Papers - Sato, Yasunori

Contact-free assessments of respiratory rate and volume with load cells under the bed legs in ventilated patients: A prospective exploratory observational study.

Azusa Inada, Shin Inaba, Yosuke Matsumura, Takuya Sugiyama, Noriyuki Hanaoka, Naohiko Fujiyoshi, Natsuko Nozaki-Taguchi, Yasunori Sato, Shiroh Isono

Journal of applied physiology (Bethesda, Md. : 1985) 134 ( 6 ) 1341 - 1348 2023.06

ISSN  8750-7587

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Development of reliable non-contact unrestrained respiratory monitoring is capable of augmenting the safety of hospitalized patients in the recovery phase. We previously discovered respiratory-related centroid shifts along the long axis of the bed with load cells under the bed legs (bed sensor system: BSS). This prospective exploratory observational study examined whether non-contact measurements of respiratory-related tidal centroid shift amplitude (TA-BSS: primary variable) and respiratory rate (RR-BSS: secondary variable) were correlated with tidal volume (TV-PN) and respiratory rate (RR-PN), respectively measured by pneumotachograph in 14 ICU patients under mechanical ventilation. Among the 10-minute average data automatically obtained for a 48-hour period, 14 data were randomly selected from each patient. Successfully and evenly selected 196 data points for each variable were used for the purpose of this study. A good agreement between TA-BSS and TV-PN (Pearson's r = 0.669) and an excellent agreement between RR-BSS and RR-PN (r = 0.982) were observed. Estimated minute ventilatory volume as 3.86*TA-BSS*RR-BSS (MV-BSS) was found to be in very good agreement with true minute volume (MV-PN) (r = 0.836). Although Bland-Altman analysis evidenced accuracy of MV-BSS by a small insignificant fixed bias (-0.02 liter/min), a significant proportional bias of MV-BSS (r = -0.664) appeared to produce larger precision (1.9 liter/min) of MV-BSS. We conclude that contact-free unconstraint respiratory monitoring with load cells under the bed legs may serve as a new clinical monitoring system, when improved.

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Screening practices of cancer survivors and individuals whose family or friends had a cancer diagnoses-a nationally representative cross-sectional survey in Japan (INFORM Study 2020).

Miki Akiyama, Noriyuki Ishida, Hiroyasu Takahashi, Miyako Takahashi, Aki Otsuki, Yasunori Sato, Junko Saito, Akiko Yaguchi-Saito, Maiko Fujimori, Yuki Kaji, Taichi Shimazu

Journal of cancer survivorship : research and practice 17 ( 3 ) 663 - 676 2023.06

ISSN  1932-2259

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PURPOSE: We examined cancer screening practices and related beliefs in cancer survivors and individuals with family or close friends with a cancer diagnosis compared to individuals without the above cancer history for 5 population-based (gastric, colorectal, lung, breast, cervical) and 1 opportunistic (prostate) cancer screenings using nationally representative cross-sectional survey in Japan. METHODS: We analyzed 3269 data from 3605 respondents (response rate, 37.1%) and compared the screening beliefs and practices of cancer survivors (n = 391), individuals with family members (n = 1674), and close friends with a cancer diagnosis (n = 685) to those without any cancer history (n = 519). RESULTS: Being a cancer survivor was associated with screening for gastric (OR, 1.75; 95% CI, 1.04-2.95), colorectal (OR, 1.56; 95% CI, 1.03-2.36), and lung cancer (OR, 1.71; 95% CI, 1.10-2.66) but not breast, cervical cancer or PSA test. Having a family cancer diagnosis was associated with colorectal and lung cancer screening. Having friends with a cancer diagnosis was associated with PSA test. Cancer survivors and family members perceived themselves as being more susceptible and worried about getting cancer than individuals without any cancer history. Cancer survivors strongly believed screening can detect cancer and were more likely to undergo screening. Subgroup analysis indicated an interrelation between gastric and colorectal cancer screening among survivors. CONCLUSIONS: A cancer diagnosis in oneself or family or friend influences an individual's health-related belief and risk perception, which can increase the likelihood of cancer screening. IMPLICATIONS FOR CANCER SURVIVORS: Targeted and tailored communication strategies can increase awareness of cancer screening.

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Comparison of First-Line Radiosurgery for Small-Cell and Non-Small Cell Lung Cancer Brain Metastases (Cross-FIRE).

Chad G Rusthoven, Alyse W Staley, Dexiang Gao, Shoji Yomo, Denise Bernhardt, Narine Wandrey, Rami El Shafie, Anna Kraemer, Oscar Padilla, Veronica Chiang, Andrew M Faramand, Joshua D Palmer, Brad E Zacharia, Rodney E Wegner, Jona A Hattangadi-Gluth, Antonin Levy, Kenneth Bernstein, David Mathieu, Daniel N Cagney, Michael D Chan, Inga S Grills, Steve Braunstein, Cheng-Chia Lee, Jason P Sheehan, Christien Kluwe, Samir Patel, Lia M Halasz, Nicolaus Andratschke, Christopher P Deibert, Vivek Verma, Daniel M Trifiletti, Christopher P Cifarelli, Jürgen Debus, Stephanie E Combs, Yasunori Sato, Yoshinori Higuchi, Kyoko Aoyagi, Paul D Brown, Vida Alami, Ajay Niranjan, L Dade Lunsford, Douglas Kondziolka, D Ross Camidge, Brian D Kavanagh, Tyler P Robin, Toru Serizawa, Masaaki Yamamoto

Journal of the National Cancer Institute  2023.05

ISSN  0027-8874

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INTRODUCTION: Historical reservations regarding radiosurgery (SRS) for small-cell-lung-cancer (SCLC) brain metastases (BrM) include concerns for short-interval/diffuse CNS-progression, poor prognoses, and increased neurological mortality specific to SCLC histology. We compared SRS outcomes for SCLC and non-small-cell-lung-cancer (NSCLC) where SRS is well established. METHODS: Multicenter first-line SRS outcomes for SCLC and NSCLC from 2000-2022 were retrospectively collected (N=892-SCLC/N=4,785-NSCLC). Data from the prospective JLGK0901 SRS trial were analyzed as a comparison cohort (N=98-SCLC/N=794-NSCLC). OS and CNS-progression were analyzed using Cox-Proportional-Hazard and Fine-Gray models, respectively, with multivariable (MV) adjustment (including age/sex/performance-status/year/extracranial disease/BrM-number/BrM-volume). Mutation-stratified analyses were performed in propensity score-matched (PSM) retrospective cohorts of EGFR/ALK-positive-NSCLC, mutation-negative-NSCLC, and SCLC. RESULTS: OS was superior with NSCLC over SCLC in the retrospective dataset (median-OS, 10.5 vs 8.6 months, MV-p<0.001) and JLGK0901. Hazard estimates for first CNS-progression favoring NSCLC were similar in both datasets but reached significance in the retrospective dataset only (MV-HR:0.82 [95%-CI:0.73-0.92], p=0.001). In the PSM cohorts, there were continued OS advantages for NSCLC (median-OS, 23.7 [EGFR/ALK-positive-NSCLC] vs 13.6 [mutation-negative-NSCLC] vs 10.4 months [SCLC], pairwise-p-values<0.001), but no significant differences in CNS-progression. Neurological mortality and number of lesions at CNS-progression were similar for NSCLC and SCLC patients. Leptomeningeal-progression was increased in NSCLC patients in the retrospective dataset only (MV-HR:1.61 [95%-CI:1.14-2.26], p=0.007). CONCLUSION: After SRS, SCLC was associated with shorter OS compared to NSCLC. CNS progression occurred earlier in SCLC overall but was similar in patients matched on baseline characteristics. Neurological mortality, lesions at CNS-progression, and leptomeningeal-progression were comparable. These findings may better inform clinical decision-making for SCLC patients.

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Thrombus formation at the stump of the pulmonary vein after lobectomy: a prospective multi-institutional study.

Takayoshi Yamamoto, Hidemi Suzuki, Yuichi Sakairi, Takekazu Iwata, Toshihiko Iizasa, Tetsuzo Tagawa, Shigetoshi Yoshida, Ryo Takemura, Yasunori Sato, Ichiro Yoshino

Surgery today 16 ( 3 ) S262 - S262 2023.05

ISSN  0941-1291

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PURPOSE: Recent reports suggest that postoperative cerebral infarction following lung cancer surgery is caused by thrombus formation at the stump of the pulmonary vein and that the risk is highest after left upper lobectomy (LUL). Thrombosis at the stump of the pulmonary vein and the incidence of cerebral infarction was investigated prospectively in patients who underwent lobectomy for lung cancer. METHODS: Lung cancer patients undergoing planned pulmonary lobectomy were enrolled. The endpoint was to confirm if there is a higher incidence of thrombus formation (primary) and a higher incidence of cerebral infarction (secondary) in patients undergoing LUL. We planned to accrue 600 patients. An interim analysis was scheduled for just after the data center received the final clinical review form of the 300th patient. RESULTS: The interim analysis revealed a significant difference in the primary endpoint. In the final analysis, thrombus was identified in 16 of 88 LUL patients (20.5%), and in 4 of 247 patients who underwent other types of lobectomy (1.6%) (p < 0.05). Cerebral infarction was identified in 1 of the LUL patients (1.3%) and in 9 of the other patients (3.6%) (p = 0.318). CONCLUSIONS: Thrombus frequently forms at the stump of the left superior pulmonary vein after LUL. However, our study did not identify a relationship between thrombosis and cerebral infarction.

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Establishment and validation of reference values for abdominal skeletal muscle compartments in children.

Wataru Kudo, Keita Terui, Shinya Hattori, Ayako Takenouchi, Shugo Komatsu, Satoru Oita, Yasunori Sato, Tomoro Hishiki

Clinical nutrition (Edinburgh, Scotland) (Clinical Nutrition)  42 ( 5 ) 653 - 660 2023.05

ISSN  0261-5614

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BACKGROUND & AIMS: Sarcopenia, resulting from skeletal muscle loss, is a serious concern in children, for whom nutrition and physical activity are essential for growth. In sarcopenia research, the skeletal muscle mass is often obtained from computed tomography (CT) cross-sectional images in both adults and children; however, the method of evaluating skeletal muscle using CT, especially the area range to be measured, has not yet been validated in children. The aim of this study is to establish reference values for three compartments of the abdominal skeletal muscle area (aSMA) obtained from cross-sectional CT images, and to validate the differences among them by assessing correlations with physical development. METHODS: We conducted a single-centre, retrospective, cross-sectional study and included patients aged 1-17 years who underwent abdominal CT at Chiba University Hospital from 2007 to 2020. Patients with chronic diseases such as malignant tumours and inflammatory bowel disease were excluded from the analysis. aSMA was obtained from CT cross-sections at the lumbar L3-L4 intervertebral disc level by dividing it into three compartments: the psoas muscle area (PMA), paraspinal muscle area (PSMA), and total skeletal muscle area (TSMA). Quartile regression curves by sex and muscle compartment were generated using non-crossover and nonparametric regression quantile estimation. The correlation between each compartment of aSMA with height and weight was assessed using Spearman's rank correlation coefficient. RESULTS: We analysed the abdominal CT images of 593 children (male: n = 335, female: n = 258) and generated curves predictive for the 5th, 25th, 50th, 75th, and 95th percentiles for each compartment of aSMA by sex. In patients aged 13 years and older, boys had significantly larger aSMA areas than girls in all three compartments. Among the three compartments, PSMA had the strongest correlation coefficient with height and weight for both boys and girls. CONCLUSIONS: We generated quantile regression curves for three aSMA compartments obtained from cross-sectional CT images and established reference values in children. PSMA values were most strongly correlated with height and weight among the three aSMA compartments.

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Impact of respiratory bacterial infections on mortality in Japanese patients with COVID-19: a retrospective cohort study.

Nakagawara K, Kamata H, Chubachi S, Namkoong H, Tanaka H, Lee H, Otake S, Fukushima T, Kusumoto T, Morita A, Azekawa S, Watase M, Asakura T, Masaki K, Ishii M, Endo A, Koike R, Ishikura H, Takata T, Matsushita Y, Harada N, Kokutou H, Yoshiyama T, Kataoka K, Mutoh Y, Miyawaki M, Ueda S, Ono H, Ono T, Shoko T, Muranaka H, Kawamura K, Mori N, Mochimaru T, Fukui M, Chihara Y, Nagasaki Y, Okamoto M, Amishima M, Odani T, Tani M, Nishi K, Shirai Y, Edahiro R, Ando A, Hashimoto N, Ogura S, Kitagawa Y, Kita T, Kagaya T, Kimura Y, Miyazawa N, Tsuchida T, Fujitani S, Murakami K, Sano H, Sato Y, Tanino Y, Otsuki R, Mashimo S, Kuramochi M, Hosoda Y, Hasegawa Y, Ueda T, Takaku Y, Ishiguro T, Fujiwara A, Kuwahara N, Kitamura H, Hagiwara E, Nakamori Y, Saito F, Kono Y, Abe S, Ishii T, Ohba T, Kusaka Y, Watanabe H, Masuda M, Watanabe H, Kimizuka Y, Kawana A, Kasamatsu Y, Hashimoto S, Okada Y, Takano T, Katayama K, Ai M, Kumanogoh A, Sato T, Tokunaga K, Imoto S, Kitagawa Y, Kimura A, Miyano S, Hasegawa N, Ogawa S, Kanai T, Fukunaga K, Japan COVID-19 Task Force

BMC pulmonary medicine 23 ( 1 ) 146 2023.04

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Artificial intelligence to estimate the tear film breakup time and diagnose dry eye disease.

Eisuke Shimizu, Toshiki Ishikawa, Makoto Tanji, Naomichi Agata, Shintaro Nakayama, Yo Nakahara, Ryota Yokoiwa, Shinri Sato, Akiko Hanyuda, Yoko Ogawa, Masatoshi Hirayama, Kazuo Tsubota, Yasunori Sato, Jun Shimazaki, Kazuno Negishi

Scientific reports (Scientific Reports)  13 ( 1 ) 5822 - 5822 2023.04

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The use of artificial intelligence (AI) in the diagnosis of dry eye disease (DED) remains limited due to the lack of standardized image formats and analysis models. To overcome these issues, we used the Smart Eye Camera (SEC), a video-recordable slit-lamp device, and collected videos of the anterior segment of the eye. This study aimed to evaluate the accuracy of the AI algorithm in estimating the tear film breakup time and apply this model for the diagnosis of DED according to the Asia Dry Eye Society (ADES) DED diagnostic criteria. Using the retrospectively corrected DED videos of 158 eyes from 79 patients, 22,172 frames were annotated by the DED specialist to label whether or not the frame had breakup. The AI algorithm was developed using the training dataset and machine learning. The DED criteria of the ADES was used to determine the diagnostic performance. The accuracy of tear film breakup time estimation was 0.789 (95% confidence interval (CI) 0.769-0.809), and the area under the receiver operating characteristic curve of this AI model was 0.877 (95% CI 0.861-0.893). The sensitivity and specificity of this AI model for the diagnosis of DED was 0.778 (95% CI 0.572-0.912) and 0.857 (95% CI 0.564-0.866), respectively. We successfully developed a novel AI-based diagnostic model for DED. Our diagnostic model has the potential to enable ophthalmology examination outside hospitals and clinics.

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Diagnostic significance of secondary bacteremia in patients with COVID-19.

Nakagawara K, Kamata H, Chubachi S, Namkoong H, Tanaka H, Lee H, Otake S, Fukushima T, Kusumoto T, Morita A, Azekawa S, Watase M, Asakura T, Masaki K, Ishii M, Endo A, Koike R, Ishikura H, Takata T, Matsushita Y, Harada N, Kokutou H, Yoshiyama T, Kataoka K, Mutoh Y, Miyawaki M, Ueda S, Ono H, Ono T, Shoko T, Muranaka H, Kawamura K, Mori N, Mochimaru T, Fukui M, Chihara Y, Nagasaki Y, Okamoto M, Amishima M, Odani T, Tani M, Nishi K, Shirai Y, Edahiro R, Ando A, Hashimoto N, Ogura S, Kitagawa Y, Kita T, Kagaya T, Kimura Y, Miyazawa N, Tsuchida T, Fujitani S, Murakami K, Sano H, Sato Y, Tanino Y, Otsuki R, Mashimo S, Kuramochi M, Hosoda Y, Hasegawa Y, Ueda T, Takaku Y, Ishiguro T, Fujiwara A, Kuwahara N, Kitamura H, Hagiwara E, Nakamori Y, Saito F, Kono Y, Abe S, Ishii T, Ohba T, Kusaka Y, Watanabe H, Masuda M, Watanabe H, Kimizuka Y, Kawana A, Kasamatsu Y, Hashimoto S, Okada Y, Takano T, Katayama K, Ai M, Kumanogoh A, Sato T, Tokunaga K, Imoto S, Kitagawa Y, Kimura A, Miyano S, Hasegawa N, Ogawa S, Kanai T, Fukunaga K, Japan COVID-19 Task Force

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 29 ( 4 ) 422 - 426 2023.04

ISSN  1341-321X

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Reduced versus maximum tolerated methotrexate dose concomitant with adalimumab in patients with rheumatoid arthritis (MIRACLE): a randomised, open-label, non-inferiority trial

Tamai H., Ikeda K., Miyamoto T., Taguchi H., Kuo C.F., Shin K., Hirata S., Okano Y., Sato S., Yasuoka H., Kuwana M., Ishii T., Kameda H., Kojima T., Taninaga T., Mori M., Miyagishi H., Sato Y., Tsai W.C., Takeuchi T., Kaneko Y., Izumi K., Kondo Y., Yoshimoto K., Gono T., Park S.H., Baek H.J., Lee Y.J., Choi I.A., Kim J., Hsu P.N., Huan C.M., Weng M.Y., Sung W.Y., Cheng T.T.

The Lancet Rheumatology (The Lancet Rheumatology)  5 ( 4 ) e215 - e224 2023.04

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Background: Efficacy of combination therapy with methotrexate and biological disease-modifying antirheumatic drugs is well established in the management of patients with rheumatoid arthritis; however, the optimal dose of methotrexate to administer with a tumour necrosis factor inhibitor remains unclear. We aimed to clarify the efficacy and safety of adalimumab combined with reduced methotrexate dose compared with the maximum tolerated methotrexate dose in patients with rheumatoid arthritis and an inadequate response to methotrexate monotherapy. Methods: In this open-label, randomised controlled trial, we recruited methotrexate-naive patients with rheumatoid arthritis and a disease duration of less than 2 years across 24 secondary or tertiary care hospitals across Japan, South Korea, and Taiwan. At initiation, methotrexate was given orally and increased to the maximum tolerated dose by week 12. Patients who did not achieve remission on the basis of the Simplified Disease Activity Index (SDAI) at week 24 were randomly assigned (1:1) to receive adalimumab (40 mg biweekly) combined with a continued maximum tolerated dose of methotrexate or adalimumab combined with a reduced dose of methotrexate. The primary endpoint was non-inferiority of adalimumab plus reduced-dose methotrexate to adalimumab plus maximal-dose methotrexate based on SDAI remission at week 48, assessed in the modified full-analysis set with a pre-specified non-inferiority margin of −15%, based on a two-sided 90% CI. Adverse events were assessed in the safety analysis set. This trial is registered with ClinicalTrials.gov, NCT03505008 and has been completed. Findings: From April 18, 2018, to June 2, 2020, from 323 patients screened, 300 were enrolled, and 291 patients were included in the full analysis set. The mean age was 57·7 years (SD 15·2), 217 (75%) were female, 74 (25%) were male, and all patients were of Asian ethnicity. The mean SDAI at study enrolment was 26·5 (SD 12·4). 52 patients discontinued the study before week 24 or at week 24 before randomisation. At week 24, 105 (36%) of 291 patients achieved remission and continued methotrexate monotherapy through week 48. 134 (46%) did not achieve remission at week 24 and were randomly assigned to receive adalimumab plus the maximum tolerated dose of methotrexate (n=68) or adalimumab plus reduced-dose methotrexate (n=66). Remission at week 48 was achieved in 25 (38%) of 66 and 27 (44%) of 61 patients, respectively, with an adjusted risk difference of 6·4% (90% CI −7·0 to 19·8), which met the non-inferiority margin of −15%. Adverse events after week 24 tended to be more frequent in the maximum tolerated dose group than in the reduced-dose group (24 [35%] vs 13 [20%], p=0·054). Between week 24 and 48, there were 14 serious adverse events (6 in the methotrexate monotherapy group, 5 in the adalimumab plus maximal-dose methotrexate, and 3 in the adalimumab plus reduced-dose methotrexate group), and no deaths. Interpretation: The MIRACLE study showed that the efficacy of adalimumab combined with reduced methotrexate dose was not inferior to that with the maximum tolerated methotrexate dose, with a tendency to a better safety profile. Funding: Eisai.

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Epidemiological and clinical characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease in a nationwide survey.

Masashi Nakamura, Ryo Ogawa, Juichi Fujimori, Akiyuki Uzawa, Yasunori Sato, Kengo Nagashima, Nagato Kuriyama, Satoshi Kuwabara, Ichiro Nakashima

Multiple sclerosis (Houndmills, Basingstoke, England) (Multiple Sclerosis Journal)  29 ( 4-5 ) 530 - 539 2023.04

ISSN  1352-4585

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BACKGROUND: To our knowledge, no nationwide epidemiological study of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has been conducted. OBJECTIVE: We examined the epidemiology and clinical features of MOGAD in Japan. METHODS: We distributed questionnaires on the clinical characteristics of patients with MOGAD to neurology, pediatric-neurology, and neuro-ophthalmology facilities throughout Japan. RESULTS: In total, 887 patients were identified. The estimated number of total and newly diagnosed MOGAD patients was 1,695 [95% confidence interval (CI): 1483-1907] and 487 (95% CI: 414-560), respectively. The estimated prevalence and incidence were 1.34/100,000 (95% CI: 1.18-1.51) and 0.39/100,000 (95% CI: 0.32-0.44), respectively. The median age at onset was 28 years (range: 0-84 years). At onset, optic neuritis was present in approximately 40% of patients, irrespective of the onset age. Acute disseminated encephalomyelitis was more frequent in younger patients, whereas brainstem encephalitis, encephalitis, and myelitis were more frequent in elderly patients. Immunotherapy was highly effective. CONCLUSION: The prevalence and incidence rates of MOGAD in Japan are similar to those in other countries. Notable characteristics such as the preferential occurrence of acute disseminated encephalomyelitis in children exist; however, general characteristics including symptoms and treatment response are common irrespective of the onset age.

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A systematic review and meta-analysis of the clinical impact of stopping renin-angiotensin system inhibitor in patients with chronic kidney disease.

Takashin Nakayama, Ryunosuke Mitsuno, Tatsuhiko Azegami, Yasunori Sato, Kaori Hayashi, Hiroshi Itoh

Hypertension research : official journal of the Japanese Society of Hypertension (Hypertension Research)   2023.03

ISSN  0916-9636

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Although renin-angiotensin system (RAS) inhibitors reduce the risk of cardiovascular diseases and end-stage kidney disease (ESKD) in chronic kidney disease (CKD) patients, they are often discontinued in clinical practice due to drug-related adverse events. However, limited evidence is available about the clinical impact of RAS inhibitor discontinuation in CKD patients. A comprehensive search of publications investigating the effect of discontinuing RAS inhibitors on clinical outcomes in CKD patients in PubMed, the Cochrane Library, and Web of Science was conducted (inception to November 7, 2022), and potentially relevant studies were searched by hand (through November 30, 2022). Two reviewers independently extracted data according to the PRISMA and MOOSE guidelines and assessed the quality of each study with risk-of-bias tools, RoB2 and ROBINS-I. The pooled hazard ratio (HR) for each outcome was integrated with a random-effect model. A total of 1 randomized clinical trial and 6 observational studies involving 248,963 patients were included in the systematic review. The meta-analysis of observational studies showed that discontinuation of RAS inhibitors was associated with a higher risk of all-cause mortality (HR, 1.41 [95% CI, 1.23-1.62]; I2 = 97%), ESKD (1.32 [95% CI, 1.10-1.57]; I2 = 94%) and MACE (1.20 [95% CI 1.15-1.25]; I2 = 38%), but not with hyperkalemia (0.79 [95% CI 0.55-1.15]; I2 = 90%). Overall risk of bias was moderate-to-serious, and quality of evidence (GRADE system) was low-to-very low. The present study suggests that CKD patients would benefit from continuing RAS inhibitors.

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Comparison of Surgical Outcomes of Anterior and Posterior Fusion Surgeries for K-line (-) Cervical Ossification of the Posterior Longitudinal Ligament: A Prospective Multicenter Study.

Narihito Nagoshi, Toshitaka Yoshii, Satoru Egawa, Kenichiro Sakai, Kazuo Kusano, Shunji Tsutsui, Takashi Hirai, Yu Matsukura, Kanichiro Wada, Keiichi Katsumi, Masao Koda, Atsushi Kimura, Takeo Furuya, Yasunori Sato, Satoshi Maki, Norihiro Nishida, Yukitaka Nagamoto, Yasushi Oshima, Kei Ando, Hiroaki Nakashima, Masahiko Takahata, Kanji Mori, Hideaki Nakajima, Kazuma Murata, Masayuki Miyagi, Takashi Kaito, Kei Yamada, Tomohiro Banno, Satoshi Kato, Tetsuro Ohba, Hiroshi Moridaira, Shunsuke Fujibayashi, Hiroyuki Katoh, Haruo Kanno, Kota Watanabe, Hiroshi Taneichi, Shiro Imagama, Yoshiharu Kawaguchi, Katsushi Takeshita, Masaya Nakamura, Morio Matsumoto, Masashi Yamazaki

Spine  2023.03

ISSN  0362-2436

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STUDY DESIGN: A prospective multicenter study. OBJECTIVE: To compare the surgical outcomes of anterior and posterior fusion surgeries in patients with K-line (-) cervical ossification of the posterior longitudinal ligament (OPLL). SUMMARY OF BACKGROUND DATA: Although laminoplasty is effective for patients with K-line (+) OPLL, fusion surgery is recommended for those with K-line (-) OPLL. However, whether the anterior or posterior approach is preferable for this pathology has not been effectively determined. METHODS: A total of 478 patients with myelopathy due to cervical OPLL from 28 institutions were prospectively registered from 2014 to 2017 and followed up for 2 years. Of the 478 patients, 45 and 46 with K-line (-) underwent anterior and posterior fusion surgeries, respectively. After adjusting for confounders in baseline characteristics using a propensity score-matched analysis, 54 patients in both the anterior and posterior groups (27 patients each) were evaluated. Clinical outcomes were assessed using the cervical Japanese Orthopaedic Association and the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire. RESULTS: Both approaches showed comparable neurological and functional recovery. The cervical range of motion was significantly restricted in the posterior group because of the large number of fused vertebrae compared with the anterior group. The incidence of surgical complications was comparable between the cohorts, but the posterior group demonstrated a higher frequency of segmental motor paralysis, whereas the anterior group more frequently reported postoperative dysphagia. CONCLUSION: Clinical improvement was comparable between anterior and posterior fusion surgeries for patients with K-line (-) OPLL. The ideal surgical approach should be informed based on the balance between the surgeon's technical preference and the risk of complications.

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Estimating immunity with mathematical models for SARS-CoV-2 after COVID-19 vaccination.

Yoshifumi Uwamino, Kengo Nagashima, Ayumi Yoshifuji, Shigeru Suga, Mizuho Nagao, Takao Fujisawa, Munekazu Ryuzaki, Yoshiaki Takemoto, Ho Namkoong, Masatoshi Wakui, Hiromichi Matsushita, Naoki Hasegawa, Yasunori Sato, Mitsuru Murata

NPJ vaccines (Springer Science and Business Media LLC)  8 ( 1 ) 33 - 33 2023.03

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Abstract

Tools that can be used to estimate antibody waning following COVID-19 vaccinations can facilitate an understanding of the current immune status of the population. In this study, a two-compartment-based mathematical model is formulated to describe the dynamics of the anti-SARS-CoV-2 antibody in healthy adults using serially measured waning antibody concentration data obtained in a prospective cohort study of 673 healthcare providers vaccinated with two doses of BNT162b2 vaccine. The datasets of 165 healthcare providers and 292 elderly patients with or without hemodialysis were used for external validation. Internal validation of the model demonstrated 97.0% accuracy, and external validation of the datasets of healthcare workers, hemodialysis patients, and nondialysis patients demonstrated 98.2%, 83.3%, and 83.8% accuracy, respectively. The internal and external validations demonstrated that this model also fits the data of various populations with or without underlying illnesses. Furthermore, using this model, we developed a smart device application that can rapidly calculate the timing of negative seroconversion.

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SECを使用した眼科診断AI・遠隔診療を活用した離島、地域医療、医療過疎地への調査研究

清水 映輔, 坪田 一男, 小川 葉子, 藤島 浩, 深川 和巳, 佐藤 泰憲, 矢津 啓之, 羽入田 明子, 佐藤 真理, 片山 泰一郎, 中山 慎太郎, 丹治 信, 逆瀬川 光人, 石川 敬規

大和証券ヘルス財団研究業績集 ((公財)大和証券ヘルス財団)   ( 46 ) 55 - 59 2023.03

Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine.

Yoshifumi Uwamino, Takashi Yokoyama, Yasunori Sato, Ayako Shibata, Toshinobu Kurafuji, Akiko Tanabe, Masayo Noguchi, Tomoko Arai, Akemi Ohno, Hiromitsu Yokota, Ho Namkoong, Tomoyasu Nishimura, Kenjiro Kosaki, Naoki Hasegawa, Masatoshi Wakui, Mitsuru Murata, Hiromichi Matsushita

Vaccine (Vaccine)  41 ( 9 ) 1545 - 1549 2023.02

ISSN  0264-410X

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Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose. UMIN Clinical Trials Registry ID: UMIN000043340.

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Mean annual intradialytic blood pressure decline and cardiovascular events in Japanese patients on maintenance hemodialysis.

Rina Takahashi, Kiyotaka Uchiyama, Naoki Washida, Keigo Shibagaki, Akane Yanai, Takashin Nakayama, Kengo Nagashima, Yasunori Sato, Takeshi Kanda, Hiroshi Itoh

Hypertension research : official journal of the Japanese Society of Hypertension (Hypertension Research)     In press 2023.02

Accepted,  ISSN  0916-9636

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An intradialytic systolic blood pressure (SBP) decline, which defines intradialytic hypotension, may be associated with higher all-cause mortality. However, in Japanese patients on hemodialysis (HD), the association between intradialytic SBP decline and patient outcomes is unclear. This retrospective cohort study included 307 Japanese patients undergoing HD over 1 year in three dialysis clinics and evaluated the association between the mean annual intradialytic SBP decline (predialysis SBP-nadir intradialytic SBP) and clinical outcomes, including major adverse cardiovascular events (MACEs; cardiovascular death, nonfatal myocardial infarction or unstable angina, stroke, heart failure, and other severe cardiovascular events requiring hospitalization) by following up for 2 years. The mean annual intradialytic SBP decline was 24.2 (25-75th percentile, 18.3-35.0) mmHg. In the model fully adjusted for intradialytic SBP decline tertile group (T1, <20.4 mmHg; T2, 20.4 to <29.9 mmHg; T3, ≥29.9 mmHg), predialysis SBP, age, sex, HD vintage, Charlson comorbidity index, ultrafiltration rate, use of renin-angiotensin system inhibitors, corrected calcium, phosphorus, human atrial natriuretic peptide, geriatric nutritional risk index, normalized protein catabolism rate, C-reactive protein, hemoglobin, and use of pressor agents, Cox regression analyses showed that the hazard ratio (HR) was significantly higher for T3 than for T1 for MACEs (HR, 2.38; 95% confidence interval 1.12-5.09) and all-cause hospitalization (HR, 1.68; 95% confidence interval 1.03-2.74). Therefore, in Japanese patients on HD, a greater intradialytic SBP decline was associated with worse clinical outcomes. Further studies are warranted to investigate whether interventions to attenuate the intradialytic SBP decline will improve the prognosis of Japanese patients on HD.

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Five-Year Outcomes of the Bioresorbable Peripheral Remedy Stent in the Treatment of Iliac Artery Disease.

Hideaki Obara, Kentaro Matsubara, Naoki Fujimura, Hirohisa Harada, Masaharu Okada, Jun Okui, Yasunori Sato, Keiichi Fukuda, Yuko Kitagawa

Journal of vascular and interventional radiology : JVIR (Journal of Vascular and Interventional Radiology)  34 ( 6 ) 1024 - 1035.e2 2023.02

ISSN  1051-0443

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PURPOSE: To evaluate the 5-year performance of a bioresorbable vascular scaffold, the Remedy stent, for the treatment of iliac artery atherosclerotic disease. MATERIALS AND METHODS: This prospective, multicenter, single-arm clinical study evaluated 97 patients (97 lesions) with symptomatic TransAtlantic Inter-Society Consensus II A/B iliac artery lesions for 5 years after stent placement. The primary efficacy end point was 12-month primary patency compared with the prespecified standard derived from historical data with metallic stents, and the primary safety end point was the occurrence of major adverse clinical events within 5 years. All angiographic and computed tomography angiographic findings were evaluated by an independent core laboratory for quantitative vessel analysis. RESULTS: The 12-month primary patency rate was 88.6% (95% CI, 80.1%-94.4%), which was lower than the prespecified standard. No significant difference was noted between the diameter stenosis at 9 and 12 months. There were no device- or procedure-related deaths, major amputation, or distal embolization during the follow-up period. The ankle-brachial index maintained significant improvement through the 5-year period compared with that at baseline. The Kaplan-Meier estimates of freedom from target lesion revascularization (TLR), major adverse cardiovascular events, and major adverse cardiovascular and limb events were 95.8%, 91.7%, and 87.5% at 12 months and 85.4%, 72.1%, and 62.5% at 5 years, respectively. CONCLUSIONS: The 5-year follow-up outcomes, including freedom from TLR, of the Remedy stent in iliac artery lesions were satisfactory, with a good safety profile. Nevertheless, the 12-month primary patency did not meet the expected standard compared with that of contemporary metallic stents.

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Predictors of Improvement in Exercise Tolerance After Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension.

Kyohei Daigo, Yoshinori Katsumata, Kosho Esaki, Yuji Iwasawa, Genki Ichihara, Kotaro Miura, Kohsuke Shirakawa, Yasunori Sato, Kazuki Sato, Keiichi Fukuda

Journal of the American Heart Association (Journal of the American Heart Association)  12 ( 3 ) e8137 2023.02

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Background Balloon pulmonary angioplasty (BPA) improves exercise tolerance and hemodynamic parameters in patients with chronic thromboembolic pulmonary hypertension. However, it is still unclear which patient characteristics contribute to the improvement in exercise tolerance after BPA in chronic thromboembolic pulmonary hypertension. Methods and Results We retrospectively analyzed 126 patients with chronic thromboembolic pulmonary hypertension (aged 63±14 years; female, 65%) who underwent BPA without concomitant programmed exercise rehabilitation at Keio University between November 2012 and April 2018. Hemodynamic data and 6-minute walk distance (6MWD), as a measure of exercise tolerance, were evaluated before and 1 year after BPA. The clinical characteristics that contributed to improvement in exercise tolerance were elucidated. The 6MWD significantly increased from 372.0 m (256.5-431.3) to 462.0 m (378.8-537.0) 1 year after BPA (P<0.001). The improvement rate in the 6MWD after BPA exhibited a good correlation with age, height, mean pulmonary artery pressure, and 6MWD at baseline (Spearman rank correlation coefficients=-0.28, 0.24, -0.40, and 0.44, respectively). Additional multivariable linear regression analysis revealed that young age, tall height, high mean pulmonary artery pressure, short 6MWD at baseline, and high lung capacity at baseline were significant predictors of the improvement in 6MWD by BPA (standardized partial regression coefficient -0.39, 0.22, 0.19, -0.62, and 0.25, P<0.001, 0.007, 0.011, <0.001, and <0.001, respectively). Conclusions BPA without concomitant programmed exercise rehabilitation significantly improves exercise tolerance. This was particularly true in young patients with high stature, high mean pulmonary artery pressure, short 6MWD, and lung capacity at the time of diagnosis.

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成人食物アレルギー診療支援アプリの開発と有用性の検証

正木 克宜, 冨保 紗希, 上條 慎太郎, 安藤 崇之, 加畑 宏樹, 佐藤 泰憲, 原田 紀宏, 鈴木 慎太郎, 藤澤 隆夫, 福永 興壱

日本内科学会雑誌 ((一社)日本内科学会)  112 ( 臨増 ) 190 - 190 2023.02

ISSN  0021-5384

PEDIATRIC BLOOD PRESSURE CATEGORY PREDICTS LONGITUDINAL VARIABILITY IN BLOOD PRESSURE IN YOUTH

Azegami Tatsuhiko, Uchida Keiko, Sato Yasunori, Takeda Ayano, Inokuchi Mikako, Itoh Hiroshi, Mori Masaaki

JOURNAL OF HYPERTENSION 41   E321 - E321 2023.01

ISSN  0263-6352

Impact of coronavirus disease 2019 on the number of newly diagnosed cancer patients and examinations and surgeries performed for cancer in Japan: a nationwide study.

Takeshi Terashima, Hiroshi Konishi, Yasunori Sato, Muneki Igarashi, Takafumi Yanagibashi, Ryo Konno, Hideyuki Saya, Yuichiro Doki, Tadao Kakizoe

BMC cancer (BMC Cancer)  22 ( 1 ) 1303 - 1303 2022.12

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BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has rapidly and dramatically influenced healthcare across Japan. However, the influence of the COVID-19 pandemic on the number of newly diagnosed cancer, surgical treatment, and diagnostic examination for cancer types have not been completely investigated all over Japan. This study aimed to analyze the number of cases before and during the COVID-19 pandemic. METHODS: This retrospective study was a survey that asked to provide the number of cases diagnosed with gastric, colorectal, lung, breast, and cervical cancer between January 2019 and December 2020. The survey was sent to tertiary healthcare hospitals, including national cancer institutions, university hospitals, and general hospitals, all over Japan. Data obtained from 105 of 486 surveyed hospitals were evaluated, and the number of cases in each quarter in 2020 was compared with that in the equivalent quarter in 2019. RESULTS: In the second quarter (Q2), significant reductions were observed in the median number of newly diagnosed cases from 2019 to 2020: gastric cancer, 26.7% (43 vs. 32, p <  0.001); colorectal cancer, 17.9% (52 vs. 40, p <  0.001); lung cancer, 12.3% (53.5 vs. 47, p <  0.001); and breast cancer, 13.1% (43 vs. 35.5, p <  0.001). A significant reduction of 11.4% (9 vs. 8, p = 0.03) was observed in the third quarter (Q3) for cervical cancer. In Q2, the number of cases decreased by 30.9% (25 vs. 15, p <  0.001) for stage I gastric cancer, by 27.3% (12 vs. 9, p <  0.001) for stage I colorectal cancer, and by 17.6% (13 vs. 10, p <  0.001) for stage II breast cancer. The magnitude of reduction was significant for the localized stages of gastric, colorectal, and breast cancer according to diagnostic examinations in Q2 and surgical and endoscopic treatment in Q3 rather than that for lung or cervical cancer. CONCLUSIONS: COVID-19 has prolonged collateral effects on cancer care, including examination, diagnosis, and surgery, with significant effects on gastric cancer, followed by colorectal, lung, breast, and cervical cancer in Japan.

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A predictive scoring system for small diaphragmatic defects in infants with congenital diaphragmatic hernia.

Keita Terui, Kouji Nagata, Masaya Yamoto, Masahiro Hayakawa, Hiroomi Okuyama, Shoichiro Amari, Akiko Yokoi, Taizo Furukawa, Kouji Masumoto, Tadaharu Okazaki, Noboru Inamura, Katsuaki Toyoshima, Yuhki Koike, Manabu Okawada, Yasunori Sato, Noriaki Usui

Pediatric surgery international (Pediatric Surgery International)  39 ( 1 ) 4 - 4 2022.11

ISSN  0179-0358

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PURPOSE: To develop a predictive score for small diaphragmatic defects in infants with congenital diaphragmatic hernia (CDH) for determining thoracoscopic surgery indication. METHODS: The Japanese CDH Study Group cohort was randomly divided into derivation (n = 397) and validation (n = 396) datasets. Using logistic regression, a prediction model and weighted scoring system for small diaphragmatic defects were created from derivation dataset and validated with validation dataset. RESULTS: Six weighted variables were selected: no hydramnios, 1 point; 1 min Apgar score of 5-10, 1 point; apex type of the lung (left lung is detected radiographically in apex area), 1 point; oxygenation index < 8, 1 point; abdominal nasogastric tube (tip of the nasogastric tube is detected radiographically in the abdominal area), 2 points; no right-to-left flow of ductus arteriosus, 1 point. In validation dataset, rates of small diaphragmatic defects for Possible (0-3 points), Probable (4-5 points), and Definite (6-7 points) groups were 36%, 81%, and 94%, respectively (p < 0.001). Additionally, sensitivity, specificity, positive predictive value, and C statistics were 0.78, 0.79, 0.88, 0.76, and 0.45, 0.94, 0.94, 0.70 for Probable and Definite groups, respectively. CONCLUSION: Our scoring system effectively predicted small diaphragmatic defects in infants with CDH.

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Impact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study.

Nakagawara K, Chubachi S, Namkoong H, Tanaka H, Lee H, Azekawa S, Otake S, Fukushima T, Morita A, Watase M, Sakurai K, Kusumoto T, Asakura T, Masaki K, Kamata H, Ishii M, Hasegawa N, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Edahiro R, Murakami K, Sato Y, Okada Y, Koike R, Kitagawa Y, Tokunaga K, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K

Respiratory research (Respiratory Research)  23 ( 1 ) 315 2022.11

ISSN  1465-9921

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Background: Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients. Methods: This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1: no respiratory symptoms, Group 2: only upper respiratory symptoms, Group 3: only lower respiratory symptoms, and Group 4: both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death. Results: Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.11–0.39), while patients in Group 3 had the worst outcomes (OR: 3.27, 95% CI: 2.43–4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course. Conclusions: Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.

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Standards for assessing and reporting adverse events.

Takashi Kawakami, Shun Kohsaka, Yasunori Sato, Keiichi Fukuda, Hiromi Matsubara

The Lancet. Respiratory medicine  2022.11

ISSN  2213-2600

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Adverse effects of long-term drain placement and the importance of direct aspiration: A retrospective cohort study.

Jun Okui, Hideaki Obara, Shunsuke Uno, Yasunori Sato, Gaku Shimane, Masashi Takeuchi, Hirofumi Kawakubo, Minoru Kitago, Koji Okabayashi, Yuko Kitagawa

The Journal of hospital infection  2022.11

ISSN  0195-6701

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BACKGROUND: Long-term placement of prophylactic drains can result in retrograde infections. AIM: We aimed to investigate the association between the timing of drain removal and clinical outcomes. METHODS: This retrospective, single-center cohort study evaluated 110 patients who underwent elective gastrointestinal or hepatopancreatobiliary surgery and developed subsequent organ/space surgical site infection (SSI) between 2016 and 2020. We evaluated the difference between the culture-positive species of prophylactic drains and direct aspiration, whether the prophylactic drains functioned effectively at the time of SSI diagnosis, and whether the empirical antibiotics administered before drainage were able to treat all the detected bacteria. Finally, clinical outcomes were compared between early (i.e. cases wherein the prophylactic drain had already been removed or replaced at the time of SSI diagnosis) and late (removal after diagnosis) drain removal. FINDINGS: The prophylactic drains functioned effectively in only 27 (25%) patients at the time of SSI diagnosis. Due to the results of direct aspiration cultures, 43% of patients required antibiotic escalation. The median time to drain removal or first replacement was seven postoperative days. The early removal group included 43 patients (39%). Compared with early removal, late removal resulted in a higher frequency of vancomycin use (7.0% versus 22.4%; P = 0.037). CONCLUSIONS: Prolonged prophylactic drain placement is associated with complicated infections requiring vancomycin, therefore, the drains should be removed as soon as possible. Additionally, obtaining the cultures of direct aspiration should be actively considered, as escalation of antimicrobial therapy is often performed based on culture results.

