Papers - Sato, Yasunori

Utility of the EULAR Sjögren syndrome disease activity index in Japanese children: a retrospective multicenter cohort study.

Iwata N, Tomiita M, Kobayashi I, Inoue Y, Nonaka Y, Okamoto N, Umebayashi H, Hara R, Ito Y, Sato Y, Mori M

Pediatric rheumatology online journal 18 ( 1 ) 73 2020.09

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Development of a High-Efficacy Reprogramming Method for Generating Human Induced Pluripotent Stem (iPS) Cells from Pathologic and Senescent Somatic Cells.

Tanaka N, Kato H, Tsuda H, Sato Y, Muramatsu T, Iguchi A, Nakajima H, Yoshitake A, Senbonmatsu T

International journal of molecular sciences (International Journal of Molecular Sciences)  21 ( 18 ) 1 - 16 2020.09

ISSN  16616596

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Induced pluripotent stem (iPS) cells are a type of artificial pluripotent stem cell induced by the epigenetic silencing of somatic cells by the Yamanaka factors. Advances in iPS cell reprogramming technology will allow aging or damaged cells to be replaced by a patient’s own rejuvenated cells. However, tissue that is senescent or pathologic has a relatively low reprogramming efficiency as compared with juvenile or robust tissue, resulting in incomplete reprogramming; iPS cells generated from such tissue types do not have sufficient differentiation ability and are therefore difficult to apply clinically. Here, we develop a new reprogramming method and examine it using myofibroblasts, which are pathologic somatic cells, from patient skin tissue and from each of the four heart chambers of a recipient heart in heart transplant surgery. By adjusting the type and amount of vectors containing transcriptional factors for iPS cell reprogramming, as well as adjusting the transfection load and culture medium, the efficiency of iPS cell induction from aged patient skin-derived fibroblasts was increased, and we successfully induced iPS cells from myocardial fibroblasts isolated from the pathologic heart of a heart transplant recipient.

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The Association of In-Hospital Transcatheter Aortic Valve Replacement Availability on Outcomes of Surgical Aortic Valve Replacement in Elderly Patients.

Tabata M, Kumamaru H, Ono A, Miyata H, Sato Y, Motomura N

Circulation journal : official journal of the Japanese Circulation Society (一般社団法人 日本循環器学会)  84 ( 9 ) 1599 - 1604 2020.08

ISSN  1346-9843

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<p><b><i>Background:</i></b>Transcatheter aortic valve replacement (TAVR) has been performed more and more frequently in elderly patients with aortic stenosis. We investigated the association of in-hospital availability of TAVR on outcomes of surgical aortic valve replacement (SAVR) in the era of TAVR.</p><p><b><i>Methods and Results:</i></b>We utilized data from the Japan Adult Cardiovascular Surgery Database. Between October 2013 and December 2016, 9,330 patients aged ≥80 years underwent isolated SAVR or SAVR with coronary artery bypass grafting in 557 centers in Japan. We assessed the associations of in-hospital TAVR availability with operative mortality and composite complications adjusting for each patient's characteristics, JapanSCORE predicted the risk scores, and hospital volumes of SAVR using generalized estimation equation methods. Observed operative mortality rates were 3.4% in all centers, 2.0% in TAVR centers and 4.0% in non-TAVR centers. The multivariable analyses showed that TAVR centers had statistically significantly lower operative mortality compared with non-TAVR centers among all patients (odds ratio 0.60, 95% confidence interval 0.41–0.89, P=0.01) and among intermediate/high-risk patients (odds ratio 0.52, 95% confidence interval 0.32–0.85, P<0.01) but not among low-risk patients (odds ratio 0.82, 95% confidence interval 0.44–1.51, P=0.52).</p><p><b><i>Conclusions:</i></b>In-hospital TAVR availability was associated with better outcomes of SAVR among elderly patients. This association was statistically significant among intermediate/high-risk patients but not significant among low-risk patients.</p>

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Stereotactic radiosurgery for brain metastases: A retrospective cohort study comparing treatment results between two lung cancer patient age groups, 75 years or older vs 65-74 years.

Yamamoto M, Serizawa T, Sato Y, Higuchi Y, Kasuya H, Barfod BE

Lung cancer (Amsterdam, Netherlands) (Lung Cancer)  149   103 - 112 2020.08

ISSN  0169-5002

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© 2020 Elsevier B.V. Background: There is little information on stereotactic radiosurgery (SRS) results for brain metastases (BMs) in lung cancer patients ≥75 years of age. We aimed to reappraise whether SRS results for patients ≥75 (very elderly) differ from those of patients with 65−74 years old (elderly). Methods: This IRB-approved retrospective cohort study was based on our prospectively-accumulated database including 7351 consecutive patients undergoing gamma knife (GK) SRS performed for BMs by two highly experienced neurosurgeons during the 1998–2018 period. We selected a total of 2915 elderly patients (age ≥65 years, 39.7 % of the 7351) with lung cancers (902 females, 2013 males, median age; 72 [maximum; 96] years, 2441 NSCLCs, 474 SCLCs) for this study. Results: Post-SRS median survival times (MSTs, months) differed significantly between the two lung cancer types, NSCLC (9.0) and SCLC (7.2, p < 0.0001). In NSCLC patients, post-SRS MSTs were significantly shorter in the very elderly (9.7) than those in the elderly (7.8) group (p < 0.0001). However, in SCLC patients, there were no significant MST differences (7.3 vs 6.9, p = 0.52) between the two age groups. In both NSCLC and SCLC patients, neither crude nor cumulative incidences of secondary endpoints in the very elderly group, i.e., neurological death, neurological deterioration, local recurrence, repeat SRS, salvage whole brain radiotherapy and SRS-related complications, were shown to be unfavorable to those in the elderly group. Conclusions: Our results suggest that carefully-selected patients ≥75 years of age are not poor candidates for SRS as compared to those 65−74 years old.

