Papers - Sato, Yasunori

医学・薬学研究における生存時間データの統計解析

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 30 ( 5 ) 659 - 665 2016

Research paper (scientific journal), Joint Work, Accepted

医学・薬学研究における統計モデル解析. 日本小児アレルギー学会誌

佐藤泰憲, 高橋翔, 長島健悟

日本小児アレルギー学会誌 30 ( 4 ) 580 - 586 2016

Research paper (scientific journal), Joint Work, Accepted

Effects of low frequency filtering on distal compound muscle action potential duration for diagnosis of CIDP: A Japanese-European multicenter prospective study

Mitsuma S, Van den Bergh P, Rajabally YA, Van Parijs V, Martin-Lamb D, Sonoo M, Inaba A, Shimizu T, Isose S, Sato Y, Komori T, Misawa S, Kuwabara S; Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group

CLINICAL NEUROPHYSIOLOGY 126 ( 9 ) 1805 - 1810 2015.09

Research paper (scientific journal), Joint Work,  ISSN  1388-2457

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Shape of the lateral edge of the first metatarsal head changes depending on the rotation and inclination of the first metatarsal: a study using digitally reconstructed radiographs

Yamaguchi, Satoshi, Sasho, Takahisa, Endo, Jun, Yamamoto, Yohei, Akagi, Ryuichiro, Sato, Yasunori, Takahashi, Kazuhisa

JOURNAL OF ORTHOPAEDIC SCIENCE 20 ( 5 ) 868 - 874 2015.09

Research paper (scientific journal), Joint Work,  ISSN  0949-2658

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Quantitative Assessment of Tendon Healing by Using MR T2 Mapping in a Rabbit Achilles Tendon Transection Model Treated with Platelet-rich Plasma

Fukawa, Taisuke, Yamaguchi, Satoshi, Watanabe, Atsuya, Sasho, Takahisa, Akagi, Ryuichiro, Muramatsu, Yuta, Akatsu, Yorikazu, Katsuragi, Joe, Endo, Jun, Osone, Fumio, Sato, Yasunori, Okubo, Toshiyuki, Takahashi, Kazuhisa

RADIOLOGY 276 ( 3 ) 748 - 755 2015.09

Research paper (scientific journal), Joint Work,  ISSN  0033-8419

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Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice

Toyohara, Takafumi, Mae, Shin-lchi, Sueta, Shin-lchi, Inoue, Tatsuyuki, Yamagishi, Yukiko, Kawamoto, Tatsuya, Kasahara, Tomoko, Hoshina, Azusa, Toyoda, Taro, Tanaka, Hiromi, Araoka, Toshikazu, Sato-Otsubo, Aiko, Takahashi, Kazutoshi, Sato, Yasunori, Yamaji, Noboru, Ogawa, Seishi, Yamanaka, Shinya, Osafune, Kenji

STEM CELLS TRANSLATIONAL MEDICINE 4 ( 9 ) 980 - 992 2015.09

Research paper (scientific journal), Joint Work,  ISSN  2157-6564

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足部X線における第一中足骨頭の形状は、中足骨の回旋と傾斜により変化する デジタル再構成シミュレーション画像を用いた検討

山口 智志, 山本 陽平, 中川 量介, 佐藤 泰憲, 佐粧 孝久, 赤木 龍一郎, 星 裕子, 佐々木 俊英, 佐藤 祐介, 高橋 和久

日本足の外科学会雑誌 ((一社)日本足の外科学会)  36 ( 2 ) S186 - S186 2015.09

ISSN  0916-7927

A single blind randomized controlled clinical trial of mexiletine in amyotrophic lateral sclerosis: Efficacy and safety of sodium channel blocker phase II trial

Shibuya, Kazumoto, Misawa, Sonoko, Kimura, Hideki, Noto, Yu-Ichi, Sato, Yasunori, Sekiguchi, Yukari, Iwai, Yuta, Mitsuma, Satsuki, Beppu, Minako, Watanabe, Keisuke, Fujimaki, Yumi, Tsuji, Yukiko, Shimizu, Toshio, Mizuno, Toshiki, Nakagawa, Masanori, Sawaguchi, Kyoko, Hanaoka, Hideki, Kuwabara, Satoshi

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION 16 ( 5-6 ) 353 - 358 2015.08

Research paper (scientific journal), Joint Work,  ISSN  2167-8421

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Predictive Power of a Body Shape Index for Development of Diabetes, Hypertension, and Dyslipidemia in Japanese Adults: A Retrospective Cohort Study

Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

PLOS ONE 10 ( 6 ) 194 - 200 2015.06

Research paper (scientific journal), Joint Work,  ISSN  1932-6203

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A multi-institutional prospective observational study of SRS for patients with multiple brain metastases (BMs)