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肺癌脳転移に対する定位放射線治療の最近の傾向　単施設における20年余2456例の経験から

山本 昌昭, 佐藤 泰憲

肺癌 ((NPO)日本肺癌学会)  62 ( 6 ) 621 - 621 2022.11

ISSN  0386-9628

認知症家族介護者の心理的負担に対する集団複合的介入プログラムの効果研究

田村 法子, 色本 涼, 長島 健悟, 佐藤 泰憲, 中川 敦夫, 三村 將, 藤澤 大介

老年精神医学雑誌 ((株)ワールドプランニング)  33 ( 増刊II ) 352 - 353 2022.11

ISSN  0915-6305

School-based cognitive behavioural intervention programme for addressing anxiety in 10- to 11-year-olds using short classroom activities in Japan: a quasi-experimental study.

Urao Y, Yoshida M, Sato Y, Shimizu E

BMC psychiatry 22 ( 1 ) 658 2022.10

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Assessing anti-SARS-CoV-2 cellular immunity in 571 vaccinees by using an interferon-γ release assay.

Wakui M, Uwamino Y, Yatabe Y, Nakagawa T, Sakai A, Kurafuji T, Shibata A, Tomita Y, Noguchi M, Tanabe A, Arai T, Ohno A, Yokota H, Uno S, Yamasawa W, Sato Y, Ikeda M, Yoshimura A, Hasegawa N, Saya H, Murata M

European journal of immunology  2022.10

ISSN  0014-2980

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認知症家族介護者の心理的負担に対する集団複合的介入プログラムの効果研究

田村 法子, 色本 涼, 長島 健悟, 佐藤 泰憲, 中川 敦夫, 三村 將, 藤澤 大介

Dementia Japan ((一社)日本認知症学会)  36 ( 4 ) 800 - 800 2022.10

ISSN  1342-646X

抗MOG抗体関連疾患を対象とした全国疫学調査(第一報)

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 桑原 聡, 中島 一郎

神経免疫学 ((一社)日本神経免疫学会)  27 ( 1 ) 123 - 123 2022.10

ISSN  0918-936X

抗MOG抗体関連疾患を対象とした全国疫学調査(一次調査報告)

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 桑原 聡, 中島 一郎

臨床神経学 ((一社)日本神経学会)  62 ( Suppl. ) S218 - S218 2022.10

ISSN  0009-918X

将来の妊娠に備えた精神科治療　プレコンセプションケア向上を目的としたパンフレットによる教育的介入

小川 道, 橋本 佐, 石井 宏樹, 関 亮太, 佐藤 愛子, 橘 真澄, 木村 敦史, 山崎 香織, 椿 佳那子, 田中 麻未, 佐藤 泰憲, 新津 富央, 中里 道子, 伊豫 雅臣

日本周産期メンタルヘルス学会学術集会抄録集 (日本周産期メンタルヘルス学会)  18回   93 - 93 2022.10

大規模レジストリデータベースを活用したALS治験(ROPALS試験)におけるロピニロール塩酸塩の有効性の検証

高橋 愼一, 森本 悟, 伊東 大介, 伊達 悠岳, 岡田 健佑, Chyi Muh Chai, 西山 亜由美, 鈴木 直輝, 平井 美和, 加部 泰明, 末松 誠, 陣崎 雅弘, 青木 正志, 佐藤 泰憲, 中原 仁, 鈴木 則宏, 岡野 栄之

脳循環代謝 ((一社)日本脳循環代謝学会)  34 ( 1 ) 142 - 142 2022.10

ISSN  0915-9401

大規模レジストリデータベース(PRO-ACT)を活用したALSに対するロピニロール塩酸塩の有効性の検証

森本 悟, 高橋 愼一, 伊東 大介, 伊達 悠岳, 岡田 健佑, Chai Muh Chy, 西山 亜由美, 鈴木 直輝, 平井 美和, 加部 泰明, 末松 誠, 陣崎 雅弘, 青木 正志, 佐藤 泰憲, 中原 仁, 鈴木 則宏, 岡野 栄之

神経治療学 ((一社)日本神経治療学会)  39 ( 6 ) S257 - S257 2022.10

ISSN  0916-8443

ベッド脚下に設置した荷重センサーを用いた非接触非拘束ベッドセンサーシステムによる腹部手術患者の術後体重変化、生活パターン変化の観察研究

田口 奈津子, 孫 慶淑, 多羅尾 健太郎, 波照間 友基, 佐藤 泰憲, 磯野 史朗

日本医療ガス学会学術大会・総会プログラム・抄録集 (日本医療ガス学会)  25回   33 - 33 2022.10

MOG抗体関連疾患(MOGAD)の臨床と病態　MOG抗体関連疾患の疫学と臨床像

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 中島 一郎

神経治療学 ((一社)日本神経治療学会)  39 ( 6 ) S196 - S196 2022.10

ISSN  0916-8443

Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria.

Ogawa Y, Dana R, Kim S, Jain S, Rosenblatt MI, Perez VL, Clayton JA, Alves M, Rocha EM, Amparo F, Seo KY, Wang Y, Shen J, Oh JY, Vanathi M, Nair S, Na KS, Riemens A, Sippel K, Soifer M, Wang S, Ferrer MT, Kim MK, Yoon CH, Yagi R, Hiratsuka R, Ogawa M, Shimizu E, Sato Y, Pflugfelder S, Tsubota K

The ocular surface  2022.09

ISSN  1542-0124

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慢性血栓塞栓性肺高血圧症に対する肺動脈バルーン形成術後の運動耐容能改善に寄与する因子の検討

醍醐 恭平, 勝俣 良紀, 江嵜 康将, 岩澤 佑治, 市原 元気, 三浦 光太郎, 川上 崇史, 佐藤 泰憲, 佐藤 和毅, 福田 恵一

日本心臓病学会学術集会抄録 ((一社)日本心臓病学会)  70回   O - 41 2022.09

乳幼児期アレルギー疾患に関わる養育者負担評価票の開発　予備調査から見えてきたもの

水野 友美, 長尾 みづほ, 中川 敦夫, 佐藤 泰憲, 藤澤 隆夫

日本小児アレルギー学会誌 ((一社)日本小児アレルギー学会)  36 ( 4 ) 394 - 394 2022.09

ISSN  0914-2649

WJOG13219G: The Efficacy and Safety of FOLFOXIRI or Doublet plus Anti-VEGF Therapy in Previously Untreated BRAF^V600E Mutant Metastatic Colorectal Cancer: A Multi-Institutional Registry-Based Study (BRACELET Study).

Shimozaki K, Hirata K, Sato T, Nakamura M, Kato K, Hirano H, Kumekawa Y, Hino K, Kawakami K, Kito Y, Matsumoto T, Kawakami T, Komoda M, Nagashima K, Sato Y, Yamazaki K, Hironaka S, Takaishi H, Hamamoto Y, Muro K

Clinical colorectal cancer  2022.08

ISSN  1533-0028

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Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial.

Takashi Kawakami, Hiromi Matsubara, Toshiro Shinke, Kohtaro Abe, Shun Kohsaka, Kazuya Hosokawa, Yu Taniguchi, Hiroto Shimokawahara, Yoshitake Yamada, Masaharu Kataoka, Aiko Ogawa, Mitsushige Murata, Masahiro Jinzaki, Kenichi Hirata, Hiroyuki Tsutsui, Yasunori Sato, Keiichi Fukuda

The Lancet. Respiratory medicine  2022.08

ISSN  2213-2600

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BACKGROUND: Treatment options for patients with chronic thromboembolic pulmonary hypertension ineligible for pulmonary endarterectomy (inoperable CTEPH) include balloon pulmonary angioplasty (BPA) and riociguat. However, these two treatment options have not been compared prospectively. We aimed to compare the safety and efficacy of BPA and riociguat in patients with inoperable CTEPH. METHODS: This open-label, randomised controlled trial was conducted at four high-volume CTEPH centres in Japan. Patients aged 20-80 years with inoperable CTEPH (mean pulmonary arterial pressure ≥25 to <60 mm Hg and pulmonary artery wedge pressure ≤15 mm Hg) and WHO functional class II or III were randomly assigned (1:1) to BPA or riociguat via a computer program located at the registration centre using a minimisation method with biased-coin assignment. In the BPA group, the aim was for BPA to be completed within 4 months of the initial date of the first procedure. BPA was repeated until mean pulmonary arterial pressure decreased to less than 25 mm Hg. The frequency of BPA procedures depended on the difficulty and number of the lesions. In the riociguat group, 1·0 mg riociguat was administered orally thrice daily. When the systolic blood pressure was maintained at 95 mm Hg or higher, the dose was increased by 0·5 mg every 2 weeks up to a maximum of 2·5 mg thrice daily; dose adjustment was completed within 4 months of the date of the first dose. The primary endpoint was change in mean pulmonary arterial pressure from baseline to 12 months, measured in the full analysis set (patients who were enrolled and randomly assigned to one of the study treatments, and had at least one assessment after randomisation). BPA-related complications and indices related to clinical worsening were recorded throughout the study period. Adverse events were recorded throughout the study period and evaluated in the safety analysis set (patients who were enrolled and randomely assigned to one of the study treatments, and had received part of or all the study treatments). This trial is registered in the Japan Registry of Clinical Trials (jRCT; jRCTs031180239) and is completed. FINDINGS: Between Jan 8, 2016, and Oct 31, 2019, 61 patients with inoperable CTEPH were enrolled and randomly assigned to BPA (n=32) or riociguat (n=29). Patients in the BPA group underwent an average of 4·7 (SD 1·6) BPA procedures. In the riociguat group, the mean maintenance dose was 7·0 (SD 1·0) mg/day at 12 months. At 12 months, mean pulmonary arterial pressure had improved by -16·3 (SE 1·6) mm Hg in the BPA group and -7·0 (1·5) mm Hg in the riociguat group (group difference -9·3 mm Hg [95% CI -12·7 to -5·9]; p<0·0001). A case of clinical worsening of pulmonary hypertension occurred in the riociguat group, whereas none occurred in the BPA group. The most common adverse event was haemosputum, haemoptysis, or pulmonary haemorrhage, affecting 14 patients (44%) in the BPA group and one (4%) in the riociguat group. In 147 BPA procedures done in 31 patients, BPA-related complications were observed in 17 procedures (12%) in eight patients (26%). INTERPRETATION: Compared with riociguat, BPA was associated with a greater improvement in mean pulmonary arterial pressure in patients with inoperable CTEPH at 12 months, although procedure-related complications were reported. These findings support BPA as a reasonable option for inoperable CTEPH in centres with experienced BPA operators, with attention to procedure-related complications. FUNDING: Bayer Yakuhin. TRANSLATION: For the Japanese translation of the abstract see Supplementary Materials section.

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Synergistic Effect of Motivation for the Elderly and Support for Going out.

Yumi Mashimo, Saki Tsuchihashi, Kenta Tsutsui, Tomoyuki Arai, Yoshitaka Tsuji, Toshiaki Numai, Kazuo Kameda, Kyoko Nishizawa, Mami Kovacs, Shukichi Tanaka, Hiroki Watanabe, Yasushi Naruse, Mitsuyo Ohmura, Noriyuki Ishida, Toshiki Iwasaki, Gaku Hiruma, Naoki Miyazaki, Ryo Takemura, Kengo Nagashima, Yasunori Sato, Yui Ohtsu, Takashi Nakano, Naomi Aida, Isao Iizuka, Hiromi Kato, Yoshiki Kobayashi, Takaaki Senbonmatsu

Journal of personalized medicine 12 ( 8 )  2022.07

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Maintaining a social environment that enables going out freely is important for older people and aids the prevention of frailty syndrome. However, losing a driver's license can increase the long-term care needs of older people. Therefore, outing support systems are important. However, the utilization rate of these systems is currently relatively low. We conducted a demonstration experiment among older people aged 70 years and over, living in Iruma City, Saitama Japan, by implementing the Choisoko outing support system developed by Aisin Co., Ltd., in conjunction with an approach for improving motivation. Using this system, elderly people were able to go shopping freely whenever they chose, without a driver's license. Participants in the demonstration experiment exhibited higher Functional Independence Measure scores after the intervention, irrespective of whether or not they used the Choisoko system. The number of uses per person increased over time, and the subjective well-being of Choisoko users improved. However, few male participants engaged with the system. Although improving motivation is important for inducing positive behaviors and enabling the elderly to go out, motivation-improving factors differ between men and women.

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Trends in the incidence and etiology of acute pancreatitis from 2000 to 2016: A population-based study.

Horibe M, Ravella B, Chandra S, Sharma A, Sato Y, Vege SS

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]  2022.07

ISSN  1424-3903

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Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine.

Uwamino Y, Kurafuji T, Takato K, Sakai A, Tanabe A, Noguchi M, Yatabe Y, Arai T, Ohno A, Tomita Y, Shibata A, Yokota H, Yamasawa W, Namkoong H, Sato Y, Hasegawa N, Wakui M, Murata M, Keio Donner Project Team.

Vaccine  2022.06

ISSN  0264-410X

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The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.

Inagaki E, Arai E, Hatou S, Sayano T, Taniguchi H, Negishi K, Kanai Y, Sato Y, Okano H, Tsubota K, Shimmura S

Stem cells translational medicine  2022.06

ISSN  2157-6564

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Rocuronium versus saline for effective facemask ventilation during anesthesia induction: a double-blinded randomized placebo-controlled trial.

Ide A, Nozaki-Taguchi N, Sato S, Saito K, Sato Y, Isono S

BMC anesthesiology 22 ( 1 ) 173 2022.06

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【こころの臨床現場からの発信"いま"をとらえ、精神療法の可能性を探る】(第1部)臨床現場からの声　精神療法の可能性を探る　本邦における集団精神療法の現状と課題

藤澤 大介, 田島 美幸, 田村 法子, 近藤 裕美子, 大嶋 伸雄, 岡島 美朗, 岡田 佳詠, 菊地 俊暁, 耕野 敏樹, 佐藤 泰憲, 高橋 章郎, 中川 敦夫, 中島 美鈴, 横山 貴和子, 吉永 尚紀, 大野 裕

精神療法 ((株)金剛出版)   ( 増刊9 ) 98 - 103 2022.06

ISSN  0916-8710

EFFICACY AND SAFETY OF ADALIMUMAB WITH LOW AND HIGH DOSE-METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH INADEQUATE RESPONSE TO METHOTREXATE: THE RANDOMISED CONTROLLED MIRACLE STUDY

Tamai H., Ikeda K., Miyamoto T., Taguchi H., Kuo C. F., Shin K., Hirata S., Okano Y., Sato S., Yasuoka H., Choi I. A., Park S. H., Weng M. Y., Kuwana M., Lee Y. J., Ishii T., Kim J., Kameda H., Kojima T., Baek H. J., Hsu P. N., Huang C. M., Cheng T. T., Sung W. Y., Taninaga T., Mori M., Miyagishi H., Sato Y., Takeuchi T., Kaneko Y.

ANNALS OF THE RHEUMATIC DISEASES 81   42 - 43 2022.06

ISSN  0003-4967

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計算機科学を活用したヒトの有害事象研究の現状と展望　医療個別化のための臨床試験情報の系統的解析　慢性心不全患者の運動トレーニングの効果は薬物療法や病態に依存する

副島 裕佳子, 吉岡 秀樹, 佐藤 洋美, 畔 さゆり, 畠山 浩人, 佐藤 泰憲, 藤本 善英, 安西 尚彦, 樋坂 章博

The Journal of Toxicological Sciences ((一社)日本毒性学会)  47 ( Suppl. ) S27 - S27 2022.06

ISSN  0388-1350

Osteoporosis in nontuberculous mycobacterial pulmonary disease: a cross-sectional study.

Tanaka H, Asakura T, Suzuki S, Okamori S, Kusumoto T, Ogawa T, Uno S, Morita A, Lee H, Namkoong H, Kamata H, Sato Y, Uwamino Y, Nishimura T, Ishii M, Fukunaga K, Hasegawa N

BMC pulmonary medicine 22 ( 1 ) 202 2022.05

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Combination therapy of high-flow nasal cannula and upper body elevation for postoperative sleep disordered breathing; randomized cross-over trial.

Sakaguchi Y, Nozaki-Taguchi N, Hasegawa M, Ishibashi K, Sato Y, Isono S

Anesthesiology  2022.04

ISSN  0003-3022

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The associated factors of low birthweight among term singletons in Japan: a pregnancy birth registry analysis.

Kasuga Y, Iida M, Tanaka Y, Tamagawa M, Hasegawa K, Ikenoue S, Sato Y, Tanaka M, Ochiai D

Journal of epidemiology  2022.04

ISSN  0917-5040

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トホグリフロジンによる糖尿病大血管症の進展抑制効果の検討　UTOPIA Extension study

片上 直人, 三田 智也, 吉井 秀徳, 白岩 俊彦, 安田 哲行, 岡田 洋右, 黒住 旭, 馬屋原 豊, 金藤 秀明, 遅野井 健, 山本 恒彦, 栗林 伸一, 前田 和久, 横山 宏樹, 小杉 圭右, 林 功, 住谷 哲, 津川 真美子, 良本 佳代子, 加藤 研, 中村 正, 川嶋 聡, 佐藤 泰憲, 綿田 裕孝, 下村 伊一郎

糖尿病 ((一社)日本糖尿病学会)  65 ( Suppl.1 ) S - 143 2022.04

ISSN  0021-437X

The cut-off values of vitamin D deficiency in early infancy.

Ikeda K, Hara-Isono K, Takahashi K, Arimitsu T, Sato Y

Pediatrics and neonatology  2022.03

ISSN  1875-9572

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ファーマコメトリクス解析による医療個別化の推進　臨床試験個別データの精密解析に基づく慢性心不全患者に対する運動トレーニングの効果予測スコアの開発

吉岡 英樹, 副島 裕佳子, 畔 さゆり, 佐藤 洋美, 畠山 浩人, 佐藤 泰憲, 藤本 喜英, 安西 尚彦, 樋坂 章博

日本薬学会年会要旨集 ((公社)日本薬学会)  142年会   S04 - 2 2022.03

ISSN  0918-9823

The effect of the E484K mutation of SARS-CoV-2 on the neutralizing activity of antibodies from BNT162b2 vaccinated individuals.

Uwamino Y, Yokoyama T, Shimura T, Nishimura T, Sato Y, Wakui M, Kosaki K, Hasegawa N, Murata M

Vaccine  2022.02

ISSN  0264-410X

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False lumen being larger than true lumen is associated with late aortic events in uncomplicated type B aortic dissection.

Matsushita A, Tabata M, Hattori T, Mihara W, Sato Y

Interactive cardiovascular and thoracic surgery  2022.02

ISSN  1569-9293

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Evaluation of the effect of tofogliflozin on the tissue characteristics of the carotid wall-a sub-analysis of the UTOPIA trial.

Katakami N, Mita T, Maeda N, Sato Y, Watada H, Shimomura I, UTOPIA Study Investigators.

Cardiovascular diabetology 21 ( 1 ) 19 2022.02

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WJOG13219G: Triplet versus doublet in patients with previously untreated BRAF(V600E)-mutant metastatic colorectal cancer: A multi-institutional real-world data analysis (BRACELET study)

Shimozaki Keitaro, Hirata Kenro, Sato Tarou, Nakamura Maho, Kato Kyoko, Hirano Hidekazu, Kumekawa Yosuke, Hino Kaori, Kawakami Kentaro, Kito Yosuke, Matsumoto Toshihiko, Kawakami Takeshi, Komoda Masato, Nagashima Kengo, Sato Yasunori, Yamazaki Kentaro, Hironaka Shuichi, Hamamoto Yasuo, Takaishi Hiromasa, Muro Kei

JOURNAL OF CLINICAL ONCOLOGY 40 ( 4 )  2022.02

ISSN  0732-183X

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【現代の臨床研究のための統計学2022-洗練された研究デザインと統計解析を理解してみよう】方法論の近年の発展　アダプティブデザインの基礎　実例とともに

長島 健悟, 佐藤 泰憲

医学のあゆみ (医歯薬出版(株))  280 ( 5 ) 442 - 450 2022.01

ISSN  0039-2359

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アダプティブデザインとは、「試験中で蓄積しているデータを用いて、妥当性と完全性を損なうことなく、実施中の試験のひとつ以上の特性を修正する機会を事前に計画に盛り込んだ臨床試験デザイン」と定義されている。アダプティブデザインによって、従来の固定デザインよりも安全で有効な治療をより早く提供できるようになることが期待されており、近年注目が集まっている。また、2020年6月にはランダム化比較試験の報告のためのガイドラインであるCONSORTのアダプティブデザイン拡張版が出版されており、アダプティブデザイン用のチェックリストが提供されている。本稿では、アダプティブデザインの基礎について実例を交えて解説する。(著者抄録)

Topiroxostat versus allopurinol in patients with chronic heart failure complicated by hyperuricemia: A prospective, randomized, open-label, blinded-end-point clinical trial.

Sakuma M, Toyoda S, Arikawa T, Koyabu Y, Kato T, Adachi T, Suwa H, Narita JI, Anraku K, Ishimura K, Yamauchi F, Sato Y, Inoue T

PloS one 17 ( 1 ) e0261445 2022

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Efficacy of Early Closed Toe Amputation for Toe Ulcers with Suspected Osteomyelitis after Revascularization for Chronic Limb-Threatening Ischemia

Shintani Tsunehiro, Suzuki Sachi, Kikuchi Naoya, Ariya Takumi, Natsume Kayoko, Ookura Kazuhiro, Okui Jun, Sato Yasunori, Obara Hideaki

Annals of Vascular Diseases (The Editorial Committee of Annals of Vascular Diseases)  advpub ( 0 )  2022

ISSN  1881641X

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SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic individuals and a questionnaire survey in Japan.

Oba J, Taniguchi H, Sato M, Takanashi M, Yokemura M, Sato Y, Nishihara H

PloS one 17 ( 5 ) e0263700 2022

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Systematic Analysis of Clinical Trial Data for Personalized Therapy: Effects of Exercise Training in Chronic Heart Failure Patients Depend on Medications and Conditions

SOEJIMA Yukako, YOSHIOKA Hideki, SATO Hiromi, GURO Sayuri, HATAKEYAMA Hiroto, SATO Yasunori, FUJIMOTO Yoshihide, ANZAI Naohiko, HISAKA Akihiro

Annual Meeting of the Japanese Society of Toxicology (The Japanese Society of Toxicology)  49.1 ( 0 ) S13-4 2022

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<p>Although results of clinical trials are thoroughly analyzed to define benefits of the treatment, but are not fully analyzed to extract interindividual differences to achieve precise medicine. We are analyzing individual patient data from previous clinical studies for this purpose utilizing clinical trial disclosure systems. Exercise therapy is generally recommended as an adjunctive treatment in chronic heart failure. However, interindividual differences in benefit of exercise mostly have not been analyzed. In this study, we obtained patient data on the HF-ACTION study (2331 subjects) from the National Heart, Lung, and Blood Institute. With regard to clinical endpoints such as all-caused mortality (AD), significant interactions with the exercise effect were analyzed including patient backgrounds and medications (renin-angiotensin system inhibitors [RASIs] and beta-blockers [BBs]) with multivariate Cox regression models, and the selected covariates were validated by bootstrapping. Based on the results, SEEM score was constructed to judge exercise suitability. </p><p>It was revealed that exercise reduced AD in patients taking both BB and RASI with a hazard ratio (HR) of 0.86, but increased in patients not taking BB with a HR of 4.58. The exercise effect on AD was also influenced by pulse pressure, hemoglobin, ECG status, BMI, and history of stroke, thus SEEM score was constructed including these factors. AD was expected to be reduced with HR 0.54 when exercise therapy was selected according SEEM, compared to the opposite selection (95% CI, 0.44-0.68). Although this study is a post-hoc and should be interpreted with caution, exercise therapy in heart failure patients should be carefully selected, taking into account the patient background. The analysis of data from clinical trial disclosure system was of great significance to improve precise medicine.</p>

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MOG抗体関連疾患の疫学と臨床像

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 中島 一郎

Neurological Therapeutics (Japanese Society of Neurological Therapeutics)  39 ( 6 ) S196 - S196 2022

ISSN  09168443

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Effect of Personality Traits on Sustained Remission Among Patients with Major Depression: A 12-Month Prospective Study.

Waka Nogami, Atsuo Nakagawa, Nariko Katayama, Yuka Kudo, Mizuki Amano, Sakae Ihara, Chika Kurata, Yuki Kobayashi, Yohei Sasaki, Natsumi Ishikawa, Yasunori Sato, Masaru Mimura

Neuropsychiatric disease and treatment (Informa UK Limited)  18   2771 - 2781 2022

ISSN  1176-6328

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PURPOSE: Major depression is a heterogeneous disorder. Therefore, careful evaluation and comprehensive assessment are crucial elements for achieving remission. Personality traits influence prognosis and treatment outcomes, but there is not enough evidence on the association between personality traits and sustained remission (SR). Hence, the present study aimed to evaluate the relationship between personality traits and SR among patients with major depression. PATIENTS AND METHODS: The 12-month prospective study evaluated 77 patients diagnosed with major depressive disorder. All patients underwent a comprehensive assessment, including the Temperament and Personality Questionnaire (T&P) at baseline, and depression severity was measured at baseline as well as six and 12 months. SR was defined as remission (the GRID-Hamilton Depression Rating Scale [GRID-HAMD17] score ≦ 7) at both the 6- and 12-month follow-up. We compared eight T&P construct scores at baseline between the SR and non-SR groups. Multivariable logistic regression analyses were performed to determine the T&P personality traits related to SR. RESULTS: Patients who achieved SR had a lower T&P personal reserve and lower T&P rejection sensitivity. Further, lower scores on the T&P personal reserve trait were independently associated with higher rates of SR among patients with major depression. Patients who achieved SR had a shorter duration of the current depressive episode and milder severity of depression at baseline. CONCLUSION: A lower level of personal reserve predicted a higher probability of SR in the treatment of depression. Extended observations in naturalistic follow-up settings with larger sample sizes are required to better understand the personality traits affecting SR in patients with depression.

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Imatinib mesylate in combination with pembrolizumab in patients with advanced KIT-mutant melanoma following progression on standard therapy: A phase I/II trial and study protocol.

Hirai I, Tanese K, Fukuda K, Fusumae T, Nakamura Y, Sato Y, Amagai M, Funakoshi T

Medicine 100 ( 49 ) e27832 2021.12

ISSN  0025-7974

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Hyperferritinemia Is a Predictor of Onset of Diabetes in Japanese Males Independently of Decreased Renal Function and Fatty Liver: A Fifteen-Year Follow-Up Study.

Sakuma Y, Ogino J, Iwai R, Inoue T, Takahashi H, Suzuki Y, Kinoshita D, Takemura K, Takahashi H, Shimura H, Sato Y, Yoshida S, Hashimoto N

Journal of clinical medicine research 13 ( 12 ) 541 - 548 2021.12

ISSN  1918-3003

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Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol.

Nakagawara K, Namkoong H, Terai H, Masaki K, Tanosaki T, Shimamoto K, Lee H, Tanaka H, Okamori S, Kabata H, Chubachi S, Ikemura S, Kamata H, Yasuda H, Kawada I, Ishii M, Ishibashi Y, Harada S, Fujita T, Ito D, Bun S, Tabuchi H, Kanzaki S, Shimizu E, Fukuda K, Yamagami J, Kobayashi K, Hirano T, Inoue T, Kagyo J, Shiomi T, Ohgino K, Sayama K, Otsuka K, Miyao N, Odani T, Oyamada Y, Masuzawa K, Nakayama S, Suzuki Y, Baba R, Nakachi I, Kuwahara N, Ishiguro T, Mashimo S, Minematsu N, Ueda S, Manabe T, Funatsu Y, Koh H, Yoshiyama T, Saito F, Ishioka K, Takahashi S, Nakamura M, Goto A, Harada N, Kusaka Y, Nakano Y, Nishio K, Tateno H, Edahiro R, Takeda Y, Kumanogoh A, Kodama N, Okamoto M, Umeda A, Hagimura K, Sato T, Miyazaki N, Takemura R, Sato Y, Takebayashi T, Nakahara J, Mimura M, Ogawa K, Shimmura S, Negishi K, Tsubota K, Amagai M, Goto R, Ibuka Y, Hasegawa N, Kitagawa Y, Kanai T, Fukunaga K

BMJ open respiratory research 8 ( 1 )  2021.11

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ALSに対するロピニロール塩酸塩に関するランダム化臨床試験の結果(ROPALS)(Results Of A Randomized Clinical Trial of Ropinirole Hydrochloride For ALS(ROPALS))

高橋 愼一, 森本 悟, 伊東 大介, 伊達 悠岳, 岡田 健佑, Chai Muh Chyi, 西山 亜由美, 鈴木 直輝, 平井 美和, 加部 泰明, 末松 誠, 陣崎 雅弘, 青木 正志, 佐藤 泰憲, 中原 仁, 鈴木 則宏, 岡野 栄之

脳循環代謝 ((一社)日本脳循環代謝学会)  33 ( 1 ) 129 - 129 2021.11

ISSN  0915-9401

Effectiveness of mindfulness-based cognitive therapy follow-up programs for pharmacotherapy refractory anxiety disorders: a study protocol for a randomized controlled feasibility trial.

Sado M, Ninomiya A, Nagaoka M, Koreki A, Goto N, Sasaki Y, Takamori C, Kosugi T, Yamada M, Park S, Sato Y, Fujisawa D, Nakagawa A, Mimura M

JMIR research protocols  2021.10

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Japanese project for telepsychiatry evaluation during COVID-19: Treatment comparison trial (J-PROTECT): Rationale, design, and methodology.

Kishimoto T, Kinoshita S, Bun S, Sato Y, Kitazawa M, Kikuchi T, Sado M, Takamiya A, Mimura M, Nakamae T, Abe Y, Kanazawa T, Kawabata Y, Tomita H, Abe K, Hishimoto A, Asami T, Suda A, Watanabe Y, Amagai T, Sakuma K, Kida H, Funayama M, Kimura H, Sato A, Fujiwara S, Nagao K, Sugiyama N, Takamiya M, Kodama H, Azekawa T, J-PROTECT Collaborators.

Contemporary clinical trials    106596 2021.10

ISSN  1551-7144

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SRS Results for Lung Cancer Patients: A Retrospective Comparison of 10-19 vs ≧20 Brain Metastases(和訳中)

山本 昌昭, 芹澤 徹, 佐藤 泰憲

肺癌 ((NPO)日本肺癌学会)  61 ( 6 ) 569 - 569 2021.10

ISSN  0386-9628

iPS細胞創薬に基づいた筋萎縮性側索硬化症(ALS)に対するロピニロール塩酸塩の医師主導治験(ROPALS試験)

森本 悟, 高橋 愼一, 伊東 大介, 伊達 悠岳, 岡田 健佑, Chai Muh Chyi, 西山 亜由美, 鈴木 直輝, 平井 美和, 加部 泰明, 末松 誠, 陣崎 雅弘, 青木 正志, 佐藤 泰憲, 中原 仁, 鈴木 則宏, 岡野 栄之

神経治療学 ((一社)日本神経治療学会)  38 ( 6 ) S261 - S261 2021.10

ISSN  0916-8443

Longitudinal Assessment of Prognostic Understanding in Advanced Lung Cancer Patients and Its Association with Their Psychological Distress.

Arai D, Sato T, Nakachi I, Fujisawa D, Takeuchi M, Sato Y, Kawada I, Yasuda H, Ikemura S, Terai H, Nukaga S, Inoue T, Nakamura M, Oyamada Y, Terashima T, Sayama K, Saito F, Sakamaki F, Naoki K, Fukunaga K, Soejima K

The oncologist  2021.09

ISSN  1083-7159

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Best pre-ductal PaO₂ prior to extracorporeal membrane oxygenation as predictor of mortality in patients with congenital diaphragmatic hernia: a retrospective analysis of a Japanese database.

Terui K, Furukawa T, Nagata K, Hayakawa M, Okuyama H, Amari S, Yokoi A, Masumoto K, Yamoto M, Okazaki T, Inamura N, Toyoshima K, Uchida K, Okawada M, Sato Y, Usui N

Pediatric surgery international  2021.09

ISSN  0179-0358

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Cost-effectiveness analyses of augmented cognitive behavioral therapy for pharmacotherapy-resistant depression at secondary mental health care settings.

Sado M, Koreki A, Ninomiya A, Kurata C, Mitsuda D, Sato Y, Kikuchi T, Fujisawa D, Ono Y, Mimura M, Nakagawa A

Psychiatry and clinical neurosciences  2021.08

ISSN  1323-1316

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Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model.

Hatou S, Sayano T, Higa K, Inagaki E, Okano Y, Sato Y, Okano H, Tsubota K, Shimmura S

Stem cell research 55   102497 2021.08

ISSN  1873-5061

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The Influence of Tofogliflozin on Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus.

Katakami N, Mita T, Yoshii H, Shiraiwa T, Yasuda T, Okada Y, Torimoto K, Umayahara Y, Kaneto H, Osonoi T, Yamamoto T, Kuribayashi N, Maeda K, Yokoyama H, Kosugi K, Ohtoshi K, Hayashi I, Sumitani S, Tsugawa M, Ryomoto K, Taki H, Nakamura T, Kawashima S, Sato Y, Watada H, Shimomura I, UTOPIA study investigators.

Diabetes therapy : research, treatment and education of diabetes and related disorders  2021.08

ISSN  1869-6953

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Recovery of lower oesophageal barrier function: a pilot study comparing a mixture of atropine and neostigmine and sugammadex: A randomised controlled pilot study.

Suganuma E, Ishikawa T, Kitamura Y, Hayashida T, Matsumura T, Fujie M, Nozaki-Taguchi N, Sato Y, Isono S

European journal of anaesthesiology 38 ( 8 ) 856 - 864 2021.08

ISSN  0265-0215

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Hypercapnia versus normocapnia for emergence from desflurane anaesthesia: Single-blinded randomised controlled study.

Shinohara A, Nozaki-Taguchi N, Yoshimura A, Hasegawa M, Saito K, Okazaki J, Kitamura Y, Sato Y, Isono S

European journal of anaesthesiology  2021.07

ISSN  0265-0215

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Predictors and moderators of outcomes in mindfulness-based cognitive therapy intervention for early breast cancer patients.

Tamura N, Park S, Sato Y, Sato Y, Takita Y, Ninomiya A, Sado M, Mimura M, Fujisawa D

Palliative & supportive care    1 - 8 2021.06

ISSN  1478-9515

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Longitudinal validity and prognostic significance of the St George's Respiratory Questionnaire in Mycobacterium avium complex pulmonary disease.

Ogawa T, Asakura T, Suzuki S, Okamori S, Kusumoto T, Sato Y, Namkoong H, Kamata H, Ishii M, Fukunaga K, Hasegawa N

Respiratory medicine 185   106515 2021.06

ISSN  0954-6111

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Prediction of Causative Genes in Inherited Retinal Disorders from Fundus photography and Fundus Autofluorescence Imaging Utilising Deep Learning Techniques

Fujinami-Yokokawa Yu, Ninomiya Hideki, Liu Xiao, Yang Lizhu, Pontikos Nikolas, Yoshitake Kazutoshi, Iwata Takeshi, Sato Yasunori, Hashimoto Takeshi, Miyata Hiroaki, Fujinami Kaoru

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 62 ( 8 )  2021.06

ISSN  0146-0404

COMPARISON OF PHARMACODYNAMICS OF METHOTREXATE AS METHOTREXATE-POLYGLUTAMATES CONCENTRATIONS IN RHEUMATOID ARTHRITIS; INTERIM DATA EVALUATION OF MIRACLE STUDY CONDUCTED IN JAPAN, KOREA AND TAIWAN

Tamai H., Kaneko Y., Kameda H., Kuwana M., Okano Y., Ishii T., Ikeda K., Taguchi H., Sato S., Miyamoto T., Hirata S., Yasuoka H., Kojima T., Park S. H., Shin K., Baek H. J., Lee Y. J., Choi I. A., Kim J., Hsu P. N., Kuo C. F., Huang C. M., Weng M. Y., Sung W. Y., Tsai W. C., Cheng T. T., Taninaga T., Mori M., Miyagishi H., Sato Y., Takeuchi T.

ANNALS OF THE RHEUMATIC DISEASES 80   1152 - 1153 2021.06

ISSN  0003-4967

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Association of visit-to-visit glycemic variability with risk of cardiovascular diseases in high-risk Japanese patients with type 2 diabetes: A subanalysis of the EMPATHY trial.

Sato M, Inaishi J, Saisho Y, Sato Y, Komuro I, Itoh H

Journal of diabetes investigation  2021.05

ISSN  2040-1116

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Factors associated with outcome of egg allergy 1 year after oral food challenge: A good baseline quality of life may be beneficial.

Hamada K, Nagao M, Imakiire R, Furuya K, Mizuno Y, Sato Y, Matsunaga M, Yamada S, Nogami K, Hoshi M, Kobori T, Kainuma K, Iijima K, Fujisawa T

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology  2021.05

ISSN  0905-6157

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Classroom-based cognitive behavioural therapy: a large-scale non-randomised controlled trial of the 'Journey of the Brave'.

Urao Y, Ohira I, Koshiba T, Ishikawa SI, Sato Y, Shimizu E

Child and adolescent psychiatry and mental health 15 ( 1 ) 21 2021.04

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Effects of opioids on respiration assessed by a contact-free unconstraint respiratory monitor with load cells under the bed in advanced cancer patients.

Hasegawa M, Nozaki-Taguchi N, Shono K, Mizuno Y, Takai H, Sato Y, Isono S

Journal of applied physiology (Bethesda, Md. : 1985)  2021.04

ISSN  8750-7587

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Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data.

Shimozaki K, Sukawa Y, Sato Y, Horie S, Chida A, Tsugaru K, Togasaki K, Kawasaki K, Hirata K, Hayashi H, Hamamoto Y, Kanai T

Future oncology (London, England)  2021.04

ISSN  1479-6694

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Prediction of causative genes in inherited retinal disorder from fundus photography and autofluorescence imaging using deep learning techniques.

Fujinami-Yokokawa Y, Ninomiya H, Liu X, Yang L, Pontikos N, Yoshitake K, Iwata T, Sato Y, Hashimoto T, Tsunoda K, Miyata H, Fujinami K, Japan Eye Genetics Study (JEGC) Group.

The British journal of ophthalmology  2021.04

ISSN  0007-1161

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The Combination of Disease Duration to Age at Diagnosis and Hemoglobin A1c to Serum C-Peptide Reactivity Ratios Predicts Patient Response to Glucose-lowering Medication in Type 2 Diabetes: A Retrospective Cohort Study Across Japan (JDDM59).

Kanatsuka A, Sato Y, Higashi Y, Goto Y, Kawai K, Maegawa H, Japan Diabetes Data Management Study Group (JDDM).

Journal of diabetes investigation  2021.04

ISSN  2040-1116

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Clinical Features and Prognosis of Nontuberculous Mycobacterial Pleuritis: A Multicenter Retrospective Study.

Yagi K, Ito A, Fujiwara K, Morino E, Hase I, Nakano Y, Asakura T, Furuuchi K, Morita A, Asami T, Namkoong H, Saito F, Morimoto K, Ishii M, Sato Y, Tateno H, Nishio K, Oyamada Y, Fukunaga K, Sugiyama H, Ishida T, Kurashima A, Hasegawa N, Nontuberculous mycobacteriosis and bronchiectasis- Japan Research Consortium (NTM-JRC) .

Annals of the American Thoracic Society  2021.04

ISSN  2329-6933

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Smart Eye Camera: A Validation Study for Evaluating the Tear Film Breakup Time in Human Subjects.

Shimizu E, Yazu H, Aketa N, Yokoiwa R, Sato S, Katayama T, Hanyuda A, Sato Y, Ogawa Y, Tsubota K

Translational vision science & technology 10 ( 4 ) 28 2021.04

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ASSOCIATION OF CHILDHOOD PHYSICAL EXAMINATION AND LABORATORY PARAMETERS WITH HIGH BLOOD PRESSURE IN JAPANESE YOUNG ADULTS

Azegami Tatsuhiko, Uchida Keiko, Arima Fujiyo, Sato Yasunori, Awazu Midori, Inokuchi Mikako, Takeda Ayano, Itoh Hiroshi, Tokumura Mitsuaki, Mori Masaaki

JOURNAL OF HYPERTENSION 39   E41 - E41 2021.04

ISSN  0263-6352

Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study.

Sato T, Fujisawa D, Arai D, Nakachi I, Takeuchi M, Nukaga S, Kobayashi K, Ikemura S, Terai H, Yasuda H, Kawada I, Sato Y, Satomi R, Takahashi S, Hashiguchi MH, Nakamura M, Oyamada Y, Terashima T, Sayama K, Saito F, Sakamaki F, Inoue T, Naoki K, Fukunaga K, Soejima K

Palliative medicine    2692163211001721 2021.03

ISSN  0269-2163

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Clinical Observation of Allergic Conjunctival Diseases with Portable and Recordable Slit-Lamp Device.

Yazu H, Shimizu E, Sato S, Aketa N, Katayama T, Yokoiwa R, Sato Y, Fukagawa K, Ogawa Y, Tsubota K, Fujishima H

Diagnostics (Basel, Switzerland) 11 ( 3 )  2021.03

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Thrombus Formation at Stump of Pulmonary Vein after Pulmonary Lobectomy: A Prospective Multi-institutional Study

Yamamoto T., Tanaka K., Sakairi Y., Wada H., Suzuki H., Nakajima T., Iwata T., Iizasa T., Tagawa T., Yoshida S., Takemura R., Sato Y., Yoshino I.

JOURNAL OF THORACIC ONCOLOGY 16 ( 3 ) S262 - S262 2021.03

ISSN  1556-0864

A Study Validating the Estimation of Anterior Chamber Depth and Iridocorneal Angle with Portable and Non-Portable Slit-Lamp Microscopy.

Shimizu E, Yazu H, Aketa N, Yokoiwa R, Sato S, Yajima J, Katayama T, Sato R, Tanji M, Sato Y, Ogawa Y, Tsubota K

Sensors (Basel, Switzerland) (Sensors)  21 ( 4 ) 1 - 11 2021.02

ISSN  14248220

　View Summary

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This study assessed the anterior chamber depth (ACD) and iridocorneal angle using a portable smart eye camera (SEC) compared to the conventional slit-lamp microscope and anterior-segment optical coherence tomography (AS-OCT). This retrospective case-control study included 170 eyes from 85 Japanese patients. The correlation between the ACD evaluations conducted with the SEC and conventional slit-lamp was high (r = 0.814). The correlation between the Van-Herick Plus grade obtained using two devices was also high (r = 0.919). A high kappa value was observed for the Van-Herick Plus grading (Kappa = 0.757). A moderate correlation was observed between the ACD measured using AS-OCT and the slit-lamp image acquired with the conventional slit-lamp microscope and SEC (r = 0.609 and 0.641). A strong correlation was observed between the trabecular-iris angle (TIA) measured using AS-OCT and Van-Herick Plus grade obtained with the conventional slit-lamp microscope and SEC (r = 0.702 and 0.764). Strong correlations of ACD evaluation and high kappa value of the Van-Herick Plus grading indicated the adequate subjective assessment function of the SEC. Moderate correlations between the ACD objective measurement and evaluation and strong correlation between the TIA and Van-Herick Plus grade suggested the good objective assessment function of the SEC. The SEC demonstrated adequate performance for ACD evaluation and angle estimation.

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Long-term outcomes of 0.1% tacrolimus eye drops in eyes with severe allergic conjunctival diseases.

Yazu H, Fukagawa K, Shimizu E, Sato Y, Fujishima H

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 17 ( 1 ) 11 2021.02

ISSN  1710-1484

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Decreased physical activity in patients with ankle osteoarthritis. A case-control study comparing daily step counts.

