傷に対して関節鏡視下経内果的骨軟骨移植術を行った症例を調査し本手術法の有用性と問題点を検討することである。術前に日常的にスポーツを行っていた4例4足を対象とした。性別は男3例、女1例で、年齢は中央値35歳であった。手術方法は、前外側ポータルから足関節鏡視を行い、脛骨内果にリーマーを用いて骨孔を開け、これを利用して膝蓋大腿関節面から採取した骨軟骨柱を移植した。術後経過観察期間は中央値3年1ヵ月であった。疼痛は著しく改善され、元のレベルへのスポーツ復帰は平均4.0ヵ月であった。アスリートの距骨滑車内側型骨軟骨障害に対して関節鏡視下経内果的骨軟骨移植術、3年1ヵ月の経過でも、満足する結果を得ることができた。(著者抄録)

ログデータと健康管理・ウェアラブルデバイスによる健康管理の可能性～身体活動を中心に～

OGUMA YUKO

日本バーチャルリアリティ学会誌・特集「ライフログと健康」 (日本バーチャルリアリティ学会) 20 ( 2 ) 26-30 2015.06

Research paper (scientific journal), Joint Work

スクリーンタイムとメタボリックシンドロームとの関連　神奈川県藤沢市の特定健診受診者を対象とした横断研究

齋藤義信, 小熊祐子, 井上茂, 田中あゆみ, 稲次潤子, 小堀悦孝

運動器リハビリテーション 26 ( 1 ) 62 - 70 2015.05

ISSN 2187-8420

目的:スクリーンタイム(ST)とメタボリックシンドローム(MetS)該当の有無との関連を検討すること。方法:40〜69歳の2009年藤沢市特定健診受診者のうち、質問紙に回答のあった2,449名を分析対象とし、ST(4分位)とMetS該当との関連を解析した。結果:身体活動量や食生活、基本属性などを調整してもなお、STが長いほどMetS該当者が多かった(P for trend<0.001)。結語:MetS対策には身体活動促進に加え、座位行動減少を考慮する必要性が示唆された。(著者抄録)

高強度インターバルトレーニングと血清脳由来神経栄養因子(BDNF)濃度との関連

東, 宏一郎, 大澤, 祐介, 田畑, 尚吾, 堀澤, 栞里, 勝川, 史憲, 石田, 浩之, 小熊, 祐子, 河合, 俊英, 小口, 修司, 太田, 敦美, 菊池, 春人, 村田, 満, 松本, 秀男

体力科学 64 ( 2 ) 227 - 232 2015.04

ISSN 0039-906X

75g経口糖負荷試験(OGTT)の経時的変化と血中脂肪酸分画、体脂肪分布の関連

河合, 俊英, 東, 宏一郎, 藤井, 千華子, 小熊, 祐子, 松本, 秀男, 伊藤, 裕

日本内分泌学会雑誌 91 ( 1 ) 357 2015.04

ISSN 0029-0661

太極拳によるフロー体験とSense of Coherence(SOC)の関係

OGUMA YUKO

KEIO SFC JOURNAL・特集「スポーツ」の多様性を探る (慶應義塾大学湘南藤沢学会) 14 ( 2 ) 132-145 2015.03

Research paper (scientific journal), Joint Work, Accepted

けがをしない身体をつくるために

OGUMA YUKO

KEIO SFC JOURNAL・特集「スポーツ」の多様性を探る (慶應義塾大学湘南藤沢学会) 14 ( 2 ) 076-084 - 84 2015.03

Research paper (scientific journal), Joint Work, Accepted, ISSN 1347-2828

特集「スポーツ」の多様性を探る#招待論文#スポーツと健康スポーツ傷害予防のためのウォーミングアッププログラムは, その議論が始まったばかりであり, さらなる研究が待たれるフィールドである。今後は, 本当に必要なプログラムの厳選とその科学的根拠, スポーツ種目による取捨選択方法, 練習時間, 頻度などの包括的プログラムの研究が必要である。われわれは現在, 小型の加速度・角速度計を搭載したウェアラブル端末を開発中である。これは運動時にリアルタイムで自身の動作解析を行えるデバイスであり, フォームの確認やスポーツ傷害を起こしやすい動作の矯正に利用したいと考えている。

身体活動と健康アクティブガイドを活用して

OGUMA YUKO

KEIO SFC JOURNAL・特集「スポーツ」の多様性を探る (慶應義塾大学湘南藤沢学会) 14 ( 2 ) 086-102 2015.03

Research paper (scientific journal), Single Work, Accepted

Whole-body viration

OGUMA YUKO

臨床雑誌『整形外科』 (東京) 66 ( 3 ) 244-251 2015.03

Research paper (scientific journal), Joint Work

運動器治療機器最前線(第9回) Whole-body vibration

大澤, 祐介, 小熊, 祐子, 橋本, 健史

整形外科 66 ( 3 ) 244 - 251 2015.03

ISSN 0030-5901

アスリートの陳旧性足関節外側靱帯損傷に対する短腓骨筋腱を用いた足関節外側靱帯再建術の検討

橋本, 健史, 勝川, 史憲, 石田, 浩之, 小熊, 祐子 and 真鍋, 知宏

日本臨床スポーツ医学会誌 23 ( 1 ) 45 - 49 2015.01

ISSN 1346-4159

本研究の目的は、アスリートの陳旧性足関節外側靱帯損傷に対して短腓骨筋腱を用いた足関節外側靱帯再建術を行った症例を調査し本手術法の有用性と問題点を検討することである。術前に日常的にスポーツを行っていた20例22足を対象とした。性別は男8例、女12例で、年齢は平均24.0歳であった。手術方法は短腓骨筋腱を半切遊離して移植腱として用い、前距腓靱帯、踵腓靱帯を解剖学的位置に再建した。術後経過観察期間は平均4年8ヵ月であった。疼痛は著しく改善され、元のレベルへのスポーツ復帰は平均6.1ヵ月であった。アスリートの陳旧性足関節外側靱帯損傷に対して短腓骨筋腱を用いた足関節外側靱帯再建術は、4年8ヵ月の経過でも、満足する結果を得ることができた。(著者抄録)

アスリートの内側型距骨軟骨損傷に対する関節鏡下経内果的骨軟骨移植術の検討

橋本健史, 勝川史憲, 石田浩之, 小熊祐子, 真鍋知宏

日本臨床スポーツ医学会誌 23 ( 3 ) 573 - 576 2015

Research paper (scientific journal), Accepted, ISSN 1346-4159

Association of serum BDNF concentration with high-intensity interval training

Koichiro, Azuma, Yusuke, Osawa, Shogo, Tabata, Shiori, Horisawa, Fuminori, Katsukawa, Hiroyuki, Ishida, Yuko, Oguma, Toshihide, Kawai, Shuji, Oguchi, Atsumi, Ota, Haruhito, Kikuchi, Mitsuru, Murata and Hideo, Matsumoto

Japanese Journal of Physical Fitness & Sports Medicine (Japanese Society of Physical Fitness and Sports Medicine) 64 ( 2 ) 227 - 232 2015

ISSN 0039906X

To evaluate the association of serum BDNF concentration with high-intensity interval training, 12 healthy male volunteers, aged 28-48 years, completed 16-week high-intensity interval training (HIIT) using ergometer. Training program consisted of &gt
90% VO2 peak for 60 sec separated by 60 sec active rest period for 8-12 sets twice weekly for 16-week. Maximal exercise tolerance tests were performed before (0-week), 4-week, and 16-week after the intervention program. VO2 peak as well as peak watt was linearly increased after 4-week (9% for both VO2 peak and peak watt) and 16-week HIIT training (15% for VO2 peak and 18% for peak watt, p&lt
0.01). However, there was no change in serum BDNF concentration by HIIT. On the other hand, there was a positive association of serum BDNF concentration at baseline with % increase in peak watt after the intervention (ρ=0.60, p&lt
0.05). The association between BDNF and exercise training is still unclear, and more studies are needed to clarify the above positive association.

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身体活動量増加のためのコミュニティ・ワイド・キャンペーン研究プロトコル

齋藤, 義信, 小熊, 祐子, 田中, あゆみ, 相原, 陽子, 鎌田, 真光, 井上, 茂, 稲次, 潤子

体力科学 63 ( 6 ) 682 2014.12

ISSN 0039-906X

世界標準化身体活動質問票(GPAQ)第2版日本語版の妥当性・再現性評価

小熊, 祐子, 渡邉, 智子, 斎藤, 義信, 田中, あゆみ, 田中, 茂穂, 井上, 茂

体力科学 63 ( 6 ) 664 2014.12

ISSN 0039-906X

健常男性における高強度インターバル運動の効果

東, 宏一郎, 大澤, 祐介, 長野, 雅史, 田畑, 尚吾, 堀澤, 栞里, 勝川, 史憲, 小熊, 祐子, 石田, 浩之, 河合, 俊英, 松本, 秀男

日本臨床スポーツ医学会誌 22 ( 4 ) S159 2014.10

ISSN 1346-4159

運動処方のためのtreadmill protocol 「KEIO-SENIOR」(K)とBruce protocol(B)との対比

河合, 俊英, 東, 宏一郎, 藤井, 千華子, 小熊, 小熊祐子, 勝川, 史憲, 田畑, 尚吾, 堀澤, 栞里, 石田, 浩之, 松本, 秀男, 伊藤, 裕

肥満研究 20 ( Suppl. ) 172 2014.10

ISSN 1343-229X

運動処方作成を目的としたトレッドミルプロトコール「KEIO-SENIOR」(K)と心筋虚血の評価を目的とした「Bruce」(B)プロトコールの対比

河合, 俊英, 東, 宏一郎, 藤井, 千華子, 小熊, 小熊祐子, 勝川, 史憲, 田畑, 尚吾, 堀澤, 栞里, 石田, 浩之, 松本, 秀男, 伊藤, 裕

日本臨床スポーツ医学会誌 22 ( 4 ) S117 2014.10

ISSN 1346-4159

アスリートの内側型距骨骨軟骨損傷に対する関節鏡視下経内果的骨軟骨移植術の検討

橋本, 健史, 勝川, 史憲, 石田, 浩之, 小熊, 祐子 and 真鍋, 知宏

日本臨床スポーツ医学会誌 22 ( 4 ) S216 2014.10

ISSN 1346-4159

運動療法を普及するには運動療法の意義と日本の現状

小熊祐子

日本臨床スポーツ医学会誌 22 ( 4 ) S102 2014.10

ISSN 1346-4159

太極拳によるフロー体験とSOCの関係生きがい感と自己効力感を介して

飯田健次, 小熊祐子

日本健康教育学会誌 22 ( Suppl. ) 90 2014.07

ISSN 1340-2560

スクリーンタイムとメタボリックシンドロームとの関連　神奈川県藤沢市の特定健診受診者を対象とした横断研究

齋藤義信, 小熊祐子, 井上茂, 田中あゆみ, 稲次潤子, 小堀悦孝

日本運動療法学会大会抄録集 39回 39 2014.06

運動療法　ステップアップで考えよう―より効果的な方法と継続への道―

小熊祐子

PRACTICE 31 ( 3 ) 306 - 308 2014.05

Research paper (scientific journal), Single Work, ISSN 0289-4947

スポーツが切り開く健康

小熊祐子

慶應義塾医学部新聞 2014.04

Research paper (other academic), Single Work

2型糖尿病者の体力指標における性差と罹病期間の影響の検討

東, 宏一郎, 田畑, 尚吾, 堀澤, 栞里, 河合, 俊英, 小熊, 祐子, 石田, 浩之, 勝川, 史憲, 伊藤, 裕, 松本, 秀男

糖尿病 57 ( Suppl.1 ) S - 468 2014.04

ISSN 0021-437X

運動療法　ステップアップで考えよう―Sedentaryの解消―

小熊祐子

PRACTICE 31 ( 2 ) 164 - 167 2014.03

Research paper (scientific journal), Single Work

運動療法　ステップアップで考えよう　Sedentaryの解消

小熊祐子

PRACTICE 31 ( 2 ) 164 - 167 2014.03

ISSN 0289-4947

The Relationaships Between Flow Experience and Sense of Coherence

Kenji Iida, OGUMA YUKO

Holistic Nursing Practice 92-97 2014.03

Research paper (scientific journal), Joint Work, Accepted

The relationship between flow experience and sense of coherence: a 1-year follow-up study

Iida, K. and Oguma, Y.

Holist Nurs Pract 28 ( 2 ) 91 - 97 2014.03

ISSN 1550-5138

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質問紙で評価した身体活動ガイドライン達成者の活動レベルを加速度計で評価する

中田, 由夫, 井上, 茂, 大河原, 一憲, 岡, 浩一朗, 小熊, 祐子, 高田, 和子, 田中, 茂穂, 田中, 千晶

体力科学 63 ( 1 ) 73 2014.02

ISSN 0039-906X

運動療法　ステップアップで考えよう―アクティブガイドの活用―

小熊祐子

PRACTICE 31 ( 1 ) 35 - 37 2014.01

Research paper (scientific journal), Single Work, ISSN 0289-4947

青壮年の身体活動基準値策定のためのエビデンス

小熊祐子

臨床スポーツ医学 31 ( 1 ) 26 - 29 2014.01

Research paper (scientific journal), Single Work

【新しい身体活動基準・アクティブガイドをめぐって】青壮年の身体活動基準値策定のためのエビデンス

小熊祐子

臨床スポーツ医学 31 ( 1 ) 26 - 29 2014.01

ISSN 0289-3339

Effects of 16-week high-intensity interval training using upper and lower body ergometers on aerobic fitness and morphological changes in healthy men: a preliminary study

Osawa, Y., Azuma, K., Tabata, S., Katsukawa, F., Ishida, H., Oguma, Y., Kawai, T., Itoh, H., Okuda, S. and Matsumoto, H.

Open Access J Sports Med 5 257 - 265 2014

ISSN 1179-1543

It is unclear whether combined leg and arm high-intensity interval training (HIIT) improves fitness and morphological characteristics equal to those of leg-based HIIT programs. The aim of this study was to compare the effects of HIIT using leg-cycling (LC) and arm-cranking (AC) ergometers with an HIIT program using only LC. Effects on aerobic capacity and skeletal muscle were analyzed. Twelve healthy male subjects were assigned into two groups. One performed LC-HIIT (n=7) and the other LC- and AC-HIIT (n=5) twice weekly for 16 weeks. The training programs consisted of eight to 12 sets of >90% VO2 (the oxygen uptake that can be utilized in one minute) peak for 60 seconds with a 60-second active rest period. VO2 peak, watt peak, and heart rate were measured during an LC incremental exercise test. The cross-sectional area (CSA) of trunk and thigh muscles as well as bone-free lean body mass were measured using magnetic resonance imaging and dual-energy X-ray absorptiometry. The watt peak increased from baseline in both the LC (23%+/-38%; P<0.05) and the LC-AC groups (11%+/-9%; P<0.05). The CSA of the quadriceps femoris muscles also increased from baseline in both the LC (11%+/-4%; P<0.05) and the LC-AC groups (5%+/-5%; P<0.05). In contrast, increases were observed in the CSA of musculus psoas major (9%+/-11%) and musculus anterolateral abdominal (7%+/-4%) only in the LC-AC group. These results suggest that a combined LC- and AC-HIIT program improves aerobic capacity and muscle hypertrophy in both leg and trunk muscles.

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運動療法ステップアップで考えよう－Sedentaryの解消―

小熊祐子

PRACTICE 31 ( 2 ) 164 - 167 2014

Effects of vibration on flexibility: a meta-analysis

Osawa, Y. and Oguma, Y.

J Musculoskelet Neuronal Interact 13 ( 4 ) 442 - 53 2013.12

ISSN 1108-7161

Exogenous stimulation of skeletal muscle or tendon is often used to improve range of motion. Despite substantial research efforts, however, the effects of vibration on flexibility have not been clarified. In this review, we investigated the effects of acute and chronic intervention programs which used vibration to improve flexibility in young healthy individuals. Effect size was calculated using data from a total of 600 participants in 19 studies before and after the introduction of vibration-based intervention, and a total of 324 participants in 13 studies on the additive effects of vibration compared with the identical conditions without vibration. Sub-group analyses were performed based on intervention period, type of exercise, and type of vibration. Meta-analysis showed that vibration interventions had significant effects on flexibility (standardized mean difference [SMD]=-0.79, 95% confidence interval [CI]=-1.14- -0.43; p<0.001), albeit with the possibility of heterogeneity (I(2)=75%). Another meta-analysis revealed a significant additive effect of vibration on flexibility compared with the identical condition without vibration (SMD=0.25, 95%CI=0.03-0.48; P=0.03), with small heterogeneity (I(2)=0%). The risk of publication bias was low judged from Kendall's tau statistic. We concluded that the use of vibration might lead to additive improvements in flexibility.

通勤時に仕事時間内に歩数を増やす

小熊祐子

旬刊健康管理情報健康のひろば ( 1837 ) 2013.10

Research paper (other academic), Single Work

特集糖尿病運動療法：運動指導成功のためのノウハウ―ホップ・ステップ・ジャンプ―

OGUMA YUKO

臨床スポーツ医学 (東京) 30 ( 10 ) 931 - 937 2013.10

Research paper (scientific journal), Single Work, ISSN 0289-3339

【総論】糖尿病発症予防のための身体活動―身体活動・身体フィットネスは糖尿病を予防するか―

小熊祐子

臨床スポーツ医学 30 ( 10 ) 931-937 2013.10

Research paper (scientific journal), Single Work

高強度インターバルトレーニングと血中BDNF濃度との関連

日本臨床スポーツ医学会誌 21 ( 4 ) S262 2013.10

ISSN 1346-4159

アスリートの陳旧性足関節外側靱帯損傷に対する短腓骨筋腱を用いた足関節外側靱帯再建術の検討

橋本, 健史, 勝川, 史憲, 石田, 浩之, 小熊, 祐子 and 真鍋, 知宏

日本臨床スポーツ医学会誌 21 ( 4 ) S179 2013.10

ISSN 1346-4159

【糖尿病運動療法:運動指導成功のためのノウハウ-ホップ・ステップ・ジャンプ-】糖尿病発症予防のための身体活動　身体活動・身体フィットネスは糖尿病を予防するか

小熊祐子

臨床スポーツ医学 30 ( 10 ) 931 - 937 2013.10

ISSN 0289-3339

ヒト血中脂肪酸分画と体脂肪分布、経口糖負荷試験(OGTT)時の各指標との関連

河合, 俊英, 小熊, 小熊祐子, 勝川, 史憲, 東, 宏一郎, 松本, 秀男, 伊藤, 裕

肥満研究 19 ( Suppl. ) 201 2013.09

ISSN 1343-229X

Relationaships Between Flow Experience, IKIGAI, and Sense of Coherence in Tai Chi Practitioners

Iida, K. and Oguma, Y.

