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Papers - Oguma, Yuko

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特集内臓脂肪・皮下脂肪と運動食事療法による内臓脂肪,皮下脂肪の変化

小熊祐子

21 747 - 752 2004

食事療法による内臓脂肪,皮下脂肪の変化に関する代表的な近年の研究結果について,以下の項目別に紹介した。食事療法による内臓脂肪の変化に関する文献のまとめを表示した。1)Rossらの研究(2000),2)Rossらの研究(1996),3)Janssenの研究(2002),4)Nicklasらの研究(2003),5)Goodpasterの研究(1999),6)まとめ-減量法の如何にかかわらず,減量時の内臓脂肪量の減少率は,体重,総脂肪量,皮下脂肪量の減少率より大きかった,内臓脂肪を特異的に減少させる好ましい介入方法についてははっきりしなかった。

肥満者におけるレジスチンと運動耐容能の検討

東宏一郎, 佐々木誠一, 勝川史憲, 小熊祐子, 成田和穂, 木下訓光, 石田浩之, 大西祥平 and 小口修司

12 260 - 265 2004

男性13名,女性25名の非糖尿病肥満者を対象に,運動耐容能と糖負荷試験での血糖,インスリン,体組成,体脂肪分布との関連について検討し,レジスチン血中濃度を測定した。運動耐容能の指標としての負荷試験中の運動継続時間体組成と相関したが,インスリン抵抗性との相関は明らかではなく,レジスチン血中濃度とも相関しなかった。レジスチン血中濃度はインスリン抵抗性の指標,体組成とも相関がなかった。

Lack of association between tea and cardiovascular disease in college alumni

Sesso, H. D., Paffenbarger, R. S., Jr., Oguma, Y. and Lee, I. M.

Int J Epidemiol 32 ( 4 ) 527 - 33 2003.08

ISSN 0300-5771

BACKGROUND: Epidemiological studies suggest that tea intake, a major dietary source of flavonoids, may be associated with a decreased risk of cardiovascular disease (CVD). METHODS: We prospectively followed 17 228 subjects (mean age, 59.5 years) initially free of CVD and cancer from the College Alumni Health Study. Participants provided baseline self-reports of tea consumption (cups/day) and coronary risk factors. During a median follow-up of 15 years, there were 3372, 2615, and 757 cases of CVD, coronary heart disease (CHD), and stroke, respectively, ascertained from either self-reports or death certificates. RESULTS: Overall, the median level of tea consumption was 1 cup/day. Compared with participants consuming no tea, the multivariate relative risks (RR) of CVD for those drinking <1, 1, 2, 3, and >/=4 cups/day were 0.99, 0.96, 0.95, 0.91, and 0.95, respectively (P, trend = 0.19). The multivariate RR were 0.97, 0.98, 0.93, 0.85, and 0.98 for CHD (P, trend = 0.25), and 1.05, 0.89, 1.00, 1.09, and 0.83 for stroke (P, trend = 0.53). There was no evidence of effect modification. Changes in tea intake were assessed in a subgroup of 7730 men, with those continuing to drink tea having a non-significant 33% reduction in the risk of stroke. CONCLUSIONS: Tea intake, likely consumed as black tea, was not strongly associated with a reduced risk of CVD in this population of US college alumni.

高齢女性における身体活動量と総死亡率との関連　大学卒業生前向きコホート研究

小熊, 祐子, Sesso, Howard D., Paffenbarger, Jr Ralph S., 山崎, 元 and Lee, I-Min

日本更年期医学会雑誌 11 ( 1 ) 34 - 41 2003.04

ISSN 0919-5033

1980年に心血管系疾患・癌(メラノーマ以外の皮膚癌を除く)に罹患していなかったペンシルバニア大学卒業生女性1123例を1995年まで追跡し,高齢女性における身体活動量と総死亡率との関連を検討した.身体活動量は総死亡率と負の関連が認められた.特に,1日に12ブロック(1マイル相当)以上歩行していた女性は追跡期間中死亡する危険度が4ブロック未満の女性に比し31%低かった.高齢女性において,中等度の強度の身体活動でも死亡率低下につながることが示唆された

Unusual left ventricular dilatation without functional or biochemical impairment in normotensive extremely overweight Japanese professional sumo wrestlers

Kinoshita, N., Onishi, S., Yamamoto, S., Yamada, K., Oguma, Y., Katsukawa, F. and Yamazaki, H.