Yamamoto, Masaaki, Serizawa, Toru, Higuchi, Yoshinori, Sato, Yasunori, Kawagishi, Jun, Yamanaka, Kazuhiro, Shuto, Takashi, Akabane, Atsuya, Jokura, Hidefumi, Yomo, Shoji, Nagano, Osamu, Aoyama, Hidefumi

JOURNAL OF CLINICAL ONCOLOGY 33 ( 15 ) 1805 - 1810 2015.05

Research paper (international conference proceedings), Joint Work,  ISSN  0732-183X

Hidden osteophyte formation on plain X-ray is the predictive factor for development of knee osteoarthritis after 48 months - data from the Osteoarthritis Initiative

Katsuragi J., Sasho T., Yamaguchi S., Sato Y., Watanabe A., Akagi R., Muramatsu Y., Mukoyama S., Akatsu Y., Fukawa T., Endo J., Hoshi H., Yamamoto Y., Sasaki T., Takahashi K.

Osteoarthritis and Cartilage (Osteoarthritis and Cartilage)  23 ( 3 ) 383 - 390 2015.03

ISSN  10634584

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© 2014 Osteoarthritis Research Society International. Objective: To examine whether the detection of osteophytes anywhere in the knee could serve as a pre-radiographic biomarker for osteoarthritis (OA) development. Methods: Baseline magnetic resonance imaging (MRIs) of 132 participants in the Osteoarthritis Initiative (OAI) were studied. Based on radiographs, 66 knees were assessed as osteoarthritis-free (no-osteoarthritis [NOA], or Kellgren/Lawrence [K/L] severity grade 0/1 both at baseline and 48 months), and another 66 knees were assessed as having radiographic OA changes (pre-radiographic osteoarthritis [PROA], or with K/L grade 0/1at baseline and grade ≥2at 48 months). Using baseline MRI data, we examined eight sites of osteophyte formation: the medial and lateral femoral condyle (MFC and LFC, respectively); medial and lateral tibial plateau (MTP and LTP, respectively); medial and lateral facets of the patellofemoral joint (PM and PL, respectively); tibial spine (TS); and femoral intercondylar notch (IC). Knee joint osteophyte size was assessed via the 8-point marginal osteophytes item of the whole-organ magnetic resonance imaging score (WORMS). The frequencies and distributions of osteophytes were compared between groups. Results: Mild-size osteophytes (defined as score ≥2) were observed more frequently at the MFC (P=0.00278), MTP (P=0.0046), TS (P=0.0146), PM (P<0.0001), PL (P=0.0012), and IC (P<0.0001) in PROA knees than in NOA knees. Moderate-size osteophytes (defined as score ≥4) were more frequently observed in PROA knees than in NOA knees only at the IC (P<0.0001). Conclusion: Knees with osteophyte formation at the IC, even those of K/L severity grade 0/1, are at risk for the development of radiographic OA by 48 months.

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Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin compared with alpha-glucosidase inhibitor in Japanese patients with type 2 diabetes inadequately controlled on metformin or pioglitazone alone

Yokoh H, Kobayashi K, Sato Y, Takemoto M, Uchida D, Kanatuka A, Kuribayashi N, Terano T, Hashimoto N, Sakurai K, Hanaoka H, Ishikawa K, Onishi S, Yokote K, on behalf of the SUCCESS Study Group

JOURNAL OF DIABETES INVESTIGATION 6 ( 2 ) 182 - 191 2015.03

Research paper (scientific journal), Joint Work,  ISSN  2040-1116

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Current symptomatology in multiple sclerosis and neuromyelitis optica

Muto M., Mori M., Sato Y., Uzawa A., Masuda S., Uchida T., Kuwabara S.

European Journal of Neurology (European Journal of Neurology)  22 ( 2 ) 299 - 304 2015.02

ISSN  13515101

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© 2014 EAN. Background and objectives: Several symptoms and signs are characteristic of multiple sclerosis (MS) such as Lhermitte's sign, Uhthoff's phenomenon and painful tonic seizure. Neuromyelitis optica (NMO) is another inflammatory disease of the central nervous system, and most of the opticospinal form of MS is thought to be NMO. This study aimed to investigate the frequencies of symptoms and signs, previously regarded as characteristic of MS, in NMO and MS patients. Methods: Consecutive Japanese NMO-plus patients [NMO (n = 30) or partial NMO (n = 18)] and MS patients (n = 128) seen at Chiba University Hospital between 2011 and 2012 were investigated for the frequencies of symptoms and signs characteristic of MS. Logistic regression analyses were used to identify factors that distinguished NMO-plus from MS. Results: Univariate analyses revealed that tonic seizures, Lhermitte's sign, persistent pain, fatigue and girdle sensation were more frequent in NMO-plus patients than in MS patients. Multivariate logistic regression analysis showed that paroxysmal itching, Uhthoff's phenomenon, Lhermitte's sign and girdle sensation were more characteristic of NMO-plus than of MS. Conclusions: Several classical MS symptoms and signs are more frequent in NMO patients than MS patients, which may be caused by the differences in the severity of inflammation, and localization and extensiveness of demyelinated lesions.

