研究者詳細 - 小熊　祐子

論文 - 小熊　祐子

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Relationships of Muscle Echo Intensity with Walking Ability and Physical Activity in the Very Old Population

Osawa, Y., Arai, Y., Oguma, Y., Hirata, T., Abe, Y., Azuma, K., Takayama, M. and Hirose, N.

Journal of Aging and Physical Activity （HUMAN KINETICS PUBL INC） 25 （ 2 ） 189 - 195 2017年04月

ISSN 1063-8652

This study investigated the relationships between muscle echo intensity (EI), physical activity (PA), and functional mobility in 108 Japanese (88-92 years). We measured EI and muscle thickness (MT) at the midpoint of the anterior superior iliac spine and patella using B-mode ultrasound. Light and moderate-to-vigorous PA (LPA and MVPA) were assessed with a triaxial accelerometer. The timed up and go (TUG) test was used to measure for functional mobility. EI, but not MT, was significantly associated with both TUG scores (beta = 0.17, p =.047) and MVPA (beta = -0.31, p =.01) when adjusted by potential confounders. However, association between EI and TUG disappeared after adjusted for MVPA. Meanwhile, MVPA was significantly associated with TUG scores independent of EI (beta = -0.35, p <.001). Although EI of anterior thigh muscles might be a weaker predictor of functional morbidity than MVPA, it is a noninvasive and practical approach for assessing muscle quality in the very old.

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Effects of stretching exercise with a stretching-support cushion on flexibility in over middle-aged women

Osawa, Y. and Oguma, Y.

Gazzetta Medica Italiana Archivio Per Le Scienze Mediche （Edizioni Minerva Medica） 176 （ 4 ） 180 - 187 2017年04月

ISSN 0393-3660

BACKGROUND: Recently, stretching-support cushions (SC) have become available for use during stretching exercises in the seated position. However, the effects of a SC consisting of a 20-deg posterior support cushion on flexibility-related outcomes when combined with stretching exercises are not well understood. Here, a randomized controlled trial involving 32 healthy over-middle aged women (56.9 +/- 7.4 years old) was performed to investigate the additional effects of stretching program with SC on the flexibility compared with the identical program without SC. METHODS: The participants were randomly assigned to stretching exercises with SC (EX-SC, N.= 16) or the identical stretching exercises without SC (EX, N.= 16). We investigated the additional effects of using SC on flexibility by measuring the degree of hip abduction, pelvic tilt, and maximum forward reaching distance, sit and reach test, and passive torque of right hamstrings during passive knee extension before and after the single session of program. RESULTLTS: After performing the stretching exercises with (EX-SC group) and without (EX group) the SC, significantly change in pelvic tilt in the seated straddle split position was observed in the EX-SC group (21.0 +/- 28.9 to 33.1 +/- 24.0 deg) compared with the EX group (22.1 +/- 20.8 to 26.9 +/- 22.8 deg; P<0.05). For all other flexibility-related parameters, only the time effects were significant (P<0.05). CONCLUSIONS: Taken together, the present results suggest that use of a SC is beneficial for performing stretching exercises when seated to avoid a `rounded-back position'.

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Decrease in regional body fat after long-term high-intensity interval training

Koichiro Azuma, Yusuke Osawa, Shogo Tabata, Fuminori Katsukawa, Hiroyuki Ishida, Yuko Oguma, Toshihide Kawai, Hiroshi Itoh, Shigeo Okuda, Shuji Oguchi, Atsumi Ohta, Haruhito Kikuchi, Mitsuru Murata, Hideo Matsumoto

J Phys Fitness Sports Med 6 （ 2 ） 103 - 110 2017年02月

査読有り

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Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

Fujii, C., Kawai, T., Azuma, K., Oguma, Y., Katsukawa, F., Hirose, H., Tanaka, K., Meguro, S., Matsumoto, H. and Itoh, H.

J Diabetes Res （HINDAWI LTD） 2017 1567467 2017年

ISSN 2314-6745

Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r = -0.411, p < 0.0001), fasting glucose (r = -0.330, p < 0.0001), HbA1c (r = -0.231, p = 0.0146), and systolic blood pressure (r = -0.224, p = 0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r = -0.416, p < 0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. Conclusion. We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.