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Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial.

Kawamatsu S, Jin R, Araki S, Yoshioka H, Sato H, Sato Y, Hisaka A

Journal of clinical medicine 9 ( 8 )  2020.08

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Evaluation of Nuclear Cataract with Smartphone-Attachable Slit-Lamp Device.

Yazu H, Shimizu E, Okuyama S, Katahira T, Aketa N, Yokoiwa R, Sato Y, Ogawa Y, Fujishima H

Diagnostics (Basel, Switzerland) 10 ( 8 )  2020.08

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Impact of breast cancer subtype on clinical outcomes after Gamma Knife radiosurgery for brain metastases from breast cancer: a multi-institutional retrospective study (JLGK1702).

Aoyagi K, Higuchi Y, Matsunaga S, Serizawa T, Yomo S, Aiyama H, Nagano O, Kondoh T, Kenai H, Shuto T, Kawagishi J, Jokura H, Sato S, Nakazaki K, Nakaya K, Hasegawa T, Kawashima M, Kawai H, Yamanaka K, Nagatomo Y, Yamamoto M, Sato Y, Aoyagi T, Matsutani T, Iwadate Y

Breast cancer research and treatment (Breast Cancer Research and Treatment)   2020.08

ISSN  0167-6806

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© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Introduction: Brain metastasis (BM) is one of the most important issues in the management of breast cancer (BC), since BMs are associated with neurological deficits. However, the importance of BC subtypes remains unclear for BM treated with Gamma Knife radiosurgery (GKS). Thus, we conducted a multicenter retrospective study to compare clinical outcomes based on BC subtypes, with the aim of developing an optimal treatment strategy. Methods: We studied 439 patients with breast cancer and 1–10 BM from 16 GKS facilities in Japan. Overall survival (OS) was analyzed by the Kaplan–Meier method, and cumulative incidences of systemic death (SD), neurologic death (ND), and tumor progression were estimated by competing risk analysis. Results: OS differed among subtypes. The median OS time (months) after GKS was 10.4 in triple-negative (TN), 13.7 in Luminal, 31.4 in HER2, and 35.8 in Luminal-HER2 subtype BC (p < 0.0001). On multivariate analysis, poor control of the primary disease (hazard ratio [HR] = 1.84, p < 0.0001), active extracranial disease (HR = 2.76, p < 0.0001), neurological symptoms (HR 1.44, p = 0.01), and HER2 negativity (HR = 2.66, p < 0.0001) were significantly associated with worse OS. HER2 positivity was an independent risk factor for local recurrence (p = 0.03) but associated with lower rates of ND (p = 0.03). TN histology was associated with higher rates of distant brain failure (p = 0.03). Conclusions: HER2 positivity is related to the longer OS after SRS; however, we should pay attention to preventing recurrence in Luminal-HER2 patients. Also, TN patients require meticulous follow-up observation to detect distant metastases and/or LMD.

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Clinical risk model for predicting 1-year mortality after transcatheter aortic valve replacement.

Yamamoto M, Otsuka T, Shimura T, Yamaguchi R, Adachi Y, Kagase A, Tokuda T, Yashima F, Watanabe Y, Tada N, Naganuma T, Araki M, Yamanaka F, Mizutani K, Tabata M, Watanabe S, Sato Y, Ueno H, Takagi K, Higashimori A, Shirai S, Hayashida K

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions  2020.07

ISSN  1522-1946

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Tofogliflozin does not delay progression of carotid atherosclerosis in patients with type 2 diabetes: a prospective, randomized, open-label, parallel-group comparative study.

Katakami N, Mita T, Yoshii H, Shiraiwa T, Yasuda T, Okada Y, Torimoto K, Umayahara Y, Kaneto H, Osonoi T, Yamamoto T, Kuribayashi N, Maeda K, Yokoyama H, Kosugi K, Ohtoshi K, Hayashi I, Sumitani S, Tsugawa M, Ryomoto K, Taki H, Nakamura T, Kawashima S, Sato Y, Watada H, Shimomura I, UTOPIA study investigators.

Cardiovascular diabetology 19 ( 1 ) 110 2020.07

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<i>Staphylococcus</i> Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development.

