研究者詳細 - 武林　亨

論文 - 武林　亨

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Bronchoscopic microsampling to analyze the epithelial lining fluid of patients with pulmonary Mycobacterium avium complex disease

Nishimura Tomoyasu, Hasegawa Naoki, Watanabe Masazumi, Takebayashi Toru, Tasaka Sadatomo, Ishizaka Akitoshi

Respiration 76 （ 3 ） 338 - 343 2008年09月

研究論文（学術雑誌）, 共著, ISSN 0025-7931

Background: A new bronchoscopic microsampling (BMS) probe has recently been developed, which allows the minimally invasivecollection of epithelial lining fluid (ELF) simultaneously from multiple sites. While the number of immunocompetent patients with pulmonary Mycobacterium avium complex(MAC) disease is growing, the precise pathogenesis of the disease remains to be clarified. Objectives: This study aimed to measure biochemical markers in the ELF of patients with pulmonary MAC disease using BMS. Methods: We studied 8 healthy volunteers (controls) and 8 patients with pulmonary MAC disease. In the patients, ELF was collected from visibly abnormal (involved) and normal (uninvolved) sites using high-resolution computed tomography (HRCT). Results: The concentration of IFN-γ (means ± SEM) was significantly higher in patient ELF sampled from involved (26.62 ± 9.66 pg/ml) than from uninvolved sites (5.33 ± 1.44 pg/ml; p < 0.05) or from normal controls (<1.56 pg/ml; p < 0.05). In most patients, there was no difference in IFN-γ concentrations between the involved and uninvolved sites. The concentration of KL-6 in ELF was significantly higher in the involved (793 ± 108 U/ml) than in the uninvolved sites (192 ± 43 U/ml;p < 0.05) or in normal controls (186 ± 38 U/ml;p < 0.05). Conclusions: The specific inflammatory reaction caused by MAC infection might not be limited to sites that were visibly abnormal on HRCT. Although further improvement has to be considered, BMS may help to increase the understanding of the pathogenesis of various respiratory disorders. Copyright © 2008 S. Karger AG.

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[Iodine concentration in current Japanese foods and beverages].

Kikuchi Yuriko, Takebayashi Toru, Sasaki Satoshi

Nihon eiseigaku zasshi. Japanese journal of hygiene 63 （ 4 ） 724 - 734 2008年07月

研究論文（学術雑誌）, 共著

In the present study, we determined iodine concentration in commonly consumed foods in Japan. One hundred thirty-nine foods and beverages were purchased from local markets and convenience stores. These samples were examined for iodine concentration by using gas chromatography after ashing or extraction. The iodine concentrations in various food groups were as follows, The concentrations in cereals, sugar, sweeteners, vegetables, fruit, milk, and meat were too low to be detected (<0.05 mg/100 g). The iodine concentrations of algae and dashi (Japanese broth or stock) from algae were <0.05-225 mg/100 g; Japanese seasoning, <0.05-10.5 mg/100 g; and iodine-rich eggs, 1.09-2.00 mg/100 g. Food and beverages with high iodine concentrations need to be taken into account in the nutritional survey for health hazards and benefits in the evaluation of daily nutritional intake.

A survey on urinary incontinence among middle aged and older people

Michikawa Takehiro, Nishiwaki Yuji, Kikuchi Yuriko, Nakano Makiko, Takamizawa Megumu, Koike Mieko, Kikuchi Noriko, Mukoyami Yumi, Nakazawa Akemi, Nishigaki Yoshio, Takebayashi Toru

[Nippon kōshū eisei zasshi] Japanese journal of public health 55 （ 7 ） 449 - 455 2008年07月

