研究者詳細 - 武林　亨

論文 - 武林　亨

分割表示 208 件中 81 - 100 件目／全件表示 >>

Prism adaptation therapy enhances rehabilitation of stroke patients with unilateral spatial neglect

Mizuno Katsuhiro, Tsuji Tetsuya, Takebayashi Toru, Fujiwara Toshiyuki, Hase Kimitaka, Liu Meigen

Neurorehabilitation and Neural Repair 25 （ 8 ） 711 - 720 2011年10月

研究論文（学術雑誌）, 共著, ISSN 1545-9683

Background and objective. Unilateral spatial neglect (USN) can interfere with rehabilitation processes and lead to poor functional outcome. The purpose of this study was to determine whether prism adaptation (PA) therapy improves USN and functional outcomes in stroke patients in the subacute stage. Methods. A multicenter, double-masked, randomized, controlled trial was conducted to evaluate the effects of a 2-week PA therapy on USN assessed with the Behavioral Inattention Test (BIT), the Catherine Bergego Scale (CBS), and activities of daily living (ADL) as evaluated with the Functional Independence Measure (FIM). A total of 38 USN patients with right-brain damage were divided into prism (n = 20) and control (n = 18) groups. Patients were divided into mild and severe USN groups according to BIT behavioral test (mild 55 and severe<55). The prism group performed repetitive pointing with prism glasses that induce rightward optical shift twice daily, 5 days per week, for 2 weeks, whereas the control group performed similar pointing training with neutral glasses. Results. The FIM improved significantly more in the prism group. In mild USN patients, there was significantly greater improvement of BIT and FIM in the prism group. Conclusions. PA therapy can significantly improve ADL in patients with subacute stroke. © 2011 American Society of Neurorehabilitation.

Access to Document (DOI)

Acoustic neuroma risk in relation to mobile telephone use: Results of the INTERPHONE international case-control study

武林　亨

CANCER EPIDEMIOLOGY 35 （ 5 ） 453 - 464 2011年10月

研究論文（学術雑誌）, ISSN 1877-7821

Access to Document (DOI)

Association of short sleep duration with impaired glucose tolerance or diabetes mellitus

Katano Sayuri, Nakamura Yasuyuki, Nakamura Aki, Murakami Yoshitaka, Tanaka Taichiro, Takebayashi Toru, Okayama Akira, Miura Katsuyuki, Okamura Tomonori, Ueshima Hirotsugu

Journal of Diabetes Investigation 2 （ 5 ） 366 - 372 2011年10月

研究論文（学術雑誌）, 共著, ISSN 2040-1116

Aims/Introduction: To examine the cross-sectional relationship between sleep duration and impaired glucose tolerance (IGT), including diabetes mellitus (DM), we analyzed a large-scale healthy workers database in Japan. Materials and Methods: We examined the baseline database of 4143 participants (3415 men and 728 women) aged 19-69years. Sleep duration of participants was categorized into four groups: <6, 6 to <7, 7 to <8 and ≥8h. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ). We defined IGT including DM (IGT/DM) in the present study according to previous studies as follows: fasting blood sugar level ≥110mg/dL, or if <8h after meals ≥140mg/dL, or on medication for diabetes mellitus, or those diagnosed as having DM. Logistic regression was applied to estimate the odds ratio (OR) to examine the relationship between IGT/DM, sleep duration and other related factors. Results: The number of participants with IGT/DM was 402 (9.7%). The factors that significantly associated with IGT/DM were age (OR 1.08, 95% confidence interval [CI] 1.07-1.10, P<0.001), high blood pressure (OR 1.94, CI 1.52-2.47, P<0.001), and <6h of sleep duration in comparison with 6 to <7h sleep (OR 2.32, CI 1.18-4.55, P=0.015). The associations of difficulty in sleep initiation, IPAQ classification, current smoking and alcohol intake with IGT/DM were not statistically significant. Conclusions: Our results showed that shorter sleep duration (<6h of sleep duration per night) was associated with a risk of IGT/DM independent of other lifestyle habits and metabolic risk factors. © 2011 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd.

