Papers - Sato, Yasunori

"Spike" in acute asthma exacerbations during enterovirus D68 epidemic in Japan: A nation-wide survey

Korematsu, Seigo, Nagashima, Kengo, Sato, Yasunori, Nagao, Mizuho, Hasegawa, Shunji, Nakamura, Haruna, Sugiura, Shiro, Miura, Katsushi, Okada, Kenji, Fujisawa, Takao

ALLERGOLOGY INTERNATIONAL (Allergology International)  67 ( 1 ) 55 - 60 2018.01

Research paper (scientific journal), Joint Work,  ISSN  1323-8930

　View Summary

© 2017 Japanese Society of Allergology Background In September 2015, Japan experienced an unusual increase in acute asthma hospitalizations of children that coincided with an enterovirus D68 (EV-D68) epidemic. The objective of this study is to investigate whether EV-D68 had a causal relationship with the spike in asthma hospitalizations. Methods A nation-wide retrospective survey of asthma hospitalizations of children was performed for the period from January 2010 through October 2015. The Japanese Society of Pediatric Allergy and Clinical Immunology asked its affiliated hospitals to report monthly numbers of hospitalizations, ICU admissions and mechanical ventilations due to acute asthma exacerbation. The data were retrieved from medical databases using predefined search criteria: diagnosis of asthma or asthmatic bronchitis, admission, and age <20 years. Monthly numbers of EV-D68 detection were also obtained from the Infectious Disease Surveillance Center of Japan. A Granger causality test was used to analyze the association of EV-D68 detections for asthma exacerbation. Results A total of 157 hospitals reported 87,189 asthma hospitalizations, including 477 ICU admissions and 1193 mechanical ventilations, during the survey period of 5 years and 10 months. The numbers of these events increased drastically in September 2015. The Granger causality test verified the association between EV-D68 and asthma hospitalizations/mechanical ventilations. The most-affected age group was 3–6 years old. Conclusions The spike in pediatric asthma hospitalizations in Japan in September 2015 was found to be associated with the EV-D68 epidemic. Respiratory pathogens can cause “epidemics” of asthma exacerbation. Coordinated surveillance of infectious diseases and asthma may be beneficial for prevention and better control of both illnesses.

• Access to Document (DOI)

Randomised controlled trial on the effect of internet-delivered computerised cognitive-behavioural therapy on patients with insomnia who remain symptomatic following hypnotics: a study protocol

Sato, Daisuke, Yoshinaga, Naoki, Nagai, Eiichi, Hanaoka, Hideki, Sato, Yasunori, Shimizu, Eiji

BMJ OPEN (BMJ Open)  8 ( 1 ) 199 - 205 2018.01

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

　View Summary

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Insomnia has severe consequences for health. Primary care physicians in Japan commonly provide hypnotics, which is far from optimal. The recommended treatment for insomnia is cognitive-behavioural therapy (CBT). Access to trained therapists, however, is limited. Rather than face-to-face CBT, several researchers have studied internet-delivered computerised CBT (ICBT). This paper describes the study protocol for a randomised controlled trial (RCT) to evaluate effectiveness and feasibility of our newly developed five-step ICBT as an adjunct to usual care (UC) compared with UC alone for patients with insomnia who remain symptomatic following hypnotics. Methods and analysis This proposed exploratory RCT comprises two parallel groups (ICBT+UC and UC alone) consisting of 15 participants each (n=30) diagnosed with insomnia who remain symptomatic after pharmacotherapy. We aim to evaluate the effectiveness of six intervention weeks. The primary outcome of insomnia severity will be the Pittsburgh Sleep Quality Index (PSQI) at week 6. Secondary outcomes include sleep onset latency, total sleep time, sleep efficiency extracted from PSQI, current feeling of refreshment and perceived soundness of sleep measured using visual analogue scale, number of awakenings, anxiety by Hospital Anxiety and Depression Scale, depression by Center for Epidemiologic Studies Depression Scale and quality of life by Euro Qol-5D. All measures will be assessed at weeks 0 (baseline), 6 (postintervention) and 12 (follow-up), and intention-to-treat analysis will be applied. The statistical analysis plan has been developed considering design of field materials. Ethics and dissemination This study will be conducted at the academic outpatient clinic of Chiba University Hospital, Japan. Ethics approval was granted by the Institutional Review Board of Chiba University Hospital. All participants will be required to provide written informed consent. The trial will be implemented and reported in accordance with Consolidated Standards of Reporting Trials recommendations. Trial registration number UMIN000021509; Pre-results.

