Presentations -

Lipase-mediated kinetic resolution of 1,3-benzodioxols toward development of new chiral derivatizing reagents

N. Natori, M. Shoji, T. Sugai, K. Hanaya

Biotrans 2015 (Vienna (Austria)) , 

2015.07

, 

Poster presentation

Synthesis of artepillin C, based on lipase-catalyzed regioselective deacetylation

K. Yashiro, Hanaya, M. Shoji, T. Sugai

Biotrans 2015 (Vienna (Austria)) , 

2015.07

, 

Poster presentation

Biocatalyltic approach to stereochemidally enriched forms of 2-hydroxycyclohexanecarboxylate esters

R. Tsunekawa, Hanaya, M. Shoji, T. Sugai

Biotrans 2015 (Vienna (Austria)) , 

2015.07

, 

Poster presentation

Exploration of whole-cell yeast biocatalysts towards natural product synthesis

R. Tsunekawa, B. Fujitani, K. Hamazume, A. Miki, A. Narita, K. Yashiro, S. Yoshioka, K. Yuuki, K. Hanaya, M. Shoji, T. Sugai

Active Enzyme Molecule 2014 (Toyama (Japan)) , 

2014.12

, 

Poster presentation

Synthesis of both enantiomers of MNB carboxylic acid by utilizing lipase-catalyzed kinetic resolution

N. Natori, M. Shoji, T. Sugai, K. Hanaya

Active Enzyme Molecule 2014 (Toyama (Japan)) , 

2014.12

, 

Poster presentation

Synthetic approaches to rare flavonoids based on regioselective transformation

T. Sugai, Y. Matuuchi, R. Kobayashi, T. Itou, K. Hanaya, M. Shoji, N. Hada, F. Kiuchi

27th International Conference on Polyphenols and 8th Tannin Conference (東京都（京王プラザホテル）) , 

2014.09

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Poster presentation

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DHMEQの酵素－化学合成をプロセススケールから検討した。

Scalable Chemo-enzymatic Preparation for Both Enantiomers of Dehydroxymethylepoxyquinomicin (DHMEQ)

Sugai T., Higashi T., Shoji M., Umezawa K

AIMECS 11: The 8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science (東京都（京王プラザホテル）) , 

2011.11

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Poster presentation

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DHMEQの酵素－化学合成をプロセススケールから検討した。

Recognition of Remote Chirality in Lipase-catalyzed Acylation - Application to the Resolution of a Sterically Hindered Alcohol

r. Kobayashi, H. Huang, T. Higashi, M. Shoji, T. Sugai

10th International Symposium on Biocatalysis and Biotransformations (Giardini Naxos, Italy) , 

2011.10

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Poster presentation

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立体障害の大きい芳香族第二級アルコールの光学分割の新手法を開拓、ステリコールの分割に成功した。

Enantiomerically enriched forms of aromatic halohydrins by whole-cell biocatalys-mediated asymmetric reduction

S. Taketomi, M. Asano, T. Higashi, M. Shoji, T. Sugai

10th International Symposium on Biocatalysis and Biotransformations (Giardini Naxos, Italy) , 

2011.10

, 

Poster presentation

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ハロアセトフェノン類の不斉還元を基盤とする、有用物質合成について発表した。

Chemo-enzymatic approaches towares both enantiomer of dehydroxymethylepoxyquinomicin (DHMEQ)

R. Kobayashi, Y. Niitsu, M. Hamada, C. Hiraoka, T. Higashi, M. Shoji, K. Umezawa, T. Sugai

The Second Symposium on Process Chemistry [ISPC 11] (京都府（京都国際会議場）) , 

2011.08

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Poster presentation

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DHMEQの酵素－化学複合合成について発表した。

Recognition of remote chiral centers in the course of lipasecatalyzed resolution and its application to both enantiomers of TBMB acid

T. Higashi, K. Ninomiya, M. Shoji, T. Sugai

The International Chemical Congress of Pacific Basin Societies (Honolulu, Hawaii) , 

2010.12

, 

Oral presentation (general)