Holistic Nursing Practice 27 ( 5 ) 260 - 267 2013.09

Research paper (scientific journal), Joint Work, Accepted, ISSN 1550-5138

The purpose of this study was to examine the mental health effects of Tai chi on regular practitioners by investigating the relationships between flow experience, IKIGAI (Japanese: "Life worth living"), and sense of coherence. The results indicated that flow experience may influence IKIGAI and IKIGAI may influence sense of coherence; this suggests that IKIGAI may act as an intermediary between flow experience and sense of coherence. The results also indicated that the longer the Tai chi experience, the higher was the flow experience.

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Effects of vibration on flexibility:a meta-analysis

Osawa Y. and Oguma Y.

J MusculoskeletNeuronal Interact 13 ( 4 ) 442 - 453 2013.09

Research paper (scientific journal), Joint Work, Accepted

The effects of whole-body vibration on muscle strength and power: a meta-analysis

Osawa, Y., Oguma, Y. and Ishii, N.

J Musculoskelet Neuronal Interact 13 ( 3 ) 380 - 90 2013.09

ISSN 1108-7161

Exercise with whole-body vibration (WBV) is becoming popular as an alternative to conventional training or as supplementary training. However, despite increasing research efforts in this field, additive effects of WBV on muscle performance remain unclarified. In this review, we investigated the additive effects of long-term WBV on muscle strength and power. This meta-analysis was restricted to randomized controlled trials lasting for at least 5 weeks comparing exercise with and without WBV, or comparing only WBV exposure and control. Data from a total of 314 participants in 10 studies on knee extension muscle strength, and 249 participants in 7 studies on countermovement jump height were pooled using random-effect models. Meta-analysis showed significant additional effects of WBV on muscle strength (standardized mean difference [SMD]=0.76, 95% confidence interval [CI]=0.21-1.32; p=0.007) and countermovement jump (SMD=0.87, 95% CI=0.29-1.46; p=0.003). Based on these findings, we concluded that the use of WBV would lead to greater improvements in both knee extension muscle strength and countermovement jump than under identical conditions without WBV.

話題のトレーニングを検証するバイブレーション・トレーニング

大澤, 祐介, 小熊, 祐子 and 石井, 直方

日本臨床スポーツ医学会誌 21 ( 3 ) 513 - 516 2013.08

ISSN 1346-4159

【健康づくりのための身体活動基準・指針2013】健康づくりのための身体活動基準2013とアクティブガイドの策定手順と概要

宮地, 元彦, 村上, 晴香, 川上, 諒子, 田中, 憲子, 田中, 茂穂, 高田, 和子, 宮武, 伸行, 小熊, 祐子, 澤田, 亨, 種田, 行男, 田畑, 泉

臨床栄養 123 ( 1 ) 24 - 30 2013.07

ISSN 0485-1412

千葉県所在のゴルフ場の運営状況およびAED設置状況に関する調査

木庭大輔, 大澤祐介, 小熊祐子

ゴルフの科学 (東京) 25 ( 2 ) 1 - 8 2013.06

Research paper (scientific journal), Joint Work

元気のひけつ

小熊祐子

朝日新聞 (東京朝日新聞社) 19 2013.06

Research paper (other academic), Single Work

集合住宅における健康サポートプログラムの効果検証 6ヵ月間の無作為化比較試験

小熊祐子, 祐子, 東, 宏一郎, 大澤, 祐介, 富田, 眞紀子, 鶴野, 亮子, 今村, 晴彦, 八木, 紫, 布施, 努, 真鍋, 知宏

日本抗加齢医学会総会プログラム・抄録集 13回 213 2013.06

The effects of whole-body vibration on muscle strength and power:a meta-analysis

Osawa Y., Oguma Y., Ishii N.

J MusculoskeletNeuronal Interact 13 ( 3 ) 342 - 352 2013.05

Research paper (scientific journal), Joint Work, Accepted

Environmental and individual correlates of various types of physical activity among community-dwelling middle-aged and elderly Japanese.

Saito, Y., Oguma, Y., Inoue, S., Tanaka, A. and Kobori, Y.

Int J Environ Res Public Health 10 ( 5 ) 2028 - 2042 2013.05

Research paper (scientific journal), Joint Work, Accepted, ISSN 1660-4601

Recent studies have suggested the importance of the neighborhood environment in determining the specific type of physical activity. However, few studies on this topic have been undertaken in Japan. This study examined the association of three types of physical activity and their associations with individual and neighborhood environmental factors among middle-aged and elderly Japanese. Participants were 2,449 adults aged 40-69 living in Fujisawa city who had undergone health checkups and responded to our survey by mail. Individual factors, the International Physical Activity Questionnaire (long form), and its environmental module acted as inputs to the study. The adjusted odds ratios (ORs) of high levels of moderate-to-vigorous intensity leisure-time physical activity (LTPA), walking for active recreation, and transportation were calculated in relation to individual and neighborhood environmental factors through multiple logistic regression models. Not working and good self-rated health were significantly associated with a higher level of each physical activity outcome. According to the adjusted ORs, higher educational attainment, higher economic status, good access to exercise facilities, and owning motor vehicles were associated with longer LTPA time. However, different sets of factors were associated with longer walking times for recreation and transportation. The results suggest that diverse individual and neighborhood environmental characteristics are associated with different physical activity outcomes. Therefore, customizing environments to become activity-friendly is necessary to increase physical activity effectively among middle-aged and elderly Japanese.

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新しいエクササイズガイドを考える運動基準策定のエビデンス

澤田, 亨, 田畑, 泉, 種田, 行男, 小熊, 祐子, 宮武, 伸行, 田中, 茂穂, 高田, 和子, 村上, 晴香, 田中, 憲子, 川上, 諒子 and 宮地, 元彦

日本臨床スポーツ医学会誌 21 ( 2 ) 323 - 326 2013.04

ISSN 1346-4159

Effects of combining whole-body vibration with exercise on the consequences of detraining on muscle performance in untrained adults.

Osawa, Y. and Oguma, Y.

J Strength Cond Res 27 ( 4 ) 1074 - 1082 2013.04

Research paper (scientific journal), Joint Work, Accepted, ISSN 1533-4287

This study investigated whether whole-body vibration (WBV) coupled with low-velocity exercise (EX) for 13 weeks retains muscle performance gains after 5 weeks of subsequent detraining compared with the results of an identical EX program without WBV. Thirty-two untrained healthy adults (22-49 years of age) were randomly assigned to groups that performed EX with or without WBV (EX-WBV and EX, respectively; n = 16 per group). The following outcome variables were evaluated: countermovement jump height; maximal isometric, concentric, and eccentric knee extension strengths; local muscular endurance; and lumbar extension torque before, during, and after the 13-week training period, and after 5 weeks of detraining. Compared with the EX group, significantly higher increases in countermovement jump height and isometric and concentric knee extension strengths were detected in the EX-WBV group after the 13-week training period. However, detraining caused significant declines in these 3 muscle performance tests only in the EX-WBV group (-4.8, -10.2, and -17.2%, respectively), resulting in no significant differences between the test and control groups after the detraining period. After detraining, all examined variables showed significantly better performance compared with pretraining (p < 0.05) and did not significantly differ from midtraining (7 weeks) in both groups (p > 0.05). These results suggest that muscle strength in the lower extremities, particularly isometric and concentric contractions, and muscle power might be more susceptible to short-term detraining effects when exercise is combined with WBV. Thus, it is necessary to perform regular exercise to maximize the benefits of WBV on muscle strength and power during the early stages of training in previously untrained individuals.

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腎臓病患者の食事

OGUMA YUKO

保健の科学 (杏林書院) 55 ( 4 ) 273-279 - 279 2013.04

Research paper (scientific journal), Joint Work, ISSN 0018-3342

体脂肪分布、血中脂肪酸分画、経口糖負荷試験(OGTT)時の各指標の経時的変化の関連

河合, 俊英, 小熊, 小熊祐子, 勝川, 史憲, 東, 宏一郎, 田中, 久美子, 目黒, 周, 税所, 芳史, 松本, 秀男, 伊藤, 裕

糖尿病 56 ( Suppl.1 ) S - 437 2013.04

ISSN 0021-437X

実践栄養学の航跡(第12回)　腎臓病患者の食事

山下光雄, 小熊祐子

保健の科学 55 ( 4 ) 273 - 279 2013.04

ISSN 0018-3342

高強度インターバルトレーニングの運動耐容能・体組成及び代謝指標への効果

東, 宏一郎, 大澤, 祐介, 田畑, 尚吾, 勝川, 史憲, 石田, 浩之, 小熊, 祐子, 河合, 俊英, 伊藤, 裕, 奥田, 茂男, 小口, 修司, 太田, 敦美, 石橋, みどり, 菊池, 春人, 村田, 満, 松本, 秀男

糖尿病 56 ( Suppl.1 ) S - 331 2013.04

ISSN 0021-437X

GISで評価した近隣環境と余暇・移動時の歩行時間との関連について

頼, 建豪, 齋藤, 義信, 小熊, 祐子

運動疫学研究: Research in Exercise Epidemiology 15 ( 1 ) 47 2013.03

ISSN 1347-5827

【巻頭】運動疫学をふりかえり,そして,これからを考える

小熊祐子

運動疫学研究 15 ( 1 ) 2013.03

Research paper (scientific journal), Single Work

糖尿病患者の食事

OGUMA YUKO

保健の科学 (杏林書院) 55 ( 3 ) 199-207 - 207 2013.03

Research paper (scientific journal), Joint Work, ISSN 0018-3342

Relationship between Positive Emotions by EEG and Flow experience In Tai Chi practitioners

飯田健次,小熊祐子

Journal of International Society of Life Information Science 31 ( 1 ) 7 - 16 2013.03

Research paper (scientific journal), Joint Work, ISSN 1341-9226

本研究は定期的に太極拳練習を行っている男女を対象に脳波(Electroencephalogram:EEG)によるポジティブ感情(積極快)と、質問紙調査によるフロー体験の関係を調査した。積極快と質問紙調査で得られたフロー値との相関は、上級者では有意な相関が見られたが、初心者では有意な相関が見られなかった。さらに、同対象者に対して2年間の縦断研究を行ったところ、上級者は積極快の切片がすでに高く2年間に有意な変化は見られなかったが、初心者は積極快の切片は低かったため2年間に有意な変化が見られた。(著者抄録)

【健康づくりのための身体活動基準・指針2013の概要】

宮地, 元彦, 村上, 晴香, 澤田, 亨, 川上, 諒子, 田中, 憲子, 田中, 茂穂, 高田, 和子, 宮武, 伸行, 小熊, 祐子, 種田, 行男, 田畑, 泉

日本栄養士会雑誌 56 ( 3 ) 166 - 175 2013.03

ISSN 2187-4476

過去の身体活動疫学に関する研究を網羅的に収集・精読するシステマティックレビュー、ならびに生活習慣病予防、癌予防、運動器障害や認知症の予防と身体活動・運動・体力との関係を客観的に分析したメタ解析の成果を紹介した。この研究成果を基に、厚生労働省の「運動基準・運動指針の改定に関する検討会」において、新しい基準・指針のあり方について方向性が示されたので、その論点と今後の活用のあり方について概説した。

実践栄養学の航跡(第11回)　糖尿病患者の食事

山下光雄, 小熊祐子

保健の科学 55 ( 3 ) 199 - 207 2013.03

ISSN 0018-3342

質問紙で評価した身体活動ガイドライン達成者の活動レベルを加速度計で評価する研究計画

中田, 由夫, 井上, 茂, 大河原, 一憲, 岡, 浩一朗, 小熊, 祐子, 高田, 和子, 田中, 茂穂, 田中, 千晶

運動疫学研究: Research in Exercise Epidemiology 15 ( 1 ) 51 2013.03

ISSN 1347-5827

実践栄養学の航跡(第10回)　栄養補助食品

山下光雄, 小熊祐子

保健の科学 55 ( 2 ) 135 - 142 2013.02

ISSN 0018-3342

栄養補助食品

OGUMA YUKO

保健の科学 (杏林書院) 55 ( 2 ) 135-142 - 142 2013.02

Research paper (scientific journal), Joint Work, ISSN 0018-3342

Effects of resistance training with whole-body vibration on muscle fitness in untrained adults

Osawa, Y. and Oguma, Y.

Scand J Med Sci Sports 23 ( 1 ) 84 - 95 2013.02

ISSN 1600-0838

The effects of resistance training (RT) combined with whole-body vibration (WBV) on muscle fitness, particularly muscle hypertrophy and neuromuscular performance, are not well understood. We investigated the effects of WBV in healthy, untrained participants after a 13-week RT course by performing magnetic resonance imaging and by measuring maximal isometric (with electromyography) and isokinetic knee extension strengths, isometric lumbar extension torque, countermovement-jump, knee extension endurance, and sit-ups. Thirty-two individuals (22-49 years old) were randomly assigned to RT groups with (RT-WBV, n=16) or without WBV (RT, n=16). Following the RT course, significantly higher increases in the cross-sectional areas of m. psoas major (vs baseline values) and erector spinae muscle (vs the RT group) were observed in the RT-WBV group (+10.7%, P<0.05; +8.7%, P<0.05) compared with the RT group (+3.8%, P=0.045; 0.0%). Higher increases from baseline were also observed in maximal isometric force, concentric knee extension torque, countermovement-jump, and maximal isometric lumbar extension torque in RT-WBV (+63.5%; +76.7%, +15.0%, and +51.5%, respectively; P<0.05) than in those of RT (+25.6%, P=0.001; +17.8%, P=0.18; +11.3%, P=0.001; and +26.4%, P<0.001, respectively). The WBV-induced increases in muscle hypertrophy and isometric lumbar extension torque suggest a potential benefit of incorporating WBV into slow-velocity RT programs involving exercises of long duration.

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周術期の食事

OGUMA YUKO

保健の科学 (杏林書院) 55 ( 1 ) 53-59 - 59 2013.01

Research paper (scientific journal), Joint Work, ISSN 0018-3342

実践栄養学の航跡(第9回)　周術期の食事

山下光雄, 小熊祐子

保健の科学 55 ( 1 ) 53 - 59 2013.01

ISSN 0018-3342

特集　糖尿病運動療法：運動指導成功のためのノウハウ－ホップ・ステップ・ジャンプ－

小熊祐子

臨床スポーツ医学 (東京) 30 ( 10 ) 923 - 995 2013

サイエンスで健康に！　第3回　スポーツが切り開く健康

738号 2013

平成25年度県民スポーツ週間中央イベント楽らくウォーク　講演「楽らくウォークで健康に」

小熊祐子

2013

スクリーンタイムと推奨身体活動量のメタボリックシンドロームとの関連

齋藤, 義信, 小熊, 祐子, 井上, 茂, 田中, あゆみ, 小堀, 悦孝

体力科学 61 ( 6 ) 707 2012.12

ISSN 0039-906X

人工栄養②―食事摂取不能者の栄養補給（成人）―

OGUMA YUKO

保健の科学 (杏林書院) 54 ( 12 ) 841-846 - 846 2012.12

Research paper (scientific journal), Joint Work, ISSN 0018-3342

実践栄養学の航跡(第8回)　人工栄養　食事摂取不能者の栄養補給(成人)

山下光雄, 小熊祐子

保健の科学 54 ( 12 ) 841 - 846 2012.12

ISSN 0018-3342

「健康づくりのための運動基準2006」における「健康づくりのための最大酸素摂取量の基準値」と生命予後に関するコホート研究

澤田, 亨, 宮地, 元彦, 田中, 茂穂, 高田, 和子, 田畑, 泉, 種田, 行男, 小熊, 祐子, 宮武, 伸行, 岡本, 隆史, 塚本, 浩二

体力科学 61 ( 6 ) 704 2012.12

ISSN 0039-906X

実践栄養学の航跡(第7回)　人工栄養　乳幼児の場合(哺乳器を含む)

山下光雄, 小熊祐子

保健の科学 54 ( 11 ) 777 - 782 2012.11

ISSN 0018-3342

人工栄養①―乳幼児の場合（哺乳器を含む）―

OGUMA YUKO

保健の科学 (杏林書院) 54 ( 11 ) 777-782 - 782 2012.11

Research paper (scientific journal), Joint Work, ISSN 0018-3342

新しいエクササイズガイドを考える運動基準策定のエビデンス

澤田, 亨, 田畑, 泉, 種田, 行男, 小熊, 祐子, 宮武, 伸行, 田中, 茂穂, 高田, 和子, 村上, 晴香, 田中, 憲子, 川上, 諒子 and 宮地, 元彦