Access to Document (DOI)

Are you conscious of any age-related taste impairment? Prevalence of and factors associated with taste impairment in Japan

Michikawa Takehiro, Nishiwaki Yuji, Takebayashi Toru

Journal of the American Geriatrics Society 59 （ 5 ） 951 - 953 2011年05月

研究論文（学術雑誌）, 共著, ISSN 0002-8614

Access to Document (DOI)

Knee Pain and Future Self-Reliance in Older Adults: Evidence From a Community-Based 3-Year Cohort Study in Japan

TAKEBAYASHI TORU

JOURNAL OF EPIDEMIOLOGY 21 （ 3 ） 184 - 190 2011年05月

研究論文（学術雑誌）, ISSN 0917-5040

Access to Document (DOI)

Impact of hearing difficulty on dependence in activities of daily living (ADL) and mortality

Yamada Mutsuko, Nishiwaki Yuji, Michikawa Takehiro, Takebayashi Toru

Archives of Gerontology and Geriatrics 52 （ 3 ） 245 - 249 2011年05月

研究論文（学術雑誌）, 共著, ISSN 0167-4943

Studies have associated hearing impairment with adverse health outcomes, but the actual impact of hearing difficulty has been barely investigated. We investigated among older adults (i) the prevalence of hearing difficulty, (ii) the association of hearing difficulty with a composite outcome of dependence in activities of daily living (ADL) and death, and (iii) the population attributable risk fraction (PAF) of hearing difficulty. In 2005, a home-visit survey of 1364 Japanese older adults aged ≥65 (participation proportion = 95.5%) was conducted to evaluate self-reports of hearing difficulty. Over 3 years, 99.4% of the initial sample was followed. Outcomes were measured by incidence of death or dependence in ADL. In the sample, the prevalence of hearing difficulty was 17.7% (age ≥65) and 25.7% (age ≥75). Hearing difficulty at high levels was associated with a composite outcome of dependence in ADL and mortality (adjusted odds ratio = OR and 95% confidence interval = 95% CI = 6.19 (1.92-19.92)) as well as with each outcome independently. Improving the hearing difficulty from high to moderate or no difficulty would reduce the composite outcome in 4.3% (age ≥65) and in 6.3% (age ≥75) of the target population. In conclusion, hearing difficulty was common, was associated with and had substantial impact on adverse health outcomes. © 2010 Elsevier Ireland Ltd.

Access to Document (DOI)

Etiological difference between ultrashort- and short-segment Barrett's esophagus

Matsuzaki Juntaro, Suzuki Hidekazu, Asakura Keiko, Saito Yoshimasa, Hirata Kenro, Takebayashi Toru, Hibi Toshifumi

Journal of Gastroenterology 46 （ 3 ） 332 - 338 2011年03月

研究論文（学術雑誌）, 共著, ISSN 0944-1174

Background: Barrett's esophagus has been divided into three categories based on the extent of the metaplasia: long-segment (LSBE), short-segment (SSBE), and ultrashort-segment Barrett's esophagus (USBE). While both LSBE and SSBE are thought to be induced by gastroesophageal reflux, the etiology of USBE is still unclear. Methods: We conducted a case-control study to identify the differences in the pathogenesis between SSBE and USBE in a hospital-based population. The endoscopic findings and clinical factors of 199 patients with short-segment endoscopically suspected esophageal metaplasia (SS-ESEM) and 317 patients with ultrashort-segment ESEM (US-ESEM) were compared with those of 199 and 317 age- and gender-matched patients without ESEM. Results: The severity of gastric mucosal atrophy was marginally associated with the presence of US-ESEM [odds ratio (OR) 1.20, 95% confidence interval (CI) 0.98-1.46, p = 0.08], but not with that of SS-ESEM. On the other hand, the presence of gallstones and that of severe reflux esophagitis were associated with the presence of SS-ESEM (OR 2.19, 95% CI 1.21-3.98; OR 1.72, 95% CI 1.08-2.75), but not with that of US-ESEM. Presence of gastric corpus atrophy without gallstones was associated with the presence of US-ESEM, but not with that of SS-ESEM. Conclusions: Presence of gastric corpus atrophy was associated with an increased likelihood of the presence of US-ESEM, whereas the presence of gallstones was associated with an increased likelihood of the presence of SS-ESEM, suggesting difference in etiology between US- and SS-ESEM. © 2010 Springer.