Kimura S, Yamaguchi S, Ono Y, Matsuura Y, Sato Y, Akagi R, Sasho T, Ohtori S

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons  2021.02

ISSN  1268-7731

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Comparison of 2-year outcomes between primary and secondary prophylactic use of defibrillators in patients with coronary artery disease: A prospective propensity score-matched analysis from the Nippon Storm Study.

Kondo Y, Noda T, Sato Y, Ueda M, Nitta T, Aizawa Y, Ohe T, Kurita T

Heart rhythm O2 2 ( 1 ) 5 - 11 2021.02

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Association of childhood anthropometric measurements and laboratory parameters with high blood pressure in young adults.

Azegami T, Uchida K, Arima F, Sato Y, Awazu M, Inokuchi M, Murai-Takeda A, Itoh H, Tokumura M, Mori M

Hypertension research : official journal of the Japanese Society of Hypertension  2021.01

ISSN  0916-9636

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Comparison of Patient-Led and Physician-Led Insulin Titration in Japanese Type 2 Diabetes Mellitus Patients Based on Treatment Distress, Satisfaction, and Self-Efficacy: The COMMIT-Patient Study.

Ishii H, Nakajima H, Kamei N, Uchida D, Suzuki D, Ono Y, Sato Y, Shimono D

Diabetes therapy : research, treatment and education of diabetes and related disorders  2021.01

ISSN  1869-6953

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Effect of tofogliflozin on arterial stiffness in patients with type 2 diabetes: prespecified sub-analysis of the prospective, randomized, open-label, parallel-group comparative UTOPIA trial.

Katakami N, Mita T, Yoshii H, Shiraiwa T, Yasuda T, Okada Y, Torimoto K, Umayahara Y, Kaneto H, Osonoi T, Yamamoto T, Kuribayashi N, Maeda K, Yokoyama H, Kosugi K, Ohtoshi K, Hayashi I, Sumitani S, Tsugawa M, Ryomoto K, Taki H, Nakamura T, Kawashima S, Sato Y, Watada H, Shimomura I, UTOPIA study investigators.

Cardiovascular diabetology (Cardiovascular Diabetology)  20 ( 1 ) 4 2021.01

　View Summary

© 2021, The Author(s). Background: Tofogliflozin, an SGLT2 inhibitor, is associated with favorable metabolic effects, including improved glycemic control and serum lipid profile and decreased body weight, visceral adipose tissue, and blood pressure (BP). This study evaluated the effects of tofogliflozin on the brachial-ankle pulse wave velocity (baPWV) in patients with type 2 diabetes (T2DM) without a history of apparent cardiovascular disease. Methods: The using tofogliflozin for possible better intervention against atherosclerosis for type 2 diabetes patients (UTOPIA) trial is a prospective, randomized, open-label, multicenter, parallel-group, comparative study. As one of the prespecified secondary outcomes, changes in baPWV over 104 weeks were evaluated in 154 individuals (80 in the tofogliflozin group and 74 in the conventional treatment group) who completed baPWV measurement at baseline. Results: In a mixed-effects model, the progression in the right, left, and mean baPWV over 104 weeks was significantly attenuated with tofogliflozin compared to that with conventional treatment (– 109.3 [– 184.3, – 34.3] (mean change [95% CI] cm/s, p = 0.005; – 98.3 [– 172.6, – 24.1] cm/s, p = 0.010; – 104.7 [– 177.0, – 32.4] cm/s, p = 0.005, respectively). Similar findings were obtained even after adjusting the mixed-effects models for traditional cardiovascular risk factors, including body mass index (BMI), glycated hemoglobin (HbA1c), total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglyceride, systolic blood pressure (SBP), hypertension, smoking, and/or administration of drugs, including hypoglycemic agents, antihypertensive agents, statins, and anti-platelets, at baseline. The findings of the analysis of covariance (ANCOVA) models, which included the treatment group, baseline baPWV, and traditional cardiovascular risk factors, resembled those generated by the mixed-effects models. Conclusions: Tofogliflozin significantly inhibited the increased baPWV in patients with T2DM without a history of apparent cardiovascular disease, suggesting that tofogliflozin suppressed the progression of arterial stiffness. Trial Registration UMIN000017607. Registered 18 May 2015. (https://www.umin.ac.jp/icdr/index.html)

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Agreement Between Predictive, Allergen-Specific IgE Values Assessed by ImmunoCAP and IMMULITE 2000 3gAllergy™ Assay Systems for Milk and Wheat Allergies.

Al Hawi Y, Nagao M, Furuya K, Sato Y, Ito S, Hori H, Hirayama M, Fujisawa T, IPAD3g investigators.

Allergy, asthma & immunology research 13 ( 1 ) 141 - 153 2021.01

ISSN  2092-7355

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A safe delivery system to prevent COVID-19 transmission without negative-pressure isolation delivery rooms: Experience from a hospital with nosocomial outbreak

Kasuga Yoshifumi, Ochiai Daigo, Tamagawa Masumi, Oishi Maki, Endo Toyohide, Sato Yu, Iida Miho, Ikenoue Satoru, Tanaka Mamoru

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY 60 ( 1 ) 183 - 184 2021.01

ISSN  1028-4559

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What are the causes for low birthweight in Japan? A single hospital-based study.

Kasuga Y, Ikenoue S, Tamagawa M, Oishi M, Endo T, Sato Y, Iida M, Sato Y, Tanaka M, Ochiai D

PloS one 16 ( 6 ) e0253719 2021

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Stereotactic Radiosurgery Results for Patients With Brain Metastases From Gastrointestinal Cancer: A Retrospective Cohort Study of 802 Patients With GI-GPA Validity Test

Yamamoto Masaaki, Serizawa Toru, Sato Yasunori, Higuchi Yoshinori, Kawabe Takuya, Kasuya Hidetoshi, Barfod Bierta E.

ADVANCES IN RADIATION ONCOLOGY 6 ( 6 )  2021

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Sample size calculations for single-arm survival studies using transformations of the Kaplan-Meier estimator.

Nagashima K, Noma H, Sato Y, Gosho M

Pharmaceutical statistics  2020.12

ISSN  1539-1604

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1-year estimated glomerular filtration rate decline as risk factor of cardiovascular and renal endpoint in high-risk Japanese patients.

Meguro S, Inaishi J, Sato Y, Komuro I, Itoh H

Journal of diabetes investigation  2020.12

ISSN  2040-1116

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Proposal of a New Risk Score for Hospital Death Due to Acute Coronary Syndrome Developed by Machine Learning

Yoshioka Hideki, Hisaka Akihiro, Sato Yasunori

CIRCULATION RESEARCH 127 ( 12 ) E281 - E281 2020.12

ISSN  0009-7330

Weight gain velocity and adequate amount of nutrition for infants with congenital diaphragmatic hernia.

Terui K, Tazuke Y, Nagata K, Ito M, Okuyama H, Hayakawa M, Taguchi T, Sato Y, Usui N

Pediatric surgery international  2020.11

ISSN  0179-0358

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A graded prognostic model for patients surviving 3 years or more (GPM≥3Ys) after stereotactic radiosurgery for brain metastasis.

Sato Y, Yamamoto M, Serizawa T, Yamada KI, Higuchi Y, Kasuya H

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology  2020.11

ISSN  0167-8140

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Stereotactic Radiosurgery Results for Patients with 5-10 versus 11-20 Brain Metastases: A Retrospective Cohort Study Combining Two Databases Totaling 2319 Patients.

Yamamoto M, Serizawa T, Sato Y, Higuchi Y, Kasuya H

World neurosurgery  2020.11

ISSN  1878-8750

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High-dose statin therapy and the risk of haemorrhagic stroke in Asian patients with stable coronary artery disease: insights from the REAL-CAD study

Takahashi M., Tsuchida K., Sato Y., Iimuro S., Kario K., Kimura T., Nagai R.

EUROPEAN HEART JOURNAL 41   1326 - 1326 2020.11

ISSN  0195-668X

Anti-PD-1 antibody therapy for epithelial skin malignancies: An investigator-initiated, open-label, single-arm, multicenter, phase II clinical trial (NMSC-PD1 Study).

Ishii M, Hirai I, Tanese K, Fusumae T, Nakamura Y, Fukuda K, Uchi H, Kabashima K, Otsuka A, Yokota K, Yamazaki N, Namikawa K, Fujimura T, Takenouchi T, Yamamoto Y, Nishiguchi M, Sato Y, Amagai M, Funakoshi T

Medicine 99 ( 44 ) e22913 2020.10

ISSN  0025-7974

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A multicenter non-randomized phase III study of sentinel node navigation surgery for early gastric cancer.

Kamiya S, Takeuchi H, Fukuda K, Kawakubo H, Takahashi N, Mitsumori N, Terashima M, Tsujimoto H, Kinami S, Natsugoe S, Ohi M, Kadoya S, Fushida S, Hayashi H, Nabeshima K, Sakamoto J, Matsuda S, Mayanagi S, Irino T, Sato Y, Kitagawa Y

Japanese journal of clinical oncology  2020.10

ISSN  0368-2811

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肺悪性腫瘍根治切除における肺静脈切離断端血栓形成および術後脳梗塞発症に関する多施設観察研究　中間解析報告

山本 高義, 鈴木 秀海, 田中 教久, 坂入 祐一, 和田 啓伸, 中島 崇裕, 岩田 剛和, 飯笹 俊彦, 田川 哲三, 吉田 成利, 竹村 亮, 佐藤 泰憲, 吉野 一郎

日本胸部外科学会定期学術集会 ((一社)日本胸部外科学会)  73回   LOO14 - 28 2020.10

Utility of the EULAR Sjögren syndrome disease activity index in Japanese children: a retrospective multicenter cohort study.

Iwata N, Tomiita M, Kobayashi I, Inoue Y, Nonaka Y, Okamoto N, Umebayashi H, Hara R, Ito Y, Sato Y, Mori M

Pediatric rheumatology online journal 18 ( 1 ) 73 2020.09

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Development of a High-Efficacy Reprogramming Method for Generating Human Induced Pluripotent Stem (iPS) Cells from Pathologic and Senescent Somatic Cells.

Tanaka N, Kato H, Tsuda H, Sato Y, Muramatsu T, Iguchi A, Nakajima H, Yoshitake A, Senbonmatsu T

International journal of molecular sciences (International Journal of Molecular Sciences)  21 ( 18 ) 1 - 16 2020.09

ISSN  16616596

　View Summary

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Induced pluripotent stem (iPS) cells are a type of artificial pluripotent stem cell induced by the epigenetic silencing of somatic cells by the Yamanaka factors. Advances in iPS cell reprogramming technology will allow aging or damaged cells to be replaced by a patient’s own rejuvenated cells. However, tissue that is senescent or pathologic has a relatively low reprogramming efficiency as compared with juvenile or robust tissue, resulting in incomplete reprogramming; iPS cells generated from such tissue types do not have sufficient differentiation ability and are therefore difficult to apply clinically. Here, we develop a new reprogramming method and examine it using myofibroblasts, which are pathologic somatic cells, from patient skin tissue and from each of the four heart chambers of a recipient heart in heart transplant surgery. By adjusting the type and amount of vectors containing transcriptional factors for iPS cell reprogramming, as well as adjusting the transfection load and culture medium, the efficiency of iPS cell induction from aged patient skin-derived fibroblasts was increased, and we successfully induced iPS cells from myocardial fibroblasts isolated from the pathologic heart of a heart transplant recipient.

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The Association of In-Hospital Transcatheter Aortic Valve Replacement Availability on Outcomes of Surgical Aortic Valve Replacement in Elderly Patients.

Tabata M, Kumamaru H, Ono A, Miyata H, Sato Y, Motomura N

Circulation journal : official journal of the Japanese Circulation Society (一般社団法人 日本循環器学会)  84 ( 9 ) 1599 - 1604 2020.08

ISSN  1346-9843

　View Summary

<p><b><i>Background:</i></b>Transcatheter aortic valve replacement (TAVR) has been performed more and more frequently in elderly patients with aortic stenosis. We investigated the association of in-hospital availability of TAVR on outcomes of surgical aortic valve replacement (SAVR) in the era of TAVR.</p><p><b><i>Methods and Results:</i></b>We utilized data from the Japan Adult Cardiovascular Surgery Database. Between October 2013 and December 2016, 9,330 patients aged ≥80 years underwent isolated SAVR or SAVR with coronary artery bypass grafting in 557 centers in Japan. We assessed the associations of in-hospital TAVR availability with operative mortality and composite complications adjusting for each patient's characteristics, JapanSCORE predicted the risk scores, and hospital volumes of SAVR using generalized estimation equation methods. Observed operative mortality rates were 3.4% in all centers, 2.0% in TAVR centers and 4.0% in non-TAVR centers. The multivariable analyses showed that TAVR centers had statistically significantly lower operative mortality compared with non-TAVR centers among all patients (odds ratio 0.60, 95% confidence interval 0.41–0.89, P=0.01) and among intermediate/high-risk patients (odds ratio 0.52, 95% confidence interval 0.32–0.85, P<0.01) but not among low-risk patients (odds ratio 0.82, 95% confidence interval 0.44–1.51, P=0.52).</p><p><b><i>Conclusions:</i></b>In-hospital TAVR availability was associated with better outcomes of SAVR among elderly patients. This association was statistically significant among intermediate/high-risk patients but not significant among low-risk patients.</p>

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Stereotactic radiosurgery for brain metastases: A retrospective cohort study comparing treatment results between two lung cancer patient age groups, 75 years or older vs 65-74 years.

Yamamoto M, Serizawa T, Sato Y, Higuchi Y, Kasuya H, Barfod BE

Lung cancer (Amsterdam, Netherlands) (Lung Cancer)  149   103 - 112 2020.08

ISSN  0169-5002

　View Summary

© 2020 Elsevier B.V. Background: There is little information on stereotactic radiosurgery (SRS) results for brain metastases (BMs) in lung cancer patients ≥75 years of age. We aimed to reappraise whether SRS results for patients ≥75 (very elderly) differ from those of patients with 65−74 years old (elderly). Methods: This IRB-approved retrospective cohort study was based on our prospectively-accumulated database including 7351 consecutive patients undergoing gamma knife (GK) SRS performed for BMs by two highly experienced neurosurgeons during the 1998–2018 period. We selected a total of 2915 elderly patients (age ≥65 years, 39.7 % of the 7351) with lung cancers (902 females, 2013 males, median age; 72 [maximum; 96] years, 2441 NSCLCs, 474 SCLCs) for this study. Results: Post-SRS median survival times (MSTs, months) differed significantly between the two lung cancer types, NSCLC (9.0) and SCLC (7.2, p < 0.0001). In NSCLC patients, post-SRS MSTs were significantly shorter in the very elderly (9.7) than those in the elderly (7.8) group (p < 0.0001). However, in SCLC patients, there were no significant MST differences (7.3 vs 6.9, p = 0.52) between the two age groups. In both NSCLC and SCLC patients, neither crude nor cumulative incidences of secondary endpoints in the very elderly group, i.e., neurological death, neurological deterioration, local recurrence, repeat SRS, salvage whole brain radiotherapy and SRS-related complications, were shown to be unfavorable to those in the elderly group. Conclusions: Our results suggest that carefully-selected patients ≥75 years of age are not poor candidates for SRS as compared to those 65−74 years old.

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Scores of Health-Related Quality of Life Questionnaire Worsen Consistently in Patients of COPD: Estimating Disease Progression over 30 Years by SReFT with Individual Data Collected in SUMMIT Trial.

Kawamatsu S, Jin R, Araki S, Yoshioka H, Sato H, Sato Y, Hisaka A

Journal of clinical medicine 9 ( 8 )  2020.08

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Evaluation of Nuclear Cataract with Smartphone-Attachable Slit-Lamp Device.

Yazu H, Shimizu E, Okuyama S, Katahira T, Aketa N, Yokoiwa R, Sato Y, Ogawa Y, Fujishima H

Diagnostics (Basel, Switzerland) 10 ( 8 )  2020.08

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Impact of breast cancer subtype on clinical outcomes after Gamma Knife radiosurgery for brain metastases from breast cancer: a multi-institutional retrospective study (JLGK1702).

Aoyagi K, Higuchi Y, Matsunaga S, Serizawa T, Yomo S, Aiyama H, Nagano O, Kondoh T, Kenai H, Shuto T, Kawagishi J, Jokura H, Sato S, Nakazaki K, Nakaya K, Hasegawa T, Kawashima M, Kawai H, Yamanaka K, Nagatomo Y, Yamamoto M, Sato Y, Aoyagi T, Matsutani T, Iwadate Y

Breast cancer research and treatment (Breast Cancer Research and Treatment)   2020.08

ISSN  0167-6806

　View Summary

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Introduction: Brain metastasis (BM) is one of the most important issues in the management of breast cancer (BC), since BMs are associated with neurological deficits. However, the importance of BC subtypes remains unclear for BM treated with Gamma Knife radiosurgery (GKS). Thus, we conducted a multicenter retrospective study to compare clinical outcomes based on BC subtypes, with the aim of developing an optimal treatment strategy. Methods: We studied 439 patients with breast cancer and 1–10 BM from 16 GKS facilities in Japan. Overall survival (OS) was analyzed by the Kaplan–Meier method, and cumulative incidences of systemic death (SD), neurologic death (ND), and tumor progression were estimated by competing risk analysis. Results: OS differed among subtypes. The median OS time (months) after GKS was 10.4 in triple-negative (TN), 13.7 in Luminal, 31.4 in HER2, and 35.8 in Luminal-HER2 subtype BC (p < 0.0001). On multivariate analysis, poor control of the primary disease (hazard ratio [HR] = 1.84, p < 0.0001), active extracranial disease (HR = 2.76, p < 0.0001), neurological symptoms (HR 1.44, p = 0.01), and HER2 negativity (HR = 2.66, p < 0.0001) were significantly associated with worse OS. HER2 positivity was an independent risk factor for local recurrence (p = 0.03) but associated with lower rates of ND (p = 0.03). TN histology was associated with higher rates of distant brain failure (p = 0.03). Conclusions: HER2 positivity is related to the longer OS after SRS; however, we should pay attention to preventing recurrence in Luminal-HER2 patients. Also, TN patients require meticulous follow-up observation to detect distant metastases and/or LMD.

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Clinical risk model for predicting 1-year mortality after transcatheter aortic valve replacement.

Yamamoto M, Otsuka T, Shimura T, Yamaguchi R, Adachi Y, Kagase A, Tokuda T, Yashima F, Watanabe Y, Tada N, Naganuma T, Araki M, Yamanaka F, Mizutani K, Tabata M, Watanabe S, Sato Y, Ueno H, Takagi K, Higashimori A, Shirai S, Hayashida K

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions  2020.07

ISSN  1522-1946

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Tofogliflozin does not delay progression of carotid atherosclerosis in patients with type 2 diabetes: a prospective, randomized, open-label, parallel-group comparative study.

Katakami N, Mita T, Yoshii H, Shiraiwa T, Yasuda T, Okada Y, Torimoto K, Umayahara Y, Kaneto H, Osonoi T, Yamamoto T, Kuribayashi N, Maeda K, Yokoyama H, Kosugi K, Ohtoshi K, Hayashi I, Sumitani S, Tsugawa M, Ryomoto K, Taki H, Nakamura T, Kawashima S, Sato Y, Watada H, Shimomura I, UTOPIA study investigators.

Cardiovascular diabetology 19 ( 1 ) 110 2020.07

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<i>Staphylococcus</i> Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development.

Nakamura Y, Takahashi H, Takaya A, Inoue Y, Katayama Y, Kusuya Y, Shoji T, Takada S, Nakagawa S, Oguma R, Saito N, Ozawa N, Nakano T, Yamaide F, Dissanayake E, Suzuki S, Villaruz A, Varadarajan S, Matsumoto M, Kobayashi T, Kono M, Sato Y, Akiyama M, Otto M, Matsue H, Núñez G, Shimojo N

Science translational medicine 12 ( 551 )  2020.07

ISSN  1946-6234

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Inter-agency collaboration factors affecting multidisciplinary workers' ability to identify child maltreatment.

Okato A, Hashimoto T, Tanaka M, Saito N, Endo M, Okayama J, Ichihara A, Eshima S, Handa S, Senda M, Sato Y, Watanabe H, Nakazato M, Iyo M

BMC research notes 13 ( 1 ) 323 2020.07

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Effects of ipragliflozin versus metformin in combination with sitagliptin on bone and muscle in Japanese patients with type 2 diabetes mellitus: Sub-analysis of a prospective, randomized, controlled study (PRIME-V study).

Koshizaka M, Ishikawa K, Ryoichi I, Maezawa Y, Sakamoto K, Uchida D, Nakamura S, Yamaga M, Yokoh H, Kobayashi A, Onishi S, Kobayashi K, Ogino J, Hashimoto N, Tokuyama H, Shimada F, Ohara E, Ishikawa T, Shoji M, Ide S, Ide K, Baba Y, Hattori A, Kitamoto T, Horikoshi T, Shimofusa R, Takahashi S, Nagashima K, Sato Y, Takemoto M, Newby LK, Yokote K, PRIME-V study group.

Journal of diabetes investigation  2020.07

ISSN  2040-1116

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Genetic risks of schizophrenia identified in a matched case-control study.

Oishi K, Niitsu T, Kanahara N, Sato Y, Iwayama Y, Toyota T, Hashimoto T, Sasaki T, Takase M, Shiina A, Yoshikawa T, Iyo M

European archives of psychiatry and clinical neuroscience  2020.07

ISSN  0940-1334

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Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease.

Asakura T, Kimizuka Y, Nishimura T, Suzuki S, Namkoong H, Masugi Y, Sato Y, Ishii M, Hasegawa N

Respirology (Carlton, Vic.)  2020.06

ISSN  1323-7799

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Aqueous olanexidine versus aqueous povidone-iodine for surgical skin antisepsis on the incidence of surgical site infections after clean-contaminated surgery: a multicentre, prospective, blinded-endpoint, randomised controlled trial.

Obara H, Takeuchi M, Kawakubo H, Shinoda M, Okabayashi K, Hayashi K, Sekimoto Y, Maeda Y, Kondo T, Sato Y, Kitagawa Y

The Lancet. Infectious diseases  2020.06

ISSN  1473-3099

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Evaluation of First-line Radiosurgery vs Whole-Brain Radiotherapy for Small Cell Lung Cancer Brain Metastases: The FIRE-SCLC Cohort Study.

Rusthoven CG, Yamamoto M, Bernhardt D, Smith DE, Gao D, Serizawa T, Yomo S, Aiyama H, Higuchi Y, Shuto T, Akabane A, Sato Y, Niranjan A, Faramand AM, Lunsford LD, McInerney J, Tuanquin LC, Zacharia BE, Chiang V, Singh C, Yu JB, Braunstein S, Mathieu D, Touchette CJ, Lee CC, Yang HC, Aizer AA, Cagney DN, Chan MD, Kondziolka D, Bernstein K, Silverman JS, Grills IS, Siddiqui ZA, Yuan JC, Sheehan JP, Cordeiro D, Nosaki K, Seto T, Deibert CP, Verma V, Day S, Halasz LM, Warnick RE, Trifiletti DM, Palmer JD, Attia A, Li B, Cifarelli CP, Brown PD, Vargo JA, Combs S, Kessel KA, Rieken S, Patel S, Guckenberger M, Andratschke N, Kavanagh BD, Robin TP

JAMA oncology  2020.06

ISSN  2374-2437

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A comparative evaluation of cataract classification with the conventional slit-lamp examination and a portable medical device "Smart Eye Camera"

Yazu Hiroyuki, Okuyama Sho, Katahira Takuya, Shimizu Eisuke, Aketa Naohiko, Sato Yasunori, Ogawa Yoko, Fujishima Hiroshi

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 61 ( 7 )  2020.06

ISSN  0146-0404

A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4.

Fujioka M, Akiyama T, Hosoya M, Kikuchi K, Fujiki Y, Saito Y, Yoshihama K, Ozawa H, Tsukada K, Nishio SY, Usami SI, Matsunaga T, Hasegawa T, Sato Y, Ogawa K

Medicine 99 ( 19 ) e19763 2020.05

ISSN  0025-7974

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The effects of health education on health science teachers' intention to recommend adolescent HPV vaccine for female students in Japan.

Ishiwada N, Suzuki C, Hasebe S, Tsuchiya A, Takeuchi N, Hishiki H, Sato Y, Sugita K

Human vaccines & immunotherapeutics    1 - 6 2020.03

ISSN  2164-5515

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Midterm Results of a Japanese Prospective Multicenter Registry of Heparin-Bonded Expanded Polytetrafluoroethylene Grafts for Above-the-Knee Femoropopliteal Bypass.

Shibutani S, Obara H, Matsubara K, Toya N, Isogai N, Ogino H, Watada S, Asami A, Kudo T, Kanaoka Y, Fujimura N, Harada H, Uchiyama H, Sato Y, Ohki T, Japanese Bypass Registry Group, Tokyo, Japan.

Circulation journal : official journal of the Japanese Circulation Society  2020.02

ISSN  1346-9843

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Correction to: Low serum estradiol levels are related to Mycobacterium avium complex lung disease: a cross-sectional study.

Uwamino Y, Nishimura T, Sato Y, Tamizu E, Asakura T, Uno S, Mori M, Fujiwara H, Ishii M, Kawabe H, Murata M, Hasegawa N

BMC infectious diseases 20 ( 1 ) 131 2020.02

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Effects of Cardiac Surgery and Salvaged Blood Transfusion on Coagulation Function Assessed by Thromboelastometry.

Son K, Yamada T, Tarao K, Kitamura Y, Okazaki J, Sato Y, Isono S

Journal of cardiothoracic and vascular anesthesia  2020.02

ISSN  1053-0770

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Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis.

Kuroi Y, Ohbuchi H, Arai N, Takahashi Y, Hagiwara S, Sasahara A, Funaki A, Itoh T, Sato Y, Kasuya H

Journal of neurointerventional surgery  2020.02

ISSN  1759-8478

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Multicentre randomised controlled trial of balloon pulmonary angioplasty and riociguat in patients with chronic thromboembolic pulmonary hypertension: protocol for the MR BPA study.

Kawakami T, Matsubara H, Abe K, Kataoka M, Kohsaka S, Sato Y, Shinke T, Fukuda K

BMJ open 10 ( 2 ) e028831 2020.02

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Lenalidomide Treatment for Thalidomide-refractory POEMS Syndrome: A Prospective Single-arm Clinical Trial.

Suichi T, Misawa S, Nagashima K, Sato Y, Iwai Y, Katayama K, Sekiguchi Y, Shibuya K, Amino H, Suzuki YI, Tsuneyama A, Nakamura K, Kuwabara S

Internal medicine (Tokyo, Japan) (一般社団法人 日本内科学会)   2020.02

ISSN  0918-2918

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<p><b>Objective </b>A randomized controlled trial has shown the efficacy of thalidomide against Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome; however, there are still refractory patients. We studied the effects of lenalidomide, a derivative of thalidomide, on patients refractory to thalidomide. </p><p><b>Methods </b>This prospective single-arm trial evaluated the safety and efficacy of lenalidomide plus dexamethasone in refractory or recurrent patients with POEMS syndrome. The regimen was administered as six 28-day cycles with lenalidomide on days 1-21 (15 mg in cycle 1, and 25 mg in cycle 2-6) plus dexamethasone once a week (20 mg). The primary endpoints were the rate of reduction in the serum vascular endothelial growth factor (VEGF) level at 24 weeks and the incidence of adverse events. This trial was registered with ClinicalTrial.gov, NCT02193698. </p><p><b>Results </b>Between July 2014 and December 2015, five men were enrolled. All patients had been refractory to thalidomide plus dexamethasone for more than 24 weeks. The mean rate of reduction in the serum VEGF level at 24 weeks was 59.6%±8.3% (p=0.0003). The mean serum VEGF level decreased from 2,466±771 pg/mL to 974±340 pg/mL. No serious adverse events were observed, and all patients completed six cycles treatment. </p><p><b>Discussion </b>Lenalidomide is a therapeutic option for thalidomide-refractory patients with POEMS syndrome. </p>

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Three-institution study on applicability of initial brain metastasis velocity for breast cancer brain metastasis patients undergoing stereotactic radiosurgery.

Yamamoto M, Serizawa T, Nagano O, Aoyagi K, Higuchi Y, Sato Y, Kasuya H, Barfod BE

Journal of neuro-oncology  2020.01

ISSN  0167-594X

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Importance of Distal Sealing During Endovascular Aneurysm Repair Using Aneurysmal Common Iliac Artery as Landing Zone.

Shintani T, Mitsuoka H, Hasegawa Y, Hayashi M, Natsume K, Ookura K, Sato Y, Obara H

Annals of vascular surgery  2020.01

ISSN  0890-5096

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Sentinel node mapping for post-endoscopic resection gastric cancer: multicenter retrospective cohort study in Japan.

Mayanagi S, Takahashi N, Mitsumori N, Arigami T, Natsugoe S, Yaguchi Y, Suda T, Kinami S, Ohi M, Kawakubo H, Sato Y, Takeuchi H, Aikou T, Kitagawa Y, Japanese Society for Sentinel Node Navigation Surgery.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association  2020.01

ISSN  1436-3291

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多施設共同後ろ向き研究による乳癌脳転移に対するガンマナイフ後のサブタイプ別治療成績の実態調査(JLGK1702)

青柳 京子, 樋口 佳則, 松永 成生, 芹澤 徹, 四方 聖二, 相山 仁, 永野 修, 近藤 威, 祁内 博行, 周藤 高, 川岸 潤, 城倉 英史, 佐藤 園美, 中崎 清之, 中谷 幸太郎, 長谷川 俊典, 河島 真理子, 河合 秀哉, 山中 一浩, 長友 康, 山本 昌昭, 佐藤 泰憲, 青柳 智義, 松谷 智郎, 岩立 康男

定位的放射線治療 (日本定位放射線治療学会)  24   27 - 35 2020.01

ISSN  1342-9930

Epidemiology of hospitalised paediatric community-acquired pneumonia and bacterial pneumonia following the introduction of 13-valent pneumococcal conjugate vaccine in the national immunisation programme in Japan

Takeuchi N., Naito S., Ohkusu M., Abe K., Shizuno K., Takahashi Y., Omata Y., Nakazawa T., Takeshita K., Hishiki H., Hoshino T., Sato Y., Ishiwada N.

EPIDEMIOLOGY AND INFECTION 148 2020

ISSN  0950-2688

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A Cohort Study of Stereotactic Radiosurgery Results for Patients With 5 to 15 Versus 2 to 4 Brain Metastatic Tumors

Yamamoto M., Sato Y., Higuchi Y., Kasuya H., Barfod B.

Advances in Radiation Oncology (Advances in Radiation Oncology)   2020

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© 2019 The Author(s) Purpose: The role of stereotactic radiosurgery (SRS) alone for patients with ≥5 brain metastases is not fully understood. The objective of the study was to compare SRS-alone treatment results for 2 to 4 versus 5 to 15 tumors. Methods and Materials: This was an institutional review board–approved, retrospective cohort study using our prospectively accumulated database including 1150 patients with 2 to 4 tumors and 939 with 5 to 15 tumors who underwent Gamma Knife SRS during a 20-year period (1998-2018). The Kaplan-Meier method was used to determine post-SRS survival times, and competing risk analyses were applied to estimate cumulative incidences of the secondary endpoints. Results: The post-SRS median survival time was slightly longer in the group with 2 to 4 tumors (8.1 months) than in that with 5 to 15 tumors (7.2 months, P =.0010). Median survival time differences were statistically significant for non-small cell lung cancer, gastrointestinal tract cancer, and others but not for small cell lung cancer, breast cancer, and kidney cancer. Multivariable analysis demonstrated female sex, better Karnofsky Performance Status score, non-small cell lung cancer (vs gastrointestinal tract cancer), younger age, controlled primary cancer, and no extracerebral metastases to be significant predictors of a longer survival period in both tumor number groups. Crude and cumulative incidences of salvage whole brain radiation therapy were significantly higher in the group with 5 to 15 tumors than in that with 2 to 4 tumors, although those of other secondary endpoints were similar to or lower in the 5 to 15 tumor number group than those in the group with 2 to 4 tumors. Conclusions: We conclude that carefully selected patients with ≥5 to 15 tumors are not unfavorable candidates for SRS alone.

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Evaluation of the Japanese Version of the Cancer Survivors' Unmet Needs Scale

Komatsu Hiroko, Yagasaki Kaori, Sato Yasunori, Arao Harue, Yamamoto Sena, Hayashida Tetsu

ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING 7 ( 2 ) 167 - 173 2020

ISSN  2347-5625

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Patterns in Psychiatrists' Prescription of Valproate for Female Patients of Childbearing Age With Bipolar Disorder in Japan: A Questionnaire Survey.

Tachibana M, Hashimoto T, Tanaka M, Watanabe H, Sato Y, Takeuchi T, Terao T, Kimura S, Koyama A, Ebisawa S, Shizu Y, Nagase T, Hirakawa J, Hatta K, Nakazato M, Iyo M

Frontiers in psychiatry 11   250 2020

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Effect of Atheromatous Aorta on Thromboembolic Complications after Endovascular Aortic Aneurysm

Shintani Tsunehiro, Mitsuoka Hiroshi, Hasegawa Yuto, Hayashi Masanori, Natsume Kayoko, Ookura Kazuhiro, Sato Yasunori, Obara Hideaki

Annals of Vascular Diseases (Annals of Vascular Diseases 編集委員会)   2020

ISSN  1881-641X

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<p><b>Objective</b>: The purpose of this study was to evaluate the effect of atheromatous aorta on thromboembolic complications after endovascular aortic aneurysm repair (EVAR) and to assess the risk factors for these complications.</p><p><b>Materials and Methods</b>: This retrospective study included patients who underwent EVAR for an abdominal aortic aneurysm at the Shizuoka Red Cross Hospital from 2007 to 2018. We defined atheromatous aorta as a thoracic shaggy aorta or abdominal aorta with neck thrombus. The main outcome was renal dysfunction and peripheral embolization (thromboembolic complications). We compared the incidence of thromboembolic complications between patients with normal aorta and atheromatous aorta. Moreover, we assessed the risk factors associated with thromboembolic complications in patients with atheromatous aorta.</p><p><b>Results</b>: Patients with atheromatous aorta had significantly more thromboembolic complications, such as renal dysfunction (24.5% vs. 3.9%; P<0.001) and peripheral embolization (12.3% vs. 0.0%; P<0.001) than those with normal aorta, respectively. We identified no risk factors associated with thromboembolic complications in patients with atheromatous aorta.</p><p><b>Conclusion</b>: Atheromatous aorta increases the risk of thromboembolic complications after EVAR. However, there is no established therapy for these thromboembolic complications. Further studies are necessary to determine the appropriate therapy, including appropriate preoperative medication, to prevent these complications.</p>

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The distributions of hematologic and biochemical values in healthy high-school adolescents in Japan.

Azegami T, Nishimura T, Murai-Takeda A, Yamada-Goto N, Sato Y, Mori M

PloS one 15 ( 11 ) e0242272 2020

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Low serum estradiol levels are related to Mycobacterium avium complex lung disease: a cross-sectional study.

Uwamino Y, Nishimura T, Sato Y, Tamizu E, Asakura T, Uno S, Mori M, Fujiwara H, Ishii M, Kawabe H, Murata M, Hasegawa N

BMC infectious diseases 19 ( 1 ) 1055 2019.12

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Effects of prophylactic dexamethasone on postoperative nausea and vomiting in scoliosis correction surgery: a double-blind, randomized, placebo-controlled clinical trial

Wakamiya R., Seki H., Ideno S., Ihara N., Minoshima R., Watanabe K., Sato Y., Morisaki H.

Scientific Reports (Scientific Reports)  9 ( 1 )  2019.12

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© 2019, The Author(s). Dexamethasone is widely used for postoperative nausea and vomiting (PONV) prophylaxis, but its effect on PONV prevention in paediatric patients is validated only in short minor surgical procedures. In this study, we aimed to determine whether a single dose of dexamethasone reduces PONV in highly invasive surgeries that require opioid-based postoperative analgesia. One hundred adolescents undergoing scoliosis correction surgery were randomized to receive intravenous dexamethasone 0.15 mg/kg (dexamethasone group) or saline (control group) at induction of anaesthesia. The primary outcome was the incidence of PONV in the 72 h postoperatively. Data for 98 patients were available for analysis. The 72-h incidence of PONV was significantly lower in the dexamethasone group than in the control group (62.5% vs 84.0%; RR 0.74, 95% CI 0.58–0.96, P = 0.02). During the first and second 24-h postoperative intervals, fewer patients in the dexamethasone group received rescue antiemetics. Visual analogue scale scores for nausea and pain were lower in the dexamethasone group than in the control group during the first 24 h postoperatively. Dexamethasone did not increase the number of adverse events. The results of this study showed that a single dose of dexamethasone was effective for reducing PONV after paediatric scoliosis correction surgery.

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Quality and quantity of visceral fat tissue are associated with insulin resistance and survival outcomes after chemotherapy in patients with breast cancer.

Iwase T, Sangai T, Fujimoto H, Sawabe Y, Matsushita K, Nagashima K, Sato Y, Nakagawa A, Masuda T, Nagashima T, Ohtsuka M

Breast cancer research and treatment  2019.10

ISSN  0167-6806

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Changes in laryngeal airway patency in response to complete reversal of rocuronium-induced paralysis with sugammadex in small children with a supraglottic airway: protective effect of fentanyl?

Ishibashi K, Kitamura Y, Kato S, Sugano M, Sakaguchi Y, Sato Y, Isono S

British journal of anaesthesia  2019.10

ISSN  0007-0912

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Influence of foot position on the measurement of first metatarsal axial rotation using the first metatarsal axial radiographs.

Sadamasu A, Yamaguchi S, Kimura S, Ono Y, Sato Y, Akagi R, Sasho T, Ohtori S

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association  2019.10

ISSN  0949-2658

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Impact of Stent Graft Design on External Iliac Artery Limb Occlusion Rates After Endovascular Aneurysm Repair: Post-hoc Analysis of a Japanese Multicentre Database.

Shintani T, Obara H, Matsubara K, Hayashi K, Hayashi M, Ono S, Shimogawara T, Shibutani S, Watada S, Sekimoto Y, Uchida N, Asami A, Fujii T, Harada H, Fujimura N, Sato Y, Kitagawa Y

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery  2019.10

ISSN  1078-5884

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Novel Risk Score for Fetuses with Congenital Diaphragmatic Hernia Based on Ultrasound Findings.

Terui K, Nagata K, Hayakawa M, Okuyama H, Amari S, Yokoi A, Masumoto K, Urushihara N, Okazaki T, Inamura N, Toyoshima K, Uchida K, Furukawa T, Okawada M, Sato Y, Usui N

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie  2019.10

ISSN  0939-7248

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Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease.

Shimizu E, Aketa N, Yazu H, Uchino M, Kamoi M, Sato Y, Tsubota K, Ogawa Y

The ocular surface  2019.10

ISSN  1542-0124

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Showering is associated with Mycobacterium avium complex lung disease: An observational study in Japanese women.

Uwamino Y, Nishimura T, Sato Y, Tamizu E, Uno S, Mori M, Fujiwara H, Kawabe H, Murata M, Hasegawa N

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy  2019.10

ISSN  1341-321X

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The impact of EGFR-TKI use on clinical outcomes of lung adenocarcinoma patients with brain metastases after Gamma Knife radiosurgery: a propensity score-matched analysis based on extended JLGK0901 dataset (JLGK0901-EGFR-TKI).

Yomo S, Serizawa T, Yamamoto M, Higuchi Y, Sato Y, Shuto T, Akabane A, Jokura H, Kawagishi J, Aoyama H

Journal of neuro-oncology 145 ( 1 ) 151 - 157 2019.10

ISSN  0167-594X

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Effect of Empagliflozin on Endothelial Function in Patients With Type 2 Diabetes and Cardiovascular Disease: Results from the Multicenter, Randomized, Placebo-Controlled, Double-Blind EMBLEM Trial

Tanaka Atsushi, Shimabukuro Michio, Machii Noritaka, Teragawa Hiroki, Okada Yosuke, Shima Kosuke R., Takamura Toshinari, Taguchi Isao, Hisauchi Itaru, Toyoda Shigeru, Matsuzawa Yasushi, Tomiyama Hirofumi, Yamaoka-Tojo Minako, Yoshida Hisako, Sato Yasunori, Ikehara Yumi, Ueda Shinichiro, Higashi Yukihito, Node Koichi

DIABETES CARE 42 ( 10 ) E159 - E161 2019.10

ISSN  0149-5992

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Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey.

Suichi T, Misawa S, Beppu M, Takahashi S, Sekiguchi Y, Shibuya K, Amino H, Tsuneyama A, Suzuki YI, Nakamura K, Sato Y, Kuwabara S

Neurology 93 ( 10 ) e975 - e983 2019.09

ISSN  0028-3878

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Stereotactic radiosurgery in elderly patients with brain metastases: comparison with non-elderly patients using database of a multi-institutional prospective observational study (JLGK0901-Elderly)

Higuchi Y., Yamamoto M., Serizawa T., Sato Y., Shuto T., Akabane A., Jokura H., Yomo S., Nagano O., Kawagishi J., Yamanaka K., Aoyama H.

Journal of Neuro-Oncology (Journal of Neuro-Oncology)  144 ( 2 ) 393 - 402 2019.09

ISSN  0167594X

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© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: Stereotactic radiosurgery (SRS) has been increasingly used for elderly patients with brain metastases (BMs). However, no studies based on a large sample size have been reported. To compare SRS treatment results between elderly and non-elderly patients, we performed a subset study of elderly patients using our prospectively-accumulated multi-institution study database (JLGK0901 Study, Lancet Oncol 15:387–395, 2014). Methods: During the 2009–2011 period, 1194 eligible patients undergoing gamma knife SRS alone for newly diagnosed BMs were enrolled in this study from 23 gamma knife facilities in Japan. Observation was discontinued at the end of 2013. The 1194 patients were divided into the two age groups, 693 elderly (≥ 65 years) and 501 non-elderly (< 65 years) patients. Our study protocol neither set an upper age limit nor required dose de-escalation. Results: Median post-SRS survival time was significantly shorter in the elderly than in the non-elderly patient group (10.3 vs 14.3 months, HR 1.380, 95% CI 1.218–1.563, p < 0.0001). However, regarding all secondary endpoints including neurological death, neurological deterioration, SRS-related complications, leukoencephalopathy, local recurrence, newly-developed tumors, meningeal dissemination, salvage SRS, whole brain radiotherapy and surgery and decreased mini-mental state examination scores, the elderly patient group was not inferior to the non-elderly patient group. In the 693 elderly patients, there was no post-SRS median survival time difference between those with 5–10 versus 2–4 tumors (10.8 vs 8.9 months, HR 0.936, 95% CI 0.744–1.167, p = 0.5601). Conclusions: We conclude that elderly BM patients are not unfavorable candidates for SRS alone treatment.

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Short-term effect of empagliflozin on endothelial function in patients with type 2 diabetes and cardiovascular diseases: a placebo-controlled randomised trial (EMBLEM)

Tanaka A., Shimabukuro M., Machii N., Teragawa H., Okada Y., Shima K. R., Takamura T., Taguchi I., Hisauchi I., Sato Y., Ueda S., Higashi Y., Node K.

DIABETOLOGIA 62   S560 - S561 2019.09

ISSN  0012-186X

Genetic combination risk for schizophrenia.

Oishi K, Niitsu T, Kanahara N, Hashimoto T, Komatsu H, Sasaki T, Takase M, Sato Y, Iyo M

Schizophrenia research  2019.08

ISSN  0920-9964

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Impaired glucose tolerance and future cardiovascular risk after coronary revascularization: a 10-year follow-up report.

