研究者詳細 - 梅田　聡

論文 - 梅田　聡

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品川和志, 板垣翼, 梅田聡

日本心理学会大会発表論文集（公益社団法人日本心理学会） 85 （ 0 ） PI-044 - PI-044 2021年

<p>マインドワンダリング（MW）研究では，課題中に提示されるプローブによってMWが捉えられる。そのため，実験中に提示されるプローブは，思考状態の正確な測定において重要である。これまでの手法では，課題集中あるいは課題無関連思考集中に二分するものが主流であった。しかし，思考状態は常にどちらかの思考に分類されるものではなく，複数の状態が共存することが考えられる。本研究では，Go/No-go課題を行っている最中に，思考状態の共存を認める思考プローブを提示し，検討を行った（N＝30）。結果として，複数の思考が共存しているという主観報告が得られた。一方で，主観報告が得られた背景にある状態を，隠れマルコフモデルを用いて推定すると，従来の手法同様，課題集中，MW，両者の中間という思考状態が推定された。さらに，MW状態である区間では他の状態と比較して，反応時間の分散の増加がみられた（F（2, 58）＝6.504, <i>p</i>＝.003）。従来のプローブ法と同様の状態が推定されたことから，従来の手法でもMWを十分捉えていると考えられるが，より正確にMWを捉えるためには，共存状態を考慮する必要があることが示唆された。</p>

β-Lactolin Enhances Neural Activity, Indicated by Event-Related P300 Amplitude, in Healthy Adults: A Randomized Controlled Trial

Kanatome A., Ano Y., Shinagawa K., Ide Y., Shibata M., Umeda S.

Journal of Alzheimer S Disease 81 （ 2 ） 787 - 796 2021年

査読有り, ISSN 13872877

Background: Epidemiological studies have shown that dairy product consumption is beneficial for cognitive function in elderly individuals. β-lactolin is a Gly-Thr-Trp-Tyr lacto-tetrapeptide rich in fermented dairy products that improves memory retrieval, attention, and executive function in older adults with subjective cognitive decline and prevents the pathology of Alzheimer's disease in rodents. There has been no study on the effects of β-lactolin on neural activity in humans. Objective: We investigated the effects of β-lactolin on neural activity and cognitive function in healthy adults. Methods: In this randomized, double-blind, placebo-controlled study, 30 participants (45-64 years old) consumed β-lactolin or placebo for 6 weeks. Neural activity during auditory and language tasks was measured through 64-channel electroencephalography. Moreover, verbal fluency tests were performed at baseline and after 6 weeks. Results: The β-lactolin group had a significantly higher P300 amplitude at the Cp2 site (a part of the parietal lobe near the center of brain, p=0.011), and C4 site (the area between the frontal and parietal lobe, p=0.02) during the auditory tasks after 6 weeks than the placebo group. Thus, β-lactolin supplementation promoted neural activity in the parietal area, which increases concentration and attention during auditory cognitive tasks. Compared with the placebo group, the β-lactolin group also showed significant changes in the scores of verbal fluency test after 6 weeks (p=0.033). Conclusion: Our findings provide insight into the mechanisms underlying the effects of β-lactolin on attention in healthy adults.

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過食性障害傾向者におけるリスクテイキング行動と内受容感覚に関する検討

若月葵, 梅田聡

日本心理学会大会発表論文集（公益社団法人日本心理学会） 85 （ 0 ） PD-079 - PD-079 2021年

過食性障害（BED）では，ネガティブな結果に至る可能性を認識しながらも過食に及ぶというリスクテイキング行動が見られる。リスクテイキング行動に先行する意思決定は，身体内部の変化に関する感覚である内受容感覚と関連するとされる。BEDでは内受容感覚の正確性の低下が報告されてきたが，いずれも主観報告に基づくものであり，課題による客観的な測定によって，BEDの意思決定と身体感覚との関連についてより詳細な議論が可能になる。本研究では，BED傾向者を対象にバルーンアナログリスクタスクと心拍検出課題を行い，BED傾向の高低による，リスクテイキング，および内受容感覚の客観的な正確さの違いを検討した。その結果，BED傾向高群の方がリスクテイキングがむしろ弱く，食べ物以外の文脈ではむしろリスクを回避する傾向が見られた。内受容感覚についてはBED傾向高群でより正確である傾向が見られ，先行研究で示された主観報告に基づく正確性の低下と併せて，主観報告と課題のそれぞれから得られる正確性の間に乖離がある可能性が示唆された。今回見られた傾向は，BEDにおける過食エピソードの生起において重要な役割を果たす可能性がある。