日本臨床スポーツ医学会誌 20 ( 4 ) S104 2012.10

ISSN 1346-4159

スポーツ選手に起こる貧血の原因と予防策

小熊祐子

コーチングクリニック 2012.10

Research paper (other academic), Single Work

中高年肥満・糖尿病患者に対する運動処方作成を目的としたトレッドミルプロトコール(KEIO-SENIOR)とその臨床応用

河合, 俊英, 小熊, 小熊祐子, 勝川, 史憲, 東, 宏一郎, 石田, 浩之, 松本, 秀男, 伊藤, 裕

日本臨床スポーツ医学会誌 20 ( 4 ) S217 2012.10

ISSN 1346-4159

横足根関節の機能に着目したテーピングの検討足関節内反捻挫後の踵部への方策

今井, 丈, 石橋, 秀幸, 隅田, 祥子, 真鍋, 知宏, 小熊, 祐子, 石田, 浩之, 勝川, 史憲, 橋本, 健史

日本臨床スポーツ医学会誌 20 ( 4 ) S187 2012.10

ISSN 1346-4159

話題のトレーニングを検証するバイブレーション・トレーニング

大澤祐介, 小熊祐子, 石井直方

日本臨床スポーツ医学会誌 20 ( 4 ) S92 2012.10

ISSN 1346-4159

高強度インターバルトレーニングによる体組成及び全身持久力への効果

大澤, 祐介, 東, 宏一郎, 岩本, 航, 田畑, 尚吾, 勝川, 史憲, 石田, 浩之, 小熊, 祐子, 岩本, 潤, 河合, 俊英, 奥田, 茂男, 松本, 秀男

日本臨床スポーツ医学会誌 20 ( 4 ) S170 2012.10

ISSN 1346-4159

【健康・スポーツ施策の動向】健康づくりのための運動基準2006の改定の手順と方向性

宮地元彦, 村上晴香, 川上諒子, 田中憲子, 田中茂穂, 高田和子, 宮武伸行, 小熊祐子, 澤田亨, 種田行男, 田畑泉

体育の科学 62 ( 9 ) 644 - 650 2012.09

ISSN 0039-8985

健康づくりのための運動基準2006の改定の手順と方向性

宮地元彦,村上晴香,川上諒子,田中憲子,田中茂穂,高田和子,宮武伸行, 小熊祐子,澤田亨,種田行男,田畑泉

体育の科学 ((株)杏林書院) 62 ( 9 ) 644 - 650 2012.09

Research paper (scientific journal), Joint Work, ISSN 0039-8985

中高年肥満者への運動処方作成を目的としたTreadmill protocol(KEIO-SENIOR)とその臨床応用

河合, 俊英, 小熊, 小熊祐子, 勝川, 史憲, 東, 宏一郎, 石田, 浩之, 松本, 秀男, 伊藤, 裕

肥満研究 18 ( Suppl. ) 167 2012.09

ISSN 1343-229X

高齢社会とスポーツの役割

小熊祐子

三田評論 2012.07

Research paper (scientific journal), Single Work

【運動とは何か】定期的な運動(身体活動)のもたらす健康上の効果

小熊祐子

公衆衛生 76 ( 6 ) 437 - 440 2012.06

ISSN 0368-5187

定期的な運動(身体活動)のもたらす健康上の効果

小熊祐子

公衆衛生 76 ( 6 ) 437 - 440 2012.06

Research paper (scientific journal), Single Work, Accepted

さまざまな機関・企業が注目する「健康マネジメント分野」で、社会のニーズに応えられる実践的な人材の育成に努める

小熊祐子

新医療 39 ( 6 ) 192 - 193 2012.06

Research paper (other academic), Single Work

[Epidemiological studies of physical activity and diabetes mellitus]

Oguma, Y.

Nihon Rinsho 70 ( 増刊3 最新臨床糖尿病学(上) ) 765 - 771 2012.05

ISSN 0047-1852

Epidemiological studies of physical activity and diabetes mellitus

OGUMA YUKO

Nihon Rinsho 70 ( 3 ) 765 - 771 2012.05

Research paper (scientific journal), Single Work, Accepted

2型糖尿病者に対する運動指導の効果と糖尿病罹病期間の関係

東, 宏一郎, 河合, 俊英, 小熊, 祐子, 石田, 浩之, 勝川, 史憲, 伊藤, 裕, 松本, 秀男

糖尿病 55 ( Suppl.1 ) 356 - 356 2012.04

ISSN 0021-437X

中高年者の運動処方作成を目的としたトレッドミルプロトコール(KEIO-SENIOR)とその臨床応用

河合, 俊英, 小熊, 小熊祐子, 勝川, 史憲, 東, 宏一郎, 石田, 浩之, 松本, 秀男, 伊藤, 裕

糖尿病 55 ( Suppl.1 ) 321 - 321 2012.04

ISSN 0021-437X

中高年集合住宅住民の身体活動量の検討 GPAQを用いて

頼, 建豪, 小熊, 祐子

Research in Exercise Epidemiology 14 ( 1 ) 71 2012.03

ISSN 1347-5827

住環境が健康に与える影響について～縦断的研究に関する文献レビュー～

冨田眞紀子, 小熊祐子

慶應義塾大学スポーツ医学研究センター紀要 33 - 37 2012.03

Research paper (bulletin of university, research institution), Joint Work

転倒・骨折予防のための運動介入研究について

小熊祐子

慶應義塾大学スポーツ医学研究センター紀要 17 - 19 2012.03

Research paper (bulletin of university, research institution), Single Work

「健康づくりのための運動基準2006」における「健康づくりのための最大酸素摂取量」の基準値と生命予後の関係　日本人男性労働者を対象にしたコホート研究

澤田, 亨, 宮地, 元彦, 田中, 茂穂, 高田, 和子, 田畑, 泉, 種田, 行男, 小熊, 祐子, 宮武, 伸行, 岡本, 隆史 and 塚本, 浩二

Research in Exercise Epidemiology 14 ( 1 ) 29 - 36 2012.03

Research paper (scientific journal), Joint Work, Accepted, ISSN 1347-5827

厚生労働省は「健康づくりのための最大酸素摂取量(MOU)」の基準値および範囲を示しているが、その値や範囲と生命予後との関連についての疫学的研究はなされていない。標記について、日本人労働者8935名(年齢中央値35歳、四分位範囲29〜43歳)を対象に検討した。MOUは1982〜1988年に実施した自転車エルゴメーターを用いた最大下運動負荷テストの結果から推定した。被験者を、上記の基準値および範囲を用いて、「範囲以下」群(I群)、「範囲の下限から基準値以下」群(II群)、「基準値から範囲の上限以下」群(III群)、「範囲の上限超」群(IV群)の4群に分類した後、2003年6月30日迄の死亡情報を確認した。観察期間中に360名が死亡した。I群を基準にした場合のII〜IV群の多変量調整ハザード比と95%信頼区間は、0.76(0.58〜0.99)、0.59(0.43〜0.80)、0.80(0.49〜1.31)で、上記の基準値を上回るMOUを持つ群は総死亡リスクが低いことが示唆された。

身体活動量の評価法

小熊, 祐子

Research in Exercise Epidemiology 14 ( 1 ) 59 2012.03

ISSN 1347-5827

東京都心部在住の超高齢者における身体活動質問紙および加速度計による評価

田中, 友規, 大澤, 祐介, 隅田, 祥子, 飯田, 健次, 原田, 昇, 小熊, 祐子

Research in Exercise Epidemiology 14 ( 1 ) 68 2012.03

ISSN 1347-5827

中高年者における日常身体活動および健康関連指標と環境要因との関係　藤沢市における検討

齋藤, 義信, 小熊, 祐子 and 小堀, 悦孝

体力科学 61 ( 1 ) 50 2012.02

ISSN 0039-906X

推奨運動量レベルの運動習慣と入院外医療費との関連　藤沢市における検討

齋藤, 義信, 小熊, 祐子, 鈴木, 清美, 相馬, 純子, 田中, あゆみ, 吉田, 幸平 and 小堀, 悦孝

厚生の指標 59 ( 2 ) 8 - 16 2012.02

Research paper (scientific journal), Joint Work, Accepted, ISSN 0452-6104

目的本研究は藤沢市国民健康保険被保険者を対象とした国保ヘルスアップモデル事業で得られたデータを用い,「健康づくりのための運動基準2006」で示された日本における推奨運動量(週4METs・時)レベルの運動習慣の継続・増加・減少という変化と医療費との関連について検討することを目的とした。方法対象は藤沢市国民健康保険被保険者1,343名(年齢63.3±5.1歳:Mean±SD)であった。医療費の分析は2002年度と2004年度の年間入院外医療費を用いた。運動習慣は質問紙により,1週間に1回30分以上の運動やスポーツを行う頻度について,事業開始時(2002年)と2年後(2004年)の追跡調査により評価した。その結果から,「運動習慣が週2回未満のまま推奨値を満たさなかった群(非推奨群)」,「週2回以上の推奨値から週2回未満に減少した群(減少群)」,「週2回未満から週2回以上に増加した群(増加群)」および「週2回以上継続し,推奨値を満たした群(推奨群)」の4群に分類した。運動習慣の変化と医療費との関連の検討には,始めに事業開始年度における医療費の群間比較を行った。その後,事業開始年度と事業最終年度の医療費の差(変化)の群間比較を多重比較検定にて行った。また重回帰分析を用いて,医療費の変化に関連する要因の検討を行った。結果事業開始年度の医療費は,運動習慣4群間で差はみられなかった。事業開始年度と事業最終年度の医療費の差の比較では,非推奨群と推奨群との間に有意差が認められた。事業開始年度と事業最終年度の医療費の差の平均値は,非推奨群では13,700円の増加,減少群では16,416円の増加,増加群では6,710円の増加,推奨群は94円の減少であった。重回帰分析を用いて医療費の変化に関連する要因を検討した結果,運動習慣において非推奨群に対し推奨群であることで有意に入院外医療費の増加が少なかった。一方,事業開始時の主観的健康感が低い,年齢が高い,糖尿病を治療中であることが増加に関連する要因であった。結論運動習慣は入院外医療費の増加に関連する要因であると考えられ,推奨運動量レベル以上の運動を継続することにより,入院外医療費の増加を抑制する傾向が示唆された。(著者抄録)

スポーツで健康に・・？

小熊祐子

15 - 20 2012

厚生労働科学研究費補助金（循環器疾患・糖尿病等生活習慣病対策総合研究事業）総括研究報告書健康づくりのための運動基準2006改定のためのシステマティックレビュー

宮地元彦, 田畑泉, 宮武伸行, 小熊祐子, 澤田亨, 種田行男, 田中茂穂, 高田和子, 川上諒子, 田中憲子, 村上晴香

2012

高齢社会とスポーツの役割

小熊祐子

三田評論 2012

中高齢者における移動のための自転車利用に関連する環境要因

齋藤, 義信, 小熊, 祐子, 井上, 茂, 田中, あゆみ, 小川, 芳弘, 高橋, 健, 鈴木, 清美, 小堀, 悦孝

体力科学 60 ( 6 ) 808 2011.12

ISSN 0039-906X

中高年のための健康支援システムの構築

小熊祐子

上原記念生命科学財団研究報告集 25 1 - 5 2011.12

Research paper (scientific journal), Single Work

健康的な生活習慣定着、QOL向上のためのインターネット・地域連携健康支援システムの構築を行った。ウェブ上での健康支援システムとして、食事記録システム、生活習慣・健康状態アセスメントシステムを開発し、藤沢市のシニアNPOなどの協力を得て13名(男8名、女5名、平均64.7歳)を対象に試用した。「ふれあい健康教室」を開催し、インターネット・地域連携コミュニティーの醸成を図った。藤沢市、藤沢市保健医療センター、大学とで健康増進システム作りのための定期的会議を行った。また、運動を行う上でハイリスクとなる参加者を同センターに紹介し、ヘルスチェックを受ける体制を試行し、平成22年度はハイリスク者4名のうち2名がセンターを受診した。

運動・スポーツと健康

小熊祐子

学校運営 (学校運営研究会) 53 ( 8 ) 24 - 27 2011.11

Research paper (scientific journal), Single Work, ISSN 1343-5906

齋藤, 義信, 小熊, 祐子, 井上, 茂, 田中, あゆみ, 鈴木, 清美, 相馬, 純子, 小堀, 悦孝

日本公衆衛生学会総会抄録集 70回 485 2011.10

ISSN 1347-8060

振動を利用した筋力トレーニングによる筋力及び体幹筋横断面積への影響運動習慣のない健常成人を対象に

大澤, 祐介, 小熊, 祐子, 八木, 紫, 真鍋, 知宏, 石田, 浩之, 勝川, 史憲, 大谷, 俊郎

日本臨床スポーツ医学会誌 19 ( 4 ) S133 2011.10

ISSN 1346-4159

齋藤, 義信, 小熊, 祐子, 井上, 茂, 田中, あゆみ, 頼, 建豪, 小川, 芳弘, 高橋, 健, 鈴木, 清美, 小堀, 悦孝

運動疫学研究: Research in Exercise Epidemiology 13 ( 2 ) 125 - 136 2011.09

ISSN 1347-5827

藤沢市国民健康保険被保険者を対象に行った質問紙調査から、移動における歩行および余暇活動におけるウォーキングと環境要因との関連を検討した。特定健康診査と質問紙調査の結果が得られた60〜69歳の1917例を対象とした。肥満者の割合は、男性26.8%、女性15.3%であった。平均的な1週間で、週に1回以上かつ1回につき少なくとも10分間以上続けて歩行を行っている者は、移動における歩行では男性74.9%、女性81.5%で、余暇活動のウォーキングでは男性67.6%、女性63.7%であった。移動における歩行と有意に関連する自宅周辺の環境要因は、男女共通して、近所にスーパーや商店があること、歩道があること、自動車・オートバイを所有していないことであった。余暇活動のウォーキングと有意に関連する自宅周辺の環境要因は、男女共通して、近所で運動実施者を見かけること、近所の景観が良いことであった。

Effects of resistance training with whole-body vibration on muscle fitness in untrained adults

Osawa Y., Oguma Y.

Scandinavian journal of medicine & science in sports 2011.08

Research paper (scientific journal), Joint Work, Accepted

Effects of Whole-body Vibration on Resistance Training for Untrained Adults.

Osawa Y., Oguma Y.

Journal of Sports Science and Medicine 10 ( 2 ) 328-337 2011.06

Research paper (scientific journal), Joint Work, Accepted

2型糖尿病者の罹病期間が運動耐容能に及ぼす影響の検討

東, 宏一郎, 河合, 俊英, 小熊, 祐子, 石田, 浩之, 勝川, 史憲, 伊藤, 裕, 松本, 秀男

糖尿病 54 ( Suppl.1 ) S - 348 2011.04

ISSN 0021-437X

血中脂肪酸分画と体脂肪分布、経口糖負荷試験(OGTT)時の各指標との関連

河合, 俊英, 小熊, 祐子, 勝川, 史憲, 広瀬, 寛, 田中, 久美子, 目黒, 周, 税所, 芳史, 東, 宏一郎, 松本, 秀男, 伊藤, 裕

糖尿病 54 ( Suppl.1 ) S - 294 2011.04

ISSN 0021-437X

中高年者における日常身体活動および健康関連指標と環境要因との関係　藤沢市における検討

齋藤, 義信, 小熊, 祐子 and 小堀, 悦孝

健康医科学研究助成論文集 ( 26 ) 1 - 14 2011.03

Research paper (scientific journal)

藤沢市で2009年に特定健診を受けた40〜69歳の国保被保険者の中から無作為抽出した4165名に質問紙調査を行い、活動的な移動手段としての歩行・自転車利用と環境要因との関係、メタボリックシンドローム(MeS)と環境要因との関係などについて検討した。2449名から回答が得られ、性別は男性1194名、女性1255名であった。検討の結果、活動的な移動手段としての歩行時間と有意な関連を示す環境要因として男女とも「住宅密度が高いこと」「近所にスーパーや商店があること」「歩道があること」「自動車・オートバイを所有していないこと」が抽出され、女性では「近所に運動場所があること」「近所で運動実施者を見かけること」も抽出された。自転車利用と有意な関連を示す環境要因は男女とも「自転車運転時の安全性(交通量)」が抽出され、男性では「近所に自転車道があること」「運動場所があること」「近所で運動実施者を見かけること」、女性では「自動車・オートバイを所有していないこと」も抽出された。MeS非該当に関連する環境要因として、男性で「自動車・オートバイを所有していないこと」、女性で「近所に自転車道があること」「近所で運動実施者を見かけること」「近所の景観が良いこと」が抽出された。

【高齢者の虚弱　評価と対策】虚弱高齢者に対する運動介入の効果

宮地, 元彦, 西脇, 祐司, 安藤, 大輔, 種田, 行男, 小熊, 祐子, 小野, 玲, 北畠, 義典, 田中, 喜代次, 道川, 武紘, 柳田, 昌彦, 吉村, 公雄 and 武林, 亨

Geriatric Medicine 49 ( 3 ) 319 - 322 2011.03

Research paper (scientific journal), Joint Work, ISSN 0387-1088

65歳以上の高齢者への「運動」介入が運動器の機能に関連するアウトカム改善に効果があるか否かについて、システマティックレビューを用いて検証した。高齢者に対する虚弱改善や介護予防において最も重要と考えたアウトカムであるADL、IADLを、運動介入によって改善させるか否かという視点では、効果を肯定的に示した文献数が少なく、一定の知見を得ることは困難と考えられた。しかし代理アウトカムでは、複合的な運動トレーニングにより転倒を減少させ得ること、十分な強度の筋力トレーニングであれば骨格筋量を増加させ得ること、特定の種目でなくとも十分な強度・頻度の運動介入により高齢者の膝痛の軽減が期待できること、が示唆された。(著者抄録)

【アンチエイジングを考える】若々しさを保つために　心肺機能の低下を防ぐ　心肺機能を維持するための身体活動について

小熊, 祐子

クリニシアン 58 ( 1 ) 48 - 55 2011.01

Research paper (scientific journal), ISSN 0387-1541

サルコペニアの臨床サルコペニアに対する治療の可能性　運動介入効果に関するシステマティックレビュー

宮地, 元彦, 安藤, 大輔, 種田, 行男, 小熊, 祐子, 小野, 玲, 北畠, 義典, 田中, 喜代次, 西脇, 祐司, 道川, 武紘, 柳田, 昌彦, 吉村, 公雄 and 武林, 亨

日本老年医学会雑誌 48 ( 1 ) 51 - 54 2011.01

Research paper (scientific journal), Joint Work, ISSN 0300-9173

サルコペニアの代替指標である骨格筋量に対する運動介入研究を検索し、サルコペニアの予防・改善のための適切な運動方法について検討した。一次検索により951本の論文が抽出され、うち選定された9論文を対象とした。5本は高強度筋力トレーニングが高齢者の骨格筋量を増加させるとしたものであった。3本は低・中強度筋力トレーニングは骨格筋に影響しないというものであった。骨格筋量を増加させるためには、最大挙上重量(1RM)の80%以上の強度で、1セット当たりの挙上回数が8〜12回の運動を2〜3セット、週3回、3ヵ月以上行う高強度筋力トレーニングを行う必要があることが示唆された

移動および余暇の歩行行動に関連する環境要因－藤沢市在住の60～69歳を対象とした横断研究－

齋藤義信, 小熊祐子, 井上茂, 田中あゆみ, 頼建豪, 小川芳弘, 高橋健, 鈴木清美 and 小堀悦孝

運動疫学研究 13 2 ( 2 ) 125 - 136 2011

Effects of Whole-body Vibration Training on Bone-Free Lean Body Mass and Muscle Strength in Young Adults

Osawa Y, OGUMA YUKO, Onishi S.

