Papers - Sato, Yasunori

Application of Akaike information criterion to evaluate warfarin dosing algorithm

Harada, Takumi, Ariyoshi, Noritaka, Shimura, Hitoshi, Sato, Yasunori, Yokoyama, Iichiro, Takahashi, Kaori, Yamagata, Shin-ichi, Imamaki, Mizuho, Kobayashi, Yoshio, Ishii, Itsuko, Miyazaki, Masaru, Kitada, Mitsukazu

THROMBOSIS RESEARCH 126 ( 3 ) 183 - 190 2010.09

Research paper (scientific journal), Joint Work,  ISSN  0049-3848

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Detection of inappropriate samples in association studies by an IBS-based method considering linkage disequilibrium between genetic markers

Andoh, Masataka, Sato, Yasunori, Sakamoto, Hiromi, Yoshida, Teruhiko, Ohtaki, Megu

JOURNAL OF HUMAN GENETICS 55 ( 7 ) 436 - 440 2010.07

Research paper (scientific journal), Joint Work,  ISSN  1434-5161

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Biostatistic Tools in Pharmacogenomics - Advances, Challenges, Potential

Sato, Yasunori, Laird, Nan M., Yoshida, Teruhiko

CURRENT PHARMACEUTICAL DESIGN 16 ( 20 ) 2232 - 2240 2010.07

Research paper (scientific journal), Joint Work,  ISSN  1381-6128

Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese

Ariyoshi, Noritaka, Iga, Yukako, Hirata, Koji, Sato, Yasunori, Miura, Go, Ishii, Itsuko, Nagamori, Seiji, Kitada, Mitsukazu

DRUG METABOLISM AND PHARMACOKINETICS 25 ( 3 ) 298 - 306 2010

Research paper (scientific journal), Joint Work,  ISSN  1347-4367

Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies

14. Isose S, Kuwabara S, Kokubun N, Sato Y, Mori M, Shibuya K, Sekiguchi, Y, Nasu A, Fujimaki Y, Noto Y, Sawai S, Hirata K, Misawa S and The Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 14 ( 3 ) 151 - 158 2009.09

Research paper (scientific journal), Joint Work,  ISSN  1085-9489

The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: Multivariate analyses

Fujimaki, Yumi, Kuwabara, Satoshi, Sato, Yasunori, Isose, Sagiri, Shibuya, Kazumoto, Sekiguchi, Yukari, Nasu, Saiko, Noto, Yuichi, Taniguchi, Junko, Misawa, Sonoko

CLINICAL NEUROPHYSIOLOGY 120 ( 9 ) 1683 - 1686 2009.09

Research paper (scientific journal), Joint Work,  ISSN  1388-2457

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Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women

Sangrajrang, Suleeporn, Sato, Yasunori, Sakamoto, Hiromi, Ohnami, Sumiko, Laird, Nan M., Khuhaprema, Thiravud, Brennan, Paul, Boffetta, Paulo, Yoshida, Teruhiko

INTERNATIONAL JOURNAL OF CANCER 125 ( 4 ) 837 - 843 2009.08

Research paper (scientific journal), Joint Work,  ISSN  0020-7136

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Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia

Moriya, Junji, Minamino, Tohru, Tateno, Kaoru, Shimizu, Naomi, Kuwabara, Yoichi, Sato, Yasunori, Saito, Yasushi, Komuro, Issei

CIRCULATION-CARDIOVASCULAR INTERVENTIONS 2 ( 3 ) 245 - U157 2009.06

Research paper (scientific journal), Joint Work,  ISSN  1941-7640

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A new statistical screening approach for finding pharmacokinetics-related genes in genome-wide studies

Sato Y., Laird N., Nagashima A., Kato R., Hamano T., Yafune A., Kaniwa N., Saito Y., Sugiyama E., Kim S., Furuse J., Ishii H., Ueno H., Okusaka T., Saijo N., Sawada J., Yoshida T.

Pharmacogenomics Journal (Pharmacogenomics Journal)  9 ( 2 ) 137 - 146 2009.04

ISSN  1470269X

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Biomedical researchers usually test the null hypothesis that there is no difference of the population mean of pharmacokinetics (PK) parameters between genotypes by the Kruskal-Wallis test. Although a monotone increasing pattern with a number of alleles is expected for PK-related genes, the Kruskal-Wallis test does not consider a monotonic response pattern. For detecting such patterns in clinical and toxicological trials, a maximum contrast method has been proposed. We show how that method can be used with pharmacogenomics data to a develop test of association. Further, using simulation studies, we compare the power of the modified maximum contrast method to those of the maximum contrast method and the Kruskal-Wallis test. On the basis of the results of those studies, we suggest rules of thumb for which statistics to use in a given situation. An application of all three methods to an actual genome-wide pharmacogenomics study illustrates the practical relevance of our discussion.