Tsuchida K, Mitsuma W, Sato Y, Ozaki K, Soda S, Hatada K, Tanaka K, Hosaka Y, Imai S, Takahashi K, Matsubara T, Oda H

Acta diabetologica  2019.08

ISSN  0940-5429

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Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open-label, blinded-endpoint, randomized controlled study (PRIME-V study)

Koshizaka M., Ishikawa K., Ishibashi R., Maezawa Y., Sakamoto K., Uchida D., Nakamura S., Yamaga M., Yokoh H., Kobayashi A., Onishi S., Kobayashi K., Ogino J., Hashimoto N., Tokuyama H., Shimada F., Ohara E., Ishikawa T., Shoji M., Ide S., Ide K., Baba Y., Hattori A., Kitamoto T., Horikoshi T., Shimofusa R., Takahashi S., Nagashima K., Sato Y., Takemoto M., Newby L., Yokote K.

Diabetes, Obesity and Metabolism (Diabetes, Obesity and Metabolism)  21 ( 8 ) 1990 - 1995 2019.08

ISSN  14628902

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© 2019 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. A prospective, multicentre, open-label, blinded-endpoint, randomized controlled study was conducted to evaluate the efficacy of treatment with ipragliflozin (sodium-dependent glucose transporter-2 inhibitor) versus metformin for visceral fat reduction and glycaemic control among Japanese patients with type 2 diabetes treated with sitagliptin, HbA1c levels of 7%-10%, and body mass index (BMI) ≥ 22 kg/m2. Patients were randomly assigned (1:1) to receive ipragliflozin 50 mg or metformin 1000-1500 mg daily. The primary outcome was change in visceral fat area as measured by computed tomography after 24 weeks of therapy. The secondary outcomes were effects on glucose metabolism and lipid metabolism. Mean percentage reduction in visceral fat area was significantly greater in the ipragliflozin group than in the metformin group (−12.06% vs. −3.65%, P = 0.040). Ipragliflozin also significantly reduced BMI, subcutaneous fat area, waist circumference, fasting insulin, and homeostatic model assessment (HOMA)-resistance, and increased HDL-cholesterol levels. Metformin significantly reduced HbA1c and LDL-cholesterol levels and increased HOMA-beta. There were no severe adverse events. The use of ipragliflozin or metformin in combination with dipeptidyl peptidase-4 inhibitors, widely used in Japan, may have beneficial effects in ameliorating multiple cardiovascular risk factors.

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Author Correction: Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers.

Hoshina A, Kawamoto T, Sueta SI, Mae SI, Araoka T, Tanaka H, Sato Y, Yamagishi Y, Osafune K

Scientific reports 9 ( 1 ) 10701 2019.07

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Applicability and limitations of a recently-proposed prognostic grading metric, initial brain metastasis velocity, for brain metastasis patients undergoing stereotactic radiosurgery

Yamamoto M., Aiyama H., Koiso T., Watanabe S., Kawabe T., Sato Y., Higuchi Y., Kasuya H., Barfod B.

Journal of Neuro-Oncology (Journal of Neuro-Oncology)  143 ( 3 ) 613 - 621 2019.07

ISSN  0167594X

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© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Purpose: This study, based on our brain metastasis (BM) patients undergoing stereotactic radiosurgery (SRS) procedures, aimed to validate whether the recently-proposed prognostic grading system, initial brain metastasis velocity (iBMV, scoring the cumulative number of BMs at the time of SRS divided by time [years] since the initial primary cancer diagnosis), is generally applicable. Methods: This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 3498 patients who underwent SRS for BMs during the 19.5-year-period between July, 1998 and December, 2017. We excluded four lost to follow-up, 24 for whom the day of primary cancer diagnosis was not available, 665 with synchronous presentation and 651 with pre-SRS radiotherapy and/or surgery, ultimately studying 2150 patients. Patients were categorized into two classes by iBMV scores, i.e., < 2.00 and ≥ 2.00. Results: In a multivariable model, iBMV was directly associated with a higher risk of death (p < 0.0001). The median survival time of patients with iBMV scores < 2.00, 10.0 (95% CI; 9.2–10.9) months, was longer than that of patients with iBMV scores ≥ 2.00, 6.3 (5.6–6.7) months, showing a significant difference between the two groups (HR 1.599, 95% CI 1.458–1.753, p < 0.0001). The same results were obtained in patients with non-small cell lung, breast, kidney or other cancers. Among 608 patients who underwent repeat SRS for newly-developed BMs, iBMV score categories correlated well with brain metastasis velocity risk groups (p < 0.0001). Conclusions: Our present results support the validity of iBMV for predicting survival after SRS.

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Nasopharyngeal Tube Effects on Breathing during Sedation for Dental Procedures: A Randomized Controlled Trial

Kohzuka Y., Isono S., Ohara S., Kawabata K., Kitamura A., Suzuki T., Almeida F., Sato Y., Iijima T.

Anesthesiology (Anesthesiology)  130 ( 6 ) 946 - 957 2019.06

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WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Dental procedures under sedation can cause hypoxic events and even death. However, the mechanism of such hypoxic events is not well understood. WHAT THIS ARTICLE TELLS US THAT IS NEW: Apnea and hypopnea occur frequently during dental procedures under sedation. The majority of the events are not detectable with pulse oximetry. Insertion of a nasal tube with small diameter does not reduce the incidence of apnea/hypopnea. BACKGROUND: Intravenous sedation is effective in patients undergoing dental procedures, but fatal hypoxemic events have been documented. It was hypothesized that abnormal breathing events occur frequently and are underdetected by pulse oximetry during sedation for dental procedures (primary hypothesis) and that insertion of a small-diameter nasopharyngeal tube reduces the frequency of the abnormal breathing events (secondary hypothesis). METHODS: In this nonblinded randomized control study, frequency of abnormal breathing episodes per hour (abnormal breathing index) of the patients under sedation for dental procedures was determined and used as a primary outcome to test the hypotheses. Abnormal breathing indexes were measured by a portable sleep monitor. Of the 46 participants, 43 were randomly allocated to the control group (n = 23, no nasopharyngeal tube) and the nasopharyngeal tube group (n = 20). RESULTS: In the control group, nondesaturated abnormal breathing index was higher than the desaturated abnormal breathing index (35.2 [20.6, 48.0] vs. 7.2 [4.1, 18.5] h, difference: 25.1 [95% CI, 13.8 to 36.4], P < 0.001). The obstructive abnormal breathing index was greater than central abnormal breathing index (P < 0.001), and half of abnormal breathing indexes were followed by irregular breathing. Despite the obstructive nature of abnormal breathing, the nasopharyngeal tube did not significantly reduce the abnormal breathing index (48.0 [33.8, 64.4] h vs. 50.5 [36.4, 63.9] h, difference: -2.0 [95% CI, -15.2 to 11.2], P = 0.846), not supporting the secondary hypothesis. CONCLUSIONS: Patients under sedation for dental procedure frequently encounter obstructive apnea/hypopnea events. The majority of the obstructive apnea/hypopnea events were not detectable by pulse oximetry. The effectiveness of a small-diameter nasopharyngeal tube to mitigate the events is limited.

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Comparison of olanexidine versus povidone-iodine for preventing surgical site infection in gastrointestinal surgery: Study protocol for a multicentre, single-blind, randomised controlled clinical trial

Takeuchi M., Obara H., Kawakubo H., Shinoda M., Okabayashi K., Mayanagi S., Irino T., Fukuda K., Nakamura R., Wada N., Kitago M., Yagi H., Abe Y., Oshima G., Hori S., Tsuruta M., Ishida T., Yokose T., Hirukawa K., Isobe Y., Sekimoto Y., Harada H., Maeda Y., Shito M., Kondo T., Sato Y., Kitagawa Y.

BMJ Open (BMJ Open)  9 ( 5 )  2019.05

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© 2019 Author(s). Introduction: The prevalence of surgical site infection (SSI) remains higher in gastrointestinal surgery than in other surgeries. Although several guidelines have indicated the efficacy of chlorhexidine and povidone-iodine in reducing the SSI rate, the optimal recommendation has still not been established. Therefore, it is necessary to determine the more effective antiseptic for surgical site preparation. Olanexidine (1.5% olanedine, Otsuka Pharmaceutical Factory, Tokushima, Japan), which is a new antiseptic in Japan, has antimicrobial activity against a wide range of bacteria, including Gram-positive and Gram-negative bacteria. Our study will contribute to determining a new antiseptic for use in gastrointestinal and other surgeries. Methods and analysis: We propose a multicentre, randomised controlled clinical trial for comparing two treatments, that is, 1.5% olanexidine or 10% povidone-iodine, for surgical skin preparation to prevent SSI in clean-contaminated gastrointestinal surgeries with surgical wounds. Patients aged ≥20 years at the time of consent will be included. The primary outcome measure is the 30-day postoperative SSI rate. For the primary analysis, which is aimed at comparing the treatment effects, the adjusted risk ratio and its 95% CI will be estimated using the Mantel-Haenszel method. Ethics and dissemination: The protocol was first approved by the Institutional Review Board of Keio University School of Medicine, followed by the institutional review board of each participating site. Participant recruitment began in June 2018. The final results will be published in international peer-reviewed medical journals.

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"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu E., Ogawa Y., Yazu H., Aketa N., Yang F., Yamane M., Sato Y., Kawakami Y., Tsubota K.

PLoS ONE (PLoS ONE)  14 ( 5 )  2019.05

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© 2019 Shimizu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Tear film breakup time (TFBUT) is an essential parameter used to diagnose dry eye disease (DED). However, a robust method for examining TFBUT in murine models has yet to be established. We invented an innovative device, namely, the "Smart Eye Camera", which addresses several problems associated with existing methods and is capable of evaluating TFBUT in a murine DED model. We compared images taken by existing devices and the Smart Eye Camera in a graft-versus-host disease-related DED murine model. We observed that the quality of the images obtained by the Smart Eye Camera were sufficient for practical use. Moreover, this new technique could be used to obtain measurements for several consecutive ocular phenotypes in a variety of environments. Here, we demonstrate the effectiveness of our new invention in the examination of ocular phenotypes, including TFBUT in a murine model. We highlight the potential for future translational studies adopting the Smart Eye Camera in clinical settings.

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Contact-free unconstraint respiratory measurements with load cells under the bed in awake healthy volunteers: Breath-by-breath comparison with pneumotachography

Isono S., Nozaki-Taguchi N., Hasegawa M., Kato S., Todoroki S., Masuda S., Iida N., Nishimura T., Noto M., Sato Y.

Journal of Applied Physiology (Journal of Applied Physiology)  126 ( 5 ) 1432 - 1441 2019.05

ISSN  87507587

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Copyright © 2019 the American Physiological Society. Rate of respiration is a fundamental vital sign. Accuracy and precision of respiratory rate measurements with contact-free load cell sensors under the bed legs were assessed by breath-by-breath comparison with the pneumotachography technique during two different dynamic breathing tasks in 16 awake human adults resting on the bed. The subject voluntarily increased and decreased the respiratory rate between 4 and 16 breaths/min (n 8) and 10 and 40 breaths/min (n 8) at every 2 breaths in 6 different lying postures such as supine, left lateral, right lateral, and 30, 45, and 60° sitting postures. Reciprocal phase changes of the upper and lower load cell signals accorded with the respiratory phases indicating respiratory-related shifts of the centroid along the long axis of the bed. Bland-Altman analyses revealed 0.66 and 1.59 breaths/min standard deviation differences between the techniques (limits of agreement: 1.22 to 1.36 and 2.96 to 3.30) and 0.07 and 0.17 breaths/min fixed bias differences (accuracy) (confidence interval: 0.04 to 0.10 and 0.12 to 0.22) for the mean respiratory rates of 10.5 3.7 and 24.6 8.9 breaths/min, respectively, regardless of the body postures on the bed. Proportional underestimation by this technique was evident for respiratory rates 40 breaths/min. Sample breath increase up to 10 breaths improved the precision from 1.59 to 0.26 breaths/min. Abnormally faster and slower respirations were accurately detected. We conclude that contact-free unconstraint respiratory rate measurements with load cells under the bed legs are accurate and may serve as a new clinical and investigational tool. NEW & NOTEWORTHY Four load cells placed under the bed legs successfully captured a centroid shift during respiration in human subjects lying on a bed. Breath-by-breath comparison of the breaths covering a wide respiratory rate range by pneumotachography confirmed reliability of the contact-free unconstraint respiratory rate measurements by small standard deviations and biases regardless of body postures. Abnormally faster and slower respirations were accurately detected. This technique should be an asset as a new clinical and investigational tool.

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Impact of nutrition in the treatment of congenital diaphragmatic hernia

Terui K., Usui N., Tazuke Y., Nagata K., Ito M., Okuyama H., Hayakawa M., Taguchi T., Sato Y., Yoshida H.

Pediatrics International (Pediatrics International)  61 ( 5 ) 482 - 488 2019.05

ISSN  13288067

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© 2019 Japan Pediatric Society Background: The optimum enteral (EN) and parenteral nutrition (PN) regimens during acute management of congenital diaphragmatic hernia (CDH) remain unclear. We examined the effects of EN and PN on weight gain in CDH patients. Methods: A multicenter retrospective cohort study of neonates with CDH (born 2006–2010; n = 105) who survived to discharge was conducted. Patients were divided as receiving PN ≥ or <50 kcal/kg/day at 1 week of age, and EN ≥ or <60 kcal/kg/day at 2 weeks of age. Changes in bodyweight at 30, 60, and 90 days of age were compared. Results: The higher EN group (n = 39) had greater mean weight gain than the lower EN group (n = 66; 90 days: 2,501 g, 95% CI: 2,294–2,710 g vs 1,706 g, 95% CI: 1,553–1,861 g; P <0.001). When patients received lower EN, the higher PN group (n = 24) had greater mean weight gain than the lower PN group (n = 42; 90 days: 1,768 g, 95% CI: 1,574–1,961 g vs 1,411 g, 95% CI: 1,264–1,558 g; P = 0.004). Conclusion: The amount of EN in the acute phase of CDH management is essential for weight gain during infancy. When patients are intolerant to adequate EN, supportive PN is also essential.

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Local tumor progression treated with Gamma Knife radiosurgery: differences between patients with 2-4 versus 5-10 brain metastases based on an update of a multi-institutional prospective observational study (JLGK0901).

Serizawa T, Yamamoto M, Higuchi Y, Sato Y, Shuto T, Akabane A, Jokura H, Yomo S, Nagano O, Kawagishi J, Yamanaka K

Journal of neurosurgery    1 - 10 2019.04

ISSN  0022-3085

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Pregnancy and neonatal outcomes of small follicle–derived blastocyst transfer in modified natural cycle in vitro fertilization

Teramoto S., Osada H., Sato Y., Shozu M.

Fertility and Sterility (Fertility and Sterility)  111 ( 4 ) 747 - 752 2019.04

ISSN  00150282

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© 2018 The Authors Objective: To compare the efficacy and safety of blastocyst transfer derived from small follicles (SF; ≤10 mm) and large follicles (LF; ≥11 mm). Design: Retrospective cohort study. Setting: Private clinic. Patient(s): Patients (n = 1,072) 30–40 years old who underwent blastocyst transfer (BT; n = 1,247) between January 2012 and December 2014. Intervention(s): Oocytes retrieved during a modified natural cycle from both LF and SF were fertilized by a conventional method or intracytoplasmic sperm injection. The blastocysts were frozen, thawed, and transferred one by one in the following spontaneous ovulatory cycles or hormone replacement cycles. Main Outcome Measure(s): BT resulted in live births and major congenital anomalies. Result(s): SF-derived BTs (n = 597) yielded 55 chemical abortions (9.2%), 73 clinical abortions (12.2%), and 261 live births (43.8%), whereas LF-derived BTs (n = 650) yielded 71 chemical abortions (10.9%), 73 clinical abortions (11.2%), and 311 live births (47.9%). These incidences were not statistically different between SF- and LF-derived BTs. The incidence of abnormal karyotypes was also not statistically different between SF- and LF-derived spontaneous abortions (71% [39/55] vs. 72% [40/55], respectively). The incidence of major congenital anomalies in neonates did not differ between SF- and LF-derived pregnancies (1.5% and 1.3%, respectively; relative risk = 1.10, 95% confidence interval [0.55–3.21]). Conclusion(s): SF-derived BT is as efficacious and safe as LF-derived BT.

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Validity of a Recently-Proposed Prognostic Grading Index, Brain Metastasis Velocity, for Brain Metastasis Patients Undergoing Multiple Radiosurgical Procedures

Yamamoto M, Aiyama H, Koiso T, Watanabe S, Kawabe T, Sato Y, Higuchi Y, Kasuya H, Barfod BE

Int J Radiat Oncol Biol Phys 103 ( 3 ) 631 - 637 2019.03

Research paper (scientific journal), Joint Work, Accepted

Postsurgical Salvage Radiosurgery for Nonfunctioning Pituitary Adenomas Touching/Compressing the Optic Chiasm: Median 13-Year Postirradiation Imaging Follow-up Results

Yamamoto M, Aiyama H, Koiso T, Watanabe S, Kawabe T, Sato Y, Higuchi Y, Barfod BE, Kasuya H

Neurosurgery 49 ( 2 ) 80 - 86 2019.02

Research paper (scientific journal), Joint Work, Accepted

Proposal of new clinical diagnostic criteria for POEMS syndrome

Suichi T, Misawa S, Sato Y, Beppu M, Sakaida E, Sekiguchi Y, Shibuya K, Watanabe K, Amino H, Kuwabara S

J Neurol Neurosurg Psychiatry (Journal of Neurology, Neurosurgery and Psychiatry)  90 ( 2 ) 133 - 137 2019.02

Research paper (scientific journal), Joint Work, Accepted,  ISSN  00223050

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© Author(s) (or their employer(s)) 2019. Objective To propose the optimal diagnostic criteria for polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome using appropriate statistical methods and disease controls. Methods This retrospective cohort study included 104 consecutive patients with suspected POEMS syndrome, among whom a gold standard group of 60 patients with definitive POEMS syndrome diagnosis were followed for at least 12 months to strictly exclude other disorders mimicking POEMS syndrome and to confirm response to POEMS syndrome-specific treatment. Thirty patients with chronic inflammatory demyelinating polyradiculoneuropathy (demyelinating polyradiculoneuropathy controls) and 30 with multiple myeloma or immunoglobulin light chain amyloidosis (monoclonal plasma cell proliferation controls) were also included. Logistic regression analyses were performed to determine optimal combination of clinical and laboratory abnormalities, characteristic of POEMS syndrome. Results The diagnostic criteria were statistically defined as the presence of the three major criteria (polyneuropathy (typically demyelinating), monoclonal plasma cell proliferative disorder and elevated vascular endothelial growth factor) and at least two of the four minor criteria (oedema/effusion, skin changes, organomegaly and sclerotic bone lesions), based on best performance by area under the receiver operating characteristic curve analyses. The sensitivity and specificity were 100% and 100%, respectively; the diagnostic accuracy of the proposed criteria was equivalent to somewhat complicated previous criteria. Conclusions The statistically defined, simple diagnostic criteria for POEMS syndrome could accelerate early diagnosis and treatment, thereby contribute to better outcome in patients with this serious disease. Prospective larger studies are required to confirm the validity.

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Displacement of the hyoid bone by muscle paralysis and lung volume increase: effects of obesity and obstructive sleep apnea

Kohno A, Kitamura Y, Kato S, Imai H, Masuda Y, Sato Y, Isono S

Sleep 42 ( 1 )  2019.01

Research paper (scientific journal), Joint Work, Accepted

大きな脳転移に対するガンマナイフによる三期的および二期的照射の治療成績の比較　後ろ向き多施設共同研究(JLGK1601)最終報告

芹澤 徹, 樋口 佳則, 山本 昌昭, 松永 成生, 永野 修, 佐藤 泰憲, 青柳 京子, 四方 聖二, 小磯 隆雄, 長谷川 俊典, 中崎 清之, 森木 章人, 近藤 威, 長友 康, 岡本 久代, 光田 幸彦, 河合 秀哉, 志藤 里香, 柴崎 徹, 尾上 信二, 祁内 博行, 井上 明, 森 久恵

定位的放射線治療 (日本定位放射線治療学会)  23   25 - 35 2019.01

ISSN  1342-9930

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腫瘍体積が10ml以上の大きな脳転移に対するガンマナイフによる三期的および二期的照射の治療成績を比較検討した。本試験参加19施設において総計1441例のガンマナイフによる段階的照射が施行され、このうち335例(三期114例、二期的照射221例)が登録された。生存期間中央値は三期群15.1ヵ月、二期群12.0ヵ月と三期群の方が長い傾向にあったが有意差を認めなかった。その他のすべての副次評価項目において両群間に有意差を認めなかった。Propensity score matchを用いて最終的に212例(両群106例)を選択し評価したところ、生存期間中央値は三期群15.9ヵ月、二期群11.7ヵ月と三期群の方が長い傾向にあったが有意差を認めなかった。1年における累積腫瘍増大発生頻度は三期群21.6%、二期群16.7%で有意差を認めなかった。その他、腫瘍再発、放射線壊死、神経死、有害事象においても両群間に有意差を認めなかった。

Addition of canagliflozin to insulin improves glycaemic control and reduces insulin dose in patients with type 2 diabetes mellitus: A randomized controlled trial

Torimoto K., Okada Y., Goshima Y., Tokutsu A., Sato Y., Tanaka Y.

Diabetes, Obesity and Metabolism (Diabetes, Obesity and Metabolism)  21 ( 9 ) 2174 - 2179 2019

ISSN  14628902

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© 2019 John Wiley & Sons Ltd The aim of this study was to evaluate the efficacy of canagliflozin in reducing the required insulin dose and the risk of hypoglycaemia in type 2 diabetes (T2D). This study was conducted in patients with T2D treated with insulin. They were randomly assigned to the control (n = 17) and canagliflozin (n = 17, plus 100 mg/day canagliflozin) groups. In both groups, a defined insulin dose adjustment protocol was applied to achieve the same level of glycaemic control. The change from baseline in daily insulin dose was significantly smaller in the canagliflozin group (3.9 units/day) than in the control group (13.4 units/day; P = 0.040). Low blood glucose index and predicted % of blood glucose (BG) <70 mg/dL, which are hypoglycaemia-related variables, worsened significantly in the control group but both remained unchanged in the canagliflozin group. The standard deviation for night-time BG levels improved significantly only in the canagliflozin group. Supplementation of insulin therapy with 100 mg canagliflozin in patients with T2D reduced the required insulin dose and hypoglycaemic risk and flattened night-time glycaemic fluctuations while maintaining the same level of glycaemic control.

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Risk score system for late aortic events in patients with uncomplicated type B aortic dissection

Matsushita A., Tabata M., Mihara W., Shimamoto T., Komiya T., Takanashi S., Tobaru T., Nakao T., Nakamura S., Sato Y.

Journal of Thoracic and Cardiovascular Surgery (Journal of Thoracic and Cardiovascular Surgery)   2019

ISSN  00225223

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© 2019 The American Association for Thoracic Surgery Objective: Several risk factors for late aortic events in patients with uncomplicated type B aortic dissection (UTBAD) have been reported; however, they remain controversial. We developed and validated a new risk prediction score system for late aortic events in patients with UTBAD. Methods: We reviewed 187 consecutive patients diagnosed with UTBAD from 2004 to 2017 at 2 centers (derivation cohort) and 219 consecutive patients diagnosed with UTBAD from 2012 to 2016 in 4 other centers (validation cohort). We explored predictors of late aortic events using Fine-Gray generalization of the proportional hazards model, then developed a risk prediction score model and determined the test reliability using time-dependent receiver operating characteristic analyses. Finally, we validated the model using external multicenter data. Results: The risk prediction score system was developed using the following independent predictors: initial aortic diameter of ≥40 mm (2 points), false lumen diameter larger than true lumen diameter (2 points), ulcer-like projection (1 point), and age ≥70 years (1 point). Receiver operating characteristic analysis showed that a cut-off total additive score of 2 points. In the validation cohort, the low-risk group (score, 0-1 point) demonstrated lower 1- and 3-year incidence rates of late aortic events than the high-risk group (score, 2-6 points) (0.9% vs 32.5% and 0.9% vs 47.1%, respectively; P < .0001). Conclusions: We developed a simple risk prediction score system for late aortic events in patients with UTBAD. High-risk patients can be identified using our model, and they should be closely monitored and considered for interventions at the appropriate timing.

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Stereotactic radiosurgery for patients with 10 or more brain metastases

Yamamoto M., Higuchi Y., Sato Y., Aiyama H., Kasuya H., Barfod B.

Progress in Neurological Surgery (Progress in Neurological Surgery)  34   110 - 124 2019

ISSN  00796492

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© 2019 S. Karger AG, Basel The JLGK0901 study showed the non-inferiority of stereotactic radiosurgery (SRS) alone as the initial treatment for 5-10 as compared to 2-4 brain metastases (BM) in terms of overall survival and most secondary endpoints [Lancet Oncol 2014;15:387-395]. A trend for patients with 5-10 tumors to undergo SRS alone has since become apparent. The next step is to reappraise whether results of SRS treatment alone for tumor numbers ≥10 differ from those for 2-9 tumors. During the past 2 decades, several retrospective studies have demonstrated the SRS alone treatment strategy to have certain benefits for carefully selected patients with ≥10 BM, i.e., a sufficiently long survival period with lower incidences of neurological death, neurological deterioration, local recurrence, and SRS-related complications. Herein, we introduce our Mito experiences with SRS for ≥10 BM, employing a case-matched study on 934 patients, 467 each in groups with 2-9 BM and ≥10 BM. Post-SRS treatment results, i.e., median survival time, neurological death-free survival time and cumulative incidences of local recurrence, repeat SRS for new lesions, neurological deterioration, and SRS-related complications, were not inferior for patients with ≥10 BM as compared to those with 2-9 BM. We conclude that patients with ≥10 tumors are not unfavorable candidates for SRS alone.

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Validation of the accuracy of self-reported abo blood types in the Japan nurses' health study

Alkebsi L., Ohnishi H., Nakajima-Shimada J., Onizuka Y., Ideno Y., Sato Y., Hayashi K.

Asian Pacific Journal of Cancer Prevention (Asian Pacific Journal of Cancer Prevention)  20 ( 3 ) 789 - 793 2019

ISSN  15137368

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© 2019 Asian Pacific Journal of Cancer Prevention. Background: The associations between ABO blood type and risk of diseases including cancer have been reported from epidemiological studies. Self-reporting is one of the most widely used methods of collecting the ABO blood type information. Verifying the accuracy of self-reporting is important to consider measurement errors. We aimed to conduct validation of self-reported ABO blood types in the Japan Nurses' Health Study (JNHS), which is a large prospective cohort study. Methods: The concordance rate between self-reported and serologically or genetically inferred ABO blood groups was investigated for a subsample of 41 subjects from the Gunma Nurses' Health Study, which was a pilot cohort study that preceded the JNHS. The presence of antibodies to A or B antigens in serum (serological test) and allele types of the ABO gene (genotyping test) were determined by using frozen blood samples that were preserved for approximately 7 years. ABO blood types were determined from these tests and compared with self-reported data. Results: All of the nurses reported that their ABO blood groups were concordant with those determined by a serological and/or genotyping test. Self-reported ABO blood types of 35 of 38 (92.1%) participants were consistent with the results from serological typing, while the answers of three participants were not. In these three participants, ABO genotypes that were inferred from genotyping of three single nucleotide polymorphisms in ABO loci perfectly matched with their self-reported ABO types, and all of these were O-type. Conclusions: Japanese health professionals report their blood type with a high degree of accuracy. Special attention should be paid to the O-type group in serological analysis of blood samples that have been preserved for several years in longitudinal studies.

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The Effect of Grandmothers' Presence on the Provision of Multidisciplinary Perinatal Support for Pregnant and Postpartum Women with Psychosocial Problems.

Ogawa M, Hashimoto T, Tanaka M, Tachibana M, Seki R, Sato A, Okayama J, Endo M, Saito N, Sato Y, Watanabe H, Nakazato M, Mori E, Shozu M, Iyo M

Journal of multidisciplinary healthcare 12   1033 - 1041 2019

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A pilot and feasibility study of a cognitive behavioural therapy-based anxiety prevention programme for junior high school students in Japan: a quasi-experimental study.

Ohira I, Urao Y, Sato Y, Ohtani T, Shimizu E

Child and adolescent psychiatry and mental health 13 ( 1 ) 40 2019

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Prognostic grading system specifically for elderly patients with brain metastases after stereotactic radiosurgery: A 2-institution study

Yamamoto M., Serizawa T., Higuchi Y., Nagano O., Aiyama H., Koiso T., Watanabe S., Kawabe T., Sato Y., Kasuya H.

Journal of Neurosurgery (Journal of Neurosurgery)  129   95 - 102 2018.12

ISSN  00223085

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©AANS 2018. OBJECTIVE With the aging of the population, increasing numbers of elderly patients with brain metastasis (BM) are undergoing stereotactic radiosurgery (SRS). Among recently reported prognostic grading indexes, only the basic score for brain metastases (BSBM) is applicable to patients 65 years or older. However, the major weakness of this system is that no BM-related factors are graded. This prompted the authors to develop a new grading system, the elderly-specific (ES)–BSBM. METHODS For this IRB-approved, retrospective cohort study, the authors used their prospectively accumulated database comprising 3267 consecutive patients undergoing Gamma Knife SRS for BMs during the 1998–2016 period at the Mito GammaHouse. Among these 3267 patients, 1789 patients ≥ 65 years of age were studied (Yamamoto series [Y-series]). Another series of 1785 patients ≥ 65 years of age in whom Serizawa and colleagues performed Gamma Knife SRS during the same period (Serizawa series [S-series]) was used for validity testing of the ES-BSBM. RESULTS Two factors were identified as strongly impacting longer survival after SRS by means of multivariable analysis using the Cox proportional hazard model with a stepwise selection procedure. These factors are the number of tumors (solitary vs multiple: HR 1.450, 95% CI 1.299–1.621; p < 0.0001) and cumulative tumor volume (≤ 15 cm3 vs > 15 cm3: HR 1.311, 95% CI 1.078–1.593; p = 0.0067). The new index is the addition of scores 0 and 1 for these 2 factors to the BSBM. The ES-BSBM system is based on categorization into 3 classes by adding these 2 scores to those of the original BSBM. Each ES-BSBM category has 2 possible scores. For the category ES-BSBM 4–5, the score is either 4 or 5; for ES-BSBM 2–3, the score is either 2 or 3; and for ES-BSBM 0–1, the score is either 0 or 1. In the Y-series, the median survival times (MSTs, months) after SRS were 17.5 (95% CI 15.4–19.3) in ES-BSBM 4–5, 6.9 (95% CI 6.4–7.4) in ES-BSBM 2–3, and 2.8 (95% CI 2.5–3.6) in ES-BSBM 0–1 (p < 0.0001). Also, in the S-series, MSTs were, respectively, 20.4 (95% CI 17.2–23.4), 7.9 (95% CI 7.4–8.5), and 3.2 (95% CI 2.8–3.6) (p < 0.0001). The ES-BSBM system was shown to be applicable to patients with all primary tumor types as well as to those 80 years or older. CONCLUSIONS The authors found that the addition of the number of tumors and cumulative tumor volume as scoring factors to the BSBM system significantly improved the prognostic value of this index. The present study is strengthened by testing the ES-BSBM in a different patient group.

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Three-stage Gamma Knife treatment for metastatic brain tumors larger than 10 cm³: A 2-institute study including re-analyses of earlier results using competing risk analysis

Yamamoto M., Higuchi Y., Serizawa T., Kawabe T., Nagano O., Sato Y., Koiso T., Watanabe S., Aiyama H., Kasuya H.

Journal of Neurosurgery (Journal of Neurosurgery)  129   77 - 85 2018.12

ISSN  00223085

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©AANS 2018. OBJECTIVE The results of 3-stage Gamma Knife treatment (3-st-GK-Tx) for relatively large brain metastases have previously been reported for a series of patients in Chiba, Japan (referred to in this study as the C-series). In the current study, the authors reappraised, using a competing risk analysis, the efficacy and safety of 3-st-GK-Tx by comparing their experience with that of the C-series. METHODS This was a retrospective cohort study. Among 1767 patients undergoing GK radiosurgery for brain metastases at Mito Gamma House during the 2005–2015 period, 78 (34 female, 44 male; mean age 65 years, range 35–86 years) whose largest tumor was > 10 cm3, treated with 3-st-GK-Tx, were studied (referred to in this study as the M-series). The target volumes were covered with a 50% isodose gradient and irradiated with a peripheral dose of 10 Gy at each procedure. The interval between procedures was 2 weeks. Because competing risk analysis had not been employed in the published C-series, the authors reanalyzed the previously published data using this method. RESULTS The overall median survival time after 3-st-GK-Tx was 8.3 months (95% CI 5.6–12.0 months) in the M-series and 8.6 months (95% CI 5.5–10.6 months) in the C-series (p = 0.41). Actuarial survival rates at the 6th and 12th post–3-st-GK-Tx months were, respectively, 55.1% and 35.2% in the M-series and 62.5% and 26.4% in the C-series (HR 1.175, 95% CI 0.790–1.728, p = 0.42). Cumulative incidences at the 12th post–3-st-GK-Tx, determined by competing risk analyses, of neurological deterioration (14.2% in C-series vs 12.8% in M-series), neurological death (7.2% vs 7.7%), local recurrence (4.8% vs 6.2%), repeat SRS (25.9% vs 18.0%), and SRS-related complications (2.3% vs 5.1%) did not differ significantly between the 2 series. CONCLUSIONS There were no significant differences in post–3-st-GK-Tx results between the 2 series in terms of overall survival times, neurological death, maintained neurological status, local control, repeat SRS, and SRS-related complications. The previously published results (C-series) are considered to be validated by the M-series results.

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Clinical significance of conformity index and gradient index in patients undergoing stereotactic radiosurgery for a single metastatic tumor

Aiyama H., Yamamoto M., Kawabe T., Watanabe S., Koiso T., Sato Y., Higuchi Y., Ishikawa E., Yamamoto T., Matsumura A., Kasuya H.

Journal of Neurosurgery (Journal of Neurosurgery)  129   103 - 110 2018.12

ISSN  00223085

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©AANS 2018. OBJECTIVE Although the conformity index (CI) and the gradient index (GI), which were proposed by Paddick and colleagues, are both logically considered to correlate with good posttreatment results after stereotactic radiosurgery (SRS), this hypothesis has not been confirmed clinically. The authors’ aim was to reappraise whether high CI values correlate with reduced tumor progression rates, and whether low GI values correlate with reduced complication incidences. METHODS This was an institutional review board–approved, retrospective cohort study conducted using a prospectively accumulated database including 3271 patients who underwent Gamma Knife SRS for brain metastases (BMs) during the 1998–2016 period. Among the 3271 patients, 925 with a single BM at the time of SRS (335 women and 590 men, mean age 66 [range 24–93] years) were studied. The mean/median CIs were 0.62/0.66 (interquartile range [IQR] 0.53–0.74, range 0.08–0.88) and the mean/median GIs were 3.20/3.09 (IQR 2.83–3.39, range 2.27–11.4). RESULTS SRS-related complications occurred in 38 patients (4.1%), with a median post-SRS interval of 11.5 (IQR 6.0–25.8, maximum 118.0) months. Cumulative incidences of post-SRS complications determined by a competing risk analysis were 2.2%, 3.2%, 3.6%, 3.8%, and 3.9% at the 12th, 24th, 36th, 48th, and 60th post-SRS month, respectively. Multivariable analyses showed that only two clinical factors (i.e., peripheral doses and brain volume receiving ≥ 12 Gy) correlated with complication rates. However, neither CIs nor GIs impacted the incidences of complications. Among the 925 patients, post-SRS MRI was performed at least once in 716 of them, who were thus eligible for local progression evaluation. Among these 716 patients, local progression was confirmed in 96 (13.4%), with a median post-SRS interval of 10.8 (IQR 6.7–19.5, maximum 59.8) months. Cumulative incidences of local progression determined by a competing risk analysis were 7.7%, 12.6%, 14.2%, 14.8%, and 15.3% at the 12th, 24th, 36th, 48th, and 60th post-SRS month, respectively. Multivariable analyses showed neurological symptoms, extracerebral metastases, repeat SRS, and CIs to correlate with incidences of local progression, whereas GIs had no impact on local tumor progression. Particularly, cumulative incidences of local progression were significantly lower in patients with CIs < 0.65 than in those with CIs ≥ 0.65 (adjusted hazard ratio 1.870, 95% confidence interval 1.299–2.843; p = 0.0034). CONCLUSIONS To the authors’ knowledge, this is the first analysis to focus on the clinical significance of CI and GI based on a large series of patients with BM. Contrary to the majority opinion that dose planning with higher CI and lower GI results in good post-SRS outcomes (i.e., low local progression rates and minimal complications), this study clearly showed that the lower the CIs were, the lower the local progression rates were, and that the GI did not impact complication rates.

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Multiinstitutional prospective observational study of stereotactic radiosurgery for patients with multiple brain metastases from non–small cell lung cancer (JLGK0901 study–NSCLC)

Shuto T., Akabane A., Yamamoto M., Serizawa T., Higuchi Y., Sato Y., Kawagishi J., Yamanaka K., Jokura H., Yomo S., Nagano O., Aoyama H.

Journal of Neurosurgery (Journal of Neurosurgery)  129   86 - 94 2018.12

ISSN  00223085

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©AANS 2018. OBJECTIVE Previous Japanese Leksell Gamma Knife Society studies (JLGK0901) demonstrated the noninferiority of stereotactic radiosurgery (SRS) alone as the initial treatment for patients with 5–10 brain metastases (BMs) compared with those with 2–4 BMs in terms of overall survival and most secondary endpoints. The authors studied the aforementioned treatment outcomes in a subset of patients with BMs from non–small cell lung cancer (NSCLC). METHODS Patients with initially diagnosed BMs treated with SRS alone were enrolled in this prospective observational study. Major inclusion criteria were the existence of up to 10 tumors with a maximum diameter of less than 3 cm each, a cumulative tumor volume of less than 15 cm3, and no leptomeningeal dissemination in patients with a Karnofsky Performance Scale score of 70% or better. RESULTS Among 1194 eligible patients, 784 with NSCLC were categorized into 3 groups: group A (1 tumor, n = 299), group B (2–4 tumors, n = 342), and group C (5–10 tumors, n = 143). The median survival times were 13.9 months in group A, 12.3 months in group B, and 12.8 months in group C. The survival curves of groups B and C were very similar (hazard ratio [HR] 1.037; 95% CI 0.842–1.277; p < 0.0001, noninferiority test). The crude and cumulative incidence rates of neurological death, deterioration of neurological function, newly appearing lesions, and leptomeningeal dissemination did not differ significantly between groups B and C. SRS-induced complications occurred in 145 (12.1%) patients during the median post-SRS period of 9.3 months (IQR 4.1–17.4 months), including 46, 54, 29, 11, and 5 patients with a Common Terminology Criteria for Adverse Events v3.0 grade 1, 2, 3, 4, or 5 complication, respectively. The cumulative incidence rates of adverse effects in groups A, B, and C 60 months after SRS were 13.5%, 10.0%, and 12.6%, respectively (group B vs C: HR 1.344; 95% CI 0.768–2.352; p = 0.299). The 60-month post-SRS rates of neurocognitive function preservation were 85.7% or higher, and no significant differences among the 3 groups were found. CONCLUSIONS In this subset analysis of patients with NSCLC, the noninferiority of SRS alone for the treatment of 5–10 versus 2–4 BMs was confirmed again in terms of overall survival and secondary endpoints. In particular, the incidence of neither post-SRS complications nor neurocognitive function preservation differed significantly between groups B and C. These findings further strengthen the already-reported noninferiority hypothesis of SRS alone for the treatment of patients with 5–10 BMs.

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Vulnerable combinations of functional polymorphisms to the late-onset treatment resistant schizophrenia

Oishi K, Kanahara N, Takase M, Oda Y, Nakata Y, Niitsu T, Ishikawa M, Sato Y and Iyo M

PLOS ONE 13 ( 11 ) e0207133 2018.11

Research paper (scientific journal), Joint Work, Accepted

Differences of Recovery from Rocuronium-induced Deep Paralysis in Response to Small Doses of Sugammadex between Elderly and Nonelderly Patients

Muramatsu T, Isono S, Ishikawa T, Nozaki-Taguchi N, Okazaki J, Kitamura Y, Murakami N, Sato Y

Anesthesiology (Anesthesiology)  129 ( 5 ) 901 - 911 2018.11

Research paper (scientific journal), Joint Work, Accepted,  ISSN  00033022

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© 2018, the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved. Anesthesiology 2018; 129:901-11 Background: Complete recovery from rocuronium-induced muscle paralysis with sugammadex is reported to be delayed in elderly patients. The authors tested a hypothesis that recovery from deep neuromuscular block with low-dose sugammadex is slower (primary hypothesis) and incidence of recurarization is higher (secondary hypothesis) in elderly patients than in nonelderly patients. Methods: In anesthetized elderly (n = 20; 76.9 ± 5.0 yr of age) and nonelderly patients (n = 20; 53.7 ± 12.8 yr of age) under deep paralysis with rocuronium, change of train-of-four ratio per minute (primary outcome variable) was measured with an accelero-myograph neuromuscular monitor during spontaneous recovery from rocuronium-induced muscle paralysis (0.6 mg/kg) and after infusion of low-dose sugammadex (50 µg · kg-1 · min-1). Recurarization was defined as the negative change of train-of-four ratio. Results: Spontaneous train-of-four ratio recovery rate was significantly slower in the elderly group (median [25th percentile, 75th percentile]: 1.89 [1.22, 2.90] %/min) than in the nonelderly group (3.45 [1.96, 4.25] %/min, P = 0.024). Train-of-four ratio change rate in response to low-dose sugammadex was significantly slower in elderly (0.55 [-0.29, 1.54] %/min) than in the nonelderly group (1.68 [0.73, 3.13] %/min, P = 0.024). Incidence of recurarization was significantly higher in the elderly group than in the nonelderly group (35% vs. 5%, P = 0.044). Multiple linear regression analyses indicate that slower spontaneous train-of-four ratio recovery rate and impaired renal function are two major contributing factors that decrease train-of-four ratio change rate in response to low-dose sugammadex. Conclusions: Elderly patients are at greater risk for recurarization and residual muscle paralysis when low-dose sugammadex is administered.

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Vulnerable combinations of functional dopaminergic polymorphisms to late-onset treatment resistant schizophrenia

Oishi K., Kanahara N., Takase M., Oda Y., Nakata Y., Niitsu T., Ishikawa M., Sato Y., Iyo M.

PLoS ONE (PLoS ONE)  13 ( 11 )  2018.11

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© 2018 Oishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background A significant portion of patients with schizophrenia who respond to initial antipsychotic treatment acquire treatment resistance. One of the possible pathogeneses of treatment-resistant schizophrenia (TRS) is antipsychotic-induced dopamine supersensitivity psychosis (Ai-DSP). Patients with this disease progression might share some genetic vulnerabilities, and thus determining individuals with higher risks of developing Ai-DSP could contribute to preventing iatrogenic development of TRS. Therefore, we decided to examine whether combinations of functional single nucleotide polymorphisms (SNPs) known to affect dopaminergic functions are related to Ai-DSP development. Methods In this case-control study, 357 Japanese participants diagnosed with schizophrenia or schizoaffective disorder were recruited and divided into two groups, those with and without Ai-DSP. As functional SNPs, we examined rs10770141 of the tyrosine hydroxylase gene, rs4680 of the catechol-O-methyltransferase gene, and rs1799732 and rs1800497 of the DRD2 genes, which are known to possess strong directional ties to dopamine synthesis, dopamine degradation and post-synaptic DRD2 prevalence, respectively. Results Among the 357 Japanese patients with schizophrenia or schizoaffective disorder, 130 were classified as Ai-DSP(+) and the other 227 as Ai-DSP(-). Significantly higher proportions of Ai-DSP(+) patients were found to have the SNP combinations of rs10770141/rs4680 (57.9%, OR2.654, 95%CI1.036–6.787, P = 0.048) and rs10770141/rs4680/rs1800497 (64.3%, OR4.230, 95%CI1.306–13.619, P = 0.029). However, no single SNP was associated with Ai-DSP. Conclusions We preliminarily found that carrying particular combinations of functional SNPs, which are related to relatively higher dopamine synthesis and dopamine degradation and lower naïve DRD2, might indicate vulnerability to development of Ai-DSP. However, further studies are needed to validate the present results.

