論文 - 武林　亨

Association between visual classification of kyphosis and future ADL decline in community-dwelling elderly people: the Kurabuchi study

Sugai K., Michikawa T., Takebayashi T., Matsumoto M., Nakamura M., Nishiwaki Y.

Archives of Osteoporosis （Archives of Osteoporosis）  14 （ 1 ）  2019年12月

ISSN  18623522

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© 2018, The Author(s). Summary: This cohort study conducted in Japan showed that severe age-related kyphosis was visually detected. The visual assessment of kyphosis was associated with declines in ADL, suggesting that we can easily identify people at high risk to develop future ADL reduction in the community setting. Purpose: Age-related kyphosis is related with declines in activities of daily living (ADL). Its conventional diagnosis has been made by orthopedic surgeons and trained examiners using specialized equipment such as X-rays. We investigated whether visual classification of kyphosis by laypersons accurately predicted future ADL decline. Methods: This study was part of the Kurabuchi Study, a cohort study of community-dwelling elderly Japanese. Between 2009 and 2010, three layperson raters used reference illustrations to classify 532 participants without ADL decline at study baseline into four categories. Other examiners used conventional methods to assess kyphosis in the same participants: curve ruler, Spinal Mouse, and the block method. ADL decline was defined as the development of dependence according to the Katz Index, admission to a nursing home, or certification of long-term care need. Results: Thirty-five of the participants (6.6%) were classified with the most severe degree of kyphosis at baseline by visual assessment. Interrater agreement was high (Kappa = 0.73) for the most severe group. During 4.5 years of follow-up, 106 participants (19.9%) showed ADL decline. On the basis of visual assessment, the adjusted risk ratio for ADL decline among the participants with the most severe kyphosis was 2.6 (95% CI: 1.4–4.6). Assessments of kyphosis made with the Spinal Mouse also accurately predicted ADL decline. Conclusions: Visual assessment of kyphosis predicted future declines in ADL in this study. Since our method requires no special tools or training, it may be useful for identifying those at high risk of ADL decline.

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Association of blood pressure with estimates of 24-h urinary sodium and potassium excretion from repeated single-spot urine samples

Thi Minh Nguyen T., Miura K., Tanaka-Mizuno S., Tanaka T., Nakamura Y., Fujiyoshi A., Kadota A., Tamaki J., Takebayashi T., Okamura T., Ueshima H.

Hypertension Research （Hypertension Research）  42 （ 3 ） 411 - 418 2019年03月

ISSN  09169636

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© 2018, The Japanese Society of Hypertension. While the association between 24-h urinary sodium and potassium excretion with blood pressure is well established, the relationships of these ions to spot urine measurements are unclear. Our purpose is to assess the association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. Spot urine and blood pressure were collected annually during a 5-year period from 4360 Japanese workers with ages ranging from 19 to 55 years. Estimates of 24-h sodium and potassium excretion were based on Tanaka’s formula. Overall, a single standard deviation increase in the estimated sodium excretion (36.5 mmol/day) was associated with a 1.3 mmHg higher systolic blood pressure and a 0.8 mmHg higher diastolic blood pressure (P < 0.001). A single standard deviation increase in estimated potassium excretion (8.9 mmol/day) was associated with a 1.1 mmHg lower systolic blood pressure and a 0.7 mmHg lower diastolic blood pressure (P < 0.001). As a combined measure of the excretion of both electrolytes, the estimated 24-h sodium-to-potassium ratio was positively associated with both blood pressures (P < 0.001). Associations of blood pressure with sodium and the sodium-to-potassium ratio increased with age and were stronger in men compared to women. Associations with potassium and the sodium-to-potassium ratio were stronger in individuals who were overweight. The findings provide evidence for an association between blood pressure and the estimated 24-h sodium and potassium excretion from repeated single-spot urine samples. As convenient measures of dietary intake for each electrolyte, repeated spot urine samples may be useful for assessing hypertension risk, especially in men, older individuals, and overweight individuals.

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Does social interaction influence the effect of cognitive intervention program? A randomized controlled trial using Go game

Iizuka A., Suzuki H., Ogawa S., Kobayashi-Cuya K., Kobayashi M., Inagaki H., Sugiyama M., Awata S., Takebayashi T., Fujiwara Y.