Access to Document (DOI)

Body mass index misclassification due to kyphotic posture in Japanese community-dwelling adults aged 65 years and older

Nishiwaki Yuji, Michikawa Takehiro, Eto Norihito, Takebayashi Toru

Journals of Gerontology - Series A Biological Sciences and Medical Sciences 66 A （ 3 ） 326 - 331 2011年03月

研究論文（学術雑誌）, 共著, ISSN 1079-5006

Background: In older adults, kyphosis (slouching posture) can lead to underestimation of height, which may in turn lead to overestimation of body mass index (BMI). We investigated the extent to which inaccurate BMI assessments led to misclassification of elderly people as normal weight (when they were actually underweight) or overweight (actually normal weight). Methods: Anthropometric measurements were taken in 2005 and 2006 for 842 residents aged 65 years or older (women: 491; men: 351). We calculated BMI from measured height and weight (observed BMI) and then predicted BMI from height as determined by demi-span, which is unaffected by kyphosis (predicted BMI). Kyphosis was assessed by the number of blocks placed under the occiput required for the supine participant to achieve a neutral head position. Participants were classified as underweight (BMI < 18.5), normal weight, or overweight (BMI ≥ 25.0) according to both observed and predicted BMI; classification accordance was investigated by cross-tabulation. Results. Kyphosis was present in 17.2% of the participants overall and in 23.6% of those aged 75 years or older. Predicted BMI measurements showed that 11 % of participants with kyphosis requiring ≥ 3 blocks were misclassified as normal weight and that 10% were erroneously classified as overweight. In those aged 75 years or older, the corresponding figures were 15% and 12%. Conclusions. Our results suggest that inaccurate BMIs due to kyphosis lead to substantial numbers of older adults being misclassified as normal weight or overweight, which can cause significant distortions in data on the impact of underweight and overweight on health outcomes. © The Author 2011. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

Access to Document (DOI)

[Epidemiologic review of long-term, low-level exposure to environmental chemicals and cardiovascular disease

Takebayashi Toru

Nihon eiseigaku zasshi. Japanese journal of hygiene 66 （ 1 ） 13 - 21 2011年01月

研究論文（学術雑誌）, 共著

The effects of exposure to environmental chemicals, such as heavy metals and fine particulates, on cardiovascular diseases have been reported. To set a permissible exposure standard, an exposure-response relationship should be elucidated. Thus, epidemiologic evidence in relation to long-term, low-level exposure to environmental chemicals (i.e., lead, cadmium, mercury, arsenic, PM(2.5), carbon disulfide) was reviewed. As a result, there exists a clear exposure-response relationship between exposure to lead or PM(2.5) and cardiovascular diseases, but those cohort studies were carried out in the US only. From epidemiologic viewpoint, "consistency" of the observed relationship must be clarified, especially findings of a study in the Japanese population. It is well known that the distribution pattern of cardiovascular risk factors are quite different between two countries, which could modify the true relationship. This will require studies of large samples from the general Japanese population with control for potential confouders. Moreover, to detect a small effect of exposure within low-level range, random misclassification of exposure as well as that of effect must be minimized. Thus, for studies of heavy metals, sensitive biomarkers identified in toxicological studies would be applied. For PM(2.5), a wide range of population samples should be covered by a national sampling network in the near future. Finally, the integration of epidemiologic and toxicological evidence would be more important for risk assessment of environmental chemicals at low exposure levels, because an exposure-response relationship from only epidemiologic observation may be unstable with a wide confidence interval around the threshold.

Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis

Watanabe Toshiaki, Ajioka Yoichi, Matsumoto Takayuki, Tomotsugu Naoki, Takebayashi Toru, Inoue Eisuke, Iizuka Bunei, Igarashi Masahiro, Iwao Yasushi, Ohtsuka Kazuo, Kudo Shin Ei, Kobayashi Kiyonori, Sada Miwa, Matsumoto Takayuki, Hirata Ichiro, Murakami Kazunari, Nagahori Masakazu, Watanabe Kenji, Hida Nobuyuki, Ueno Fumiaki, Tanaka Shinji, Watanabe Mamoru, Hibi Toshifumi

