研究者詳細 - 武林　亨

論文 - 武林　亨

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Specific alcoholic beverage and blood pressure in a middle-aged japanese population: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study

Okamura Tomonori, Tanaka Taichiro, Yoshita Katsushi, Chiba Nagako, Takebayashi Toru, Kikuchi Yuriko, Tamaki Junko, Tamura Unai, Minai Junko, Kadowaki Takashi, Miura Katsuyuki, Nakagawa Hideaki, Tanihara Shinichi, Okayama Akira, Ueshima Hirotsugu, the HIPOP-OHP research group.

Journal of human hypertension 18 （ 1 ） 39341 2004年01月

研究論文（学術雑誌）, 共著, 査読有り

コニカミノルタグループにおける化学物質自主管理とリスク対策の実例

朝武真由美，　武林亨

働く人の安全と健康 54 （ 10 ） 975-980 2003年10月

研究論文（学術雑誌）, 共著

Biological monitoring of indium by means of graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds

Miyaki Koichi, Hosoda Kanae, Hirata Miyuki, Tanaka Akiyo, Nishiwaki Yuji, Takebayashi Toru, Inoue Naohide, Omae Kazuyuki

Journal of Occupational Health 45 （ 4 ） 228 - 230 2003年07月

研究論文（学術雑誌）, 共著, ISSN 1341-9145

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Lack of relationship between occupational exposure to carbon disulfide and endocrine dysfunction: a six-year cohort study of the Japanese rayon workers

Takebayashi Toru, Nishiwaki Yuji, Nomiyama Tetsuo, Uemura Takamoto, Yamauchi Tsuneyuki, Tanaka Shigeru, Sakurai Haruhiko, Omae Kazuyuki, the Japanese Rayon Workers' Health Study Group

Journal of occupational health 45 （ 2 ） 111-118 2003年03月

研究論文（学術雑誌）, 共著

Uptake of cadmium in meals from the digestive tract of young non-smoking Japanese female volunteers

Kikuchi Yuriko, Nomiyama Tetsuo, Kumagai Nami, Dekio Fumiko, Uemura Takamoto, Takebayashi Toru, Nishiwaki Yuji, Matsumoto Yukio, Sano Yuri, Hosoda Kanae, Watanabe Shaw, Sakurai Haruhiko, Omae Kazuyuki

Journal of Occupational Health 45 （ 1 ） 43 - 52 2003年01月

研究論文（学術雑誌）, 共著, ISSN 1341-9145

Objectives - To estimate rates of cadmium (Cd) uptake from the digestive tract and changes in Cd in biological specimens after intake of Cd mainly in rice. Methods - Twenty-five young non-smoking Japanese female volunteers (20-23 in age) were recruited and a 20-d experimental study was conducted. With polished rice containing 0.004 ppm and 0.340 ppm of Cd, Meal L and Meal H were prepared. Approximately 12% of total Cd in Meal L and 92% of total Cd in Meal H originated in rice. The volunteers ate Meal L for 11 d to achieve a stable intake-output balance of Cd. Fifteen of the 25 volunteers ate Meal H on the 12^th day (Group D1), and the remaining 10 ate Meal H on the 12^th, 13^th and 14^th day (Group D3). All 25 subjects then resumed the consumption of Meal L to the end of the study (20^th day). All meals, feces and urine were collected during the study, and Cd intake from the daily meals (Cd-I), Cd in feces (Cd-F) and Cd in urine (Cd-U) were determined. For measurement of Cd in blood (Cd-B), venous blood was collected from all volunteers on the day before the study and again on the 12^th and 20^th day; venous blood was also collected from 4-8 volunteers at additional time points. Results - Mean Cd-I was 4.51 μg/d (range: 1.85-6.93) or 48.48 μg/d (range: 27.98-56.27) when they ate Meal L or Meal H. Cd-F and Cd-B exhibited faster responses to the change in Cd-I than did Cd-U. The Cd_uptake rate, defined as (1-Cd-F_excess/Cd-I_excess) (Fig. 1), was 47.2% (range: -9.4-83.3%) in Group D1 and 36.6% (range: -9.2-73.5%) in Group D3, and the Cd_balance rate, defined as (1-Cd-F_output/Cd-I_intake), was 23.9% (range: -4.0-37.7%) in Group D1 and 23.7% (range: -8.2-56.9%) in Group D3. Conclusions - Cd-F and Cd-B are better biological monitoring parameters for assessing change in Cd-I than Cd-U. The Cd_uptake and Cd_balance rates appeared to be higher than those in previous papers when ingested Cd mainly originated in rice.

