論文 - 梅田　聡

Effect of subconscious changes in bodily response on thought shifting in people with accurate interoception

Sakuragi M., Shinagawa K., Terasawa Y., Umeda S.

Scientific Reports 13 （ 1 ） 16651 - 16651 2023年12月

査読有り,  ISSN  2045-2322

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Our thought states shift from one state to another from moment to moment. The relationship between the thought shifting and bodily responses is yet to be directly examined. This exploratory study examined the influence of cardiovascular reactivity and interoception—sensing an internal bodily state—on the shifting of thought states. Participants (N = 100, 70 women) completed two tasks: the heartbeat counting task (HCT) and the vigilance task (VT). We assessed their interoceptive accuracy through their performance on the HCT. The VT was a simple sustained attention task in which participants pressed a key when the target stimulus appeared and were asked to report their thoughts. We presented subliminal vibration stimuli to induce alterations in heart rate (i.e., vibration block). Results showed that participants with higher interoceptive accuracy reported more continuation of self-referential thought (about past episodes and future plans regarding themselves) during the vibration block than did those with lower interoceptive accuracy. These results suggest that individuals with higher interoceptive accuracy are more likely to be influenced by their subliminal bodily response, resulting in divergent attention from the task and intermittent self-referential thought.

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うつ病の認知行動療法における未来に対する否定的な認知と反芻思考との関連

天野 瑞紀, 中川 敦夫, 片山 奈理子, 小林 由季, 小澤 満玲, 梅田 聡, 寺澤 悠理, 田渕 肇, 菊地 俊暁, 三村 將

日本認知療法・認知行動療法学会プログラム・抄録集 （日本認知療法・認知行動療法学会）  23回   260 - 260 2023年11月

Modulation of heartbeat-evoked potential and cardiac cycle effect by auditory stimuli

Tanaka Y., Ito Y., Terasawa Y., Umeda S.

Biological Psychology 182   108637 - 108637 2023年09月

査読有り,  ISSN  03010511

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Interoception has been proposed as a factor that influences various psychological processes (Khalsa et al., 2018). Afferent signals from the cardiovascular system vary across cardiac cycle phases. Heartbeat-evoked potentials (HEP) and event-related potentials (ERP) were measured to examine whether interoceptive signals differed between cardiac cycle phases. Simultaneously, participants performed an auditory oddball task in which the timing of the presenting stimulus was synchronized with the heartbeat. Pure tones were presented at 10 ms (late diastole condition), 200 ms (systole condition), or 500 ms after the R wave (diastole condition). Greater HEP amplitudes were observed when the tone was presented during diastole than during systole or late diastole. ERP showed the same tendency: a greater amplitude was observed during diastole than systole or late diastole. These results suggest that the processing of interoception reflected by HEP and exteroception reflected by ERP share attentional resources when both stimuli coincide. When the tone was presented during systole, attention to the internal state decreased compared with when the tone was presented during diastole, and attention was distributed to both exteroception and interoception. Our study suggests that HEP may be considered an indication of a relative amount of resources to process the interoception.

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INTEROCEPTION TRIGGERS THOUGHTS ABOUT THE SELF

Sakuragi, M; Shinagawa, K; Terasawa, Y; Umeda, S

PSYCHOPHYSIOLOGY 60   S171 - S171 2023年08月

ISSN  0048-5772

EXPLORATION OF IMPROVEMENT IN THE HEARTBEAT COUNTING TASK: EVALUATION OF TASK PERFORMANCE BY SIMULATION

Shinagawa, K; Sakuragi, M; Ishikawa, N; Terasawa, Y; Umeda, S

PSYCHOPHYSIOLOGY 60   S123 - S123 2023年08月

ISSN  0048-5772

【時間の神経科学-時を生み出すこころと脳の仕組み】障がいと神経学　未来に向けられた認知の神経メカニズム

梅田 聡

Clinical Neuroscience （(株)中外医学社）  41 （ 8 ） 1090 - 1093 2023年08月

ISSN  0289-0585

β-Lactolin, a novel whey-derived peptide, improves mood states and enteric microbiome metabolites: A randomized placebo-controlled trial.

