Papers - Sato, Yasunori

WJOG13219G: The Efficacy and Safety of FOLFOXIRI or Doublet plus Anti-VEGF Therapy in Previously Untreated BRAF^V600E Mutant Metastatic Colorectal Cancer: A Multi-Institutional Registry-Based Study (BRACELET Study).

Shimozaki K, Hirata K, Sato T, Nakamura M, Kato K, Hirano H, Kumekawa Y, Hino K, Kawakami K, Kito Y, Matsumoto T, Kawakami T, Komoda M, Nagashima K, Sato Y, Yamazaki K, Hironaka S, Takaishi H, Hamamoto Y, Muro K

Clinical colorectal cancer  2022.08

ISSN  1533-0028

• Access to Document (DOI)

Balloon pulmonary angioplasty versus riociguat in inoperable chronic thromboembolic pulmonary hypertension (MR BPA): an open-label, randomised controlled trial.

Takashi Kawakami, Hiromi Matsubara, Toshiro Shinke, Kohtaro Abe, Shun Kohsaka, Kazuya Hosokawa, Yu Taniguchi, Hiroto Shimokawahara, Yoshitake Yamada, Masaharu Kataoka, Aiko Ogawa, Mitsushige Murata, Masahiro Jinzaki, Kenichi Hirata, Hiroyuki Tsutsui, Yasunori Sato, Keiichi Fukuda

The Lancet. Respiratory medicine  2022.08

ISSN  2213-2600

　View Summary

BACKGROUND: Treatment options for patients with chronic thromboembolic pulmonary hypertension ineligible for pulmonary endarterectomy (inoperable CTEPH) include balloon pulmonary angioplasty (BPA) and riociguat. However, these two treatment options have not been compared prospectively. We aimed to compare the safety and efficacy of BPA and riociguat in patients with inoperable CTEPH. METHODS: This open-label, randomised controlled trial was conducted at four high-volume CTEPH centres in Japan. Patients aged 20-80 years with inoperable CTEPH (mean pulmonary arterial pressure ≥25 to <60 mm Hg and pulmonary artery wedge pressure ≤15 mm Hg) and WHO functional class II or III were randomly assigned (1:1) to BPA or riociguat via a computer program located at the registration centre using a minimisation method with biased-coin assignment. In the BPA group, the aim was for BPA to be completed within 4 months of the initial date of the first procedure. BPA was repeated until mean pulmonary arterial pressure decreased to less than 25 mm Hg. The frequency of BPA procedures depended on the difficulty and number of the lesions. In the riociguat group, 1·0 mg riociguat was administered orally thrice daily. When the systolic blood pressure was maintained at 95 mm Hg or higher, the dose was increased by 0·5 mg every 2 weeks up to a maximum of 2·5 mg thrice daily; dose adjustment was completed within 4 months of the date of the first dose. The primary endpoint was change in mean pulmonary arterial pressure from baseline to 12 months, measured in the full analysis set (patients who were enrolled and randomly assigned to one of the study treatments, and had at least one assessment after randomisation). BPA-related complications and indices related to clinical worsening were recorded throughout the study period. Adverse events were recorded throughout the study period and evaluated in the safety analysis set (patients who were enrolled and randomely assigned to one of the study treatments, and had received part of or all the study treatments). This trial is registered in the Japan Registry of Clinical Trials (jRCT; jRCTs031180239) and is completed. FINDINGS: Between Jan 8, 2016, and Oct 31, 2019, 61 patients with inoperable CTEPH were enrolled and randomly assigned to BPA (n=32) or riociguat (n=29). Patients in the BPA group underwent an average of 4·7 (SD 1·6) BPA procedures. In the riociguat group, the mean maintenance dose was 7·0 (SD 1·0) mg/day at 12 months. At 12 months, mean pulmonary arterial pressure had improved by -16·3 (SE 1·6) mm Hg in the BPA group and -7·0 (1·5) mm Hg in the riociguat group (group difference -9·3 mm Hg [95% CI -12·7 to -5·9]; p<0·0001). A case of clinical worsening of pulmonary hypertension occurred in the riociguat group, whereas none occurred in the BPA group. The most common adverse event was haemosputum, haemoptysis, or pulmonary haemorrhage, affecting 14 patients (44%) in the BPA group and one (4%) in the riociguat group. In 147 BPA procedures done in 31 patients, BPA-related complications were observed in 17 procedures (12%) in eight patients (26%). INTERPRETATION: Compared with riociguat, BPA was associated with a greater improvement in mean pulmonary arterial pressure in patients with inoperable CTEPH at 12 months, although procedure-related complications were reported. These findings support BPA as a reasonable option for inoperable CTEPH in centres with experienced BPA operators, with attention to procedure-related complications. FUNDING: Bayer Yakuhin. TRANSLATION: For the Japanese translation of the abstract see Supplementary Materials section.

• Access to Document (DOI)

Synergistic Effect of Motivation for the Elderly and Support for Going out.