International Journal of Geriatric Psychiatry （International Journal of Geriatric Psychiatry）  34 （ 2 ） 324 - 332 2019年02月

ISSN  08856230

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© 2018 The Authors. International Journal of Geriatric Psychiatry Published by John Wiley & Sons Ltd. Objectives: The purpose of this study is to clarify the influence of social interaction on the effect of a cognitive intervention program using Go. Methods: A single-blind, randomized controlled trial using a classical board game “Go” was conducted. A total of 72 community-dwelling older adults, without previous experience playing Go, were randomly assigned to three groups: (1) a face-to-face group (FG) in which members attended 12 Go group lessons held once a week; (2) a non-face-to-face group (NFG) in which members individually underwent the same Go lessons as the FG using a tablet computer; or (3) a health education control group (CG). The main outcome variable, working memory, was assessed before and after the interventions using the Visual Memory Span Test (VMST) and the Visual Memory Span Backward (VMSB) task. Go performance and additional cognitive domains were also examined. Results: Analysis of covariance revealed that VMST scores significantly improved after the intervention in both the FG and NFG (both P <.05). Compared with the CG, the effect size of the FG (Cohen's d = 0.89) was greater than that of the NFG (Cohen's d = 0.67). Although VMSB scores significantly improved after the intervention in the FG (P <.05), no significant changes were observed in other groups. Conclusions: This study showed that Go game could improve visual working memory regardless of social interaction. Furthermore, findings suggested that playing board games face-to-face with others is more effective for cognitive function than playing alone.

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Biological monitoring of o-toluidine in urine pretreated by an enzymatic deconjugation method

Eitaki Y., Nakano M., Kawai T., Omae K., Takebayashi T.

Journal of Occupational Health （Journal of Occupational Health）  2019年

ISSN  13419145

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© 2019 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health Objectives: To establish an enzymatic deconjugation method to separately quantify urinary o-toluidine (OT), its six metabolites, another six chemicals present in an OT-processing plant, and one metabolite of p-toluidine, and to propose optimal urinary biological monitoring items of OT exposure. Methods: Thirty-six urine samples of an OT-processing plant's workers were obtained and pretreated by an enzymatic deconjugation method employing β-glucuronidase/arylsulfatase for 3 hours at 37°C and measured by liquid chromatograph-mass spectrometry (LC-MS). An alkaline hydrolytic pretreatment and 1-chlorobutane extraction procedure was also examined as a widely used urinary OT measurement method. Results: The 14 chemicals were separated by LC-MS condition set by us and 13 chemicals other than 2-chloroaniline showed satisfiable linearity and limits of determination. Standard substances of six OT metabolites decomposed after the alkaline heating. In the 36 urine samples, OT, N-(4-hydroxy-2-methylphenyl) acetamide (NHM), and 4-amino-m-cresol (ACR) accounted for approx. 90% of the total OT and OT metabolites, but inter-individual variation of the three substance excretion seemed to be wide. Time course of urinary excretion revealed that concentration of the three substances was higher 24 hours after the work shift's end rather than just after the work shift. Conclusions: OT and its six metabolites can each be determined with LC-MS. The alkaline method is not so optimal for exact biological monitoring. Rather, the sum of urinary OT, NHM, and ACR measured by the enzymatic method is a better index, and "end of the workweek" is a good urine-sampling time for the biological monitoring of OT exposure.

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Clinical differences between elderly-onset ulcerative colitis and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan

Komoto S., Higashiyama M., Watanabe C., Suzuki Y., Watanabe M., Hibi T., Takebayashi T., Asakura K., Nishiwaki Y., Miura S., Hokari R.

Journal of Gastroenterology and Hepatology (Australia) （Journal of Gastroenterology and Hepatology (Australia)）  33 （ 11 ） 1839 - 1843 2018年11月

ISSN  08159319

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© 2018 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: Studies on the characteristics of elderly-onset ulcerative colitis (EOUC) and non-elderly-onset ulcerative colitis (NEOUC) have reported conflicting findings. The aim of this study was to compare disease characteristics of EOUC and NEOUC by analyzing the database of the Japanese nationwide inflammatory bowel disease (IBD) registry. Methods: We analyzed the age of disease onset, sex, disease severity, and disease extent in patients with ulcerative colitis that were newly diagnosed and registered within 1 year between 2004 and 2009 (n = 28 179). We also analyzed the medical treatment, rate of IBD-related surgery, and postoperative complications. We compared them between younger than 65 years old (NEOUC group) and 65 years old or older (EOUC group) patients. Results: A total of 25 401 (90.1%) and 2778 (9.9%) patients were included in the NEOUC and EOUC groups, respectively. In the EOUC group, disease activity was significantly higher, and extent of pathological changes in the colon more extended significantly. Laboratory findings showed that inflammatory markers were elevated significantly in the EOUC group. The proportion of those with IBD-related hospitalization was significantly higher in the EOUC group (54.2% vs 35.7%, P < 0.001). The proportion of patients who were treated with corticosteroids was significantly higher in the EOUC group (36.7% vs 30.8%, P < 0.001). Significantly more number of patients underwent IBD-related surgery in the EOUC group (0.68% vs 0.27%, P < 0.001). Conclusion: Elderly patients show higher disease activity, with a higher proportion requiring IBD-related hospitalization and IBD-related surgery, according to the nationwide registry in Japan.