• Access to Document (DOI)

Dynamic behaviour of the soft palate during nasal positive pressure ventilation under anaesthesia and paralysis: comparison between patients with and without obstructive sleep-disordered breathing

Okuyama M., Kato S., Sato S., Okazaki J., Kitamura Y., Ishikawa T., Sato Y., Isono S.

British Journal of Anaesthesia (British Journal of Anaesthesia)  120 ( 1 ) 181 - 187 2018.01

ISSN  00070912

　View Summary

© 2017 Background: Difficult mask ventilation is common and is known to be associated with sleep-disordered breathing (SDB). It is our hypothesis that the incidence of expiratory retropalatal (RP) airway closure (primary outcome) during nasal positive pressure ventilation (PPV) is more frequent in patients with SDB (apnea hypopnea index ≥5 h −1 ) than non-SDB subjects. Methods: The severity of SDB was assessed before surgery using a portable sleep monitor. In anaesthetized and paralysed patients with (n=11) and without SDB (n=9), we observed the behaviour of the RP airway endoscopically during nasal PPV with the mouth closed and determined the dynamic RP closing pressure, which was defined as the highest airway pressure above which the RP airway closure was reversed. The static RP closing pressure was obtained during cessation of mechanical ventilation in patients with dynamic RP closure during nasal PPV. Results: The expiratory RP airway closure accompanied by expiratory flow limitation occurred more frequently in SDB patients (9/11, 82%) than in non-SDB subjects (2/9, 22%; exact logistic regression analysis: P=0.022, odds ratio 3.6, 95% confidence interval 1.1–15.4). Receiver operating characteristic curve analyses indicated AHI >10h −1 and presence of habitual snoring as clinically useful predictors for the occurrence of RP closure during PPV. Dynamic RP closing pressure was greater than the static RP closing pressure by approximately 4–5 cm H 2 O. Conclusions: Valve-like dynamic RP closure that limits expiratory flow during nasal PPV occurs more frequently in SDB patients.

• Access to Document (DOI)

The prognostic significance of vasohibin-2 expression in patients with prostate cancer

Miyazaki Yasumasa, Kosaka Takeo, Mikami Shuji, Yasumizu Yota, Tanaka Nobuyuki, Kikuchi Eiji, Sato Yasufumi, Oya Mototsugu

CANCER SCIENCE 109   1070 - 1070 2018.01

ISSN  1349-7006

Non-Radiographic Measurement of Hallux Valgus Angle Using Self-Photography.

Yamaguchi S, Sadamasu A, Kimura S, Akagi R, Yamamoto Y, Sato Y, Sasho T, Ohtori S

J Orthop Sports Phys Ther (Journal of Orthopaedic and Sports Physical Therapy)  in press ( 2 ) 80 - 86 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  01906011

　View Summary

Copyright ©2019 Journal of Orthopaedic & Sports Physical Therapy. BACKGROUND: Radiographs of the feet are the reference standard for measuring the hallux valgus angle. However, the availability and use of radiographs are constrained due to cost and radiation exposure. Less invasive, nonradiographic assessments have been proposed, although measurement using self-photography has not been reported. t OBJECTIVES: To determine (1) reliability of photographic hallux valgus angle (pHVA) measurement using the same photographs of the feet, (2) reliability of repeated self-photography trials, and (3) measurement error when the radiographic hallux valgus angle (rHVA) is estimated using the pHVA. t METHODS: In this reliability study, participants took photographs of their own feet using a digital camera. The intrarater and interrater reliability of pHVA measurements were then assessed using the intraclass correlation coefficient (ICC) and 95% minimum detectable change (MDC). The participants took photographs twice, and the reliability of repeated self-photography trials was examined. Participants also received radiographs of their feet, from which the rHVA was measured. The measurement error was assessed using the mean difference and 95% limits of agreement. t RESULTS: The intrarater and interrater ICC of pHVA measurement was 0.99, with MDCs less tha 2°. The ICC of pHVA measurement for repeated self-photography was 0.96, and the MDC was 6.9° The pHVA was systematically lower than the rHVA by 5.3°. t CONCLUSION: Measurement of the pHVA using self-photography was reproducible, althoug pHVA measurement underestimated the rHVA. Th pHVA can be a useful nonradiographic method to uantify hallux valgus deformity.