Yumi Mashimo, Saki Tsuchihashi, Kenta Tsutsui, Tomoyuki Arai, Yoshitaka Tsuji, Toshiaki Numai, Kazuo Kameda, Kyoko Nishizawa, Mami Kovacs, Shukichi Tanaka, Hiroki Watanabe, Yasushi Naruse, Mitsuyo Ohmura, Noriyuki Ishida, Toshiki Iwasaki, Gaku Hiruma, Naoki Miyazaki, Ryo Takemura, Kengo Nagashima, Yasunori Sato, Yui Ohtsu, Takashi Nakano, Naomi Aida, Isao Iizuka, Hiromi Kato, Yoshiki Kobayashi, Takaaki Senbonmatsu

Journal of personalized medicine 12 ( 8 )  2022.07

　View Summary

Maintaining a social environment that enables going out freely is important for older people and aids the prevention of frailty syndrome. However, losing a driver's license can increase the long-term care needs of older people. Therefore, outing support systems are important. However, the utilization rate of these systems is currently relatively low. We conducted a demonstration experiment among older people aged 70 years and over, living in Iruma City, Saitama Japan, by implementing the Choisoko outing support system developed by Aisin Co., Ltd., in conjunction with an approach for improving motivation. Using this system, elderly people were able to go shopping freely whenever they chose, without a driver's license. Participants in the demonstration experiment exhibited higher Functional Independence Measure scores after the intervention, irrespective of whether or not they used the Choisoko system. The number of uses per person increased over time, and the subjective well-being of Choisoko users improved. However, few male participants engaged with the system. Although improving motivation is important for inducing positive behaviors and enabling the elderly to go out, motivation-improving factors differ between men and women.

• Access to Document (DOI)

Trends in the incidence and etiology of acute pancreatitis from 2000 to 2016: A population-based study.

Horibe M, Ravella B, Chandra S, Sharma A, Sato Y, Vege SS

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]  2022.07

ISSN  1424-3903

• Access to Document (DOI)

Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine.

Uwamino Y, Kurafuji T, Takato K, Sakai A, Tanabe A, Noguchi M, Yatabe Y, Arai T, Ohno A, Tomita Y, Shibata A, Yokota H, Yamasawa W, Namkoong H, Sato Y, Hasegawa N, Wakui M, Murata M, Keio Donner Project Team.

Vaccine  2022.06

ISSN  0264-410X

• Access to Document (DOI)

The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.

Inagaki E, Arai E, Hatou S, Sayano T, Taniguchi H, Negishi K, Kanai Y, Sato Y, Okano H, Tsubota K, Shimmura S

Stem cells translational medicine  2022.06

ISSN  2157-6564

• Access to Document (DOI)

Rocuronium versus saline for effective facemask ventilation during anesthesia induction: a double-blinded randomized placebo-controlled trial.

Ide A, Nozaki-Taguchi N, Sato S, Saito K, Sato Y, Isono S

BMC anesthesiology 22 ( 1 ) 173 2022.06

• Access to Document (DOI)

【こころの臨床現場からの発信"いま"をとらえ、精神療法の可能性を探る】(第1部)臨床現場からの声　精神療法の可能性を探る　本邦における集団精神療法の現状と課題

藤澤 大介, 田島 美幸, 田村 法子, 近藤 裕美子, 大嶋 伸雄, 岡島 美朗, 岡田 佳詠, 菊地 俊暁, 耕野 敏樹, 佐藤 泰憲, 高橋 章郎, 中川 敦夫, 中島 美鈴, 横山 貴和子, 吉永 尚紀, 大野 裕

精神療法 ((株)金剛出版)   ( 増刊9 ) 98 - 103 2022.06

ISSN  0916-8710

EFFICACY AND SAFETY OF ADALIMUMAB WITH LOW AND HIGH DOSE-METHOTREXATE IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH INADEQUATE RESPONSE TO METHOTREXATE: THE RANDOMISED CONTROLLED MIRACLE STUDY

Tamai H., Ikeda K., Miyamoto T., Taguchi H., Kuo C. F., Shin K., Hirata S., Okano Y., Sato S., Yasuoka H., Choi I. A., Park S. H., Weng M. Y., Kuwana M., Lee Y. J., Ishii T., Kim J., Kameda H., Kojima T., Baek H. J., Hsu P. N., Huang C. M., Cheng T. T., Sung W. Y., Taninaga T., Mori M., Miyagishi H., Sato Y., Takeuchi T., Kaneko Y.