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食の安全性を科学する（6）リスクコミュニケーション

武林亨

臨床栄養 101 （ 6 ） 632 2002年12月

研究論文（学術雑誌）, 単著

食の安全性を科学する（5）食品添加物の安全性評価

武林亨

臨床栄養 101 （ 4 ） 376 2002年10月

研究論文（学術雑誌）, 単著

食の安全性を科学する（4）食事摂取基準の許容上限摂取量

武林亨

臨床栄養 101 （ 2 ） 144 2002年08月

研究論文（学術雑誌）, 単著

食の安全性を科学する（3）発がん性の評価

武林亨

臨床栄養 100 （ 7 ） 840 2002年06月

研究論文（学術雑誌）, 単著

食の安全性を科学する（2）ダイオキシン類の一日耐容摂取量

武林亨

臨床栄養 100 （ 4 ） 408 2002年04月

研究論文（学術雑誌）, 単著

食の安全性を科学する（1）Dosis sola facit venenum

武林亨

臨床栄養 100 （ 2 ） 144-144 2002年02月

研究論文（学術雑誌）, 単著

The introduction of an occupational health management system for solving issues in occupational health activities in Japan

Mori Koji, Takebayashi Toru

Industrial Health 40 （ 2 ） 167 - 174 2002年

研究論文（学術雑誌）, 共著, ISSN 0019-8366

An important challenge to occupational health services in Japan is the necessary shift from regulation-based occupational health program to health risk-based program. The Occupational Safety and Health Management System (OSHMS) is an effective tool for introducing risk-based activities. To date, the Five Management system has been used to manage occupational health activities. This classification, however, does not show the interactions among the listed activities. Nor is it clear how this system contributes to the PDCA (Plan/Do/Check/Act) cycle for continual improvement. The category in the Five Management system called "Roles of the Occupational Physician" covers most of the occupational health services required in Japan. The items listed in the Five Management system were compared to the guidelines of OSHMS from the International Labour Office and issues that should be solved for occupational health activities with OSHMS were clarified. Seven issues are discussed in this paper; (1) occupational safety and health policy and audit that can drive the PDCA cycle effectively, (2) reclassification of occupational health activities with several different objectives, (3) set up of targets, (4) risk assessment methods that can prioritize health risks compared to safety risks, (5) exposure assessment methods for risk assessment, (6) flexibility of laws and regulations, and (7) development of talented professionals for risk-based occupational health activities.

Urinary excretion of TTCA after intake of brassica vegetables

Kikuchi Yuriko, Uemura Takamoto, Yamauchi Tsuneyuki, Takebayashi Toru, Nishiwaki Yuji, Yamada Kenichi, Sakurai Haruhiko, Omae Kazuyuki

Journal of Occupational Health 44 （ 3 ） 151 - 155 2002年

研究論文（学術雑誌）, 共著, ISSN 1341-9145

Aim: Recent studies have made it clear that brassica vegetables contain 2-thiothiazolidine-4-carboxylic acid (TTCA), which is the most widely used biological monitoring index of exposure to carbon disulfide (CS₂). This study aimed to assess the time-course of TTCA excretion in urine (TTCA-U) after eating brassica vegetables. Methods: After a 1-d break from eating brassica vegetables, ten volunteers (6 males and 4 females) ingested 100 grams of chopped raw cabbage containing 4.3 mg/kg of TTCA, and the TTCA concentration in urine samples was determined over 24 h. TTCA concentrations in brassica vegetables purchased from a local supermarket were also measured. Results: TTCA-U reached peak concentrations 3-9 h after cabbage intake, gradually decreased, and was below the detection limit (<0.1 mg/l) in 8 of 10 volunteers in the last urine samples. The total amount of TTCA excreted in 24 h ranged from 0.19 to 0.42 mg, and half of the total TTCA was excreted within 6.5 h on average (range: 4.5-10.1). The excretion profiles of young and middle-aged volunteers seemed to differ, but not those of young males and young females. TTCA was detected in both raw and boiled cabbage, Japanese radish, turnip, and broccoli, but was not detected in Chinese cabbage or chingentsuai. Conclusion: TTCA-U may be overestimated as an index of CS₂ exposure when brassica vegetables are ingested within approximately 24 h before collection of the urine sample.

