Papers - Arita, Makoto

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut.

*Kunisawa J, *Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H.

Sci Rep 5   9750 2015

Research paper (scientific journal), Joint Work, Accepted

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Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: a potential alternative to immunosuppression.

*Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M

Intern Med 54   2377 - 2382 2015

Research paper (scientific journal), Joint Work, Accepted

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Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells.

Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, *Ueda K.

J Lipid Res 56   1880 - 1890 2015

Research paper (scientific journal), Joint Work, Accepted

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Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities.

Goto T, Urabe D, Masuda K, Isobe Y, Arita M, *Inoue M.

J Org Chem 80   7713 - 7726 2015

Research paper (scientific journal), Joint Work, Accepted

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Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis.

Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, *Furuta GT.

Gut 64   1236 - 1247 2015

Research paper (scientific journal), Joint Work, Accepted

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A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40/MEK-ERK pathway.

Miyamoto J, Mizukure T, Park S, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, *Tanabe S.

J Biol Chem 290   2902 - 2918 2015

Research paper (scientific journal), Joint Work, Accepted

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n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats.

*Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Inoue T, Hossain S, Arita M, Shido O.

Biochim Biophys Acta 1851   203 - 209 2015

Research paper (scientific journal), Joint Work, Accepted

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Combination therapy of 15-epi-lipoxin A4 with antibiotics protects mice from Escherichia coli-induced sepsis.

Ueda T, *Fukunaga K, Seki H, Miyata J, Arita M, Miyasho T, Obata T, Asano K, Betsuyaku T, Takeda J.

Crit Care Med 42   e288 - 295 2014

Research paper (scientific journal), Joint Work, Accepted

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The arachidonic acid metabolome as conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Lener D, Stanzl U, Seifert M, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Li X, Pallweber P, Scharnagl H, Stojakovic T, Marz W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, *Tancevski I.

Cell Metab 20   787 - 798 2014

Research paper (scientific journal), Joint Work, Accepted

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Immunomodulation with eicosapentaenoic acid supports the treatment of autoimmune small-vessel vasculitis.

*Hirahashi J, Kawahata K, Arita M, Iwamoto R, Hishikawa K, Honda M, Hamasaki Y, Tanaka M, Okubo K, Kurosawa M, Takase O, Nakakuki M, Saiga K, Suzuki K, Kawachi S, Tojo A, Seki G, Marumo T, Hayashi M, Fujita T.

Sci Rep 4   6406 2014

Research paper (scientific journal), Joint Work, Accepted

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A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques.

Iwaki S, Hokamura K, Ogawa M, Takehara Y, Muramatsu Y, Yamane T, Hirabayashi K, Morimoto Y, Hagisawa K, Nakahara K, Mineno T, Terai T, Komatsu T, Ueno T, Tamura K, Adachi Y, Hirata Y, Arita M, Arai H, Umemura K, Nagano T, *Hanaoka K.

Org Biomol Chem 12   8611 - 8618 2014

Research paper (scientific journal), Joint Work, Accepted

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18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling.

Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, *Arita M.

J Exp Med 211   1673 - 1687 2014

Research paper (scientific journal), Joint Work, Accepted

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Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite.

Yokokura Y, Isobe Y, Matsueda S, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H, *Arita M.

J Biochem 156   315 - 321 2014

Research paper (scientific journal), Joint Work, Accepted

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Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.

Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, *Arita M.

FASEB J 28   4036 - 4043 2014

Research paper (scientific journal), Joint Work, Accepted

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Rapidly rendering cells phagocytic through a cell-surface display technique and concurrent Rac activation.

Onuma H, *Komatsu T, Arita M, Hanaoka K, Ueno T, Terai T, Nagano T, *Inoue T.

Sci Signal 7   rs4 2014

Research paper (scientific journal), Joint Work, Accepted

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Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism.

*Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H.

J Immunol 193   1666 - 1671 2014

Research paper (scientific journal), Joint Work, Accepted

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Eicosapentaenoic acid is converted via omega-3 epoxygenation to anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid.

Kubota T, *Arita M, Isobe Y, Iwamoto R, Goto T, Yoshioka T, Urabe D, Inoue M, Arai H.

FASEB J 28   586 - 593 2014

Research paper (scientific journal), Joint Work, Accepted

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Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis.

Nakashima C, *Otsuka A, Kitoh A, Honda T, Egawa G, Nakajima S, Nakamizo S, Arita M, Kubo M, Miyachi Y, *Kabashima K.

J Allergy Clin Immunol 134   100 - 107 2014

Research paper (scientific journal), Joint Work, Accepted

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Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyusaturated fatty acids in vitro and in vivo.

Taguchi A, *Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, kang JX, Arai H, *Arita M, Osuga Y, Fujii T.

PLoS One 27   e89605 2014

Research paper (scientific journal), Joint Work, Accepted

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Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model.

Katakura M, *Hashimoto M, Inoue T, Al Mamun A, Tanabe Y, Iwamoto R, Arita M, Tsuchikura S, Shido O.

Molecules 19   3247 - 3263 2014

Research paper (scientific journal), Joint Work, Accepted

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