研究論文（学術雑誌）, 共著, ISSN 0546-1766

OBJECTIVE: Studies in Western countries have revealed that urinary incontinence, non-intentional loss of urine, is a common condition in aged populations, and even younger individuals may suffer from urinary incontinence. However, in Japan, the evidence for community residents on this topic is limited. The aim of this study was to estimate the prevalence of urinary incontinence among middle aged using a structured questionnaire and older people and to provide useful information including frequency, voided volume, relation to parity as a risk factor and persons to consult for this condition. METHODS: The study subjects consisted of 985 residents, 350 males (mean age 62.5 +/- 11.2 years)and 635 females (64.3 +/- 11.4), who participated in annual health check-ups and answered a self-reported questionnaire on urinary incontinence. The questionnaire included questions on frequency, voided volume, condition-specific QOL score, self-diagnostic item (above four from Scored International Consultation on Incontinence Questionnaire-Short Form Japanese version), person to consult for this condition and parity (only for females). RESULTS: The proportion of those with urinary incontinence was 11.4% in males and 34.5% in females, and the proportion increased with age (P for trend <0.01). In females, the proportion was high, even in their forties (30.4%). In this study, parity was associated with urinary incontinence: compared to females with no childbirth experience, those giving birth to 4 or more children showed an odds ratio of 4.26 (95% CI: 1.13-16.10). In females, an increase in frequency of urinary incontinence negatively affected the QOL. When asked who they would consult, the majority of males answered either a medical institution (54.2%) or family (34.0%). In females, 39.6% reported a medical institution, 22.6% reported family, 16.5% reported no one, 10.6% reported health nurses other than in medical institutions and 9.5% reported friends. CONCLUSIONS: The study results showed that urinary incontinence is a common condition in this population. Particularly, a large proportion of females suffer from this condition, even in their forties. The study also revealed that urinary incontinence might negatively affect the QOL and that there are some individuals who do not consult (or intend to consult) anyone about their problem. This information might be useful for planning health policy on the topic in the future.

Marital status and cardiovascular risk factors among middle-aged Japanese male workers

Kamon Yuko, Okamura Tomonori, Tanaka Taichiro, Hozawa Atsushi, Yamagata Zentaro, Takebayashi Toru, Kusaka Yukinori, Urano Sumio, Nakagawa Hideaki, Kadowaki Takashi, Miyoshi Yuji, Yamato Hiroshi, Okayama Akira, Ueshima Hirotsugu

Journal of Occupational Health 50 （ 4 ） 348 - 356 2008年07月

研究論文（学術雑誌）, 共著, ISSN 1341-9145

Marital status is related to cardiovascular disease (CVD) risk factors in Western countries. However, few studies have addressed the relationship between marital status and CVD risk factors in other populations. We investigated lifestyle and CVD risk factors relative to marital status among middle-aged Japanese men. We analyzed baseline data of 40-59-yr-old male workers who participated in the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study. We compared lifestyle and CVD risk factors between men who were married (Group M; n=1,419, mean age 47.9 ±5.1 yr) and those who had never married (Group N; n=163, mean age 46.7 ±4.3 yr). Men in Group N were more likely to skip breakfast, work more shifts and exercise less. Current smoking rates, as well as average values of diastolic blood pressure (DBP), serum total cholesterol and fasting plasma glucose were also higher in Group N than in Group M. The proportion of participants with three or more CVD risk factors, namely smoking, hypertension, hypercholesterolemia and hyperglycemia was higher in Group N, than in Group M (12.9% vs. 5.0%, p<0.01). The difference between Groups M and N was more evident in the subgroup of living with others, than in the subgroup of living alone. Since men who have never married might be at higher risk for CVD, effort should be made to educate this population about decreasing lifestyle-related risk factors.

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Authors' reply

Takebayashi T., Akiba S., Kikuchi Y., Taki M., Wake K., Watanabe S., Yamaguchi Naohito

Occupational and Environmental Medicine 65 （ 6 ） 428 2008年06月

研究論文（学術雑誌）, 共著, ISSN 1351-0711

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Accuracy of an interferon-γ release assay to detect active pulmonary and extra-pulmonary tuberculosis

Nishimura T., Hasegawa Naoki, Mori M., Takebayashi T., Harada N., Higuchi K., Tasaka S., Ishizaka A.

