研究者詳細 - 梅田　聡

論文 - 梅田　聡

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Heartbeat evoked potentials reflect interoceptive awareness during an emotional situation

Tanaka Y., Ito Y., Shibata M., Terasawa Y., Umeda S.

Scientific Reports 15 （ 1 ） 2025年12月

Interoception, the ability to perceive internal bodily signals, involves various mental processes. This study investigated moments when individuals experienced a change in their interoceptive state. Interoception affects the subjective feelings of emotions. However, whether changes in interoceptive processing occur when visceral changes are perceived as interoceptive sensations remains unclear. This study examined the psychophysiological markers of perceptual changes in the interoceptive state using heartbeat evoked potentials (HEP). Emotional photos were viewed by participants who were asked whether they experienced changes in their interoceptive state. The results showed that the HEP amplitude increased when participants had subjective awareness of changes in their interoceptive state. Notably, the HEP amplitude did not correlate with individual differences in interoceptive accuracy measured by the heartbeat counting task. When individuals perceive changes in their interoceptive state, this perception is reflected in the HEP amplitude. Multiple aspects of interoception are related to the emotional recognition and conscious attention to changing bodily states.

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心理的な痛みの認知神経メカニズム

梅田聡

心身医学（一般社団法人日本心身医学会） 65 （ 4 ） 308 - 315 2025年07月

ISSN 03850307

<p>本稿では，まず主観的な感覚である心理的な痛みの定義およびその原因となる要因について述べ，痛みの症状を生み出す認知神経メカニズムについて概説する．特に，島皮質および帯状皮質前部から構成されるセイリエンスネットワークを中心とした神経基盤の関与について，内受容感覚との関連性に着目しながら述べる．さらに，慢性的な痛みを解釈する認知神経科学の理論的枠組みを紹介し，内受容感覚のベースとなる自律神経活動の特殊性に焦点を当て，身体症状症をはじめとする臨床病態について考察する．</p>

脳機能ネットワークの知見とその臨床への展開可能性

梅田聡, 月浦崇

神経心理学（日本神経心理学会） 40 （ 4 ） 291 - 293 2024年12月

ISSN 09111085

Supplementation with whey peptide rich in β-lactolin improves trait anxiety and subjective stress in healthy adults: a randomized, double-blind, placebo-controlled study

Ayabe T., Shinohara M., Kita M., Takahashi C., Saito J., Furuyashiki T., Toba K., Umeda S., Ano Y.

Scientific Reports 14 （ 1 ） 2024年12月

Mental disorders have become one of the most burdensome health concerns. We have previously demonstrated that whey-derived β-lactolin (glycine–thereonine–tryptophan–tyrosine tetrapeptide) activates dopaminergic systems and improves psychiatric function in rodents. However, the effects of β-lactolin on human mood states have not been investigated. This randomized, double-blind, placebo-controlled study aimed to evaluate the effects of supplementation with β-lactolin–rich whey peptide on human mood states. Sixty healthy adults (aged 45–64 years) with relatively low psychological health were randomly allocated to receive either whey peptide (containing β-lactolin 1.6 mg/day) or placebo for 6 weeks. Mood states (primary outcomes) were evaluated using self-reporting questionnaires. Health-related quality of life (QOL), salivary stress marker and lipid mediator levels were evaluated as secondary outcomes. Compared with placebo, supplementation with β-lactolin improved changes in trait anxiety (p = 0.046), as assessed using the state–trait anxiety inventory, and in subjective stress (p = 0.043), as assessed using the Perceived Stress Scale. In the assessment of QOL, changes in the vitality subscale and mental health summary score of the 36-Item Short-Form Health Survey were improved in the β-lactolin group. The levels of salivary immunoglobulin A were significantly higher in the β-lactolin group. In a subgroup analysis by median age (54.5 years), subjective stress and salivary prostaglandin levels were significantly decreased by β-lactolin supplementation in the 45–54 -year-old subgroup. In conclusion, supplementation with β-lactolin improves trait anxiety, subjective stress, and psychological QOL, which may be associated with immunologic responses detected via salivary analysis.

