論文 - 岡野　栄之

Renin-angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction

Kurihara Toshihide, Ozawa Yoko, Ishida Susumu, Okano Hideyuki, Tsubota Kazuo

International Journal of Inflammation 2012 2012年

ISSN  2090-8040

　概要を見る

<p>The renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator. In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond more dynamically to systemic or local cues. While RAS is important for controlling normal inflammatory responses, hyperactivation of the pathway can cause neural dysfunction by inducing accelerated degradation of some neuronal proteins such as synaptophysin and by activating pathological glial responses. Chronic inflammation and oxidative stress are risk factors for high incidence vision-threatening diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. In fact, increasing evidence suggests that RAS inhibition may actually prevent progression of various ocular diseases including uveitis, DR, AMD, and glaucoma. Therefore, RAS inhibition may be a promising therapeutic approach to fine-tune inflammatory responses and to prevent or treat certain ocular and neurodegenerative diseases. © 2012 Toshihide Kurihara et al.</p>

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Nestin Protein Is Phosphorylated in Adult Neural Stem/Progenitor Cells and Not Endothelial Progenitor Cells

岡野 栄之

STEM CELLS INTERNATIONAL    1410 - 1422 2012年

研究論文（学術雑誌）,  ISSN  1687-966X

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Role of adrenergic receptors in the neural differentiation from pluripotent stem cells

岡野 栄之

JOURNAL OF PHARMACOLOGICAL SCIENCES 118   172P - 172P 2012年

研究論文（学術雑誌）,  ISSN  1347-8613

Cisterna-specific Localization of Glycosylation-related Proteins to the Golgi Apparatus

岡野 栄之

CELL STRUCTURE AND FUNCTION 37 （ 1 ） 55 - 63 2012年

研究論文（学術雑誌）,  ISSN  0386-7196

Control mechanism of gefitinib-resistant human non-small-cell lung cancer (NSCLC) cells growth and transformation by stimulation of delta-opioid receptors

岡野 栄之

JOURNAL OF PHARMACOLOGICAL SCIENCES 118   123P - 123P 2012年

研究論文（学術雑誌）,  ISSN  1347-8613

The analysis of telomeric status in "Extraordinary Cancer Resistant Mammal" Naked mole rat

岡野 栄之

JOURNAL OF PHARMACOLOGICAL SCIENCES 118   175P - 175P 2012年

研究論文（学術雑誌）,  ISSN  1347-8613

Regeneration of the damaged CNS using human iPSCs-derived neural progenitor cells

岡野 栄之

JOURNAL OF PHARMACOLOGICAL SCIENCES 118   48P - 48P 2012年

研究論文（学術雑誌）,  ISSN  1347-8613

MicroRNAs in neural stem cells and neurogenesis

岡野 栄之

FRONTIERS IN NEUROSCIENCE 6   S347 - S348 2012年

研究論文（学術雑誌）,  ISSN  1662-453X

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NOTCH SIGNALING AND THE DEVELOPING INNER EAR

岡野 栄之

NOTCH SIGNALING IN EMBRYOLOGY AND CANCER 727   161 - 173 2012年

研究論文（学術雑誌）,  ISSN  0065-2598

Usefulness of human disease-specific iPS cells research for understanding of age-related higher brain dysfunction

岡野 栄之

JOURNAL OF PHARMACOLOGICAL SCIENCES 118   124P - 124P 2012年

研究論文（学術雑誌）,  ISSN  1347-8613

Nestin Protein Is Phosphorylated in Adult Neural Stem/Progenitor Cells and Not Endothelial Progenitor Cells

岡野 栄之

STEM CELLS INTERNATIONAL    1410 - 1422 2012年

研究論文（学術雑誌）,  ISSN  1687-966X

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Novel Method for Analyzing Locomotor Ability after Spinal Cord Injury in Rats: Technical Note

岡野 栄之

NEUROLOGIA MEDICO-CHIRURGICA 53 （ 12 ） 907 - 913 2013年12月

研究論文（学術雑誌）,  ISSN  0470-8105

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Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: Utility and limitation of the surrogate tissues in research for brain disorders

岡野 栄之

NEUROSCIENCE RESEARCH 77 （ 4 ） 247 - 250 2013年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Multidimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)

岡野 栄之

FRONTIERS IN NEUROANATOMY 7   2462 - 2469 2013年12月

研究論文（学術雑誌）,  ISSN  1662-5129

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In vivo tracing of neural tracts in tiptoe-walking yoshimura mice by diffusion tensor tractography

Takano Morito, Komaki Yuji, Hikishima Keigo, Konomi Tsunehiko, Fujiyoshi Kanehiro, Tsuji Osahiko, Okano Hideyuki, Toyama Yoshiaki, Nakamura Masaya