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Relationship between Social Capital and Cognitive Functions among Community-Based Elderly

Takechi, Sayuri, Yoshimura, Kimio, Oguma, Yuko, Saito, Yoshinobu, Mimura, Masaru

Advances in Alzheimer's Disease 06 （ 02 ） 45 - 51 2017年

ISSN 2169-2459

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運動開始のメディカルチェックについて考える―地域での身体活動促進を念頭に

小熊祐子

慶應義塾大学スポーツ医学研究センター紀要2016 19 - 23 2017年

ハイリスクアプローチとポピュレーションアプローチ，そしてこれから

小熊祐子

日本健康教育学会誌（日本健康教育学会） 25 （ 1 ） 1 - 2 2017年

地域在住85歳以上高齢者における身体活動量の促進・阻害因子　TOOTH study

大澤, 祐介, 新井, 康通, 小熊, 祐子, 高山, 美智代, 平田, 匠, 阿部, 由紀子 and 広瀬, 信義

日本老年医学会雑誌 53 （ 4 ） 469 - 470 2016年10月

ISSN 0300-9173

身体活動量増加のためのコミュニティ・ワイド・キャンペーン　クラスター・非ランダム化試験(「ふじさわプラス・テン」プロジェクト)　研究プロトコル

齋藤, 義信, 小熊, 祐子, 田中, あゆみ, 鎌田, 真光, 井上, 茂, 稲次, 潤子 and 小堀, 悦孝

運動疫学研究: Research in Exercise Epidemiology （日本運動疫学会） 18 （ 2 ） 88 - 98 2016年09月

ISSN 1347-5827

背景:身体活動が健康増進に有益なことは明らかになっているが,非活動的な者は多い。そのため地域(ポピュレーション)レベルの身体活動促進に関する知見の蓄積は重要である。近年,コミュニティ・ワイド・キャンペーン(Community-Wide Campaign;CWC)のような複合的なポピュレーション介入が推奨されているが,エビデンスは十分でない。厚生労働省では,健康づくりのための身体活動指針(アクティブガイド)を発表し,身体活動促進の普及啓発を行っている。今後,地域でどのようにアクティブガイドを活用できるかを検討し,知見を蓄積していくことが重要である。目的:本研究はアクティブガイドを活用したCWCが,ポピュレーションレベルで住民の身体活動量増加につながるかを明らかにすることを目的とした。方法:研究デザインは神奈川県藤沢市の全13地区を非ランダムに介入4地区,対照9地区に割り付けるクラスター・非ランダム化試験である。介入期間は2年間(2013年7月〜2015年6月)とし,対照地区は従来の保健施策を行った。介入は60歳以上の高齢者を主ターゲットとし,(1)情報提供,(2)教育機会,(3)住民間のサポート・コミュニティ形成促進,の要素から構成した。主要評価項目は質問紙で求めた身体活動時間であり,介入前後に藤沢市が20歳以上の住民を無作為抽出して行う質問紙調査の結果を用いて比較する。副次評価項目はアクティブガイドの認知・知識のある者の割合の変化,身体活動の意図がある者の割合の変化等である。介入全体の評価は,RE-AIMモデルを適用する。(著者抄録)

成人非ホジキンリンパ腫サバイバーにおける身体活動と生活の質との関連性

荒武, 喜子, 小松, 浩子, 小熊, 祐子, 石澤, 丈, 森, 毅彦 and 岡本, 真一郎

理学療法科学（理学療法科学学会） 31 （ 4 ） 551 - 558 2016年08月

ISSN 1341-1667

[目的]日本の中悪性度成人非ホジキンリンパ腫(NHL)サバイバーの身体活動量(PA)と健康関連QOL(HRQOL)との関連性を明らかにすることを目的とした。[対象と方法]都内1大学病院通院中のNHL患者(診断後6ヵ月-8年の者)100名(年齢中央値65.0歳)とした。自己記入式質問紙法により得られるPAとHRQOLの関連を重回帰分析にて解析した。[結果]PAは多いほど身体面のHRQOLも有意に高くなるが、精神面のHRQOLに対する寄与は示されなかった。[結語]身体活動の取組みのHRQOL促進に対する有用性が示唆される。(著者抄録)