• Access to Document (DOI)

Gastroduodenal Ulcers and ABO Blood Group: the Japan Nurses' Health Study (JNHS)

Alkebsi, Lobna, Ideno, Yuki, Lee, Jung-Su, Suzuki, Shosuke, Nakajima-Shimada, Junko, Ohnishi, Hiroshi, Sato, Yasunori, Hayashi, Kunihiko

JOURNAL OF EPIDEMIOLOGY (Journal of Epidemiology)  28 ( 1 ) 34 - 40 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  0917-5040

　View Summary

© © 2017 Lobna Alkebsi et al. Background: Although several studies have shown that blood type O is associated with increased risk of peptic ulcer, few studies have investigated these associations in Japan. We sought to investigate the association between the ABO blood group and risk of gastroduodenal ulcers (GDU) using combined analysis of both retrospective and prospective data from a large cohort study of Japanese women, the Japan Nurses’ Health Study (JNHS; n = 15,019). Methods: The impact of the ABO blood group on GDU risk was examined using Cox regression analysis to estimate hazard ratios (HRs) and 95% confidence intervals (CI), with adjustment for potential confounders. Results: Compared with women with non-O blood types (A, B, and AB), women with blood type O had a significantly increased risk of GDU from birth (multivariable-adjusted HR 1.18; 95% CI, 1.04–1.34). Moreover, the highest cumulative incidence of GDU was observed in women born pre-1956 with blood type O. In a subgroup analysis stratified by birth year (pre-1956 or post-1955), the multivariable-adjusted HR of women with blood type O was 1.22 (95% CI, 1.00–1.49) and 1.15 (95% CI, 0.98–1.35) in the pre-1956 and post-1955 groups, respectively. Conclusion: In this large, combined, ambispective cohort study of Japanese women, older women with blood type O had a higher risk of developing GDU than those with other blood types.

• Access to Document (DOI)

Internet-Based Cognitive Behavioral Therapy With Real-Time Therapist Support via Videoconference for Patients With Obsessive-Compulsive Disorder, Panic Disorder, and Social Anxiety Disorder: Pilot Single-Arm Trial

Matsumoto K, Sutoh C, Asano K, Seki Y, Urao Y, Yokoo M, Takanashi R, Yoshida T, Tanaka M, Noguchi R, Nagata S, Oshiro K, Numata N, Hirose M, Yoshimura K, Nagai K, Sato Y, Kishimoto T, Nakagawa A, Shimizu E.