Ano, Y; Ayabe, T; Saito, J; Umeda, S; Toba, K

ANNALS OF NUTRITION AND METABOLISM 79   399 - 399 2023年08月

ISSN  0250-6807

Functional connectivity changes between frontopolar cortex and nucleus accumbens following cognitive behavioral therapy in major depression: A randomized clinical trial

Katayama N., Nakagawa A., Umeda S., Terasawa Y., Shinagawa K., Kikuchi T., Tabuchi H., Abe T., Mimura M.

Psychiatry Research Neuroimaging （Elsevier BV）  332   111643 - 111643 2023年07月

査読有り,  ISSN  09254927

　概要を見る

Cognitive behavioral therapy (CBT) is a psychotherapy that challenges distorted cognitions; however, the neural mechanisms that underpin CBT remain unclear. Hence, we aimed to assess the treatment-related resting-state functional connectivity (rsFC) changes in the brain regions associated with future thinking and the associations between rsFC changes and clinical improvements. Thirty-eight adult patients with MDD were randomly assigned with equal likelihood to receive 16-week individual CBT or talking control with a 12-month follow-up period. We evaluated the rsFC changes in the frontal regions, nucleus accumbens, amygdala, and limbic structures key to the depression pathophysiology and future thinking with 2 × 2 mixed ANOVA interaction analysis. Pearson's correlation analysis with Bonferroni's correction was also performed to examine the associations with clinical symptoms, such as depression severity and automatic thoughts in follow-up evaluations. Treatment-specific changes include enhancement in frontopolar connectivity with the nucleus accumbens. An increased rsFC was associated with lower negative automatic thoughts postoperatively, together with lower depressive symptoms and higher positive automatic thoughts at follow-up. Conclusively, rsFC changes in the fronto-limbic neural control circuit after CBT, particularly between the frontal pole and nucleus accumbens, may be clinically meaningful functional changes related to the depression recovery process.

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【神経疾患の自律神経障害】自律神経が関与する情動・感情の障害とそのメカニズム

梅田 聡

脳神経内科 （(有)科学評論社）  99 （ 1 ） 27 - 33 2023年07月

ISSN  2434-3285

第1土曜特集 自律神経のサイエンス 自律神経の中枢制御 自律神経系と予測処理機能

朝比奈 正人, 梅田 聡

医学のあゆみ （医歯薬出版）  285 （ 6 ） 522 - 528 2023年05月

ISSN  00392359

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【自律神経のサイエンス】自律神経の中枢制御　自律神経系と予測処理機能

朝比奈 正人, 梅田 聡

医学のあゆみ （医歯薬出版(株)）  285 （ 6 ） 522 - 528 2023年05月

ISSN  0039-2359

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広く知られるホメオスタシスの概念の影響で身体の内部環境は一定であると思われがちであるが,実際には一定の幅で変動する.この変動はさまざまな因子により生じ,そのひとつは情動である.情動は闘争・逃走行動などの情動行動を伴い,その遂行には自律神経活動や内分泌活動による身体の生理学的変化を必要とする.身の危険を察知した際に,闘争・逃走行動を起こす前から身体の生理学的変化は生じており,それは自律神経系の予測的活動といえる.情動と自律神経活動は一体のものであり,そこで重要な働きをするのが辺縁系である.辺縁系は情動行動の遂行のために事前に自律神経反射のセットポイントを変化させる.ストレスに曝露した際に辺縁系が主体となり予測的に内部環境を変化させて情動行動を円滑に行えるようにする機構があると推察される.ストレス負荷により内部環境が変化する現象をアロスタシス(allostasis)とよび,ストレス性疾患の病態を理解するためのモデルとなっている.(著者抄録)

特集 慢性疼痛 心理的な痛みの機序

梅田 聡

BRAIN and NERVE （株式会社医学書院）  75 （ 3 ） 243 - 252 2023年03月

ISSN  18816096

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This article first reviews some methods for measuring psychological pain, as a subjective sensation, and outlines its neural mechanisms. Particularly, the involvement of the neural basis of the salience network, which consists of the insula and cingulate cortex, is described focusing on its relation to interoception. Next, we focus on the disease concept of psychological pain as a pathological condition, review some studies on somatic symptom disorder and related disorders, and discuss some possible methods of pain and future research directions.