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右後頭顔領域の新規脳梗塞により相貌失認および表情認知の困難さを呈した1例

澤木優治, 寺澤悠理, 梅田聡, 本村和也, 山本裕泰, 山本正彦, 山内崇弘

脳卒中（(一社)日本脳卒中学会） 46 （ 6 ） 443 - 452 2024年11月

ISSN 0912-0726

広範な陳旧性の左後頭葉梗塞に加え,右後頭葉外側の新規脳梗塞にて熟知相貌に対する相貌失認を呈した症例を報告した.症例は70歳代の右利き男性であった.熟知相貌および表情の認知に困難さを認め,全般性注意機能,処理速度の低下がみられた.全般性認知機能および相貌認知以外の視覚認知機能は保たれていた.相貌失認は左右半球の後頭顔領域,紡錘状回顔領域,前部側頭葉の脳内ネットワークに機能不全が生じたことで発現したと考えられた.老若および性別の判断に関する相貌認知は保たれていた.拡散テンソルトラクトグラフィにより,右半球の下前頭後頭束や下縦束の白質線維が温存されたことが要因であると考えられた.さらに,全般性注意機能および処理速度の向上を図る認知リハビリテーション介入によって,表情認知の改善が得られる可能性が示唆された.(著者抄録)

Effects of unconscious tactile stimuli on autonomic nervous activity and afferent signal processing

Sakuragi M., Tanaka Y., Shinagawa K., Tsuji K., Umeda S.

International Journal of Psychophysiology 205 2024年11月

ISSN 01678760

Autonomic nervous system (ANS) is a mechanism that regulates our internal environment. In recent years, the interest in how tactile stimuli presented directly to the body affect ANS function and cortical processing in humans has been renewed. However, it is not yet clear how subtle tactile stimuli below the level of consciousness affect human heart rate and cortical processing. To examine this, subthreshold electrical stimuli were presented to the left forearm of 43 participants during an image-viewing task, and electrocardiogram (ECG) and electroencephalogram (EEG) data were collected. The changes in the R-wave interval of the ECG immediately after the subthreshold electrical presentation and heartbeat-evoked potential (HEP), the afferent signal processing of cardiac activity, were measured. The results showed that heart rate decelerated immediately after the presentation of subthreshold electrical stimuli. The HEP during stimulus presentation was amplified for participants with greater heart rate acceleration immediately after this deceleration. The magnitude of these effects depended on the type of the subthreshold tactile stimuli. The results suggest that even with subthreshold stimulation, the changes in autonomic activity associated with orienting response and related afferent signal processing differ depending on the clarity of the tactile stimuli.

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The body mirroring thought: The relationship between thought transitions and fluctuations in autonomic nervous activity mediated by interoception

Sakuragi M., Shinagawa K., Terasawa Y., Umeda S.

Consciousness and Cognition 125 2024年10月

ISSN 10538100

Our thought states change without intention. This study verified that the transition of thought states varies with fluctuations in autonomic nervous activity, and that this effect is modulated by interoceptive accuracy. The participants completed the heartbeat counting task (HCT) and vigilance task. We assessed the participants’ interoceptive accuracy based on their performance on the HCT. The vigilance task is a simple attention task, and during this task, we asked the participants to report the content and contemplation of their thoughts. Consequently, participants with accurate interoception were more likely to remain in a highly contemplative thought state when parasympathetic activity was suppressed. In contrast, the dominance of parasympathetic activity facilitated transitions to different thought states or experiences of less contemplative thought states in them. The results suggest that even subtle changes in bodily responses at rest can affect thought transitions in people with accurate interoception.

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時間的ドップラー効果に対する内受容感覚の影響の実験的検討

王馨怡, 石川直樹, 梅田聡

日本認知心理学会発表論文集（日本認知心理学会） 2024 （ 0 ） 20 - 20 2024年

我々は日常的に様々なイベントを経験するが，その経験前から、経験後にかけて、イベントに対する主観的な時間的距離を知覚している。経験前の時点からイベントまでに感じる時間的距離は、経験後の時点からイベントまでに感じる時間的距離よりも過小評価されるという非対称性があり、これを時間的ドップラー効果という。本研究では、実際にストレスイベントを経験させ、イベント前後におけるイベントまでの時間的距離の主観的な感覚をイベント前後20分、前後14分、前後3分という時点で追跡した。加えて内受容感覚の正確さおよび敏感さをそれぞれ心拍検出課題とBPQによって測定した。その結果、イベント前後20分、14分においては、時間的ドップラー効果が生じていたほか、内受容感覚においては敏感さ（BPQ）がイベント経験後における、イベントまでの時間的距離の感覚に影響を及ぼしていた。
本発表では実際に経験させたイベントにおける時間的ドップラー効果の存在について、個人の内受容感覚の影響や同時に測定した生理学的指標変動という点を踏まえて、時間的ドップラー効果のメカニズムについて議論する。

