論文 - 岡野　栄之

Neuroepithelial stem cells are converted into neural progenitors during an elongated interphase in Drosophila larval optic lobe

岡野 栄之

NEUROSCIENCE RESEARCH 61   S156 - S156 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Mechanisms of reactive astrocytes migration after spina cord injury

岡野 栄之

NEUROSCIENCE RESEARCH 61   S227 - S227 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Intraarterial transplantation of mononuclear cells promotes neovascularization after transient cerebral ischemia in mice

岡野 栄之

NEUROSCIENCE RESEARCH 61   S134 - S134 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

An efficient screening method using inner-ear-derived spheres for selection of compounds that induce hair cell differentiation

岡野 栄之

NEUROSCIENCE RESEARCH 61   S57 - S57 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Cell therapy for spinal cord injury by neural stem/progenitor cells derived from induced pluripotent stem cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S69 - S69 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

The long-term live monitoring of transplanted human fetal neural stem/progenitor cells in vivo

岡野 栄之

NEUROSCIENCE RESEARCH 61   S85 - S85 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Post-translational regulation of Musashi1 RNA-binding activity and its translational control

岡野 栄之

NEUROSCIENCE RESEARCH 61   S154 - S154 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Isolation and characterization of neural crest-derived stem cells in mouse bone marrow

岡野 栄之

NEUROSCIENCE RESEARCH 61   S36 - S36 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Expression and function of Galectin-1 in adult neurogenesis of the hippocampus

岡野 栄之

NEUROSCIENCE RESEARCH 61   S239 - S239 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Visualization of neurogenesis with fluorescent proteins

岡野 栄之

NEUROSCIENCE RESEARCH 61   S229 - S229 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Common marmoset (Callithrix jacchus) as a model system to study neuroscience

岡野 栄之

NEUROSCIENCE RESEARCH 61   S14 - S14 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Effect of low oxygen environment on cultured human fetal neural stem/progenitor cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S157 - S157 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Prospective isolation and functional elucidation of murine mesenchymal stem cells

岡野 栄之

NEUROSCIENCE RESEARCH 61   S154 - S154 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Spinal cord injury: Emerging beneficial role of reactive astrocytes' migration

岡野 栄之

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 40 （ 9 ） 1649 - 1653 2008年

研究論文（学術雑誌）,  ISSN  1357-2725

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Multipotent neural crest-derived stem cells in the adult mouse cornea

岡野 栄之

NEUROSCIENCE RESEARCH 61   S281 - S281 2008年

研究論文（学術雑誌）,  ISSN  0168-0102

Notch-Hes1 Pathway Contributes to the Cochlear Prosensory Formation Potentially Through the Transcriptional Down-Regulation of p27(Kip1)

岡野 栄之

JOURNAL OF NEUROSCIENCE RESEARCH 87 （ 16 ） 3521 - 3534 2009年12月

研究論文（学術雑誌）,  ISSN  0360-4012

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Preimplantation Development of Somatic Cell Cloned Embryos in the Common Marmoset (Callithrix jacchus)

岡野 栄之

CLONING AND STEM CELLS 11 （ 4 ） 575 - 583 2009年12月

研究論文（学術雑誌）,  ISSN  1536-2302

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Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset

岡野 栄之

NEUROSCIENCE RESEARCH 65 （ 4 ） 384 - 392 2009年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Neuronal re-juvenilization in the nucleus ambiguus after vagal nerve injury

岡野 栄之

NEUROSCIENCE RESEARCH 65 （ 4 ） 353 - 359 2009年12月

研究論文（学術雑誌）,  ISSN  0168-0102

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Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice

Hashimoto H., Arai T., Mori A., Kawai K., Hikishima K., Ohnishi Y., Eto T., Ito M., Hioki K., Suzuki R., Ohsugi M., Saito M., Ueyama Y., Okano H., Yamauchi T., Kubota N., Ueki K., Tobe K., Tamaoki N., Kadowaki T., Kosaka K.

Experimental and Clinical Endocrinology and Diabetes 117 （ 10 ） 577 - 586 2009年11月

ISSN  0947-7349

　概要を見る

<p>Current Japanese and American diets and Japanese diet immediately after the War were converted to laboratory animal diets. As a result, current laboratory animal diet (CA-I, CLEA) unexpectedly resembled the diet of Japanese after the War. This is considered to result in an under-evaluation of diabetes research using laboratory animals at present. Therefore, changes in insulin signals caused by current Japanese and American diets were examined using IRS-2 deficient mice (Irs2 ^-/- mice) and mechanisms of aggravation of type 2 diabetes due to modern diets were examined. Irs2 ^-/- mice at 6 weeks of age were divided into three groups: Japanese diet (Jd) group, American diet (Ad) group and CA-I diet [regular diet (Rd)] group. Each diet was given to the dams from 7 days before delivery. When the Irs2 ^-/- mice reached 6 weeks of age, the glucose tolerance test (GTT), insulin tolerance test (ITT) and organ sampling were performed. The sampled organs and white adipose tissue were used for analysis of RNA, enzyme activity and tissues. In GTT and ITT, the Ad group showed worse glucose tolerance and insulin resistance than the Rd group. Impaired glucose tolerance of the Jd group was the same as that of the Rd group, but insulin resistance was worse than in the Rd group. These results were caused an increase in fat accumulation and adipocytes in the peritoneal cavity by lipogenic enzyme activity in the liver and muscle, and the increase in TNFa of hypertrophic adipocyte origin further aggravated insulin resistance and the increase in resistin also aggravated the impaired glucose tolerance, leading to aggravation of type 2 diabetes. The Japanese and American diets given to the Irs2 ^-/- mice, which we developed, showed abnormal findings in some Irs2 ^-/- mice but inhibited excessive reactions of insulin signals as diets used in ordinary nutritional management.</p>

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