Journal of Gastroenterology 46 （ SUPPL. 1 ） 11 - 16 2011年01月

研究論文（学術雑誌）, 共著, ISSN 0944-1174

Colorectal cancer is one of the complications of ulcerative colitis (UC) and the risk of cancer increases as the duration of the disease becomes longer. Surveillance colonoscopy has been considered to be important for the early detection and early treatment of colorectal cancer, especially in longstanding UC. Because it is not always easy to detect neoplastic lesions in UC endoscopically, guidelines recommend the use of step biopsy in surveillance, in which either 4 biopsy specimens for every 10 cm or a total of 33 or more biopsy specimens are obtained. However, it has been pointed out that a step biopsy obtaining several tens of biopsy specimens may not be an ideal method in terms of invasiveness to the patient or medical cost. Instead of step biopsy, recent studies report the usefulness of target biopsy, in which biopsy tissues are obtained only from regions suspected of neoplasia. Therefore, the Research Group for Intractable Inflammatory Bowel Disease of the Ministry of Health, Labour and Welfare of Japan has initiated a randomized controlled study to compare the efficacy of step biopsy and target biopsy. The present article gives an introduction to this ongoing randomized controlled trial in Japan. © 2010 Springer.

Access to Document (DOI)

[Treatment indications for sarcopenia: a systematic review of exercise intervention effect]

Miyachi Motohiko, Ando Daisuke, Oida Yukio, Oguma Yuko, Ono Rei, Kitabatake Yoshinori, Tanaka Kiyoji, Nishiwaki Yuji, Michikawa Takehiro, Yanagita Masahiko, Yoshimura Kimio, Takebayashi Tohru

Japanese Journal of Geriatrics 48 （ 1 ） 51 - 54 2011年

ISSN 0300-9173

Objective: To evaluate exercise intervention efficacy for the prevention and treatment of sarcopenia in the elderly. Methods: We conducted a systematic literature search of randomized controlled trials in the Physical Activity Guidelines Advisory Committee Report (before 2007), Pubmed, the Cochrane database, and Igaku Chuo Zasshi (January 2006 to August 2009) Data Extraction: Two authors independently extracted relevant data. A total of 951 articles were found by search engines, and 9 studies were finally selected after a review by 2 experts. The content of these studies, especially duration, sets, periods, frequency, and intensity of exercise intervention were extracted and summarized in a results table. Five of 6 articles concluded that high-intensity resistance training significantly increased soft lean tissue and muscle mass. The remaining 3 articles indicated that moderate-intensity resistance training did not affect soft lean tissue or muscle mass. Conclusion: This systematic review suggested that high-intensity resistance training with sufficient periods, frequency, repetitions, and sets is effective to counteract the loss of muscle mass associated with advancing age.

Access to Document (DOI)

Relationship between dietary and other lifestyle habits and cardiometabolic risk factors in men

Katano Sayuri, Nakamura Yasuyuki, Okuda Nagako, Murakami Yoshitaka, Chiba Nagako, Yoshita Katsushi, Tanaka Taichiro, Tamaki Junko, Takebayashi Toru, Okayama Akira, Miura Katsuyuki, Okamura Tomonori, Ueshima Hirotsugu

Diabetology and Metabolic Syndrome 3 （ 1 ） 2011年

研究論文（学術雑誌）, 共著

Background: Prevalence of men with cardiometabolic risk factors (CMRF) is increasing in Japan. Few studies have comprehensively examined the relation between lifestyles and CMRF. Methods. We examined the baseline data from 3,498 male workers ages 19 to 69 years who participated in the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study at 12 large-scale companies throughout Japan. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ). Dietary intake was surveyed by a semi-quantitative Food Frequency Questionnaire. We defined four CMRF in this study as follows: 1) high blood pressure (BP): systolic BP 130 mmHg, or diastolic BP ≥85 mmHg, or the use of antihypertensive drugs; 2) dyslipidemia: high-density lipoprotein-cholesterol concentration < 40 mg/dl, or triglycerides concentration ≥150 mg/dl, or on medication for dyslipidemia; 3) impaired glucose tolerance: fasting blood sugar concentration ≥110 mg/dl; 4) obese: a body mass index ≥25 kg/m ². Results: Those who had 0 to 4 CMRF accounted for 1,597 (45.7%), 1,032 (29.5%), 587 (16.8%), 236 (6.7%), and 44 (1.3%) participants, respectively, in the Poisson distribution. Poisson regression analysis revealed that independent factors that contributed to the number of CMRF were age (b = 0.020, P < 0.01), IPAQ (b = -0.091, P < 0.01), alcohol intake (ml/day) (b = 0.001, P = 0.03), percentage of protein intake (b = 0.059, P = 0.01), and total energy intake (kcal)(b = 0.0001, P < 0.01). Furthermore, alcohol intake and its frequency had differential effects. Conclusions: Alcohol intake, percent protein and total energy intake were positively associated, whereas drinking frequency and IPAQ were inversely associated, with the number of CMRF. © 2011 Katano et al; licensee BioMed Central Ltd.