J Med Internet Res (Journal of Medical Internet Research)  20 ( 12 ) e12091 2018

Research paper (scientific journal), Joint Work, Accepted

　View Summary

© 2018 Journal of Medical Internet Research. All rights reserved. Background: Cognitive behavioral therapy (CBT) is the first-line treatment for adults with obsessive-compulsive disorder (OCD), panic disorder (PD), and social anxiety disorder (SAD). Patients in rural areas can access CBT via the internet. The effectiveness of internet-delivered cognitive behavioral therapy (ICBT) has been consistently shown, but no clinical studies have demonstrated the feasibility of ICBT with real-time therapist support via videoconference for OCD, PD, and SAD at the same time. Objectives: This study aimed to evaluate the feasibility of videoconference-delivered CBT for patients with OCD, PD, or SAD. Methods: A total of 30 Japanese participants (mean age 35.4 years, SD 9.2) with OCD, SAD, or PD received 16 sessions of individualized videoconference-delivered CBT with real-time support of a therapist, using tablet personal computer (Apple iPad Mini 2). Treatment involved individualized CBT formulations specific to the presenting diagnosis; all sessions were provided by the same therapist. The primary outcomes were reduction in symptomatology, using the Yale-Brown obsessive-compulsive scale (Y-BOCS) for OCD, Panic Disorder Severity Scale (PDSS) for PD, and Liebowitz Social Anxiety Scale (LSAS) for SAD. The secondary outcomes included the EuroQol-5 Dimension (EQ-5D) for Quality of Life, the Patient Health Questionnaire (PHQ-9) for depression, the Generalized Anxiety Disorder (GAD-7) questionnaire for anxiety, and Working Alliance Inventory-Short Form (WAI-SF). All primary outcomes were assessed at baseline and at weeks 1 (baseline), 8 (midintervention), and 16 (postintervention) face-to-face during therapy. The occurrence of adverse events was observed after each session. For the primary analysis comparing between pre- and posttreatments, the participants' points and 95% CIs were estimated by the paired t tests with the change between pre- and posttreatment. Results: A significant reduction in symptom of obsession-compulsion (Y-BOCS=-6.2; Cohen d=0.74; 95% CI -9.4 to -3.0, P=.002), panic (PDSS=-5.6; Cohen d=0.89; 95% CI -9.83 to -1.37; P=.02), social anxiety (LSAS=-33.6; Cohen d=1.10; 95% CI -59.62 to -7.49, P=.02) were observed. In addition, depression (PHQ-9=-1.72; Cohen d=0.27; 95% CI -3.26 to -0.19; P=.03) and general anxiety (GAD-7=-3.03; Cohen d=0.61; 95% CI -4.57 to -1.49, P<.001) were significantly improved. Although there were no significant changes at 16 weeks from baseline in EQ-5D (0.0336; Cohen d=-0.202; 95% CI -0.0198 to 0.00869; P=.21), there were high therapeutic alliance (ie, WAI-SF) scores (from 68.0 to 73.7) throughout treatment, which significantly increased (4.14; 95% CI 1.24 to 7.04; P=.007). Of the participants, 86% (25/29) were satisfied with videoconference-delivered CBT, and 83% (24/29) preferred videoconference-delivered CBT to face-to-face CBT. An adverse event occurred to a patient with SAD; the incidence was 3% (1/30). Conclusions: Videoconference-delivered CBT for patients with OCD, SAD, and SAD may be feasible and acceptable.

• Access to Document (DOI)

Genomic Comparison With Supercentenarians Identifies RNF213 as a Risk Gene for Pulmonary Arterial Hypertension

174. Suzuki H, Kataoka M, Hiraide T, Aimi Y, Yamada Y, Katsumata Y, Chiba T, Kanekura K, Isobe S, Sato Y, Satoh T, Gamou S, Fukuda K, Kosaki K

Circ Genom Precis Med 11 ( 12 ) e002317 2018

Research paper (scientific journal), Joint Work, Accepted

Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial

173. Miyakawa A, Kodera S, Sakuma Y, Shimada T, Kubota M, Nakamura A, Itobayashi E, Shimura H, Suzuki Y, Sato Y, Shimura K

Digestion  2018

Research paper (scientific journal), Joint Work, Accepted

Efficacy of foot orthoses as nonoperative treatment for hallux valgus: A 2-year follow-up study

Nakagawa R, Yamaguchi S, Kimura S, Sadamasu A, Yamamoto Y, Muramatsu Y, Sato Y, Akagi R, Sasho T, Ohtori S.

J Orthop Sci (Journal of Orthopaedic Science)  24 ( 3 ) 526 - 531 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  09492658

　View Summary

© 2018 Background: The purpose of this study was to clarify the 2-year clinical and radiological outcomes of nonoperative treatment using foot orthosis for hallux valgus patients. Methods: Patients who underwent nonoperative treatment using foot orthosis were surveyed prospectively. Foot orthoses were made by one certified orthotist using the standardized method. Pain and quality of life were evaluated using subjective and objective assessment measures at 3, 6, 12, 18, and 24 months. Furthermore, radiological outcomes, patient satisfaction, and adherence to treatment were surveyed. Results: A total of 53 patients (50 women and 3 men; median age, 63 years) were included for analysis. The pain visual analogue scale score significantly decreased over time, with the lowest score observed at 12 months. The treatment effect was maintained over 24 months (median score, 52, 21, and 27 points at baseline, 12 months, and 24 months, respectively; P < .001). The Japanese Society for Surgery of the Foot hallux scale, American Academy of Orthopaedic Surgeons Foot and Ankle Scale, and 36-Item Short-Form Health Survey bodily pain subscale also improved, although the treatment effects were maximal at 6 months and decreased thereafter. At 24 months, 43 (81%) patients continued to use the orthosis, with the median visual analogue scale score for patient satisfaction of 76 points. The hallux valgus angle and intermetatarsal angle did not change during the 24-month period. Conclusion: Nonoperative treatment using foot orthoses decreased pain in patients with hallux valgus. The effect of treatment was maintained up to 2 years with a relatively high degree of patient satisfaction. However, treating physicians should inform patients to set realistic expectations and be aware that a limited degree of pain reduction is expected.

