Papers - Sato, Yasunori

Impact of coronavirus disease 2019 on the number of newly diagnosed cancer patients and examinations and surgeries performed for cancer in Japan: a nationwide study.

Takeshi Terashima, Hiroshi Konishi, Yasunori Sato, Muneki Igarashi, Takafumi Yanagibashi, Ryo Konno, Hideyuki Saya, Yuichiro Doki, Tadao Kakizoe

BMC cancer (BMC Cancer)  22 ( 1 ) 1303 - 1303 2022.12

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BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has rapidly and dramatically influenced healthcare across Japan. However, the influence of the COVID-19 pandemic on the number of newly diagnosed cancer, surgical treatment, and diagnostic examination for cancer types have not been completely investigated all over Japan. This study aimed to analyze the number of cases before and during the COVID-19 pandemic. METHODS: This retrospective study was a survey that asked to provide the number of cases diagnosed with gastric, colorectal, lung, breast, and cervical cancer between January 2019 and December 2020. The survey was sent to tertiary healthcare hospitals, including national cancer institutions, university hospitals, and general hospitals, all over Japan. Data obtained from 105 of 486 surveyed hospitals were evaluated, and the number of cases in each quarter in 2020 was compared with that in the equivalent quarter in 2019. RESULTS: In the second quarter (Q2), significant reductions were observed in the median number of newly diagnosed cases from 2019 to 2020: gastric cancer, 26.7% (43 vs. 32, p <  0.001); colorectal cancer, 17.9% (52 vs. 40, p <  0.001); lung cancer, 12.3% (53.5 vs. 47, p <  0.001); and breast cancer, 13.1% (43 vs. 35.5, p <  0.001). A significant reduction of 11.4% (9 vs. 8, p = 0.03) was observed in the third quarter (Q3) for cervical cancer. In Q2, the number of cases decreased by 30.9% (25 vs. 15, p <  0.001) for stage I gastric cancer, by 27.3% (12 vs. 9, p <  0.001) for stage I colorectal cancer, and by 17.6% (13 vs. 10, p <  0.001) for stage II breast cancer. The magnitude of reduction was significant for the localized stages of gastric, colorectal, and breast cancer according to diagnostic examinations in Q2 and surgical and endoscopic treatment in Q3 rather than that for lung or cervical cancer. CONCLUSIONS: COVID-19 has prolonged collateral effects on cancer care, including examination, diagnosis, and surgery, with significant effects on gastric cancer, followed by colorectal, lung, breast, and cervical cancer in Japan.

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A predictive scoring system for small diaphragmatic defects in infants with congenital diaphragmatic hernia.

Keita Terui, Kouji Nagata, Masaya Yamoto, Masahiro Hayakawa, Hiroomi Okuyama, Shoichiro Amari, Akiko Yokoi, Taizo Furukawa, Kouji Masumoto, Tadaharu Okazaki, Noboru Inamura, Katsuaki Toyoshima, Yuhki Koike, Manabu Okawada, Yasunori Sato, Noriaki Usui

Pediatric surgery international (Pediatric Surgery International)  39 ( 1 ) 4 - 4 2022.11

ISSN  0179-0358

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PURPOSE: To develop a predictive score for small diaphragmatic defects in infants with congenital diaphragmatic hernia (CDH) for determining thoracoscopic surgery indication. METHODS: The Japanese CDH Study Group cohort was randomly divided into derivation (n = 397) and validation (n = 396) datasets. Using logistic regression, a prediction model and weighted scoring system for small diaphragmatic defects were created from derivation dataset and validated with validation dataset. RESULTS: Six weighted variables were selected: no hydramnios, 1 point; 1 min Apgar score of 5-10, 1 point; apex type of the lung (left lung is detected radiographically in apex area), 1 point; oxygenation index < 8, 1 point; abdominal nasogastric tube (tip of the nasogastric tube is detected radiographically in the abdominal area), 2 points; no right-to-left flow of ductus arteriosus, 1 point. In validation dataset, rates of small diaphragmatic defects for Possible (0-3 points), Probable (4-5 points), and Definite (6-7 points) groups were 36%, 81%, and 94%, respectively (p < 0.001). Additionally, sensitivity, specificity, positive predictive value, and C statistics were 0.78, 0.79, 0.88, 0.76, and 0.45, 0.94, 0.94, 0.70 for Probable and Definite groups, respectively. CONCLUSION: Our scoring system effectively predicted small diaphragmatic defects in infants with CDH.

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Impact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study.