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Candida antarctica lipaseおよびBurkholderia cepacia lipaseが持つ遠隔不斉中心の立体化学認識能を明らかにし、TBMBカルボン酸両鏡像体合成へ応用した。

Study on hydrolase-catalyzed preparation of 2,2-disubstituted cyanoacetates, and malonates

T. Kurihara, T. Higashi, M. Shoji, T. Sugai

The International Chemical Congress of Pacific Basin Societies (Honolulu, Hawaii) , 

2010.12

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Poster presentation

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ラニレスタットの活性本体鏡像体の合成を目指し、表題化合物の酵素的変換を検討した。

Approaches to new chiral building blocks by means of Bacillus subtilis epoxide hydrolase

K. Shimizu, M. Sakamoto, T. Higashi, M. Shoji, T. Sugai

The International Chemical Congress of Pacific Basin Societies (Honolulu, Hawaii) , 

2010.12

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Poster presentation

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枯草菌エポキシドヒドロラーゼの基質特異性を明らかにし、有用物質の光学分割に応用した。

Kinetic resolution of carbasugars by means of hydrolase-catalyzed reactions and the application to the synthesis of (3S,4S,5R)-(-)-epishikimic acid

M. Hamada, Y. Inami, T. Higashi, S. Ogawa, K. Unezawa, T. Sugai

9th International Symposium on Biocatalysis and Biotransformations (Bern (Switzerland)) , 

2009.07

, 

Poster presentation

Study on substrate specificity of Bacillus subtilis epoxide hydrolase

M. Sakamoto, M. Hamada, A. Fujino, T. Higashi, T. Sugai

9th International Symposium on Biocatalysis and Biotransformations (Bern (Switzerland)) , 

2009.07

, 

Poster presentation

Enzymes exhibiting unique stereochemical recognition of remote chiral center in the substrates with trifluoromethyl group

K.Uemura, C. Abe, T. Higashi, T. Sugai

9th International Symposium on Biocatalysis and Biotransformations (Bern (Switzerland)) , 

2009.07

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Poster presentation

Chemo-enzymatic approach towards new sialic acid derivatives

J. Calveras, Y. Ueda, Y. Nagai, H. Nagano, I. Sultana, T. Higashi, T. Sugai

9th International Symposium on Biocatalysis and Biotransformations (Bern (Switzerland)) , 

2009.07

, 

Poster presentation

Enzyme-catalyzed enantiomeric resolution of tamiflu intermediates

Manabu Hamada, Seiichiro Ogawa, Toshinori Higashi, Keiko Inami, Kazuo Umezawa, Takeshi Sugai, Kaoru Nakamura

The First Symposium on Process Chemistry [ISPC 08] (京都府（京都国際会議場）) , 

2008.07

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Poster presentation

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フランとアクリル酸のDiels-Alder反応および数工程で得られるラセミ体三環性エポキシエステルを豚肝臓エステラーゼを用いて酵素分割、有機合成的手法によりタミフル中間体へと変換した。

The Synthesis of (R)-Bicalutamide based on B. subtilis Epoxide Hydrolase-catalyzed Kinetic Resolution

A. Fujino, M. Asano, H. Yamaguchi, M. Ikunaka, T. Sugai

8th International Symposium on Biocatalysis and Biotransformations (Oviedo (Spain)) , 

2007.07

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Poster presentation

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B. subtilis由来の組み換えエポキシドヒドロラーゼを用いたラセミ体エポキシドの加水分解を鍵反応に、抗男性ホルモン剤であるビカルタミドの活性本体を効率よく合成する方法を開発した。

Development of Whole-cell Biocatalysts Which Reduce Sterically Hindered Ketones and its Application

C. Hiraoka, M. Matsuda, Y. Suzuki, S. Fujieda, K. Fuhshuku, T. Sugai

8th International Symposium on Biocatalysis and Biotransformations (Oviedo (Spain)) , 

2007.07

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Poster presentation

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立体障害の大きいカルボニル化合物を還元できる新しい還元酵素を有する微生物（酵母）をスクリーニング、基質特異性を明らかにすると同時に、天然物合成に展開した。