• Access to Document (DOI)

Complications after stereotactic radiosurgery for brain metastases: Incidences, correlating factors, treatments and outcomes

168. Aiyama H, Yamamoto M, Kawabe T, Watanabe S, Koiso T, Sato Y, Higuchi Y, Ishikawa E, Yamamoto T, Matsumura A, Kasuya H, Barfod BE

Radiother Oncol (Radiotherapy and Oncology)  129 ( 2 ) 103 - 110 2018

Research paper (scientific journal), Joint Work, Accepted,  ISSN  01678140

　View Summary

© 2018 Elsevier B.V. Background and purpose: Complications after stereotactic radiosurgery (SRS) for brain metastases (BMs) were analyzed in detail using our database including nearly 3000 BM patients. Materials and methods: This was an institutional review board-approved, retrospective cohort study using our prospectively accumulated database including 3271 consecutive patients who underwent gamma knife SRS for BMs during the 1998–2016 period. Excluding four patients lost to follow-up, 112 with three-staged treatment and 189 with post-operative irradiation, 2966 who underwent a single-session of SRS only as radical irradiation were studied. Results: The overall median survival time after SRS was 7.8 (95% CI; 7.4–8.1) months. Post-SRS complications occurred in 86 patients (2.9%) 1.9–211.4 (median; 24.0, IQR; 12.0–64.6) months after treatment. RTOG neurotoxicity grades were 2, 3 and 4 in 58, 25 and 3 patients, respectively. Cumulative incidences determined with a competing risk analysis were 1.4%, 2.2%, 2.4%, 2.6% and 2.9% at the 12th, 24th, 36th, 48th and 60th post-SRS month, respectively. Among various pre-SRS clinical factors and radiosurgical parameters, multivariable analyses demonstrated solitary tumor (Adjusted HR; 0.584, 95% CI; 0.381–0.894, p = 0.0133), controlled primary cancer (Adjusted HR; 2.595, 95% CI; 1.646–4.091, p < 0.0001), no extra-cerebral metastases (Adjusted HR; 1.608, 95% CI; 1.028–2.514, p = 0.0374), KPS ≥80% (Adjusted HR; 2.715, 95% CI; 1.245–5.924, p = 0.0121) and largest tumor volume ≥3.3 cc (Adjusted HR; 0.516, 95% CI; 0.318–0.836, p = 0.0072) to be independently significant predictors of a higher incidence of complications. Conclusion: The post-SRS complication incidence is acceptably low (2.9%). Meticulous long-term follow-up after SRS is crucial for all patients.

• Access to Document (DOI)

Comparison of treatment results between 3- and 2-stage Gamma Knife radiosurgery for large brain metastases: a retrospective multi-institutional study

Serizawa T, Higuchi Y, Yamamoto M, Matsunaga S, Nagano O, Sato Y, Aoyagi K, Yomo S, Koiso T, Hasegawa T, Nakazaki K, Moriki A, Kondoh T, Nagatomo Y, Okamoto H, Kohda Y, Kawai H, Shidoh S, Shibazaki T, Onoue S, Kenai H, Inoue A, Mori H

J Neurosurg    1 - 11 2018

Research paper (scientific journal), Joint Work, Accepted

Survey of Anticonvulsant Drugs and Lithium Prescription in Women of Childbearing age in Japan Using a Public National Insurance Claims Database

Yoshimura Kensuke, Hashimoto Tasuku, Sato Yasunori, Sato Aiko, Takeuchi Takashi, Watanabe Hiroyuki, Terao Takeshi, Nakazato Michiko, Iyo Masaomi

