論文 - 岡野　栄之

Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage

岡野 栄之

NEUROSCIENCE RESEARCH 61   S231 - S231 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Analysis of a transcription factor involved in neural stem cell maintenance

岡野 栄之

NEUROSCIENCE RESEARCH 61   S230 - S230 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Sox21 is required for adult neurogenesis in mouse hippocampus

岡野 栄之

NEUROSCIENCE RESEARCH 61   S96 - S96 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Whole genome transcriptome profile of human embryonic stem cells and differentiated cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S43 - S43 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Coordination between the nestin gene expression and the morphological alteration of cortical neural progenitor cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S87 - S87 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Prospective isolation of living neural stem cells from mouse brain through surface N-glycan

岡野 栄之

NEUROSCIENCE RESEARCH 61   S139 - S139 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

In vivo imaging of contusive spinal cord injury using diffusion tensor tractography in Non-human Primates

岡野 栄之

NEUROSCIENCE RESEARCH 61   S64 - S64 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Kspot, a novel ubiquitin ligase, regulates synaptic activity

岡野 栄之

NEUROSCIENCE RESEARCH 61   S218 - S218 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Altered participation in neural differentiation by HuD splice variants

岡野 栄之

NEUROSCIENCE RESEARCH 61   S229 - S229 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Comparison between ES cell-derived neurogenic and gliogenic neurospheres as a source of transplantation for spinal cord injury

岡野 栄之

NEUROSCIENCE RESEARCH 61   S43 - S43 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Young neurons migrate along the blood vessel scaffold in the regenerating postnatal brain

岡野 栄之

NEUROSCIENCE RESEARCH 61   S58 - S58 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells

岡野 栄之

STEM CELLS 26 （ 12 ） 3086 - 3098 2008年

研究論文（学術雑誌）,  ISSN  1066-5099

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A factor secreted from bone-marrow-derived endothelial progenitor cells promotes self-renewal of neural stem cells in mice

岡野 栄之

NEUROSCIENCE RESEARCH 61   S86 - S86 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Application of q-space MRI to spinal cord in common marmoset

岡野 栄之

NEUROSCIENCE RESEARCH 61   S277 - S277 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

A novel gamma-secretase inhibitor, LY411575, replaced auditory hair cells and recovered hearing loss after severe acoustic trauma in mice

岡野 栄之

NEUROSCIENCE RESEARCH 61   S25 - S25 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Notch-Hes1 Pathway Contributes to the Cochlear Prosensory Formation Potentially Through the Transcriptional Down-Regulation of p27(Kip1)

岡野 栄之

JOURNAL OF NEUROSCIENCE RESEARCH 87 （ 16 ） 3521 - 3534 2009年12月

研究論文（学術雑誌）,  ISSN  0360-4012

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Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus)

岡野 栄之

CLONING AND STEM CELLS 11 （ 4 ） 575 - 583 2009年12月

研究論文（学術雑誌）,  ISSN  1536-2302

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Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset

岡野 栄之

NEUROSCIENCE RESEARCH 65 （ 4 ） 384 - 392 2009年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Neuronal re-juvenilization in the nucleus ambiguus after vagal nerve injury

岡野 栄之

NEUROSCIENCE RESEARCH 65 （ 4 ） 353 - 359 2009年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice

Hashimoto H., Arai T., Mori A., Kawai K., Hikishima K., Ohnishi Y., Eto T., Ito M., Hioki K., Suzuki R., Ohsugi M., Saito M., Ueyama Y., Okano H., Yamauchi T., Kubota N., Ueki K., Tobe K., Tamaoki N., Kadowaki T., Kosaka K.

Experimental and Clinical Endocrinology and Diabetes 117 （ 10 ） 577 - 586 2009年11月

ISSN  0947-7349

　概要を見る

<p>Current Japanese and American diets and Japanese diet immediately after the War were converted to laboratory animal diets. As a result, current laboratory animal diet (CA-I, CLEA) unexpectedly resembled the diet of Japanese after the War. This is considered to result in an under-evaluation of diabetes research using laboratory animals at present. Therefore, changes in insulin signals caused by current Japanese and American diets were examined using IRS-2 deficient mice (Irs2 ^-/- mice) and mechanisms of aggravation of type 2 diabetes due to modern diets were examined. Irs2 ^-/- mice at 6 weeks of age were divided into three groups: Japanese diet (Jd) group, American diet (Ad) group and CA-I diet [regular diet (Rd)] group. Each diet was given to the dams from 7 days before delivery. When the Irs2 ^-/- mice reached 6 weeks of age, the glucose tolerance test (GTT), insulin tolerance test (ITT) and organ sampling were performed. The sampled organs and white adipose tissue were used for analysis of RNA, enzyme activity and tissues. In GTT and ITT, the Ad group showed worse glucose tolerance and insulin resistance than the Rd group. Impaired glucose tolerance of the Jd group was the same as that of the Rd group, but insulin resistance was worse than in the Rd group. These results were caused an increase in fat accumulation and adipocytes in the peritoneal cavity by lipogenic enzyme activity in the liver and muscle, and the increase in TNFa of hypertrophic adipocyte origin further aggravated insulin resistance and the increase in resistin also aggravated the impaired glucose tolerance, leading to aggravation of type 2 diabetes. The Japanese and American diets given to the Irs2 ^-/- mice, which we developed, showed abnormal findings in some Irs2 ^-/- mice but inhibited excessive reactions of insulin signals as diets used in ordinary nutritional management.</p>

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