論文 - 岡野　栄之

Role of HIF-1 alpha-activated Epac1 on HSC-mediated neuroplasticity in stroke model

岡野 栄之

NEUROBIOLOGY OF DISEASE 58   76 - 91 2013年10月

研究論文（学術雑誌）,  ISSN  0969-9961

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Differential cellular localization of antioxidant enzymes in the trigeminal ganglion

Sato H., Shibata M., Shimizu T., Shibata S., Toriumi H., Ebine T., Kuroi T., Iwashita T., Funakubo M., Kayama Y., Akazawa C., Wajima K., Nakagawa T., Okano H., Suzuki N.

Neuroscience 248   345 - 358 2013年09月

ISSN  0306-4522

　概要を見る

<p>Because of its high oxygen demands, neural tissue is predisposed to oxidative stress. Here, our aim was to clarify the cellular localization of antioxidant enzymes in the trigeminal ganglion. We found that the transcriptional factor Sox10 is localized exclusively in satellite glial cells (SGCs) in the adult trigeminal ganglion. The use of transgenic mice that express the fluorescent protein Venus under the Sox10 promoter enabled us to distinguish between neurons and SGCs. Although both superoxide dismutases 1 and 2 were present in the neurons, only superoxide dismutase 1 was identified in SGCs. The enzymes relevant to hydrogen peroxide degradation displayed differential cellular localization, such that neurons were endowed with glutathione peroxidase 1 and thioredoxin 2, and catalase and thioredoxin 2 were present in SGCs. Our immunohistochemical finding showed that only SGCs were labeled by the oxidative damage marker 8-hydroxy-2'-deoxyguanosine, which indicates that the antioxidant systems of SGCs were less potent. The transient receptor potential vanilloid subfamily member 1 (TRPV1), the capsaicin receptor, is implicated in inflammatory hyperalgesia, and we demonstrated that topical capsaicin application causes short-lasting mechanical hyperalgesia in the face. Our cell-based assay revealed that TRPV1 agonist stimulation in the presence of TRPV1 overexpression caused reactive oxygen species-mediated caspase-3 activation. Moreover, capsaicin induced the cellular demise of primary TRPV1-positive trigeminal ganglion neurons in a dose-dependent manner, and this effect was inhibited by a free radical scavenger and a pancaspase inhibitor. This study delineates the localization of antioxidative stress-related enzymes in the trigeminal ganglion and reveals the importance of the pivotal role of reactive oxygen species in the TRPV1-mediated caspase-dependent cell death of trigeminal ganglion neurons. Therapeutic measures for antioxidative stress should be taken to prevent damage to trigeminal primary sensory neurons in inflammatory pain disorders. © 2013 IBRO.</p>

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[110th Scientific Meeting of the Japanese Society of Internal Medicine

Nakamura Masaya, Okano Hideyuki, Toyama Yoshiaki

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 102 （ 9 ） 2247 - 2253 2013年09月

ISSN  0021-5384

The effect of SCN1A mutations on patient-derived GABAergic neurons

Higurashi Norimichi, Okano Hideyuki, Hirose Shinichi

Future Neurology 8 （ 5 ） 487 - 489 2013年09月

ISSN  1479-6708

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Sox6 Up-Regulation by Macrophage Migration Inhibitory Factor Promotes Survival and Maintenance of Mouse Neural Stem/Progenitor Cells

岡野 栄之

PLOS ONE 8 （ 9 ） 279 - 284 2013年09月

研究論文（学術雑誌）,  ISSN  1932-6203

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Sema3A regulates bone-mass accrual through sensory innervations (vol 497, pg 490, 2013)

岡野 栄之

NATURE 500 （ 7464 ） 855 - 864 2013年08月

研究論文（学術雑誌）,  ISSN  0028-0836

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SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis

岡野 栄之

MODERN PATHOLOGY 26 （ 8 ） 1041 - 1050 2013年08月

研究論文（学術雑誌）,  ISSN  0893-3952

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LNGFR(+)THY-1(+)VCAM-1(hi+) Cells Reveal Functionally Distinct Subpopulations in Mesenchymal Stem Cells

岡野 栄之

STEM CELL REPORTS 1 （ 2 ） 152 - 165 2013年08月

研究論文（学術雑誌）,  ISSN  2213-6711

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The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

岡野 栄之

MOLECULAR BRAIN 6   13064 - 13069 2013年07月

研究論文（学術雑誌）,  ISSN  1756-6606

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Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma

岡野 栄之

CANCER RESEARCH 73 （ 14 ） 4559 - 4570 2013年07月

研究論文（学術雑誌）,  ISSN  0008-5472

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Development and Characterization of cDNA Resources for the Common Marmoset: One of the Experimental Primate Models

岡野 栄之

DNA RESEARCH 20 （ 3 ） 255 - 262 2013年06月

研究論文（学術雑誌）,  ISSN  1340-2838

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Kidney Specific Protein-Positive Cells Derived from Embryonic Stem Cells Reproduce Tubular Structures In Vitro and Differentiate into Renal Tubular Cells

岡野 栄之

PLOS ONE 8 （ 6 ） 811 - 821 2013年06月

研究論文（学術雑誌）,  ISSN  1932-6203

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Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo

岡野 栄之

JOURNAL OF INVESTIGATIVE DERMATOLOGY 133 （ 6 ） 1479 - 1488 2013年06月

研究論文（学術雑誌）,  ISSN  0022-202X

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Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer

岡野 栄之

ONCOTARGET 4 （ 5 ） 739 - 750 2013年05月

研究論文（学術雑誌）,  ISSN  1949-2553

The Drosophila Ortholog of MLL3 and MLL4, trithorax related, Functions as a Negative Regulator of Tissue Growth

岡野 栄之

MOLECULAR AND CELLULAR BIOLOGY 33 （ 9 ） 1702 - 1710 2013年05月

研究論文（学術雑誌）,  ISSN  0270-7306

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A human Dravet syndrome model from patient induced pluripotent stem cells

岡野 栄之

MOLECULAR BRAIN 6   1312 - 1313 2013年05月

研究論文（学術雑誌）,  ISSN  1756-6606

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Correction

Muto Jun, Imai Takao, Ogawa Daisuke, Nishimoto Yoshinori, Okada Yohei, Mabuchi Yo, Kawase Takeshi, Iwanami Akio, Mischel Paul S., Saya Hideyuki, Yoshida Kazunari, Matsuzaki Yumi, Okano Hideyuki

PLoS ONE 8 （ 4 ）  2013年04月

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Diffusion tensor imaging and tractography of the spinal cord: From experimental studies to clinical application

岡野 栄之

EXPERIMENTAL NEUROLOGY 242   74 - 82 2013年04月

研究論文（学術雑誌）,  ISSN  0014-4886

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Modulation of the shape and speed of a chemical wave in an unstirred Belousov-Zhabotinsky reaction by a rotating magnet

岡野 栄之

BIOELECTROMAGNETICS 34 （ 3 ） 220 - 230 2013年04月

研究論文（学術雑誌）,  ISSN  0197-8462

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Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma (vol 77, pg 58, 2013)

岡野 栄之

NEURON 78 （ 2 ） 403 - 403 2013年04月

研究論文（学術雑誌）,  ISSN  0896-6273

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