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Comparison of treatment results between 3- and 2-stage Gamma Knife radiosurgery for large brain metastases: a retrospective multi-institutional study

Serizawa, T., Higuchi, Y., Yamamoto, M., Matsunaga, S., Nagano, O., Sato, Y., Aoyagi, K., Yomo, S., Koiso, T., Hasegawa, T., Nakazaki, K., Moriki, A., Kondoh, T., Nagatomo, Y., Okamoto, H., Kohda, Y., Kawai, H., Shidoh, S., Shibazaki, T., Onoue, S., Kenai, H., Inoue, A. and Mori, H.

J Neurosurg    1 - 11 2018.09

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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OBJECTIVE In order to obtain better local tumor control for large (i.e., > 3 cm in diameter or > 10 cm(3) in volume) brain metastases (BMs), 3-stage and 2-stage Gamma Knife surgery (GKS) procedures, rather than a palliative dose of stereotactic radiosurgery, have been proposed. Here, authors conducted a retrospective multi-institutional study to compare treatment results between 3-stage and 2-stage GKS for large BMs. METHODS This retrospective multi-institutional study involved 335 patients from 19 Gamma Knife facilities in Japan. Major inclusion criteria were 1) newly diagnosed BMs, 2) largest tumor volume of 10.0-33.5 cm(3), 3) cumulative intracranial tumor volume </= 50 cm(3), 4) no leptomeningeal dissemination, 5) no more than 10 tumors, and 6) Karnofsky Performance Status 70% or better. Prescription doses were restricted to between 9.0 and 11.0 Gy in 3-stage GKS and between 11.8 and 14.2 Gy in 2-stage GKS. The total treatment interval had to be within 6 weeks, with at least 12 days between procedures. There were 114 cases in the 3-stage group and 221 in the 2-stage group. Because of the disproportion in patient numbers and the pre-GKS clinical factors between these two GKS groups, a case-matched study was performed using the propensity score matching method. Ultimately, 212 patients (106 from each group) were selected for the case-matched study. Overall survival, tumor progression, neurological death, and radiation-related adverse events were analyzed. RESULTS In the case-matched cohort, post-GKS median survival time tended to be longer in the 3-stage group (15.9 months) than in the 2-stage group (11.7 months), but the difference was not statistically significant (p = 0.65). The cumulative incidences of tumor progression (21.6% vs 16.7% at 1 year, p = 0.31), neurological death (5.1% vs 6.0% at 1 year, p = 0.58), or serious radiation-related adverse events (3.0% vs 4.0% at 1 year, p = 0.49) did not differ significantly. CONCLUSIONS This retrospective multi-institutional study showed no differences between 3-stage and 2-stage GKS in terms of overall survival, tumor progression, neurological death, and radiation-related adverse events. Both 3-stage and 2-stage GKS performed according to the aforementioned protocols are good treatment options in selected patients with large BMs.

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Modern management for brain metastasis patients using stereotactic radiosurgery: literature review and the authors' gamma knife treatment experiences

Higuchi, Y., Yamamoto, M., Serizawa, T., Aiyama, H., Sato, Y. and Barfod, B. E.

Cancer Manag Res (Cancer Management and Research)  10   1889 - 1899 2018.09

Research paper (scientific journal), Joint Work,  ISSN  1179-1322

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Historically, whole brain radiotherapy was administered to most patients with brain metastases. However, over the past three decades, stereotactic radiosurgery (SRS), targeted at individual cranial lesions, has been accepted widely. In this study, based on the authors' experiences along with published data, recent trends in SRS for brain metastases are discussed. This article focuses on the following issues: 1) How many tumors can or should be treated with SRS? 2) Two-/three-staged SRS for relatively large tumors, 3) post- or preoperative SRS, and 4) repeat SRS.

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Is ganglionated plexus ablation effective for treating atrial fibrillation?

Watanabe, Michiko, Kohno, Hiroki, Kondo, Yusuke, Ueda, Hideki, Ishida, Keiichi, Tamura, Yusaku, Abe, Shinichiro, Sato, Yasunori, Kobayashi, Yoshio, Matsumiya, Goro

SURGERY TODAY (Surgery Today)  48 ( 9 ) 875 - 882 2018.09

Research paper (scientific journal), Joint Work,  ISSN  0941-1291

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© 2018, Springer Nature Singapore Pte Ltd. Purpose: Very few studies have investigated the efficacy of ganglionated plexus ablation during the conventional maze procedure. In this study, we sought to evaluate its additive effect in reducing recurrent atrial fibrillation after concomitant maze surgery. Methods: A retrospective study was conducted of 79 patients who underwent Cox maze IV concomitantly with open-heart surgery with (GP group) or without (Maze group) ganglionated plexus mapping. All active ganglionated plexuses were ablated. The two groups were compared and their follow-up data were analyzed. Results: Active ganglionated plexuses were found in 81% of patients who underwent ganglionated plexus mapping. The rates of freedom from atrial fibrillation at 1 year in the GP and Maze groups were 77 and 75%, respectively. The cumulative freedom from atrial fibrillation at follow-up (27.7 ± 17.3 months) was comparable in the two groups (p = 0.427). A multivariate analysis revealed that persistent atrial fibrillation for more than 90 months was an independent predictor of recurrent atrial fibrillation. Conclusion: Ganglionated plexus ablation with Cox maze IV did not reduce the incidence of recurrent atrial fibrillation in comparison to Maze alone.

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Postsurgical Salvage Radiosurgery for Nonfunctioning Pituitary Adenomas Touching/Compressing the Optic Chiasm: Median 13-Year Postirradiation Imaging Follow-up Results

Yamamoto, M., Aiyama, H., Koiso, T., Watanabe, S., Kawabe, T., Sato, Y., Higuchi, Y., Barfod, B. E. and Kasuya, H.

Neurosurgery  2018.08

Research paper (scientific journal), Joint Work,  ISSN  0148-396

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BACKGROUND: There is little information on long-term outcomes after salvage treatment by either surgery or stereotactic radiosurgery (SRS) for patients with recurrent/residual nonfunctioning pituitary adenomas (NFPAs). OBJECTIVE: To reappraise the efficacy and safety of SRS for patients with NFPAs touching/compressing the optic apparatus (OA). METHODS: We studied 27 patients (14 females, 13 males; mean age: 61 [range, 19-85] yr) who underwent SRS between 1998 and 2008 for NFPAs with such condition. The median tumor volume was 4.9 (range, 1.8-50.8) cc. To avoid excess irradiation to the OA, the lower part of the tumor was covered with a 50% or a 60% isodose gradient, ie 49% to 98% (mean, 84%; median, 88%) of the entire tumor received the selected doses. Median doses at the tumor periphery/OA were 7.6/11.0 (interquartile range [IQR], 5.8-9.1/10.1-11.8) Gy. RESULTS: Seven patients (26%) were confirmed to be deceased due to unrelated diseases at a median post-SRS period of 149 (IQR, 83-158) mo. Follow-up magnetic resonance imaging (MRI) showed tumor growth in 2 patients (7%) at the 11th and 134th post-SRS month; the former underwent surgery and the other SRS. Excluding these 2 patients, the latest follow-up MRI examinations, performed 13 to 238 (median: 168, IQR: 120-180) mo after SRS, showed no size changes in 5 (19%) and shrinkage in 20 (74%) patients. Cumulative incidences of tumor growth control were 96.3% and 91.8% at the 120th and 180th post-SRS month. None of our patients developed subjective symptoms suggesting SRS-induced optic neuropathy or endocrinological impairment. CONCLUSION: In patients with NFPAs touching/compressing the OA, SRS achieves good long-term results.

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Comparison of meniscal extrusion and osteophyte formation at the intercondylar notch as a predictive biomarker for incidence of knee osteoarthritis-Data from the Osteoarthritis Initiative

Okada, K., Yamaguchi, S., Sato, Y., Enomoto, T., Ogawa, Y., Ohtori, S., Tahara, M. and Sasho, T.

J Orthop Sci (Journal of Orthopaedic Science)  24 ( 1 ) 121 - 127 2018.08

Research paper (scientific journal), Joint Work,  ISSN  0949-2658

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BACKGROUND: Medial meniscal extrusion (ME) is a biomarker to predict later development of knee osteoarthritis (KOA). On the other hand, we have reported osteophyte formation at the posterior condylar notch of the femur served as a biomarker for the same purpose. The purpose of this study is to compare capacity of the two biomarkers in predicting KOA development. METHODS: Two cohort of knees were established utilizing publicly available data from the Osteoarthritis Initiative (OAI). No OA group (NOA) consisted of knees that were grade 0 or 1 on Kellgren and Lawrence grade (K/L) both at baseline and 48 months later, and pre-radiographic-OA group (PROA) consisted of knees that were grade 0 or 1 at baseline but grade >/=2 48 months later. Baseline MR images were evaluated in terms of ME and osteophyte formation at the posterior condylar notch. ME was evaluated both by meniscus subluxation index (MSI) indicating the ratio of the extruded width of the medial meniscus to the width of medial meniscal body and by the medial radial displacement (MRD) indicating actual extruded width. The size of the osteophyte was assessed using a semi-quantitative whole-organ magnetic resonance imaging score (WORMS). The predictive accuracy of KOA was assessed by the area under the receiver operating characteristic curve (AUC) and optimal cutoff was determined for each parameter. RESULTS: The AUC for MSI was 0.654 (0.561-0.748: 95% CI) and the cutoff value was determined as 17%. That for MRD was 0.677 (0.584-0.770) and the cutoff value was 2.2 mm. The AUC for the WORMS score at the posterior condylar notch was 0.667 (0.579-0.756) and the cutoff value was 2. CONCLUSIONS: Similar predicting capacity of KOA development was found both in ME and osteophyte formation at the posterior condylar notch. Using these simple parameter, mas-screening for KOA development would be possible.

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Development of a self-efficacy questionnaire, "Insulin Therapy Self-efficacy Scale (ITSS)", for insulin users in Japanese: THE SELF-EFFICACY-Q study

Nakaue, J., Koizumi, M., Nakajima, H., Okada, S., Mohri, T., Akai, Y., Furuya, M., Hayashino, Y., Sato, Y. and Ishii, H.

J Diabetes Investig (Journal of Diabetes Investigation)  10 ( 2 ) 358 - 366 2018.08

Research paper (scientific journal), Joint Work,  ISSN  2040-1116

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AIMS/INTRODUCTION: Although patient self-efficacy is known to affect adherence to therapy, no available tool measures self-efficacy of insulin therapy administration while addressing the entire therapeutic process and management. In light of this, we developed the "Insulin Therapy Self-efficacy Scale (ITSS)". MATERIALS AND METHODS: Development of the ITSS involved three phases: 1) item generation and creation of a questionnaire draft; 2) testing and correcting the items through interviews with patients; and 3) a multicenter single arm study to validate the questionnaire. RESULTS: A factor analysis and Cronbach's alpha both confirmed good internal consistency in the subjects' confidence regarding the following four factors: the insulin injection procedure, insulin titration, glycemic control, and ability to cope with hypoglycemia. Reproducibility was confirmed using weighted kappa statistics and intra-class correlations. Good concurrent validity was confirmed with two other questionnaires. The ITSS score was also found to correlate with several patient characteristics and clinical parameters, as well as with a better adherence to injected insulin therapy 6 months later, suggesting the predictive validity of this scale. CONCLUSIONS: The ITSS is a reliable and valid tool for assessing and quantifying patients' self-efficacy. The ITSS estimation of self-efficacy can predict a patient's glycemic control and future adherence to insulin therapy. These characteristics will ensure the usefulness of the ITSS in ensuring a successful therapeutic process for patients and physicians. This article is protected by copyright. All rights reserved.

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The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

Kotooka N, Kitakaze M, Nagashima K, Asaka M, Kinugasa Y, Nochioka K, Mizuno A, Nagatomo D, Mine D, Yamada Y, Kuratomi A, Okada N, Fujimatsu D, Kuwahata S, Toyoda S, Hirotani SI, Komori T, Eguchi K, Kario K, Inomata T, Sugi K, Yamamoto K, Tsutsui H, Masuyama T, Shimokawa H, Momomura SI, Seino Y, Sato Y, Inoue T, Node K; HOMES-HF study investigators.

HEART AND VESSELS (Heart and Vessels)  33 ( 8 ) 866 - 876 2018.08

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0910-8327

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© 2018, Springer Japan KK, part of Springer Nature. Home telemonitoring is becoming more important to home medical care for patients with heart failure. Since there are no data on home telemonitoring for Japanese patients with heart failure, we investigated its effect on cardiovascular outcomes. The HOMES-HF study was the first multicenter, open-label, randomized, controlled trial (RCT) to elucidate the effectiveness of home telemonitoring of physiological data, such as body weight, blood pressure, and pulse rate, for Japanese patients with heart failure (UMIN Clinical Trials Registry 000006839). The primary end-point was a composite of all-cause death or rehospitalization due to worsening heart failure. We analyzed 181 recently hospitalized patients with heart failure who were randomly assigned to a telemonitoring group (n = 90) or a usual care group (n = 91). The mean follow-up period was 15 (range 0–31) months. There was no statistically significant difference in the primary end-point between groups [hazard ratio (HR), 0.95; 95% confidence interval (CI), 0.548–1.648; p = 0.572]. Home telemonitoring for Japanese patients with heart failure was feasible; however, beneficial effects in addition to those of usual care were not demonstrated. Further investigation of more patients with severe heart failure, participation of home medical care providers, and use of a more integrated home telemonitoring system emphasizing communication as well as monitoring of symptoms and physiological data are required.

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Identifying improvable employment-related factors in schizophrenia patients

Hasegawa, Tadashi, Hashimoto, Tasuku, Kanahara, Nobuhisa, Yamanaka, Hiroshi, Ishige, Minoru, Sato, Yasunori, Iyo, Masaomi

PSYCHIATRY RESEARCH (Psychiatry Research)  266   199 - 205 2018.08

Research paper (scientific journal), Joint Work,  ISSN  0165-1781

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© 2018 Elsevier B.V. Although many studies report various factors related to future employment of schizophrenia patients, few identify the treatable or improvable ones. The responses to the first year of treatment and daily antipsychotic drug doses may be the treatable and improvable factors. We surveyed 235 schizophrenia outpatients in three facilities, of whom 129 and 106 were employed and unemployed, respectively. Through face-to-face interviews and medical record reviews, we investigated symptomatic and social functioning responses to the first year of treatment using the Global Assessment of Psychopathology Scale (GAPS) and the Social and Occupational Functioning Assessment Scale (SOFAS). We investigated daily antipsychotic drug doses and other clinical assessments at the interview time. Finally, we used multivariable logistic regression analysis. SOFAS-measured improvements in the period 6 to 12 months after beginning treatment and daily antipsychotic drug doses equivalent to less than 600 mg of chlorpromazine were identified as an employment-related factor, but GAPS-measure improvements were not. Social functioning improvements in the period 6 to 12 months after beginning treatment and low-to-moderate daily antipsychotic drug doses were detected as employment-related factors, suggesting that early efforts to improve social functioning and optimize antipsychotic drug doses could lead to future employment for schizophrenia patients.

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Avulsion fracture of the distal fibula is associated with recurrent sprain after ankle sprain in children

Yamaguchi, S., Akagi, R., Kimura, S., Sadamasu, A., Nakagawa, R., Sato, Y., Kamegaya, M., Sasho, T. and Ohtori, S.

Knee Surg Sports Traumatol Arthrosc (Knee Surgery, Sports Traumatology, Arthroscopy)  27 ( 9 ) 2774 - 2780 2018.07

Research paper (scientific journal), Joint Work,  ISSN  0942-2056

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PURPOSE: The purpose of this study was to clarify radiographic and clinical outcomes, as well as their association, of ankle sprain in children. METHODS: Patients who sustained a first-time ankle sprain were prospectively surveyed. Patients underwent radiography of the ankle in the mortise, lateral, anterior talofibular ligament (ATFL), and calcaneofibular ligament views at the first clinic visit to assess avulsion fractures of the distal fibula. Patients with avulsion fractures underwent radiography after 8 weeks to assess bone union. The treatment method was not standardized and was determined by the patient, their parents, and the treating physician. Recurrent sprain and quality of life were evaluated by using the Self-Administered Foot Evaluation Questionnaire and reviewing the medical records of patients. The association between avulsion fracture and recurrent sprain was assessed using univariate and multivariate analyses. RESULTS: A total of 143 patients with a median age of 9 (range 6-12) years were analyzed. Avulsion fractures were present in 89 (62%) patients. The sensitivity of the ATFL view for the diagnosis of avulsion fractures was 0.94, whereas that for the anteroposterior and lateral views was significantly lower at 0.46 (P < 0.001). Only 17% of fractures united at 8 weeks. Of 114 (follow-up rate, 80%) patients who were followed up for a median period of 24 months, recurrent sprain occurred in 41 (36%) patients. The incidence rate was significantly higher in patients with avulsion fractures than in patients without the fractures (44 vs. 23%, P = 0.027). In multivariate logistic regression analysis, avulsion fracture was independently associated with recurrent sprain (P = 0.027). CONCLUSION: More than one-third of patients experienced recurrent sprain. The presence of avulsion fracture was associated with an increased risk of recurrent sprain. Patients with avulsion fracture and their parents should be informed about the risk of recurrent sprain and subsequent ankle instability, and careful follow-up is needed for these patients. LEVEL OF EVIDENCE: III.

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Medical costs attributable to overweight and obesity in Japanese individuals

Fujita, M., Sato, Y., Nagashima, K., Takahashi, S. and Hata, A.

Obes Res Clin Pract (Obesity Research and Clinical Practice)  12 ( 5 ) 479 - 484 2018.06

Research paper (scientific journal), Joint Work,  ISSN  1871-403X

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OBJECTIVE: We aimed to reveal the association between body mass index (BMI) and medical costs in the current Japanese population, and to estimate the population attributable fraction (PAF) of medical costs due to overweight and obesity. METHODS: A generalized linear mixed model with log link function and gamma distribution was used to evaluate the association between BMI and medical costs in 34,537 beneficiaries of the National Health Insurance aged 40-69 years in Chiba City. Medical cost data were obtained from insurance claims submitted between April 2012 and March 2016. PAFs due to overweight (BMI >/=25.0 and <30.0kg/m(2)) and obesity (BMI >/=30.0kg/m(2)) were calculated. RESULTS: Overweight and obesity were significant predictors of excessive medical costs in all age and sex groups. PAF due to overweight and obesity was estimated to be 9.62% (95% confidence interval, 8.52-10.73%). Additionally, PAFs in 40-59-year-old individuals (12.76% in men and 11.63% in women) were greater than those in 60-69-year-old subjects (6.55% in men and 7.80% in women) for both sexes. CONCLUSIONS: In the Japanese population, overweight and obesity are an excessive financial burden with an estimated PAF of 9.62% of total medical costs.

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The effects of xanthine oxidase inhibitor in patients with chronic heart failure complicated with hyperuricemia: a prospective randomized controlled clinical trial of topiroxostat vs allopurinol-study protocol

Sakuma, M., Toyoda, S., Arikawa, T., Koyabu, Y., Kato, T., Adachi, T., Suwa, H., Narita, J. I., Anraku, K., Ishimura, K., Yamauchi, F., Sato, Y. and Inoue, T.

Clin Exp Nephrol (Clinical and Experimental Nephrology)  22 ( 6 ) 1379 - 1386 2018.06

Research paper (scientific journal), Joint Work,  ISSN  1342-1751

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BACKGROUND: Hyperuricemia has a close relationship with cardiovascular diseases including heart failure. However, it is controversial whether xanthine oxidase inhibition has benefits for patients with chronic heart failure. We designed the Effect of Xanthine Oxidase Inhibitor in Chronic Heart Failure Patients Complicated with Hyperuricemia study (Excited-UA study) to compare the beneficial effects between a novel xanthine oxidoreductase inhibitor, topiroxostat, and a conventional agent, allopurinol, in patients with chronic heart failure and hyperuricemia. We focus on serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level, echocardiography-based cardiac function, vascular endothelial function, renal function, inflammation, and oxidative stress. METHODS: The excited-UA is a prospective, randomized, open-label, blinded-endpoint clinical trial designed to prove our hypothesis that topiroxostat is more effective than allopurinol in patients with chronic heart failure and hyperuricemia. A total of 140 patients with chronic heart failure and hyperuricemia (plasma brain natriuretic peptide level >/= 40 pg/mL and serum uric acid level >/= 7.0 mg/dL) are randomly assigned (ratio 1:1) into either the topiroxostat group (40-160 mg/day) or allopurinol group (100-300 mg/day), to achieve the target uric acid level of 6.0 mg/dL. According to the protocol, all patients are followed up annually for 24 weeks. The primary endpoint is percent change in serum NT-proBNP level at 24 weeks from baseline. CONCLUSIONS: The Excited-UA study would provide novel evidence for the clinical relevancy of xanthine oxidoreductase inhibitor treatment in patients with chronic heart failure and hyperuricemia.

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Safety and efficacy of eculizumab in Guillain-Barre syndrome: a multicentre, double-blind, randomised phase 2 trial

Misawa S, Kuwabara S, Sato Y, Yamaguchi N, Nagashima K, Katayama K, Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kanouchi T, Kohara N, Kawamoto M, Ishii J, Kuwahara M, Suzuki H, Hirata K, Kokubun N, Masuda R, Kaneko J, Yabe I, Sasaki H, Kaida KI, Takazaki H, Suzuki N, Suzuki S, Nodera H, Matsui N, Tsuji S, Koike H, Yamasaki R, Kusunoki S; Japanese Eculizumab Trial for GBS (JET-GBS) Study Group.

LANCET NEUROLOGY (The Lancet Neurology)  17 ( 6 ) 519 - 529 2018.06

Research paper (scientific journal), Joint Work,  ISSN  1474-4422

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© 2018 Elsevier Ltd Background: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of eculizumab, a humanised monoclonal antibody against the complement protein C5, in patients with severe Guillain-Barré syndrome. Methods: This study was a 24 week, multicentre, double-blind, placebo-controlled, randomised phase 2 trial done at 13 hospitals in Japan. Eligible patients with Guillain-Barré syndrome were aged 18 years or older and could not walk independently (Guillain-Barré syndrome functional grade 3–5). Patients were randomly assigned (2:1) to receive 4 weeks of intravenous immunoglobulin plus either eculizumab (900 mg) or placebo; randomisation was done via a computer-generated process and web response system with minimisation for functional grade and age. The study had a parallel non-comparative single-arm outcome measure. The primary outcomes were efficacy (the proportion of patients with restored ability to walk independently [functional grade ≤2] at week 4) in the eculizumab group and safety in the full analysis set. For the efficacy endpoint, we predefined a response rate threshold of the lower 90% CI boundary exceeding 50%. This trial is registered with ClinicalTrials.gov, number, NCT02493725. Findings: Between Aug 10, 2015, and April 21, 2016, 34 patients were assigned to receive either eculizumab (n=23) or placebo (n=11). At week 4, the proportion of the patients able to walk independently (functional grade ≤2) was 61% (90% CI 42–78; n=14) in the eculizumab group, and 45% (20–73; n=5) in the placebo group. Adverse events occurred in all 34 patients. Three patients had serious adverse events: two in the eculizumab group (anaphylaxis in one patient and intracranial haemorrhage and abscess in another patient) and one in the placebo group (depression). The possibility that anaphylaxis and intracranial abscess were related to eculizumab could not be excluded. No deaths or meningococcal infections occurred. Interpretation: The primary outcome measure did not reach the predefined response rate. However, because this is a small study without statistical comparison with the placebo group, the efficacy and safety of eculizumab could be investigated in larger, randomised controlled trials. Funding: The Japan Agency for Medical Research and Development, Ministry of Health, Labor and Welfare, and Alexion Pharmaceuticals.

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Effectiveness of a cognitive behavioural therapy-based anxiety prevention programme at an elementary school in Japan: a quasi-experimental study

Urao, Yuko, Yoshida, Michiko, Koshiba, Takako, Sato, Yasunori, Ishikawa, Shin-ichi, Shimizu, Eiji

CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH (Child and Adolescent Psychiatry and Mental Health)  12 ( 1 ) 772 - 780 2018.06

Research paper (scientific journal), Joint Work,  ISSN  1753-2000

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© 2018 The Author(s). Background: The efficacy of cognitive behavioural therapy (CBT) for anxiety related problems in children is empirically supported. In addition, universal anxiety prevention programmes based on CBT have been demonstrated in recent years. The purpose of this study was to verify the effectiveness of a CBT based original programme 'Journey of the Brave,' aiming to prevent anxiety disorders and anxiety-related problems for Japanese children aged 10-12 years old. Methods: Intervention groups from two classes of 5th grade elementary students (n = 41) received ten 45-min programme sessions. The control group was drawn from one class of 5th grade children (n = 31) from a nearby school. All participants completed the Spence Children's Anxiety Scale (SCAS) at pre, post, and 3 months follow-up. Mixed-effects model for repeated measures analysis was conducted. Results: The mean anxiety score on the SCAS for the intervention group was significantly reduced at both post intervention and 3 months follow-up compared with the control group. The group differences on the SCAS from baseline to post-test were - 5.321 (95% CI - 10.12 to - 0.523, p = 0.030), and at the 3-month follow-up were - 7.104 (95% CI - 11.90 to - 2.306, p = 0.004). Conclusions: The effectiveness of the anxiety prevention programme 'Journey of the Brave' was verified though this study using a quasi-experimental design on a small sample. Trial registration: UMIN000009021

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【新生児外科-最近の話題】先天性横隔膜ヘルニアにおける栄養管理

照井 慶太, 臼井 規朗, 田附 裕子, 永田 公二, 伊藤 美春, 奥山 宏臣, 早川 昌弘, 田口 智章, 佐藤 泰憲, 吉田 英生

小児外科 ((株)東京医学社)  50 ( 6 ) 588 - 592 2018.06

ISSN  0385-6313

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日本先天性横隔膜ヘルニア(CDH)スタディグループ内の5施設で実施された栄養に関する追跡調査のデータを元に、CDH管理における急性期栄養が乳幼児期の成長に及ぼす影響について報告した。その結果、CDH軽症例では、積極的な経腸栄養(EN)が乳児期の体重増加に寄与することが示唆された。重症例では急性期におけるENが困難な場合が多く、静脈栄養によるサポートが体重増加に寄与する可能性が示唆された。

SLCO1B1 Polymorphism Is a Drug Response Predictive Marker for Advanced Pancreatic Cancer Patients Treated With Gemcitabine, S-1, or Gemcitabine Plus S-1

Sato, Y., Ueno, H., Ioka, T., Ohkawa, S., Ikeda, M., Shimamura, T., Tsuji, A., Tsuchiya, Y., Furuse, J., Ishii, H., Furuya, K., Iguchi, H., Saito, Y., Kaniwa, N., Sawada, J. I., Sakamoto, H., Sekine, A., Okusaka, T. and Yoshida, T.

Pancreas (Pancreas)  47 ( 5 ) 637 - 642 2018.05

Research paper (scientific journal), Joint Work,  ISSN  0885-3177

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OBJECTIVES: The aim of this study was to evaluate the effects of single-nucleotide polymorphisms (SNPs) on advanced pancreatic cancer risk and overall survival (OS) in a candidate-gene approach. METHODS: Overall, 5438 SNPs in 219 candidate genes encoding several drug-metabolizing enzymes or transporters were analyzed. In the screening study, 3 SNPs were found associated with OS (P </= 0.0005). We validated these SNPs as part of the randomized phase 3 study (GEST study). The associations between OS and SNPs were investigated using log-rank test and Cox proportional hazards model. RESULTS: From the GEST study, the SNP rs4149086 in the 3' UTR of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene showed significant interaction with treatment (P = 0.02). In the gemcitabine group, the SNP was associated with short OS (hazard ratio [HR], 3.75; 95% confidence interval [CI], 1.30-10.8; P = 0.008) even after multiple-comparisons adjustment. In contrast, the SNP was not associated with OS in S-1 (HR, 0.77; 95% CI, 0.33-1.81; P = 0.55) or gemcitabine plus S-1 groups (HR, 1.18; 95% CI, 0.46-3.00; P = 0.72). CONCLUSIONS: Patients with advanced pancreatic cancer with the rs4149086 AG or GG genotype may obtain good clinical results when treated with S-1-containing regimens.

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Adverse Event Reporting Patterns of Marketing Authorization Holders, Healthcare Professionals and Patients in Japan: Lessons Learnt From the Human Papilloma Virus Vaccine

Inokuma Y., Sato Y., Masuda S.

Pharmaceutical Medicine (Pharmaceutical Medicine)  32 ( 2 ) 123 - 129 2018.04

ISSN  11782595

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© 2018, Springer International Publishing AG, part of Springer Nature. Background: A patient organization was founded in 2013 due to skepticism about the safety of human papilloma virus (HPV) vaccines. Objective: To evaluate the impact of “priming” patients with information on adverse events following immunization (AEFI) via mainstream media and its impact on reporting by marketing authorization holders (MAHs), healthcare professionals (HCPs), and patients, and to assess the contribution of a pilot patient reporting system for adverse events in Japan to pharmacovigilance. Methods: A summary list of reports of anaphylaxis, vagal reflex, and generalized pain-related AEFI, as presented to the Vaccine Adverse Reactions Review Committee (VARRC) between 2011 and 2016, was analyzed to gain information on MAH and HCP reports. Data on patient AEFI reporting were obtained from a pilot Pharmaceuticals and Medical Devices Agency (PMDA) database designed for this purpose. Data on vaccine shipment volumes were obtained from the VARRC. Results: The leading reporting source transitioned from MAHs (82% of the total AEFI reported in 2010) to HCPs (63% in 2011), and patients (43% in 2015). Sharp peaks were observed for both MAH and HCP reports in 2011. A second peak in pain-related AEFIs reported by HCPs was observed in 2013 when the Ministry of Health, Labour and Welfare suspended the active recommendation of HPV vaccines. Patient reports were continuous and accounted for 21.7% of the total AEFIs reported to the current patient reporting system. Conclusion: In Japan, the characteristics of AEFI reports differed by source for HPV vaccines. MAH and HCP reports identified the major trend in AEFI occurrence during the early post-marketing phase, whereas patient reports in cooperation with HCPs facilitated the detection of weak signals of possible AEFIs throughout the product lifecycle. Patient reporting systems should be encouraged, especially by promoting the communication between patients and local “home” pharmacies in cooperation with patient organizations.

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Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers

Hoshina, Azusa, Kawamoto, Tatsuya, Sueta, Shin-Ichi, Mae, Shin-Ichi, Araoka, Toshikazu, Tanaka, Hiromi, Sato, Yasunori, Yamagishi, Yukiko, Osafune, Kenji

SCIENTIFIC REPORTS (Scientific Reports)  8 ( 1 ) 637 - 642 2018.04

Research paper (scientific journal), Joint Work,  ISSN  2045-2322

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© 2018 The Author(s). Cell therapy using renal progenitors differentiated from human embryonic stem cells (hESCs) or induced pluripotent stem cells (hiPSCs) has the potential to significantly reduce the number of patients receiving dialysis therapy. However, the differentiation cultures may contain undifferentiated or undesired cell types that cause unwanted side effects, such as neoplastic formation, when transplanted into a body. Moreover, the hESCs/iPSCs are often genetically modified in order to isolate the derived renal progenitors, hampering clinical applications. To establish an isolation method for renal progenitors induced from hESCs/iPSCs without genetic modifications, we screened antibodies against cell surface markers. We identified the combination of four markers, CD9-CD140a+CD140b+CD271+, which could enrich OSR1+SIX2+ renal progenitors. Furthermore, these isolated cells ameliorated renal injury in an acute kidney injury (AKI) mouse model when used for cell therapy. These cells could contribute to the development of hiPSC-based cell therapy and disease modeling against kidney diseases.

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Bronchoscopic assessment of bronchial anastomosis by visualizing local circulation status-index of hemoglobin (IHb) imaging

Yamamoto, Takayoshi, Yoshida, Shigetoshi, Nakajima, Takahiro, Fujiwara, Taiki, Suzuki, Hidemi, Iwata, Takekazu, Sato, Yasunori, Yoshino, Ichiro

JOURNAL OF THORACIC DISEASE (Journal of Thoracic Disease)  10 ( 4 ) 2196 - + 2018.04

Research paper (scientific journal), Joint Work,  ISSN  2072-1439

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© Journal of Thoracic Disease. Background: Healing of airway anastomosis is largely affected by local circulation. Index of hemoglobin (IHb) imaging is a color enhancement technique that clarifies local circulation in the gastrointestinal endoscopic field. In this study, we investigated the relationship between bronchoscopic assessment of bronchial anastomosis using IHb mode and occurrence of anastomosis-related complications. Methods: IHb was calculated by logarithmic transformation for each pixel of the electronic endoscopic images and expressed by colors of red, green, and blue. The distribution of each color area was automatically calculated by the summation of pixels. A preliminary experiment spraying vasodilator on swine was performed to confirm the relationship between bronchial mucosal circulation and the IHb image. Forty consecutive patients who underwent bronchoplasty were divided into retrospective training and prospective validation cohorts, and anastomosis-related complications and IHb images were analyzed. Results: The IHb images immediately and accurately reflected the mucosal changes in the animal experiment. Among 25 cases in the retrospective training cohort, 6 cases experienced complications, with significantly lower red and higher blue values in IHb observed (P=0.03 and P=0.01, respectively). A receiver operating characteristic (ROC) curve for IHb red and blue distributions revealed the thresholds to differentiate cases with complications as 89.2 and 109.0, respectively. An analysis of the prospective validation cohort revealed that IHb blue on POD 7 was a potentially reliable predictor of complications, with 60.0% sensitivity and 90.0% specificity. Conclusions: IHb mode of bronchoscopy may be useful for assessing the local circulatory condition of bronchoplasty, which can predict anastomosis-related morbidity.

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Prevalence and associated factors of foot and ankle pain among nurses at a university hospital in Japan: A cross-sectional study

Tojo, Maki, Yamaguchi, Satoshi, Amano, Naoko, Ito, Akemi, Futono, Machiko, Sato, Yasunori, Naka, Takako, Kimura, Seiji, Sadamasu, Aya, Akagi, Ryuichiro, Ohtori, Seiji

JOURNAL OF OCCUPATIONAL HEALTH (Journal of Occupational Health)  60 ( 2 ) 132 - 139 2018.03

Research paper (scientific journal), Joint Work,  ISSN  1341-9145

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© 2018 by the Japan Society for Occupational Health. Objectives: The purposes of this study were to clarify 1) the prevalence of foot and ankle pain and 2) the factors associated with foot and ankle pain among nurses. Methods: Nurses working at a university hospital in Japan were recruited to participate in this crosssectional, questionnaire-based study. The occurrence of foot and ankle pain in the previous month was assessed by using the Standardized Nordic Questionnaire and the Manchester Foot Pain and Disability Index. Subjects also answered questions on footwear-related factors, including using the visual analog scale for shoe comfort. In addition, information on personal factors and psychosocial factors was collected using the Job Content Questionnaire. The relationships between the presence of foot and ankle pain and the associated factors were examined using multiple logistic regression analysis. Results: Responses of 636 nurses (response rate, 67%) were included for analysis. The prevalence of foot and ankle pain was 23% and 51% when using the Standardized Nordic Questionnaire and the Manchester Foot Pain and Disability Index, respectively. The prevalence of pain that prevented the nurses from performing activities of daily living and work was 4% and 17%, respectively. A low level of shoe comfort, personal factors (age and body mass index), and psychosocial factors (low job control and high job strain) was independently associated with the presence of foot and ankle pain. Conclusions: Foot and ankle pain occurred frequently in nurses. Shoe comfort, personal factors, and psychosocial factors were associated with foot and ankle pain.

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Impact of initial aortic diameter and false-lumen area ratio on Type B aortic dissection prognosis

Matsushita, Akihito, Hattori, Takashi, Tsunoda, Yu, Sato, Yasunori, Mihara, Andwahei

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (Interactive Cardiovascular and Thoracic Surgery)  26 ( 2 ) 176 - 182 2018.02

Research paper (scientific journal), Joint Work,  ISSN  1569-9293

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© 2017 The Author. OBJECTIVES: Medical treatment is the gold standard for uncomplicated acute Type B aortic dissection (ATBAD). Although endovascular treatment could become an alternative therapy, it is unclear which ATBAD patients should undergo endovascular intervention. We aimed to evaluate the outcomes of patients with uncomplicated ATBAD and identify the risk factors for major adverse events. METHODS: We retrospectively reviewed 134 consecutive patients who underwent initial treatment for uncomplicated ATBAD between 2004 and 2015. Follow-up rate was 98.5%, and the median follow-up period was 47 months. We evaluated the incidence of major adverse events (aortic-related death, aortic surgery and dilated aorta >55 mm) and identified the predictors of major adverse events using multivariable analysis. RESULTS: In-hospital mortality rate was 0.7% (1/134). During follow-up, 46 patients had major adverse events. The 1-, 3-, and 5-year rates of freedom from major adverse events were 79.8%, 71.4%, and 63.6%, respectively. The independent risk factors for major adverse events were initial aortic diameter <40mm (hazard ratio 3.735, 95% confidence interval 1.888-7.390; P < 0.001) and false-lumen diameter < truelumen diameter (hazard ratio 3.411, 95% confidence interval 1.491-7.806; P = 0.004). CONCLUSIONS: Initial aortic diameter <40mm and false-lumen diameter < true-lumen diameter are predictors of major adverse events after uncomplicated ATBAD. Patients with these risk factors may benefit from early endovascular intervention. Clinical registration number: UMIN 000025388, https://upload.umin.ac.jp/cgi-open-bin/ctr-e/ctr-view.cgi?recptno=R000029229.

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Development of Adherence Questionnaire for Children and Adolescents with Asthma

Fujisawa, Takao, Nagao, Mizuho, Mizuno, Yumi, Shimojo, Naoki, Itoh-Nagato, Natoka, Ohya, Yukihiro, Imai, Takanori, Ebisawa, Motohiro, Habukawa, Chizu, Odajima, Hiroshi, Sato, Yasunori

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 141 ( 2 ) AB222 - AB222 2018.02

Research paper (scientific journal), Joint Work,  ISSN  0091-6749

"Spike" in acute asthma exacerbations during enterovirus D68 epidemic in Japan: A nation-wide survey

Korematsu, Seigo, Nagashima, Kengo, Sato, Yasunori, Nagao, Mizuho, Hasegawa, Shunji, Nakamura, Haruna, Sugiura, Shiro, Miura, Katsushi, Okada, Kenji, Fujisawa, Takao

ALLERGOLOGY INTERNATIONAL (Allergology International)  67 ( 1 ) 55 - 60 2018.01

Research paper (scientific journal), Joint Work,  ISSN  1323-8930

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© 2017 Japanese Society of Allergology Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.

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Randomised controlled trial on the effect of internet-delivered computerised cognitive-behavioural therapy on patients with insomnia who remain symptomatic following hypnotics: a study protocol

Sato, Daisuke, Yoshinaga, Naoki, Nagai, Eiichi, Hanaoka, Hideki, Sato, Yasunori, Shimizu, Eiji

BMJ OPEN (BMJ Open)  8 ( 1 ) 199 - 205 2018.01

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Insomnia has severe consequences for health. Primary care physicians in Japan commonly provide hypnotics, which is far from optimal. The recommended treatment for insomnia is cognitive-behavioural therapy (CBT). Access to trained therapists, however, is limited. Rather than face-to-face CBT, several researchers have studied internet-delivered computerised CBT (ICBT). This paper describes the study protocol for a randomised controlled trial (RCT) to evaluate effectiveness and feasibility of our newly developed five-step ICBT as an adjunct to usual care (UC) compared with UC alone for patients with insomnia who remain symptomatic following hypnotics. Methods and analysis This proposed exploratory RCT comprises two parallel groups (ICBT+UC and UC alone) consisting of 15 participants each (n=30) diagnosed with insomnia who remain symptomatic after pharmacotherapy. We aim to evaluate the effectiveness of six intervention weeks. The primary outcome of insomnia severity will be the Pittsburgh Sleep Quality Index (PSQI) at week 6. Secondary outcomes include sleep onset latency, total sleep time, sleep efficiency extracted from PSQI, current feeling of refreshment and perceived soundness of sleep measured using visual analogue scale, number of awakenings, anxiety by Hospital Anxiety and Depression Scale, depression by Center for Epidemiologic Studies Depression Scale and quality of life by Euro Qol-5D. All measures will be assessed at weeks 0 (baseline), 6 (postintervention) and 12 (follow-up), and intention-to-treat analysis will be applied. The statistical analysis plan has been developed considering design of field materials. Ethics and dissemination This study will be conducted at the academic outpatient clinic of Chiba University Hospital, Japan. Ethics approval was granted by the Institutional Review Board of Chiba University Hospital. All participants will be required to provide written informed consent. The trial will be implemented and reported in accordance with Consolidated Standards of Reporting Trials recommendations. Trial registration number UMIN000021509; Pre-results.

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Dynamic behaviour of the soft palate during nasal positive pressure ventilation under anaesthesia and paralysis: comparison between patients with and without obstructive sleep-disordered breathing

Okuyama M., Kato S., Sato S., Okazaki J., Kitamura Y., Ishikawa T., Sato Y., Isono S.

British Journal of Anaesthesia (British Journal of Anaesthesia)  120 ( 1 ) 181 - 187 2018.01

ISSN  00070912

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© 2017 Background: Difficult mask ventilation is common and is known to be associated with sleep-disordered breathing (SDB). It is our hypothesis that the incidence of expiratory retropalatal (RP) airway closure (primary outcome) during nasal positive pressure ventilation (PPV) is more frequent in patients with SDB (apnea hypopnea index ≥5 h −1 ) than non-SDB subjects. Methods: The severity of SDB was assessed before surgery using a portable sleep monitor. In anaesthetized and paralysed patients with (n=11) and without SDB (n=9), we observed the behaviour of the RP airway endoscopically during nasal PPV with the mouth closed and determined the dynamic RP closing pressure, which was defined as the highest airway pressure above which the RP airway closure was reversed. The static RP closing pressure was obtained during cessation of mechanical ventilation in patients with dynamic RP closure during nasal PPV. Results: The expiratory RP airway closure accompanied by expiratory flow limitation occurred more frequently in SDB patients (9/11, 82%) than in non-SDB subjects (2/9, 22%; exact logistic regression analysis: P=0.022, odds ratio 3.6, 95% confidence interval 1.1–15.4). Receiver operating characteristic curve analyses indicated AHI >10h −1 and presence of habitual snoring as clinically useful predictors for the occurrence of RP closure during PPV. Dynamic RP closing pressure was greater than the static RP closing pressure by approximately 4–5 cm H 2 O. Conclusions: Valve-like dynamic RP closure that limits expiratory flow during nasal PPV occurs more frequently in SDB patients.

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The prognostic significance of vasohibin-2 expression in patients with prostate cancer

Miyazaki Yasumasa, Kosaka Takeo, Mikami Shuji, Yasumizu Yota, Tanaka Nobuyuki, Kikuchi Eiji, Sato Yasufumi, Oya Mototsugu

CANCER SCIENCE 109   1070 - 1070 2018.01

ISSN  1349-7006

Non-Radiographic Measurement of Hallux Valgus Angle Using Self-Photography.