Am J Cardiol 91 ( 6 ) 699 - 703 2003.03

ISSN 0002-9149

To explore the physiologic limit of left ventricular (LV) enlargement, we performed echocardiography and air displacement plethysmography to respectively assess LV dimension and function and the body composition of Japanese professional sumo wrestlers. After excluding subjects with cardiovascular disease, hypertension, plasma brain natriuretic peptide (BNP) > or =17.9 pg/ml, diabetes mellitus, or asthma, 331 subjects (mean +/- SD age, 21.6 +/- 3.7 years; height 179.2 +/- 5.3 cm; weight 1,17.9 +/- 21.5 kg; percent fat, 29.6 +/- 6.6%) were analyzed. LV end-diastolic dimension averaged 58.4 +/- 3.7 mm and was within the generally regarded normal limit (< or =54 mm) in 14.5% of subjects, but was > or =60 mm in 41.1% of subjects. LV septal and posterior wall thicknesses were 10.3 +/- 0.9 and 10.2 +/- 0.9 mm, respectively. Peak E- and A-wave velocities, E/A ratio, LV fractional shortening, and BNP were 96 +/- 16 and 51 +/- 13 cm/s, 2.0 +/- 0.7, 33.5 +/- 4.5%, and 3.1 +/- 3.7 pg/ml, respectively. LV end-diastolic dimension was not correlated with these indexes of LV function or with plasma BNP levels, but was significantly correlated with height, weight, body surface area, fat-free mass, and fat mass. These results show that among very large, highly trained, professional athletes, LV end-diastolic dimension frequently exceeds the traditionally accepted upper limit of normal for the general population. This increase in LV end-diastolic dimension may thus represent an extreme example of the physiologic adaptation of the athlete's heart.

Physical activity, body weight, and pancreatic cancer mortality

Lee, I. M., Sesso, H. D., Oguma, Y. and Paffenbarger, R. S., Jr.

Br J Cancer 88 ( 5 ) 679 - 83 2003.03

ISSN 0007-0920

Relative intensity of physical activity and risk of coronary heart disease

Lee, I. M., Sesso, H. D., Oguma, Y. and Paffenbarger, R. S., Jr.

Circulation 107 ( 8 ) 1110 - 6 2003.03

ISSN 1524-4539

BACKGROUND: Current recommendations prescribe at least moderate-intensity physical activity, requiring >or=3 METs (metabolic equivalents) for >or=30 minutes almost daily, generating approximately 1000 kcal/wk. Defining intensity using an absolute scale in METs may be limited because it neglects variations in physical fitness: an activity requiring a particular MET value commands greater physical effort among less fit than more fit persons. It is unknown whether moderate-intensity exercise, relative to an individual's capacity, is associated with reduced coronary heart disease (CHD) rates. METHODS AND RESULTS: We followed 7337 men (mean age, 66 years) from 1988 to 1995. At baseline, men reported their actual activities and, using the Borg Scale, the perceived level of exertion when exercising (relative intensity). During follow-up, 551 men developed CHD. After multivariate adjustment, the relative risks of CHD among men who perceived their exercise exertion as "moderate," "somewhat strong," and "strong" or more intense were 0.86 (95% confidence interval, 0.66 to 1.13), 0.69 (0.51 to 0.94), and 0.72 (0.52 to 1.00), respectively (P(trend)=0.02), compared with "weak" or less intense. This inverse association extended to men not fulfilling current recommendations, ie, expending <1000 kcal/wk in physical activity or not engaging in activities of >or=3 METs (P(trend)=0.03 and 0.007, respectively). CONCLUSIONS: There is an inverse association between relative intensity of physical activity (an individual's perceived level of exertion) and risk of CHD, even among men not satisfying current activity recommendations. Recommendations for "moderate"-intensity physical activity may need to consider individual fitness levels instead of globally prescribing activities of >or=3 METs.

高齢女性における身体活動量と総死亡率との関連―大学卒業生前向きコホート研究―　

日本更年期医学会雑誌 11 34-41 2003

Research paper (scientific journal), Joint Work

Relative intensity of physical activity and risk of coronary heart disease.

Lee IM, Sesso HD, Oguma Y, Paffenbarger RSJr

Circulation 107 1110-1116 2003

Research paper (scientific journal), Joint Work

Physical activity, body weight, and pancreatic cancer mortality.

Lee IM, Sesso HD, Oguma Y, Paffenbarger RSJr

British Journal of Cancer 88 679-683 2003

Research paper (scientific journal), Joint Work

Lack of association between tea and cardiovascular disease in college alumni.

Sesso HD, Paffenbarger RSJr, Oguma Y, Lee IM

International Journal of Epidemiology 32 527-533 2003

Research paper (scientific journal), Joint Work

Unusual left ventricular dilatation without functional or biochemical impairment in normotensive extremely overweight Japanese professional Sumo wrestlers.