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Efficacy of Peanut and Soybean-Specific IgE Probability Curves Derived from Two Different Serologic Methods (3g and immunoCAP)

Ogura, Kiyotake, Sato, Sakura, Kutsuwada, Kazuko, Sato, Yasunori, Ebisawa, Motohiro

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 135 ( 2 ) AB248 - AB248 2015.02

Research paper (international conference proceedings), Joint Work,  ISSN  0091-6749

Japanese POEMS syndrome with Thalidomide (J-POST) Trial: study protocol for a phase II/III multicentre, randomised, double-blind, placebo-controlled trial

Katayama K, Misawa S, Sato Y, Sobue G, Yabe I, Watanabe O, Nishizawa M, Kusunoki S, Kikuchi S, Nakashima I, Ikeda S, Kohara N, Kanda T, Kira J, Hanaoka H, Kuwabara S

BMJ OPEN 5 ( 1 ) 182 - 191 2015

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Validity assessment of self-reported medication use by comparing to pharmacy insurance claims

Fujita, Misuzu, Sato, Yasunori, Nagashima, Kengo, Takahashi, Sho, Hata, Akira

BMJ OPEN 5 ( 11 ) 307 - 312 2015

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial)

Aoyagi R, Hamada H, Sato Y, Suzuki H, Onouchi Y, Ebata R, Nagashima K, Terauchi M, Terai M, Hanaoka H, Hata A

BMJ OPEN 5 ( 12 ) 307 - 312 2015

Research paper (scientific journal), Joint Work,  ISSN  2044-6055

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Prognostic Factors for Surgically Resected N2 Non-small Cell Lung Cancer

Kawasaki, Keishi, Sato, Yasunori, Suzuki, Yoshio, Saito, Haruhisa, Nomura, Yukihiro, Yoshida, Yukihiro

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 21 ( 3 ) 217 - 222 2015

Research paper (scientific journal), Joint Work,  ISSN  1341-1098

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Worse Prognosis for Stage IA Lung Cancer Patients with Smoking History and More Severe Chronic Obstructive Pulmonary Disease

Yoshida, Yukihiro, Kage, Hidenori, Murakawa, Tomohiro, Sato, Yasunori, Ota, Satoshi, Fukayama, Masashi, Nakajima, Jun

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 21 ( 3 ) 194 - 200 2015

Research paper (scientific journal), Joint Work,  ISSN  1341-1098

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Vascular endothelial growth factor as a predictive marker for POEMS syndrome treatment response: Retrospective cohort study

Misawa S., Sato Y., Katayama K., Hanaoka H., Sawai S., Beppu M., Nomura F., Shibuya K., Sekiguchi Y., Iwai Y., Watanabe K., Amino H., Ohwada C., Takeuchi M., Sakaida E., Nakaseko C., Kuwabara S.

BMJ Open (BMJ Open)  5 ( 11 )  2015

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Objective: POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterised by plasma cell dyscrasia and overproduction of vascular endothelial growth factor (VEGF). VEGF is assumed to be useful in monitoring disease activity, because VEGF levels usually decrease after treatment. However, there is no study to investigate whether the extent of decrease in VEGF correlates with clinical outcome. We tested the predictive efficacy of serum VEGF levels in POEMS syndrome. Method: This was an institutional review board approved retrospective observational cohort study of 20 patients with POEMS monitored regularly for more than 12 months (median follow-up, 87 months) after treatment onset using our prospectively accumulated database of POEMS from 1999 to 2015. Patients were treated by autologous peripheral blood stem cell transplantation or thalidomide administration. Serum VEGF was measured by ELISA. Outcome measures included clinical and laboratory findings and relapsefree survival. Results: Serum VEGF levels decreased rapidly after treatment, and stabilised by 6 months post treatment. Patients with normalised serum VEGF levels (<1040 pg/mL) at 6 months showed prolonged relapsefree survival (HR=12.81, 95% CI 2.691 to 90.96; p=0.0001) and greater later clinical improvement. The rate of serum VEGF reduction over the first 6 months post treatment correlated with increased grip strength, serum albumin levels, and compound muscle action potential amplitudes at 12 months. Conclusions: Serum VEGF level at 6 months post treatment is a predicative biomarker for disease activity and prognosis in POEMS syndrome. Serum VEGF could be used as a surrogate endpoint for relapse-free survival or clinical or laboratory improvement of POEMS syndrome for clinical trials.

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