Yamaguchi S, Sadamasu A, Kimura S, Akagi R, Yamamoto Y, Sato Y, Sasho T, Ohtori S

J Orthop Sports Phys Ther (Journal of Orthopaedic and Sports Physical Therapy)  in press ( 2 ) 80 - 86 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  01906011

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Copyright ©2019 Journal of Orthopaedic & Sports Physical Therapy. BACKGROUND: Radiographs of the feet are the reference standard for measuring the hallux valgus angle. However, the availability and use of radiographs are constrained due to cost and radiation exposure. Less invasive, nonradiographic assessments have been proposed, although measurement using self-photography has not been reported. t OBJECTIVES: To determine (1) reliability of photographic hallux valgus angle (pHVA) measurement using the same photographs of the feet, (2) reliability of repeated self-photography trials, and (3) measurement error when the radiographic hallux valgus angle (rHVA) is estimated using the pHVA. t METHODS: In this reliability study, participants took photographs of their own feet using a digital camera. The intrarater and interrater reliability of pHVA measurements were then assessed using the intraclass correlation coefficient (ICC) and 95% minimum detectable change (MDC). The participants took photographs twice, and the reliability of repeated self-photography trials was examined. Participants also received radiographs of their feet, from which the rHVA was measured. The measurement error was assessed using the mean difference and 95% limits of agreement. t RESULTS: The intrarater and interrater ICC of pHVA measurement was 0.99, with MDCs less tha 2°. The ICC of pHVA measurement for repeated self-photography was 0.96, and the MDC was 6.9° The pHVA was systematically lower than the rHVA by 5.3°. t CONCLUSION: Measurement of the pHVA using self-photography was reproducible, althoug pHVA measurement underestimated the rHVA. Th pHVA can be a useful nonradiographic method to uantify hallux valgus deformity.

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Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses' Health Study (JNHS)

Alkebsi, Lobna, Ideno, Yuki, Lee, Jung-Su, Suzuki, Shosuke, Nakajima-Shimada, Junko, Ohnishi, Hiroshi, Sato, Yasunori, Hayashi, Kunihiko

JOURNAL OF EPIDEMIOLOGY (Journal of Epidemiology)  28 ( 1 ) 34 - 40 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0917-5040

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© © 2017 Lobna Alkebsi et al. Background: Although several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019). Methods: The impact of the ABO blood group on GDU risk was examined using Cox regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CI), with adjustment for potential confounders. Results: Compared with women with non-O blood types (A, B, and AB), women with blood type O had a significantly increased risk of GDU from birth (multivariable-adjusted HR 1.18; 95% CI, 1.04–1.34). Moreover, the highest cumulative incidence of GDU was observed in women born pre-1956 with blood type O. In a subgroup analysis stratified by birth year (pre-1956 or post-1955), the multivariable-adjusted HR of women with blood type O was 1.22 (95% CI, 1.00–1.49) and 1.15 (95% CI, 0.98–1.35) in the pre-1956 and post-1955 groups, respectively. Conclusion: In this large, combined, ambispective cohort study of Japanese women, older women with blood type O had a higher risk of developing GDU than those with other blood types.

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Internet-Based Cognitive Behavioral Therapy With Real-Time Therapist Support via Videoconference for Patients With Obsessive-Compulsive Disorder, Panic Disorder, and Social Anxiety Disorder: Pilot Single-Arm Trial

Matsumoto K, Sutoh C, Asano K, Seki Y, Urao Y, Yokoo M, Takanashi R, Yoshida T, Tanaka M, Noguchi R, Nagata S, Oshiro K, Numata N, Hirose M, Yoshimura K, Nagai K, Sato Y, Kishimoto T, Nakagawa A, Shimizu E.

J Med Internet Res (Journal of Medical Internet Research)  20 ( 12 ) e12091 2018

Research paper (scientific journal), Joint Work, Accepted

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© 2018 Journal of Medical Internet Research. All rights reserved. Background: Cognitive behavioral therapy (CBT) is the first-line treatment for adults with obsessive-compulsive disorder (OCD), panic disorder (PD), and social anxiety disorder (SAD). Patients in rural areas can access CBT via the internet. The effectiveness of internet-delivered cognitive behavioral therapy (ICBT) has been consistently shown, but no clinical studies have demonstrated the feasibility of ICBT with real-time therapist support via videoconference for OCD, PD, and SAD at the same time. Objectives: This study aimed to evaluate the feasibility of videoconference-delivered CBT for patients with OCD, PD, or SAD. Methods: A total of 30 Japanese participants (mean age 35.4 years, SD 9.2) with OCD, SAD, or PD received 16 sessions of individualized videoconference-delivered CBT with real-time support of a therapist, using tablet personal computer (Apple iPad Mini 2). Treatment involved individualized CBT formulations specific to the presenting diagnosis; all sessions were provided by the same therapist. The primary outcomes were reduction in symptomatology, using the Yale-Brown obsessive-compulsive scale (Y-BOCS) for OCD, Panic Disorder Severity Scale (PDSS) for PD, and Liebowitz Social Anxiety Scale (LSAS) for SAD. The secondary outcomes included the EuroQol-5 Dimension (EQ-5D) for Quality of Life, the Patient Health Questionnaire (PHQ-9) for depression, the Generalized Anxiety Disorder (GAD-7) questionnaire for anxiety, and Working Alliance Inventory-Short Form (WAI-SF). All primary outcomes were assessed at baseline and at weeks 1 (baseline), 8 (midintervention), and 16 (postintervention) face-to-face during therapy. The occurrence of adverse events was observed after each session. For the primary analysis comparing between pre- and posttreatments, the participants' points and 95% CIs were estimated by the paired t tests with the change between pre- and posttreatment. Results: A significant reduction in symptom of obsession-compulsion (Y-BOCS=-6.2; Cohen d=0.74; 95% CI -9.4 to -3.0, P=.002), panic (PDSS=-5.6; Cohen d=0.89; 95% CI -9.83 to -1.37; P=.02), social anxiety (LSAS=-33.6; Cohen d=1.10; 95% CI -59.62 to -7.49, P=.02) were observed. In addition, depression (PHQ-9=-1.72; Cohen d=0.27; 95% CI -3.26 to -0.19; P=.03) and general anxiety (GAD-7=-3.03; Cohen d=0.61; 95% CI -4.57 to -1.49, P<.001) were significantly improved. Although there were no significant changes at 16 weeks from baseline in EQ-5D (0.0336; Cohen d=-0.202; 95% CI -0.0198 to 0.00869; P=.21), there were high therapeutic alliance (ie, WAI-SF) scores (from 68.0 to 73.7) throughout treatment, which significantly increased (4.14; 95% CI 1.24 to 7.04; P=.007). Of the participants, 86% (25/29) were satisfied with videoconference-delivered CBT, and 83% (24/29) preferred videoconference-delivered CBT to face-to-face CBT. An adverse event occurred to a patient with SAD; the incidence was 3% (1/30). Conclusions: Videoconference-delivered CBT for patients with OCD, SAD, and SAD may be feasible and acceptable.

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Genomic Comparison With Supercentenarians Identifies RNF213 as a Risk Gene for Pulmonary Arterial Hypertension

174. Suzuki H, Kataoka M, Hiraide T, Aimi Y, Yamada Y, Katsumata Y, Chiba T, Kanekura K, Isobe S, Sato Y, Satoh T, Gamou S, Fukuda K, Kosaki K

Circ Genom Precis Med 11 ( 12 ) e002317 2018

Research paper (scientific journal), Joint Work, Accepted

Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial

173. Miyakawa A, Kodera S, Sakuma Y, Shimada T, Kubota M, Nakamura A, Itobayashi E, Shimura H, Suzuki Y, Sato Y, Shimura K

Digestion  2018

Research paper (scientific journal), Joint Work, Accepted

Efficacy of foot orthoses as nonoperative treatment for hallux valgus: A 2-year follow-up study

Nakagawa R, Yamaguchi S, Kimura S, Sadamasu A, Yamamoto Y, Muramatsu Y, Sato Y, Akagi R, Sasho T, Ohtori S.

J Orthop Sci (Journal of Orthopaedic Science)  24 ( 3 ) 526 - 531 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  09492658

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© 2018 Background: The purpose of this study was to clarify the 2-year clinical and radiological outcomes of nonoperative treatment using foot orthosis for hallux valgus patients. Methods: Patients who underwent nonoperative treatment using foot orthosis were surveyed prospectively. Foot orthoses were made by one certified orthotist using the standardized method. Pain and quality of life were evaluated using subjective and objective assessment measures at 3, 6, 12, 18, and 24 months. Furthermore, radiological outcomes, patient satisfaction, and adherence to treatment were surveyed. Results: A total of 53 patients (50 women and 3 men; median age, 63 years) were included for analysis. The pain visual analogue scale score significantly decreased over time, with the lowest score observed at 12 months. The treatment effect was maintained over 24 months (median score, 52, 21, and 27 points at baseline, 12 months, and 24 months, respectively; P < .001). The Japanese Society for Surgery of the Foot hallux scale, American Academy of Orthopaedic Surgeons Foot and Ankle Scale, and 36-Item Short-Form Health Survey bodily pain subscale also improved, although the treatment effects were maximal at 6 months and decreased thereafter. At 24 months, 43 (81%) patients continued to use the orthosis, with the median visual analogue scale score for patient satisfaction of 76 points. The hallux valgus angle and intermetatarsal angle did not change during the 24-month period. Conclusion: Nonoperative treatment using foot orthoses decreased pain in patients with hallux valgus. The effect of treatment was maintained up to 2 years with a relatively high degree of patient satisfaction. However, treating physicians should inform patients to set realistic expectations and be aware that a limited degree of pain reduction is expected.

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Complications after stereotactic radiosurgery for brain metastases: Incidences, correlating factors, treatments and outcomes

168. Aiyama H, Yamamoto M, Kawabe T, Watanabe S, Koiso T, Sato Y, Higuchi Y, Ishikawa E, Yamamoto T, Matsumura A, Kasuya H, Barfod BE

Radiother Oncol (Radiotherapy and Oncology)  129 ( 2 ) 103 - 110 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  01678140

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© 2018 Elsevier B.V. Background and purpose: Complications after stereotactic radiosurgery (SRS) for brain metastases (BMs) were analyzed in detail using our database including nearly 3000 BM patients. Materials and methods: This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 3271 consecutive patients who underwent gamma knife SRS for BMs during the 1998–2016 period. Excluding four patients lost to follow-up, 112 with three-staged treatment and 189 with post-operative irradiation, 2966 who underwent a single-session of SRS only as radical irradiation were studied. Results: The overall median survival time after SRS was 7.8 (95% CI; 7.4–8.1) months. Post-SRS complications occurred in 86 patients (2.9%) 1.9–211.4 (median; 24.0, IQR; 12.0–64.6) months after treatment. RTOG neurotoxicity grades were 2, 3 and 4 in 58, 25 and 3 patients, respectively. Cumulative incidences determined with a competing risk analysis were 1.4%, 2.2%, 2.4%, 2.6% and 2.9% at the 12th, 24th, 36th, 48th and 60th post-SRS month, respectively. Among various pre-SRS clinical factors and radiosurgical parameters, multivariable analyses demonstrated solitary tumor (Adjusted HR; 0.584, 95% CI; 0.381–0.894, p = 0.0133), controlled primary cancer (Adjusted HR; 2.595, 95% CI; 1.646–4.091, p < 0.0001), no extra-cerebral metastases (Adjusted HR; 1.608, 95% CI; 1.028–2.514, p = 0.0374), KPS ≥80% (Adjusted HR; 2.715, 95% CI; 1.245–5.924, p = 0.0121) and largest tumor volume ≥3.3 cc (Adjusted HR; 0.516, 95% CI; 0.318–0.836, p = 0.0072) to be independently significant predictors of a higher incidence of complications. Conclusion: The post-SRS complication incidence is acceptably low (2.9%). Meticulous long-term follow-up after SRS is crucial for all patients.

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Comparison of treatment results between 3- and 2-stage Gamma Knife radiosurgery for large brain metastases: a retrospective multi-institutional study

Serizawa T, Higuchi Y, Yamamoto M, Matsunaga S, Nagano O, Sato Y, Aoyagi K, Yomo S, Koiso T, Hasegawa T, Nakazaki K, Moriki A, Kondoh T, Nagatomo Y, Okamoto H, Kohda Y, Kawai H, Shidoh S, Shibazaki T, Onoue S, Kenai H, Inoue A, Mori H

J Neurosurg    1 - 11 2018

Research paper (scientific journal), Joint Work, Accepted

Survey of Anticonvulsant Drugs and Lithium Prescription in Women of Childbearing age in Japan Using a Public National Insurance Claims Database

Yoshimura Kensuke, Hashimoto Tasuku, Sato Yasunori, Sato Aiko, Takeuchi Takashi, Watanabe Hiroyuki, Terao Takeshi, Nakazato Michiko, Iyo Masaomi

Clinical Neuropsychopharmacology and Therapeutics (日本臨床精神神経薬理学会)  9 ( 0 ) 20 - 28 2018

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<p>Purpose: Pharmacological treatments with some anticonvulsants, including valproate, and lithium should be avoided where possible in childbearing-aged and pregnant women with epilepsy and bipolar disorder because they increase the risk of major congenital malformations. We surveilled real-world prescriptions of anticonvulsants and lithium in childbearing-aged female and male outpatients in Japan, using the first public National Insurance Claims Database of Japan.</p><p>Methods: We performed a summary statistical analysis of the numbers of the most prescribed 11 anticonvulsants and lithium tablets in female and male outpatients aged 15-29 (younger childbearing age), 30-49 (older childbearing age), and >50 (non-childbearing age) years from April 2014 to March 2015. We determined the association between anticonvulsant or lithium use and sex at childbearing age, and the odds ratio (OR) and 95% confidence intervals (CIs) were estimated using logistic regression analysis.</p><p>Results: Valproate (number of tablets = 273,135,937) was the most prescribed among the 12 investigated drugs, and 125,451,907 tablets were prescribed for women (younger, older, and non-childbearing ages, 19,296,528, 47,826,746, and 58,328,63, respectively), compared to 147,684,031 tablets for men (24,534,648, 57,229,981, and 65,919,402, respectively). Valproate prescription was only slightly lower in childbearing-aged women than in the same-aged men (i.e., 15-29 years of age, OR = 0.889 [95% CI, 0.888-0.890]; 30-49 years of age, OR = 0.944 [95% CI, 0.944-0.945]).</p><p>Discussion: This study demonstrated valproate was highly prescribed for childbearing-aged women in Japan in 2014-2015. Physicians should prescribe valproate with considerable caution in girls and childbearing-aged women.</p>

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Association of locomotive syndrome with present and past physical activities, and self-reported gait speed: A cross sectional study

Yamaguchi S., Kishida S., Yamazaki N., Sato Y., Shirai T., Akagi R., Sasho T., Ohtori S., Takahashi K.

Chiba Medical Journal (Chiba Medical Journal)  94E   9 - 17 2018

ISSN  03035476

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The purpose of this study was to clarify the association of locomotive syndrome with present and past physical activities, as well as gait speed. Subjects were recruited from the participants of the specific health checkups in Oamishirasato City. The presence of locomotive syndrome was assessed using the stand-up test, two-step test, and 25-question geriatric locomotive function scale. Present physical activity was measured using the International Physical Activity Questionnaire. Questionnaires were also used to assess past physical activity and usual gait speed. The association of each locomotive syndrome risk test with the physical activities and gait speed was examined using univariate analysis and multiple logistic regression analysis. A total of 172 subjects with a mean age of 67.5 years were enrolled. Sixty-nine（40%）and 13（8%）subjects were classified as having stage 1 and 2 locomotive syndrome, respectively. Among the four groups classified by physical activity level, the proportions of subjects with positive stand-up test were higher in the groups of lowest and highest physical activity（P＝0.048）. Faster gait speed was a significant predictor of the negative two-step test（P＝0.08）, negative 25-question geriatric locomotive function scale（P＜0.001）, and absence of locomotive syndrome（P＝0.002）. The associations remained significant in the multiple regression analysis, after adjusting for age, sex, and body mass index. In conclusion, present physical activity was associated with the stand-up test, whereas self-reported usual gait speed was associated with the two-step test and 25-question geriatric locomotive function scale.

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Predictors of primary lung cancer in a solitary pulmonary lesion after a previous malignancy

Nakadate, A., Nakadate, M., Sato, Y., Nakagawa, T., Yoshida, K., Suzuki, Y. and Yoshida, Y.

Gen Thorac Cardiovasc Surg 65 ( 12 ) 698 - 704 2017.12

Research paper (scientific journal), Joint Work,  ISSN  1863-6705

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OBJECTIVE: A solitary pulmonary lesion in patients with a history of malignancy may be either primary lung cancer or a metastatic lung tumor or benign nodule. We retrospectively examined the preoperative predictive factors for determining the type of pathology. METHODS: We used an exact logistic regression analysis to identify radiological and clinical predictors of primary lung cancer. The study included 187 patients who underwent pulmonary resection for a solitary pulmonary lesion and had received previous treatment for a malignancy. RESULTS: There were 107 patients with primary lung cancer, 74 with metastatic lung tumors, and 6 with benign lesions. The previous malignancy included colorectal cancer in 71 patients. A disease-free interval exceeding 5 years and ground-glass opacity were found in 27.0% (20/74) and 1.4% (1/74) of metastatic lung tumors, respectively. Multivariate logistic regression analysis demonstrated that spiculation [adjusted odds ratio (a-OR), 1.74; 95% confidence interval (CI), 1.09-2.86], pleural indentation (a-OR 1.99, 95% CI 1.24-3.29), and ground-glass opacity (a-OR 5.28, 95% CI 2.61-13.1) on high-resolution computed tomography, maximum standardized uptake value (a-OR 1.14, 95% CI 1.02-1.29), current and former smokers (a-OR 1.96, 95% CI 1.21-3.30), and previous malignancy other than colorectal cancer (a-OR 2.02, 95% CI 1.26-3.37) were associated with primary lung cancer. CONCLUSIONS: A combination of radiological findings, smoking history, and type of previous malignancy can improve the ability to predict primary lung cancer in the presence of a solitary pulmonary lesion that appears after previous treatment for a malignancy.

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Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial

Furuta S, Sugiyama T, Umibe T, Kaneko Y, Amano K, Kurasawa K, Nakagomi D, Hanaoka H, Sato Y, Ikeda K, Nakajima H and on behalf of the LoVAS Trial study investigators

BMJ OPEN 7 ( 12 ) 55 - 60 2017.12

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Loose Lips Are Actually Good Reply

Isono, Shiroh, Sato, Shin, Hasegawa, Makoto, Okuyama, Megumi, Okazaki, Junko, Kitamura, Yuji, Sato, Yumi, Ishikawa, Teruhiko, Sato, Yasunori

ANESTHESIOLOGY 127 ( 5 ) 897 - 898 2017.11

Research paper (scientific journal), Joint Work,  ISSN  0003-3022

A clinical predictive score for postoperative myasthenic crisis

Kanai, Tetsuya, Uzawa, Akiyuki, Sato, Yasunori, Suzuki, Shigeaki, Kawaguchi, Naoki, Himuro, Keiichi, Oda, Fumiko, Ozawa, Yukiko, Nakahara, Jin, Suzuki, Norihiro, Takahashi, Yuko K., Ishibashi, Satoru, Yokota, Takanori, Ogawa, Takashi, Yokoyama, Kazumasa, Hattori, Nobutaka, Izaki, Shoko, Oji, Satoru, Nomura, Kyoichi, Kaneko, Juntaro, Nishiyama, Kazutoshi, Yoshino, Ichiro, Kuwabara, Satoshi

ANNALS OF NEUROLOGY 82 ( 5 ) 841 - 849 2017.11

Research paper (scientific journal), Joint Work,  ISSN  0364-5134

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Current Status and Open Issues Concerning Global Clinical Trials (GCTs) in Japan and East Asia

Miyazaki, Koichi, Sato, Yasunori, Hanaoka, Hideki, Uyama, Yoshiaki

CTS-CLINICAL AND TRANSLATIONAL SCIENCE 10 ( 6 ) 503 - 508 2017.11

Research paper (scientific journal), Joint Work,  ISSN  1752-8054

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Association of Anxiety and Depression With Pain and Quality of Life in Patients With Chronic Foot and Ankle Diseases

Nakagawa, Ryosuke, Yamaguchi, Satoshi, Kimura, Seiji, Sadamasu, Aya, Yamamoto, Yohei, Sato, Yasunori, Akagi, Ryuichiro, Sasho, Takahisa, Ohtori, Seiji

FOOT & ANKLE INTERNATIONAL 38 ( 11 ) 1192 - 1198 2017.11

Research paper (scientific journal), Joint Work,  ISSN  1071-1007

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Comparison of bias-corrected covariance estimators for MMRM analysis in longitudinal data with dropouts

Gosho, Masahiko, Hirakawa, Akihiro, Noma, Hisashi, Maruo, Kazushi, Sato, Yasunori

STATISTICAL METHODS IN MEDICAL RESEARCH 26 ( 5 ) 2389 - 2406 2017.10

Research paper (scientific journal), Joint Work,  ISSN  0962-2802

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Rationale, Design, and Baseline Characteristics of the Utopia Trial for Preventing Diabetic Atherosclerosis Using an SGLT2 Inhibitor: A Prospective, Randomized, Open-Label, Parallel-Group Comparative Study

SATO Yasunori

DIABETES THERAPY 8 ( 5 ) 999 - 1013 2017.10

Research paper (scientific journal),  ISSN  1869-6953

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Associations of three-dimensional T1 rho MR mapping and three-dimensional T2 mapping with macroscopic and histologic grading as a biomarker for early articular degeneration of knee cartilage

Sasho T., Katsuragi J., Yamaguchi S., Haneishi H., Aizimu T., Tanaka T., Watanabe A., Sato Y., Akagi R., Matsumoto K., Uno T., Motoori K.

Clinical Rheumatology (Clinical Rheumatology)  36 ( 9 ) 2109 - 2119 2017.09

ISSN  07703198

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© 2017, International League of Associations for Rheumatology (ILAR). T1 rho and T2 mapping are magnetic resonance imaging (MRI) techniques to detect early degenerative changes in cartilage. Recent advancements have enabled 3D acquisition for both techniques. The objective of the present study was to examine the correlation of 3D T1 rho and 3D T2 mapping with macroscopic and histological characteristics of knee cartilage. Twenty-one patients who underwent total knee arthroplasty due to osteoarthritis with involvement of the medial compartment but with minimum involvement of the lateral compartment were enrolled. Prior to surgery, five series of MRI were acquired with a 3-T scanner. 3D T1 rho/T2 analyses were performed following determination of regions to be assessed using in-house software that incorporated three series of MRI acquisitions data (3D-MERGE, 3D-SPGR, and 3D-CUBE). During surgery, the cartilage of the lateral compartment was macroscopically assessed with the International Cartilage Research Society (ICRS) articular classification system. The extracted specimens were histologically assessed using the OARSI histology score. Three regions of interest (ROI) were assessed for each slice (two slices per knee): the central lateral femoral condyle (cLFC), the posterior portion of the lateral femoral condyle (pLFC), and the lateral tibia plateau (LTP). For each ROI, the mean T1 rho and T2 relaxation time, the ICRS grade, and the OARSI score were compared. Neither the T1 rho nor the T2 reflected the macroscopic grading. The T1 rho could discriminate between histological grades 1 and 2. However, the T2 could not. The T1 rho relaxation time was higher in the pLFC than in the cLFC even in the same grade. Compared to T2 mapping, T1 rho mapping may have an advantage in differentiating grades I and II cartilage degeneration on OARSI histological grading system.

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Information criteria for Firth's penalized partial likelihood approach in Cox regression models

Nagashima, Kengo, Sato, Yasunori

STATISTICS IN MEDICINE 36 ( 21 ) 3422 - 3436 2017.09

Research paper (scientific journal), Joint Work,  ISSN  0277-6715

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A Multi-institutional Prospective Observational Study of Stereotactic Radiosurgery for Patients With Multiple Brain Metastases (JLGK0901 Study Update): Irradiation-related Complications and Long-term Maintenance of Mini-Mental State Examination Scores

Yamamoto, Masaaki, Serizawa, Toru, Higuchi, Yoshinori, Sato, Yasunori, Kawagishi, Jun, Yamanaka, Kazuhiro, Shuto, Takashi, Akabane, Atsuya, Jokura, Hidefumi, Yomo, Shoji, Nagano, Osamu, Aoyama, Hidefumi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 99 ( 1 ) 31 - 40 2017.09

Research paper (scientific journal), Joint Work,  ISSN  0360-3016

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A systematic approach to improve the outcomes of type A aortic dissection

Nishida, H., Tabata, M., Fukui, T., Sato, Y., Kin, H. and Takanashi, S.

J Thorac Cardiovasc Surg 154 ( 1 ) 89 - 96.e1 2017.07

Research paper (scientific journal), Joint Work,  ISSN  0022-5223

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OBJECTIVES: The aims of this study are to evaluate the outcomes and trends of contemporary emergency surgery for acute type A aortic dissection on the basis of a systematic approach and to assess the impact of temporary aortic crossclamping during systemic cooling on early and late outcomes. METHODS: We retrospectively reviewed 702 consecutive patients who underwent emergency surgery for acute type A aortic dissection between March 2004 and May 2015. Our clinical protocol includes rapid transfer to the operating room, quick establishment of cardiopulmonary bypass, temporary aortic crossclamping during cooling, primary entry resection, and open distal anastomosis. We analyzed the perioperative data, survival, freedom from aortic reinterventions, and impact of aortic crossclamping on early and late outcomes. RESULTS: The median time from hospital arrival to cardiopulmonary bypass establishment was 115 minutes and has decreased over the last decade (trend test P < .001). We perfused the femoral artery in 615 patients (87.6%), placed aortic crossclamping in 616 patients (87.7%), and performed open distal anastomosis in all patients. The operative mortality was 5.4% (38/702), and the incidence of stroke was 10.8% (76/702). The 7-year overall survival and freedom from aortic reinterventions were 80.4% and 87.5%, respectively. Compared with the nonclamping group, the crossclamping group had a shorter operation time, similar operative mortality, incidence of stroke, and freedom from aortic reinterventions. CONCLUSIONS: Emergency surgery for acute type A aortic dissection based on our systematic approach demonstrated excellent early and late outcomes. The temporary aortic crossclamping during cooling decreased the operation time without increasing early and late adverse events.

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Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study

Hashimoto, K., Ishima, T., Sato, Y., Bruno, D., Nierenberg, J., Marmar, C. R., Zetterberg, H., Blennow, K. and Pomara, N.

Sci Rep 7 ( 1 ) 3485 2017.06

Research paper (scientific journal), Joint Work,  ISSN  2045-2322

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Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD and age- and gender-matched healthy controls (N = 18). The CSF levels of 177 substances were measured, while 288 substances were below the detection limit. Only ascorbic acid was significantly different, with higher levels in the MDD group at baseline. There were no correlations between CSF ascorbic acid levels and clinical variables in MDD patients at baseline. At the 3-year follow-up, there was no difference of CSF ascorbic acid levels between the two groups. There was a negative correlation between CSF ascorbic acid and CSF amyloid-beta42 levels in all subjects. However, there were no correlations between ascorbic acid and other biomarkers (e.g., amyloid-beta40, total and phosphorylated tau protein). This preliminary study suggests that abnormalities in the transport and/or release of ascorbic acid might play a role in the pathogenesis of late-life depression.

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Impact of geographic accessibility on utilization of the annual health check-ups by income level in Japan: A multilevel analysis

Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

PLOS ONE 12 ( 5 ) 2389 - 2406 2017.05

Research paper (scientific journal), Joint Work,  ISSN  1932-6203

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Income-Related Inequalities in Access to Dental Care Services in Japan

Nishide, Akemi, Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 14 ( 5 ) 3422 - 3436 2017.05

Research paper (scientific journal), Joint Work,  ISSN  1660-4601

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Efficacy and safety of ipragliflozin and metformin for visceral fat reduction in patients with type 2 diabetes receiving treatment with dipeptidyl peptidase-4 inhibitors in Japan

Koshizaka M, Ishikawa K, Ishikawa T, Kobayashi K, Takemoto M, Horikoshi T, Shimousa R, Takahashi S, Nagashima K, Sato Y, Tatsuno I, Terano T, Hashimoto N, Kuribayashi N, Uchida D, Yokote K

BMJ OPEN 7 ( 5 ) 3422 - 3436 2017.05

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Usefulness of antigen-specific IgE probability curves derived from the 3gAllergy assay in diagnosing egg, cow's milk, and wheat allergies

Sato, Sakura, Ogura, Kiyotake, Takahashi, Kyohei, Sato, Yasunori, Yanagida, Noriyuki, Ebisawa, Motohiro

ALLERGOLOGY INTERNATIONAL 66 ( 2 ) 296 - 301 2017.04

Research paper (scientific journal), Joint Work,  ISSN  1323-8930

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Rationale and design of a multicenter placebo-controlled double-blind randomized trial to evaluate the effect of empagliflozin on endothelial function: the EMBLEM trial

Tanaka A, Shimabukuro M, Okada Y, Taguchi I, Yamaoka-Tojo M, Tomiyama H, Teragawa H, Sugiyama S, Yoshida H, Sato Y, Kawaguchi A, Ikehara Y, Machii N, Maruhashi T, Shima KR, Takamura T, Matsuzawa Y, Kimura K, Sakuma M, Oyama JI, Inoue T, Higashi Y, Ueda S, Node K

CARDIOVASCULAR DIABETOLOGY 16   2389 - 2406 2017.04

Research paper (scientific journal), Joint Work,  ISSN  1475-2840

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Statistical Methods in the Journal - An Update

Sato, Yasunori, Gosho, Masahiko, Nagashima, Kengo, Takahashi, Sho, Ware, James H., Laird, Nan M.

NEW ENGLAND JOURNAL OF MEDICINE 376 ( 11 ) 1086 - 1087 2017.03

Research paper (scientific journal), Joint Work,  ISSN  0028-4793

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Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders

Matsumoto, Junko, Hirano, Yoshiyuki, Hashimoto, Kenji, Ishima, Tamaki, Kanahara, Nobuhisa, Niitsu, Tomihisa, Shiina, Akihiro, Hashimoto, Tasuku, Sato, Yasunori, Yokote, Koutaro, Murano, Shunichi, Kimura, Hiroshi, Hosoda, Yutaka, Shimizu, Eiji, Iyo, Masaomi, Nakazato, Michiko

PSYCHIATRY AND CLINICAL NEUROSCIENCES 71 ( 2 ) 124 - 134 2017.02

Research paper (scientific journal), Joint Work,  ISSN  1323-1316

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Mask Ventilation during Induction of General Anesthesia

Sato S., Hasegawa M., Okuyama M., Okazaki J., Kitamura Y., Sato Y., Ishikawa T., Sato Y., Isono S.

Anesthesiology (Anesthesiology)  126 ( 1 ) 28 - 38 2017.01

ISSN  00033022

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© 2016 the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc. All Rights Reserved. Background: Depending on upper airway patency during anesthesia induction, tidal volume achieved by mask ventilation may vary. In 80 adult patients undergoing general anesthesia, the authors tested a hypothesis that tidal volume during mask ventilation is smaller in patients with sleep-disordered breathing priorly defined as apnea hypopnea index greater than 5 per hour. Methods: One-hand mask ventilation with a constant ventilator setting (pressure-controlled ventilation) was started 20 s after injection of rocuronium and maintained for 1 min during anesthesia induction. Mask ventilation efficiency was assessed by the breath number needed to initially exceed 5 ml/kg ideal body weight of expiratory tidal volume (primary outcome) and tidal volumes (secondary outcomes) during initial 15 breaths (UMIN000012494). Results: Tidal volume progressively increased by more than 70% in 1 min and did not differ between sleep-disordered breathing (n = 42) and non-sleep-disordered breathing (n = 38) patients. In post hoc subgroup analyses, the primary outcome breath number (mean [95% CI], 5.7 [4.1 to 7.3] vs. 1.7 [0.2 to 3.2] breath; P = 0.001) and mean tidal volume (6.5 [4.6 to 8.3] vs. 9.6 [7.7 to 11.4] ml/kg ideal body weight; P = 0.032) were significantly smaller in 20 sleep-disordered breathing patients with higher apnea hypopnea index (median [25th to 75th percentile]: 21.7 [17.6 to 31] per hour) than in 20 non-sleep disordered breathing subjects with lower apnea hypopnea index (1.0 [0.3 to 1.5] per hour). Obesity and occurrence of expiratory flow limitation during one-hand mask ventilation independently explained the reduction of efficiency of mask ventilation, while the use of two hands effectively normalized inefficient mask ventilation during one-hand mask ventilation. Conclusions: One-hand mask ventilation is difficult in patients with obesity and severe sleep-disordered breathing particularly when expiratory flow limitation occurs during mask ventilation.

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Mask Ventilation during Induction of General Anesthesia Influences of Obstructive Sleep Apnea

Sato, Shin, Hasegawa, Makoto, Okuyama, Megumi, Okazaki, Junko, Kitamura, Yuji, Sato, Yumi, Ishikawa, Teruhiko, Sato, Yasunori, Isono, Shiroh

ANESTHESIOLOGY 126 ( 1 ) 28 - 38 2017.01

Research paper (scientific journal), Joint Work,  ISSN  0003-3022

A case-matched study of stereotactic radiosurgery for patients with brain metastases: comparing treatment results for those with versus without neurological symptoms

Koiso, T., Yamamoto, M., Kawabe, T., Watanabe, S., Sato, Y., Higuchi, Y., Yamamoto, T., Matsumura, A., Kasuya, H. and Barfod, B. E.

J Neurooncol 130 ( 3 ) 581 - 590 2016.12

Joint Work,  ISSN  0167-594

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We aimed to reappraise whether post-stereotactic radiosurgery (SRS) results for brain metastases differ between patients with and without neurological symptoms. This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 2825 consecutive BM patients undergoing gamma knife SRS alone during the 15-year period since July 1998. The 2825 patients were divided into two groups; neurologically asymptomatic [group A, 1374 patients (48.6 %)] and neurologically symptomatic [group B, 1451 (51.4 %)]. Because there was considerable bias in pre-SRS clinical factors between groups A and B, a case-matched study was conducted. Ultimately, 1644 patients (822 in each group) were selected. The standard Kaplan-Meier method was used to determine post-SRS survival. Competing risk analysis was applied to estimate cumulative incidences of neurological death, neurological deterioration, local recurrence, re-SRS for new lesions and SRS-induced complications. Post-SRS median survival times (MSTs) did not differ between the two groups; 7.8 months in group A versus 7.4 months in group B patients (HR 1.064, 95 % CI 0.963-1.177, p = 0.22). However, cumulative incidences of neurological death (HR 1.637, 95 % CI 1.174-2.281, p = 0.0036) and neurological deterioration (HR 1.425, 95 % CI 1.073-1.894, p = 0.014) were significantly lower in the group A than in the group B patients. Neurologically asymptomatic patients undergoing SRS for BM had better results than symptomatic patients in terms of both maintenance of good neurological state and prolonged neurological survival. Thus, we conclude that screening computed tomography/magnetic resonance imaging is highly beneficial for managing cancer patients.

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Gamma Knife radiosurgery for brain metastases from pulmonary large cell neuroendocrine carcinoma: a Japanese multi-institutional cooperative study (JLGK1401)

Kawabe, Takuya, Yamamoto, Masaaki, Sato, Yasunori, Yomo, Shoji, Kondoh, Takeshi, Nagano, Osamu, Serizawa, Toru, Tsugawa, Takahiko, Okamoto, Hisayo, Akabane, Atsuya, Aita, Kazuyasu, Sato, Manabu, Jokura, Hidefumi, Kawagishi, Jun, Shuto, Takashi, Kawai, Hideya, Moriki, Akihito, Kenai, Hiroyuki, Iwai, Yoshiyasu, Gondo, Masazumi, Hasegawa, Toshinori, Yasuda, Soichiro, Kikuchi, Yasuhiro, Nagatomo, Yasushi, Watanabe, Shinya, Hashimoto, Naoya

JOURNAL OF NEUROSURGERY 125   11 - 17 2016.12

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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Follow-up results of brain metastasis patients undergoing repeat Gamma Knife radiosurgery

Koiso, Takao, Yamamoto, Masaaki, Kawabe, Takuya, Watanabe, Shinya, Sato, Yasunori, Higuchi, Yoshinori, Yamamoto, Tetsuya, Matsumura, Akira, Kasuya, Hidetoshi

JOURNAL OF NEUROSURGERY 125   2 - 10 2016.12

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barre Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS)

Yamaguchi, N., Misawa, S., Sato, Y., Nagashima, K., Katayama, K., Sekiguchi, Y., Iwai, Y., Amino, H., Suichi, T., Yokota, T., Nishida, Y., Kohara, N., Hirata, K., Nishiyama, K., Yabe, I., Kaida, K. I., Suzuki, N., Nodera, H., Tsuji, S., Koike, H., Kira, J. I., Hanaoka, H., Kusunoki, S. and Kuwabara, S.

JMIR Res Protoc 5 ( 4 ) e210 2016.11

Research paper (scientific journal), Joint Work,  ISSN  1929-0748

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BACKGROUND: Guillain-Barre syndrome (GBS) is an immune-mediated neuropathy that causes acute flaccid paralysis. Immunoglobulin and plasma exchange are established treatments for GBS; however, a substantial number of patients, particularly those with severe disease, have poor recovery and residual deficits. Recent studies suggest that complement activation plays a pivotal role in GBS-associated axonal degeneration, and eculizumab is a humanized monoclonal antibody that specifically binds to complement component 5 and potently inhibits complement activation. OBJECTIVE: This clinical trial aims to evaluate the efficacy and safety of eculizumab, a humanized monoclonal antibody directed against complement component 5, for treatment of GBS. METHODS: The Japanese Eculizumab Trial for GBS (JET-GBS) is a prospective, multicenter, placebo-controlled, double-blind, randomized phase II study conducted at 13 tertiary neurology centers and is funded by the Japan Agency for Medical Research and Development. A total of 33 GBS patients unable to walk independently within 2 weeks from symptom onset (Hughes functional grade 3-5) were randomized at a 2:1 ratio to receive either intravenous eculizumab (900 mg/day) or placebo once weekly for 4 weeks, followed by 20 weeks of follow-up. The primary endpoint for efficacy is the proportion of patients who regain their ability to walk without aid at 4 weeks after the first dose of the study treatment, while primary safety outcomes are the incidence of adverse events and serious adverse events during the trial. RESULTS: Enrollment for the trial began in August 2015. This trial is still ongoing. All participants have been enrolled, and follow-up will be completed in October 2016. CONCLUSIONS: This study is the first to investigate the efficacy and safety of eculizumab for GBS. In case of a positive result, we will plan a phase III trial to investigate this issue in a larger number of patients. CLINICALTRIAL: UMIN Clinical Trials Registry UMIN 000018171; https:/upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function= brows&action=brows&type=summary&language=J&recptno=R000020978 (Archived by WebCite at http://www.webcitation.org/ 6lTiG8ltG). Clinical Trials.gov NCT02493725; https://clinicaltrials.gov/ct2/show/NCT02493725 (Archived by WebCite at http://www.webcitation.org/6lVJZXKSL).

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Quality of Life in Patients With Untreated and Symptomatic Hallux Valgus

Yamamoto, Yohei, Yamaguchi, Satoshi, Muramatsu, Yuta, Terakado, Atsushi, Sasho, Takahisa, Akagi, Ryuichiro, Endo, Jun, Sato, Yasunori, Takahashi, Kazuhisa

FOOT & ANKLE INTERNATIONAL 37 ( 11 ) 1171 - 1177 2016.11

Research paper (scientific journal), Joint Work,  ISSN  1071-1007

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Predictive values of egg-specific IgE by two commonly used assay systems for the diagnosis of egg allergy in young children: a prospective multicenter study

Furuya K., Nagao M., Sato Y., Ito S., Fujisawa T., Kainuma K., Hirayama J., Kuwabara Y., Ito T., Morimoto M., Yamashita A., Atsuta J., Tatsumoto C., Fukuie T., Yasuoka R., Ikeda M., Sugai K., Sekimoto K., Tokuda R., Katsunuma T., Watanabe M., Kojima H., Suehiro Y., Hiraguchi Y., Ebishima Y., Simodera S., Yoshino S., Sato S., Sato M., Hijikata T., Otani T., Mizuno T., Shimauchi Y., Kitamura T., Fujiwara M., Hiraba K., Tokuyama K., Morita E., Murasugi H., Ouchi K., Wakabayashi T., Ono S., Nakano H., Okahata H., Nakamura T., Yamashita Y., Tachimoto H., Otani Y., Sugimoto M., Mizuuchi H., Ubuka A.

Allergy: European Journal of Allergy and Clinical Immunology (Allergy: European Journal of Allergy and Clinical Immunology)  71 ( 10 ) 1435 - 1443 2016.10

ISSN  01054538

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© 2016 The Authors. Allergy Published by John Wiley & Sons Ltd. Background: Specific IgE (sIgE) is often used to predict oral food challenge (OFC) outcomes in food allergy, but interpretation of the results may vary depending on the assay method employed and the patient population tested. The aim of this study was to use two commercial assay systems to determine egg-sIgE values predictive of allergy within the most common populations treated at pediatric clinics. Methods: In a multicenter prospective study, 433 children with suspected or confirmed egg allergy underwent oral challenge (OFC) using cooked egg (CE) and raw egg (RE) powders to diagnose either true allergy in 1-year-old (group A, n = 220) or tolerance in 2- to 6-year-old (group B, n = 213). Egg white (EW)- and ovomucoid (OM)-sIgE values were measured using the ImmunoCAP® sIgE (ImmunoCAP) and the IMMULITE® 2000 3 gAllergy™ (3gAllergy) systems. Children were recruited from six primary care clinics and 18 hospitals in Japan. Results: Receiver-operating characteristic (ROC) curve analysis yielded similar areas under the curve (AUC) for the two assays (0.7–0.8). The optimal cutoff values and the probability curves (PCs) of the sIgE by the two assays to predict CE and RE OFC outcomes were determined for both groups. Values for 3gAllergy were higher than for ImmunoCAP; however, correlation of sIgE and predicted probability calculated by PCs were strong between the two methods. Conclusions: Cutoff values and PCs for egg-sIgE established using both ImmunoCAP and 3gAllergy may be useful for predicting egg allergy in early childhood patient populations.

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Safety and efficacy of thalidomide in patients with POEMS syndrome: a multicentre, randomised, double-blind, placebo-controlled trial

Misawa S, Sato Y, Katayama K, Nagashima K, Aoyagi R, Sekiguchi Y, Sobue G, Koike H, Yabe I, Sasaki H, Watanabe O, Takashima H, Nishizawa M, Kawachi I, Kusunoki S, Mitsui Y, Kikuchi S, Nakashima I, Ikeda S, Kohara K, Kanda T, Kira JI, Hanaoka H, Kuwabara S

LANCET NEUROLOGY 15 ( 11 ) 1129 - 1137 2016.10

Research paper (scientific journal), Joint Work,  ISSN  1474-4422

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Long-term effect of sitagliptin on endothelial function in type 2 diabetes: A sub-analysis of the PROLOGUE study

Maruhashi T., Higashi Y., Kihara Y., Yamada H., Sata M., Ueda S., Odawara M., Terauchi Y., Dai K., Ohno J., Iida M., Sano H., Tomiyama H., Inoue T., Tanaka A., Murohara T., Node K., Ajioka M., Aoyama T., Babazono T., Bando Y., Daida H., Fukui J., Hamano K., Hashimoto S., Hayashi K., Hirano T., Horibe H., Ibaraki K., Iino T., Iino K., Ito H., Ishibashi Y., Ishiguro Y., Yasu T., Ishihara M., Ishiki R., Ishizu T., Ito M., Iwama Y., Izawa H., Kaku K., Kamiya H., Kan K., Kashihara N., Kimura A., Kishimoto I., Kitagawa K., Kitakaze M., Kitano T., Kizaki Y., Kohara K., Koiwaya H., Kondo T., Kosaka T., Kuriyama N., Kuroki S., Maemura K., Masuzaki H., Matsuhisa M., Miwa K., Miwa T., Yasuoka C., Miyazaki T., Mori K., Mune T., Nakadaira I., Nakamura M., Nakashima Y., Nakayama M., Nanasato M., Nitta K., Oguma Y., Ohmura H., Okubo S., Oyama J., Yamamoto H., Ri S., Sadamatsu K., Saitoh M., Sakakibara M., Sato Y., Shibata Y., Shigeta T., Shimada K., Somura F., Takei T., Tanaka T., Tanioka Y., Terasawa A., Tsujii M., Tsuruoka S., Tsutsui H., Umeda H., Urashima M., Watanabe H., Yamada T., Watarai M., Yamashina A., Yamashita K.