Journal of Sports Science and Medicine 10 ( 1 ) 97 - 104 2011

Research paper (scientific journal), Joint Work, Accepted

Effects of Whole-Body Vibration on Physiological Responses to One Bout of Resistance Training.

Osawa Y, OGUMA YUKO, Onishi S.

Journal of Exercise Physiology 14 ( 2 ) 36 - 45 2011

Research paper (scientific journal), Joint Work, Accepted

Treatment indications for sarcopenia: a systematic review of exercise intervention effect

Miyachi M, Ando D, Oida Y,OGUMA YUKO, Ono R, Kitabatake Y, Tanaka K, Nishiwaki Y, Michikawa T, Yanagita M, Yoshimura K, Takebayashi T.

Nihon Ronen Igakkai Zasshi 48 ( 1 ) 51-4 - 4 2011

Research paper (scientific journal), Joint Work, Accepted, ISSN 0300-9173

OBJECTIVE: To evaluate exercise intervention efficacy for the prevention and treatment of sarcopenia in the elderly. METHODS: We conducted a systematic literature search of randomized controlled trials in the Physical Activity Guidelines Advisory Committee Report (before 2007), Pubmed, the Cochrane database, and Igaku Chuo Zasshi (January 2006 to August 2009). DATA EXTRACTION: Two authors independently extracted relevant data. A total of 951 articles were found by search engines, and 9 studies were finally selected after a review by 2 experts. The content of these studies, especially duration, sets, periods, frequency, and intensity of exercise intervention were extracted and summarized in a results table. Five of 6 articles concluded that high-intensity resistance training significantly increased soft lean tissue and muscle mass. The remaining 3 articles indicated that moderate-intensity resistance training did not affect soft lean tissue or muscle mass. CONCLUSION: This systematic review suggested that high-intensity resistance training with sufficient periods, frequency, repetitions, and sets is effective to counteract the loss of muscle mass associated with advancing age.

Effects of whole-body vibration on resistance training for untrained adults

Osawa, Y. and Oguma, Y.

J Sports Sci Med 10 ( 2 ) 328 - 37 2011

ISSN 1303-2968

Although resistance training (RT) combined with whole-body vibration (WBV) is becoming increasingly popular among untrained adults, the additional effects of WBV on muscle fitness are still not well understood. The aim of the present study was to evaluate the effects of WBV on muscle strength, muscle power, muscle endurance, and neuromuscular activities compared with the identical RT without WBV. Thirty-three individuals (6 males and 27 females; 22-49 years old) were randomly assigned to a training program using slow-velocity RT coupled with WBV (RT- WBV group, n = 17) or an identical exercise program without WBV (RT group, n = 16). Participants performed eight exercises per 60 min session on a vibration platform (RT-WBV group, frequency, 35 Hz; amplitude, 2 mm) twice weekly for seven weeks. To evaluate the effects of WBV, the maximal isometric and isokinetic knee extension strength, maximal isometric lumbar extension strength, countermovement-jump, and the number of sit-ups were measured before and after the trial. Significantly higher increases were observed in the maximal isometric and concentric knee extension strength (p = 0.02, p = 0.04 , respectively), and maximal isometric lumbar extension strength at 60 degrees of trunk flexion (p = 0.02) in the RT-WBV group (+36.8%, +38.4%, +26.4%, respectively) in comparison to the RT group (+16.5%, +12.8%, +14.3%, respectively). A significant difference was also observed between the RT-WBV group (+8.4%) and the RT group (+4.7%) in the countermovement jump height (p = 0.02). In conclusion, the results suggest that significant additional increases in maximal isometric and concentric knee extension and lumbar extension strength, and countermovement jump height can be achieved by incorporating WBV into a slow-velocity RT program during the initial stage of regular RT in untrained healthy adults. Key pointsA randomized controlled trial was conducted to investigate the effects of slow velocity resistance training combined with whole-body vibration on maximal muscle strength, power, muscle endurance, and neuromuscular activities in healthy untrained individuals.Resistance training program for lower extremities and trunk muscles were performed twice weekly for 7 weeks.A 7 weeks slow velocity resistance training program with whole-body vibration significantly increased maximal isometric knee extension and lumbar extension strength and power in healthy untrained individuals.

Effects of whole-body vibration training on bone-free lean body mass and muscle strength in young adults

Osawa, Y., Oguma, Y. and Onishi, S.

J Sports Sci Med 10 ( 1 ) 97 - 104 2011

ISSN 1303-2968

Resistance training with whole-body vibration (WBV) is becoming increasingly popular as an alternative to conventional resistance training or as supplementary training. Despite its growing popularity, the specific effects of WBV training on muscle morphology, strength, and endurance are not well understood, particularly in young adults. The aim of this study was to determine the effects of WBV training on bone-free lean body mass (BFLBM), and maximal muscle strength and endurance in healthy, untrained, young individuals. Eighteen healthy men and women (21-39 years) were randomly assigned to either a body-weight exercise with WBV (VT) group or a control exercise group without WBV (CON). Participants performed eight exercises per 40- min session on a vibration platform (VT group, frequency = 30-40 Hz; amplitude = 2 mm) twice weekly for 12 weeks. Anthropometry, total and regional BFLBM (trunks, legs, and arms) measured by dual- energy X-ray absorptiometry, and muscle strength and endurance measured by maximal isometric lumbar extension strength, maximal isokinetic knee extension and flexion strength, and the number of sit- ups performed were recorded and compared. Two-way repeated-measures ANOVA revealed no significant changes between the groups in any of the measured variables. We conclude that 12 weeks of body weight vibration exercise compared to body weight exercise alone does not provide meaningful changes to BFLBM or muscle performance in healthy young adults. Key pointsA randomized controlled trial was conducted to investigate the effects of body-weight exercise combined with whole-body vibration on bone-free lean body mass and maximal muscle strength and endurance in healthy young individuals.Body-weight exercises for lower extremities and trunk muscles were performed twice weekly for 12 weeks.Participants in the exercise with whole-body vibration group increased the vibration frequency from 30, 35, to 40 Hz at a constant amplitude of 2 mm during the trial.A 12-week body-weight exercise program with whole-body vibration did not significantly increase bone-free lean body mass in healthy young individuals, and no additional increases in maximal muscle strength and endurance were observed.

【高齢者の虚弱　評価と対策】虚弱高齢者に対する運動介入の効果.

1. 宮地元彦, 西脇祐司, 安藤大輔, 種田行男, 小熊祐子, 小野玲, 北畠義典, 田中喜代次, 道川武紘, 柳田昌彦, 吉村公雄, 武林亨

Geriatric Medicine 49 ( 3 ) 319 - 322 2011

Research paper (scientific journal)

サルコペニアの臨床サルコペニアに対する治療の可能性　運動介入効果に関するシステマティックレビュー

2. 宮地元彦, 安藤大輔, 種田行男, 小熊祐子, 小野玲, 北畠義典, 田中喜代次, 西脇祐司, 道川武紘, 柳田昌彦, 吉村公雄, 武林亨

日本老年医学会雑誌 48 ( 1 ) 51 - 54 2011

【アンチエイジングとリハビリテーション】運動とアンチエイジング

小熊祐子

MEDICAL REHABILITATION 124 7 - 12 2010.11

Research paper (scientific journal), Single Work, ISSN 1346-0773

加齢に伴い、一般的に身体機能は低下する。定期的に体を動かすことが、健康的な加齢に好影響を及ぼすことが実証されている。心肺機能については、例えば最大酸素摂取量は、25歳以降10年で約10%低下する。活動量の多い人では減少が少なく、また高齢者でも、強度依存性にトレーニングにより増加しうる。筋力は60〜70歳代で10年間に約15%、それ以降では10年で約30%低下する。適切な負荷がかかれば、高齢者であっても筋力や筋量の増加が期待できる。日常のエネルギー消費量も加齢とともに低下するが、主たる原因は、加齢に伴う身体活動量の低下にある。定期的な身体活動や有酸素トレーニングにより、種々の生理機能・代謝指標・心理指標の改善を認めること、種々の慢性疾患や早期死亡のリスクを減少させることが、多くの実験的研究や疫学研究により幅広い年齢層で示されている。生涯の各時期で運動に取り組むことがアンチエイジングに寄与するといえよう。(著者抄録)

【エビデンスに基づいた運動療法・運動処方　健康支援・疾病予防に対するアプローチ】健康増進・疾病予防のための身体活動　エビデンスと推奨

小熊祐子

臨床スポーツ医学 27 ( 11 ) 1181 - 1186 2010.11

Research paper (scientific journal), Single Work, ISSN 0289-3339

呼気ガス分析より求めた無酸素閾値と50%予備心拍数で求めた目標心拍数の関係

東, 宏一郎, 田村, 雄一, 石川, 愛子, 石田, 浩之, 河合, 俊英, 小熊, 祐子, 勝川, 史憲, 松本, 秀男

日本臨床スポーツ医学会誌 18 ( 4 ) S168 2010.10

ISSN 1346-4159

ショートテニス運動中の運動強度についての検討中高齢者スポーツとしての可能性

原田, 昇, 小熊, 祐子

日本臨床スポーツ医学会誌 18 ( 4 ) S167 2010.10

ISSN 1346-4159

振動トレーニングによる筋力向上効果の検討健常成人を対象にした無作為化比較試験

大澤, 祐介, 八木, 紫, 小熊, 祐子

日本臨床スポーツ医学会誌 18 ( 4 ) S147 2010.10

ISSN 1346-4159

ボグリボース、ピオグリタゾンの12週間投与がOGTT時各指標に及ぼす効果の検討

田中久美子, 河合俊英, 武井泉, 島田朗, 石橋みどり, 平田匠, 東宏一郎, 小熊祐子, 税所芳史, 松本秀男, 伊藤裕

肥満研究 16 ( Suppl. ) 177 2010.09

ISSN 1343-229X

太極拳練習者の練習前後の脳波による感情測定「フロー体験」と「ストレス対処能力」に注目して

飯田健次, 小熊祐子

日本運動療法学会大会抄録集 35回 34 2010.07

【糖尿病診療の今後の展望　運動療法を効果的に取り込むには】糖尿病治療・予防におけるライフスタイル改善の意義　近年の疫学研究結果より

小熊祐子

臨床スポーツ医学 (東京) 27 ( 5 ) 479 - 485 2010.05

Research paper (scientific journal), Single Work, ISSN 0289-3339

ピオグリタゾン、ボグリボースの3ヵ月間投与の経口糖負荷試験(OGTT)時の各指標に及ぼす効果の比較検討

河合, 俊英, 武井, 泉, 島田, 朗, 石橋, みどり, 平田, 匠, 東, 宏一郎, 小熊, 祐子, 松本, 秀男, 伊藤, 裕

糖尿病 53 ( Suppl.1 ) S - 182 2010.04

ISSN 0021-437X

「メタボリックシンドロームとその予備群を対象とした介入プログラム」終了後の体重維持に及ぼす因子の検討自己効力感に着目して

頼建豪, 大澤祐介, 小熊祐子, 大西祥平, 八木紫, 橋本玲子, 勝川史憲

運動疫学研究: Research in Exercise Epidemiology 12 66 2010.03

ISSN 1347-5827

食のユニバーサルデザインと中学生の食育

小熊祐子, 山下光雄

東京都中学校食育推進委員会総会 2010.03

Research paper (other academic), Joint Work

新聞投書欄で語る"健康"を読み解く

篠原圭子, 小熊祐子 and 大西祥平

運動疫学研究: Research in Exercise Epidemiology 12 87 - 88 2010.03

ISSN 1347-5827

高齢者の健康保持能力とスポーツ・運動とのかかわり　藤枝市の高齢者を対象にしたアンケート調査より

中屋拓久, 高橋武則, 小熊祐子 and 大西祥平

運動疫学研究: Research in Exercise Epidemiology 12 40 - 41 2010.03

ISSN 1347-5827

高齢者の健康保持能力とスポーツ・運動とのかかわり　藤枝市の高齢者を対象にしたアンケート調査より

中屋, 拓久, 高橋, 武則, 小熊, 祐子 and 大西, 祥平

健康支援 12 ( 1 ) 85 2010.02

ISSN 1345-0174

新聞投書欄で語る"健康"を読み解く

篠原, 圭子, 小熊, 祐子 and 大西, 祥平

健康支援 12 ( 1 ) 113 2010.02

ISSN 1345-0174

運動ストレスへのラクトフェリン腸溶錠連続摂取の影響に関する研究

若林秀夫, 小熊祐子, 大西祥平

体力科学 59 ( 1 ) 186 2010.02

ISSN 0039-906X

TDS(Talent Diagnose System)を用いた運動能力測定の再現性について

藤井裕輔, 増田元長, 小熊祐子, 大西祥平

体力科学 58 ( 6 ) 845 2009.12

ISSN 0039-906X

30歳台女性の運動習慣とBMIおよび体脂肪率との関連藤沢市における検討

齋藤義信, 相馬純子, 鈴木清美, 小堀悦孝, 小熊祐子, 大西祥平

日本公衆衛生学会総会抄録集 68回 411 2009.10

ISSN 1347-8060

メタボリックシンドローム・その予備群における効率的なライフスタイル改善法の探索(第二報)

小熊, 祐子, 八木, 紫, 橋本, 玲子, 大澤, 祐介, 木下, 訓光, 勝川, 史憲 and 大西, 祥平

日本臨床スポーツ医学会誌 17 ( 4 ) S126 2009.10

ISSN 1346-4159

筋力トレーニングにおける振動刺激による漸増負荷に関する考察

大澤祐介, 小熊祐子, 山崎元, 大西祥平

日本臨床スポーツ医学会誌 17 ( 4 ) S160 2009.10

ISSN 1346-4159

生活習慣病予防のエビデンスと実際 ―運動・食事療法を中心にー

OGUMA YUKO

相和会講演会 2009.09

Research paper (other academic), Single Work

食のユニバーサルデザインと食育－誰でも簡単に理解し、実践できる－

OGUMA YUKO

東京都中学校食育推進委員会講演 2009.07

Research paper (other academic), Joint Work

【身体活動・運動と生活習慣病　運動生理学と最新の予防・治療】身体活動の評価　身体活動量の測定法　機器による身体活動の評価

大澤, 祐介 and 小熊, 祐子

日本臨床 67 ( 増刊2 身体活動・運動と生活習慣病 ) 149 - 153 2009.04

ISSN 0047-1852

機器による身体活動の評価身体活動・運動と生活習慣病－運動生理学と最新の予防・治療―

OGUMA YUKO

日本臨床 67 ( 増刊２ ) 149-153 - 153 2009.04

Research paper (scientific journal), Joint Work, ISSN 0047-1852

太極拳の健康への効果と継続要因について　継続年数の違いによる比較研究

飯田健次,小熊祐子,佐野毅彦, 大西祥平

運動療法と物理療法 19 ( 4 ) 332 - 339 2008.12

Research paper (scientific journal), Joint Work

メタボリックシンドローム・その予備群における効率的なライフスタイル改善法の探索(第1報)

小熊, 祐子, 八木, 紫, 橋本, 玲子, 大澤, 祐介, 木下, 訓光, 勝川, 史憲, 大西, 祥平 and 山崎, 元

日本臨床スポーツ医学会誌 16 ( 4 ) S119 2008.10

ISSN 1346-4159

ITを活用した中高年向け生活習慣改善プログラムにおける継続要因に関する検討

宮川祥子, 小熊祐子, 大澤繁男, 仰木裕嗣

日本公衆衛生学会総会抄録集 67回 244 2008.10

ISSN 1347-8060

スポーツによる鼠径部痛スポーツヘルニアに関する調査

若野紘一, 石橋秀幸, 今井丈, 小熊祐子, 大西祥平, 山崎元, 松本秀男, 竹田毅, 岩本潤

日本臨床スポーツ医学会誌 16 ( 4 ) S145 2008.10

ISSN 1346-4159

太極拳の健康への効果とその継続要因について継続年数の違いによる比較研究

飯田健次, 小熊祐子, 佐野毅彦, 大西祥平

日本運動療法学会大会抄録集 33回 18 2008.06

中高年向け生活習慣改善プログラム「インターネット健康コミュニティ」

宮川祥子, 仰木裕嗣, 大澤繁男, 山下光雄, 小熊祐子, 佐藤蓉子

ITヘルスケア 3 ( 1 ) 14 - 17 2008.05

Research paper (scientific journal), Joint Work, Accepted, ISSN 1881-4808

中高年を対象とした、ITを活用した生活習慣改善プログラム「インターネット健康コミュニティ」の概要とその効果について述べる。生活習慣改善は、長期に継続して取り組むこと、また本人が主体的に取り組むことが重要である。本プログラムのインターネットでの記録蓄積・コミュニケーションと対面型のコミュニケーションを併用しているという特徴は、食事・運動記録の蓄積によりセルフモニタリングが可能となること、対面でのコミュニケーションが継続的な記録の蓄積の原動力となりえることが示唆された。(著者抄録)