Access to Document (DOI)

Vitamin D deficiency and lifestyle factors in the oldest old

Sumiya Chieko, Arai Yasumichi, Takayama Michiyo, Abe Yukiko, Hirose Nobuyoshi, Asakura Keiko, Nishiwaki Yuji, Takebayashi Toru

Journal of the American Geriatrics Society 58 （ 11 ） 2242 - 2244 2010年11月

研究論文（学術雑誌）, 共著, ISSN 0002-8614

Access to Document (DOI)

Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population

Nagahori Masakazu, Hyun Sea Bong, Totsuka Teruji, Okamoto Ryuichi, Kuwahara Erika, Takebayashi Toru, Naganuma Makoto, Watanabe Mamoru

Journal of Gastroenterology 45 （ 10 ） 1008 - 1013 2010年10月

研究論文（学術雑誌）, 共著, ISSN 0944-1174

Background: Metabolic syndrome (MS) is associated with an increased risk of cardiovascular disease. However, its prevalence in inflammatory bowel disease (IBD) patients remains largely unknown. This study was planned to determine the prevalence of MS in Japanese IBD patients. Methods: The prevalence of MS among outpatients with IBD aged 18 or older was studied using the modified National Cholesterol Education Program Adult Treatment Panel III definition. Results: A total of 107 quiescent IBD patients, including 76 ulcerative colitis (UC) patients and 31 Crohn's disease (CD) patients, were studied. Sufficient data were collected from a total of 102 patients. Prevalence of MS was significantly higher in UC (23.0%) patients compared to CD patients (7.1%). MS prevalence was substantially higher among male IBD patients (21.1%) compared to female IBD patients (12.9%), particularly in patients over 30 years of age. No difference was observed in the prevalence of MS between our IBD cohort and the general population in both males and females aged 40 years and older (P = 0.707 in males, P = 0.328 in females). IBD patients with MS were also older than those without (50.2 ± 15.0 vs. 38.0 ± 11.9 years, P = 0.013). In a logistic regression analysis, age was the statistically significant predictor of MS among IBD patients. The odds ratio (95% confidence interval) was 1.064 (1.017-1.114). Conclusions: Prevalence of metabolic syndrome in our IBD patients was comparable to that of the general population. Because age was the independent risk factor for developing MS, evaluation for MS is needed for elderly IBD patients. © 2010 Springer.

Access to Document (DOI)

Inflammatory bowel disease in children

Ishige Takashi, Tomomasa Takeshi, Takebayashi Tohru, Asakura Keiko, Watanabe Mamoru, Suzuki Tomoko, Miyazawa Reiko, Arakawa Hirokazu

Journal of Gastroenterology 45 （ 9 ） 911 - 917 2010年09月

研究論文（学術雑誌）, 共著, ISSN 0944-1174

Objective: We analyzed the database of the Japanese nationwide inflammatory bowel disease (IBD) registry, which was started in 1975, to characterize basic epidemiological and clinical features of childhood IBD, comparing them to those in adults. Study design: We analyzed the age of disease onset, disease severity and anatomical distribution in patients that were newly registered between 2003 and 2006 (n = 2,940 for CD and 14,857 for UC). We also analyzed the current age, gender and family history of IBD of all patients filed in 2005, which included patients who were newly registered in 2005 and those who had been registered before 2005 and for whom an annual report had been received in 2005 (total number of subjects: 10,934 for CD and 37,846 for UC). Results: At the time of registration, 10.6% of CD and 5.9% of UC patients were ≤16 years old. In CD, the male to female ratio was 2.6 in adult- and 1.7 in childhood-onset patients (P < 0.001). In UC, the male to female ratio was close to 1 in both age groups. In comparison with adults, pediatric patients more commonly had a positive family history for CD and UC (P < 0.001), tended to have more severe disease at the time of registry (P < 0.001 for CD, P < 0.05 for UC) and more often had extensive colitis in UC (P < 0.001). Conclusion: The nationwide registry in Japan showed IBD in children has clinical features that are distinct from those in adults. © 2010 Springer.