血中脂肪酸分画と体組成、経口糖負荷試験(OGTT)時の糖代謝指標との関連

河合, 俊英, 東, 宏一郎, 藤井, 千華子, 小熊, 祐子, 松本, 秀男 and 伊藤, 裕

日本内分泌学会雑誌 92 （ 1 ） 245 2016年04月

ISSN 0029-0661

質問紙で評価した身体活動ガイドライン達成者の活動レベル

中田由夫, 井上茂, 大河原一憲, 岡浩一朗, 小熊祐子, 高田和子, 田中茂穂, 田中千晶

体力科学（(一社)日本体力医学会） 65 （ 1 ） 156 - 156 2016年02月

ISSN 0039-906X

プロジェクト研究の概要とGPAQ日本語版の作成

井上茂, 中田由夫, 大河原一憲, 岡浩一朗, 小熊祐子, 高田和子, 田中茂穂, 田中千晶

体力科学（(一社)日本体力医学会） 65 （ 1 ） 155 - 155 2016年02月

ISSN 0039-906X

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

Fukai, K., Harada, S., Iida, M., Kurihara, A., Takeuchi, A., Kuwabara, K., Sugiyama, D., Okamura, T., Akiyama, M., Nishiwaki, Y., Oguma, Y., Suzuki, A., Suzuki, C., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M. and Takebayashi, T.

PLoS One （PUBLIC LIBRARY SCIENCE） 11 （ 10 ） e0164877 2016年

ISSN 1932-6203

OBJECTIVE: Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabolites using a targeted metabolomics approach in a population-based study. METHODS: A total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the baseline survey of a cohort study. Information on daily total physical activity, classified into four levels by quartile of metabolic equivalent scores, and sedentary behavior, defined as hours of sitting per day, was collected through a self-administered questionnaire. Plasma metabolite concentrations were quantified by capillary electrophoresis mass spectrometry method. We performed linear regression analysis models with multivariable adjustment and corrected p-values for multiple testing in the original population (n = 808). The robustness of the results was confirmed by replication analysis in a separate population (n = 385) created by random allocation. RESULTS: Higher levels of total physical activity were associated with various metabolite concentrations, including lower concentrations of amino acids and their derivatives, and higher concentrations of pipecolate (FDR p <0.05 in original population). The findings persisted after adjustment for age, body mass index, smoking, alcohol intake, and energy intake. Isoleucine, leucine, valine, 4-methyl-2-oxoisopentanoate, 2-oxoisopentanoate, alanine, and proline concentrations were lower with a shorter sitting time. CONCLUSIONS: Physical activity is related to various plasma metabolites, including known biomarkers for future insulin resistance or type 2 diabetes. These metabolites might potentially play a key role in the protective effects of higher physical activity and/or less sedentary behavior on non-communicable diseases.

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Evaluation of a Community-based Health Promotion Program with Online Off-line Combination: The Effect of an Online Diet Record System on Self-rated Achievement

Miyagawa, Shoko, Oguma, Yuko and Ohgi, Yuji

Procedia Computer Science （ELSEVIER SCIENCE BV） 100 768 - 775 2016年

ISSN 18770509

The aim of this study is to clarify the effect of e-health community health promotion program, which consists of both online diet record system and off-line health activities. 49 participants are surveyed concerning self-rated sense of understanding and sense of control about calorie intake, nutrition balance, and physical activity along with basic information, internet usage and lifestyle habit are surveyed during 2009-2011. Self-rated sense of achievement regarding dietary understanding and dietary sense of control significantly increased in a group that utilized the online diet record system. Further analysis shows that the usage of the diet record system affects the self-rated sense of achievement while neither age, sex, answers of the preliminary questionnaire nor session participation had any effect. (C) 2016 The Authors. Published by Elsevier B.V.

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Significance evaluation of Anti-Aging QOL Common Questionnaire.

Oguma, Y, Iida, K, Yonei, Y, Satoh, T

Glycative Stress Research 3(3): 177-185, 2016. （Society for Glycation Stress Research, Glycation Stress Research Center, Doshisha University） 3 （ 3 ） 177 - 185 2016年

ISSN 2188-3602