男子短距離選手の体幹および下肢筋群の筋力特性

丸田巖, 八木紫, 木下訓光, 勝川史憲, 小熊祐子, 大西祥平, 山崎元

体力科学 56 ( 6 ) 749 2007.12

ISSN 0039-906X

【慢性疾患に対する身体活動のすすめ方 QOL向上への新しい具体策】身体活動による慢性疾患の予防

小熊祐子

臨床スポーツ医学 24 ( 臨増 ) 2 - 10 2007.11

ISSN 0289-3339

【慢性疾患に対する身体活動のすすめ方 QOL向上への新しい具体策】週末戦士(ウイークエンドワリアー)

小熊祐子

臨床スポーツ医学 24 ( 臨増 ) 118 - 120 2007.11

ISSN 0289-3339

【慢性疾患に対する身体活動のすすめ方 QOL向上への新しい具体策】癌と身体活動

小熊祐子

臨床スポーツ医学 24 ( 臨増 ) 67 - 68 2007.11

ISSN 0289-3339

バイブレーション・トレーニングの運動強度についての検討酸素摂取量および脈拍を指標に

大澤祐介, 小熊祐子, 大西祥平, 山崎元

日本臨床スポーツ医学会誌 15 ( 4 ) S147 2007.10

ISSN 1346-4159

100球連続投球後のアイシング効果についての検討

石橋秀幸, 若野紘一, 松本秀男, 桐山善守, 小熊祐子, 大西祥平, 山崎元

日本臨床スポーツ医学会誌 15 ( 4 ) S193 2007.10

ISSN 1346-4159

100球連続投球における肘・肩関節周囲筋の疲労の検討競技レベルの違いと筋放電量の関係

石橋秀幸, 大西祥平, 小熊祐子, 若野紘一, 桐山善守, 松本秀男, 山崎元

日本臨床スポーツ医学会誌 15 ( 4 ) S154 2007.10

ISSN 1346-4159

小熊祐子

臨床スポーツ医学 24 ( 8 ) 869 - 876 2007.08

ISSN 0289-3339

バイブレーション・トレーニングの身体組成への効果を検証する無作為化比較試験

大澤祐介, 小熊祐子, 八木紫, 佐野毅彦, 大西祥平

日本運動療法学会大会抄録集 32回 A1 2007.06

ラクトフェリン腸溶錠摂取の運動ストレスへの急性効果についての検討

若林秀夫, 小熊祐子, 佐野毅彦, 大西祥平

日本運動療法学会大会抄録集 32回 B5 2007.06

ANTI-AGING MEDICINE　サイエンスとしての運動とアンチエイジング

小熊祐子

アンチ・エイジング医学 3 ( 2 ) 203 - 209 2007.05

ISSN 1880-1579

癌と身体活動

小熊祐子

臨床スポーツ医学 24 ( 2 ) 199 - 205 2007.02

ISSN 0289-3339

サイエンスとしての運動とアンチエイジング

小熊祐子

アンチ・エイジング医学 3 ( 2 ) 203 - 209 2007

身体活動による慢性疾患の予防

小熊祐子

臨床スポーツ医学 24 ( 臨時増刊号 ) 2 - 10 2007

癌と身体活動

小熊祐子

臨床スポーツ医学 24 ( 臨時増刊号 ) 67 - 68 2007

週末戦士（ウィークエンドワリアー）

小熊祐子

臨床スポーツ医学 24 ( 臨時増刊号 ) 118 - 120 2007

加速度計を用いた身体活動量の測定　種々の対象群についての検討

小熊, 祐子, 木下, 訓光, 勝川, 史憲, 大西, 祥平 and 山崎, 元

日本臨床スポーツ医学会誌 14 ( 4 ) S146 2006.10

ISSN 1346-4159

健康増進・疾病予防のためのphysical activity　疫学研究からのエビデンスと実際

小熊, 祐子

日本運動療法研究会抄録集 ( 31回 ) 15 2006.07

ISSN 1347-9113

【スポーツ医学の新展開】　癌の予防としての身体活動

小熊, 祐子

医学のあゆみ 217 ( 11 ) 1025 - 1028 2006.06

ISSN 0039-2359

身体活動量と癌(または癌死亡)のリスクの関連については,ここ30年ほどの間に多くの疫学研究(おもに観察研究:症例対照研究およびコホート研究)がなされてきた.この関連の程度は癌の部位により異なり,一部の癌に関しては,疫学研究の関連の一貫性,関連の強さ,容量・反応関係および考えられる機序をもとにエビデンスが確立されてきている.結腸癌および乳癌(女性)では身体活動量との関連は確実で,活動量がもっとも多い群はもっとも少ない群と比較し,前者で30〜40%,後者で20〜30%のリスク減を認めている.前立腺癌では確定的ではないが,10%程度のリスク減を認めている.肺癌,子宮内膜癌については検討数が少ないが,リスク減の可能性がある.その他の癌については研究報告が少ない.癌の一次予防を目的とする身体活動量の目安として大人では中等度の身体活動を30分以上,週に5日以上行うことが推奨されている(著者抄録)

Gender differences in effects of physical activity on quality of life and resource utilization.

Morimoto T, OGUMA YUKO, Yamazaki S, Sokejima S, Nakayama T, Fukuhara S

Quality Life Research 15 ( 3 ) 537 - 546 2006.03

Research paper (scientific journal), Joint Work, Accepted, ISSN 0962-9343

BACKGROUND: Physical activity is associated with health-related quality of life (HRQOL) in the general population, but the effects may be different between sexes. In addition, the effects on resource utilization are not well elucidated. METHODS: A population-based cross-sectional survey was conducted in a rural town, and follow-up data were obtained after 1 year. Physical activity was measured in two ways: amount and maximum intensity. The association between physical activity and the MOS Short Form-36 (SF-36) at baseline, and hospitalization, sick days, and medications in the following year were assessed by multiple regression models. RESULTS: Among 4018 adult residents eligible, 3529 (62.4%) had completed the follow-up questionnaire. A greater amount of exercise was positively correlated with all domains of the SF-36: 2.4-9.5 increase in 100-scale at baseline, but association between maximum intensity and SF-36 was observed in only women. It was also associated with a 20-50% higher utilization of over-the-counter drugs in the following year in both sexes, but the effects of maximum intensity on sick days had different directions for men (relative risk, 2.0-2.4) and women (relative risk, 0.3-0.5). CONCLUSION: The amount of physical activity had positive effects on HRQOL for both men and women, but women had more preferable effects of maximum intensity on HRQOL and resource utilization than men.

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スポーツ医学エビデンス　身体活動で疾病は予防・改善可能か?　身体活動量と総死亡率

小熊祐子

臨床スポーツ医学 23 ( 2 ) 189 - 198 2006.02

ISSN 0289-3339

スポーツ医学エビデンス　身体活動で疾病は予防・改善可能か?　身体活動量と総死亡率

小熊, 祐子

臨床スポーツ医学 23 ( 2 ) 189 - 198 2006.02

ISSN 0289-3339

健康増進・疾病予防のためのphysical activity-疫学研究からのエビデンスと実際

小熊祐子

31st 15 2006

Physical activity

Lee, I-Min and Oguma, Yuko

(Oxford Univ Press) 449 - 467 2006

身体活動量と総死亡率

小熊祐子

臨床スポーツ医学 23 ( 2 ) 189 - 198 2006

スポーツ医学の新展開癌の予防としての身体活動

小熊祐子

217 1025 - 1028 2006

身体活動量と癌(または癌死亡)のリスクの関連については,ここ30年ほどの間に多くの疫学研究(おもに観察研究:症例対照研究およびコホート研究)がなされてきた。この関連の程度は癌の部位により異なり,一部の癌に関しては,疫学研究の関連の一貫性,関連の強さ,容量・反応関係および考えられる機序をもとにエビデンスが確立されてきている。結腸癌および乳癌(女性)では身体活動量との関連は確実で,活動量がもっとも多い群はもっとも少ない群と比較し,前者で30-40%,後者で20-30%のリスク減を認めている。前立腺癌では確定的ではないが,10%程度のリスク減を認めている。肺癌,子宮内膜癌については検討数が少ないが,リスク減の可能性がある。その他の癌については研究報告が少ない。癌の一次予防を目的とする身体活動量の目安として大人では中等度の身体活動を30分以上,週に5日以上行うことが推奨されている。 (著者抄録)

スポーツ医学エビデンス身体活動で疾病は予防・改善可能か? 身体活動量と総死亡率

小熊祐子

23 189 - 198 2006

【高齢社会における運動支援実践ガイド】　実践　運動処方と運動指導　高齢者の運動処方・運動指導の注意点　内科的疾患がある場合　肥満

小熊祐子

臨床スポーツ医学 22 ( 臨増 ) 176 - 183 2005.11

ISSN 0289-3339

高い強度の運動は脂肪利用に有効か?

佐々木誠一, 勝川史憲, 東宏一郎, 大西祥平, 小熊祐子, 木下訓光, 石田浩之, 島田朗 and 山崎元

肥満研究 11 ( Suppl. ) 129 2005.09

ISSN 1343-229X

海外レビュー Physical activity/exercise and type 2 diabetes (2)

OGUMA YUKO

臨床スポーツ医学 22 ( 9 ) 1185 - 1198 2005.09

Research paper (scientific journal), Joint Work

空腹時インスリン値と各種血管障害指標との関連

河合俊英, 武井泉, 堀米ちひろ, 石橋みどり, 田畑光久, 小熊祐子 and 村田満

肥満研究 11 ( Suppl. ) 191 2005.09

ISSN 1343-229X

海外レビュー Physical activity/exercise and type 2 diabetes (1)

OGUMA YUKO

臨床スポーツ医学 23 ( 8 ) 1053 - 1062 2005.08

Research paper (scientific journal), Joint Work

Weight change and risk of developing type 2 diabetes

Oguma, Y., Sesso, H. D., Paffenbarger, R. S., Jr. and Lee, I. M.

Obes Res 13 ( 5 ) 945 - 951 2005.05

Research paper (scientific journal), Joint Work, Accepted, ISSN 1071-7323

OBJECTIVE: To examine the association between weight change and risk of type 2 diabetes and whether initial weight modifies the association. RESEARCH METHODS AND PROCEDURES: This is a prospective cohort study of 20,187 alumni from Harvard University and the University of Pennsylvania. At baseline in 1962 or 1966, men (mean age, 45.9 years) reported their weight, height, and other risk factors. They also had had their weight and height measured at university entry (mean age, 18.5 years). Participants were followed from baseline to 1998 for type 2 diabetes. RESULTS: During follow-up, 1223 men developed type 2 diabetes. Weight gain significantly increased the risk of this disease. The multivariate relative risks associated with BMI change from university entry to baseline of <-0.5, +/-0.5, >0.5 to 1.0, >1.0 to 1.5, >1.5 to 2.0, >2.0 to 3.0, and >3.0 kg/m(2) per decade were 0.88, 1.00 (referent), 1.29, 2.09, 2.69, 4.67, and 7.02, respectively (p for trend < 0.0001). Even among men with a low initial BMI < 21 kg/m(2), weight gain significantly increased risk; the corresponding relative risks were (no cases), 1.00 (referent), 1.00, 1.93, 2.47, 4.82, and 7.68, respectively (p for trend < 0.0001). DISCUSSION: A low initial BMI does not ameliorate the increase in risk of type 2 diabetes with weight gain. Avoidance of weight gain, even among lean individuals, is important to reduce the risk of this disease.

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若年成人肥満者におけるMetabolic Fitnessと減量に伴う改善効果

勝川史憲, 小熊祐子, 木下訓光, 大西祥平 and 山崎元

体力科学 54 ( 1 ) 67 - 68 2005.02

ISSN 0039-906X

成人肥満者(18〜39歳)についてmetabolicなリスクを評価し,年齢やBMI,性差の影響,ピーク酸素摂取量の関与,さらに食事プラス運動療法による生活習慣改善による減量が及ぼす改善効果を検討した.肥満者550例を対象とした.若年成人肥満者では,高インスリン血症を特徴的に認め,耐糖能異常よりも早期に脂質代謝異常,高血圧症が発現した.BMIが5増加,または年齢が10歳上昇すると,metabolic syndromeスコアはそれぞれ0.6および0.4増加した.metabolic syndromeの頻度は,BMI 25〜29.9では年齢とともに増加したが,BMI≧30では20代後半から高く,男性70%台,女性50%台であった.Peak V02/kgは,体重とは独立してmetabolic syndromeスコアの減少と関連していた.生活習慣修正による減量の程度に応じて,各種代謝指標が改善した.10%程度の軽度の減量でもMSの頻度は52から21%へと大きく減少した

スポーツ医学エビデンスー身体活動で疾病は予防・改善するか？第二回総死亡(all-cause mortality)

小熊祐子

臨床スポーツ医学 (文光堂) 23 ( 2 ) 189-198 2005.02

Research paper (scientific journal), Single Work

スポーツ医学エビデンスー身体活動で疾病は予防・改善するか？第一回連載にあたって

小熊祐子

臨床スポーツ医学 23 ( 1 ) 51-57 2005.01

Research paper (scientific journal), Single Work

空腹時インスリン値と各種血管障害指標との関連

河合俊英, 田畑光久, 武井泉, 石橋みどり, 村田満, 堀米ちひろ and 小熊祐子

11 191 2005

高い強度の運動は脂肪利用に有効か?

佐々木誠一, 東宏一郎, 島田朗, 勝川史憲, 大西祥平, 小熊祐子, 木下訓光, 石田浩之 and 山崎元

11 129 2005

その2:若年成人肥満者におけるMetabolic Fitnessと減量に伴う改善効果

勝川史憲, 小熊祐子, 木下訓光, 大西祥平 and 山崎元

54 67 - 68 2005

代謝反応ネットワークの構造特性解析に関する研究

小熊祐子, 吉井伸一郎, 嘉数ゆき昇 and 川上敬

2005 2A1 - S-067 2005

本研究では生体内の代謝反応をネットワークとしてモデリングし,その特性を検証することにより,代謝ネットワークの新しい性質の発見を試みる。そこで我々は,大腸菌およびH.B.Pyloriに関する代謝反応に対して,5種類のネットワークモデルで特性解析を行い,ネットワークとしての見方により性質がどのように異なるかを解明することを目的とする。解析結果から,スケールフリーネットワークが現れるモデルと現れないモデルがあることが分かった。スケールフリーネットワークが現れるモデルは長い進化過程をかけて生き残った物質が関わっていることがわかった。 (著者抄録)

III 実践-運動処方と運動指導- 6 高齢者の運動処方・運動指導の注意点 c.内科的疾患がある場合-肥満

小熊祐子 and 小熊祐子

22 176 - 183 2005

肥満がある高齢者に対する運動処方・運動指導の注意点について,以下の項目別に述べた。1)高齢者における疾病の概要-肥満と肥満症,2)年齢とボディマスインデックス(BMI)分布,3)高齢者の肥満と肥満症,4)減量の必要性をどう捉えるか?,5)実際の指導のポイント,6)メディカルチェックと介入前検査,7)何をどれくらい?-運動の種類と量の目安,8)レジスタンストレーニング,9)継続のためには。

身体活動・運動と2型糖尿病

田畑光久, 小熊祐子 and 小熊祐子

22 1185 - 1198 2005

身体活動と2型糖尿病の予防について概説した。始めに,2型糖尿病における有酸素フィットネスと有酸素運動として,2型糖尿病患者への血糖及び体重への系統だった運動による介入の効果,身体活動・有酸素フィットネスと心血管危険率及び総死亡率,運動の頻度,及び減量や体重維持目的の運動について解説した。次に,レジスタンス運動として,2型糖尿病患者におけるレジスタンス運動の研究,レジスタンストレーニングの安全性,及び柔軟運動について述べた。さらに,血糖コントロール不良時の運動,及び糖尿病慢性合併症存在下での運動について解説した。最後に,2型糖尿病と運動についての新しいアメリカ糖尿病学会指針と2000年のアメリカスポーツ医学会指針の比較について述べた。

【スポーツ医学検査測定ハンドブック】　検体検査　生化学検査　血清浸透圧

小熊祐子

臨床スポーツ医学 21 ( 臨増 ) 349 - 351 2004.12

ISSN 0289-3339

【スポーツ医学検査測定ハンドブック】　検体検査　生化学検査　血清浸透圧

小熊, 祐子

臨床スポーツ医学 21 ( 臨増 ) 349 - 351 2004.12

ISSN 0289-3339

若年成人肥満者のmetabolicなリスクの検討

勝川史憲, 小熊祐子, 木下訓光, 大西祥平, 山崎元 and 佐々木誠一

肥満研究 10 ( Suppl. ) 185 2004.09

ISSN 1343-229X

身体的フィットネスとmetabolic syndrome　若年〜中年成人肥満者での検討

佐々木誠一, 勝川史憲, 東宏一郎, 小熊祐子, 木下訓光, 石田浩之, 成田和穂, 大西祥平 and 山崎元

日本臨床スポーツ医学会誌 12 ( 4 ) S80 2004.09

ISSN 1346-4159

身体的フィットネスとmetabolic syndrome　肥満男子大学生での検討

勝川史憲, 佐々木誠一, 小熊祐子, 木下訓光, 石田浩之, 成田和穂, 大西祥平 and 山崎元

日本臨床スポーツ医学会誌 12 ( 4 ) S80 2004.09

ISSN 1346-4159

【内臓脂肪・皮下脂肪と運動】　食事療法による内臓脂肪、皮下脂肪の変化

小熊祐子

臨床スポーツ医学 21 ( 7 ) 747 - 752 2004.07

Research paper (scientific journal), Single Work, ISSN 0289-3339

The “Weekend Warrior” and risk of mortality

Lee, I. M., Sesso, H. D., Oguma, Y. and Paffenbarger, R. S., Jr.