内受容感覚がストレス負荷時の感情状態および心血管反応に与える影響：連続血圧を用いた検討

田仲祐登, 品川和志, 辻幸樹, 梅田聡

日本認知心理学会発表論文集（日本認知心理学会） 2024 （ 0 ） 36 - 36 2024年

日常生活ではさまざまなストレス負荷が生じているが，同じ経験であったとしても感情体験には個人差が生じている．感情体験における個人差および自律神経反応には，身体内部の状態の知覚である内受容感覚が関係すると考えられる．本研究ではポジティブおよびネガティブなストレス負荷がかかったときの感情評価と連続血圧の変化に，内受容感覚がどのように関わっているのかについて検討を行った．参加者は，時事問題についてのパブリックスピーチ，プライベートな話題に関するスピーチ，およびテレビゲームを行い，課題実施前後に感情状態の評定を行うとともに，連続血圧の測定を行った．内受容感覚の指標として，心拍カウント課題と，MAIAを用いた．結果として，課題の種類によって課題前後の連続血圧の変化に違いが見られており，実験操作の効果が実証された．本発表では，その傾向と内受容感覚指標および感情評価との関連について議論する．

他者の感情観察時の顔血流の動態からみる社交不安症

石川直樹, 梅田聡

日本心理学会大会発表論文集（公益社団法人日本心理学会） 88 （ 0 ） 1C-056-PG - 1C-056-PG 2024年

人と共生・共進化するロボットのあり方に関する検討

熊谷和実, チャンポーンパックディーインオン, 三宅太文, 王語詩, 李思侠, 神藤駿介, 高田勝悟, 大畑昌輝, 富樫昌哉, 三宅徳久, 西村拓一, 宮尾祐介, 岡田将吾, 梅田聡, 田中聡久, 松本治, 尾形哲也, 菅野重樹, 大武美保子

ロボティクス・メカトロニクス講演会講演概要集（一般社団法人日本機械学会） 2024 （ 0 ） 1P2-D01 2024年

<p>This paper discuss the image of robot and human in the future and reports the demonstration conducted as a proposal for the vision of robots that coexist with an user and encourage positive behavior. As the progress of aging society, we propose that the robot coexist with an user at home is required to have functions: estimating an user mental or physical state, and advising the user to do appropriate behavior so that keep/improve their mental or physical state. We conducted demonstrations to recreate several scenes as a proposal for the future coexistence of robots and humans at home. This paper also reports about the constructed robot system and the results of generated robot behaviors.</p>

自律神経活動のゆらぎと思考遷移の関係

櫻木麻衣, 品川和志, 梅田聡

日本認知心理学会発表論文集（日本認知心理学会） 2024 （ 0 ） 97 - 97 2024年

私たちの思考の内容や，思考に対する集中度合いの強さは，いつの間にか変化する。この2つの指標の変動性は，自律神経活動のゆらぎと関連することが知られている。しかし，両者がどのような過程を経て対応づけられるのかは未だ不明である。本研究では，単純注意課題中に，参加者の思考内容と熟考性（思考に対する集中度合いの主観的評価）の時系列データを取得した。隠れマルコフモデルを用いて，2つの指標の系列の背後にある思考状態の遷移系列を推定した。思考状態の遷移パターンに基づき，参加者を3つのクラスターに分類した。その結果，思考状態の変動性が高いクラスターにおいて，心臓内受容感覚の正確さ（心拍検出の正確性）が高いほど，思考状態の遷移確率が高い傾向があることが分かった。このことは，思考の変動に対応する心拍変化があり，それを捉えやすい人ほど，思考状態の遷移が継続的に生じやすい可能性を示唆している。

身体症状症における反応攻撃性と主観的認知傾向の関連性

有馬彩乃, 梅田聡

日本心理学会大会発表論文集（公益社団法人日本心理学会） 88 （ 0 ） 2B-064-PM - 2B-064-PM 2024年

Coexistence of thought types as an attentional state during a sustained attention task

Shinagawa K., Itagaki Y., Umeda S.