Clinical Neuropsychopharmacology and Therapeutics (日本臨床精神神経薬理学会)  9 ( 0 ) 20 - 28 2018

　View Summary

<p>Purpose: Pharmacological treatments with some anticonvulsants, including valproate, and lithium should be avoided where possible in childbearing-aged and pregnant women with epilepsy and bipolar disorder because they increase the risk of major congenital malformations. We surveilled real-world prescriptions of anticonvulsants and lithium in childbearing-aged female and male outpatients in Japan, using the first public National Insurance Claims Database of Japan.</p><p>Methods: We performed a summary statistical analysis of the numbers of the most prescribed 11 anticonvulsants and lithium tablets in female and male outpatients aged 15-29 (younger childbearing age), 30-49 (older childbearing age), and >50 (non-childbearing age) years from April 2014 to March 2015. We determined the association between anticonvulsant or lithium use and sex at childbearing age, and the odds ratio (OR) and 95% confidence intervals (CIs) were estimated using logistic regression analysis.</p><p>Results: Valproate (number of tablets = 273,135,937) was the most prescribed among the 12 investigated drugs, and 125,451,907 tablets were prescribed for women (younger, older, and non-childbearing ages, 19,296,528, 47,826,746, and 58,328,63, respectively), compared to 147,684,031 tablets for men (24,534,648, 57,229,981, and 65,919,402, respectively). Valproate prescription was only slightly lower in childbearing-aged women than in the same-aged men (i.e., 15-29 years of age, OR = 0.889 [95% CI, 0.888-0.890]; 30-49 years of age, OR = 0.944 [95% CI, 0.944-0.945]).</p><p>Discussion: This study demonstrated valproate was highly prescribed for childbearing-aged women in Japan in 2014-2015. Physicians should prescribe valproate with considerable caution in girls and childbearing-aged women.</p>

• Access to Document (DOI)

Association of locomotive syndrome with present and past physical activities, and self-reported gait speed: A cross sectional study

Yamaguchi S., Kishida S., Yamazaki N., Sato Y., Shirai T., Akagi R., Sasho T., Ohtori S., Takahashi K.

Chiba Medical Journal (Chiba Medical Journal)  94E   9 - 17 2018

ISSN  03035476

　View Summary

The purpose of this study was to clarify the association of locomotive syndrome with present and past physical activities, as well as gait speed. Subjects were recruited from the participants of the specific health checkups in Oamishirasato City. The presence of locomotive syndrome was assessed using the stand-up test, two-step test, and 25-question geriatric locomotive function scale. Present physical activity was measured using the International Physical Activity Questionnaire. Questionnaires were also used to assess past physical activity and usual gait speed. The association of each locomotive syndrome risk test with the physical activities and gait speed was examined using univariate analysis and multiple logistic regression analysis. A total of 172 subjects with a mean age of 67.5 years were enrolled. Sixty-nine（40%）and 13（8%）subjects were classified as having stage 1 and 2 locomotive syndrome, respectively. Among the four groups classified by physical activity level, the proportions of subjects with positive stand-up test were higher in the groups of lowest and highest physical activity（P＝0.048）. Faster gait speed was a significant predictor of the negative two-step test（P＝0.08）, negative 25-question geriatric locomotive function scale（P＜0.001）, and absence of locomotive syndrome（P＝0.002）. The associations remained significant in the multiple regression analysis, after adjusting for age, sex, and body mass index. In conclusion, present physical activity was associated with the stand-up test, whereas self-reported usual gait speed was associated with the two-step test and 25-question geriatric locomotive function scale.

• Access to Document (DOI)

Predictors of primary lung cancer in a solitary pulmonary lesion after a previous malignancy

Nakadate, A., Nakadate, M., Sato, Y., Nakagawa, T., Yoshida, K., Suzuki, Y. and Yoshida, Y.