American Journal of Epidemiology 160 ( 7 ) 636 - 641 2004.07

Research paper (scientific journal), Joint Work, ISSN 0002-9262

Physical activity improves health, and current recommendations encourage daily exercise. However, little is known about any health benefits associated with infrequent bouts of exercise (e.g., 1-2 episodes/week) that generate the recommended energy expenditure. The authors conducted a prospective cohort study among 8,421 men (mean age, 66 years) in the Harvard Alumni Health Study, without major chronic diseases, who provided details about physical activity on mailed questionnaires in 1988 and 1993. Men were classified as "sedentary" (expending <500 kcal/week), "insufficiently active" (500-999 kcal/week), "weekend warriors" (>/=1,000 kcal/week from sports/recreation 1-2 times/week), or "regularly active" (all others expending >/=1,000 kcal/week). Between 1988 and 1997, 1,234 men died. The multivariate relative risks for mortality among the sedentary, insufficiently active, weekend warriors, and regularly active men were 1.00 (referent), 0.75 (95% confidence interval (CI): 0.62, 0.91), 0.85 (95% CI: 0.65, 1.11), and 0.64 (95% CI: 0.55, 0.73), respectively. In stratified analysis, among men without major risk factors, weekend warriors had a lower risk of dying, compared with sedentary men (relative risk = 0.41, 95% CI: 0.21, 0.81). This was not seen among men with at least one major risk factor (corresponding relative risk = 1.02, 95% CI: 0.75, 1.38). These results suggest that regular physical activity generating 1,000 kcal/week or more should be recommended for lowering mortality rates. However, among those with no major risk factors, even 1-2 episodes/week generating 1,000 kcal/week or more can postpone mortality.

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Physical activity decreases cardiovascular disease risk in women.

Oguma Y, Shinoda-Tagawa T

American Journal of Preventive Medicine 26 ( 5 ) 2004.06

Research paper (scientific journal), Joint Work

肥満者におけるレジスチンと運動耐容能の検討

東宏一郎、勝川史憲、小口修司、佐々木誠一、小熊祐子、成田和穂、木下訓光、石田浩之、大西祥平、山崎元、島田朗、猿田享男

日本臨床スポーツ医学会誌 12 ( 2 ) 260-265 2004.02

Research paper (scientific journal), Joint Work

第7章検体検査　6生化学検査　ｈ血清浸透圧

小熊祐子

臨スポーツ医 21 ( S ) 349-351 2004

Research paper (scientific journal), Single Work

検体検査 6.生化学検査 h.血清浸透圧

小熊祐子

21 349 - 351 2004

特集内臓脂肪・皮下脂肪と運動食事療法による内臓脂肪,皮下脂肪の変化

小熊祐子

21 747 - 752 2004

食事療法による内臓脂肪,皮下脂肪の変化に関する代表的な近年の研究結果について,以下の項目別に紹介した。食事療法による内臓脂肪の変化に関する文献のまとめを表示した。1)Rossらの研究(2000),2)Rossらの研究(1996),3)Janssenの研究(2002),4)Nicklasらの研究(2003),5)Goodpasterの研究(1999),6)まとめ-減量法の如何にかかわらず,減量時の内臓脂肪量の減少率は,体重,総脂肪量,皮下脂肪量の減少率より大きかった,内臓脂肪を特異的に減少させる好ましい介入方法についてははっきりしなかった。

肥満者におけるレジスチンと運動耐容能の検討

東宏一郎, 佐々木誠一, 勝川史憲, 小熊祐子, 成田和穂, 木下訓光, 石田浩之, 大西祥平 and 小口修司

12 260 - 265 2004

男性13名,女性25名の非糖尿病肥満者を対象に,運動耐容能と糖負荷試験での血糖,インスリン,体組成,体脂肪分布との関連について検討し,レジスチン血中濃度を測定した。運動耐容能の指標としての負荷試験中の運動継続時間体組成と相関したが,インスリン抵抗性との相関は明らかではなく,レジスチン血中濃度とも相関しなかった。レジスチン血中濃度はインスリン抵抗性の指標,体組成とも相関がなかった。

Lack of association between tea and cardiovascular disease in college alumni

Sesso, H. D., Paffenbarger, R. S., Jr., Oguma, Y. and Lee, I. M.

Int J Epidemiol 32 ( 4 ) 527 - 33 2003.08

ISSN 0300-5771

BACKGROUND: Epidemiological studies suggest that tea intake, a major dietary source of flavonoids, may be associated with a decreased risk of cardiovascular disease (CVD). METHODS: We prospectively followed 17 228 subjects (mean age, 59.5 years) initially free of CVD and cancer from the College Alumni Health Study. Participants provided baseline self-reports of tea consumption (cups/day) and coronary risk factors. During a median follow-up of 15 years, there were 3372, 2615, and 757 cases of CVD, coronary heart disease (CHD), and stroke, respectively, ascertained from either self-reports or death certificates. RESULTS: Overall, the median level of tea consumption was 1 cup/day. Compared with participants consuming no tea, the multivariate relative risks (RR) of CVD for those drinking <1, 1, 2, 3, and >/=4 cups/day were 0.99, 0.96, 0.95, 0.91, and 0.95, respectively (P, trend = 0.19). The multivariate RR were 0.97, 0.98, 0.93, 0.85, and 0.98 for CHD (P, trend = 0.25), and 1.05, 0.89, 1.00, 1.09, and 0.83 for stroke (P, trend = 0.53). There was no evidence of effect modification. Changes in tea intake were assessed in a subgroup of 7730 men, with those continuing to drink tea having a non-significant 33% reduction in the risk of stroke. CONCLUSIONS: Tea intake, likely consumed as black tea, was not strongly associated with a reduced risk of CVD in this population of US college alumni.

高齢女性における身体活動量と総死亡率との関連　大学卒業生前向きコホート研究

小熊, 祐子, Sesso, Howard D., Paffenbarger, Jr Ralph S., 山崎, 元 and Lee, I-Min

日本更年期医学会雑誌 11 ( 1 ) 34 - 41 2003.04

ISSN 0919-5033

1980年に心血管系疾患・癌(メラノーマ以外の皮膚癌を除く)に罹患していなかったペンシルバニア大学卒業生女性1123例を1995年まで追跡し,高齢女性における身体活動量と総死亡率との関連を検討した.身体活動量は総死亡率と負の関連が認められた.特に,1日に12ブロック(1マイル相当)以上歩行していた女性は追跡期間中死亡する危険度が4ブロック未満の女性に比し31%低かった.高齢女性において,中等度の強度の身体活動でも死亡率低下につながることが示唆された

Unusual left ventricular dilatation without functional or biochemical impairment in normotensive extremely overweight Japanese professional sumo wrestlers

Kinoshita, N., Onishi, S., Yamamoto, S., Yamada, K., Oguma, Y., Katsukawa, F. and Yamazaki, H.

Am J Cardiol 91 ( 6 ) 699 - 703 2003.03

ISSN 0002-9149

To explore the physiologic limit of left ventricular (LV) enlargement, we performed echocardiography and air displacement plethysmography to respectively assess LV dimension and function and the body composition of Japanese professional sumo wrestlers. After excluding subjects with cardiovascular disease, hypertension, plasma brain natriuretic peptide (BNP) > or =17.9 pg/ml, diabetes mellitus, or asthma, 331 subjects (mean +/- SD age, 21.6 +/- 3.7 years; height 179.2 +/- 5.3 cm; weight 1,17.9 +/- 21.5 kg; percent fat, 29.6 +/- 6.6%) were analyzed. LV end-diastolic dimension averaged 58.4 +/- 3.7 mm and was within the generally regarded normal limit (< or =54 mm) in 14.5% of subjects, but was > or =60 mm in 41.1% of subjects. LV septal and posterior wall thicknesses were 10.3 +/- 0.9 and 10.2 +/- 0.9 mm, respectively. Peak E- and A-wave velocities, E/A ratio, LV fractional shortening, and BNP were 96 +/- 16 and 51 +/- 13 cm/s, 2.0 +/- 0.7, 33.5 +/- 4.5%, and 3.1 +/- 3.7 pg/ml, respectively. LV end-diastolic dimension was not correlated with these indexes of LV function or with plasma BNP levels, but was significantly correlated with height, weight, body surface area, fat-free mass, and fat mass. These results show that among very large, highly trained, professional athletes, LV end-diastolic dimension frequently exceeds the traditionally accepted upper limit of normal for the general population. This increase in LV end-diastolic dimension may thus represent an extreme example of the physiologic adaptation of the athlete's heart.

Physical activity, body weight, and pancreatic cancer mortality

Lee, I. M., Sesso, H. D., Oguma, Y. and Paffenbarger, R. S., Jr.

Br J Cancer 88 ( 5 ) 679 - 83 2003.03

ISSN 0007-0920

Relative intensity of physical activity and risk of coronary heart disease

Lee, I. M., Sesso, H. D., Oguma, Y. and Paffenbarger, R. S., Jr.

Circulation 107 ( 8 ) 1110 - 6 2003.03

ISSN 1524-4539

BACKGROUND: Current recommendations prescribe at least moderate-intensity physical activity, requiring >or=3 METs (metabolic equivalents) for >or=30 minutes almost daily, generating approximately 1000 kcal/wk. Defining intensity using an absolute scale in METs may be limited because it neglects variations in physical fitness: an activity requiring a particular MET value commands greater physical effort among less fit than more fit persons. It is unknown whether moderate-intensity exercise, relative to an individual's capacity, is associated with reduced coronary heart disease (CHD) rates. METHODS AND RESULTS: We followed 7337 men (mean age, 66 years) from 1988 to 1995. At baseline, men reported their actual activities and, using the Borg Scale, the perceived level of exertion when exercising (relative intensity). During follow-up, 551 men developed CHD. After multivariate adjustment, the relative risks of CHD among men who perceived their exercise exertion as "moderate," "somewhat strong," and "strong" or more intense were 0.86 (95% confidence interval, 0.66 to 1.13), 0.69 (0.51 to 0.94), and 0.72 (0.52 to 1.00), respectively (P(trend)=0.02), compared with "weak" or less intense. This inverse association extended to men not fulfilling current recommendations, ie, expending <1000 kcal/wk in physical activity or not engaging in activities of >or=3 METs (P(trend)=0.03 and 0.007, respectively). CONCLUSIONS: There is an inverse association between relative intensity of physical activity (an individual's perceived level of exertion) and risk of CHD, even among men not satisfying current activity recommendations. Recommendations for "moderate"-intensity physical activity may need to consider individual fitness levels instead of globally prescribing activities of >or=3 METs.

高齢女性における身体活動量と総死亡率との関連―大学卒業生前向きコホート研究―　

日本更年期医学会雑誌 11 34-41 2003

Research paper (scientific journal), Joint Work

Relative intensity of physical activity and risk of coronary heart disease.

Lee IM, Sesso HD, Oguma Y, Paffenbarger RSJr

Circulation 107 1110-1116 2003

Research paper (scientific journal), Joint Work

Physical activity, body weight, and pancreatic cancer mortality.

Lee IM, Sesso HD, Oguma Y, Paffenbarger RSJr

British Journal of Cancer 88 679-683 2003

Research paper (scientific journal), Joint Work

Lack of association between tea and cardiovascular disease in college alumni.

Sesso HD, Paffenbarger RSJr, Oguma Y, Lee IM

International Journal of Epidemiology 32 527-533 2003

Research paper (scientific journal), Joint Work

Unusual left ventricular dilatation without functional or biochemical impairment in normotensive extremely overweight Japanese professional Sumo wrestlers.

Kinoshita N, Onishi S, Yamamoto S, Yamada K, Oguma Y, Katsukawa F, Yamazaki H

American Journal of Cardiology 91 699-703 2003

Research paper (scientific journal), Joint Work

【生活習慣病の予防と治療　運動・食事・薬物療法と効果的なコンビネーションの実際】　癌　身体活動と癌

小熊, 祐子

臨床スポーツ医学 19 ( 臨増 ) 275 - 280 2002.10

ISSN 0289-3339

運動療法の運動負荷時心筋酸素消費量抑制効果について　肥満・耐糖能異常者を対象として

成田, 和穂, 小熊, 祐子, 辻岡, 三南子, 石田, 浩之, 木下, 訓光, 勝川, 史憲, 大西, 祥平 and 山崎, 元

日本臨床スポーツ医学会誌 10 ( 4 ) S121 2002.09

ISSN 1346-4159

減量幅別にみた体組成,インスリン感受性,アディポサイトカインの変化

勝川史憲, 東宏一郎, 小口修司, 成田和穂, 小熊祐子, 木下訓光, 石田浩之, 福澤素子, 大西祥平 and 山崎元

肥満研究 8 ( Suppl. ) 136 2002.09

ISSN 1343-229X

Physical activity and all cause mortality in women: a review of the evidence

Oguma, Y., Sesso, H. D., Paffenbarger, R. S., Jr. and Lee, I. M.

British Journal of Sports Medicine 36 ( 3 ) 162 - １72 2002.06

Research paper (scientific journal), Joint Work, ISSN 0306-3674

Light wavelength dependency of mating activity in the Drosophila melanogaster species subgroup

Sakai, T., Isono, K., Tomaru, M., Fukatami, A. and Oguma, Y.

Genes Genet Syst 77 ( 3 ) 187 - １95 2002.06

ISSN 1341-7568

The action spectra of mating activity among the six species of the Drosophila melanogaster species subgroup were compared to understand how light wavelength affects mating activity. The species fell into three groups with respect to the action spectrum of mating activity. We chose one representative species from each of the three types for detailed study: D. melanogaster, D. sechellia and D. yakuba. The mating activities were investigated under three different light intensities of three monochromatic lights stimulus. Each species showed a unique spectral and intensity response. To know the evolutionary meaning of the light wavelength dependency of mating activity, we superimposed the type of action spectrum of mating activity in these six species on a cladogram. Mating inhibition under UV was conserved in evolution among these species. Furthermore we clarified that D. melanogaster showed low mating activity under UV because males courted less under UV.

電気的筋肉刺激(EMS)による筋力トレーニングの体組成に及ぼす効果の検討

成田和穂, 大西祥平, 勝川史憲, 大林千代美, 常川尚美, 八木紫, 河崎文恵, 小熊祐子 and 山崎元

51 694 2002

Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes.

Hirose H, Kawai T, Yamamoto Y, Taniyama M, Tomita M, Matsubara K, Okazaki Y, Ishii T, Oguma Y, Takei I, Saruta T

Metabolism: Clinical & Experimental 51 ( 3 ) 314 - 317 2002

Research paper (scientific journal), Joint Work

The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 +/- 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a stable dose of sulfonylurea (n = 3), were studied at baseline and after 3 months of pioglitazone treatment (30 mg/d). Body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum insulin, adiponectin, and lipid profile were measured. Also, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) at the umbilical level were determined by computed tomographic (CT) scanning. Mean blood pressure (109 +/- 14 to 101 +/- 10 mm Hg), FPG (8.6 +/- 1.4 to 7.0 +/- 1.0 mmol/L), serum insulin (54 +/- 11 to 30 +/- 8 pmol/L, P <.01 for all), and HbA1c (6.7 +/- 0.8 to 6.1% +/- 0.6%, P =.013) decreased significantly during 3 months of pioglitazone treatment. BMI (26.4 +/- 3.2 to 27.0 +/- 3.5 kg/m2), low-density lipoprotein (LDL) cholesterol (124 +/- 24 to 138 +/- 24 mg/dL) and SAT (155 +/- 69 to 179 +/- 81cm2, P <.05 for all) increased, while triglycerides and high-density lipoprotein (HDL) cholesterol did not change significantly after 3 months of pioglitazone treatment. Serum adiponectin level increased in all patients (4.8 +/- 1.7 to 14.4 +/- 2.1 microg/mL, P =.005). VAT tended to increase (165 +/- 38 to 180 +/- 46 cm2) and VAT/SAT ratio tended to decrease (1.2 +/- 0.3 to 1.1 +/- 0.3), but these differences did not reach statistical significance. These results suggest that pioglitazone exerts good glycemic and blood pressure control despite increased BMI and SAT in Japanese male patients with type 2 diabetes. It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level. Copyright 2002 by W.B. Saunders Company

身体活動量と癌

臨床スポーツ医学 19 275-280 2002

Research paper (scientific journal), Single Work

ボストン留学生活

臨床スポーツ医学 19 583-586 2002

Research paper (scientific journal), Single Work

スポーツドクターレポートボストン留学生活 Harvard School of Public Health

小熊祐子

19 583 - 586 2002

内分泌代謝(肥満や糖尿病)を専門とする内科医の私は,ボストンのハーバード公衆衛生大学院疫学科,College Alumni Health Studyの研究室に留学中である。当研究室の研究内容,ハーバード公衆衛生大学院の特徴について紹介した。当研究室では,physical activityと健康に関する研究を行っており,私自身の研究テーマは,女性におけるphysical activityと全死亡率の関係である。ハーバード公衆衛生大学院は,1909年に医学部に予防医学・衛生学講座ができたことから始まり,1922年にロックフェラー財団の援助により医学部と隣接して大学院として設立された。私が受講しているコースの必修コースとして,疫学・生物統計学の他に公衆衛生倫理学,環境保健学,健康・社会行動科学のクラスがある。

年齢別に見た若年成人肥満者の体組成,代謝指標の断面的比較

勝川, 史憲, 東, 宏一郎, 小熊, 祐子, 成田, 和穂, 木下, 訓光, 辻岡, 三南子, 福澤, 素子, 大西, 祥平 and 山崎, 元

肥満研究 7 ( Suppl. ) 158 2001.09

ISSN 1343-229X

食事調査のunderreportingに及ぼす肥満の影響　doubly labelled water(DLW)を用いた検討の文献的解析

勝川, 史憲, 山下, 光雄, 東, 宏一郎, 小熊, 祐子, 成田, 和穂, 木下, 訓光, 石田, 浩之, 大西, 祥平 and 山崎, 元

肥満研究 7 ( Suppl. ) 147 2001.09

ISSN 1343-229X

心拍同時記録３次元加速時計を用いた活動強度と身体活動量の評価?1）基礎的検討．

1999年度慶應義塾大学スポーツ医学研究センター紀要 2001.01

Research paper (bulletin of university, research institution), Joint Work

Fortuitously discovered persistent left superior vena cava in young competitive athletes. Clinical implications of sports physicians.