熟成ホップ由来苦味酸の継続摂取による認知機能改善

阿野泰久, 福田隆文, 梅田聡

アルコールと医学生物学（梵天書房） 39 126 - 126 2020年12月

顔面と指尖における皮膚血流反応の情動指標としての可能性

朝比奈正人, 石川直樹, 梅田聡

日本自律神経学会総会プログラム・抄録集（日本自律神経学会） 73回 113 - 113 2020年11月

情動を生み出す脳神経基盤と自律神経機能—Neural mechanisms of emotion and autonomic nervous activities—特集痛みと情動

梅田聡

脳神経内科 = Neurology / 脳神経内科編集委員会編（科学評論社） 93 （ 3 ） 316 - 321 2020年09月

ISSN 2434-3285

CiNii Research

共感場面における顔血流と指尖血流の関連性の検討

石川直樹, 朝比奈正人, 梅田聡

生理心理学と精神生理学（日本生理心理学会） 38 （ 2 ） 119 - 119 2020年08月

ISSN 0289-2405

Alterations of Heartbeat Evoked Magnetic Fields Induced by Sounds of Disgust

Kato Y., Takei Y., Umeda S., Mimura M., Fukuda M.

Frontiers in Psychiatry （Frontiers in Psychiatry） 11 683 - 683 2020年07月

査読有り

© Copyright © 2020 Kato, Takei, Umeda, Mimura and Fukuda. The majority of the models of emotional processing attribute subjective emotional feelings to physiological changes in the internal milieu, which are sensed by the interoceptive system. These physiological reactions evoked by emotional phenomena occur via the autonomic nervous system, and give rise to alterations in body-mind interactions that are characterized by heartbeat evoked magnetic fields (HEFs) involving brain regions associated with emotional perception. The current study used magnetoencephalography (MEG) to examine regional cortical activity and connectivity changes in HEFs provoked by the emotion of disgust. MEG results from 39 healthy subjects (22 female) revealed that passively listening to sounds of disgust elicited right insular cortical activity and enhancement of cortical connectivity between the right anterior ventral insular cortex and left ventromedial prefrontal cortex, demonstrated by phase lag indexes in the beta frequency range. Furthermore, inter-trial coherence significantly increased at 19 Hz and 23 Hz, and decreased at 14 Hz, which highlights the involvement of low beta oscillations in emotional processing. As these results were based on spontaneously triggered bioelectrical signals, more indigenous and induced signals were extracted with a block designed experiment. The insular cortices play an important role in emotional regulation and perception as the main cortical target for signals with interoceptive information, providing direct substrates of emotional feelings. The current results provide a novel insight into frequency properties of emotional processing, and suggest that emotional arousal evoked by listening to sounds of disgust partially impact the autonomic nervous system, altering HEFs via connectivity changes in the right anterior ventral insular cortex and left ventromedial prefrontal cortex.

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ホップ由来苦味酸の継続摂取による認知機能改善と消化管上皮細胞の活性化

阿野泰久, 福田隆文, 高橋千佳, 山崎雄大, 梅田聡

日本栄養・食糧学会大会講演要旨集（(公社)日本栄養・食糧学会） 74回 284 - 284 2020年04月

前頭極と頭頂葉内側部における記憶機能—Zentōkyoku to tōtyōyou naisokubu ni okeru kioku kinou—Memory functions in the frontal pole and the medial parietal areas

梅田, 聡

哲學（三田哲學會） 144 3 - 27 2020年03月

ISSN 0563-2099

type:text
This paper reviews memory functions in the frontal pole and the medial parietal areas. Many studies have focused on both areas through various approaches, including neuropsychology, neuroimaging, psychiatry, neurology, and neurosurgery. In addition to the memory-related functions, both areas have substantially quite complex
higher-order cognitive functions, including executive functions, multi-task processing, future-oriented cognition, self-related cognition, and spatial cognition. Here, I picked up some fundamental perspectives in each area by reviewing previous studies to elucidate how the areas relate memory processing and provide some facets for delineating the whole aspect of memory mechanisms.
特集 : 伊東裕司教授退職記念号
寄稿論文

CiNii Research

Neural and clinical changes of cognitive behavioural therapy versus talking control in patients with major depression: A study protocol for a randomised clinical trial

Katayama N., Nakagawa A., Abe T., Kurata C., Sasaki Y., Mitsuda D., Nakao S., Mizuno S., Ozawa M., Nakagawa Y., Ishikawa N., Umeda S., Terasawa Y., Tabuchi H., Kikuchi T., Mimura M.