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Four-week inhalation toxicity study of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) in guinea pigs

Kabe Isamu, Takebayashi Toru, Nishiwaki Yuji, Nakajima Tamie, Ikeda Eiji, Saito Takehito, Tanaka Shigeru, Miyauchi Hiroyuki, Endo Yuichi, Omae Kazuyuki

Journal of Occupational Health 43 （ 6 ） 314 - 320 2001年

研究論文（学術雑誌）, 共著, ISSN 1341-9145

Groups of eight male Hartley guinea pigs were exposed to 30, 100 or 300 ppm 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) by inhalation for 6 hours a day for 4 wk. All the animals were sacrificed 48 h postexposure. Guinea pigs exposed to 300 ppm HCFC-123 had significantly lower body weight and the weight gain than controls, but there was no significant difference and no tendency in absolute and relative organ weight. ICDH, ALT and AST, which were the most sensitive indicators of halothane-induced liver injury, did not differ significantly between exposed groups and controls. In the 100 ppm group, a few vacuolar fatty changes in the portal area (zone I) were identified. In the 300 ppm group, severe fatty degeneration was observed in the portal and intermediate areas, partly centrilobule, and the incidence increased significantly compared to the controls. On the other hand, there was no histopathological change in the control or 30 ppm groups. No increase in any of the liver peroxisomal enzymes (AOX, PT, catalase) was seen in male guinea pigs exposed to HCFC-123. The activity of hepatic ALDH was significantly decreased in the 300 ppm exposed group, suggesting that HCFC-123 or its metabolite inhibited ALDH activity. In conclusion, inhalation exposure to 100 ppm or more of HCFC-123 for 4 wk produced nonfatal liver change in guinea pigs, namely hepatic fatty changes predominantly in the portal area (zone I) without any increase in AST, ALT or ICDH. The no-observed-adverse-effect level (NOAEL) of HCFC-123 for four wk in guinea pigs may be 30 ppm. Peroxisome proliferation, which may result in hepatocellular tumor induction, was not observed in guinea pigs exposed to HCFC-123.

Cross-sectional study of health effects of methyl methacrylate monomer among dental laboratory technicians

Nishiwaki Yuji, Saitoh Takehito, Takebayashi Toru, Tanaka Shigeru, Etoh Norihito, Eitaki Yoko, Omae Kazuyuki

Journal of Occupational Health 43 （ 6 ） 375 - 378 2001年

研究論文（学術雑誌）, 共著, ISSN 1341-9145

Relationship between the blood coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population.

Nishiwaki Y., Takebayashi T., Omae K., Ishizuka C., Nomiyama T., Sakurai H.

Journal of epidemiology / Japan Epidemiological Association 10 （ 1 ） 34 - 41 2000年01月

研究論文（学術雑誌）, 共著, ISSN 0917-5040

A cross-sectional observation was performed to assess the relationship between the coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population. Subjects were 445 workers (18.9-49.4, Av. 36.2 yrs) in viscose rayon manufacturing factories in Japan. Coagulation-fibrinolysis parameters determined were D-dimer(DD), thrombin antithrombin III complex (TAT), tissue plasminogen activator (TPA), and plasminogen activator inhibitor 1 (PAI1). The following indicators of arteriosclerosis were examined; systolic and diastolic blood pressure (SBP, DBP), stiffness parameter of the carotid artery using ultrasound (beta), pulse wave velocity of the aorta (PWV), and a number of lacunar infarctions from brain MRI. After age-stratification(-29, 30-39, 40+ yrs), the subjects were classified into quartiles by coagulation-fibrinolysis parameters. The mean values of SBP and DBP and beta and PWV, the prevalence of brain infarctions were compared across these quartiles by means of analysis of variance, chi-square test, respectively. Multivariate analysis was also employed to adjust other risk factors. In conclusion, SBP and DBP and beta, PWV were elevated by increase of PAI1, TAT, respectively, in the 40+ years group even after adjustment for other possible risk factors. DD had no relation to any of the indicators of arteriosclerosis. None of the coagulation-fibrinolysis parameters had any relation to brain infarctions.

Acute and recurrent hepatitis induced by 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123)

Omae K., Takebayashi T., Tanaka S., Sasaki K., Miyauchi H., Kabe I., Taneichi K., Shibaki H.