Scientific Reports 13 （ 1 ） 2023年12月

Some studies have asked participants about attentional state on a scale from on-task to off-task, which set the middle option as attention focused on both, including the possibility of the coexistence of thoughts. In addition, studies using multidimensional probes explicitly assumed coexistence within spontaneous thoughts and task-focus dimensions. Although several studies have assumed the coexistence of some thought dimensions, none has explored whether these are different types of thoughts (task-focus, mind-wandering, task-related, external stimuli-related). To examine whether this coexistence of thought types occurred, we used thought probes to determine the degree of immersion in each. The participants responded to probes presented at random during a sustained attention task. The results revealed a mixture of thought types in many self-reports. In addition, the state of attentional allocation behind self-reports was estimated using the hidden Markov model. We observed the following attentional states: task-focused, task-unrelated, task-related, external stimuli-focused, and task-focused—but also focused on other thoughts. These results suggest that individuals can simultaneously allocate attention to thought types and discriminate between reporting. In some cases, probe options should also be considered for this coexistence. We also examined the relationship between self-reports and behavioral indexes, and discussed the necessity of separately measuring the degree of immersion for each thought type.

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Effect of subconscious changes in bodily response on thought shifting in people with accurate interoception

Sakuragi M., Shinagawa K., Terasawa Y., Umeda S.

Scientific Reports 13 （ 1 ） 2023年12月

Our thought states shift from one state to another from moment to moment. The relationship between the thought shifting and bodily responses is yet to be directly examined. This exploratory study examined the influence of cardiovascular reactivity and interoception—sensing an internal bodily state—on the shifting of thought states. Participants (N = 100, 70 women) completed two tasks: the heartbeat counting task (HCT) and the vigilance task (VT). We assessed their interoceptive accuracy through their performance on the HCT. The VT was a simple sustained attention task in which participants pressed a key when the target stimulus appeared and were asked to report their thoughts. We presented subliminal vibration stimuli to induce alterations in heart rate (i.e., vibration block). Results showed that participants with higher interoceptive accuracy reported more continuation of self-referential thought (about past episodes and future plans regarding themselves) during the vibration block than did those with lower interoceptive accuracy. These results suggest that individuals with higher interoceptive accuracy are more likely to be influenced by their subliminal bodily response, resulting in divergent attention from the task and intermittent self-referential thought.

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Modulation of heartbeat-evoked potential and cardiac cycle effect by auditory stimuli

Tanaka Y., Ito Y., Terasawa Y., Umeda S.

Biological Psychology 182 2023年09月

ISSN 03010511

Interoception has been proposed as a factor that influences various psychological processes (Khalsa et al., 2018). Afferent signals from the cardiovascular system vary across cardiac cycle phases. Heartbeat-evoked potentials (HEP) and event-related potentials (ERP) were measured to examine whether interoceptive signals differed between cardiac cycle phases. Simultaneously, participants performed an auditory oddball task in which the timing of the presenting stimulus was synchronized with the heartbeat. Pure tones were presented at 10 ms (late diastole condition), 200 ms (systole condition), or 500 ms after the R wave (diastole condition). Greater HEP amplitudes were observed when the tone was presented during diastole than during systole or late diastole. ERP showed the same tendency: a greater amplitude was observed during diastole than systole or late diastole. These results suggest that the processing of interoception reflected by HEP and exteroception reflected by ERP share attentional resources when both stimuli coincide. When the tone was presented during systole, attention to the internal state decreased compared with when the tone was presented during diastole, and attention was distributed to both exteroception and interoception. Our study suggests that HEP may be considered an indication of a relative amount of resources to process the interoception.

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Functional connectivity changes between frontopolar cortex and nucleus accumbens following cognitive behavioral therapy in major depression: A randomized clinical trial

Katayama N., Nakagawa A., Umeda S., Terasawa Y., Shinagawa K., Kikuchi T., Tabuchi H., Abe T., Mimura M.