Kinoshita N, Onishi S, Yamamoto S, Yamada K, Oguma Y, Katsukawa F, Yamazaki H

American Journal of Cardiology 91 699-703 2003

Research paper (scientific journal), Joint Work

【生活習慣病の予防と治療　運動・食事・薬物療法と効果的なコンビネーションの実際】　癌　身体活動と癌

小熊, 祐子

臨床スポーツ医学 19 ( 臨増 ) 275 - 280 2002.10

ISSN 0289-3339

運動療法の運動負荷時心筋酸素消費量抑制効果について　肥満・耐糖能異常者を対象として

成田, 和穂, 小熊, 祐子, 辻岡, 三南子, 石田, 浩之, 木下, 訓光, 勝川, 史憲, 大西, 祥平 and 山崎, 元

日本臨床スポーツ医学会誌 10 ( 4 ) S121 2002.09

ISSN 1346-4159

減量幅別にみた体組成,インスリン感受性,アディポサイトカインの変化

勝川史憲, 東宏一郎, 小口修司, 成田和穂, 小熊祐子, 木下訓光, 石田浩之, 福澤素子, 大西祥平 and 山崎元

肥満研究 8 ( Suppl. ) 136 2002.09

ISSN 1343-229X

Physical activity and all cause mortality in women: a review of the evidence

Oguma, Y., Sesso, H. D., Paffenbarger, R. S., Jr. and Lee, I. M.

British Journal of Sports Medicine 36 ( 3 ) 162 - １72 2002.06

Research paper (scientific journal), Joint Work, ISSN 0306-3674

Light wavelength dependency of mating activity in the Drosophila melanogaster species subgroup

Sakai, T., Isono, K., Tomaru, M., Fukatami, A. and Oguma, Y.

Genes Genet Syst 77 ( 3 ) 187 - １95 2002.06

ISSN 1341-7568

The action spectra of mating activity among the six species of the Drosophila melanogaster species subgroup were compared to understand how light wavelength affects mating activity. The species fell into three groups with respect to the action spectrum of mating activity. We chose one representative species from each of the three types for detailed study: D. melanogaster, D. sechellia and D. yakuba. The mating activities were investigated under three different light intensities of three monochromatic lights stimulus. Each species showed a unique spectral and intensity response. To know the evolutionary meaning of the light wavelength dependency of mating activity, we superimposed the type of action spectrum of mating activity in these six species on a cladogram. Mating inhibition under UV was conserved in evolution among these species. Furthermore we clarified that D. melanogaster showed low mating activity under UV because males courted less under UV.

Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes.

Hirose H, Kawai T, Yamamoto Y, Taniyama M, Tomita M, Matsubara K, Okazaki Y, Ishii T, Oguma Y, Takei I, Saruta T

Metabolism: Clinical & Experimental 51 ( 3 ) 314 - 317 2002

Research paper (scientific journal), Joint Work

The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 +/- 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a stable dose of sulfonylurea (n = 3), were studied at baseline and after 3 months of pioglitazone treatment (30 mg/d). Body mass index (BMI), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), serum insulin, adiponectin, and lipid profile were measured. Also, visceral adipose tissue area (VAT) and subcutaneous adipose tissue area (SAT) at the umbilical level were determined by computed tomographic (CT) scanning. Mean blood pressure (109 +/- 14 to 101 +/- 10 mm Hg), FPG (8.6 +/- 1.4 to 7.0 +/- 1.0 mmol/L), serum insulin (54 +/- 11 to 30 +/- 8 pmol/L, P <.01 for all), and HbA1c (6.7 +/- 0.8 to 6.1% +/- 0.6%, P =.013) decreased significantly during 3 months of pioglitazone treatment. BMI (26.4 +/- 3.2 to 27.0 +/- 3.5 kg/m2), low-density lipoprotein (LDL) cholesterol (124 +/- 24 to 138 +/- 24 mg/dL) and SAT (155 +/- 69 to 179 +/- 81cm2, P <.05 for all) increased, while triglycerides and high-density lipoprotein (HDL) cholesterol did not change significantly after 3 months of pioglitazone treatment. Serum adiponectin level increased in all patients (4.8 +/- 1.7 to 14.4 +/- 2.1 microg/mL, P =.005). VAT tended to increase (165 +/- 38 to 180 +/- 46 cm2) and VAT/SAT ratio tended to decrease (1.2 +/- 0.3 to 1.1 +/- 0.3), but these differences did not reach statistical significance. These results suggest that pioglitazone exerts good glycemic and blood pressure control despite increased BMI and SAT in Japanese male patients with type 2 diabetes. It is also suggested that pioglitazone may have an antiatherosclerotic effect by increasing serum adiponectin level. Copyright 2002 by W.B. Saunders Company

身体活動量と癌

臨床スポーツ医学 19 275-280 2002

Research paper (scientific journal), Single Work

ボストン留学生活

臨床スポーツ医学 19 583-586 2002

Research paper (scientific journal), Single Work

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