International Journal of Tuberculosis and Lung Disease 12 （ 3 ） 269 - 274 2008年03月

研究論文（学術雑誌）, 共著, ISSN 1027-3719

OBJECTIVE: To examine the performance of an interferon-gamma (IFN-γ) release assay (QuantiFERON-TB 2G assay [QFT-G]) to detect Mycobacterium tuberculosis infection in a Japanese general hospital, for the diagnosis of active pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB). DESIGN: We prospectively examined the performance of QFT-G in 194 patients suspected of active TB. Diagnosis was confirmed by 1) positive M. tuberculosis cultures, or 2) clinical manifestations or laboratory or pathological findings consistent with active TB and response to specific therapy. RESULTS: Three patients with indeterminate QFT-G results were excluded. Among the remaining 191 patients, 77 had active TB. When the cut-off concentration of IFN-γ was set at 0.35 IU/ml, as recommended by the manufacturer, the assay was positive in 69 patients and negative in 122. The sensitivity of the assay was 76.6% in all patients, 74.5% in the 47 patients with PTB and 80.0% in the 30 patients with EPTB. The overall specificity of the assay was 91.2%. CONCLUSION: Although the specificity of the QFT-G to detect active TB was high and its sensitivity low, it was as accurate for the detection of active EPTB as for PTB when the 0.35 IU/ml INF-γ cut-off concentration was used. © 2008 The Union.

Mobile phone use, exposure to radiofrequency electromagnetic field, and brain tumour

Takebayashi T., Varsier N., Kikuchi Y., Wake K., Taki M., Watanabe S., Akiba S., Yamaguchi N.

British Journal of Cancer 98 （ 3 ） 652 - 659 2008年02月

研究論文（学術雑誌）, 共著, ISSN 0007-0920

In a case-control study in Japan of brain tumours in relation to mobile phone use, we used a novel approach for estimating the specific absorption rate (SAR) inside the tumour, taking account of spatial relationships between tumour localisation and intracranial radiofrequency distribution. Personal interviews were carried out with 88 patients with glioma, 132 with meningioma, and 102 with pituitary adenoma (322 cases in total), and with 683 individually matched controls. All maximal SAR values were below 0.1 W kg^-1, far lower than the level at which thermal effects may occur, the adjusted odds ratios (ORs) for regular mobile phone users being 1.22 (95% confidence interval (CI): 0.63-2.37) for glioma and 0.70 (0.42-1.16) for meningioma. When the maximal SAR value inside the tumour tissue was accounted for in the exposure indices, the overall OR was again not increased and there was no significant trend towards an increasing OR in relation to SAR-derived exposure indices. A non-significant increase in OR among glioma patients in the heavily exposed group may reflect recall bias. © 2008 Cancer Research UK.

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Job strain and arteriosclerosis in three different types of arteries among male Japanese factory workers

Michikawa Takehiro, Nishiwaki Yuji, Nomiyama Tetsuo, Uemura Takamoto, O'Uchi Toshihiro, Sakurai Haruhiko, Omae Kazuyuki, Takebayashi Toru

Scandinavian Journal of Work, Environment and Health 34 （ 1 ） 48 - 54 2008年02月

研究論文（学術雑誌）, 共著, ISSN 0355-3140

Objectives: This study evaluated the association between job strain and subclinical indicators of arteriosclerosis simultaneously in the cerebral artery, the aorta, and the carotid artery. Methods: The participants in this cross-sectional study consisted of 352 male factory workers between the ages of 24.9 to 55.8 (mean 41.7) years who had not been exposed to any hazardous chemicals in Japan. Job strain was measured using a Japanese version of the Job Content Questionnaire developed by Karasek. The following subclinical indicators of arteriosclerosis were examined by noninvasive procedures: hyperintense spots in T2-weighted images in brain magnetic resonance imaging (MRI), pulse wave velocity of the aorta, and the stiffness parameter of the carotid artery using ultrasound and systolic and diastolic blood pressure. Results: After control for potential confounders, high job strain was associated with an increased prevalence of hyperintense spots (adjusted odds ratio 2.53, 95% confidence interval 1.14-5.63), and elevated pulse-wave velocity (adjusted increase in percent 3.5, 95% confidence interval 0.0-6.9). The stiffness parameter tended to be elevated in the high job-strain group although this trend was not statistically significant. Job strain showed no relation to blood pressure. Conclusions: In this study, job strain was associated with subclinical indicators of arteriosclerosis in different arteries although the association was not statistically significant for the carotid artery. New information is offered by brain MRI for arteriosclerosis in the cerebral artery. An increase in hyperintense spots may explain the link between job strain and cerebrovascular disease.

Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage

Hamaguchi T., Omae K., Takebayashi T., Kikuchi Y., Yoshioka N., Nishiwaki Y., Tanaka A., Hirata M., Taguchi O., Chonan T.

Occupational and Environmental Medicine 65 （ 1 ） 51 - 55 2008年01月

研究論文（学術雑誌）, 共著, ISSN 1351-0711

Objectives: To identify the effects of indium on the lung and to assess exposure-effect and exposure-response relations between indium exposure and effects on the lungs. Methods: Ninety three male indium exposed and 93 male non-exposed workers from four ITO manufacturing or ITO recycling plants were analysed in a cross-sectional study. Indium in serum (In-S) was determined as a biological exposure index. Geometric means (GSD) of In-S were 8.25 ng/ml (4.55) in the exposed workers and 0.25 (2.64) in the non-exposed workers. The maximum concentration of In-S was 116.9 ng/ml. A questionnaire for respiratory symptoms and job histories, spirometry, high-resolution computerised tomography (HRCT) of the chest, serum KL-6, serum SP-A, serum SP-D and serum CRP were measured as the effect indices. Results: Spirometry, subjective symptoms and the prevalence of interstitial or emphysematous changes on lung HRCT showed no differences between exposed and non-exposed workers. Geometric means (GSD) of KL-6, SP-D and SP-A in the exposed workers were 495.4 U/ml (2.26), 85.2 ng/ml (2.02) and 39.6 ng/ml (1.57), and were significantly higher than those in the non-exposed workers. The prevalence (%) of the exposed and non-exposed workers exceeding the reference values were also significantly higher in KL-6 (41.9 vs 2.2), SP-D (39.8 vs 7.5), and SP-A (43.0 vs 24.7). Very sharp exposure-effect and exposure-response relations were discovered between In-S and KL-6 and between In-S and SP-D when the exposed workers were classified into seven groups by In-S. Conclusions: The study outcomes with regard to the basis of serum immunochemistry biomarkers and HRCT indicate that exposure to hardly soluble indium compound dust may represent a risk for interstitial lung damage.

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SAR characterization inside intracranial tumors for case-control epidemiological studies on cellular phones and RF exposure

Varsier Nadège, Wake Kanako, Taki Masao, Watanabe Soichi, Takebayashi Toru, Yamaguchi Naohito, Kikuchi Yuriko

annals of telecommunications - annales des télécommunications 1 - 14 2008年

研究論文（学術雑誌）, 共著, ISSN 0003-4347

Epidemiological studies investigating whether mobile phone use is related to cancer risk have been conducted in many countries. The purpose of the work reported here was to introduce the dose metric in the exposure assessment, taking into account the spatial distribution of exposure. Distributions of specific absorption rate (SAR) inside 275 cases of brain tumors (participants in the Japanese epidemiological study) were estimated. Phones had been classified into four categories based on SAR distributions and technical specifications. Results were found to be highly dependent on phone categories. Contralateral tumors were generally categorized as non-exposed tumors (max SAR <2.5% of max SAR in the brain) and, for any phone category, the maximum SAR in 75% of the ipsilateral tumors was less than 15% of the maximum SAR in the brain. Three new exposure indices combining the duration and strength of exposure were created to be used in the Japanese epidemiological study on mobile phone use and the risk of gliomas and meningiomas. © 2008 GET and Springer Verlag France.