ANNALS OF THE RHEUMATIC DISEASES 81   42 - 43 2022.06

ISSN  0003-4967

• Access to Document (DOI)

計算機科学を活用したヒトの有害事象研究の現状と展望　医療個別化のための臨床試験情報の系統的解析　慢性心不全患者の運動トレーニングの効果は薬物療法や病態に依存する

副島 裕佳子, 吉岡 秀樹, 佐藤 洋美, 畔 さゆり, 畠山 浩人, 佐藤 泰憲, 藤本 善英, 安西 尚彦, 樋坂 章博

The Journal of Toxicological Sciences ((一社)日本毒性学会)  47 ( Suppl. ) S27 - S27 2022.06

ISSN  0388-1350

Osteoporosis in nontuberculous mycobacterial pulmonary disease: a cross-sectional study.

Tanaka H, Asakura T, Suzuki S, Okamori S, Kusumoto T, Ogawa T, Uno S, Morita A, Lee H, Namkoong H, Kamata H, Sato Y, Uwamino Y, Nishimura T, Ishii M, Fukunaga K, Hasegawa N

BMC pulmonary medicine 22 ( 1 ) 202 2022.05

• Access to Document (DOI)

Combination therapy of high-flow nasal cannula and upper body elevation for postoperative sleep disordered breathing; randomized cross-over trial.

Sakaguchi Y, Nozaki-Taguchi N, Hasegawa M, Ishibashi K, Sato Y, Isono S

Anesthesiology  2022.04

ISSN  0003-3022

• Access to Document (DOI)

The associated factors of low birthweight among term singletons in Japan: a pregnancy birth registry analysis.

Kasuga Y, Iida M, Tanaka Y, Tamagawa M, Hasegawa K, Ikenoue S, Sato Y, Tanaka M, Ochiai D

Journal of epidemiology  2022.04

ISSN  0917-5040

• Access to Document (DOI)

トホグリフロジンによる糖尿病大血管症の進展抑制効果の検討　UTOPIA Extension study

片上 直人, 三田 智也, 吉井 秀徳, 白岩 俊彦, 安田 哲行, 岡田 洋右, 黒住 旭, 馬屋原 豊, 金藤 秀明, 遅野井 健, 山本 恒彦, 栗林 伸一, 前田 和久, 横山 宏樹, 小杉 圭右, 林 功, 住谷 哲, 津川 真美子, 良本 佳代子, 加藤 研, 中村 正, 川嶋 聡, 佐藤 泰憲, 綿田 裕孝, 下村 伊一郎

糖尿病 ((一社)日本糖尿病学会)  65 ( Suppl.1 ) S - 143 2022.04

ISSN  0021-437X

The cut-off values of vitamin D deficiency in early infancy.

Ikeda K, Hara-Isono K, Takahashi K, Arimitsu T, Sato Y

Pediatrics and neonatology  2022.03

ISSN  1875-9572

• Access to Document (DOI)

ファーマコメトリクス解析による医療個別化の推進　臨床試験個別データの精密解析に基づく慢性心不全患者に対する運動トレーニングの効果予測スコアの開発

吉岡 英樹, 副島 裕佳子, 畔 さゆり, 佐藤 洋美, 畠山 浩人, 佐藤 泰憲, 藤本 喜英, 安西 尚彦, 樋坂 章博

日本薬学会年会要旨集 ((公社)日本薬学会)  142年会   S04 - 2 2022.03

ISSN  0918-9823

The effect of the E484K mutation of SARS-CoV-2 on the neutralizing activity of antibodies from BNT162b2 vaccinated individuals.

Uwamino Y, Yokoyama T, Shimura T, Nishimura T, Sato Y, Wakui M, Kosaki K, Hasegawa N, Murata M

Vaccine  2022.02

ISSN  0264-410X

• Access to Document (DOI)

False lumen being larger than true lumen is associated with late aortic events in uncomplicated type B aortic dissection.

Matsushita A, Tabata M, Hattori T, Mihara W, Sato Y

Interactive cardiovascular and thoracic surgery  2022.02

ISSN  1569-9293

• Access to Document (DOI)

Evaluation of the effect of tofogliflozin on the tissue characteristics of the carotid wall-a sub-analysis of the UTOPIA trial.

Katakami N, Mita T, Maeda N, Sato Y, Watada H, Shimomura I, UTOPIA Study Investigators.

Cardiovascular diabetology 21 ( 1 ) 19 2022.02

• Access to Document (DOI)

WJOG13219G: Triplet versus doublet in patients with previously untreated BRAF(V600E)-mutant metastatic colorectal cancer: A multi-institutional real-world data analysis (BRACELET study)

Shimozaki Keitaro, Hirata Kenro, Sato Tarou, Nakamura Maho, Kato Kyoko, Hirano Hidekazu, Kumekawa Yosuke, Hino Kaori, Kawakami Kentaro, Kito Yosuke, Matsumoto Toshihiko, Kawakami Takeshi, Komoda Masato, Nagashima Kengo, Sato Yasunori, Yamazaki Kentaro, Hironaka Shuichi, Hamamoto Yasuo, Takaishi Hiromasa, Muro Kei

JOURNAL OF CLINICAL ONCOLOGY 40 ( 4 )  2022.02

ISSN  0732-183X

• Access to Document (DOI)