Kinoshita N, Hasegawa K, Oguma Y, Katsukawa F, Onishi S, Yamazaki H

Journal of Sports Medicine and Physical Fitness 41 275 - 277 2001

Research paper (scientific journal), Joint Work

慢性腰痛症と日常生活との関連についての疫学的調査

八木, 紫, 大西, 祥平, 常川, 尚美, 大林, 千代美, 山本, 哲史, 小熊, 祐子, 木下, 訓光, 勝川, 史憲 and 山崎, 元

体力科学 49 ( 6 ) 806 2000.12

ISSN 0039-906X

Physiological profile of middle-aged and older climbers who ascended Gasherbrum II, an 8035-m Himalayan peak

Kinoshita, N., Yamazaki, H., Onishi, S., Oguma, Y., Katsukawa, F. and Horii, M.

J Gerontol A Biol Sci Med Sci 55 ( 11 ) M630 - 3 2000.11

ISSN 1079-5006

BACKGROUND: The purpose of this study was to investigate the physiological characteristics of a group of middle-aged and older Japanese climbers who ascended Gasherbrum II, an 8035-m peak in the Karakoram Range of the Himalayas. METHODS: Body composition, cardiac structure, and respiratory gas exchange during exercise were estimated in eight climbers with differing levels of experience (seven men and one woman, aged 54 to 63 years) 6 months before their expedition. RESULTS: Using supplementary O2, the four experienced climbers ascended beyond Camp 4 (7400 m) without showing any health problems and were able to attempt the summit. In contrast, the others, who had minimal experience at extreme altitude, suffered from altitude sickness on the way to Camp 4. Body mass index values were relatively high, but their low percentage of body fat (14.9%-21.4%) was indicative of the climbers' substantial lean body weight. Cardiac structures were generally normal, although three experienced male climbers had borderline hypertension and eccentric hypertrophy of the left ventricle. Peak VO2 ranged from 30.9 to 45.6 ml/kg/min, and no significant relationship between fitness level and the success or failure of the ascent was evident. CONCLUSIONS: Even sexagenarians are capable of safely climbing 8000-m peaks with supplementary O2. An exceptionally high fitness level, as is seen in elite older athletes, does not appear to be required. What is essential, however, is moderate fitness, good health, and extensive experience.

減量目標体重をどこに設定すべきか?　体組成の面からの検討

勝川, 史憲, 小熊, 祐子, 林, 啓介, 山本, 哲史, 木下, 訓光, 石田, 浩之, 福澤, 素子, 大西, 祥平 and 山崎, 元

肥満研究 6 ( Suppl. ) 106 2000.09

ISSN 1343-229X

除脂肪体重が多いと体脂肪は少ないか?　身体活動レベルと内容による差異

勝川, 史憲, 小熊, 祐子, 山本, 哲史, 木下, 訓光, 石田, 浩之, 大西, 祥平 and 山崎, 元

日本臨床スポーツ医学会誌 8 ( 4 ) S68 2000.09

ISSN 1346-4159

減量目標体重をどこに設定すべきか?　減量幅と体組成,代謝指標の観点から

勝川, 史憲, 小熊, 祐子, 山本, 哲史, 木下, 訓光, 石田, 浩之, 大西, 祥平, 山崎, 元 and 猿田, 享男

肥満研究 6 ( Suppl. ) 154 2000.09

ISSN 1343-229X

ライフスタイル修正が運動時の血圧に及ぼす効果　肥満・糖尿病患者を対象として

味村, 純, 小熊, 祐子, 辻岡, 三南子 and 山崎, 元

診断と治療 88 ( 8 ) 1371 - 1375 2000.08

ISSN 0370-999X

運動負荷試験を用いて,運動負荷時の血圧変化や心拍変化に対する1年間にわたる運動・食事療法の効果について検討した.対象は29例の男性であり,介入前より肥満やインスリン抵抗性および耐糖機能障害を有していた.介入後は体重・内臓脂肪の有意な減少と体脂肪率の減少傾向を認め,しかも除脂肪体重の維持と運動耐容時間の延長というフィットネスレベルの向上を示す結果を得た.血圧・心拍数の変化に対しては,日常生活における身体活動レベルに近い,軽い運動強度において,とくに血圧上昇反応を減少させる効果を認めた.対象はBMI・体脂肪率が高値であり,安静時血圧は高値を示さないものの,運動負荷試験前半を含む著明な血圧上昇反応が認められる傾向にあり,この介入により高血圧症の発症や進行に対し予防効果があることが示唆された.また,安静時よりも早期に運動時の末梢血管抵抗の低下が起こる可能性が示唆された

中高年者の運動療法を目的としたトレッドミルプロトコールとその臨床応用

小熊, 祐子, 石田, 浩之, 勝川, 史憲, 木下, 訓光, 大西, 祥平 and 山崎, 元

日本臨床スポーツ医学会誌 8 ( 3 ) 252 - 259 2000.07

Joint Work, ISSN 1346-4159

ライフスタイルとその改善が体脂肪と骨量に及ぼす効果について　ホルモン補充療法の骨量に対する効果がプラトーに達した時点における検討

柳本, 茂久, 太田, 博明, 高松, 潔, 牧田, 和也, 野澤, 志朗, 小熊, 祐子, 勝川, 史憲 and 山崎, 元

体力科学 49 ( 2 ) 350 2000.04

ISSN 0039-906X

身体活動量と運動強度の評価　Activtracerを用いて

小熊, 祐子, 大西, 祥平, 山本, 哲史, 木下, 訓光, 石田, 浩之, 勝川, 史憲 and 山崎, 元

体力科学 49 ( 2 ) 348 2000.04

ISSN 0039-906X

【インスリン抵抗性改善薬　チアゾリジン誘導体の薬理と臨床応用の最新動向】　各種病態とインスリン抵抗性　チアゾリジン誘導体の臨床応用の展望　肥満症とインスリン抵抗性

小熊祐子, 片岡邦三

日本臨床 58 ( 2 ) 411 - 415 2000.02

ISSN 0047-1852

肥満症とインスリン抵抗性．

日本臨床 58 ( 2 ) 2000.02

Joint Work

減量目標体重をどこに設定すべきか? 体組成の面からの検討

勝川史憲, 小熊祐子, 山本哲史, 木下訓光, 石田浩之, 福沢素子, 大西祥平, 山崎元 and 林啓介

6 106 2000

中高年者の運動療法を目的としたトレッドミルプロトコールとその臨床応用

小熊祐子, 石田浩之, 勝川史憲, 木下訓光, 大西祥平 and 山崎元

日本臨床スポーツ医学会誌 8 252 - 259 2000

身体活動量と運動強度の評価 Activtracerを用いて

小熊祐子, 大西祥平, 山本哲史, 木下訓光, 勝川史憲, 山崎元 and 石田浩之

49 348 2000

インスリン抵抗性改善薬チアゾリジン誘導体の薬理と臨床応用の最新動向各種病態とインスリン抵抗性チアゾリジン誘導体の臨床応用の展望肥満症とインスリン抵抗性

小熊祐子 and 片岡邦三

58 411 - 415 2000

慢性腰痛症と日常生活との関連についての疫学的調査

八木紫, 大西祥平, 常川尚美, 大林千代美, 山本哲史, 小熊祐子, 木下訓光, 勝川史憲 and 山崎元

49 806 2000

ライフスタイル修正が運動時の血圧に及ぼす効果肥満・糖尿病患者を対象として

味村純, 小熊祐子, 辻岡三南子 and 山崎元

88 1371 - 1375 2000

生活習慣病に対する早期の非薬物治療が血圧に及ぼす効用の縦断的検討を試みた。運動負荷試験を用いて運動負荷時の血圧変化や心拍変化に対する,1年間にわたる運動・食事療法の効果について検討した。対象は肥満・糖尿病男性患者29例(平均46.2±9.7歳)であった。対象はライフスタイル介入後に体重・内臓脂肪の有意な減少と体脂肪率の減少傾向を認め,しかも除脂肪体重の維持と運動耐容時間の延長という介入効果を得た。また軽い運動強度において特に血圧上昇反応を減少させる効果を認めた。今回の介入により高血圧症の発症や進行に対し,予防効果があること,安静時よりも早期に運動時の末梢血管抵抗の低下が起こる可能性が示唆された。

ライフスタイルとその改善が体脂肪と骨量に及ぼす効果についてホルモン補充療法の骨量に対する効果がプラトーに達した時点における検討

柳本茂久, 太田博明, 高松潔, 牧田和也, 野沢志朗, 小熊祐子, 勝川史憲 and 山崎元

49 350 2000

若年アスリート用トレッドミル運動負荷プロトコール当センターにおける試み

山本哲史, 木下訓光, 八木紫, 常川尚美, 大林千代美, 小熊祐子, 勝川史憲, 大西祥平 and 山崎元

49 705 2000

Physiological profile of middle-aged and older climbers who ascended Gasherbrum II an 8035-m Himalayan peak.

Kinoshita N., Yamazaki H., Onishi S., Oguma Y., Katsukawa F., Horii M.

Journal of Gerontology and Biology 55 630 - 633 2000

Research paper (scientific journal), Joint Work

ライフスタイル修正が運動時の血圧に及ぼす効果―肥満・糖尿病患者を対象として―　

診断と治療 88 8 2000

Research paper (scientific journal), Joint Work

A new treadmill exercise protocol for the elderly to make exercise programs and evaluate physical fitness

Oguma, Yuko, Ishida, Hiroyuki, Katsukawa, Fuminori, Ohnishi, Shohei and Yamazaki, Hajime

Japanese Journal of Clinical Sports Medicine 2000

[Obesity, insulin resistance and the implication of thiazolidinediones]. [Review] [23 refs] [Japanese]

Oguma, Y. and Kataoka, K.

Nippon Rinsho Japanese Journal of Clinical Medicine 58 ( 2 ) 411 - 5 2000

The mechanism of insulin resistance in obesity is not fully understood. In muscle cells, the number of insulin receptor, the function of glucose transporter 4 and the activity of tyrosine kinase decrease. The rink of body fat accumulation and insulin resistance in muscle is thought through free fatty acid and tumor necrosis factor alpha secreted in adipose tissue. Thiazolidinediones (TZDs) are useful to reduce insulin resistance especially in obesity. TZDs seem to cause small weight gain, but to reduce visceral fat in 12-24 weeks. In longer period, it hasn't been studied very much. There are some unsolved problems. So now, targets of TZDs are obese diabetes failed in other medicines. When using TZDs, be cautious of excess eating and physical inactivity. [References: 23]

黒田善雄他編集「スポーツ医科学キーワード」．

小熊　祐子

臨床スポーツ医学 16 ( 臨時増刊 ) 1999.12

Joint Work

スポーツ栄養の最近の話題―ACSM・ASCNの合同シンポジウムに参加して―．

臨床スポーツ医学 1999.11

Single Work

非糖尿病肥満者における心拍変動解析と活動量の評価　Active tracer及びMemCalc systemを用いて

小熊, 祐子, 大西, 祥平, 勝川, 史憲, 石田, 浩之, 山崎, 元 and 猿田, 享男

肥満研究 5 ( Suppl. ) 161 1999.10

ISSN 1343-229X

トログリタゾン投与の有無による糖質・脂質代謝指標,体脂肪分布の変化の比較検討

河合, 俊英, 武井, 泉, 小熊, 祐子, 勝川, 史憲, 広瀬, 寛 and 猿田, 享男

肥満研究 5 ( Suppl. ) 189 1999.10

ISSN 1343-229X

耐糖能異常を有する正常体重者の内臓脂肪過剰蓄積の有無による動脈硬化進展への影響

宮本, 和則, 武井, 泉, 小熊, 祐子, 島田, 朗, 増本, 真美, 石田, 浩二, 竹下, 栄子, 渡辺, 清明, 猿田, 享男 and 井上, 修二

肥満研究 5 ( Suppl. ) 136 1999.10

ISSN 1343-229X

ウェスト径と腹部脂肪面積,体組成の関連についての検討　年齢の影響も含めて

勝川, 史憲, 小熊, 祐子, 木下, 訓光, 石田, 浩之, 福澤, 素子, 大西, 祥平 and 山崎, 元

肥満研究 5 ( Suppl. ) 129 1999.10

ISSN 1343-229X

内臓脂肪及び皮下脂肪蓄積各々と代謝異常の関連

勝川, 史憲, 小熊, 祐子, 木下, 訓光, 石田, 浩之, 福澤, 素子, 大西, 祥平 and 山崎, 元

肥満研究 5 ( Suppl. ) 126 1999.10

ISSN 1343-229X

Effects of Troglitazone on fat distribution in the trearment of male type ２ diabetes.

Kawai, T., Takei, I., Oguma, Y., Ohashi, N., Tokui, M., Oguchi, S., Katsukawa, F., Hirose, H., Shimada, A., Watanabe, K. and Saruta, T.

Metabolism 48 ( 9 ) 1102 - 1107 1999.09

Joint Work, ISSN 0026-0495

We investigated the efficacy of additional administration of 400 mg troglitazone (+T), which became available as a treatment for type 2 diabetes following the demonstration of its ability to reduce insulin resistance, in combination with diet (D + T) or sulfonylurea (S + T) therapy. Body fat area as determined by computed tomographic (CT) scanning at the umbilical level, as well as several clinical and biochemical parameters of glycemic control and lipid metabolism, were compared before and after 3 months of additional treatment with troglitazone. The body mass index (BMI) tended to increase in both groups (22.7 +/- 0.6 v 23.2 +/- 0.6 kg/m2 in D + T, nonsignificant [NS]; 22.2 +/- 0.5 v 22.3 +/- 0.5 kg/m2 in S + T, NS), while it tended to decrease in the control group (only diet therapy, 23.6 +/- 0.6 v 23.1 +/- 0.8 kg/m2, NS). Mean blood pressure ([BP] 96 +/- 3 v 89 +/- 4 mm Hg, P < .05) decreased significantly in the D + T group. Changes in the glycemic and lipid profile and leptin did not reach statistical significance. The D + T group showed a significant decline in immunoreactive insulin ([IRI] 12.4 +/- 1.2 v 8.0 +/- 1.0 microU/mL, P < .05), reflecting markedly reduced insulin resistance, as well as a significant increase in plasma insulin-like growth factor-1 ([IGF-1] 175.7 +/- 14.2 v 189.8 +/- 12.6 ng/mL, P < .05). A slight weight gain was associated with a tendency for subcutaneous fat to increase, while visceral fat decreased in both troglitazone-treated groups. The decrease in the visceral to subcutaneous fat ratio (V/S ratio) was statistically significant in the D + T group (1.09 +/- 0.11 v 0.94 +/- 0.09, P < .05), while the V/S ratio in the control group did not change. A notable finding of this study is the difference in the response to troglitazone between subcutaneous and visceral adipose tissue. It is suggested that troglitazone may exert beneficial effects by reducing visceral fat.

エクササイズと食事の最新知識． (Exercise,Nutrition,and Health)

ナップ 1999.07

Joint Work

第46回アメリカスポーツ医学会年次集会に参加して．

1998年慶應義塾大学スポーツ医学研究センター紀要 1999.07

Joint Work

QCTの10年間継続施行例における骨量の減衰と薬剤投与によるその抑制の検討

太田, 博明, 牧田, 和也, 柳本, 茂久, 冬城, 高久, 高松, 潔, 小熊, 祐子, 勝川, 史憲, 山崎, 元 and 野沢, 志朗

日本骨代謝学会雑誌 17 ( 2 ) 147 1999.06

ISSN 0910-0067

生活習慣病予防のための運動・スポーツメディカルチェックのあり方．

臨床スポーツ医学 16 ( 6 ) 653-658 1999.06

Joint Work

【生活習慣病予防のための運動・スポーツ】　メディカルチェックのあり方

小熊, 祐子 and 山崎, 元

臨床スポーツ医学 16 ( 6 ) 653 - 658 1999.06

ISSN 0289-3339

生活習慣病患者の運動療法のためのアンケート調査　通院・継続の要因

小口, 江美子, 白波瀬, 丈一郎, 小熊, 祐子, 石田, 浩之, 浅井, 昌弘 and 山崎, 元

運動療法と物理療法 10 ( 2 ) 162 - 171 1999.04

ISSN 1342-7776

「運動療法教室はライフスタイル改善のきっかけになったと思う」「受診したので,その後安心してトレーニングできる」「定期的に受診しながら運動を継続したい」の得点が高かった.主治医から見てよく運動療法に適応している患者群は「健康感」や「楽しさ」に関する得点が高く,時間的余裕がないにも拘わらず家族や運動仲間に恵まれ,病院との二人三脚を自覚し,上手く運動療法を自分の生活に取り入れていた.以上から,家族や病院を含む患者の周辺において,患者のライフスタイル改善継続のモチベーションを,時間経過と程度に応じて段階的に支え続けられるサポートチームとしての支援体制が重要であることが示唆された

プロインスリン/インスリン(PI/I)比とインスリン抵抗性との関係

宮本, 和則, 武井, 泉, 小熊, 祐子, 増本, 真美, 石田, 浩二, 竹下, 栄子, 渡辺, 清明, 猿田, 享男 and 井上, 修二

糖尿病 42 ( Suppl.1 ) S238 1999.04

ISSN 0021-437X

糖尿病患者における自律神経機能と身体活動度の評価　Activetracer及びMemCalc法を用いて

小熊, 祐子, 大西, 祥平, 勝川, 史憲, 石田, 浩之, 山崎, 元 and 猿田, 享男

糖尿病 42 ( Suppl.1 ) S106 1999.04

ISSN 0021-437X

【糖尿病食事療法を検証する】　糖尿病食事療法に用いる食品交換表の再考

山下, 光雄, 渡辺, 隆子, 片岡, 邦三, 小熊, 祐子, 石田, 浩之, 猿田, 亨男, 木下, 訓光, 勝川, 史憲, 味村, 純, 大西, 祥平 and 山崎, 元

