研究者詳細 - 小熊　祐子

論文 - 小熊　祐子

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An approach for the analysis of axonal neuroinflammation by measuring dual biomarkers of oligodendrocytes and inflammatory cytokine in human plasma

M Mitsuhashi, A Hirata, Y Oguma, H Ishida, K Kawata

Research square 2024年

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Association of polydoctoring and mortality among very old persons with multimorbidity: a prospective cohort study in Japan

T Ando, T Sasaki, Y Abe, Y Nishimoto, T Hirata, T Tajima, Y Oguma, ...

BJGP open 8 （ 3 ） 2024年

Background: Polydoctoring can increase the risk of care fragmentation among patients with multimorbidity, but its impact on health outcomes remains unclear. Aim: To determine the effects of polydoctoring, as measured by the regularly visited facilities (RVF) indicator, on patient outcomes among older individuals with multimorbidity. Design & setting: Data from the ongoing prospective cohort study, Kawasaki Aging and Wellbeing Project (KAWP), was utilised in this study. Among the 1026 KAWP participants aged 85–89 years, those with two or more chronic conditions were enrolled in this study. Method: Care fragmentation and polydoctoring was evaluated using the RVF, which is a new indicator that measures the number of medical facilities consistently involved in a patient’s care. Based on RVF, mortality was analysed using the Cox proportional hazards model, with adjustments for age, sex, frailty, and number of comorbidities. Results: A significant reduction in mortality rates was observed in participants with an RVF of ≥3 and 2–4 comorbidities (hazard ratio [HR] 0.43, 95% confidence interval [CI] = 0.18 to 0.99, P value = 0.048). However, no significant difference in mortality based on RVF was observed for those with ≥5 comorbidities. Notably, individuals with ≥5 comorbidities and an RVF of 0 had a significantly higher HR for death (HR 2.68, 95% CI = 1.05 to 6.84, P value = 0.039). Conclusion: In older patients with multimorbidity, polydoctoring may reduce mortality in patients with ≤4 coexisting conditions, but it does not significantly impact mortality in those with ≥5 conditions. These findings provide insights for healthcare decision making in managing older patients with multimorbidity.

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有疾患者を対象にした運動プログラム

小熊祐子

体力科学（一般社団法人日本体力医学会） 73 （ 1 ） 8 - 8 2024年

ISSN 0039906X

新たに公表される「健康づくりのための身体活動・座位行動指針」に関するインフォメーションシート

井上茂, 小熊祐子

体力科学（一般社団法人日本体力医学会） 73 （ 1 ） 26 - 26 2024年

ISSN 0039906X

慢性疾患を有する人における運動の重要性と安全に行うためのポイント

佐藤真治, 小熊祐子

体力科学（一般社団法人日本体力医学会） 73 （ 1 ） 18 - 18 2024年

ISSN 0039906X

安全・安心に運動を行うために

平田昂大, 小熊祐子, 黒瀬聖司, 齋藤義信, 佐藤真治, 都竹茂樹

体力科学（一般社団法人日本体力医学会） 73 （ 1 ） 19 - 19 2024年

ISSN 0039906X

慶應義塾大学体育会に所属する女子部員の月経状況とセルフケアに関する研究

奥山靜代, 東原綾子, 清水花菜, 板垣悦子, 佐々木玲子, 小熊祐子

体育研究所紀要（慶應義塾大学体育研究所） 63 （ 1 ） 13 - 21 2024年

ISSN 0286-6951

慶應義塾大学体育会に所属する女子部員を対象に、月経および月経随伴症状(PMS)等の実態やセルフケア等についてWebを用いての質問紙調査を実施した。調査期間は2022年11月から12月であった。121名(平均年齢19.9±1.1歳、平均身長160.8±5.3cm、平均体重53.1±5.7kg)から回答を得た。月経周期が25～38日の正常な対象者は98名、24日以下あるいは39日以上の月経周期異常の学生は19名、3ヵ月以上月経がない、いわゆる無月経と回答した学生は3名であった。月経の程度について、勉強・運動・仕事に支障があるかについて「支障はない」36名、「少し支障がある」54名、「横になって休憩する必要がある」20名、「1日以上寝込む」1名、「月経痛がまったくない」10名、との回答であった。62%の対象者が月経前の症状により競技パフォーマンスに障害を感じていると回答した。女子部員の約7割はPMS/PMDDに対策を全くしていないことが示された。

The relationship between dietary pattern and physical activity combinations to physical performance in 85+ Japanese population: A cross-sectional study from the TOOTH study

T Yu, Y Oguma, K Asakura, M Takayama, Y Abe, Y Arai

Archives of Gerontology and Geriatrics Plus 1 (3), 100038 2024年

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S08-3: Goals and realities in local goverments’ involvement in PA promotion for diverse populations subgroups–a comparative analysis of municipalities from 5 countries

P Sandu, P Gelius, S Messing, A Noel-Racine, Y Oguma, T Onatsu, ...

