研究者詳細 - 橋口　明典

論文 - 橋口　明典

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腎生検所見から何を学ぶか(No.57)　全身性浮腫で発症し血小板減少を伴った管内増殖性腎炎の1例

野田, 翔子, 住田, 圭一, 関根, 章成, 上野, 智敏, 今福, 礼, 川田, 真宏, 平松, 里佳子, 早見, 典子, 長谷川, 詠子, 諏訪部, 達也, 星野, 純一, 澤, 直樹, 高市, 憲明, 西田, 彩, 藤井, 晶子, 大橋, 健一, 藤井, 丈士, 乳原, 善文 and 橋口, 明典

腎と透析 79 （ 6 ） 984 - 996 2015年12月

共著, ISSN 0385-2156

Feature analyses of trabecular pattern of hepatocellular carcinoma using graph structure

Hideki Komagata, Masahiro Ishikawa, Naoki Kobayashi, Kazuma Shinoda, Masahiro Yamaguchi, Tokiya Abe, Akinori Hashiguchi, Michiie Sakamoto

IIEEJ Transactions on Image Electronics and Visual Computing （The Institute of Image Electronics Engineers of Japan） 3 （ 2 ） 80 - 91 2015年12月

共著, 査読有り, ISSN 2188-191X

CiNii Research

A case of severe osteomalacia caused by Tubulointerstitial nephritis with Fanconi syndrome in asymptomotic primary biliary cirrhosis

Yamaguchi, S, Maruyama, T, Wakino, S, Tokuyama, H, Hashiguchi, A, Tada, S, Homma, K, Monkawa, T, Thomas, J, Miyashita, K, Kurihara, I, Yoshida, T, Konishi, K, Hayashi, K, Hayashi, M, Itoh, H

BMC Nephrol 16 187 - 187 2015年11月

共著, ISSN 1471-2369

BACKGROUND: Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease, characterized by increased concentrations of serum IgM and the presence of circulating anti-mitochondrial antibodies. Although bone diseases such as osteoporosis or osteodystrophy are commonly associated with PBC, osteomalacia which is caused by abnormal vitamin D metabolism, mineralization defects, and phosphate deficiency has not been recognized as a complication of PBC. CASE PRESENTATION: We report the case of a 49-year-old Japanese woman who complained of multiple fractures. Hypophosphatemic osteomalacia was diagnosed from a low serum phosphorus level, 1,25-dihydroxyvitamin D3 level, high levels of bone specific alkaline phosphatase and the findings of bone scintigraphy, although a bone biopsy was not performed. Twenty four hour urine demonstrated a low renal fractional tubular reabsorption of phosphate, increased fractional excretion of uric acid and generalized aminoaciduria. An intravenous bicarbonate loading test suggested the presence of proximal renal tubular acidosis (RTA). These biochemical data indicated Fanconi syndrome with proximal RTA. A kidney biopsy demonstrated t

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Visualization of acetaminophen-induced liver injury by time-of-flight secondary ion mass spectrometry

橋口明典

ANALYTICAL BIOCHEMISTRY （ACADEMIC PRESS INC ELSEVIER SCIENCE） 488 51 - 58 2015年11月

研究論文（学術雑誌）, 共著, ISSN 0003-2697

Time-of-flight secondary ion mass spectrometry (MS) provides secondary ion images that reflect distributions of substances with sub-micrometer spatial resolution. To evaluate the use of time-of-flight secondary ion MS to capture subcellular chemical changes in a tissue specimen, we visualized cellular damage showing a three-zone distribution in mouse liver tissue injured by acetaminophen overdose. First, we selected two types of ion peaks related to the hepatocyte nucleus and cytoplasm using control mouse liver. Acetaminophen-overdosed mouse liver was then classified into three areas using the time-of-flight secondary ion MS image of the two types of peaks, which roughly corresponded to established histopathological features. The ion peaks related to the cytoplasm decreased as the injury became more severe, and their origin was assumed to be mostly glycogen based on comparison with periodic acid Schiff staining images and reference compound spectra. This indicated that the time-of-flight secondary ion MS image of the acetaminophen-overdosed mouse liver represented the chemical changes mainly corresponding to glycogen depletion on a subcellular scale. In addition, this technique also provided information on lipid species related to the injury. These results suggest that time-of-flight secondary ion MS has potential utility in histopathological applications. (C) 2015 Elsevier Inc. All rights reserved.