Nakagawara K, Chubachi S, Namkoong H, Tanaka H, Lee H, Azekawa S, Otake S, Fukushima T, Morita A, Watase M, Sakurai K, Kusumoto T, Asakura T, Masaki K, Kamata H, Ishii M, Hasegawa N, Harada N, Ueda T, Ueda S, Ishiguro T, Arimura K, Saito F, Yoshiyama T, Nakano Y, Mutoh Y, Suzuki Y, Edahiro R, Murakami K, Sato Y, Okada Y, Koike R, Kitagawa Y, Tokunaga K, Kimura A, Imoto S, Miyano S, Ogawa S, Kanai T, Fukunaga K

Respiratory research (Respiratory Research)  23 ( 1 ) 315 2022.11

ISSN  1465-9921

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Background: Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients. Methods: This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1: no respiratory symptoms, Group 2: only upper respiratory symptoms, Group 3: only lower respiratory symptoms, and Group 4: both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death. Results: Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.11–0.39), while patients in Group 3 had the worst outcomes (OR: 3.27, 95% CI: 2.43–4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course. Conclusions: Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.

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Standards for assessing and reporting adverse events.

Takashi Kawakami, Shun Kohsaka, Yasunori Sato, Keiichi Fukuda, Hiromi Matsubara

The Lancet. Respiratory medicine  2022.11

ISSN  2213-2600

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Adverse effects of long-term drain placement and the importance of direct aspiration: A retrospective cohort study.

Jun Okui, Hideaki Obara, Shunsuke Uno, Yasunori Sato, Gaku Shimane, Masashi Takeuchi, Hirofumi Kawakubo, Minoru Kitago, Koji Okabayashi, Yuko Kitagawa

The Journal of hospital infection  2022.11

ISSN  0195-6701

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BACKGROUND: Long-term placement of prophylactic drains can result in retrograde infections. AIM: We aimed to investigate the association between the timing of drain removal and clinical outcomes. METHODS: This retrospective, single-center cohort study evaluated 110 patients who underwent elective gastrointestinal or hepatopancreatobiliary surgery and developed subsequent organ/space surgical site infection (SSI) between 2016 and 2020. We evaluated the difference between the culture-positive species of prophylactic drains and direct aspiration, whether the prophylactic drains functioned effectively at the time of SSI diagnosis, and whether the empirical antibiotics administered before drainage were able to treat all the detected bacteria. Finally, clinical outcomes were compared between early (i.e. cases wherein the prophylactic drain had already been removed or replaced at the time of SSI diagnosis) and late (removal after diagnosis) drain removal. FINDINGS: The prophylactic drains functioned effectively in only 27 (25%) patients at the time of SSI diagnosis. Due to the results of direct aspiration cultures, 43% of patients required antibiotic escalation. The median time to drain removal or first replacement was seven postoperative days. The early removal group included 43 patients (39%). Compared with early removal, late removal resulted in a higher frequency of vancomycin use (7.0% versus 22.4%; P = 0.037). CONCLUSIONS: Prolonged prophylactic drain placement is associated with complicated infections requiring vancomycin, therefore, the drains should be removed as soon as possible. Additionally, obtaining the cultures of direct aspiration should be actively considered, as escalation of antimicrobial therapy is often performed based on culture results.

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肺癌脳転移に対する定位放射線治療の最近の傾向　単施設における20年余2456例の経験から

山本 昌昭, 佐藤 泰憲

肺癌 ((NPO)日本肺癌学会)  62 ( 6 ) 621 - 621 2022.11

ISSN  0386-9628

認知症家族介護者の心理的負担に対する集団複合的介入プログラムの効果研究

田村 法子, 色本 涼, 長島 健悟, 佐藤 泰憲, 中川 敦夫, 三村 將, 藤澤 大介

老年精神医学雑誌 ((株)ワールドプランニング)  33 ( 増刊II ) 352 - 353 2022.11

ISSN  0915-6305

School-based cognitive behavioural intervention programme for addressing anxiety in 10- to 11-year-olds using short classroom activities in Japan: a quasi-experimental study.

Urao Y, Yoshida M, Sato Y, Shimizu E

BMC psychiatry 22 ( 1 ) 658 2022.10

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Assessing anti-SARS-CoV-2 cellular immunity in 571 vaccinees by using an interferon-γ release assay.