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Report of trainee of the foreign clinical pharmacology training progiam no 4

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  40 ( 2 ) 75 - 78 2009.03

ISSN  03881601

Report of trainee of the foreign clinical pharmacology training program no 3

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  40 ( 2 ) 67 - 69 2009.03

ISSN  03881601

Statistical Screening Method for Genetic Factors Influencing Susceptibility to Common Diseases in a Two-Stage Genome-Wide Association Study

Sato, Yasunori, Laird, Nan, Suganami, Hideki, Hamada, Chikuma, Niki, Naoto, Yoshimura, Isao, Yoshida, Teruhiko

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 8 ( 1 ) 151 - 158 2009

Research paper (scientific journal), Joint Work,  ISSN  1544-6115

His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk

Ohnami, Shumpei, Sato, Yasunori, Yoshimura, Kimio, Ohnami, Sumiko, Sakamoto, Hiromi, Aoki, Kazunori, Ueno, Hideki, Ikeda, Masafumi, Morizane, Chigusa, Shimada, Kazuaki, Sakamoto, Yoshihiro, Esaki, Minoru, Saito, Ikuo, Hirose, Hiroshi, Saito, Daizo, Sugimura, Haruhiko, Kosuge, Tomoo, Okusaka, Takuji, Yoshida, Teruhiko

GASTROENTEROLOGY 135 ( 2 ) 477 - 488 2008.08

Research paper (scientific journal), Joint Work,  ISSN  0016-5085

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Report of Trainee of the Forein Clinical Pharmacology Training Program: No. 2

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  39 ( 4 ) 123 - 125 2008.07

ISSN  03881601

Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Sakamoto H, Yoshimura K, Saeki N, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S.

NATURE GENETICS 40 ( 6 ) 730 - 740 2008.06

Research paper (scientific journal), Joint Work,  ISSN  1061-4036

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Marked differences in differentiation propensity among human embryonic stem cell lines

Osafune, Kenji, Caron, Leslie, Borowiak, Malgorzata, Martinez, Rita J., Fitz-Gerald, Claire S., Sato, Yasunori, Cowan, Chad A., Chien, Kenneth R., Melton, Douglas A.

NATURE BIOTECHNOLOGY 26 ( 3 ) 313 - 315 2008.03

Research paper (scientific journal), Joint Work,  ISSN  1087-0156

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Report of Trainee of the Foreign Clinical Pharmacology Traininng Program: No. 1

Sato Y.

Japanese Journal of Clinical Pharmacology and Therapeutics (Japanese Journal of Clinical Pharmacology and Therapeutics)  39 ( 2 ) 81 - 83 2008.03

ISSN  03881601

A new test statistic based on shrunken sample variance for identifying differentially expressed genes in small microarray experiments

Hirakawa, A., Sato, Y., Hamada, C. and Yoshimura, I.

Bioinform Biol Insights 2   145 - 56 2008.02

Joint Work,  ISSN  1177-9322

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Choosing an appropriate statistic and precisely evaluating the false discovery rate (FDR) are both essential for devising an effective method for identifying differentially expressed genes in microarray data. The t-type score proposed by Pan et al. (2003) succeeded in suppressing false positives by controlling the underestimation of variance but left the overestimation uncontrolled. For controlling the overestimation, we devised a new test statistic (variance stabilized t-type score) by placing shrunken sample variances of the James-Stein type in the denominator of the t-type score. Since the relative superiority of the mean and median FDRs was unclear in the widely adopted Significance Analysis of Microarrays (SAM), we conducted simulation studies to examine the performance of the variance stabilized t-type score and the characteristics of the two FDRs. The variance stabilized t-type score was generally better than or at least as good as the t-type score, irrespective of the sample size and proportion of differentially expressed genes. In terms of accuracy, the median FDR was superior to the mean FDR when the proportion of differentially expressed genes was large. The variance stabilized t-type score with the median FDR was applied to actual colorectal cancer data and yielded a reasonable result.

Association of a missense single nucleotide polymorphism, Cys1367Arg of the WRN gene, with the risk of bone and soft tissue sarcomas in Japan

Nakayama, Robert, Sato, Yasunori, Masutani, Mitsuko, Ogino, Hideki, Nakatani, Fumihiko, Chuman, Hirokazu, Beppu, Yasuo, Morioka, Hideo, Yabe, Hiroo, Hirose, Hiroshi, Sugimura, Haruhiko, Sakamoto, Hiromi, Ohta, Tsutomu, Toyama, Yoshiaki, Yoshida, Teruhiko, Kawai, Akira

CANCER SCIENCE 99 ( 2 ) 333 - 339 2008.02

Research paper (scientific journal), Joint Work,  ISSN  1347-9032

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Estimating the false discovery rate using mixed normal distribution for identifying differentially expressed genes in microarray data analysis

Hirakawa, A., Sato, Y., Sozu, T., Hamada, C. and Yoshimura, I.

Cancer Inform 3   140 - 8 2008.01

Joint Work,  ISSN  1176-9351

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The recent development of DNA microarray technology allows us to measure simultaneously the expression levels of thousands of genes and to identify truly correlated genes with anticancer drug response (differentially expressed genes) from many candidate genes. Significance Analysis of Microarray (SAM) is often used to estimate the false discovery rate (FDR), which is an index for optimizing the identifiability of differentially expressed genes, while the accuracy of the estimated FDR by SAM is not necessarily confirmed. We propose a new method for estimating the FDR assuming a mixed normal distribution on the test statistic and examine the performance of the proposed method and SAM using simulated data. The simulation results indicate that the accuracy of the estimated FDR by the proposed method and SAM, varied depending on the experimental conditions. We applied both methods to actual data comprised of expression levels of 12,625 genes of 10 responders and 14 non-responders to docetaxel for breast cancer. The proposed method identified 280 differentially expressed genes correlated with docetaxel response using a cut-off value for achieving FDR <0.01 to prevent false-positive genes, although 92 genes were previously thought to be correlated with docetaxel response ones.