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Hand dexterity, not handgrip strength, is associated with executive function in Japanese community-dwelling older adults: a cross-sectional study

武林 亨

BMC GERIATRICS 18 2018年08月

研究論文（学術雑誌）,  ISSN  1471-2318

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An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine

武林 亨

JOURNAL OF OCCUPATIONAL HEALTH 60 （ 4 ） 307 - 311 2018年07月

研究論文（学術雑誌）,  ISSN  1341-9145

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Falls and Physical Inactivity in Patients with Gastrointestinal Cancer and Hand-Foot Syndrome

Komatsu H., Yagasaki K., Hamamoto Y., Takebayashi T.

Asia-Pacific Journal of Oncology Nursing （Asia-Pacific Journal of Oncology Nursing）  5 （ 3 ） 307 - 313 2018年07月

ISSN  23475625

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© 2018 Medknow. All rights reserved. Objective: This study aims to ascertain the incidence and association of falls and physical inactivity in patients with gastrointestinal cancer and hand-foot syndrome (HFS) after receiving chemotherapy or targeted therapy. Methods: The present cross-sectional study was conducted on 50 outpatients with HFS of Grade 1 or above, according to the National Cancer Institute Common Terminology Criteria for Adverse Events, following the receipt of chemotherapy or targeted therapy for gastrointestinal cancer in Japan between November 2016 and February 2017. For measurement, Dermatology Life Quality Index (DLQI) and the International Physical Activity Questionnaire were used. Data were analyzed by logistic regression analysis. Results: Of the participants, 18% experienced falls and 60% reported physical inactivity. Multivariate logistic regression revealed that the DLQI treatment domain score was the only factor associated with falls (odds ratio [OR] =8.01, 95% confidence interval [CI] =1.27-50.63, P = 0.027). Physical inactivity was associated with DLQI symptom and feeling domain scores (OR = 5.54, 95% CI = 1.26-24.33, P = 0.023) and the with-oxaliplatin or paclitaxel regimen (OR = 3.71, 95% CI = 1.06-13.03, P = 0.041). Conclusions: The results of the present study suggest patients should be informed that HFS is a risk factor for physical inactivity and falls.

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Pilot Randomized Controlled Trial of the GO Game Intervention on Cognitive Function

武林 亨

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS 33 （ 3 ） 192 - 198 2018年05月

研究論文（学術雑誌）,  ISSN  1533-3175

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Association Between Knee Pain, Impaired Function, and Development of Depressive Symptoms

武林 亨

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 66 （ 3 ） 570 - 576 2018年03月

研究論文（学術雑誌）,  ISSN  0002-8614

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Community-wide physical activity intervention based on the Japanese physical activity guidelines for adults: A non-randomized controlled trial

武林 亨

PREVENTIVE MEDICINE 107   61 - 68 2018年02月

研究論文（学術雑誌）,  ISSN  0091-7435

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Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population

武林 亨

SCIENTIFIC REPORTS 8   61 - 68 2018年01月

研究論文（学術雑誌）,  ISSN  2045-2322

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Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

武林 亨

PLOS ONE 13 （ 1 ） 61 - 68 2018年01月

研究論文（学術雑誌）,  ISSN  1932-6203

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Carotid Plaque Score and Risk of Cardiovascular Mortality in the Oldest Old: Results from the TOOTH Study

武林 亨

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 25 （ 1 ） 55 - 64 2018年

研究論文（学術雑誌）,  ISSN  1340-3478

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Observational Evidence of the Association Between Handgrip Strength, Hand Dexterity, and Cognitive Performance in Community-Dwelling Older Adults: A Systematic Review

武林 亨

JOURNAL OF EPIDEMIOLOGY 28 （ 9 ） 373 - 381 2018年

研究論文（学術雑誌）,  ISSN  0917-5040

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Association of high individual-level of social capital with increased physical activity among community-dwelling elderly men and women: A cross-sectional study

Saito Y., Oguma Y., Tajima T., Kato R., Kibayashi Y., Miyachi M., Takebayashi T.