Wakui M, Uwamino Y, Yatabe Y, Nakagawa T, Sakai A, Kurafuji T, Shibata A, Tomita Y, Noguchi M, Tanabe A, Arai T, Ohno A, Yokota H, Uno S, Yamasawa W, Sato Y, Ikeda M, Yoshimura A, Hasegawa N, Saya H, Murata M

European journal of immunology  2022.10

ISSN  0014-2980

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認知症家族介護者の心理的負担に対する集団複合的介入プログラムの効果研究

田村 法子, 色本 涼, 長島 健悟, 佐藤 泰憲, 中川 敦夫, 三村 將, 藤澤 大介

Dementia Japan ((一社)日本認知症学会)  36 ( 4 ) 800 - 800 2022.10

ISSN  1342-646X

抗MOG抗体関連疾患を対象とした全国疫学調査(第一報)

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 桑原 聡, 中島 一郎

神経免疫学 ((一社)日本神経免疫学会)  27 ( 1 ) 123 - 123 2022.10

ISSN  0918-936X

抗MOG抗体関連疾患を対象とした全国疫学調査(一次調査報告)

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 桑原 聡, 中島 一郎

臨床神経学 ((一社)日本神経学会)  62 ( Suppl. ) S218 - S218 2022.10

ISSN  0009-918X

将来の妊娠に備えた精神科治療　プレコンセプションケア向上を目的としたパンフレットによる教育的介入

小川 道, 橋本 佐, 石井 宏樹, 関 亮太, 佐藤 愛子, 橘 真澄, 木村 敦史, 山崎 香織, 椿 佳那子, 田中 麻未, 佐藤 泰憲, 新津 富央, 中里 道子, 伊豫 雅臣

日本周産期メンタルヘルス学会学術集会抄録集 (日本周産期メンタルヘルス学会)  18回   93 - 93 2022.10

大規模レジストリデータベースを活用したALS治験(ROPALS試験)におけるロピニロール塩酸塩の有効性の検証

高橋 愼一, 森本 悟, 伊東 大介, 伊達 悠岳, 岡田 健佑, Chyi Muh Chai, 西山 亜由美, 鈴木 直輝, 平井 美和, 加部 泰明, 末松 誠, 陣崎 雅弘, 青木 正志, 佐藤 泰憲, 中原 仁, 鈴木 則宏, 岡野 栄之

脳循環代謝 ((一社)日本脳循環代謝学会)  34 ( 1 ) 142 - 142 2022.10

ISSN  0915-9401

大規模レジストリデータベース(PRO-ACT)を活用したALSに対するロピニロール塩酸塩の有効性の検証

森本 悟, 高橋 愼一, 伊東 大介, 伊達 悠岳, 岡田 健佑, Chai Muh Chy, 西山 亜由美, 鈴木 直輝, 平井 美和, 加部 泰明, 末松 誠, 陣崎 雅弘, 青木 正志, 佐藤 泰憲, 中原 仁, 鈴木 則宏, 岡野 栄之

神経治療学 ((一社)日本神経治療学会)  39 ( 6 ) S257 - S257 2022.10

ISSN  0916-8443

ベッド脚下に設置した荷重センサーを用いた非接触非拘束ベッドセンサーシステムによる腹部手術患者の術後体重変化、生活パターン変化の観察研究

田口 奈津子, 孫 慶淑, 多羅尾 健太郎, 波照間 友基, 佐藤 泰憲, 磯野 史朗

日本医療ガス学会学術大会・総会プログラム・抄録集 (日本医療ガス学会)  25回   33 - 33 2022.10

MOG抗体関連疾患(MOGAD)の臨床と病態　MOG抗体関連疾患の疫学と臨床像

中村 正史, 小川 諒, 藤盛 寿一, 鵜沢 顕之, 佐藤 泰憲, 長島 健悟, 栗山 長門, 中島 一郎

神経治療学 ((一社)日本神経治療学会)  39 ( 6 ) S196 - S196 2022.10

ISSN  0916-8443

Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria.

Ogawa Y, Dana R, Kim S, Jain S, Rosenblatt MI, Perez VL, Clayton JA, Alves M, Rocha EM, Amparo F, Seo KY, Wang Y, Shen J, Oh JY, Vanathi M, Nair S, Na KS, Riemens A, Sippel K, Soifer M, Wang S, Ferrer MT, Kim MK, Yoon CH, Yagi R, Hiratsuka R, Ogawa M, Shimizu E, Sato Y, Pflugfelder S, Tsubota K

The ocular surface  2022.09

ISSN  1542-0124

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慢性血栓塞栓性肺高血圧症に対する肺動脈バルーン形成術後の運動耐容能改善に寄与する因子の検討

醍醐 恭平, 勝俣 良紀, 江嵜 康将, 岩澤 佑治, 市原 元気, 三浦 光太郎, 川上 崇史, 佐藤 泰憲, 佐藤 和毅, 福田 恵一

日本心臓病学会学術集会抄録 ((一社)日本心臓病学会)  70回   O - 41 2022.09

乳幼児期アレルギー疾患に関わる養育者負担評価票の開発　予備調査から見えてきたもの

水野 友美, 長尾 みづほ, 中川 敦夫, 佐藤 泰憲, 藤澤 隆夫

日本小児アレルギー学会誌 ((一社)日本小児アレルギー学会)  36 ( 4 ) 394 - 394 2022.09

ISSN  0914-2649