Nakamura Y, Takahashi H, Takaya A, Inoue Y, Katayama Y, Kusuya Y, Shoji T, Takada S, Nakagawa S, Oguma R, Saito N, Ozawa N, Nakano T, Yamaide F, Dissanayake E, Suzuki S, Villaruz A, Varadarajan S, Matsumoto M, Kobayashi T, Kono M, Sato Y, Akiyama M, Otto M, Matsue H, Núñez G, Shimojo N

Science translational medicine 12 ( 551 )  2020.07

ISSN  1946-6234

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Inter-agency collaboration factors affecting multidisciplinary workers' ability to identify child maltreatment.

Okato A, Hashimoto T, Tanaka M, Saito N, Endo M, Okayama J, Ichihara A, Eshima S, Handa S, Senda M, Sato Y, Watanabe H, Nakazato M, Iyo M

BMC research notes 13 ( 1 ) 323 2020.07

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Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Sub-analysis of a prospective, randomized, controlled study (PRIME-V study).

Koshizaka M, Ishikawa K, Ryoichi I, Maezawa Y, Sakamoto K, Uchida D, Nakamura S, Yamaga M, Yokoh H, Kobayashi A, Onishi S, Kobayashi K, Ogino J, Hashimoto N, Tokuyama H, Shimada F, Ohara E, Ishikawa T, Shoji M, Ide S, Ide K, Baba Y, Hattori A, Kitamoto T, Horikoshi T, Shimofusa R, Takahashi S, Nagashima K, Sato Y, Takemoto M, Newby LK, Yokote K, PRIME-V study group.

Journal of diabetes investigation  2020.07

ISSN  2040-1116

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Genetic risks of schizophrenia identified in a matched case-control study.

Oishi K, Niitsu T, Kanahara N, Sato Y, Iwayama Y, Toyota T, Hashimoto T, Sasaki T, Takase M, Shiina A, Yoshikawa T, Iyo M

European archives of psychiatry and clinical neuroscience  2020.07

ISSN  0940-1334

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Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease.

Asakura T, Kimizuka Y, Nishimura T, Suzuki S, Namkoong H, Masugi Y, Sato Y, Ishii M, Hasegawa N

Respirology (Carlton, Vic.)  2020.06

ISSN  1323-7799

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Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial.

Obara H, Takeuchi M, Kawakubo H, Shinoda M, Okabayashi K, Hayashi K, Sekimoto Y, Maeda Y, Kondo T, Sato Y, Kitagawa Y

The Lancet. Infectious diseases  2020.06

ISSN  1473-3099

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Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study.

Rusthoven CG, Yamamoto M, Bernhardt D, Smith DE, Gao D, Serizawa T, Yomo S, Aiyama H, Higuchi Y, Shuto T, Akabane A, Sato Y, Niranjan A, Faramand AM, Lunsford LD, McInerney J, Tuanquin LC, Zacharia BE, Chiang V, Singh C, Yu JB, Braunstein S, Mathieu D, Touchette CJ, Lee CC, Yang HC, Aizer AA, Cagney DN, Chan MD, Kondziolka D, Bernstein K, Silverman JS, Grills IS, Siddiqui ZA, Yuan JC, Sheehan JP, Cordeiro D, Nosaki K, Seto T, Deibert CP, Verma V, Day S, Halasz LM, Warnick RE, Trifiletti DM, Palmer JD, Attia A, Li B, Cifarelli CP, Brown PD, Vargo JA, Combs S, Kessel KA, Rieken S, Patel S, Guckenberger M, Andratschke N, Kavanagh BD, Robin TP

JAMA oncology  2020.06

ISSN  2374-2437

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A comparative evaluation of cataract classification with the conventional slit-lamp examination and a portable medical device "Smart Eye Camera"

Yazu Hiroyuki, Okuyama Sho, Katahira Takuya, Shimizu Eisuke, Aketa Naohiko, Sato Yasunori, Ogawa Yoko, Fujishima Hiroshi

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 61 ( 7 )  2020.06

ISSN  0146-0404

A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4.

Fujioka M, Akiyama T, Hosoya M, Kikuchi K, Fujiki Y, Saito Y, Yoshihama K, Ozawa H, Tsukada K, Nishio SY, Usami SI, Matsunaga T, Hasegawa T, Sato Y, Ogawa K

Medicine 99 ( 19 ) e19763 2020.05

ISSN  0025-7974

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The effects of health education on health science teachers' intention to recommend adolescent HPV vaccine for female students in Japan.

Ishiwada N, Suzuki C, Hasebe S, Tsuchiya A, Takeuchi N, Hishiki H, Sato Y, Sugita K

Human vaccines & immunotherapeutics    1 - 6 2020.03

ISSN  2164-5515

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Midterm Results of a Japanese Prospective Multicenter Registry of Heparin-Bonded Expanded Polytetrafluoroethylene Grafts for Above-the-Knee Femoropopliteal Bypass.

Shibutani S, Obara H, Matsubara K, Toya N, Isogai N, Ogino H, Watada S, Asami A, Kudo T, Kanaoka Y, Fujimura N, Harada H, Uchiyama H, Sato Y, Ohki T, Japanese Bypass Registry Group, Tokyo, Japan.

Circulation journal : official journal of the Japanese Circulation Society  2020.02

ISSN  1346-9843

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