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C型肝炎関連クリオグロブリン血症に伴う糸球体腎炎の一例

伊藤智章, 脇野修, 徳山博文, 橋口明典, 小西孝之助, 海老沼浩利, 林松彦, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 992 - 992 2015年08月

共著, ISSN 0385-2385

菲薄基底膜病の母を有し、Alport症候群が疑われた一症例

田島敬也, 脇野修, 中谷英章, 徳山博文, 橋口明典, 小西孝之助, 林松彦, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 961 - 961 2015年08月

共著, ISSN 0385-2385

抗甲状腺薬内服中にMPO-ANCAが陽性となった腎症の一例

盛崎瑞葉, 脇野修, 徳山博文, 中谷英章, 橋口明典, 小西孝之助, 林松彦, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 966 - 966 2015年08月

共著, ISSN 0385-2385

両側視力障害を主訴に緊急搬送されRPLSを認めた高血圧合併糖尿病性腎症の1症例

篠塚圭祐, 徳山博文, 橋口明典, 小西孝之助, 脇野修, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 960 - 960 2015年08月

共著, ISSN 0385-2385

ポラプレジンクによる薬剤性急性尿細管間質性腎炎の一例

萩原あいか, 徳山博文, 脇野修, 橋口明典, 小西孝之助, 林晃一, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 954 - 954 2015年08月

共著, ISSN 0385-2385

びまん性大細胞型B細胞性リンパ腫に合併した治療抵抗性IgA腎症の一例

藤井健太郎, 脇野修, 徳山博文, 橋口明典, 小西孝之助, 林松彦, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 1016 - 1016 2015年08月

共著, ISSN 0385-2385

RPGNを呈したPR3-ANCA陽性膜性腎症の一例

村丘寛和, 徳山博文, 橋口明典, 小西孝之助, 林晃一, 脇野修, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 966 - 966 2015年08月

共著, ISSN 0385-2385

MGUS(Monoclonal gammopathy of undetermined significance)(IgMκ)が原因の二次性Fanconi症候群にIgA腎症が合併した一例

田島敬也, 脇野修, 中谷英章, 徳山博文, 橋口明典, 小西孝之助, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 956 - 956 2015年08月

共著, ISSN 0385-2385

ネフローゼ症候群をきたした左副腎偶発腫瘍合併真性多血症の一例

藤井健太郎, 村丘寛和, 宮下和季, 栗原勲, 橋口明典, 小西孝之助, 徳山博文, 脇野修, 伊藤裕

日本腎臓学会誌（(一社)日本腎臓学会） 57 （ 6 ） 954 - 954 2015年08月

共著, ISSN 0385-2385

An unusual association between focal segmental sclerosis and lupus nephritis: a distinct concept from lupus podocytopathy?

Hanaoka H, Hashiguchi A, Konishi K, Kuwana M, Takeuchi T

CEN case reports 4 （ 1 ） 70 - 75 2015年05月

共著, 査読有り

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【病理診断クイックリファレンス】 (第9章)腎(非腫瘍)　膜性腎症

橋口, 明典

病理と臨床 33 （臨増） 132 2015年04月

共著, ISSN 0287-3745

An Efficient Wavelet-Based ROI Coding for Multiple Regions

橋口明典

IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES （IEICE-INST ELECTRONICS INFORMATION COMMUNICATIONS ENG） E98A （ 4 ） 1006 - 1020 2015年04月

研究論文（学術雑誌）, 共著, ISSN 1745-1337

Region of interest (ROI) coding is a useful function for many applications. JPEG2000 supports ROI coding and can decode ROIs preferentially regardless of the shape and number of the regions. However, if the number of regions is quite large, the ROI coding performance of JPEG2000 declines because the code-stream includes many useless non-ROI codes. This paper proposes a wavelet-based ROI coding method suited for multiple ROIs. The proposed wavelet transform does not access any non-ROIs when transforming the ROIs. Additionally, the proposed method eliminates the need for unnecessary coding of the bits in the higher bit planes of non-ROI regions by adding an ROI map to the code-stream. The experimental results show that the proposed method achieves a higher peak signal-to-noise ratio than the ROI coding of JPEG2000. The proposed method can be applied to both max-shift and scaling-based ROI coding.