Access to Document (DOI)

Relationship among physical activity, smoking, drinking and clustering of the metabolic syndrome diagnostic components

Katano Sayuri, Nakamura Yasuyuki, Nakamura Aki, Murakami Yoshitaka, Tanaka Taichiro, Nakagawa Hideaki, Takebayashi Toru, Yamato Hiroshi, Okayama Akira, Miura Katsuyuki, Okamura Tomonori, Ueshima Hirotsugu

Journal of Atherosclerosis and Thrombosis 17 （ 6 ） 644 - 650 2010年06月

研究論文（学術雑誌）, 共著, ISSN 1340-3478

Aim: To examine the relation between lifestyle and the number of metabolic syndrome (MetS) diagnostic components in a general population, and to find a means of preventing the development of MetS components. Methods: We examined baseline data from 3,365 participants (2,714 men and 651 women) aged 19 to 69 years who underwent a physical examination, lifestyle survey, and blood chemical examination. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ). We defined four components for MetS in this study as follows: 1) high BP: systolic BP ≥ 130 mmHg or diastolic BP ≥85 mmHg, or the use of antihypertensive drugs; 2) dyslipidemia: high-density lipoprotein-cholesterol concentration <40 mg/dL, triglycerides concentration ≥150 mg/dL, or on medication for dyslipidemia; 3) Impaired glucose tolerance: fasting blood sugar level ≥110 mg/d, or if less than 8 hours after meals ≥140 mg/dL), or on medication for diabetes mellitus; 4) obesity: body mass index ≥25 kg/m². Results: Those who had 0 to 4 MetS diagnostic components accounted for 1,726, 949, 484, 190, and 16 participants, respectively, in the Poisson distribution. Poisson regression analysis revealed that independent factors contributing to the number of MetS diagnostic components were being male (regression coefficient b = 0.600, p<0.01), age (b = 0.027, p<0.01), IPAQ class (b = -0.272, p = 0.03), and alcohol consumption (b = 0.020, p = 0.01). The contribution of current smoking was not statistically significant (b = -0.067, p = 0.76). Conclusion: Moderate physical activity was inversely associated with the number of MetS diagnostic components, whereas smoking was not associated.

Conception outcomes and opinions about pregnancy for men with inflammatory bowel disease

Sato Asaka, Naganuma Makoto, Asakura Keiko, Nishiwaki Yuji, Yajima Tomoharu, Hisamatsu Tadakazu, Iwao Yasushi, Takebayashi Toru, Watanabe Mamoru, Hibi Toshifumi

Journal of Crohn's and Colitis 4 （ 2 ） 183 - 188 2010年06月

研究論文（学術雑誌）, 共著, ISSN 1873-9946

Background and aims: Patients with inflammatory bowel disease (IBD) who want to have children are anxious to receive medical treatment. The consensus regarding pregnancy has not been surveyed for male IBD patients. The present study was investigated opinions among male IBD patients about pregnancy, conception and neonatal outcomes for partners. Methods: Subjects comprised 364 of 386 patients enrolled (94.3%). Subjects received a questionnaire regarding their opinions and thoughts about pregnancy. The course of partner's conceptions and presence of neonatal malformations was also surveyed. Results: The rate of live births for partners of male IBD patients was 91.6% (219/239). Most patients with CD (29/33; 88%) had their children after surgery had been performed. The rate of expressing hopes to have a child tended to be higher for patients with UC (93/128; 73%) than for patients with CD (61/97; 63%; p = 0.21). Furthermore, the rate of hesitation was significantly higher in CD patients (34/107; 32%) than in UC patients (38/188; 20%; p = 0.03).Patients considered that safety of medication (51%) and maintenance of remission (41%) was more important than receiving no treatment for IBD (19%) when planning to conceive. Mesalamine and infliximab were more favorable at conception than sulfasalazine and immunomodulators. Conclusions: This is the first report to survey the thinking of male IBD patients regarding pregnancy. Most male IBD patients considered "maintaining remission" as important at conception. Our study provides important information for IBD patients and for the treating physician when planning to conceive. © 2009 European Crohn's and Colitis Organisation.