Journal of Occupational Health 42 （ 5 ） 235 - 238 2000年

研究論文（学術雑誌）, 共著, ISSN 1341-9145

A 49-yr-old female cleaning worker first visited a hospital because of acute hepatitis. On admission, laboratory examination revealed severe hepatic damage (AST 2125 IU/L, ALT 2391 IU/L, LDH 1279 IU/L, t-Bil 8.5 mg/d/), but failed to disclose any evidence of viral infection or morphological lesions. She recovered day by day without any specific treatment for hepatitis and was discharged one month later. On the 11th day after restarting her job, she was readmitted due to similar symptoms and signs. Serum biochemistry data again showed severe liver damage (AST 1354, ALT 1604, LDH 1119 t-Bil 2.6). Histopathological diagnosis based on hepatic needle biopsy was chronic active hepatitis with diffuse infiltration of lymphocyte-dominant inflammatory cells, bridging necrosis, intercellular fibrosis in a limited region, and with ballooning, degeneration, and/or necrosis of the hepatic cells. A job-related cause was suspected and 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123), which has been proven to cause acute hepatitis in humans, was detected in a dry-cleaning solvent by gas chromatography-mass spectrometry analysis. A job simulation experiment suggested that the concentration of the patient's exposure to HCFC-123 exceeded 1,000 ppm during the busiest work period, which was sufficiently high to induce severe liver damage.

Relationship between the blood coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population

Nishiwaki Yuji, Takebayashi Toru, Omae Kazuyuki, Ishizuka Chizuru, Nomiyama Tetsuo, Sakurai Haruhiko

Journal of Epidemiology 10 （ 1 ） 34 - 41 2000年

研究論文（学術雑誌）, 共著, ISSN 0917-5040

A cross-sectional observation was performed to assess the relationship between the coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population. Subjects were 445 workers (18.9-49.4, Av.36.2yrs) in viscose rayon manufacturing factories in Japan. Coagulation-fibrinolysis parameters determined were D-dimer(DD), thrombin antithrombinlï ï complex (TAT), tissue plasminogen activator fTPA), and plasminogen activator inhibitor 1 (PAH). The following indicators of arteriosclerosis were examined; systolic and diastolic blood pressure (SBP, DBP), stiffness parameter of the carotid artery using ultrasound (, ?), pulse wave velocity of the aorta (PWV), and a number of lacunar infarctions from brain MRI. After age-stratification(-29, 30-39, 40+yrs), the subjects were classified into quartiles by coagulation-fibrinolysis parameters. The mean values of SBP and DBP and and PWV , the prevalence of brain infarctions were compared across these quartiles by means of analysis of variance, chi-square test, respectively. Multivariate analysis was also employed to adjust other risk factors. In conclusion, SBP and DBP and, ?, PWV were elevated by increase of PAH, TAT, respectively, in the 40+ years group even after adjustment for other possible risk factors. DD had no relation to any of the indicators of arteriosclerosis. None of the coagulation-fibrinolysis parameters had any relation to brain infarctions.

Difference by instructional set in stabilometry

Nishiwaki Yuji, Takebayashi Toru, Imai Azusa, Yamamoto Masahiko, Omae Kazuyuki

Journal of Vestibular Research: Equilibrium and Orientation 10 （ 3 ） 157 - 161 2000年

研究論文（学術雑誌）, 共著, ISSN 0957-4271

There is no standard for the awareness of standing posture in stabilometry, yet little research addressing the matter has been carried out. In the present study, we evaluated the influence of different instructional sets during, a test on stabilometry. Stabilometry was performed on 349 male subjects. Two different instructions were prepared for the subjects regarding the awareness of their standing posture. These instructions were a) 'Please relax when you stand' (R-standing), and b) 'Please make an effort to minimize your body sway' (E-standing). Subjects were classified into four groups according to the combination of these instructions they received. For the five body sway parameters, a comparison between R-standing and E-standing was performed, controlling for possible confounders such as age, height, body weight, educational history, alcohol consumption, and smoking status. The sway length in E-standing was larger than that in R-standing, even after the adjustment for possible confounders. Our results indicate that the difference in the instructional set caused a significant measurement bias. Thorough-going unification of instructions for the stabilometry should be recommended when stabilometry is performed in an epidemiological investigation.

第6次改定日本人の栄養所要量─食事摂取基準：フッ素

武林亨

臨床栄養 95 （ 6 ） 716-719 1999年11月

研究論文（学術雑誌）, 単著

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