  107 - 117 2013年11月

　概要を見る

<p>In ossification of the posterior longitudinal ligaments (OPLL), axonal disruption results in motor and sensory function impairment. Twy (tiptoe-walking Yoshimura) mice develop spontaneous calcification in the cervical ligaments, thereby causing chronic compression of the spinal cords. To determine whether in vivo diffusion tensor tractography (DTT) can evaluate the axonal disruption of the chronic compressive spinal cords in twy mice, 6-, 15-, and 20-week-old twy mice were chronologically subjected to DTT. MRI was performed using a 7.0-Tesla magnet with a surface coil (CryoProbe). Diffusion tensor images were analyzed using TrackVis (Massachusetts General Hospital, MA, USA). We succeeded in depicting in vivo high-resolution DTT of the twy mice. The progress of the ligamentous calcification was observed at C2-3 level in each twy mouse, and the number of RT-97 or SMI31 positive fibers was decreased depending on the severity of the compression of the spinal cord. Quantitative analysis of sequential DTT enabled to detect subtle damage of the compressed spinal cord prior to the deterioration of neurological function in twy mice. Thus, in a clinical setting, DTT could be a new effective imaging modality in patients with cervical OPLL.</p>

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Regenerative medicine for spinal cord injury utilizing iPS cells

Tsuji Osahiko, Nori Satoshi, Kobayashi Yoshiomi, Fujiyoshi Kanehiro, Okano Hideyuki, Toyama Yoshiaki, Nakamura Masaya

  229 - 245 2013年11月

　概要を見る

<p>Reports of functional recovery from spinal cord injury (SCI) after the transplantation of rat-fetus-derived neural stem/precursor cells (NS/PCs) and murine embryonic stem cells (ES cells) have raised great expectations for the successful clinical trial of stem cell transplantation therapy. However, the ethical issues concerning about destroying human embryos or fertilized oocytes to obtain such stem cells have been a major impediment to developing clinically useful stem cell sources and to use them in clinical applications. Recently, induced pluripotent stem cells (iPS cells), which can serve as a source of autologous cell transplantation, have been attracting a lot of attention as a clinically practical alternative to stem cells obtained directly from tissues. In this chapter, we outline the neural induction of murine and human iPS cells, their therapeutic efficacy in mouse and primate SCI models, and their safety in vivo.</p>

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Recombinant human hepatocyte growth factor promotes functional recovery after spinal cord injury

Kitamura Kazuya, Iwanami Akio, Fujiyoshi Kanehiro, Yamane Jun Ichi, Hikishima Keigo, Funakoshi Hiroshi, Nakamura Toshikazu, Aoki Masashi, Toyama Yoshiaki, Okano Hideyuki, Nakamura Masaya

  147 - 167 2013年11月

　概要を見る

<p>Hepatocyte growth factor (HGF), which is a potent mitogen for mature hepatocytes and a mediator of the inflammatory responses to tissue injury, was recently highlighted as a potent neurotrophic factor in the central nervous system. We revealed that introducing exogenous HGF into the injured rat spinal cord using a herpes simplex virus-1 vector significantly reduces the area of damaged tissue and promotes functional recovery. However, this rat study did not examine the therapeutic effects of administering HGF after injury, which is the most critical issue for clinical application. To translate this strategy to human treatment, we induced a contusive cervical SCI in the common marmoset, a primate, and then administered recombinant human HGF (rhHGF) intrathecally. Motor function was assessed using an original open-field scoring system focusing on manual function, including reach-and-grasp performance and hand placement in walking. The intrathecal rhHGF preserved the corticospinal fibers and myelinated areas, thereby promoting functional recovery. This study demonstrates the therapeutic effects, safety, and clinical efficacy of intrathecal rhHGF treatment for SCI in adult nonhuman primates and the possibility that this novel therapy may be suitable for clinical application.</p>

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Assessment of injured spinal cord using diffusion tensor tractography

Fujiyoshi Kanehiro, Konomi Tsunehiko, Tsuji Osahiko, Yamada Masayuki, Hikishima Keigo, Momoshima Suketaka, Okano Hideyuki, Toyama Yoshiaki, Nakamura Masaya

  345 - 365 2013年11月

　概要を見る

<p>In spinal cord injury (SCI), the evaluation of axonal fibers is important to assess the severity of injury and efficacy of any treatment protocol, but conventional methods such as tracer injection in the brain parenchyma are highly invasive and require histological evaluation, precluding clinical applications. Magnetic resonance imaging (MRI) is essential for predicting prognosis and planning treatment of patients with SCI noninvasively. However, the information provided by conventional T1- and T2-weighted MRI of the spinal cord is essentially limited to the differentiation of the white matter from the gray matter. By contrast, diffusion-weighted magnetic resonance imaging (DWI) provides much information about biological structures. In particular, diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are powerful tools for evaluating white matter fibers in the central nervous system. We previously established a reproducible SCI model in adult common marmosets and demonstrated that DTT could be used to trace the neural tracts in the intact and injured spinal cord of these animals in vivo. Recently, many reports using DTT to analyze the spinal cord area have been published. Based on the findings from our experimental studies, we are now routinely performing DTT of the human spinal cord clinically. In this chapter, we outline the basic principles of DTT and describe the characteristics, limitations, and clinical application of DTT in the spinal cord.</p>

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Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

岡野 栄之

NATURE COMMUNICATIONS 4   106 - 114 2013年11月

研究論文（学術雑誌）,  ISSN  2041-1723

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A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis

岡野 栄之

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 132 （ 5 ） 1111 - + 2013年11月

研究論文（学術雑誌）,  ISSN  0091-6749

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