European Journal of Public Health 34 (Supplement_2), ckae114. 234 2024年

Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study

T Tajima, Y Oguma, Y Saito, Y Abe, IM Lee, Y Arai

The Journal of Frailty & Aging 13 (4), 413-420 2024年

Digital Peer-Supported App Intervention to Promote Physical Activity Among Community-Dwelling Older Adults: Nonrandomized Controlled Trial

Tabira K., Oguma Y., Yoshihara S., Shibuya M., Nakamura M., Doihara N., Hirata A., Manabe T.

JMIR Aging 7 e56184 2024年

Background: The use of mobile apps has promoted physical activity levels. Recently, with an increasing number of older adults accessing the internet, app-based interventions may be feasible in older populations. Peer support-based interventions have become a common method for promoting health-related behavior change. To our knowledge, the feasibility of using digital peer support apps (DPSAs) to increase physical activity among older adults and its impact on physical activity and physical function have not been investigated. Objective: This study aims to assess the feasibility of using DPSAs in older adults and to assess changes in physical activity and physical function in DPSA users. Methods: We conducted a nonrandomized controlled trial of older adults aged ≥65 years. We recruited participants for 2 distinct 12-week programs designed to increase physical activity. Participants could choose between an intervention group (app program and exercise instruction) or a control group (exercise instruction only). DPSA creates a group chat for up to 5 people with a common goal, and participants anonymously post to each other in the group. Once a day, participants posted a set of their step counts, photos, and comments on a group chat box. The intervention group used the DPSA after receiving 2 face-to-face lectures on its use. The participants were characterized using questionnaires, accelerometers, and physical function assessments. The feasibility of the DPSA was assessed using retention and adherence rates. Physical activity was assessed using accelerometers to measure the daily step count, light intensity physical activity, moderate to vigorous intensity physical activity (MVPA), and sedentary behavior. Physical function was assessed using grip strength and the 30-second chair-stand test. Results: The participants in the intervention group were more frequent users of apps, were more familiar with information and communication technology, and had a higher baseline physical activity level. The retention and adherence rates for the DPSA intervention were 88% (36/41) and 87.7%, respectively, indicating good feasibility. Participants in the intervention group increased their step count by at least 1000 steps and their MVPA by at least 10 minutes using the DPSA. There was a significant difference in the interaction between groups and intervention time points in the daily step count and MVPA (step count, P=.04; duration of MVPA, P=.02). The DPSA increased physical activity, especially in older adults with low baseline physical activity levels. Conclusions: The feasibility of DPSA was found to be good, with the intervention group showing increases in daily steps and MVPA. The effects of DPSA on step count, physical activity, and physical function in older adults with low baseline physical activity should be investigated using randomized controlled trials.

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Association between indoor temperature during winter and falls at home in the past year among community-dwelling older adults: a cross-sectional analysis of the nationwide …

M Ito, T Ikaga, Y Oguma, Y Saito, Y Fujino, S Ando, S Murakami

Nippon Ronen Igakkai Zasshi 61 (2), 218-227 2024年

Association between indoor temperature during winter and falls at home in the past year among community-dwelling older adults: A cross-sectional analysis of the nationwide Smart Wellness Housing survey in Japan

Ito M., Ikaga T., Oguma Y., Saito Y., Fujino Y., Ando S., Murakami S.

Japanese Journal of Geriatrics （一般社団法人日本老年医学会） 61 （ 2 ） 218 - 227 2024年

ISSN 03009173

Aim: Some studies have reported a higher incidence of falls during winter with similar proportions of indoor and outdoor falls. We investigated the relationship between indoor temperature during winter and falls at home in the past year among community-dwelling older adults. Methods: This cross-sectional study enrolled 964 individuals of ≥65 years of age in Japan. Participants answered questions about falls (including trips) at home within the past year, and the living room temperature was measured for 2 weeks during winter. Participants were divided into those living in cold (mean temperature near the floor <12̊C), slightly cold (12-17.9℃), and warm (≥18̊C) houses. The association between indoor temperature (cold vs. slightly cold vs. warm houses) and falls at home in the past year was examined using a logistic regression analysis adjusted for potential confounding factors. Results: Valid data were obtained from 907 participants (mean age: 72.0±6.3 years), of whom 265,553, and 89 lived in cold, slightly cold, and warm houses, respectively. In the past year, falls occurred once in 325 (35.8%) participants and multiple times in 148 (16.3%) participants. In warm houses, the odds ratio of falling once and multiple times in the past year was 0.49 (p=0.032) and 0.34 (p=0.035), respectively, in comparison to cold houses. Conclusions: Living in cold houses may be associated with an increased risk of falling at home among older adults. Maintaining an appropriate indoor thermal environment during winter may reduce the risk of falling among individuals who spend most of their time at home.

