論文 - 武林　亨

The association of kyphosis assessed in supine and standing positions with future activities of daily living dependence: the Kurabuchi Study

武林 亨

ARCHIVES OF OSTEOPOROSIS 12 （ 1 ） 2639 - 2645 2017年11月

研究論文（学術雑誌）,  ISSN  1862-3522

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Influence of sulfur dioxide on the respiratory system of Miyakejima adult residents 6 years after returning to the island

武林 亨

JOURNAL OF OCCUPATIONAL HEALTH 59 （ 4 ） 313 - 326 2017年07月

研究論文（学術雑誌）,  ISSN  1341-9145

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Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant

武林 亨

JOURNAL OF OCCUPATIONAL HEALTH 59 （ 4 ） 364 - 366 2017年07月

研究論文（学術雑誌）,  ISSN  1341-9145

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Optimal plateau pressure for patients with acute respiratory distress syndrome: a protocol for a systematic review and meta-analysis with meta-regression

武林 亨

BMJ OPEN 7 （ 5 ） 313 - 326 2017年05月

研究論文（学術雑誌）,  ISSN  2044-6055

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Association Between Estimated 24-hour Urinary Sodium and Potassium Excretion and Blood Pressure in a Japanese Cohort: a Repeated Measure Analysis

武林 亨

CIRCULATION 135   187 - 193 2017年03月

研究論文（学術雑誌）,  ISSN  0009-7322

Changes of median nerve conduction velocity in rayon manufacturing workers: A 6-year cohort study

武林 亨

JOURNAL OF OCCUPATIONAL HEALTH 59 （ 2 ） 187 - 193 2017年03月

研究論文（学術雑誌）,  ISSN  1341-9145

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Changes of median nerve conduction velocity in rayon manufacturing workers: A 6-year cohort study

武林 亨

JOURNAL OF OCCUPATIONAL HEALTH 59 （ 2 ） 187 - 193 2017年03月

研究論文（学術雑誌）,  ISSN  1341-9145

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Identification of adverse events that have a negative impact on quality of life in a clinical trial comparing docetaxel versus S-1 with cisplatin in lung cancer

武林 亨

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY 21 （ 5 ） 836 - 842 2016年10月

研究論文（学術雑誌）,  ISSN  1341-9625

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Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

武林 亨

PLOS ONE 11 （ 10 ） 385 - 387 2016年10月

研究論文（学術雑誌）,  ISSN  1932-6203

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Relationships of Community and Individual Level Social Capital with Activities of Daily Living and Death by Gender

武林 亨

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 13 （ 9 ） 836 - 842 2016年09月

研究論文（学術雑誌）,  ISSN  1660-4601

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Profiling of plasma metabolites in postmenopausal women with metabolic syndrome

武林 亨

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 23 （ 7 ） 749 - 758 2016年07月

研究論文（学術雑誌）,  ISSN  1072-3714

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Occupational Exposure Limits of lead, dimethylamine, n-butyl-2,3-epoxypropyl ether, and 2-ethyl-1-hexanol and carcinogenicity and occupational sensitizer classification

武林 亨

JOURNAL OF OCCUPATIONAL HEALTH 58 （ 4 ） 385 - 387 2016年07月

研究論文（学術雑誌）,  ISSN  1341-9145

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Cross-sectional association between exposure to particulate matter and inflammatory markers in the Japanese general population: NIPPON DATA2010

武林 亨

ENVIRONMENTAL POLLUTION 213   460 - 467 2016年06月

研究論文（学術雑誌）,  ISSN  0269-7491

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A self-directed home yoga programme for women with breast cancer during chemotherapy: A feasibility study

武林 亨

INTERNATIONAL JOURNAL OF NURSING PRACTICE 22 （ 3 ） 258 - 266 2016年06月

研究論文（学術雑誌）,  ISSN  1322-7114

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Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study

武林 亨

AGE 38 （ 2 ） S265 - S265 2016年04月

研究論文（学術雑誌）,  ISSN  0161-9152

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Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia

武林 亨

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 31 （ 2 ） 334 - 341 2016年02月

研究論文（学術雑誌）,  ISSN  0815-9319

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Effects of processing and storage conditions on charged metabolomic profiles in blood

Hirayama Akiyoshi, Sugimoto Masahiro, Suzuki Asako, Hatakeyama Yoko, Enomoto Ayame, Harada Sei, Soga Tomoyoshi, Tomita Masaru, Takebayashi Toru

Electrophoresis 36 （ 18 ） 2148 - 2155 2015年09月

研究論文（学術雑誌）, 共著,  ISSN  0173-0835

　概要を見る

The development of high-throughput metabolite measurement technologies has enabled the use of metabolomics for epidemiologic studies by profiling metabolite concentrations in large cohorts of human blood samples. Standard protocols are necessary to obtain unbiased profiles through multiple runs over long periods of time and to allow reliable statistical analyses. This study assessed the effects of sampling procedures and storage conditions on the stability of metabolomic profiles in plasma and serum. Charged metabolomic profiles were determined by capillary electrophoresis-mass spectrometry (CE-MS) and compared by multivariate analyses. The effects of pre-analytical procedures, including times for clotting and incubation of serum and plasma, respectively; incubation temperatures; and number of freeze-thaw cycles, were assessed. Overall, inter-individual differences in profiles were larger than intra-individual differences, and profiles in plasma showed better stability than those in serum. These quantified datasets of metabolites, along with their stability and variation, may help in interpreting data from long-term cohort studies.</p>

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The effects of community-wide dissemination of information on perceptions of palliative care, knowledge about opioids, and sense of security among cancer patients, their families, and the general public