Access to Document (DOI)

Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study

The INTERPHONE study group

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 39 （ 3 ） 675 - 694 2010年06月

研究論文（学術雑誌）, ISSN 0300-5771

Access to Document (DOI)

Gallstones increase the prevalence of Barrett's esophagus

Matsuzaki Juntaro, Suzuki Hidekazu, Asakura Keiko, Saito Yoshimasa, Hirata Kenro, Takebayashi Toru, Hibi Toshifumi

Journal of Gastroenterology 45 （ 2 ） 171 - 178 2010年02月

研究論文（学術雑誌）, 共著, ISSN 0944-1174

Purpose: Bile and acid exposures are thought to be major risk factors for Barrett's esophagus in Western countries. The association of gallstones with Barrett's esophagus has not been fully evaluated. The present study was designed as a case-control study for determining the possible factors associated with endoscopically suspected esophageal metaplasia (ESEM), defined as an endoscopic finding suggestive of Barrett's esophagus, in Japanese patients. Methods: A total of 528 patients with ESEM were allocated to the case group, while 528 age- and gender-matched patients without ESEM were allocated to the control group. Findings on esophagogastroduodenoscopy and clinical background factors were compared using a multivariate logistic regression model. Results: The presence of gallstones and hiatus hernia and the severity of gastric mucosal atrophy were independently associated with the presence of ESEM [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.03-2.69; OR 2.75, 95% CI 1.75-4.33; OR 1.25, 95% CI 1.01-5.6, respectively]. Compared with subjects with neither gastric corpus atrophy nor gallstones, although subjects with gallstones alone were not associated with the presence of ESEM (OR 1.59, 95% CI 0.87-2.92), having both gastric corpus atrophy and gallstones was strongly associated with the presence of ESEM (OR 2.94, 95% CI 1.40-6.17). Conclusions: The presence of gallstones was independently associated with the presence of ESEM in the Japanese outpatient population, suggesting a causal association of distal esophageal bile exposure with the development of ESEM. Further studies are needed to confirm our findings in cases with histologically confirmed Barrett's esophagus. © 2009 Springer.

Access to Document (DOI)

Nine-month observation of effects of SO2 on the respiratory system in child Miyakejima citizens

Iwasawa Satoko, Michikawa Takehiro, Nakano Makiko, Nishiwaki Yuji, Tsuboi Tazuru, Tanaka Shigeru, Uemura Takamoto, Milojevic A., Nakashima Hiroshi, Takebayashi Toru, Morikawa Akihiro, Maruyama Kouichi, Kudo Shoji, Uchiyama Iwao, Omae Kazuyuki

[Nippon kōshū eisei zasshi] Japanese journal of public health 57 （ 1 ） 39 - 43 2010年01月

研究論文（学術雑誌）, 共著, ISSN 0546-1766

BACKGROUND: Mt. Oyama on Miyakejima Island erupted in June 2000 and all Miyake village citizens were forced to evacuate the island in the September, due to continuous eruptions and emission of unsafe amounts of volcanic gas, mainly sulfur dioxide (SO2). Beginning in February 2005, residents returned to live on the island despite the fact that volcanic gas was still being emitted. OBJECTIVE: To examine changes in the respiratory systems of included children from February 2006 to November 2006. METHODS: The study population was 141 children who participated in health checkups in November 2006, including 33 SO2 hypersusceptible children who had a current or past history of asthma, obstructive lung function, current symptoms of whistling and wheezing, and/or deterioration of respiratory symptoms. Respiratory effects were evaluated by a questionnaire for respiratory symptoms and by spirometry. SO2 was monitored at 7 sampling points within inhabited areas, and the mean SO2 concentration from February 2005 to November 2006 was 0.031 ppm. The area was categorized into four areas by average SO2 concentration, namely, areas L, H-1, H-2, and H-3, where the average SO2 levels were 0.019, 0.026, 0.032, and 0.045 ppm, respectively. RESULTS: Compared to children in area L, the frequencies of "phlegm" and "irritation of the nose" were significantly greater in the children in areas H-2 and H-3. %FVC and %FEV1 in hypersusceptible children were significantly reduced in November 2006 as compared to February 2006 (P = 0.047, 0.027), though no reduction observed in normosusceptible children. CONCLUSION: Respiratory functions in hypersusceptible Miyakejima children may be affected by SO2 exposure, and further follow-up observation is necessary.

　前のページ - 次のページ　

武林 亨

論文 - 武林 亨

武林　亨

論文 - 武林　亨