Does health literacy moderate the psychological pathways of physical activity from guideline awareness to behavior? A multi-group structural equation modeling

Tajima T., Harada K., Oguma Y., Sawada S.S.

BMC Public Health （BMC Public Health） 23 （ 1 ） 106 2023年12月

研究論文（学術雑誌）, 共著, 査読有り

Background: Awareness, knowledge, beliefs, and behavioral intentions of physical activity (PA) guidelines may be important mediating factors for promoting PA. However, these pathways of the psychological process to PA behavior have not been examined. These pathways may differ depending on health literacy levels. This study investigated the pathways to PA, from guideline awareness to behavior, and further examined whether they differed by health literacy. Methods: A cross-sectional study was conducted with 7,000 Japanese participants aged 20–69 years. The participants were registered with an Internet survey company. Participants’ awareness, knowledge, beliefs, and behavioral intentions regarding the PA guidelines of Japan, the volume of moderate-to-vigorous intensity PA, activity level, and health literacy were examined through a questionnaire. The PA pathways, from guideline awareness to behavior, were examined by structural equation modeling (SEM), with PA behavior as the dependent variable. Multi-group SEM was conducted to examine the moderating effect of health literacy on PA pathways. Health literacy scores were dichotomized into high and low groups in multi-group modeling by the median split. Results: SEM revealed that PA guideline awareness directly affects PA behavior and has certain indirect effects through the mediation of knowledge, beliefs, and behavioral intentions. Furthermore, the multi-group SEM showed that the proportion of indirect effects (path coefficient [PC]: 0.11, 95% confidence interval [CI]: 0.10–0.13) was higher than direct effects (PC: 0.07, 95%CI: 0.03–0.11) in the high-health literacy group. In contrast, the proportion of direct effects (PC: 0.22, 95%CI: 0.15–0.30) was higher than indirect effects (PC: 0.06, 95%CI: 0.05–0.07) in the low-health literacy group. Conclusions: PA guideline awareness is both directly and indirectly associated with PA behavior, mediated by psychological pathways of knowledge, beliefs, and behavioral intentions, and influenced by health literacy. These results suggest that health literacy should be considered when implementing PA guideline-based interventions.

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Characteristics Of Training Room Users And Adverse Events At A Community Healthcare Center

Hirata, A; Oguma, Y; Tanaka, A; Ogawa, Y; Himeno, H; Saito, Y; Sato, S; Tsuzuku, S; Kurose, S

MEDICINE & SCIENCE IN SPORTS & EXERCISE 55 （ 9 ） 1015 - 1017 2023年09月

ISSN 0195-9131

The Joint Association Of Physical Activity And Sedentary Behavior With Cardiorespiratory Fitness In Middle-aged Japanese: KZS Study

Zhai, XY; Sawada, SS; Kurosawa, S; Koriyama, S; Dimitroff, SA; Moniwa, Y; Oka, K; Oguma, Y; Sato, S; Maruo, K; Nakata, Y; Miyachi, M; Gando, Y; Lee, IM; Sui, XM

MEDICINE & SCIENCE IN SPORTS & EXERCISE 55 （ 9 ） 454 - 454 2023年09月

ISSN 0195-9131

Relationship between dietary patterns with subjectively measured physical activity in 85+years older

Yu, T; Oguma, Y; Asakura, K; Abe, Y; Arai, Y

ANNALS OF NUTRITION AND METABOLISM 79 896 - 896 2023年08月

ISSN 0250-6807

Plasma amino acid signature for sarcopenic phenotypes in community-dwelling octogenarians: Results from the Kawasaki Aging Wellbeing Project

Osawa Y., Candia J., Abe Y., Tajima T., Oguma Y., Arai Y.