Diabetes Frontier 10 ( 1 ) 43 - 46 1999.02

ISSN 0915-6593

2型糖尿病患者におけるTroglitazoneの糖・脂質代謝,凝固・線溶系に及ぼす影響

丸山, 博, 寺内, 正子, 広瀬, 寛, 島田, 朗, 大橋, 徳巳, 小熊, 祐子, 宮本, 和則, 河合, 俊英 and 猿田, 享男

日本内科学会雑誌 88 ( 臨増 ) 193 1999.02

ISSN 0021-5384

高インスリン血症・耐糖能異常者の体組成と代謝指標ならびにフィットネス　ライフスタイル修正の効用も含めて

小熊, 祐子

慶應医学 76 ( 1 ) 9 - 24 1999.01

ISSN 0368-5179

1)対象は,幅広いBMI層に分布した.若年者でBMIが高い傾向に,高齢者ではHbA1cが高い傾向にあった. 2)横断的検討で,体脂肪とくに内臓脂肪蓄積が多いほどフィットネス・レベルは低い傾向にあった.体脂肪の多い者でグルコースクランプ法でのインスリン抵抗性が強かった.フィットネス・レベルの高い者ではインスリン抵抗性は弱かった. 3)縦断的検討で,介入後1年の時点で,体脂肪量,体脂肪率,内臓脂肪・皮下脂肪蓄積の減少と共に,フィットネス・レベルは上昇し,HbA1c,空腹時血糖,血糖曲線下面積,総コレステロール,中性脂肪,HDLコレステロール,血圧などの代謝指標は改善した

生活習慣病患者の運動療法のためのアンケート調査通院・継続の要因

小口江美子, 白波瀬丈一郎, 小熊祐子, 石田浩之, 浅井昌弘 and 山崎元

10 162 - 171 1999

初診から1年近く継続的に運動療法教室に通う生活習慣病患者39名を対象として運動療法に関するアンケート調査を行い,通院・継続の要因を検討した。回答の中では「運動療法教室はライフスタイル改善のきっかけになったと思う」「受診したので,その後安心してトレーニングできる」「定期的に受診しながら運動を継続したい」の得点が高かった。主治医から見て運動療法によく適応している患者群は「健康感」や「楽しさ」に関する得点が高かった。これらの患者は時間的余裕がないにもかかわらず家族や運動仲間に恵まれ,病院との二人三脚を自覚し,運動療法を上手く自分の生活に取り入れていた。

Clinical associations of polymorphisms in angiotensin-I converting enzyme, angiotensin-II type 1 receptor and aldose reductase genes in Japanese non-insulin-dependent diabetics.

Takei I, Oguma Y, Ohasi N, Funae O, Miyamoto K, Ishii M, Tokui M, Saruta T, Yamauchi A, Nakamoto S

Diabetes Research 34 59 - 72 1999

Research paper (scientific journal), Joint Work

高インスリン血症・耐糖能異常者の体組成と代謝指標ならびにフィットネス-ライフスタイル修正の効用も含めて-　

慶應医学 76 　9-24 1999

Research paper (scientific journal), Single Work

糖尿病食事療法に用いる食品交換表の再考　

Diabetes Frontier 10 43-46 1999

Research paper (scientific journal), Joint Work

生活習慣病患者の運動療法のためのアンケート調査ー通院・継続の要因ー　

運動物理療法 10 161-171 1999

Research paper (scientific journal), Joint Work

第１５回国際Puijoシンポジウムに参加して

臨床スポーツ医学 16 118 1999

Research paper (scientific journal), Single Work

マクロニュートリエントバランス（港区民大学“スポーツと医学の接点”）

三田評論 1010 80-82 1999

Research paper (scientific journal), Single Work

The relationships among physical fitness, adiposity, metabolic parameters and its clustering in Japanese men with mild glucose intolerance and/or hyperinsulinemia

Oguma, Yuko

J Keio Med Society 76 ( 1 ) 9 - 24 1999

糖尿病食事療法を検証する糖尿病食事療法に用いる食品交換表の再考

山下光雄, 片岡邦三, 小熊祐子, 石田浩之, 猿田亨男, 木下訓光, 勝川史憲, 味村純 and 山崎元

10 43 - 46 1999

糖尿病食事療法のための食品交換表を使用した経験から栄養指導上の改善点及び解決策について,以下の項目に分けて解説した。1)食品成分表と食品交換表の変遷,2)栄養指導の方法,3)食品交換の原則-a)栄養成分の優先順位,b)栄養素配分の簡略化,4)糖尿病食品交換表の再考-a)栄養指導での熱量当量について,b)数表示による理解の困難さ,5)糖尿病食品交換表の問題点-a)形の大きさや物差しを用いた栄養価の理解,b)三大栄養素をカロリーで表示。

高インスリン血症・耐糖能異常者の体組成と代謝指標ならびにフィットネスライフスタイル修正の効用も含めて

小熊祐子

76 9 - 24 1999

糖尿病さらには動脈硬化性疾患のハイリスクとして,高インスリン血症ないし耐糖能異常の日本人男性93名を対象とし,運動療法と食事療法をあわせてライフスタイル修正を行い,身体的フィットネス,対組成,代謝指標,インスリン抵抗性との関連につて検討した。その主な結果:動脈硬化危険因子集積は,年齢が高く,内臓脂肪蓄積の多い者で多く,フィットネス・レベルの高い者で少なかった。縦断的検討で,介入後1年の時点で,体脂肪量,体脂肪率,内臓脂肪・皮下脂肪蓄積の減少とともに,フィットネス・レベルは上昇し,Hb1c,空腹時血糖,血糖曲線下面積,総コレステロール,血圧などの代謝指標は改善した。運動療法(身体活動量増加)に加え食事療法(主に脂肪を減らす)の実践ができなかった群では上記の効果は認められなかった。

生活習慣病予防のための運動・スポーツメディカルチェックのあり方

小熊祐子 and 山崎元

16 653 - 658 1999

運動を安全に効果的に行うために,運動開始前にメディカルチェックを施行するが,これは運動する上でリスクとなる心疾患やその危険因子の検出とその評価が中心となる。まず,健康状態のスクリーニングを行い,さらにメディカルチェックを実施する。その内容について次項に従い解説した。1)チェック項目(病歴・生活歴,現症,身体所見,検査項目),2)運動負荷試験の適応,3)運動負荷試験プロトコール。

OLETFラットにおけるhGH,IGF-Iの影響

武井, 泉, 大橋, 徳巳, 小熊, 祐子, 宮本, 和則, 島田, 朗, 渡辺, 清明, 猿田, 享男, 石川, 誠, 古賀, けい子 and 片岡, 邦三

肥満研究 4 ( Suppl. ) 143 1998.11

ISSN 1343-229X

血中Proinsulinと体脂肪分布・代謝指標・血圧との関連　年齢の影響をふくめて

勝川, 史憲, 木下, 訓光, 大西, 祥平, 山崎, 元, 小口, 修司, 山田, 悟, 小熊, 祐子, 石田, 浩之, 福澤, 素子 and 片岡, 邦三

肥満研究 4 ( Suppl. ) 141 1998.11

ISSN 1343-229X

肥満治療　運動・食事療法　正常〜過体重の耐糖能異常男性に対する運動・食事療法　体組成・糖脂質代謝・フィットネスの関連

小熊, 祐子, 勝川, 史憲, 山田, 悟, 河合, 俊英, 石田, 浩之, 武井, 泉, 山崎, 元 and 猿田, 享男

肥満研究 4 ( Suppl. ) 99 1998.11

ISSN 1343-229X

BMI変動が動脈硬化危険因子に与える影響　ドック受診者における5年間の長軸的検討

石田, 浩之, 勝川, 史憲, 小熊, 祐子, 大西, 祥平, 川村, 昌嗣, 山崎, 元 and 猿田, 享男

肥満研究 4 ( Suppl. ) 121 1998.11

ISSN 1343-229X

更年期外来受診者における体組成とフィットネス・レベルに関する検討

冬城, 高久, 太田, 博明, 柳本, 茂久, 牧田, 和也, 高松, 潔, 野澤, 志朗, 小熊, 祐子, 勝川, 史憲 and 山崎, 元

日本更年期医学会雑誌 6 ( Suppl. ) 122 1998.11

ISSN 0919-5033

中・高年男性の体脂肪分布・糖脂質代謝　年代別検討

山田, 悟, 小熊, 祐子, 武井, 泉, 勝川, 史憲, 河合, 俊英, 宮本, 和則, 石田, 浩之, 山崎, 元 and 猿田, 享男

肥満研究 4 ( Suppl. ) 112 1998.11

ISSN 1343-229X

プロインスリン/インスリン(PI/I)とインスリン抵抗性との関係

宮本, 和則, 武井, 泉, 小熊, 祐子, 増本, 真美, 石田, 浩二, 竹下, 栄子, 渡辺, 清明, 猿田, 享男 and 井上, 修二

肥満研究 4 ( Suppl. ) 140 1998.11

ISSN 1343-229X

生活習慣病患者の運動療法の為のアンケート調査　通院・継続の要因

小口, 江美子, 小熊, 祐子, 白波瀬, 丈一郎, 石田, 浩之 and 山崎, 元

運動療法研究会抄録集 ( 23回 ) 14 1998.05

ISSN 1347-9091

軽症耐糖能異常男性の心肺系fitnessと動脈硬化危険因子集積・体脂肪分布との関連

小熊, 祐子他

糖尿病 41 ( Suppl.1 ) 343 1998.04

ISSN 0021-437X

Thrifty GenotypeとThrifty Phenotype

小熊, 祐子, 勝川, 史憲 and 武井, 泉

内分泌・糖尿病科 6 ( 4 ) 358 - 366 1998.04

ISSN 1341-3724

若年過体重男性において,身体的フィットネスは内臓脂肪蓄積,代謝指標と関連するか?

勝川史憲, 木下訓光, 大西祥平, 山崎元, 小熊祐子 and 石田浩之

15 641 - 646 1998

若年過体重男性130名(18-24歳)を対象に,身体的フィットネスレベルと代謝指標,体組成の関連を検討した。その結果,フィットネスの指標は,全身的な体脂肪蓄積の低値と関連し,内臓脂肪蓄積についても同様の傾向を示したが,関連は弱かった。一方,フィットネスの指標は血中インシュリンの低値と関連したが,脂質代謝指標とは関連しなかった。以上の所見より,肥満者で虚血性心疾患リスクの低下を図る際には,フィットネス向上を目指した運動を行うよりも,エネルギー消費の増大から肥満自体の改善を目指した方策を講じる必要があることが示唆された。

Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure : A preliminary report.

Takei I, Takayama S, Yamauchi A, Nakamoto S, Kitamura Y, Katsukawa H, Yamazaki H, Saruta T, Inoue S

Europian Journal of Clinical Nutrition 52 153 - 154 1998

Research paper (scientific journal), Joint Work

若年過体重男性において, 身体的フィットネスは内臓脂肪蓄積、代謝指標と関連するか？

臨床スポーツ医学 15 211-216 1998

Research paper (scientific journal), Joint Work

Q&A糖尿病なんでも相談室

べんちのーと 41 ( 　11-4 ) 23 1998

Research paper (scientific journal), Single Work

【内分泌・代謝疾患state of arts】　主要疾患　現況・病態・診断・治療　インスリン抵抗性症候群(シンドロームX)

武井, 泉 and 小熊, 祐子

医学のあゆみ別冊 ( 内分泌・代謝疾患 ) 480 - 481 1997.10

ISSN 0039-2359

正常〜過体重の耐糖能異常者に対する運動療法の成績　糖・脂質代謝,体脂肪分布,レプチン,IGF-1の変化

小熊, 祐子 and 他

肥満研究 3 ( Suppl. ) 111 1997.10

ISSN 1343-229X

軽症耐糖能異常者を対象とした運動療法の成績　糖質・脂質代謝及び体脂肪分布への効果

小熊, 祐子 and 他

糖尿病 40 ( Suppl.1 ) 436 1997.04

ISSN 0021-437X

内分泌・代謝疾患 state of arts 主要疾患現況・病態・診断・治療インスリン抵抗性症候群シンドロームX

武井泉 and 小熊祐子

480 - 481 1997

Cilostazol, a phosphodiesterase inhibitor for the treatment of diabetic neuropathy.

Takei I, Nakamoto S, Ishii M, Yamauchi A, Tokui M, Ohhashi N, Kitamura Y, Miyamoto K, Funai O, Saruta T

Diabetes Research 32 19 - 25 1997

Research paper (scientific journal), Joint Work

身体活動、三大栄養素バランスと体重コントロール

臨床スポーツ医学 14 476-483 1997

Research paper (scientific journal), Single Work

若年肥満者の体組成とエネルギー消費の検討―運動療法と脂肪制限食の減量効果を含めて

臨床スポーツ医学 14 91-96 1997

Research paper (scientific journal), Joint Work

長期生存を認めている副腎癌の１例

ホルモンと臨床 45 171-175 1997

Research paper (scientific journal), Joint Work

インスリン低反応のIGTおよび糖尿病に対するVogliboseの効果―短期投与(3ヶ月)の効果についてー　

薬理と治療 24 213-217 1997

Research paper (scientific journal), Joint Work

肥満の新しい食事療法（三大栄養素バランス）

毎日ライフ 12 27-30 1997

Research paper (scientific journal), Single Work

内分泌興味ある症例長期生存を認めている副腎癌の1例

家田真樹, 丸山博, 小熊祐子, 猿田享男, 橘正昭, 村井勝, 向井万起男, 本間桂子 and 相羽元彦

45 171 - 175 1997

症例は50歳女性で,30歳時より男性化徴候が出現し,32歳時に副腎皮質癌の診断で左副腎全摘術を行い,その後右大腿骨,右副腎,大動脈周囲リンパ節および肝への転移に対して切除術を行った。その後経過観察中に腹部CTから大動脈周囲のリンパ節の腫大,胸部X線上結節性陰影の出現,尿中ステロイドの上昇傾向を認めた。検査所見からホルモン産生性副腎癌の後腹膜リンパ節転移,肺転移と診断し,同切除術を行った。術後経過は良好であり,診断後18年経過の長期生存例である。

ホルモン補充療法の骨代謝上のresponseに及ぼすライフスタイルの影響栄養摂取量と運動能を中心に

冬城高久, 太田博明, 高松潔, 野沢志朗, 辻秀一, 勝川史憲, 石田浩之, 小熊祐子 and 山下光雄

15 269 1997

肥満型NIDDMにおける内臓脂肪蓄積とIGF-1(insulin like growth factor 1)との関係

小熊, 祐子, 武井, 泉, 山内, 晃 and 他

肥満研究 2 ( 2 ) 107 - 109 1996.12

ISSN 1343-229X

肥満型NIDDMにおける内臓脂肪蓄積とIGF-1(insulin like growth factor 1)との関係

肥満研究 2 37-39 1996

Research paper (scientific journal), Joint Work

Depression of dehydroepiandrosterone in Japanese diabetic men ?comparison between non-insulin dependent diabetes and impaired glucose tolerance.

Yamauchi A, Takei I, Kasuga A, Kitamura Y, Ohashi N, Nakano S, Takayama S, Nakamoto S, Katsukawa F, Saruta T

Europian Journal of Clinical Nutrition 35 101 - 104 1996

Research paper (scientific journal), Joint Work

Hyperglycemia decreases dehydroepiandrosterone in Japanese male with impaired glucose tolerant and low insulin response.

Yamauchi A, Takei I, Nakamoto S, Ohashi N, Kitamura Y, Tokui M, Nakano S, Tkayama S, Kasuga A, Katsukawa F, Saruta T

Endocrine Journal 43 285 - 290 1996

Research paper (scientific journal), Joint Work

Antibodies to the 37,000-Mr Tryptic fragment of islet antigen were detected in Japanese insulin ?dependent diabetes mellitus patients.

Ozawa Y, Kasuga A, Maruyama T, Kitamura Y, Amemiya S, Ishihara T, Suzuki R, Saruta T

Endocrine Journal 43 615 - 620 1996

Research paper (scientific journal), Joint Work

経皮経肝血栓除去術を施行した上腸間膜静脈血栓症の１例

日本消化器病学会誌 92 158-163 1995

Research paper (scientific journal), Joint Work

Fibrinogen, Factor VIII and von Willebrand Factor Antigen in Japanese NIDDM patients.

Takei I, Nakamoto S, Yamauchi A, Ohashi N, Kitamura Y, Tokui M, Nakano S, Takayama S, Kasuga A, Saruta T

Diabetes Research 29 83 - 91 1995

Research paper (scientific journal), Joint Work

シェーグレン症候群と血小板増多症を合併した非硬変性門脈圧亢進症の１例

日本消化器病学会誌 92 95-100 1995

Research paper (scientific journal), Joint Work

運動量の多い人の食事

べんちのーと 37 ( 　10-4 ) 14-15 1994

Research paper (scientific journal), Joint Work

Acquired idiopathic pure red cell aplasia in a hemodialyzed patient with inactive systemic lupus erythematosus.

Okada H, Suzuki H, Uchida H, Kanno Y, Kitamura Y, Hisamatsu T, Deguchi N, Hayashi D, Saruta T

Internal Medicine 33 492 - 495 1994

Research paper (scientific journal), Joint Work

血漿交換療法が奏効したEMO症候群の１例

日本内科学会会誌 83 308-310 1994

Research paper (scientific journal), Joint Work

重症肝障害、播種性血管内凝固（DIC）を合併した成人発症Still病の１症例

日本内科学会会誌 83 2151-2153 1994

Research paper (scientific journal), Joint Work

自然壊死部がCT上脂肪濃度を呈した肝細胞癌

Therapeutic Research 15 254-258 1994

Research paper (scientific journal), Joint Work

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