Cardiovascular Diabetology (Cardiovascular Diabetology)  15 ( 1 )  2016.09

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© 2016 The Author(s). Background: As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 diabetes. Methods: In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, FMD was measured in 17 patients in the sitagliptin group and 18 patients in the conventional group at the beginning and after 12 and 24 months of treatment. Results: HbA1c levels were significantly decreased after 12 and 24 months of treatment compared to baseline values in both groups (7.0 ± 0.4 vs. 6.6 ± 0.3 and 6.6 ± 0.4 % in the sitagliptin group; 7.0 ± 0.6 vs. 6.6 ± 0.7 and 6.6 ± 0.7 % in the conventional group; P < 0.05, respectively). There was no significant difference between FMD values at baseline and after 12 and 24 months in the sitagliptin group (4.3 ± 2.6 vs. 4.4 ± 2.1 and 4.4 ± 2.3 %, P = 1.0, respectively). Although FMD had a tendency to increase from 4.3 ± 2.4 % at baseline to 5.2 ± 1.9 % after 12 months and 5.1 ± 2.2 % after 24 months in the conventional group, there was no significant difference between FMD values at baseline and after 12 and 24 months (P = 0.36 and 0.33, respectively). Conclusions: Add-on sitagliptin to conventional antihyperglycemic drugs in patients with type 2 diabetes did not alter endothelial function in the conduit brachial artery measured by FMD during a 2-year study period. Sitagliptin may be used without concern for an adverse effect on endothelial function in patients with type 2 diabetes. Trial registration: University hospital Medical Information Network (UMIN) Center: ID UMIN000004490

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Rationale and design of a multicenter randomized controlled study to evaluate the preventive effect of ipragliflozin on carotid atherosclerosis: the PROTECT study

Tanaka A, Murohara T, Taguchi I, Eguchi K, Suzuki M, Kitakaze M, Sato Y, Ishizu T, Higashi Y, Yamada H, Nanasato M, Shimabukuro M, Teragawa H, Ueda S, Kodera S, Matsuhisa M, Kadokami T, Kario K, Nishio Y, Inoue T, Maemura K, Oyama J, Ohishi M, Sata M, Tomiyama H, Node K

CARDIOVASCULAR DIABETOLOGY 15   507 - 514 2016.09

Research paper (scientific journal), Joint Work,  ISSN  1475-2840

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Gender Differences in Long-Term Survival after Surgery for Non-Small Cell Lung Cancer

Yoshida, Yukihiro, Murayama, Tomonori, Sato, Yasunori, Suzuki, Yoshio, Saito, Haruhisa, Nomura, Yukihiro

THORACIC AND CARDIOVASCULAR SURGEON 64 ( 6 ) 507 - 514 2016.09

Research paper (scientific journal), Joint Work,  ISSN  0171-6425

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Nondominant small follicles are a promising source of mature oocytes in modified natural cycle in vitro fertilization and embryo transfer

Teramoto, Shokichi, Osada, Hisao, Sato, Yasunori, Shozu, Makio

FERTILITY AND STERILITY 106 ( 1 ) 113 - 118 2016.07

Research paper (scientific journal), Joint Work,  ISSN  0015-0282

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Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models

Ameku, Tomonaga, Taura, Daisuke, Sone, Masakatsu, Numata, Tomohiro, Nakamura, Masahiro, Shiota, Fumihiko, Toyoda, Taro, Matsui, Satoshi, Araoka, Toshikazu, Yasuno, Tetsuhiko, Mae, Shin-Ichi, Kobayashi, Hatasu, Kondo, Naoya, Kitaoka, Fumiyo, Amano, Naoki, Arai, Sayaka, Ichisaka, Tomoko, Matsuura, Norio, Inoue, Sumiko, Yamamoto, Takuya, Takahashi, Kazutoshi, Asaka, Isao, Yamada, Yasuhiro, Ubara, Yoshifumi, Muso, Eri, Fukatsu, Atsushi, Watanabe, Akira, Sato, Yasunori, Nakahata, Tatsutoshi, Mori, Yasuo, Koizumi, Akio, Nakao, Kazuwa, Yamanaka, Shinya, Osafune, Kenji

SCIENTIFIC REPORTS 6   507 - 514 2016.07

Research paper (scientific journal), Joint Work,  ISSN  2045-2322

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Eosinopenia as a Predictive Factor of the Short-Term Risk of Mortality and Infection after Acute Cerebral Infarction

Hori, Yusuke S., Kodera, Satoshi, Sato, Yasunori, Shiojiri, Toshiaki

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 25 ( 6 ) 1307 - 1312 2016.06

Research paper (scientific journal), Joint Work,  ISSN  1052-3057

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The Effect of Sitagliptin on Carotid Artery Atherosclerosis in Type 2 Diabetes: The PROLOGUE Randomized Controlled Trial

Oyama J, Murohara T, Kitakaze M, Ishizu T, Sato Y, Kitagawa K, Kamiya H, Ajioka M, Ishihara M, Dai K, Nanasato M, Sata M, Maemura K, Tomiyama H, Higashi Y, Kaku K, Yamada H, Matsuhisa M, Yamashita K, Bando YK, Kashihara N, Ueda S, Inoue T, Node K

PLOS MEDICINE 13 ( 6 ) 507 - 514 2016.06

Research paper (scientific journal), Joint Work,  ISSN  1549-1676

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Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study

Oyama J, Tanaka A, Sato Y, Tomiyama H, Sata M, Ishizu T, Taguchi I, Kuroyanagi T, Teragawa H, Ishizaka N, Kanzaki Y, Ohishi M, Eguchi K, Higashi Y, Yamada H, Maemura K, Ako J, Bando Y, Ueda S, Inoue T, Murohara T, Node K

CARDIOVASCULAR DIABETOLOGY 15   113 - 118 2016.06

Research paper (scientific journal), Joint Work,  ISSN  1475-2840

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Development and validation of asthma questionnaire for assessing and achieving best control in preschool-age children

Sato, Kazuki, Sato, Yasunori, Nagao, Mizuho, Shimojo, Naoki, Yoshihara, Shigemi, Adachi, Yuichi, Kameda, Makoto, Terada, Akihiko, Fujisawa, Takao

PEDIATRIC ALLERGY AND IMMUNOLOGY 27 ( 3 ) 307 - 312 2016.05

Research paper (scientific journal), Joint Work,  ISSN  0905-6157

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Relationship between the efficacy of oral antidiabetic drugs and clinical features in type 2 diabetic patients (JDDM38)

Kanatsuka A, Sato Y, Kawai K, Hirao K, Kobayashi M, Kashiwagi A

JOURNAL OF DIABETES INVESTIGATION 7 ( 3 ) 386 - 395 2016.05

Research paper (scientific journal), Joint Work,  ISSN  2040-1116

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Rationale and design of a randomized trial to test the safety and non-inferiority of canagliflozin in patients with diabetes with chronic heart failure: the CANDLE trial

Tanaka, Atsushi, Inoue, Teruo, Kitakaze, Masafumi, Oyama, Jun-ichi, Sata, Masataka, Taguchi, Isao, Shimizu, Wataru, Watada, Hirotaka, Tomiyama, Hirofumi, Ako, Junya, Sakata, Yasushi, Anzai, Toshihisa, Uematsu, Masaaki, Suzuki, Makoto, Eguchi, Kazuo, Yamashina, Akira, Saito, Yoshihiko, Sato, Yasunori, Ueda, Shinichiro, Murohara, Toyoaki, Node, Koichi

CARDIOVASCULAR DIABETOLOGY 15   307 - 312 2016.04

Research paper (scientific journal), Joint Work,  ISSN  1475-2840

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Income Related Inequality of Health Care Access in Japan: A Retrospective Cohort Study

Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

PLOS ONE 11 ( 3 ) 307 - 312 2016.03

Research paper (scientific journal), Joint Work,  ISSN  1932-6203

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Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes

Shoji M., Kobayashi K., Takemoto M., Sato Y., Yokote K.

Biomarkers (Biomarkers)  21 ( 2 ) 164 - 167 2016.02

ISSN  1354750X

　View Summary

© 2015 Taylor & Francis. Diabetic nephropathy has dramatically increased worldwide. In this study, we measured urinary podocalyxin in 240 patients with diabetes. The relationship between urinary podocalyxin and clinical parameters and the effects of dipeptidyl peptidase-4 inhibitors (DPP4i) and alpha-glucosidase inhibitor (a-GI) on urinary podocalyxin levels were examined. Urinary podocalyxin levels were significantly higher in patients with microalbuminuria than in those with normoalbuminuria. Urinary podocalyxin levels were also significantly related to albumin-to-creatinine ratio. Neither DPP4i nor α-GI ameliorated the increase in urinary podocalyxin levels. Our results indicated that urinary podocalyxin will be not only an early marker but also a treatment target for DN.

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Preoperative characteristics and surgical outcomes of acute intramural hematoma involving the ascending aorta: A propensity score-matched analysis

Matsushita, Akihito, Fukui, Toshihiro, Tabata, Minoru, Sato, Yasunori, Takanashi, Shuichiro

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 151 ( 2 ) 351 - 358 2016.02

Research paper (scientific journal), Joint Work,  ISSN  0022-5223

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Effectiveness of a cognitive behavioural therapy-based anxiety prevention programme for children: a preliminary quasi-experimental study in Japan

Urao, Yuko, Yoshinaga, Naoki, Asano, Kenichi, Ishikawa, Ryotaro, Tano, Aya, Sato, Yasunori, Shimizu, Eiji

CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH 10   307 - 312 2016.02

Research paper (scientific journal), Joint Work

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Cognitive Behavioral Therapy for Patients with Social Anxiety Disorder Who Remain Symptomatic following Antidepressant Treatment: A Randomized, Assessor-Blinded, Controlled Trial

Yoshinaga, Naoki, Matsuki, Satoshi, Niitsu, Tomihisa, Sato, Yasunori, Tanaka, Mari, Ibuki, Hanae, Takanashi, Rieko, Ohshiro, Keiko, Ohshima, Fumiyo, Asano, Kenichi, Kobori, Osamu, Yoshimura, Kensuke, Hirano, Yoshiyuki, Sawaguchi, Kyoko, Koshizaka, Masaya, Hanaoka, Hideki, Nakagawa, Akiko, Nakazato, Michiko, Iyo, Masaomi, Shimizu, Eiji

PSYCHOTHERAPY AND PSYCHOSOMATICS 85 ( 4 ) 208 - 217 2016

Research paper (scientific journal), Joint Work,  ISSN  0033-3190

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医学・薬学研究における症例数設計

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 30 ( 2 ) 190 - 197 2016

Research paper (scientific journal), Joint Work, Accepted

医学・薬学研究における生存時間データの統計解析

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 30 ( 5 ) 659 - 665 2016

Research paper (scientific journal), Joint Work, Accepted

医学・薬学研究における統計モデル解析. 日本小児アレルギー学会誌

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 30 ( 4 ) 580 - 586 2016

Research paper (scientific journal), Joint Work, Accepted

Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP: A Japanese-European multicenter prospective study

Mitsuma S, Van den Bergh P, Rajabally YA, Van Parijs V, Martin-Lamb D, Sonoo M, Inaba A, Shimizu T, Isose S, Sato Y, Komori T, Misawa S, Kuwabara S; Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group

CLINICAL NEUROPHYSIOLOGY 126 ( 9 ) 1805 - 1810 2015.09

Research paper (scientific journal), Joint Work,  ISSN  1388-2457

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Shape of the lateral edge of the first metatarsal head changes depending on the rotation and inclination of the first metatarsal: a study using digitally reconstructed radiographs

Yamaguchi, Satoshi, Sasho, Takahisa, Endo, Jun, Yamamoto, Yohei, Akagi, Ryuichiro, Sato, Yasunori, Takahashi, Kazuhisa

JOURNAL OF ORTHOPAEDIC SCIENCE 20 ( 5 ) 868 - 874 2015.09

Research paper (scientific journal), Joint Work,  ISSN  0949-2658

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Quantitative Assessment of Tendon Healing by Using MR T2 Mapping in a Rabbit Achilles Tendon Transection Model Treated with Platelet-rich Plasma

Fukawa, Taisuke, Yamaguchi, Satoshi, Watanabe, Atsuya, Sasho, Takahisa, Akagi, Ryuichiro, Muramatsu, Yuta, Akatsu, Yorikazu, Katsuragi, Joe, Endo, Jun, Osone, Fumio, Sato, Yasunori, Okubo, Toshiyuki, Takahashi, Kazuhisa

RADIOLOGY 276 ( 3 ) 748 - 755 2015.09

Research paper (scientific journal), Joint Work,  ISSN  0033-8419

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Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice

Toyohara, Takafumi, Mae, Shin-lchi, Sueta, Shin-lchi, Inoue, Tatsuyuki, Yamagishi, Yukiko, Kawamoto, Tatsuya, Kasahara, Tomoko, Hoshina, Azusa, Toyoda, Taro, Tanaka, Hiromi, Araoka, Toshikazu, Sato-Otsubo, Aiko, Takahashi, Kazutoshi, Sato, Yasunori, Yamaji, Noboru, Ogawa, Seishi, Yamanaka, Shinya, Osafune, Kenji

STEM CELLS TRANSLATIONAL MEDICINE 4 ( 9 ) 980 - 992 2015.09

Research paper (scientific journal), Joint Work,  ISSN  2157-6564

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足部X線における第一中足骨頭の形状は、中足骨の回旋と傾斜により変化する デジタル再構成シミュレーション画像を用いた検討

山口 智志, 山本 陽平, 中川 量介, 佐藤 泰憲, 佐粧 孝久, 赤木 龍一郎, 星 裕子, 佐々木 俊英, 佐藤 祐介, 高橋 和久

日本足の外科学会雑誌 ((一社)日本足の外科学会)  36 ( 2 ) S186 - S186 2015.09

ISSN  0916-7927

A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial

Shibuya, Kazumoto, Misawa, Sonoko, Kimura, Hideki, Noto, Yu-Ichi, Sato, Yasunori, Sekiguchi, Yukari, Iwai, Yuta, Mitsuma, Satsuki, Beppu, Minako, Watanabe, Keisuke, Fujimaki, Yumi, Tsuji, Yukiko, Shimizu, Toshio, Mizuno, Toshiki, Nakagawa, Masanori, Sawaguchi, Kyoko, Hanaoka, Hideki, Kuwabara, Satoshi

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION 16 ( 5-6 ) 353 - 358 2015.08

Research paper (scientific journal), Joint Work,  ISSN  2167-8421

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Predictive Power of a Body Shape Index for Development of Diabetes, Hypertension, and Dyslipidemia in Japanese Adults: A Retrospective Cohort Study

Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

PLOS ONE 10 ( 6 ) 194 - 200 2015.06

Research paper (scientific journal), Joint Work,  ISSN  1932-6203

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A multi-institutional prospective observational study of SRS for patients with multiple brain metastases (BMs)

Yamamoto, Masaaki, Serizawa, Toru, Higuchi, Yoshinori, Sato, Yasunori, Kawagishi, Jun, Yamanaka, Kazuhiro, Shuto, Takashi, Akabane, Atsuya, Jokura, Hidefumi, Yomo, Shoji, Nagano, Osamu, Aoyama, Hidefumi

JOURNAL OF CLINICAL ONCOLOGY 33 ( 15 ) 1805 - 1810 2015.05

Research paper (international conference proceedings), Joint Work,  ISSN  0732-183X

Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative

Katsuragi J., Sasho T., Yamaguchi S., Sato Y., Watanabe A., Akagi R., Muramatsu Y., Mukoyama S., Akatsu Y., Fukawa T., Endo J., Hoshi H., Yamamoto Y., Sasaki T., Takahashi K.

Osteoarthritis and Cartilage (Osteoarthritis and Cartilage)  23 ( 3 ) 383 - 390 2015.03

ISSN  10634584

　View Summary

© 2014 Osteoarthritis Research Society International. Objective: To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development. Methods: Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1at baseline and grade ≥2at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets of the patellofemoral joint (PM and PL, respectively); tibial spine (TS); and femoral intercondylar notch (IC). Knee joint osteophyte size was assessed via the 8-point marginal osteophytes item of the whole-organ magnetic resonance imaging score (WORMS). The frequencies and distributions of osteophytes were compared between groups. Results: Mild-size osteophytes (defined as score ≥2) were observed more frequently at the MFC (P=0.00278), MTP (P=0.0046), TS (P=0.0146), PM (P<0.0001), PL (P=0.0012), and IC (P<0.0001) in PROA knees than in NOA knees. Moderate-size osteophytes (defined as score ≥4) were more frequently observed in PROA knees than in NOA knees only at the IC (P<0.0001). Conclusion: Knees with osteophyte formation at the IC, even those of K/L severity grade 0/1, are at risk for the development of radiographic OA by 48 months.

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Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone

Yokoh H, Kobayashi K, Sato Y, Takemoto M, Uchida D, Kanatuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K, on behalf of the SUCCESS Study Group

JOURNAL OF DIABETES INVESTIGATION 6 ( 2 ) 182 - 191 2015.03

Research paper (scientific journal), Joint Work,  ISSN  2040-1116

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Current symptomatology in multiple sclerosis and neuromyelitis optica

Muto M., Mori M., Sato Y., Uzawa A., Masuda S., Uchida T., Kuwabara S.

European Journal of Neurology (European Journal of Neurology)  22 ( 2 ) 299 - 304 2015.02

ISSN  13515101

　View Summary

© 2014 EAN. Background and objectives: Several symptoms and signs are characteristic of multiple sclerosis (MS) such as Lhermitte's sign, Uhthoff's phenomenon and painful tonic seizure. Neuromyelitis optica (NMO) is another inflammatory disease of the central nervous system, and most of the opticospinal form of MS is thought to be NMO. This study aimed to investigate the frequencies of symptoms and signs, previously regarded as characteristic of MS, in NMO and MS patients. Methods: Consecutive Japanese NMO-plus patients [NMO (n = 30) or partial NMO (n = 18)] and MS patients (n = 128) seen at Chiba University Hospital between 2011 and 2012 were investigated for the frequencies of symptoms and signs characteristic of MS. Logistic regression analyses were used to identify factors that distinguished NMO-plus from MS. Results: Univariate analyses revealed that tonic seizures, Lhermitte's sign, persistent pain, fatigue and girdle sensation were more frequent in NMO-plus patients than in MS patients. Multivariate logistic regression analysis showed that paroxysmal itching, Uhthoff's phenomenon, Lhermitte's sign and girdle sensation were more characteristic of NMO-plus than of MS. Conclusions: Several classical MS symptoms and signs are more frequent in NMO patients than MS patients, which may be caused by the differences in the severity of inflammation, and localization and extensiveness of demyelinated lesions.

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Efficacy of Peanut and Soybean-Specific IgE Probability Curves Derived from Two Different Serologic Methods (3g and immunoCAP)

Ogura, Kiyotake, Sato, Sakura, Kutsuwada, Kazuko, Sato, Yasunori, Ebisawa, Motohiro

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 135 ( 2 ) AB248 - AB248 2015.02

Research paper (international conference proceedings), Joint Work,  ISSN  0091-6749

Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial

Katayama K, Misawa S, Sato Y, Sobue G, Yabe I, Watanabe O, Nishizawa M, Kusunoki S, Kikuchi S, Nakashima I, Ikeda S, Kohara N, Kanda T, Kira J, Hanaoka H, Kuwabara S

BMJ OPEN 5 ( 1 ) 182 - 191 2015

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Validity assessment of self-reported medication use by comparing to pharmacy insurance claims

Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

BMJ OPEN 5 ( 11 ) 307 - 312 2015

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial)

Aoyagi R, Hamada H, Sato Y, Suzuki H, Onouchi Y, Ebata R, Nagashima K, Terauchi M, Terai M, Hanaoka H, Hata A

BMJ OPEN 5 ( 12 ) 307 - 312 2015

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Prognostic Factors for Surgically Resected N2 Non-small Cell Lung Cancer

Kawasaki, Keishi, Sato, Yasunori, Suzuki, Yoshio, Saito, Haruhisa, Nomura, Yukihiro, Yoshida, Yukihiro

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 21 ( 3 ) 217 - 222 2015

Research paper (scientific journal), Joint Work,  ISSN  1341-1098

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Worse Prognosis for Stage IA Lung Cancer Patients with Smoking History and More Severe Chronic Obstructive Pulmonary Disease

Yoshida, Yukihiro, Kage, Hidenori, Murakawa, Tomohiro, Sato, Yasunori, Ota, Satoshi, Fukayama, Masashi, Nakajima, Jun

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 21 ( 3 ) 194 - 200 2015

Research paper (scientific journal), Joint Work,  ISSN  1341-1098

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Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: Retrospective cohort study

Misawa S., Sato Y., Katayama K., Hanaoka H., Sawai S., Beppu M., Nomura F., Shibuya K., Sekiguchi Y., Iwai Y., Watanabe K., Amino H., Ohwada C., Takeuchi M., Sakaida E., Nakaseko C., Kuwabara S.

BMJ Open (BMJ Open)  5 ( 11 )  2015

　View Summary

Objective: POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterised by plasma cell dyscrasia and overproduction of vascular endothelial growth factor (VEGF). VEGF is assumed to be useful in monitoring disease activity, because VEGF levels usually decrease after treatment. However, there is no study to investigate whether the extent of decrease in VEGF correlates with clinical outcome. We tested the predictive efficacy of serum VEGF levels in POEMS syndrome. Method: This was an institutional review board approved retrospective observational cohort study of 20 patients with POEMS monitored regularly for more than 12 months (median follow-up, 87 months) after treatment onset using our prospectively accumulated database of POEMS from 1999 to 2015. Patients were treated by autologous peripheral blood stem cell transplantation or thalidomide administration. Serum VEGF was measured by ELISA. Outcome measures included clinical and laboratory findings and relapsefree survival. Results: Serum VEGF levels decreased rapidly after treatment, and stabilised by 6 months post treatment. Patients with normalised serum VEGF levels (<1040 pg/mL) at 6 months showed prolonged relapsefree survival (HR=12.81, 95% CI 2.691 to 90.96; p=0.0001) and greater later clinical improvement. The rate of serum VEGF reduction over the first 6 months post treatment correlated with increased grip strength, serum albumin levels, and compound muscle action potential amplitudes at 12 months. Conclusions: Serum VEGF level at 6 months post treatment is a predicative biomarker for disease activity and prognosis in POEMS syndrome. Serum VEGF could be used as a surrogate endpoint for relapse-free survival or clinical or laboratory improvement of POEMS syndrome for clinical trials.

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臨床研究における生物統計学の基礎

佐藤泰憲, 五所正彦

日本小児アレルギー学会誌 29 ( 1 ) 79 - 85 2015

Research paper (scientific journal), Single Work, Accepted

医学・薬学データの統計解析I：推定と検定

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 29 ( 5 ) 718 - 723 2015

Research paper (scientific journal), Joint Work, Accepted

疫学研究の計画：研究デザインとデータ解析

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 29 ( 3 ) 312 - 317 2015

Research paper (scientific journal), Joint Work, Accepted

臨床試験の計画：試験デザインとデータ解析

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 29 ( 2 ) 214 - 221 2015

Research paper (scientific journal), Joint Work, Accepted

Stereotactic radiosurgery for patients with multiple brain metastases: a case-matched study comparing treatment results for patients with 2-9 versus 10 or more tumors

Yamamoto, Masaaki, Kawabe, Takuya, Sato, Yasunori, Higuchi, Yoshinori, Nariai, Tadashi, Watanabe, Shinya, Kasuya, Hidetoshi

JOURNAL OF NEUROSURGERY 121   16 - 25 2014.12

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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Validity of Prognostic Grading Indices for Brain Metastasis Patients Undergoing Repeat Radiosurgery

Yamamoto, Masaaki, Kawabe, Takuya, Higuchi, Yoshinori, Sato, Yasunori, Nariai, Tadashi, Watanabe, Shinya, Barfod, Bierta E., Kasuya, Hidetoshi

WORLD NEUROSURGERY 82 ( 6 ) 182 - 191 2014.12

Research paper (scientific journal), Joint Work,  ISSN  1878-8750

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Ultra-pure soft water improves skin barrier function in children with atopic dermatitis: A randomized, double-blind, placebo-controlled, crossover pilot study

Togawa, Yaei, Kambe, Naotomo, Shimojo, Naoki, Nakano, Taiji, Sato, Yasunori, Mochizuki, Hiroyuki, Tanaka, Akane, Matsuda, Hiroshi, Matsue, Hiroyuki

JOURNAL OF DERMATOLOGICAL SCIENCE 76 ( 3 ) 269 - 271 2014.12

Research paper (scientific journal), Joint Work,  ISSN  0923-1811

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Effect of covariate omission in Weibull accelerated failure time model: A caution

Gosho, Masahiko, Maruo, Kazushi, Sato, Yasunori

BIOMETRICAL JOURNAL 56 ( 6 ) 991 - 1000 2014.11

Research paper (scientific journal), Joint Work,  ISSN  0323-3847

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Efficacy of Continuous Venovenous Hemodiafiltration on Survival of Cardiac Arrest in Humans

Shinozaki, Koichiro, Sato, Yasunori, Becker, Lance B., Oda, Shigeto, Hirasawa, Hiroyuki

CIRCULATION 130   28 - 38 2014.11

Research paper (international conference proceedings), Joint Work,  ISSN  0009-7322

Long-term outcomes of artificial chordal replacement with tourniquet technique in mitral valve repair: A single-center experience of 700 cases

Tabata, Minoru, Kasegawa, Hitoshi, Fukui, Toshihiro, Shimizu, Atsushi, Sato, Yasunori, Takanashi, Shuichiro

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 148 ( 5 ) 2033 - + 2014.11

Research paper (scientific journal), Joint Work,  ISSN  0022-5223

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Predictive factors for acetabular labral lesions in osteoarthritis of the hip with radial magnetic resonance imaging - A cross-sectional study

Takazawa, Makoto, Nakamura, Junichi, Abe, Isao, Ohtori, Seiji, Watanabe, Atsuya, Sato, Yasunori, Sasho, Takahisa, Orita, Sumihisa, Suzuki, Masahiko, Motoori, Ken, Masuda, Yoshitada, Takahashi, Kazuhisa, Kishida, Shunji

MODERN RHEUMATOLOGY 24 ( 6 ) 974 - 979 2014.11

Research paper (scientific journal), Joint Work,  ISSN  1439-7595

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Stereotactic radiosurgery for brain metastases: a case-matched study comparing treatment results for patients 80 years of age or older versus patients 65-79 years of age

Watanabe, Shinya, Yamamoto, Masaaki, Sato, Yasunori, Kawabe, Takuya, Higuchi, Yoshinori, Kasuya, Hidetoshi, Yamamoto, Tetsuya, Matsumura, Akira, Barfod, Bierta E.

JOURNAL OF NEUROSURGERY 121 ( 5 ) 1148 - 1157 2014.11

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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Genetic and non-genetic factors responsible for antiplatelet effects of clopidogrel in Japanese patients undergoing coronary stent implantation: An algorithm to predict on-clopidogrel platelet reactivity

Miura, Go, Ariyoshi, Noritaka, Sato, Yasunori, Yamaguchi, Hiroki, Iwata, Yo, Fujimoto, Yoshihide, Kobayashi, Yoshio, Ishii, Itsuko

THROMBOSIS RESEARCH 134 ( 4 ) 877 - 883 2014.10

Research paper (scientific journal), Joint Work,  ISSN  0049-3848

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Effects of Metformin on Endometrial Cancer Cell Growth in Vivo: A Preoperative Prospective Trial

Mitsuhashi, Akira, Kiyokawa, Takako, Sato, Yasunori, Shozu, Makio

CANCER 120 ( 19 ) 2986 - 2995 2014.10

Research paper (scientific journal), Joint Work,  ISSN  0008-543X

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The incidence of pediatric invasive Haemophilus influenzae and pneumococcal disease in Chiba prefecture, Japan before and after the introduction of conjugate vaccines

Ishiwada, Naruhiko, Hishiki, Haruka, Nagasawa, Koo, Naito, Sachiko, Sato, Yasunori, Chang, Bin, Sasaki, Yuko, Kimura, Kouji, Ohnishi, Makoto, Shibayama, Keigo

VACCINE 32 ( 42 ) 5425 - 5431 2014.09

Research paper (scientific journal), Joint Work,  ISSN  0264-410X

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Evaluation of insulin regimens as an effective option for glycemic control in patients with type 2 diabetes: A propensity score-matched cohort study across Japan (JDDM31)

Kanatsuka A, Sato Y, Kawai K, Hirao K, Kobayashi M, Kashiwagi A, Japan Diabetes Clinical Data Management Study Group

JOURNAL OF DIABETES INVESTIGATION 5 ( 5 ) 539 - 547 2014.09

Research paper (scientific journal), Joint Work,  ISSN  2040-1116

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Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with α-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on sulfonylurea alone (SUCCESS-2): A multicenter, randomized, open-label, non-inferiority trial

Kobayashi K., Yokoh H., Sato Y., Takemoto M., Uchida D., Kanatsuka A., Kuribayashi N., Terano T., Hashimoto N., Sakurai K., Hanaoka H., Ishikawa K., Onishi S., Yokote K., An T., Tokuyama H., Bujo H., Kawamura H., Shibata T., Tatsuno I., Ishibashi T., Nakamura S., Mikami K., Yamamoto K., Yamada K., Hirota Y., Tadokoro N., Tokuyama T., Ishibashi R., Nakamura S., Tashiro J., Yamamoto K., Ban T., Sano R., Ito H., Tanaka T., Nishimura S., Saito K., Nishimura M., Fuse M., Mimura M., Suzuki S., Tachibana K., Yamada M., Ishikawa T., Nakamura M., Oji T., Fujimoto M.

Diabetes, Obesity and Metabolism (Diabetes, Obesity and Metabolism)  16 ( 8 ) 761 - 765 2014.08

ISSN  14628902

　View Summary

We assessed the efficacy and safety of sitagliptin compared with α-glucosidase inhibitor (αGI) in 120 of Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on stable ≤2mg/day glimepiride alone [mean hemoglobin A1c (HbA1c) 7.7%] by the randomized, active-controlled, non-inferiority trial. Patients were randomly assigned to receive additional sitagliptin or αGI for 24weeks. The primary endpoint was change in HbA1c from baseline to week 12. After 12weeks, sitagliptin reduced HbA1c by -0.44% (p<0.001) relative to αGI. At 24weeks, the reduction was almost identical between the groups (-0.091%, p=0.47). Gastrointestinal disorders were more common with αGI than with sitagliptin, but only minor hypoglycaemia occurred in both groups at similar frequency. These data suggested that sitagliptin was not inferior to αGI for reduction of HbA1c in Japanese T2DM patients receiving glimepiride alone, and well tolerated with minimum risk of gastrointestinal symptoms and hypoglycaemia. © 2014 John Wiley & Sons Ltd.

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軟骨下骨の不整は、48ヵ月後の変形性膝関節症発症の予測因子である OAIのデータから

葛城 穣, 佐粧 孝久, 佐藤 泰憲, 山口 智志, 赤木 龍一郎, 村松 佑太, 向山 俊輔, 赤津 頼一, 府川 泰輔, 遠藤 純, 高橋 和久

JOSKAS ((一社)日本関節鏡・膝・スポーツ整形外科学会)  39 ( 4 ) 150 - 150 2014.07

ISSN  1884-8842

Rationale and design of a study to evaluate the effects of sitagliptin on atherosclerosis in patients with diabetes mellitus: PROLOGUE study

Oyama, Jun-ichi, Ishizu, Tomoko, Sato, Yasunori, Kodama, Kazuhisa, Bando, Yasuko K., Murohara, Toyoaki, Node, Koichi

INTERNATIONAL JOURNAL OF CARDIOLOGY 174 ( 2 ) 383 - 384 2014.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0167-5273

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Stereotactic radiosurgery for patients with brain metastases Reply

Yamamoto, Masaaki, Serizawa, Toru, Shuto, Takashi, Akabane, Atsuya, Higuchi, Yoshinori, Kawagishi, Jun, Yamanaka, Kazuhiro, Sato, Yasunori, Jokura, Hidefumi

LANCET ONCOLOGY 15 ( 7 ) E248 - E248 2014.06

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1470-2045

Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study

Yamamoto, Masaaki, Serizawa, Toru, Shuto, Takashi, Akabane, Atsuya, Higuchi, Yoshinori, Kawagishi, Jun, Yamanaka, Kazuhiro, Sato, Yasunori, Jokura, Hidefumi, Yomo, Shoji, Nagano, Osamu, Kenai, Hiroyuki, Moriki, Akihito, Suzuki, Satoshi, Kida, Yoshihisa, Iwai, Yoshiyasu, Hayashi, Motohiro, Onishi, Hiroaki, Gondo, Masazumi, Sato, Mitsuya, Akimitsu, Tomohide, Kubo, Kenji, Kikuchi, Yasuhiro, Shibasaki, Toru, Goto, Tomoaki, Takanashi, Masami, Mori, Yoshimasa, Takakura, Kintomo, Saeki, Naokatsu, Kunieda, Etsuo, Aoyama, Hidefumi, Momoshima, Suketaka, Tsuchiya, Kazuhiro

LANCET ONCOLOGY 15 ( 4 ) 387 - 395 2014.04

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1470-2045

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Utility Of Probability Curves Using 3gAllergy For Diagnosis Of Wheat Allergy

Sato, Sakura, Ogura, Kiyotake, Sato, Yasunori, Ebisawa, Motohiro

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 133 ( 2 ) AB114 - AB114 2014.02

Research paper (international conference proceedings), Joint Work, Accepted,  ISSN  0091-6749

Robust covariance estimator for small-sample adjustment in the generalized estimating equations: A simulation study

Gosho, M, Sato, Y, Takeuchi, H

Science Journal of Applied Mathematics and Statistics 2   20 - 25 2014.02

Accepted

Genetic factors associated with gemcitabine pharmacokinetics, disposition, and toxicity

Knights, Jonathan, Sato, Yasunori, Kaniwa, Nahoko, Saito, Yoshiro, Ueno, Hideki, Ramanathan, Murali

PHARMACOGENETICS AND GENOMICS 24 ( 1 ) 15 - 25 2014.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1744-6872

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Outcomes of contemporary emergency open surgery for type A acute aortic dissection in elderly patients

Matsushita, Akihito, Tabata, Minoru, Fukui, Toshihiro, Sato, Yasunori, Matsuyama, Shigefumi, Shimokawa, Tomoki, Takanashi, Shuichiro

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 147 ( 1 ) 290 - 294 2014.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-5223

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Simple interrupted suturing increases valve performance after aortic valve replacement with a small supra-annular bioprosthesis

Tabata, Minoru, Shibayama, Kentaro, Watanabe, Hiroyuki, Sato, Yasunori, Fukui, Toshihiro, Takanashi, Shuichiro

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 147 ( 1 ) 321 - 325 2014.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0022-5223

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Expression of CD203c on basophils as a marker of immunoglobulin E-mediated L-asparaginase allergy

Hino, Moeko, Shimojo, Naoki, Ochiai, Hidemasa, Inoue, Yuzaburo, Ando, Kumiko, Chikaraishi, Koji, Ota, Setsuo, Okimoto, Yuri, Sunami, Shosuke, Nakamura, Ryosuke, Teshima, Reiko, Sato, Yasunori, Kohno, Yoichi

LEUKEMIA & LYMPHOMA 55 ( 1 ) 92 - 96 2014.01

Research paper (scientific journal), Joint Work, Accepted,  ISSN  1042-8194

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Validation of 7th TNM staging system for lung cancer, based on surgical outcomes

Yoshida, Y., Murayama, T., Sato, Y., Suzuki, Y., Saito, H. and Tanaka, N.

Asian Cardiovasc Thorac Ann 21 ( 6 ) 693 - 9 2013.12

Research paper (scientific journal), Joint Work,  ISSN  0218-4923

　View Summary

BACKGROUND: Validation of the clinical classification for lung cancer of the 7th edition of the TNM staging system among surgical cases has not been reported previously. METHODS: Data of 489 males and 246 females, with a mean age of 67.6 years, who underwent surgical resection for non-small-cell lung cancer were analyzed retrospectively. RESULTS: The 5-year survival rate of these patients was 72.2% for clinical stage IA (n = 365), 58.4% for IB (n = 158), 51.2% for IIA (n = 77), 49.1% for IIB (n = 42), 36.8% for IIIA (n = 86), 80% for IIIB (n = 5) and 50% for IV (n = 2). The 5-year survival rate of patients was 100% for pathological stage 0 (n = 2), 86.1% for IA (n = 216), 73.8% for IB (n = 173), 46.1% for IIA (n = 97), 47.2% for IIB (n = 69), 33.3% for IIIA (n = 155), 33.3% for IIIB (n = 3) and 30.9% for IV (n = 20). Prognostic factors included female sex and 70 years of age or younger, as well as adenocarcinoma histology. CONCLUSIONS: Deterioration in patient survival was indicated with the exception of stages IIIB and IV, each of which included only a small number of patients. Our study validated the current TNM staging system in surgical cases with regard to both clinical and pathological classifications.

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An efficient and robust method for analyzing population pharmacokinetic data in genome-wide pharmacogenomic studies: a generalized estimating equation approach

Nagashima, K., Sato, Y., Noma, H. and Hamada, C.

Stat Med 32 ( 27 ) 4838 - 58 2013.11

Research paper (scientific journal), Joint Work,  ISSN  0277-6715

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Powerful array-based single-nucleotide polymorphism-typing platforms have recently heralded a new era in which genome-wide studies are conducted with increasing frequency. A genetic polymorphism associated with population pharmacokinetics (PK) is typically analyzed using nonlinear mixed-effect models (NLMM). Applying NLMM to large-scale data, such as those generated by genome-wide studies, raises several issues related to the assumption of random effects as follows: (i) computation time: it takes a long time to compute the marginal likelihood; (ii) convergence of iterative calculation: an adaptive Gauss-Hermite quadrature is generally used to estimate NLMM; however, iterative calculations may not converge in complex models; and (iii) random-effects misspecification leads to slightly inflated type-I error rates. As an alternative effective approach to resolving these issues, in this article, we propose a generalized estimating equation (GEE) approach for analyzing population PK data. In general, GEE analysis does not account for interindividual variability in PK parameters; therefore, the usual GEE estimators cannot be interpreted straightforwardly, and their validities have not been justified. Here, we propose valid inference methods for using GEE even under conditions of interindividual variability and provide theoretical justifications of the proposed GEE estimators for population PK data. In numerical evaluations by simulations, the proposed GEE approach exhibited high computational speed and stability relative to the NLMM approach. Furthermore, the NLMM analysis was sensitive to the misspecification of the random-effects distribution, and the proposed GEE inference is valid for any distributional form. We provided an illustration by using data from a genome-wide pharmacogenomic study of an anticancer drug.

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Split hand syndrome in amyotrophic lateral sclerosis: different excitability changes in the thenar and hypothenar motor axons

Shibuya, K., Misawa, S., Nasu, S., Sekiguchi, Y., Mitsuma, S., Beppu, M., Ohmori, S., Iwai, Y., Ito, S., Kanai, K., Sato, Y. and Kuwabara, S.

J Neurol Neurosurg Psychiatry 84 ( 9 ) 969 - 72 2013.09

Joint Work,  ISSN  0022-3050

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BACKGROUND: In amyotrophic lateral sclerosis (ALS), muscle wasting preferentially affects the abductor pollicis brevis (APB) and first dorsal interosseous over the abductor digit minimi (ADM), and this is termed 'split hand'. Previous axonal excitability studies have suggested increased nodal persistent sodium current and reduced potassium current in motor axons in ALS, but the extent of excitability changes in APB and ADM axons in ALS has never been compared. OBJECTIVE: To elucidate the peripheral axonal pathophysiology of split hand. METHODS: In both APB and ADM motor axons of 21 patients with ALS and 17 age-matched normal controls, threshold tracking was used to measure excitability indices such as strength-duration time constant (SDTC; a measure of persistent sodium current) and threshold electrotonus. RESULTS: In normal controls, SDTC was significantly longer for APB than ADM axons, suggesting that axonal excitability is physiologically higher in APB axons. Compared with normal controls, patients with ALS had longer SDTC and greater threshold changes in depolarising threshold electrotonus in both APB and ADM axons. Furthermore, the difference in extent of SDTC prolongation between normal subjects and patients with ALS was greater in APB than ADM axons. CONCLUSIONS: APB axons have physiologically higher excitability than ADM axons, and, in ALS, the hyperexcitability is more prominent in APB axons. Although cortical mechanisms would also be involved, more prominent hyperexcitability of APB axons may contribute to development of split hand, and the altered axonal properties are possibly associated with motor neuronal death in ALS.

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Retinol palmitate prevents ischemia-induced cell changes in hippocampal neurons through the Notch1 signaling pathway in mice

Shimada, Jun-Ichiro, Taniguchi, Junko, Mori, Masahiro, Sato, Yasunori, Takuwa, Hiroyuki, Ito, Hiroshi, Kuwabara, Satoshi

EXPERIMENTAL NEUROLOGY 247   182 - 187 2013.09

Research paper (scientific journal), Joint Work,  ISSN  0014-4886

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Effects of a Sitagliptin Safety Alert on Prescription Behaviour for Oral Antihyperglycaemic Drugs: A Propensity Score-Matched Cohort Study of Prescription Receipt Data in Japan

Sato, Daisaku, Sato, Yasunori, Masuda, Sachiko, Kimura, Hiromichi

DRUG SAFETY 36 ( 8 ) 605 - 615 2013.08

Research paper (scientific journal), Joint Work,  ISSN  0114-5916

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大腿骨顆間部に形成される骨棘は、48ヵ月後の変形性膝関節症発症の予測因子である OAIのデータから

葛城 穣, 佐粧 孝久, 山口 智志, 赤木 龍一郎, 村松 佑太, 向山 俊輔, 赤津 頼一, 府川 泰輔, 遠藤 純, 佐藤 泰憲, 高橋 和久

日本整形外科学会雑誌 ((公社)日本整形外科学会)  87 ( 8 ) S1412 - S1412 2013.08

ISSN  0021-5325

Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin Compared With alpha-Glucosidase Inhibitor in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Metformin or Pioglitazone Alone (SUCCESS1)

SATO Yasunori

DIABETES 62   A306 - A306 2013.07

Research paper (international conference proceedings),  ISSN  0012-1797

Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin Compared With Alpha-Glucosidase Inhibitor in Japanese Patients With Type 2 Diabetes Treated With Sulfonylurea Alone (SUCCESS2): A Multicenter, Randomized, Open-Label, Clinical Trial

69. Kobayashi K, Yokoh H, Sato Y, Takemoto M, Uchida D, Kanatsuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K

DIABETES 62   A301 - A301 2013.07

Research paper (scientific journal), Joint Work,  ISSN  0012-1797

Gadoxetic acid-enhanced MRI compared with CT during angiography in the diagnosis of hepatocellular carcinoma

Ooka, Yoshihiko, Kanai, Fumihiko, Okabe, Shinichiro, Ueda, Takuya, Shimofusa, Ryota, Ogasawara, Sadahisa, Chiba, Tetsuhiro, Sato, Yasunori, Yoshikawa, Masaharu, Yokosuka, Osamu

MAGNETIC RESONANCE IMAGING 31 ( 5 ) 748 - 754 2013.06

Research paper (scientific journal), Joint Work,  ISSN  0730-725X

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A case-matched study of stereotactic radiosurgery for patients with multiple brain metastases: comparing treatment results for 1-4 vs >= 5 tumors Clinical article

Yamamoto, Masaaki, Kawabe, Takuya, Sato, Yasunori, Higuchi, Yoshinori, Nariai, Tadashi, Barfod, Bierta E., Kasuya, Hidetoshi, Urakawa, Yoichi

JOURNAL OF NEUROSURGERY 118 ( 6 ) 1258 - 1268 2013.06

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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Effects of Pitavastatin in Japanese Patients With Chronic Heart Failure - The Pitavastatin Heart Failure Study (PEARL Study)

56. Takano H, Mizuma H, Kuwabara Y, Sato Y, Shindo S, Fujimatsu D, Inoue T, Node K, Komuro I.

CIRCULATION JOURNAL 77 ( 4 ) 917 - 925 2013.04

Research paper (scientific journal),  ISSN  1346-9843

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Seasonality of multiple sclerosis and neuromyelitis optica exacerbations in Japan

Muto, Mayumi, Mori, Masahiro, Sato, Yasunori, Uzawa, Akiyuki, Masuda, Saeko, Kuwabara, Satoshi

MULTIPLE SCLEROSIS JOURNAL 19 ( 3 ) 378 - 379 2013.03

Research paper (scientific journal), Joint Work,  ISSN  1352-4585

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Validity of two recently-proposed prognostic grading indices for lung, gastro-intestinal, breast and renal cell cancer patients with radiosurgically-treated brain metastases

Yamamoto, M., Serizawa, T., Sato, Y., Kawabe, T., Higuchi, Y., Nagano, O., Barfod, B. E., Ono, J., Kasuya, H. and Urakawa, Y.