Gen Thorac Cardiovasc Surg 65 ( 12 ) 698 - 704 2017.12

Research paper (scientific journal), Joint Work,  ISSN  1863-6705

　View Summary

OBJECTIVE: A solitary pulmonary lesion in patients with a history of malignancy may be either primary lung cancer or a metastatic lung tumor or benign nodule. We retrospectively examined the preoperative predictive factors for determining the type of pathology. METHODS: We used an exact logistic regression analysis to identify radiological and clinical predictors of primary lung cancer. The study included 187 patients who underwent pulmonary resection for a solitary pulmonary lesion and had received previous treatment for a malignancy. RESULTS: There were 107 patients with primary lung cancer, 74 with metastatic lung tumors, and 6 with benign lesions. The previous malignancy included colorectal cancer in 71 patients. A disease-free interval exceeding 5 years and ground-glass opacity were found in 27.0% (20/74) and 1.4% (1/74) of metastatic lung tumors, respectively. Multivariate logistic regression analysis demonstrated that spiculation [adjusted odds ratio (a-OR), 1.74; 95% confidence interval (CI), 1.09-2.86], pleural indentation (a-OR 1.99, 95% CI 1.24-3.29), and ground-glass opacity (a-OR 5.28, 95% CI 2.61-13.1) on high-resolution computed tomography, maximum standardized uptake value (a-OR 1.14, 95% CI 1.02-1.29), current and former smokers (a-OR 1.96, 95% CI 1.21-3.30), and previous malignancy other than colorectal cancer (a-OR 2.02, 95% CI 1.26-3.37) were associated with primary lung cancer. CONCLUSIONS: A combination of radiological findings, smoking history, and type of previous malignancy can improve the ability to predict primary lung cancer in the presence of a solitary pulmonary lesion that appears after previous treatment for a malignancy.

• Access to Document (DOI)

Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial

Furuta S, Sugiyama T, Umibe T, Kaneko Y, Amano K, Kurasawa K, Nakagomi D, Hanaoka H, Sato Y, Ikeda K, Nakajima H and on behalf of the LoVAS Trial study investigators

BMJ OPEN 7 ( 12 ) 55 - 60 2017.12

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

• Access to Document (DOI)

Loose Lips Are Actually Good Reply

Isono, Shiroh, Sato, Shin, Hasegawa, Makoto, Okuyama, Megumi, Okazaki, Junko, Kitamura, Yuji, Sato, Yumi, Ishikawa, Teruhiko, Sato, Yasunori

ANESTHESIOLOGY 127 ( 5 ) 897 - 898 2017.11

Research paper (scientific journal), Joint Work,  ISSN  0003-3022

A clinical predictive score for postoperative myasthenic crisis

Kanai, Tetsuya, Uzawa, Akiyuki, Sato, Yasunori, Suzuki, Shigeaki, Kawaguchi, Naoki, Himuro, Keiichi, Oda, Fumiko, Ozawa, Yukiko, Nakahara, Jin, Suzuki, Norihiro, Takahashi, Yuko K., Ishibashi, Satoru, Yokota, Takanori, Ogawa, Takashi, Yokoyama, Kazumasa, Hattori, Nobutaka, Izaki, Shoko, Oji, Satoru, Nomura, Kyoichi, Kaneko, Juntaro, Nishiyama, Kazutoshi, Yoshino, Ichiro, Kuwabara, Satoshi

ANNALS OF NEUROLOGY 82 ( 5 ) 841 - 849 2017.11

Research paper (scientific journal), Joint Work,  ISSN  0364-5134

• Access to Document (DOI)

Current Status and Open Issues Concerning Global Clinical Trials (GCTs) in Japan and East Asia

Miyazaki, Koichi, Sato, Yasunori, Hanaoka, Hideki, Uyama, Yoshiaki

CTS-CLINICAL AND TRANSLATIONAL SCIENCE 10 ( 6 ) 503 - 508 2017.11

Research paper (scientific journal), Joint Work,  ISSN  1752-8054

• Access to Document (DOI)

Association of Anxiety and Depression With Pain and Quality of Life in Patients With Chronic Foot and Ankle Diseases

Nakagawa, Ryosuke, Yamaguchi, Satoshi, Kimura, Seiji, Sadamasu, Aya, Yamamoto, Yohei, Sato, Yasunori, Akagi, Ryuichiro, Sasho, Takahisa, Ohtori, Seiji

FOOT & ANKLE INTERNATIONAL 38 ( 11 ) 1192 - 1198 2017.11

Research paper (scientific journal), Joint Work,  ISSN  1071-1007

• Access to Document (DOI)