BMJ Open （BMJ Open） 10 （ 2 ） e029735 2020年02月

査読有り

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. While major depression causes substantial distress and impairment for affected individuals and society, the effectiveness of cognitive behavioural therapy (CBT) in treating the condition has been established. However, the therapeutic mechanism underlying the efficacy of CBT remains unknown. This study aimed to describe a protocol for a randomised controlled trial that will measure the CBT-induced clinical and neural changes in patients with non-psychotic major depression. Methods and analysis The current study is a 16-week assessor-blinded, randomised, parallel-group trial with a 12-month follow-up as part of usual depression care at an outpatient clinic. Patients aged 20-69 years with major depressive disorder will be randomly assigned to receive either CBT in addition to their usual treatment or talking control in addition to their usual treatment for 16 weeks. The primary outcome is the functional changes in the brain areas that have been associated with future-oriented thinking at 16 weeks; secondary outcomes include changes in functional brain connectivity, severity and changes in the scores of objective and subjective clinical depression symptoms, proportion of responders and remitters and quality of life. The intention-to-treat analysis will be used. Ethics and dissemination All protocols and the informed consent form are compliant with the Ethics Guideline for Clinical Research (Japanese Ministry of Health, Labour and Welfare). Ethical Review Committees at the Keio University School of Medicine have approved the study protocol (version 3, 11 September 2017). We will disseminate research findings to scientific and general audiences through national and international conference presentations as well as lay summaries to the general public, including mental health consumer and publications in international peer-reviewed psychiatry and brain imaging journals. Trial registration number UMIN Clinical Trials Registry (UMIN000018155); Pre-results.

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Executive Function Evaluation System based on Wiping Desk Behavior in Virtual Space

Sho Ooi, Akihito Mihara, Mutsuo Sano, Hajime Tabuchi, Fumie Saito, Satoshi Umeda

9th International Conference on Intelligent Computing and Applications (ICICA 2019) （International Academy Publishing (IAP)） 9 （ 4 ） 149 - 159 2020年02月

査読有り

In this study, we report the development of a virtual reality (VR) system that evaluates executive function based on cleaning behaviors in real-time. It is known that patients with acquired brain injuries present adverse symptoms such as attention, memory, and functional disorders, as well as aphasia. Current methods to evaluate acquired brain injuries include tests such as the behavioral assessment of the dysexecutive syndrome (BADS) and digital clinical assessment for attention (D-CAT) tests; however, these tests require special/specific toolkits, and the methods are rigorous when applied for real-time dynamic evaluation. Moreover, patients are often burdened by the need to undergo paper tests as required by the evaluation methods. In this context, we propose and verify the efficacy of a method that offers real-time dynamic evaluation of acquired brain injury based on daily-living activities such as cooking, cleaning, and shopping. In this study, we focus on executive function relating to acquired brain injury, and we propose a real-time dynamic evaluation method for executive functioning using VR, which enables the automatic evaluation of subjects’ table-cleaning behavior. Our results indicate that our system can automatically assess subjects’ table cleaning behavior based on BADS test, while affording a cleaning behavior maximum average accuracy of 75.5%.

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Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial

Fukuda T., Obara K., Saito J., Umeda S., Ano Y.

Journal of Agricultural and Food Chemistry （Journal of Agricultural and Food Chemistry） 68 （ 1 ） 206 - 212 2020年01月

査読有り, ISSN 00218561

© 2019 American Chemical Society. The present study aimed to investigate the effects of matured hop bitter acids (MHBAs) on human cognition, mental fatigue, and mood state. In this randomized double-blind placebo-controlled study, 60 healthy adults (age 45-64 years) with self-awareness of cognitive decline were randomly divided into 2 groups and received either orally administered MHBAs (35 mg/day) or placebo for 12 weeks. Cognitive functions and mental states were assessed using neuropsychological tests or questionnaires at baseline and weeks 6 and 12 of the intervention. The change in verbal fluency score at week 6 compared with that at baseline was significantly higher in the MHBAs-treated group compared with that in the placebo group (P = 0.034), and Stroop test score at week 12 was significantly lower in the MHBAs-treated group compared with the placebo group (P = 0.019). Furthermore, subjective fatigue and anxiety at week 12 were significantly improved in the MHBAs-treated group (P = 0.008 and 0.043, respectively) compared with the placebo group. This is the first study to evaluate the effects of bitter ingredients in beer on cognition, subjective mood, and mental fatigue in a clinical trial. Our findings suggest that hop-derived bitter acids might be beneficial for cognition and mood state.

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Affective and temporal orientation of thoughts: Electrophysiological evidence

Ito Y., Shibata M., Tanaka Y., Terasawa Y., Umeda S.