J Neurooncol 111 ( 3 ) 327 - 35 2013.02

Research paper (scientific journal), Joint Work,  ISSN  0167-594

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We tested the validity of two prognostic indices for stereotactic radiosurgically (SRS)-treated patients with brain metastases (BMs) from five major original cancer categories. The two indices are Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) and our Modified Recursive Partitioning Analysis (RPA). Forty-six hundred and eight BM patients underwent gamma knife SRS during the 1998-2011 period. Primary cancer categories were non-small cell lung cancer (NSCLC, 2827 patients), small cell lung cancer (SCLC, 460), gastro-intestinal cancer (GIC, 582), breast cancer (BC, 547) and renal cell cancer (RCC, 192). There were statistically significant survival differences among patients stratified into four groups based on the DS-GPA systems (p < 0.001) in all five original cancer categories. In the NSCLC category, there were statistically significant mean survival time (MST) differences (p < 0.001) among the four groups without overlapping of 95 % confidence intervals (CIs) between any two pairs of groups with the DS-GPA system. However, among the SCLC, GIC, BC and RCC categories, MST differences between some pairs of groups failed to reach statistical significance with this system. There were, however, statistically significant MST differences (p < 0.001) among the three groups without overlapping of 95 % CIs between any two pairs of groups with the Modified RPA system in all five categories. The DS-GPA system is applicable to our set of patients with NSCLC only. However, the Modified RPA system was shown to be applicable to patients with five primary cancer categories. This index should be considered when designing future clinical trials involving BM patients.

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Delayed Complications in Patients Surviving at Least 3 Years After Stereotactic Radiosurgery for Brain Metastases

Yamamoto, Masaaki, Kawabe, Takuya, Higuchi, Yoshinori, Sato, Yasunori, Nariai, Tadashi, Barfod, Bierta E., Kasuya, Hidetoshi, Urakawa, Yoichi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 85 ( 1 ) 53 - 60 2013.01

Research paper (scientific journal), Joint Work,  ISSN  0360-3016

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Cytokine Biomarker Candidates in Breast Milk Associated with the Development of Atopic Dermatitis in 6-Month-Old Infants

Ochiai, Shingo, Shimojo, Naoki, Morita, Yoshinori, Tomiita, Minako, Arima, Takayasu, Inoue, Yuzaburo, Nakaya, Mayuko, Uehara, Naoki, Sato, Yasunori, Mori, Chisato, Suzuki, Yoichi, Kohno, Yoichi

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 160 ( 4 ) 401 - 408 2013

Research paper (scientific journal), Joint Work,  ISSN  1018-2438

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Validity of Recently-Proposed Prognostic Grading Indices for Brain Metastasis Patients Undergoing Repeat Radiosurgery

Yamamoto, Masaaki, Kawabe, Takuya, Higuchi, Yoshinori, Sato, Yasunori, Barfd, Bierta E., Kasuya, Hidetoshi, Urakawa, Yoichi

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 91   302 - 302 2013

Research paper (scientific journal), Joint Work,  ISSN  1011-6125

Validity Test of the Modified Recursive Partitioning Analysis for Brain Metastases Cases from Breast Cancer Treated Radiosurgically

Nagano, Osamu, Serizawa, Toru, Sato, Yasunori, Higuchi, Yoshinori, Ono, Junichi, Saeki, Naokatsu

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 91   64 - 64 2013

Research paper (scientific journal), Joint Work,  ISSN  1011-6125

Home telemonitoring study for Japanese patients with heart failure (HOMES-HF): protocol for a multicentre randomised controlled trial

Kotooka N, Asaka M, Sato Y, Kinugasa Y, Nochioka K, Mizuno A, Nagatomo D, Mine D, Yamada Y, Eguchi K, Hanaoka H, Inomata T, Fukumoto Y, Yamamoto K, Tsutsui H, Masuyama T, Kitakaze M, Inoue T, Shimokawa H, Momomura S, Seino Y, Node K; HOMES-HF study investigators.

BMJ OPEN 3 ( 6 ) 499 - 503 2013

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Strategy for treating selective serotonin reuptake inhibitor-resistant social anxiety disorder in the clinical setting: a randomised controlled trial protocol of cognitive behavioural therapy in combination with conventional treatment

Yoshinaga, Naoki, Niitsu, Tomihisa, Hanaoka, Hideki, Sato, Yasunori, Ohshima, Fumiyo, Matsuki, Satoshi, Kobori, Osamu, Nakazato, Michiko, Nakagawa, Akiko, Iyo, Masaomi, Shimizu, Eiji

BMJ OPEN 3 ( 2 ) 378 - 379 2013

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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全身血管の動脈硬化から腎障害にともなう組織学的変化は予測可能か

268. 古荘泰佑, 小寺聡, 神田順二, 藤井隼彦, 吉田裕, 鈴木良夫, 佐藤泰憲

日本血管内治療学会誌 14 ( 1 ) 25 - 31 2013

Research paper (scientific journal), Joint Work, Accepted

個別化医療のための研究デザイン : Enrichment Designを中心に(特別セッション「医薬品開発における最近の話題」,セッション4A)

佐藤 泰憲, 長島 健悟

日本計算機統計学会大会論文集 (日本計算機統計学会)  27   89 - 92 2013

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Validity of Three Recently Proposed Prognostic Grading Indexes for Breast Cancer Patients With Radiosurgically Treated Brain Metastases

Yamamoto, Masaaki, Kawabe, Takuya, Higuchi, Yoshinori, Sato, Yasunori, Barfod, Bierta E., Kasuya, Hidetoshi, Urakawa, Yoichi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 84 ( 5 ) 1110 - 1115 2012.12

Research paper (scientific journal),  ISSN  0360-3016

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Gamma Knife surgery for patients with brainstem metastases Clinical article

Kawabe, Takuya, Yamamoto, Masaaki, Sato, Yasunori, Barfod, Bierta E., Urakawa, Yoichi, Kasuya, Hidetoshi, Mineura, Katsuyoshi

JOURNAL OF NEUROSURGERY 117   23 - 30 2012.12

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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Impact of the sitagliptin alert on prescription of oral antihyperglycemic drugs in Japan

Sato, Daisaku, Sato, Yasunori, Masuda, Sachiko, Kimura, Hiromichi

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY 34 ( 6 ) 917 - 924 2012.12

Research paper (scientific journal), Joint Work,  ISSN  2210-7703

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Gamma Knife surgery for patients with brainstem metastases.

Kawabe T., Yamamoto M., Sato Y., Barfod B., Urakawa Y., Kasuya H., Mineura K.

Journal of neurosurgery (Journal of neurosurgery)  117 Suppl   23 - 30 2012.12

　View Summary

Because brainstem metastases are not deemed resectable, stereotactic radiosurgery (SRS) is the only treatment modality expected to achieve a radical cure. The authors describe their treatment results, focusing particularly on how long patients can survive without neurological deterioration following SRS for brainstem metastases. This was an institutional review board-approved, retrospective cohort study in which the authors pulled from their database information on 2553 consecutive patients with brain metastases who underwent Gamma Knife surgery (GKS) at the Mito GammaHouse between July 1998 and July 2011. Among the 2553 patients, excluding cases in which there was meningeal dissemination, 200 cases of brainstem metastases (78 women and 122 men with a mean age of 64 years [range 36-86 years]) were identified and analyzed. The most common primary site was the lung (137 patients) followed by the gastrointestinal tract (24 patients), breast (17 patients), kidney (12 patients), and others (10 patients). Among the 200 patients, 15 patients (7.5%) harbored at least 2 tumors in the brainstem: 11 patients had 2 tumors, 2 patients had 3 tumors, and 1 patient each had 4 or 5 tumors. Therefore, a total of 222 tumors were irradiated. These 222 tumors were located in the pons (121 lesions), the midbrain (65 lesions), and the medulla oblongata (36 lesions). The mean and median tumor volumes were 1.3 and 0.2 cm(3) (range 0.005-10.7 cm(3)), and the median peripheral radiation dose was 18.0 Gy (range 12.0-25.0 Gy). The overall median survival time (MST) was 6.0 months. Distribution of MSTs across Recursive Partitioning Analysis (RPA) classes showed that the MSTs were 9.4 months in Class I (20 patients), 6.0 months in Class II (171 patients), and 1.9 months in Class III (9 patients). Better Karnofsky Performance Scale score, single metastasis, and well-controlled primary tumor were significant predictive factors for longer survival. The neurological and qualitative survival rates were 90.8% and 89.2%, respectively, at 24 months post-GKS. Better KPS score and smaller tumor volume tended to be associated with prolonged qualitative survival. Follow-up imaging studies were available for 129 patients (64.5%). The tumor control rate was 81.8% at 24 months post-GKS. Smaller tumor volume tended to contribute to tumor control. The present results indicate that GKS is effective in the treatment of brainstem metastases, particularly from the viewpoint of maintaining a good neurological condition in the patient.

Self-Referral in Radiation Oncology: Has Caveat Emptor Replaced Primum Non Nocere? Reply

Yamamoto, Masaaki, Sato, Yasunori, Serizawa, Toru, Kawabe, Takuya, Higuchi, Yoshinori, Nagano, Osamu, Barfod, Bierta E., Ono, Junichi, Kasuya, Hidetoshi, Urakawa, Yoichi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 84 ( 4 ) 876 - 877 2012.11

Research paper (scientific journal), Joint Work,  ISSN  0360-3016

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Tumor necrosis factor-308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients

Watanabe, Eizo, Zehnbauer, Barbara A., Oda, Shigeto, Sato, Yasunori, Hirasawa, Hiroyuki, Buchman, Timothy G.

CYTOKINE 60 ( 1 ) 249 - 256 2012.10

Research paper (scientific journal), Joint Work,  ISSN  1043-4666

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Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias

Sakai, Shio, Nakaseko, Chiaki, Takeuchi, Masahiro, Ohwada, Chikako, Shimizu, Naomi, Tsukamoto, Shokichi, Kawaguchi, Takeharu, Jiang, Meizi, Sato, Yasunori, Ebinuma, Hiroyuki, Yokote, Koutaro, Iwama, Atsushi, Fukamachi, Isamu, Schneider, Wolfgang Johann, Saito, Yasushi, Bujo, Hideaki

CLINICA CHIMICA ACTA 413 ( 19-20 ) 1542 - 1548 2012.10

Research paper (scientific journal), Joint Work,  ISSN  0009-8981

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Subclassification of Recursive Partitioning Analysis Class II Patients With Brain Metastases Treated Radiosurgically

Yamamoto, Masaaki, Sato, Yasunori, Serizawa, Toru, Kawabe, Takuya, Higuchi, Yoshinori, Nagano, Osamu, Barfod, Bierta E., Ono, Junichi, Kasuya, Hidetoshi, Urakawa, Yoichi

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 83 ( 5 ) 1399 - 1405 2012.08

Research paper (scientific journal), Joint Work,  ISSN  0360-3016

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Motor axonal excitability properties are strong predictors for survival in amyotrophic lateral sclerosis

Kanai, Kazuaki, Shibuya, Kazumoto, Sato, Yasunori, Misawa, Sonoko, Nasu, Saiko, Sekiguchi, Yukari, Mitsuma, Satsuki, Isose, Sagiri, Fujimaki, Yumi, Ohmori, Shigeki, Koga, Shunsuke, Kuwabara, Satoshi

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 83 ( 7 ) 734 - 738 2012.07

Research paper (scientific journal), Joint Work,  ISSN  0022-3050

Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age: An initial study

Kazama, Toshiki, Kuroki, Yoshifumi, Kikuchi, Mari, Sato, Yasunori, Nagashima, Takeshi, Miyazawa, Yukimasa, Sakakibara, Masahiro, Kaneoya, Katsuhiko, Makimoto, Yumi, Hashimoto, Hideyuki, Motoori, Ken, Takano, Hideyuki

JOURNAL OF MAGNETIC RESONANCE IMAGING 36 ( 1 ) 139 - 144 2012.07

Research paper (scientific journal), Joint Work,  ISSN  1053-1807

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CSF interleukin-6 level predicts recovery from neuromyelitis optica relapse

Uzawa, Akiyuki, Mori, Masahiro, Sato, Yasunori, Masuda, Saeko, Kuwabara, Satoshi

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 83 ( 3 ) 339 - 340 2012.03

Research paper (scientific journal), Joint Work,  ISSN  0022-3050

Transplantation of alveolar type II cells stimulates lung regeneration during compensatory lung growth in adult rats

Wada, Hironobu, Yoshida, Shigetoshi, Suzuki, Hidemi, Sakairi, Yuichi, Mizobuchi, Teruaki, Komura, Daisuke, Sato, Yasunori, Yokoi, Sana, Yoshino, Ichiro

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 143 ( 3 ) 711 - + 2012.03

Research paper (scientific journal), Joint Work,  ISSN  0022-5223

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Antiganglioside antibodies are associated with axonal Guillain-Barre syndrome: A Japanese-Italian collaborative study

Sekiguchi, Yukari, Uncini, Antonino, Yuki, Nobuhiro, Misawa, Sonoko, Notturno, Francesca, Nasu, Saiko, Kanai, Kazuaki, Noto, Yu-ichi, Fujimaki, Yumi, Shibuya, Kazumoto, Ohmori, Shigeki, Sato, Yasunori, Kuwabara, Satoshi

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 83 ( 1 ) 23 - 28 2012.01

Research paper (scientific journal), Joint Work,  ISSN  0022-3050

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Analysis of 2000 cases treated with gamma knife surgery: validating eligibility criteria for a prospective multi-institutional study of stereotactic radiosurgery alone for treatment of patients with 1-10 brain metastases (JLGK0901) in Japan

Serizawa, T., Higuchi, Y., Nagano, O., Sato, Y., Yamamoto, M., Ono, J., Saeki, N., Miyakawa, A. and Hirai, T.

J Radiosurg SBRT 2 ( 1 ) 19 - 27 2012

Joint Work,  ISSN  2156-4639

　View Summary

Objective: The Japan Leksell Gamma Knife (JLGK) Society has conducted a prospective multi-institute study (JLGK0901, UNIN000001812) for selected patients in order to prove the effectiveness of stereotactic radiosurgery (SRS) alone using the gamma knife (GK) for 1-10 brain lesions. Herein, we verify the validity of 5 major patient selection criteria for the JLGK0901 trial. Materials and Methods: Between 1998 and 2010, 2246 consecutive cases with 10352 brain metastases treated with GK were analyzed to determine the validity of the following 5 major JLGK0901 criteria; 1) 1-10 brain lesions, 2) less than 10 cm(3) volume of the largest tumor, 3) no more than 15 cm(3) total tumor volume, 4) no cerebrospinal fluid (CSF) dissemination, 5) Karnofsky performance status (KPS) score >/=70. Results: For cases with >10 brain metastases, salvage treatments for new lesions were needed more frequently. The tumor control rate for lesions larger than 10 cm(3) was significantly lower than that of tumors <10 cm(3). Overall, neurological and qualitative survivals (OS, NS, QS) of cases with >15 cm(3) total tumor volume or positive magnetic resonance imaging findings of CSF were significantly poorer. Outcomes in cases with KPS <70 were significantly poorer in terms of OS. Conclusion: Our retrospective results of 2246 GK-treated cases verified the validity of the 5 major JLGK0901 criteria. The inclusion criteria for the JLGK0901 study are appearently good indications for SRS.

Markedly reduced axonal potassium channel expression in human sporadic amyotrophic lateral sclerosis: An immunohistochemical study

Shibuya, Kazumoto, Misawa, Sonoko, Arai, Kimihito, Nakata, Miho, Kanai, Kazuaki, Yoshiyama, Yasumasa, Ito, Kimiko, Isose, Sagiri, Noto, Yu-ichi, Nasu, Saiko, Sekiguchi, Yukari, Fujirnaki, Yumi, Ohmori, Shigeki, Kitamura, Hiroshi, Sato, Yasunori, Kuwabara, Satoshi

EXPERIMENTAL NEUROLOGY 232 ( 2 ) 149 - 153 2011.12

Research paper (scientific journal), Joint Work,  ISSN  0014-4886

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Urinary dysfunction in early and untreated Parkinson's disease

Uchiyama, Tomoyuki, Sakakibara, Ryuji, Yamamoto, Tatsuya, Ito, Takashi, Yamaguchi, Chiharu, Awa, Yusuke, Yanagisawa, Mitsuru, Higuchi, Yoshinori, Sato, Yasunori, Ichikawa, Tomohiko, Yamanishi, Tomonori, Hattori, Takamichi, Kuwabara, Satoshi

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 82 ( 12 ) 1382 - 1386 2011.12

Research paper (scientific journal), Joint Work,  ISSN  0022-3050

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Activity-dependent changes in impulse conduction of single human motor axons: A stimulated single fiber electromyography study

Noto, Yu-ichi, Misawa, Sonoko, Kanai, Kazuaki, Sato, Yasunori, Shibuya, Kazumoto, Isose, Sagiri, Nasu, Saiko, Sekiguchi, Yukari, Fujimaki, Yumi, Ohmori, Shigeki, Nakagawa, Masanori, Kuwabara, Satoshi

CLINICAL NEUROPHYSIOLOGY 122 ( 12 ) 2512 - 2517 2011.12

Research paper (scientific journal), Joint Work,  ISSN  1388-2457

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Inter-observer and intra-observer reliabilities of the Japanese Ministry of Health, Labor and Welfare type classification system for osteonecrosis of the femoral head

Nakamura, J., Kishida, S., Harada, Y., Iida, S., Oinuma, K., Yamamoto, S., Nakajima, T., Takazawa, M., Shigemura, T., Ohtori, S., Sato, Y. and Takahashi, K.

Mod Rheumatol 21 ( 5 ) 488 - 94 2011.10

Joint Work,  ISSN  1439-7595

　View Summary

The aim of this study was to clarify the reproducibility of the Japanese Ministry of Health, Labor and Welfare (JMHLW) type classification for osteonecrosis of the femoral head. We performed inter-observer and intra-observer trials using 40 sets of magnetic resonance imagings, 20 of which were produced by a 0.5 Tesla (T) superconductive unit and the other 20 produced by a 1.5 T unit, in patients with non-collapsed and asymptomatic osteonecrosis of the femoral head (JMHLW stage 1 or 2). The JMHLW type classification (A, B, C1, or C2) was determined from T1-weighted coronal images at the center of the femoral head. Six orthopedic surgeons independently assessed all 40 images twice, with an interval of 4-5 weeks between sessions. Regarding inter-observer reliability, the percent agreement was 85% and weighted kappa was 0.709 for 0.5 T, versus a percent agreement of 82% and weighted kappa of 0.724 for 1.5 T. Regarding intra-observer reliability, the percent agreement was 82% and weighted kappa was 0.780 for 0.5 T versus a percent agreement of 80% and weighted kappa of 0.800 for 1.5 T. Inter-observer and intra-observer reliabilities did not differ significantly between the 0.5 and 1.5 T units. The JMHLW type classification provided high inter-observer and intra-observer reliabilities.

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A New Classification of Recursive Partitioning Analysis (RPA) Class II Patients with Radiosurgically Treated Brain Metastases

Yamamoto, Masaaki, Sato, Yasunori, Serizawa, Toru, Kawabe, Takuya, Higuchi, Yoshinori, Nagano, Osamu, Barfod, Bierta E.

JOURNAL OF NEUROSURGERY 115 ( 2 ) A448 - A448 2011.08

Research paper (international conference proceedings), Joint Work,  ISSN  0022-3085

Prescription Trends for Oral Antihyperglycemic Drugs (OHDs) in Japan - The Influence of Drug Interaction Alerts Concerning Hypoglycemia in Using Dipeptidyl Peptidase-4 (DPP-4) Inhibitor

Sato, Daisaku, Masuda, Sachiko, Sato, Yasunori, Kimura, Hiromichi

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY 20   S102 - S102 2011.08

Research paper (international conference proceedings), Joint Work,  ISSN  1053-8569

Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in the treatment of malignant pleural mesothelioma

Kitamura, Atsushi, Matsushita, Kazuyuki, Takiguchi, Yuichi, Shimada, Hideaki, Tada, Yuji, Yamanaka, Makako, Hiroshima, Kenzo, Tagawa, Masatoshi, Tomonaga, Takeshi, Matsubara, Hisahiro, Inoue, Makoto, Hasegawa, Mamoru, Sato, Yasunori, Levens, David, Tatsumi, Koichiro, Nomura, Fumio

CANCER SCIENCE 102 ( 7 ) 1366 - 1373 2011.07

Research paper (scientific journal), Joint Work,  ISSN  1347-9032

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Blood ammonia and lactate levels on hospital arrival as a predictive biomarker in patients with out-of-hospital cardiac arrest

Shinozaki, Koichiro, Oda, Shigeto, Sadahiro, Tomohito, Nakamura, Masataka, Hirayama, Yo, Watanabe, Eizo, Tateishi, Yoshihisa, Nakanishi, Kazuya, Kitamura, Nobuya, Sato, Yasunori, Hirasawa, Hiroyuki

RESUSCITATION 82 ( 4 ) 404 - 409 2011.04

Research paper (scientific journal), Joint Work,  ISSN  0300-9572

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Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value

Noto, Yu-Ichi, Shibuya, Kazumoto, Sato, Yasunori, Kanai, Kazuaki, Misawa, Sonoko, Sawai, Setsu, Mori, Masahiro, Uchiyama, Tomoyuki, Isose, Sagiri, Nasu, Saiko, Sekiguchi, Yukari, Fujimaki, Yumi, Kasai, Takashi, Tokuda, Takahiko, Nakagawa, Masanori, Kuwabara, Satoshi

AMYOTROPHIC LATERAL SCLEROSIS 12 ( 2 ) 140 - 143 2011.03

Research paper (scientific journal), Joint Work,  ISSN  1748-2968

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New Uncoated Vascular Prosthesis Reduces Mediastinal Tube Drainage After Thoracic Aortic Surgery

Tabata, Minoru, Shimokawa, Tomoki, Fukui, Toshihiro, Manabe, Susumu, Sato, Yasunori, Takanashi, Shuichiro

ANNALS OF THORACIC SURGERY 91 ( 3 ) 899 - 902 2011.03

Research paper (scientific journal), Joint Work,  ISSN  0003-4975

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Genome-Wide Association Study on Overall Survival of Advanced Non-small Cell Lung Cancer Patients Treated with Carboplatin and Paclitaxel

Sato, Yasunori, Yamamoto, Noboru, Kunitoh, Hideo, Ohe, Yuichiro, Minami, Hironobu, Laird, Nan M., Katori, Noriko, Saito, Yoshiro, Ohnami, Sumiko, Sakamoto, Hiromi, Sawada, Jun-ichi, Saijo, Nagahiro, Yoshida, Teruhiko, Tamura, Tomohide

JOURNAL OF THORACIC ONCOLOGY 6 ( 1 ) 132 - 138 2011.01

Research paper (scientific journal), Joint Work,  ISSN  1556-0864

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A Modified Maximum Contrast Method for Unequal Sample Sizes in Pharmacogenomic Studies

Nagashima, Kengo, Sato, Yasunori, Hamada, Chikuma

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 10 ( 1 ) 149 - 153 2011

Research paper (scientific journal), Joint Work,  ISSN  1544-6115

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REV1 genetic polymorphisms and breast cancer risk in Thai Women

Sangrajrang S., Sato Y., Sakamoto H., Ohnami S., Khuhaprema T., Yoshida T.

Genes and Environment (Genes and Environment)  33 ( 4 ) 167 - 172 2011

ISSN  18807046

　View Summary

Genomic DNA is exposed to a constant insult from sources that are both endogenous and exogenous to the cell. REV1 protein, a eukaryotic member of Y family of DNA polymerases, is involved in the tolerance to such DNA damages by providing a translesion DNA synthesis. Here, we examined possible association between REV1 polymorphisms and breast cancer risk in Thai women. Five single nucleotide polymorphisms (SNPs) REV1 (rs3792152, rs3087395, rs3792137, rs959929, rs3087386) were genotyped. The study population consists of 570 patients with histopathologically confirmed breast cancer and 497 controls. Association of genotypes with breast cancer risk was evaluated using multivariate logistic regression to estimate odds ratios (OR) and their 95z confidence intervals (95zCI). Our results revealed that the heterozygote carrier of REV1 SNP (rs3087395) was associated with breast cancer risk with OR=1.59 (95 zCI: 1.11-2.29). In addition, an increased risk was observed for homozygotes at the REV1 SNP (rs 959929) with the OR=1.52 (95zCI: 1.01-2.29). A stratified analysis suggested that the association between the REV1 SNPs and breast cancer is different by the menopausal status. The present results suggest thatREV1 polymorphisms are likely to play a modifying role in the individual susceptibility to breast cancer among Thai women. © The Japanese Environmental Mutagen Society.

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Cytokine and chemokine profiles in neuromyelitis optica: significance of interleukin-6

Uzawa, Akiyuki, Mori, Masahiro, Arai, Kimihito, Sato, Yasunori, Hayakawa, Sei, Masuda, Saeko, Taniguchi, Junko, Kuwabara, Satoshi

MULTIPLE SCLEROSIS 16 ( 12 ) 1443 - 1452 2010.12

Research paper (scientific journal), Joint Work,  ISSN  1352-4585

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Gamma Knife surgery as sole treatment for multiple brain metastases: 2-center retrospective review of 1508 cases meeting the inclusion criteria of the JLGK0901 multi-institutional prospective study

Serizawa, Toru, Yamamoto, Masaaki, Sato, Yasunori, Higuchi, Yoshinori, Nagano, Osamu, Kawabe, Takuya, Matsuda, Shinji, Ono, Junichi, Saeki, Naokatsu, Hatano, Manabu, Hirai, Tatsuo

JOURNAL OF NEUROSURGERY 113   48 - 52 2010.12

Research paper (scientific journal), Joint Work,  ISSN  0022-3085

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A set of genes associated with the interferon-gamma response of lung cancer patients undergoing alpha-galactosylceramide-pulsed dendritic cell therapy

Okita, Kohsuke, Motohashi, Shinichiro, Shinnakasu, Ryo, Nagato, Kaoru, Yamasaki, Kazuki, Sato, Yasunori, Kitamura, Hiroshi, Hijikata, Atsushi, Yamashita, Masakatsu, Shimizu, Kanako, Fujii, Shin-ichiro, Ohara, Osamu, Taniguchi, Masaru, Sakaida, Isao, Nakayama, Toshinori

CANCER SCIENCE 101 ( 11 ) 2333 - 2340 2010.11

Research paper (scientific journal), Joint Work,  ISSN  1347-9032

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Clinical research design and statistical analysis for personalized medicine

Sato Y., Nagashima K., Hamada C.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  41 ( 6 ) 291 - 300 2010.11

ISSN  03881601

　View Summary

Interindividual variation in drug response among patients is well known and poses a serious problem in medicine. The variation could be due to multiple factors including those of the host (e. g., age, genetic and environmental factors) and disease (pathophysiological phenotypes). The complex interplay of these factors may influence pharmacodynamic responses such as adverse effects and efficacy, as well as pharmacokinetic manifestations. However, at present, few biomarkers can predict responders and non-responders, and those who might experience adverse reactions for the same medication and dose. In order to realize personalized medicine, rigorous development of biomarkers is required to identify new biomarkers that may change clinical practice. In this review, we first introduce how biomarkers may be used as targets and the difference between prognostic and predictive markers. Next, we focus on confirmatory clinical trial designs for biomarker development and introduce their application in actual studies. Finally, we introduce exploratory statistical screening techniques for detecting biomarkers in phase I and pharmacokinetics studies.

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Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women

Sangrajrang, Suleeporn, Sato, Yasunori, Sakamoto, Hiromi, Ohnami, Sumiko, Khuhaprema, Thiravud, Yoshida, Teruhiko

BREAST CANCER RESEARCH AND TREATMENT 123 ( 3 ) 885 - 893 2010.10

Research paper (scientific journal), Joint Work,  ISSN  0167-6806

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Application of Akaike information criterion to evaluate warfarin dosing algorithm

Harada, Takumi, Ariyoshi, Noritaka, Shimura, Hitoshi, Sato, Yasunori, Yokoyama, Iichiro, Takahashi, Kaori, Yamagata, Shin-ichi, Imamaki, Mizuho, Kobayashi, Yoshio, Ishii, Itsuko, Miyazaki, Masaru, Kitada, Mitsukazu

THROMBOSIS RESEARCH 126 ( 3 ) 183 - 190 2010.09

Research paper (scientific journal), Joint Work,  ISSN  0049-3848

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Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers

Andoh, Masataka, Sato, Yasunori, Sakamoto, Hiromi, Yoshida, Teruhiko, Ohtaki, Megu

JOURNAL OF HUMAN GENETICS 55 ( 7 ) 436 - 440 2010.07

Research paper (scientific journal), Joint Work,  ISSN  1434-5161

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Biostatistic Tools in Pharmacogenomics - Advances, Challenges, Potential

Sato, Yasunori, Laird, Nan M., Yoshida, Teruhiko

CURRENT PHARMACEUTICAL DESIGN 16 ( 20 ) 2232 - 2240 2010.07

Research paper (scientific journal), Joint Work,  ISSN  1381-6128

Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese

Ariyoshi, Noritaka, Iga, Yukako, Hirata, Koji, Sato, Yasunori, Miura, Go, Ishii, Itsuko, Nagamori, Seiji, Kitada, Mitsukazu

DRUG METABOLISM AND PHARMACOKINETICS 25 ( 3 ) 298 - 306 2010

Research paper (scientific journal), Joint Work,  ISSN  1347-4367

Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies

14. Isose S, Kuwabara S, Kokubun N, Sato Y, Mori M, Shibuya K, Sekiguchi, Y, Nasu A, Fujimaki Y, Noto Y, Sawai S, Hirata K, Misawa S and The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 14 ( 3 ) 151 - 158 2009.09

Research paper (scientific journal), Joint Work,  ISSN  1085-9489

The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: Multivariate analyses

Fujimaki, Yumi, Kuwabara, Satoshi, Sato, Yasunori, Isose, Sagiri, Shibuya, Kazumoto, Sekiguchi, Yukari, Nasu, Saiko, Noto, Yuichi, Taniguchi, Junko, Misawa, Sonoko

CLINICAL NEUROPHYSIOLOGY 120 ( 9 ) 1683 - 1686 2009.09

Research paper (scientific journal), Joint Work,  ISSN  1388-2457

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Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women

Sangrajrang, Suleeporn, Sato, Yasunori, Sakamoto, Hiromi, Ohnami, Sumiko, Laird, Nan M., Khuhaprema, Thiravud, Brennan, Paul, Boffetta, Paulo, Yoshida, Teruhiko

INTERNATIONAL JOURNAL OF CANCER 125 ( 4 ) 837 - 843 2009.08

Research paper (scientific journal), Joint Work,  ISSN  0020-7136

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Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia

Moriya, Junji, Minamino, Tohru, Tateno, Kaoru, Shimizu, Naomi, Kuwabara, Yoichi, Sato, Yasunori, Saito, Yasushi, Komuro, Issei

CIRCULATION-CARDIOVASCULAR INTERVENTIONS 2 ( 3 ) 245 - U157 2009.06

Research paper (scientific journal), Joint Work,  ISSN  1941-7640

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A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies

Sato Y., Laird N., Nagashima A., Kato R., Hamano T., Yafune A., Kaniwa N., Saito Y., Sugiyama E., Kim S., Furuse J., Ishii H., Ueno H., Okusaka T., Saijo N., Sawada J., Yoshida T.

Pharmacogenomics Journal (Pharmacogenomics Journal)  9 ( 2 ) 137 - 146 2009.04

ISSN  1470269X

　View Summary

Biomedical researchers usually test the null hypothesis that there is no difference of the population mean of pharmacokinetics (PK) parameters between genotypes by the Kruskal-Wallis test. Although a monotone increasing pattern with a number of alleles is expected for PK-related genes, the Kruskal-Wallis test does not consider a monotonic response pattern. For detecting such patterns in clinical and toxicological trials, a maximum contrast method has been proposed. We show how that method can be used with pharmacogenomics data to a develop test of association. Further, using simulation studies, we compare the power of the modified maximum contrast method to those of the maximum contrast method and the Kruskal-Wallis test. On the basis of the results of those studies, we suggest rules of thumb for which statistics to use in a given situation. An application of all three methods to an actual genome-wide pharmacogenomics study illustrates the practical relevance of our discussion.

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Report of trainee of the foreign clinical pharmacology training progiam no 4

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  40 ( 2 ) 75 - 78 2009.03

ISSN  03881601

Report of trainee of the foreign clinical pharmacology training program no 3

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  40 ( 2 ) 67 - 69 2009.03

ISSN  03881601

Statistical Screening Method for Genetic Factors Influencing Susceptibility to Common Diseases in a Two-Stage Genome-Wide Association Study

Sato, Yasunori, Laird, Nan, Suganami, Hideki, Hamada, Chikuma, Niki, Naoto, Yoshimura, Isao, Yoshida, Teruhiko

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 8 ( 1 ) 151 - 158 2009

Research paper (scientific journal), Joint Work,  ISSN  1544-6115

His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk

Ohnami, Shumpei, Sato, Yasunori, Yoshimura, Kimio, Ohnami, Sumiko, Sakamoto, Hiromi, Aoki, Kazunori, Ueno, Hideki, Ikeda, Masafumi, Morizane, Chigusa, Shimada, Kazuaki, Sakamoto, Yoshihiro, Esaki, Minoru, Saito, Ikuo, Hirose, Hiroshi, Saito, Daizo, Sugimura, Haruhiko, Kosuge, Tomoo, Okusaka, Takuji, Yoshida, Teruhiko

GASTROENTEROLOGY 135 ( 2 ) 477 - 488 2008.08

Research paper (scientific journal), Joint Work,  ISSN  0016-5085

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Report of Trainee of the Forein Clinical Pharmacology Training Program: No. 2

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  39 ( 4 ) 123 - 125 2008.07

ISSN  03881601

Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Sakamoto H, Yoshimura K, Saeki N, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S.

NATURE GENETICS 40 ( 6 ) 730 - 740 2008.06

Research paper (scientific journal), Joint Work,  ISSN  1061-4036

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Marked differences in differentiation propensity among human embryonic stem cell lines

Osafune, Kenji, Caron, Leslie, Borowiak, Malgorzata, Martinez, Rita J., Fitz-Gerald, Claire S., Sato, Yasunori, Cowan, Chad A., Chien, Kenneth R., Melton, Douglas A.

NATURE BIOTECHNOLOGY 26 ( 3 ) 313 - 315 2008.03

Research paper (scientific journal), Joint Work,  ISSN  1087-0156

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Report of Trainee of the Foreign Clinical Pharmacology Traininng Program: No. 1

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  39 ( 2 ) 81 - 83 2008.03

ISSN  03881601

A new test statistic based on shrunken sample variance for identifying differentially expressed genes in small microarray experiments

Hirakawa, A., Sato, Y., Hamada, C. and Yoshimura, I.

Bioinform Biol Insights 2   145 - 56 2008.02

Joint Work,  ISSN  1177-9322

　View Summary

Choosing an appropriate statistic and precisely evaluating the false discovery rate (FDR) are both essential for devising an effective method for identifying differentially expressed genes in microarray data. The t-type score proposed by Pan et al. (2003) succeeded in suppressing false positives by controlling the underestimation of variance but left the overestimation uncontrolled. For controlling the overestimation, we devised a new test statistic (variance stabilized t-type score) by placing shrunken sample variances of the James-Stein type in the denominator of the t-type score. Since the relative superiority of the mean and median FDRs was unclear in the widely adopted Significance Analysis of Microarrays (SAM), we conducted simulation studies to examine the performance of the variance stabilized t-type score and the characteristics of the two FDRs. The variance stabilized t-type score was generally better than or at least as good as the t-type score, irrespective of the sample size and proportion of differentially expressed genes. In terms of accuracy, the median FDR was superior to the mean FDR when the proportion of differentially expressed genes was large. The variance stabilized t-type score with the median FDR was applied to actual colorectal cancer data and yielded a reasonable result.

Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan

Nakayama, Robert, Sato, Yasunori, Masutani, Mitsuko, Ogino, Hideki, Nakatani, Fumihiko, Chuman, Hirokazu, Beppu, Yasuo, Morioka, Hideo, Yabe, Hiroo, Hirose, Hiroshi, Sugimura, Haruhiko, Sakamoto, Hiromi, Ohta, Tsutomu, Toyama, Yoshiaki, Yoshida, Teruhiko, Kawai, Akira

CANCER SCIENCE 99 ( 2 ) 333 - 339 2008.02

Research paper (scientific journal), Joint Work,  ISSN  1347-9032

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Estimating the false discovery rate using mixed normal distribution for identifying differentially expressed genes in microarray data analysis

Hirakawa, A., Sato, Y., Sozu, T., Hamada, C. and Yoshimura, I.

Cancer Inform 3   140 - 8 2008.01

Joint Work,  ISSN  1176-9351

　View Summary

The recent development of DNA microarray technology allows us to measure simultaneously the expression levels of thousands of genes and to identify truly correlated genes with anticancer drug response (differentially expressed genes) from many candidate genes. Significance Analysis of Microarray (SAM) is often used to estimate the false discovery rate (FDR), which is an index for optimizing the identifiability of differentially expressed genes, while the accuracy of the estimated FDR by SAM is not necessarily confirmed. We propose a new method for estimating the FDR assuming a mixed normal distribution on the test statistic and examine the performance of the proposed method and SAM using simulated data. The simulation results indicate that the accuracy of the estimated FDR by the proposed method and SAM, varied depending on the experimental conditions. We applied both methods to actual data comprised of expression levels of 12,625 genes of 10 responders and 14 non-responders to docetaxel for breast cancer. The proposed method identified 280 differentially expressed genes correlated with docetaxel response using a cut-off value for achieving FDR <0.01 to prevent false-positive genes, although 92 genes were previously thought to be correlated with docetaxel response ones.

A new formula for predicting liver metastasis in patients with colorectal cancer: Immunohistochemical analysis of a large series of 439 surgically resected cases

Ochiai, Hiroki, Nakanishi, Yukihiro, Fukasawa, Yuri, Sato, Yasunori, Yoshimura, Kimio, Moriya, Yoshihiro, Kanai, Yae, Watanabe, Masahiko, Hasegawa, Hirotoshi, Kitagawa, Yuko, Kitajima, Masaki, Hirohashi, Setsuo

ONCOLOGY 75 ( 1-2 ) 32 - 41 2008

Research paper (scientific journal), Joint Work,  ISSN  0030-2414

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Association of SNPs in ABCC1 gene with overall survival in stage IV pancreatic adenocarcinoma patients treated with gemcitabine monotherapy

10. Ueno, H., Sato, Y., Okusaka, T., Furuse, J., Ishii, H., Sekine, A., Nakamura, Y., Kaniwa, N., Sawada, J., Saijo, N

J Clin Oncol   2008

Research paper (international conference proceedings), Joint Work, Accepted

Genetic polymorphisms correlate with overall survival (OS) in advanced non-small cell lung cancer (NSCLC) treated with carboplatin (CBDCA) and paclitaxel (PTX)

9. Yamamoto, N., Sato, Y., Tamura, T., Kunitoh, H., Ohe, Y., Katori, N., Sawada, J., Sekine, A., Nakamura, Y., Saijo, N

J Clin Oncol   2008

Research paper (international conference proceedings), Joint Work, Accepted

Modified multifactor dimensionality reduction method for detecting gene -gene interactions for an unbalanced sample-size

Sato, Y., Hirose M, Ando H, Suganami H, Hamada C, Yoshimura I, Yoshida T.

ISCB27  2007

Accepted

The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium

Sato, Yasunori, Suganami, Hideki, Hamada, Chikuma, Yoshimura, Isao, Sakamoto, Hiromi, Yoshida, Teruhiko, Yoshimura, Kimio

JOURNAL OF HUMAN GENETICS 51 ( 9 ) 772 - 780 2006.09

Research paper (scientific journal), Joint Work,  ISSN  1434-5161

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The confidence interval of allelic odds ratios under the Hardy-Weinberg disequilibrium

Sato, Y., Suganami H, Hamada C, Yoshimura I, Sakamoto H, Yoshida T, Yoshimura K

XXIII International Biometric Conference  2006

Research paper (international conference proceedings), Accepted

Statistical consideration of the identifications for disease-associated SNPs in Whole-genome association study

3. Sato, Y., Suganami, H., Hamada, C., Niki, N., Yoshimura, I., Yoshida, T

26th Annual conference of international society for clinical biostatistics  2005

Research paper (international conference proceedings), Accepted

Multiple imputation method for SNP typing data in linkage disequilibrium mapping of polygenic traits

2. Sato, Y., Ando, H., Suganami, H., Hamada, C., Yoshimura, I., Yoshida, T. and Yoshimura K

Joint statistical meeting 2005  2005

Research paper (international conference proceedings), Accepted

Designing a multistage, SNP-based, genome screen for common diseases

Sato, Y., Suganami, H., Hamada, C., Yoshimura, I., Yoshida, T. and Yoshimura, K.

J Hum Genet 49 ( 12 ) 669 - 76 2004

Research paper (scientific journal), Joint Work,  ISSN  1434-5161

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A genome-wide linkage equilibrium mapping is an emerging strategy to identify risk-modifying genes for common diseases, despite unsettled controversies upon many aspects, including its premises, designs, marker choices and cost benefits. One large-scale attempt in Japan aims to identify disease-associated single nucleotide polymorphisms (SNPs) for five diseases among the Japanese population: Alzheimer's disease, gastric cancer, diabetes, hypertension and asthma. Following an initial screening of c.a. 100,000 SNPs on 940 subjects (five diseases x 188 patients) to select about 2,000 SNPs, we compared which subsequent screening design is more appropriate, and an additional one or two screens to further narrow down any disease-associated SNPs within a fixed total volume of 15,040,000 typings (2,000 SNPs x five diseases x 1,504 subjects, comprising 752 cases and 752 controls). We employed a Monte Carlo simulation to evaluate the probability of identifying truly disease-associated SNPs. The results suggest the single additional stage design (i.e., total two-stage design including the initial screening of 100,000 SNPs) was more practicable for the simple reason that the gain in probability is considered insufficient relative to an associated increase in study complexity in the three-stage design.

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Two Step Sampling Design for SNP Screening Scheme in the Millennium Genome Project of Japan

1. Sato, Y., Suganami, H., Hamada, C., Yoshimura, I., Yoshida, T. and Yoshimura K

IBC 2004 XXIInd International Biometric Conference in parallel with ASC 2004 Australian Statistical Conference  2004

Research paper (international conference proceedings), Joint Work, Accepted