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Standing body balance and fall related factors in community-dwelling elderly persons

Araya Kazufumi, Nishiwaki Yuji, Teragaki Yasuhiro, Kikuti Yuriko, Okamoto Michiko, Takebayashi Toru

Rigakuryoho Kagaku 23 （ 5 ） 597 - 600 2008年

研究論文（学術雑誌）, 共著, ISSN 1341-1667

[Purpose] The purpose of this research was to measure the functional reach (FR) value, as an index of standing balance ability, and to clarify its distribution among community dwelling elderly persons as well as its relationship with fall related factors, such as number of falls in the previous 1 year, history of fracture, and fear of falling. [Subjects] The subjects were 489 persons (226 males, 263 females) over the age of 65 living in K town, Gunma Prefecture, who gave their written consent at the time of their basic health check-up. [Methods] Using a reach measuring apparatus, we performed the FR test, and information regarding fall related factors was gathered by questionnaire. [Results] FR declined in both females and males with advancing age, and at 70 years of age, it had declined significantly in females, as compared to males. Regarding the relationship between FR and the number of falls, a significant decrease in FR was seen among females with 3 or more falls in the past 1 year in a comparison with those with no falls. However, no significant relationship was found between fracture history and fear of falling. [Conclusion] The correlation found between FR values and past number of falls suggests the possibility that FR can be used effectively in local public health programs aiming at fall prevention.

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The short treatment with the angiotensin receptor blocker candesartan surveyed by telemedicine (STAR CAST) study

Sasamura Hiroyuki, Nakaya Hideaki, Julius Stevo, Takebayashi Toru, Sato Yuji, Uno Hajime, Takeuchi Masahiro, Ishiguro Kimiko, Murakami Marohito, Ryuzaki Munekazu, Itoh Hiroshi

Hypertension Research 31 （ 10 ） 1843 - 1849 2008年

研究論文（学術雑誌）, 共著, ISSN 0916-9636

Previous studies have shown that transient treatment of animal models of hypertension with an angiotensin receptor blocker (ARB) causes a sustained decrease in blood pressure values that persists even after the drug treatment is discontinued (J Am Soc Nephrol 12: 659-666, 2001; Nephron 91: 710-718, 2002; Hypertens Res 30: 63-75, 2007). These results have been shown to be clinically relevant by the recent TROPHY study (N Engl J Med 354: 1685-1697, 2006). We have recently found that transient treatment with an ARB may also cause regression of established hypertension in hypertensive rats (J Am Soc Nephrol 18: 157A, 2007). The Short Treatment with the Angiotensin Receptor Blocker Candesartan Surveyed by Telemedicine (STAR CAST) study is a prospective, randomized, open, blinded end-point study in patients aged 30-59 with a positive family history of hypertension that will be conducted in several centers in Japan. The aim of the study is to evaluate the antihypertensive drug withdrawal success rate, the median duration of drug withdrawal, and the changes in home and office blood pressure values in patients with mild hypertension after tapering and withdrawal of antihypertensive treatment following treatment for 1 year with the ARB candesartan or the calcium channel blocker (CCB) nifedipine slow-release. A unique feature of this study is the use of a home blood pressure monitoring telemedicine system (i-TECHO) to allow frequent evaluation of the changes in blood pressure in the trial patients. This study will be the first clinical study to examine if regression from stage 1 (mild) hypertension to prehypertension (high-normal blood pressure) is possible using an ARB or CCB.

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Lactoferrin in Sjögren's Syndrome

Dogru Murat, Matsumoto Yukihiro, Yamamoto Yusuke, Goto Eiki, Saiki Megumi, Shimazaki Jun, Takebayashi Toru, Tsubota Kazuo

Ophthalmology 114 （ 12 ） 2007年12月

研究論文（学術雑誌）, 共著, ISSN 0161-6420

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Evaluation of the control banding method - Comparison with measurement-based comprehensive risk assessment

Hashimoto Haruo, Goto Toshiaki, Nakachi Nobutoyo, Suzuki Hidetaka, Takebayashi Toru, Kajiki Shigeyuki, Mori Koji