Experimental Gerontology （Experimental Gerontology） 178 112230 2023年07月

研究論文（学術雑誌）, 査読有り, ISSN 05315565

Sarcopenia is one of the primary risk factors for various adverse health events in later life. However, its pathophysiology in the very old population remains unclear. Hence, this study aimed to examine whether plasma free amino acids (PFAAs) correlate with major sarcopenic phenotypes (i.e., muscle mass, muscle strength, and physical performance) in community-dwelling adults aged 85–89 years living in Japan. Cross-sectional data from the Kawasaki Aging Well-being Project were used. We included 133 adults aged 85–89 years. In this study, fasting blood was collected to measure 20 plasma PFAAs. Measures for the three major sarcopenic phenotypes included appendicular lean mass assessed by multifrequency bioimpedance, isometric handgrip strength, and gait speed from a 5 m walk at a usual pace. Furthermore, we used phenotype–specific elastic net regression models adjusted for age centered at 85 years, sex, body mass index, education level, smoking status, and drinking habit to identify significant PFAAs for each sarcopenic phenotype. Higher histidine and lower alanine levels were associated with poor gait speed, but no PFAAs correlated with muscle strength or mass. In conclusion, PFAAs such as plasma histidine and alanine are novel blood biomarkers associated with physical performance in community-dwelling adults aged 85 years or older.

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加速度計で調査した85-89歳地域在住高齢者の座位行動と関連要因の横断的検討　The Kawasaki Aging and Wellbeing Project

新村直子, 田島敬之, 齋藤義信, 於タオ, 吉田奈都子, 阿部由紀子, 新井康通, 小熊祐子

運動疫学研究: Research in Exercise Epidemiology （日本運動疫学会） 25 （ 1 ） 19 - 30 2023年06月

ISSN 1347-5827

目的:85-89歳の地域在住高齢者の座位行動を客観的に評価し,テレビ視聴時間を含む関連要因について多面的に検討する。方法:The Kawasaki Aging and Wellbeing Project(KAWP)のベースライン(2017-18年)調査の参加者1,026名に連続7日間の加速度計装着を依頼し,有効データ914名(女性473名)の座位行動を客観的に評価した。重回帰分析を男女別に行い,座位行動との関連要因を3領域(身体状況,社会経済状況,生活習慣)の24因子と年齢,計25因子から検討した。結果:総座位時間・装着時間に占める座位時間の割合は男性1日平均(標準偏差)9.4(1.9)時間・67%,女性8.6(1.8)時間・59%と男性が女性より長く座っており,30分以上継続する座位時間の割合も女性より高かった。重回帰分析により座位行動と関連が認められた要因は,関連が強い順に,男性ではテレビ視聴時間・BMI(正),家事時間・園芸スコア・運動時間・歩行速度・握力・ADL(負),女性ではBMI・テレビ視聴時間(正),家事時間・睡眠時間・運動時間・ADL・外出スコア(負)であった。結論:80歳代後半の地域在住高齢者の座位行動にはテレビ視聴以外に,BMI・歩行速度・握力・ADLなどの身体状況要因,家事・園芸・運動・睡眠・外出などの生活習慣要因が多面的に関連していた。(著者抄録)

断熱改修が成人における冬季の住宅内座位行動および身体活動に及ぼす影響　スマートウェルネス住宅調査による準実験的研究

伊藤真紀, 伊香賀俊治, 小熊祐子, 齋藤義信, 藤野善久, 安藤真太朗, 村上周三

運動疫学研究: Research in Exercise Epidemiology （日本運動疫学会） 25 （ 1 ） 50 - 63 2023年06月

ISSN 1347-5827

目的:断熱改修が冬季の住宅内の座位行動と身体活動に及ぼす影響を検討した。方法:断熱改修に意欲的な成人を募集し,冬季2週間のベースライン調査(改修前)と,その1～4年後の同時期に追跡調査(改修後)を行った。住宅内の座位時間と低強度以上の身体活動量(light-to-vigorous physical activity;LVPA)は,加速度計と外出記録から評価した。断熱改修を行った介入群と断念した対照群に対象者を分け,住宅内の座位時間とLVPAの変化との関連を線形混合モデルで検討した。また,脱衣所室温変化量[低下(-1℃未満),変化なし(-1℃以上+1℃未満),上昇小(+1℃以上+5℃未満),上昇大(+5℃以上)]を説明変数に加えた解析も実施した。結果:1,751名(介入群1,640名,対照群111名)を解析対象とした。脱衣所室温は介入群で有意に上昇したが,群間で調査期間のずれが生じたことなどにより,対照群の室温も外気温の上昇に伴い上昇していた。多変量解析の結果,断熱改修と住宅内の座位時間・LVPAの変化に有意な関連は認められなかった。ただし,脱衣所室温変化量は有意に関連していた。室温が変化しなかった場合に比べて,5℃以上改善した場合は,座位時間が減少し,LVPAは増加したが,室温が低下した場合には,座位時間が増加し,LVPAは減少した。結論:断熱改修は住宅内の座位時間とLVPAの変化に関連していなかった。ただし,脱衣所等の室温改善は,住宅内の座位行動を抑制し,LVPAを増加させる可能性が示唆された。今後も検証が必要である。(著者抄録)

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小熊 祐子

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論文 - 小熊　祐子