Akiyama Miki, Hirai Kei, Takebayashi Toru, Morita Tatsuya, Miyashita Mitsunori, Takeuchi Ayano, Yamagishi Akemi, Kinoshita Hiroya, Shirahige Yutaka, Eguchi Kenji

Supportive Care in Cancer 2015年06月

研究論文（学術雑誌）, 共著,  ISSN  0941-4355

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<p>Purpose: Prejudices against palliative care are a potential barrier to quality end-of-life care. There have been few large-scale community-wide interventions to distribute appropriate information about palliative care, and no studies have investigated their impact on cancer patients, their families, and the general public. Thus, we conducted a 3-year community intervention and evaluated the effects of distributing such information at the community level, and explored associations among levels of exposure, perceptions, knowledge, and the sense of security achieved. Methods: Over a period of 3 years, we provided flyers, booklets, posters, and public lectures about palliative care in four regions of Japan, and carried out pre- and post-intervention surveys with repeated cross-sectional samplings of cancer patients (pre 859, post 857), bereaved family members (1110, 1137), and the general public (3984, 1435). The levels of exposure to the provided information were measured by a multiple-choice questionnaire after intervention. Multiple logistic regression analyses were used to estimate multivariable-adjusted odds ratios (ORs) for perceptions of palliative care, knowledge about opioids, and sense of security among the exposure groups. Results: Overall perceptions of palliative care, opioids, and receiving care at home improved significantly among the general public and families, but not among the patients at the community level. However, multiple regression revealed that patients of extensive exposure category had significantly more positive perceptions of palliative care to those of non-exposure category (p = 0.02). The sense of security regarding cancer care of all patients, family members, and the general public improved. Among others, the respondents who reported extensive exposure in the general public and family members scored significantly higher sense of security. Conclusion: Our findings indicate that providing palliative care information via small media and lectures in the community is effective in improving perceptions of palliative care and knowledge about opioids among the community dwellers, especially for caregivers of the patients. The acquisition of adequate knowledge about palliative care from various information sources may improve people’s sense of security regarding cancer.</p>

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Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age

Arai Yasumichi, Martin-Ruiz Carmen M., Takayama Michiyo, Abe Yukiko, Takebayashi Toru, Koyasu Shigeo, Suematsu Makoto, Hirose Nobuyoshi, von Zglinicki Thomas

EBioMedicine 2015年06月

研究論文（学術雑誌）, 共著

　概要を見る

<p>To determine the most important drivers of successful ageing at extreme old age, we combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health (TOOTH), Tokyo Centenarians Study (TCS) and Japanese Semi-Supercentenarians Study (JSS) comprising 1554 individuals including 684 centenarians and (semi-)supercentenarians, 167 pairs of centenarian offspring and spouses, and 536 community-living very old (85 to 99years). We combined z scores from multiple biomarkers to describe haematopoiesis, inflammation, lipid and glucose metabolism, liver function, renal function, and cellular senescence domains. In Cox proportional hazard models, inflammation predicted all-cause mortality with hazard ratios (95% CI) 1.89 (1.21 to 2.95) and 1.36 (1.05 to 1.78) in the very old and (semi-)supercentenarians, respectively. In linear forward stepwise models, inflammation predicted capability (10.8% variance explained) and cognition (8&lt;sup&gt;.&lt;/sup&gt;6% variance explained) in (semi-)supercentenarians better than chronologic age or gender. The inflammation score was also lower in centenarian offspring compared to age-matched controls with δ (95% CI)=-0.795 (-1.436 to -0.154). Centenarians and their offspring were able to maintain long telomeres, but telomere length was not a predictor of successful ageing in centenarians and semi-supercentenarians. We conclude that inflammation is an important malleable driver of ageing up to extreme old age in humans.</p>

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Relationship of type of work with health-related quality of life

Kawabe Yuri, Nakamura Yasuyuki, Kikuchi Sayuri, Suzukamo Yoshimi, Murakami Yoshitaka, Tanaka Taichiro, Takebayashi Toru, Okayama Akira, Miura Katsuyuki, Okamura Tomonori, Fukuhara Shunichi, Ueshima Hirotsugu

Quality of Life Research 2015年06月

研究論文（学術雑誌）, 共著,  ISSN  0962-9343

　概要を見る

<p>Purpose: To examine the relation of work type with health-related quality of life (HRQoL) in healthy workers. Methods: We cross-sectionally examined 4427 (3605 men and 822 women) healthy workers in Japan, aged 19–69 years. We assessed HRQoL based on scores for five scales of the SF-36. Multiple regression was applied to examine the relation of work type (nighttime, shift, day to night, and daytime) with the five HRQoL norm-based scores, lower scores of which indicate poorer health status, adjusted for confounding factors, including sleeping duration. Results: Shiftwork was inversely related to role physical [regression estimate (β) = −2.12, 95 % confidence intervals (CI) −2.94, −1.30, P &lt; 0.001], general health (β = −1.37, 95 % CI −2.01, −0.72, P &lt; 0.001), role emotional (β = −1.24, 95% CI −1.98, −0.50, P &lt; 0.001), and mental health (β = −1.31, 95% CI −2.01, −0.63, P &lt; 0.001) independent of confounding factors, but not to vitality. Day-to-nighttime work was inversely related to all the five HRQoL subscales (Ps 0.012 to &lt;0.001). Conclusion: Shiftwork was significantly inversely related to four out of the five HRQoL, except for vitality, and day-to-nighttime work was significantly inversely related to all five HRQoL, independent of demographic and lifestyle factors.</p>

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