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【慢性疼痛】心理的な痛みの機序

梅田 聡

BRAIN and NERVE: 神経研究の進歩 （(株)医学書院）  75 （ 3 ） 0243 - 0252 2023年03月

ISSN  1881-6096

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＜文献概要＞本論では,まず主観的感覚である心理的痛みを測定する方法について述べ,その神経メカニズムについて概説する。特に,島皮質および帯状皮質から構成されるセイリエンスネットワークを中心とした神経基盤の関与について,内受容感覚との関連性に着目しながら述べる。次に,心理的痛みを病態として捉える疾患概念に焦点を当て,身体症状症などに関する研究成果を概観し,心理的痛みの緩和および今後の研究の方向性について考察する。

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

Amano M., Katayama N., Umeda S., Terasawa Y., Tabuchi H., Kikuchi T., Abe T., Mimura M., Nakagawa A.

Frontiers in Psychiatry 14   997154 - 997154 2023年01月

査読有り,  ISSN  1664-0640

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Background: Pessimistic thinking about the future is one of the cardinal symptoms of major depression. Few studies have assessed changes in pessimistic thinking after undergoing cognitive behavioral therapy (CBT). A randomized clinical trial (RCT) was conducted with patients diagnosed with major depressive disorder (MDD) to determine whether receiving a course of CBT affects pessimistic future thinking using a future thinking task. Methods: Thirty-one patients with MDD were randomly assigned to either CBT (n = 16) or a talking control (TC) (n = 15) for a 16-week intervention. The main outcomes were the change in response time (RT) and the ratio of the responses for positive valence, measured by the future thinking task. Secondary outcomes included the GRID-Hamilton Depression Rating Scale, the Beck Depression Inventory-Second Edition (BDI-II), the Dysfunctional Attitude Scale (DAS), and the word fluency test (WFT). Results: Regarding the main outcomes, the CBT group showed reduced RT for the positive valence (within-group Cohen’s d = 0.7, p = 0.012) and negative valence (within-group Cohen’s d = 0.6, p = 0.03) in the distant future condition. The ratio of positive valence responses in both groups for all temporal conditions except for the distant past condition increased within group (distant future: CBT: Cohen’s d = 0.5, p = 0.04; TC: Cohen’s d = 0.8, p = 0.008; near future: CBT: Cohen’s d = 1.0, p < 0.001; TC: Cohen’s d = 1.1, p = 0.001; near past: CBT: Cohen’s d = 0.8, p = 0.005; TC: Cohen’s d = 1.0, p = 0.002). As for secondary outcomes, the CBT group showed greater improvement than the TC group regarding the need for social approval as measured by the DAS (p = 0.012). Conclusion: Patients with MDD who received CBT showed a reduced RT for the positive and negative valence in the distant future condition. RT in the future thinking task for depressed patients may be a potential objective measure for the CBT treatment process. Because the present RCT is positioned as a pilot RCT, a confirmatory trial with a larger number of patients is warranted to elucidate the CBT treatment process that influences future thinking. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000021028, identifier UMIN000018155.

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Effects of matured hop bitter acids on heart rate variability and cognitive performance: A randomized placebo-controlled crossover trial

Kanatome A., Takara T., Umeda S., Ano Y.

Journal of Functional Foods 100 2023年01月

査読有り,  ISSN  17564646

　概要を見る

Matured hop bitter acids (MHBA), produced by aging the hops used to make beer, activate the vagus nerve via bitter taste receptors and improve depression and cognitive function in mice. However, researchers have not investigated their effects on human autonomic nerves. This crossover study aimed to investigate the association between MHBA and the vagus nerve. We randomly assigned 34 participants (age: 30–64 years) into two sequences (n = 17 each). They performed cognitive tasks before and after a single supplementation with placebo or MHBA. We monitored the autonomic nerve activity using heart rate variability. Compared with placebo, MHBA supplementation significantly increased the high frequency (HF) and total power during cognitive tasks (322.2 ms² [95 % confidence interval (CI), 28.0, 616.4]; p = 0.033 and 630.6 ms² [95 % CI, 87.0, 1174.2]; p = 0.025, respectively). In summary, MHBA supplementation modulates the HF of parasympathetic nerve activity in healthy adults.