Journal of Occupational Health 49 （ 6 ） 482 - 492 2007年11月

研究論文（学術雑誌）, 共著, ISSN 1341-9145

The control banding method, or "control banding", is a simplified risk assessment system for chemical handling tasks. This system is supposed to provide assessment results of reasonable quality without expert involvement. The objective of this study was to evaluate the appropriateness of control banding judgment on the basis of workplace safety. A common approach for assessing workplace risk, which is called "comprehensive risk assessment" in this study, is to measure workers' exposure and compare it with relevant occupational exposure limits. Risk assessment was performed with control banding (COSHH Essentials, UK) at 12 workplaces of a petroleum company in Japan, where health risks had already been assessed separately through comprehensive risk assessment by experts and control technologies implemented accordingly. The obtained control banding judgments were then examined with regard to their adequacy by comparing them with existing control technologies. There was majority of cases (seven) where judgments by control banding were identified as "over-controlled"; there was no judgments identified as "under-controlled". Control banding also requested the seeking of expert advice in the majority of cases (eight). Thus, it was demonstrated that control banding tends to provide safe-sided judgment. A possible interpretation of this is that control banding is inherently designed to secure workplace safety by compensating for its insufficient exposure information with safe-sided judgment criteria and by requiring experts' intervention in high-risk cases. Control banding could be widely and effectively utilized in Japan, especially by employers in small enterprises, provided that the above characteristics are pre-acknowledged and health experts are made available. To this aim, it is essential to develop new local health experts and establish institutional mechanisms for facilitating employers' access to expert advice. It should however be noted that the number of workplaces evaluated in this study was small.

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Awareness and treatment of hypertension and hypercholesterolemia in Japanese workers

Tanaka Taichiro, Okamura Tomonori, Yamagata Zentaro, Takebayashi Toru, Tamura Unai, Kusaka Yukinori, Urano Sumio, Miyoshi Yuji, Okayama Akira, Ueshima Hirotsugu, Sakata Kiyomi, Tsuji Keiko, Yoshita Katsushi, Kikuchi Yuriko, Nakagawa Hideaki, Miura Katsuyuki, Yamato Hiroshi, Chiba Nagako, Yanagita Masahiko, Kodama Kazunori, Kasagi Fumiyoshi, Nishi Nobuo, Saitoh Shigeyuki, Tanaka Hideo, Nakamura Masakazu, Naito Yoshihiko, Nakamura Yasuyuki, Watanabe Makoto, Nakamura Yoshikazu, Babazono Akira, Yamagata Zentaro, Urano Sumio, Kinoshita Fujihisa, Saitoh Isao, Tanihara Shinichi, Tamaki Junko, Tochikubo Osamu, Nakayama Takeo, Fukuhara Shunichi, Fujieda Yoshiharu, Naito Mariko, Mizushima Shunsaku, Miyoshi Yuji, Tada Takayo, Kadowaki Takashi, Yoshida Toshimi, Ide Mami

Hypertension Research 30 （ 10 ） 921 - 928 2007年10月

研究論文（学術雑誌）, 共著, ISSN 0916-9636

The objective of this study was to clarify the awareness and treatment status of hypertension in Japanese workers, comparing with those of hypercholesterolemia. The subjects were 6,186 workers (age 19 to 69 years), who worked at 12 workplaces in Japan and who continuously participated in the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study at the baseline (1999 or 2000) and the subsequent year (2000 or 2001). No Intervention was performed during the study period. Blood pressure and total cholesterol level were measured at baseline. Awareness and treatment status were examined by a self-administered questionnaire in the following year. Untreated subjects were defined as those were not aware of hypertension (or hypercholesterolemia) or those not taking medication and not undergoing lifestyle modification. The percentages of subjects with hypertension defined as aware were 65.7% in men and 72.7% in women, respectively. The percentages of subjects with hypercholesterolemia defined as aware were 55.7% in men and 58.6% in women, respectively. In subjects 40 years and older, the awareness rate for hypertension was significantly higher than the awareness rate for hypercholesterolemia (75.0% vs. 59.2%, p<0.001). The percentage of untreated subjects with hypertension was significantly lower than the percentage of untreated subjects with hypercholesterolemia (41.0% vs. 57.1%, p<0.001). Although Japanese workers ≥40 years old have a higher awareness of and are more often treated for hypertension than for hypercholesterolernia, there are still many unaware and untreated individuals with either disease in all age groups. It is important to increase the awareness of risk factors in individuals with positive findings for these conditions.

