論文 - 岡野　栄之

Isolation and identification of mesenchymal stem cells in human bone marrow

岡野 栄之

NEUROSCIENCE RESEARCH 61   S84 - S84 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Mechanism of axonal regeneration and degeneration in spinal cord injury and other CNS diseases

岡野 栄之

NEUROSCIENCE RESEARCH 61   S8 - S8 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Analysis of inner ear-selective cis-regulatory enhancer of Sox21 gene

岡野 栄之

NEUROSCIENCE RESEARCH 61   S103 - S103 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

The morphological maturation course of the cerebellar Purkinje cell generated from the mouse embryonic stem cell

岡野 栄之

NEUROSCIENCE RESEARCH 61   S158 - S158 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

A practical device for pinpoint delivery of molecules into multiple neurons in culture

岡野 栄之

NEUROSCIENCE RESEARCH 61   S211 - S211 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Directed neural differentiation of induced pluripotent stem cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S44 - S44 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Switching mechanism to neural differentiation controlled by Musashi and Hu proteins.

岡野 栄之

NEUROSCIENCE RESEARCH 61   S155 - S155 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Effects of granulocyte macrophage colony stimulating factor following spinal cord injury in mice

岡野 栄之

NEUROSCIENCE RESEARCH 61   S237 - S237 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Hepatocyte growth factor (HGF) promotes endogenous repair and functional recovery after spinal cord injury: Preclinical trial from rodent to primate

岡野 栄之

NEUROSCIENCE RESEARCH 61   S16 - S16 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Self-assembling peptide scaffold promotes the axonal growth in the injured spinal cord

岡野 栄之

NEUROSCIENCE RESEARCH 61   S93 - S93 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage

岡野 栄之

NEUROSCIENCE RESEARCH 61   S231 - S231 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Analysis of a transcription factor involved in neural stem cell maintenance

岡野 栄之

NEUROSCIENCE RESEARCH 61   S230 - S230 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Sox21 is required for adult neurogenesis in mouse hippocampus

岡野 栄之

NEUROSCIENCE RESEARCH 61   S96 - S96 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Whole genome transcriptome profile of human embryonic stem cells and differentiated cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S43 - S43 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Coordination between the nestin gene expression and the morphological alteration of cortical neural progenitor cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S87 - S87 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Notch-Hes1 Pathway Contributes to the Cochlear Prosensory Formation Potentially Through the Transcriptional Down-Regulation of p27(Kip1)

岡野 栄之

JOURNAL OF NEUROSCIENCE RESEARCH 87 （ 16 ） 3521 - 3534 2009年12月

研究論文（学術雑誌）,  ISSN  0360-4012

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Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus)

岡野 栄之

CLONING AND STEM CELLS 11 （ 4 ） 575 - 583 2009年12月

研究論文（学術雑誌）,  ISSN  1536-2302

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Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset

岡野 栄之

NEUROSCIENCE RESEARCH 65 （ 4 ） 384 - 392 2009年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Neuronal re-juvenilization in the nucleus ambiguus after vagal nerve injury

岡野 栄之

NEUROSCIENCE RESEARCH 65 （ 4 ） 353 - 359 2009年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice

Hashimoto H., Arai T., Mori A., Kawai K., Hikishima K., Ohnishi Y., Eto T., Ito M., Hioki K., Suzuki R., Ohsugi M., Saito M., Ueyama Y., Okano H., Yamauchi T., Kubota N., Ueki K., Tobe K., Tamaoki N., Kadowaki T., Kosaka K.

Experimental and Clinical Endocrinology and Diabetes 117 （ 10 ） 577 - 586 2009年11月

ISSN  0947-7349

　概要を見る

<p>Current Japanese and American diets and Japanese diet immediately after the War were converted to laboratory animal diets. As a result, current laboratory animal diet (CA-I, CLEA) unexpectedly resembled the diet of Japanese after the War. This is considered to result in an under-evaluation of diabetes research using laboratory animals at present. Therefore, changes in insulin signals caused by current Japanese and American diets were examined using IRS-2 deficient mice (Irs2 ^-/- mice) and mechanisms of aggravation of type 2 diabetes due to modern diets were examined. Irs2 ^-/- mice at 6 weeks of age were divided into three groups: Japanese diet (Jd) group, American diet (Ad) group and CA-I diet [regular diet (Rd)] group. Each diet was given to the dams from 7 days before delivery. When the Irs2 ^-/- mice reached 6 weeks of age, the glucose tolerance test (GTT), insulin tolerance test (ITT) and organ sampling were performed. The sampled organs and white adipose tissue were used for analysis of RNA, enzyme activity and tissues. In GTT and ITT, the Ad group showed worse glucose tolerance and insulin resistance than the Rd group. Impaired glucose tolerance of the Jd group was the same as that of the Rd group, but insulin resistance was worse than in the Rd group. These results were caused an increase in fat accumulation and adipocytes in the peritoneal cavity by lipogenic enzyme activity in the liver and muscle, and the increase in TNFa of hypertrophic adipocyte origin further aggravated insulin resistance and the increase in resistin also aggravated the impaired glucose tolerance, leading to aggravation of type 2 diabetes. The Japanese and American diets given to the Irs2 ^-/- mice, which we developed, showed abnormal findings in some Irs2 ^-/- mice but inhibited excessive reactions of insulin signals as diets used in ordinary nutritional management.</p>

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