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AI社会への「自己」の適応

上原 泉, 杉浦 元亮, 小林 哲生, 梅田 聡

日本心理学会大会発表論文集 （公益社団法人 日本心理学会）  87 （ 0 ） SS-037 - SS-037 2023年

　概要を見る

<p>近年，AIや仮想技術の進展が著しい。それらの技術により，身体拡張や知覚拡張，メタバースでの交流や様々なVR体験が可能になってきている。ここにきての，ChatGPTの出現で，物事の進み方や社会のあり方が大きく変わる可能性が指摘されている。便利になることへの期待もある一方で，ヒトにとって代わりAIができることが増えていくことへの不安も大きくなっている。既に，インターネットの普及で物事の進み方が加速化し，「自己」が振り回されている感は否めず，急速なこれらの技術の進展により，「自己」が機能不全に陥る可能性が懸念される。人知を超える速さで進展していく社会における「自己」のあり方は，新たな学術的枠組みから，追究していく必要があるのではないかと考え，研究を始めている。本シンポジウムでは，この新たな「自己」研究の可能性を広く議論するため企画した。話題提供では，小林氏が「自己の発達」，梅田氏が「自己の歪み」，杉浦氏が「自己の3側面と“新自己力”」をテーマにそれぞれの知見を紹介する。上原より，新たな「自己」に関する発達理論形成の可能性とその視点からのコメントを行い，その後，全体討論としたい。</p>

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Eye-tracking paradigms for the assessment of mild cognitive impairment: a systematic review

Wolf A., Tripanpitak K., Umeda S., Otake-Matsuura M.

Frontiers in Psychology 14   1197567 - 1197567 2023年

査読有り,  ISSN  1664-1078

　概要を見る

Mild cognitive impairment (MCI), representing the ‘transitional zone’ between normal cognition and dementia, has become a novel topic in clinical research. Although early detection is crucial, it remains logistically challenging at the same time. While traditional pen-and-paper tests require in-depth training to ensure standardized administration and accurate interpretation of findings, significant technological advancements are leading to the development of procedures for the early detection of Alzheimer’s disease (AD) and facilitating the diagnostic process. Some of the diagnostic protocols, however, show significant limitations that hamper their widespread adoption. Concerns about the social and economic implications of the increasing incidence of AD underline the need for reliable, non-invasive, cost-effective, and timely cognitive scoring methodologies. For instance, modern clinical studies report significant oculomotor impairments among patients with MCI, who perform poorly in visual paired-comparison tasks by ascribing less attentional resources to novel stimuli. To accelerate the Global Action Plan on the Public Health Response to Dementia 2017–2025, this work provides an overview of research on saccadic and exploratory eye-movement deficits among older adults with MCI. The review protocol was drafted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic databases were systematically searched to identify peer-reviewed articles published between 2017 and 2022 that examined visual processing in older adults with MCI and reported gaze parameters as potential biomarkers. Moreover, following the contemporary trend for remote healthcare technologies, we reviewed studies that implemented non-commercial eye-tracking instrumentation in order to detect information processing impairments among the MCI population. Based on the gathered literature, eye-tracking-based paradigms may ameliorate the screening limitations of traditional cognitive assessments and contribute to early AD detection. However, in order to translate the findings pertaining to abnormal gaze behavior into clinical applications, it is imperative to conduct longitudinal investigations in both laboratory-based and ecologically valid settings.

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神経疾患における自律神経障害と情動・認知障害

梅田 聡

脳神経内科 99   27 - 33 2023年

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未来に向けられた認知の神経メカニズム

梅田 聡

Clinical Neuroscience 41   1090 - 1093 2023年

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感情研究における顔面皮膚血流の有用性と臨床応用

石川 直樹, 梅田 聡

Annual Review神経2023 ー 2023年

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