Papers - Arita, Makoto

An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis.

Li J, Chen CY, Arita M, Kim K, Li X, Zhang H, *Kang JX.

Carcinogenesis (Carcinogenesis)  39 ( 11 ) 1380 - 1388 2018

Research paper (scientific journal), Joint Work, Accepted

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Melanoma has a high propensity to metastasize and exhibits a poor response to classical therapies. Dysregulation of the chemokine receptor gene CXCR4 is associated with melanoma progression, and although n-3 polyunsaturated fatty acids (PUFAs) are known to be beneficial for melanoma prevention, the underlying mechanism of this effect is unclear. Here, we used the n-3 fatty acid desaturase (Fat-1) transgenic mouse model of endogenous n-3 PUFA synthesis to investigate the influence of elevated n-3 PUFA levels in a mouse model of metastatic melanoma. We found that relative to wild-type (WT) mice, Fat-1 mice exhibited fewer pulmonary metastatic colonies and improved inflammatory indices, including reduced serum tumor necrosis factor alpha (TNF-α) levels and pulmonary myeloperoxidase activity. Differential PUFA metabolites in serum were considered a key factor to alter cancer cell travelling to lung, and we found that n-6 PUFAs such as arachidonic acid induced CXCR4 protein expression although n-3 PUFAs such as eicosapentaenoic acid (EPA) decreased CXCR4 levels. In addition, serum levels of the bioactive EPA metabolite, 18-HEPE, were elevated in Fat-1 mice relative to WT mice, and 18-HEPE suppressed CXCR4 expression in B16-F0 cells. Moreover, relative to controls, numbers of pulmonary metastatic colonies were reduced in WT mice receiving intravenous injections either of 18-HEPE or 18-HEPE-pretreated melanoma cells. Our results indicate that 18-HEPE is a potential anticancer metabolite that mediates, at least in part, the preventive effect of n-3 PUFA on melanoma metastasis.

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PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, Arita M, Akiyama M, *Murakami M.

Nature Commun 8   14609 2017

Research paper (scientific journal), Joint Work, Accepted

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Comprehensive identification of sphingolipid species by in silico retention time and tandem mass spectral library.

Tsugawa H, Ikeda K, Tanaka W, Senoo Y, *Arita M, *Arita M

J Cheminform 9   19 2017

Research paper (scientific journal), Joint Work, Accepted

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Prolonged activation of IL-5 producing ILC2 causes pulmonary arterial hypertrophy.

Ikutani M, Tsuneyama K, Kawaguchi K, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, *Takatsu K.

JCI Insight 2   e90721 2017

Research paper (scientific journal), Joint Work, Accepted

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Gut microbiota promotes obesity-associated liver cancer through PGE2-mediated suppression of antitumor immunity.

Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Iwama A, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo M, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, *Ohtani N.

Cancer Discov 7   522 - 538 2017

Research paper (scientific journal), Joint Work, Accepted

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Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.

Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, Hirota Y, Fujii T, Tsuchiya S, Taketomi Y, Sugimoto Y, Murakami M, Arita M, Kurano M, Ikeda H, Yatomi Y, Chun J, *Aoki J.

EMBO J 36   2146 - 2160 2017

Research paper (scientific journal), Joint Work, Accepted

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Therapeutic effects of flurbiprofen axetil on mesenteric traction syndrome: randomized clinical trial.

Takahashi H, Shida D, Tagawa K, Iwamoto R, Arita M, Arai H, Suzuki T.

BMC Surg 17   90 2017

Research paper (scientific journal), Joint Work, Accepted

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Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library.

Aoyagi R, Ikeda K, Isobe Y, *Arita M

J Lipid Res 58   2229 - 2237 2017

Research paper (scientific journal), Joint Work, Accepted

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ω3 fatty acid epoxides are autocrine mediators that ensure full activation of mast cells.

Shimanaka Y, Kono N, Taketomi Y, Arita M, Okayama Y, Tanaka Y, Nishito Y, Mochizuki T, Kusuhara H, Adibekian A, Cravatt BF, *Murakami M, *Arai H.

Nat Med 23   1287 - 1297 2017

Research paper (scientific journal), Joint Work, Accepted

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Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.

Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, Dodo K, Terayama N, Sodeoka M, Aoyagi R, Arita M, Arakawa S, Shimizu S, *Tanaka M.

Sci Rep 7   16026 2017

Research paper (scientific journal), Joint Work, Accepted

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Maternal dietary balance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.

Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, *Osumi N.

Stem Cells 34   470 - 482 2016

Research paper (scientific journal), Joint Work, Accepted

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Heterogenous fibroblasts underlie age-dependent tertially lymphoid tissues in the kidney.

Sato Y, Mii A, Hamazaki Y, Fujita H, Nakata H, Masuda K, Nishiyama S, Shibuya S, Haga H, Ogawa O, Shimizu A, Narumiya S, Kaisho T, Arita M, Yanagisawa M, Miyasaka M, Sharma K, Minato N, Kawamoto H, *Yanagita M.

JCI Insight １   e87680 2016

Research paper (scientific journal), Joint Work, Accepted

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Chronic arachidonic acid administration decreases docosahexaenoic acid and eicosapentaenoic acid-derived metabolites in kidneys of aged rats.

Katakura M, *Hashimoto M, Inoue T, Mamun AA, Tanabe Y, Arita M, Shido O.

PLoS One 10   e0140884 2015

Research paper (scientific journal), Joint Work, Accepted

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Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.

Sawada Y, *Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, *Kabashima K.

J Exp Med 212   1921 - 1930 2015

Research paper (scientific journal), Joint Work, Accepted

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Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut.

*Kunisawa J, *Arita M, Hayasaka T, Harada T, Iwamoto R, Nagasawa R, Shikata S, Nagatake T, Suzuki H, Hashimoto E, Kurashima Y, Suzuki Y, Arai H, Setou M, Kiyono H.

Sci Rep 5   9750 2015

Research paper (scientific journal), Joint Work, Accepted

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Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: a potential alternative to immunosuppression.

*Hirahashi J, Hanafusa N, Wada T, Arita M, Hishikawa K, Hayashi M, Nangaku M

Intern Med 54   2377 - 2382 2015

Research paper (scientific journal), Joint Work, Accepted

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Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells.

Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, *Ueda K.

J Lipid Res 56   1880 - 1890 2015

Research paper (scientific journal), Joint Work, Accepted

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Total synthesis of four stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-dihydroxy-4,7,10,12,16,18-docosahexaenoic acid and their anti-inflammatory activities.

Goto T, Urabe D, Masuda K, Isobe Y, Arita M, *Inoue M.

J Org Chem 80   7713 - 7726 2015

Research paper (scientific journal), Joint Work, Accepted

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Eosinophil-mediated signaling attenuates inflammatory responses in experimental colitis.

Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, *Furuta GT.

Gut 64   1236 - 1247 2015

Research paper (scientific journal), Joint Work, Accepted

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A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40/MEK-ERK pathway.

Miyamoto J, Mizukure T, Park S, Kishino S, Kimura I, Hirano K, Bergamo P, Rossi M, Suzuki T, Arita M, Ogawa J, *Tanabe S.

J Biol Chem 290   2902 - 2918 2015

Research paper (scientific journal), Joint Work, Accepted

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