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The INTERPHONE study: design, epidemiological methods, and description of the study population

Cardis Elisabeth, Richardson Lesley, Deltour Isabelle, Armstrong Bruce, Feychting Maria, Johansen Christoffer, Kilkenny Monique, McKinney Patricia, Modan Baruch, Sadetzki Siegal, Schuz Joachim, Swerdlow Anthony, Vrijheid Martine, Auvinen Anssi, Berg Gabriele, Blettner Maria, Bowman Joseph, Brown Julianne, Chetrit Angela, Christensen Helle Collatz, Cook Angus, Hepworth Sarah, Giles Graham, Hours Martine, Iavarone Ivano, Jarus-Hakak Avital, Klaeboe Lars, Krewski Daniel, Lagorio Susanna, Lonn Stefan, Mann Simon, McBride Mary, Muir Kenneth, Nadon Louise, Parent Marie-Elise, Pearce Neil, Salminen Tiina, Schoemaker Minouk, Schlehofer Brigitte, Siemiatycki Jack, Taki Masao, Takebayashi Toru, Tynes Tore, van Tongeren Martie, Vecchia Paolo, Wiart Joe, Woodward Alistair, Yamaguchi Naohito

European Journal of Epidemiology 22 （ 9 ） 647-664 2007年09月

研究論文（学術雑誌）, 共著, 査読有り

炎症性腸疾患の疫学

武林亨，朝倉敬子，西脇祐司

綜合臨床 56 （ 8 ） 2425-2428 2007年08月

研究論文（学術雑誌）, 共著, ISSN 0371-1900

女性の静止立位作業による血圧低下の実態調査

加部勇，鶴岡寛子，徳地谷洋子，遠藤裕一，古沢真実，武林亨

産業衛生学雑誌 49 （ 4 ） 122-126 2007年07月

研究論文（学術雑誌）, 共著, 査読有り

Investigation of postural hypotension due to static prolonged standing in female workers.

Kabe Isamu, Tsuruoka Hiroko, Tokujitani Yoko, Endo Yuichi, Furusawa Mami, Takebayashi Toru

Sangyō eiseigaku zasshi = Journal of occupational health 49 （ 4 ） 122 - 126 2007年07月

研究論文（学術雑誌）, 共著, ISSN 1341-0725

The "Just-in-Time system" improves productivity and efficiency through cost reduction while it makes workers work in a standing posture. The aim of this study was to investigate the prevalence of postural hypotension in females during prolonged standing work, and to discuss preventive methods. Twelve female static standing workers (mean age+/-standard deviation; 32+/-14 yr old), 6 male static standing workers (30+/-4 yr old), 10 female walking workers (27+/-7 yr old) and 9 female desk workers (31+/-5 yr old) in a certain telecommunications equipment manufacturing factory agreed to participate in this study. All participants received an interview with an occupational physician, and performed the standing up test before working and ambulatory blood pressure monitoring (ABPM) while working. Although the blood pressure of the standing up test did not differ among the groups, mean pulse rates on standing up significantly increased in every group. Hypotension rates in the female standing workers' group by ABPM were 9 persons of 12 participants (75%) for systolic blood pressure (SBP), and were 11 persons of 12 participants (92%) for diastolic blood pressure (DBP). There were significantly higher than those in the female desk workers' group, none of 9 participants (0%) for SBP and 2 of 9 participants (22%) for DBP. The hypotension rates both male standing and female walking worker groups did not differ. Because all 8 workers who were found to have postural hypotension by the standing up test had decreased SBP and/or DBP by ABPM, it is suggested that persons at high risk of postural hypotension during standing work could be screened by the standing up test. The mechanism of postural hypotension may be a decrease of venous return due to leg swelling, and neurocardiogenic or vasovagal response. Preventing the congestion of the lower limbs by walking, managing standing time and wearing elastic hose to keep the amount of the venous return could prevent postural hypotension during prolonged standing work.

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職域におけるポピュレーション・アプローチを用いた生活習慣病危険因子の改善（HIPOP-OHP研究）

岡村智教、田中太一郎、由田克士、武林亨、大和浩、三浦克之、中川秀昭、日下幸則、岡山明、山縣然太朗、上島弘嗣

産業医学ジャーナル 30 （ 2 ） 59-64 2007年03月

研究論文（学術雑誌）, 共著

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