Brain Research （Brain Research） 1719 148 - 156 2019年09月

査読有り, ISSN 00068993

© 2019 Elsevier B.V. The factors that determine the content and valence of spontaneous thoughts have not yet been clarified. In this study, we focused on the effects of bodily states and depression and anxiety traits. Participants performed a past/future thinking task in which three-part sentences including temporal cues were presented in a sequential pattern, for example “in the near future/dreams/will come true”. We measured heartbeat-evoked potentials (HEPs)to assess affective processing, and event-related potentials (ERPs)to assess temporal processing of thoughts that emerged when the temporal cue words were presented. The HEPs predicted thought valence irrespective of personality traits. Larger N400 ERPs were observed in response to past-oriented than to future-oriented words in participants with higher levels of depression, whereas the opposite was the case in participants with higher social anxiety. Our data suggest that afferent signals modulate affective thought-orientations as triggers, and that individuals with depression and anxiety have sensitivity toward temporal information at the neural level.

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脳波を用いたノイズ感受性の神経メカニズムの検討

小髙真奈, 柴田みどり, 伊藤友一, 田仲祐登, 辻幸樹, 品川和志, 寺澤悠理, 梅田聡

日本心理学会大会発表論文集（公益社団法人日本心理学会） 83 2B-038 - 2B-038 2019年09月

AFFECTIVE PROCESSING AND SELF/OTHER IN FUTURE THINKING: AN HEP STUDY

Yuichi Ito, Yuto Tanaka, Koki Tsuji, Kazushi Shinagawa, Midori Shibata, Yuri Terasawa, Satoshi Umeda

PSYCHOPHYSIOLOGY 56 S77 - S77 2019年09月

ISSN 0048-5772

CHANGE OF NEURAL ACTIVITY TOWARD AWARENESS OF MIND WANDERING: AN ERP STUDY

Kazushi Shinagawa, Yuichi Ito, Koki Tsuji, Yuto Tanaka, Mana Odaka, Midori Shibata, Yuri Terasawa, Satoshi Umeda

PSYCHOPHYSIOLOGY 56 S61 - S61 2019年09月

ISSN 0048-5772

VR Executive Function Training System based on Cleaning Task

Shohei Namisato, Sho Ooi, Mutsuo Sano, Takumi Tsujimura, Satoshi Umeda, Hajime Tabuchi, Fumie Saito

The Seventh Annual Conference on Advances in Cognitive Systems (ACS) 292 - 307 2019年08月

査読有り

慢性頭痛患者における内受容感覚

朝比奈正人, 田仲祐登, 辻幸樹, 寺澤悠理, 梅田聡

日本頭痛学会誌（(一社)日本頭痛学会） 46 （ 1 ） 225 - 229 2019年08月

ISSN 1345-6547

Anterior insular cortex stimulation and its effects on emotion recognition

Motomura K., Terasawa Y., Natsume A., Iijima K., Chalise L., Sugiura J., Yamamoto H., Koyama K., Wakabayashi T., Umeda S.

Brain Structure and Function （Brain Structure and Function） 224 （ 6 ） 2167 - 2181 2019年07月

査読有り, ISSN 18632653

© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. With the objective to investigate the role of the insula in recognizing emotion, we performed direct electrical stimulation over the anterior insular cortex during awake surgery while simultaneously delivering an emotional sensitivity task. We registered 18 consecutive patients with brain tumors associated with the insular lobe, who were undergoing tumor resection. An emotional sensitivity task was employed to measure the patients’ ability to recognize emotions from facial expressions before, during, and after awake surgery. Furthermore, we performed voxel-based lesion symptom mapping (VLSM) to identify the association between relevant brain lesions and emotion recognition. When we performed direct electrical stimulation over the anterior insular cortex during awake surgery, the results showed that the ability to recognize anger was significantly enhanced with the presence of anterior insular stimulation (p < 0.05). Comparing the performance in the emotional sensitivity task before and after surgery, the performance in the anger condition became worse (p < 0.01), but became better in the sadness condition after surgery (p < 0.01). In the case of anger recognition, lower scores in the correct response index were associated with lesions involving the left insula in the VLSM study. Direct electrical stimulation over the anterior insular cortex enhanced anger recognition in patients with insular tumors. In contrast, accuracy of anger recognition was significantly reduced, and sadness was improved, when the performance of emotional sensitivity was compared pre- and post-surgery. Our findings suggest that the insular cortex is involved in changes in emotion recognition, including anger and sadness recognition by modulating arousal level that is closely connected with interoception.

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梅田 聡

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論文 - 梅田　聡