Psychiatry Research Neuroimaging 332 2023年07月

ISSN 09254927

Cognitive behavioral therapy (CBT) is a psychotherapy that challenges distorted cognitions; however, the neural mechanisms that underpin CBT remain unclear. Hence, we aimed to assess the treatment-related resting-state functional connectivity (rsFC) changes in the brain regions associated with future thinking and the associations between rsFC changes and clinical improvements. Thirty-eight adult patients with MDD were randomly assigned with equal likelihood to receive 16-week individual CBT or talking control with a 12-month follow-up period. We evaluated the rsFC changes in the frontal regions, nucleus accumbens, amygdala, and limbic structures key to the depression pathophysiology and future thinking with 2 × 2 mixed ANOVA interaction analysis. Pearson's correlation analysis with Bonferroni's correction was also performed to examine the associations with clinical symptoms, such as depression severity and automatic thoughts in follow-up evaluations. Treatment-specific changes include enhancement in frontopolar connectivity with the nucleus accumbens. An increased rsFC was associated with lower negative automatic thoughts postoperatively, together with lower depressive symptoms and higher positive automatic thoughts at follow-up. Conclusively, rsFC changes in the fronto-limbic neural control circuit after CBT, particularly between the frontal pole and nucleus accumbens, may be clinically meaningful functional changes related to the depression recovery process.

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第1土曜特集自律神経のサイエンス自律神経の中枢制御自律神経系と予測処理機能

朝比奈正人, 梅田聡

医学のあゆみ（医歯薬出版） 285 （ 6 ） 522 - 528 2023年05月

ISSN 00392359

特集慢性疼痛心理的な痛みの機序

梅田聡

BRAIN and NERVE （株式会社医学書院） 75 （ 3 ） 243 - 252 2023年03月

ISSN 18816096

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

Amano M., Katayama N., Umeda S., Terasawa Y., Tabuchi H., Kikuchi T., Abe T., Mimura M., Nakagawa A.

Frontiers in Psychiatry 14 2023年01月

Background: Pessimistic thinking about the future is one of the cardinal symptoms of major depression. Few studies have assessed changes in pessimistic thinking after undergoing cognitive behavioral therapy (CBT). A randomized clinical trial (RCT) was conducted with patients diagnosed with major depressive disorder (MDD) to determine whether receiving a course of CBT affects pessimistic future thinking using a future thinking task. Methods: Thirty-one patients with MDD were randomly assigned to either CBT (n = 16) or a talking control (TC) (n = 15) for a 16-week intervention. The main outcomes were the change in response time (RT) and the ratio of the responses for positive valence, measured by the future thinking task. Secondary outcomes included the GRID-Hamilton Depression Rating Scale, the Beck Depression Inventory-Second Edition (BDI-II), the Dysfunctional Attitude Scale (DAS), and the word fluency test (WFT). Results: Regarding the main outcomes, the CBT group showed reduced RT for the positive valence (within-group Cohen’s d = 0.7, p = 0.012) and negative valence (within-group Cohen’s d = 0.6, p = 0.03) in the distant future condition. The ratio of positive valence responses in both groups for all temporal conditions except for the distant past condition increased within group (distant future: CBT: Cohen’s d = 0.5, p = 0.04; TC: Cohen’s d = 0.8, p = 0.008; near future: CBT: Cohen’s d = 1.0, p < 0.001; TC: Cohen’s d = 1.1, p = 0.001; near past: CBT: Cohen’s d = 0.8, p = 0.005; TC: Cohen’s d = 1.0, p = 0.002). As for secondary outcomes, the CBT group showed greater improvement than the TC group regarding the need for social approval as measured by the DAS (p = 0.012). Conclusion: Patients with MDD who received CBT showed a reduced RT for the positive and negative valence in the distant future condition. RT in the future thinking task for depressed patients may be a potential objective measure for the CBT treatment process. Because the present RCT is positioned as a pilot RCT, a confirmatory trial with a larger number of patients is warranted to elucidate the CBT treatment process that influences future thinking. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000021028, identifier UMIN000018155.

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