Japanese Journal of Physical Fitness and Sports Medicine （Japanese Journal of Physical Fitness and Sports Medicine）  67 （ 2 ） 177 - 185 2018年

ISSN  0039906X

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We aimed to evaluate the associations of individual-level social capital (SC) and physical activity (PA) among Japanese elderly men and women. Individuals aged 65 or above were selected via population-based random sampling of 3000 adults, aged 20 years or above and living in Fujisawa city, who were asked to complete self-administered questionnaires. The sample consisted of 260 men [median (25-75% tile) age 73 (68-78) yrs] and 274 women [73 (68-78) yrs]. The daily duration of PA, SC [e.g., norms of reciprocity (mutual support in the community), social networks (relationship with community people, exchange with other generations), social participation (participation in community organization activities)], socio-economic status [educational attainment, work with income, perceived household economic status], and demographic characteristics [sex, age, living arrangements, BMI, physical limitations] were assessed. Multivariate logistic regression analyses were used to calculate odds ratios (OR) for associations of SC with PA, stratified by sex. High level of mutual support in the community, relationship with community people, and exchange with other generations were associated with longer PA time in men after adjusting for potential confounders in the final model (OR = 2.40 (95% CI: 1.24-4.67), 5.28 (1.42-19.66), and 4.24 (1.15-15.67), respectively). In women, relationship with community people and participation in community organization activities were associated with longer PA time (3.10 (1.32-7.26) and 2.50 (1.27-4.91), respectively). The association of individual-level SC and PA differed between men and women. Future studies can investigate whether similar results can be obtained in other areas or attempt to conduct a large-scale survey.

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Needs survey on the priority given to periodical medical examination items among occupational physicians in Japan

Ito N., Nagata T., Tatemichi M., Takebayashi T., Mori K.

Journal of Occupational Health （Journal of Occupational Health）  60 （ 6 ） 502 - 514 2018年

ISSN  13419145

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© Article author(s). Objectives: To clarify the priority given to periodical medical examination items among occupational physicians in Japan. Methods: Sixty-two occupational physicians who participated in this study selected statutory and non-statutory items within two types of budget plans: one lower (8,500 yen) than the total fee of statutory medical examinations (9,250 and 11,290 yen), and the other higher (12,000 yen) than the total fee. Medical fee points were used to set the cost of each medical examination item. A three round Delphi method was used from May to July 2016 to clarify the consensus opinion of occupational physicians. Results: The statutory items (selection rate: between 66 and 100%), except for waist circumference (15%) and sputum examination (0%), and serum creatinine (58%, non-statutory item ) were included in the smaller budget plan (8,500 yen) . In the larger budget plan (12,000 yen), the statutory items (selection rate: between 92 and 100%), except for waist circumference (39%) and sputum examination (0%), and some non-statutory items, namely serum creatinine (95%), leukocytes (92%), uric acid (89%), and fecal occult blood reaction (81%), had a selection rate over 80%. In addition, statutory items with higher accuracy were preferred, which included the following: air conduction pure-tone audiometry (92%), imaging diagnosis of thoracic X-ray examinations by a specialist (97%), glycated hemoglobin levels (98%), and electrocardiogram assessment by a specialist (100%). Conclusion: The statutory items, except for waist circumference and sputum examination, and some of the non-statutory items (e.g., serum creatinine ) were given higher priority among occupational physicians in Japan.

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Relationship Between Depressive Symptoms and Activity of Daily Living Dependence in Older Japanese: The Kurabuchi Study

武林 亨

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 65 （ 12 ） 2639 - 2645 2017年12月

研究論文（学術雑誌）,  ISSN  0002-8614

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Effects of a school-based stroke education program on stroke-related knowledge and behaviour modification-school class based intervention study for elementary school students and parental guardians in a Japanese rural area

武林 亨

BMJ OPEN 7 （ 12 ） 61 - 68 2017年12月

研究論文（学術雑誌）,  ISSN  2044-6055

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Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study

武林 亨

CRITICAL CARE 21   55 - 64 2017年12月

研究論文（学術雑誌）,  ISSN  1466-609X

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