Details of a Researcher - Torii, Hidemasa

Papers - Torii, Hidemasa

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Myopia prevention device

K Tsubota, K Negishi, H Torii, T Kurihara

US Patent 10,133,092 2018

Lead author, Last author, Corresponding author

Violet Light Transmission is Related to Myopia Progression in Adult High Myopia

Torii Hidemasa, Ohnuma Kazuhiko, Kurihara Toshihide, Tsubota Kazuo, Negishi Kazuno

Scientific Reports (Scientific Reports) 7 ( 1 ) 2017.12

ISSN 2045-2322

Myopia is increasing worldwide. Although the exact etiology of myopia is unknown, outdoor activity is one of the most important environmental factors for myopia control. We previously reported that violet light (VL, 360-400 nm wavelength), which is abundant in the outdoor environment, suppressed myopia progression for individuals under 20 years of age. However, whether VL is also effective for adult high myopia, which can be sight-threatening, has remained unknown. To investigate the influence of VL for adult myopia, we retrospectively compared the myopic progression and the axial length elongation over five years in adult high myopic patients over 25 years of age after two types (non-VL transmitting and VL transmitting) of phakic intraocular lens (pIOL) implantation. We found that high myopic patients with the non-VL transmitting pIOLs implanted are almost two times more myopic in the change of refraction and four times longer in the change of axial length, compared to those implanted with the VL transmitting pIOLs. This result indicated that the VL transmitting pIOL suppressed myopia progression and axial length elongation compared with the non-VL transmitting one. In conclusion, our study showed the VL possibly has an anti-myopia effect for human adults with high myopia.

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特集近視の進行をコントロールする 6.屋外環境とのかかわり

鳥居秀成, 栗原俊英, 坪田一男

眼科 (金原出版) 59 ( 9 ) 897 - 903 2017.09

Lead author, Last author, Corresponding author, ISSN 00164488

A dose dependent myopic shift in refraction and axial length in a murine model of lens-induced myopia

X Jiang, K Mori, Y Tanaka, S Ikeda, M Miyauchi, E Yotsukura, H Torii, ...

Investigative Ophthalmology & Visual Science 58 (8), 4438-4438 58 ( 8 ) 2017.06

Lead author, Last author, Corresponding author, ISSN 0146-0404

Morphological changes of scleral fibroblasts in a murine lens-induced myopia model

S Ikeda, T Kurihara, X Jiang, Y Tanaka, K Mori, M Miyauchi, H Torii, ...

Investigative Ophthalmology & Visual Science 58 (8), 1115-1115 58 ( 8 ) 2017.06

Lead author, Last author, Corresponding author, ISSN 0146-0404

Transient exposure of high concentration oxygen induces sustained myopia in adult mice

K Mori, T Kurihara, X Jiang, E Yotsukura, Y Tanaka, S Ikeda, M Miyauchi, ...

Investigative Ophthalmology & Visual Science 58 (8), 5471-5471 58 ( 8 ) 2017.06

Lead author, Last author, Corresponding author, ISSN 0146-0404

Comparative analysis of the visual and refractive outcomes of a refractive segmented multifocal intraocular lens with and without toricity: 1-year results

R Shodai, K Negishi, H Arai, I Toda, H Torii, K Tsubota

Japanese journal of ophthalmology 61, 142-149 (Japanese Journal of Ophthalmology) 61 ( 2 ) 142 - 149 2017.03

Lead author, Last author, Corresponding author, ISSN 00215155

Purpose: To compare the visual and refractive outcomes up to 1 year postoperatively following implantation of a refractive segmented or a refractive segmented toric multifocal intraocular lens (IOL). Methods: This retrospective study included 108 eyes of 64 patients who underwent cataract surgery with implantation of a refractive segmented multifocal IOL (Lentis Mplus LS-313 MF30 IOL) (LM group) and 81 eyes of 49 patients with implantation of a refractive segmented toric multifocal IOL (Lentis Mplus LU-313 MF30T IOL) (LMT group). The visual and refractive postoperative outcomes and the rate of additional refractive procedures were evaluated up to 1 year postoperatively. Results: The uncorrected distance visual acuity (VA) and uncorrected near VA exceeded 1.0 and 0.60 in decimal VA, respectively, and both were stable postoperative groups. The postoperative subjective refractive astigmatism was also stable and the postoperative refraction was near emmetropia in both groups. No significant differences were found in the need for additional surgical refractive procedures. Conclusion: The outcomes with a refractive segmented toric multifocal IOL were comparable to those with a non-toric model despite higher preoperative corneal astigmatism.

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分節状屈折型多焦点眼内レンズの視力成績と屈折成績のトーリックレンズ使用の有無による比較分析　1年間の成績(Comparative analysis of the visual and refractive outcomes of a refractive segmented multifocal intraocular lens with and without toricity: 1-year results)

Shodai Ryo, Negishi Kazuno, Arai Hiroyuki, Toda Ikuko, Torii Hidemasa, Tsubota Kazuo

Japanese Journal of Ophthalmology (シュプリンガー・ジャパン(株)) 61 ( 2 ) 142 - 149 2017.03

Lead author, Last author, Corresponding author, ISSN 0021-5155

白内障手術を施行された患者のうち、屈折分節型多焦点眼内レンズ(IOL)移植術を受けた64名108眼(LM群)と屈折分節型トーリック多焦点IOL移植術を受けた49名81眼の成績を1年後まで比較した。小数視力(VA)における裸眼遠見VAは1.0、裸眼近見VAは0.6を超えており、両方とも術後安定していた。術後の主観的屈折乱視も安定しており、術後の屈折は両群ともほぼ正常視であった。外科的屈折矯正処置を追加する必要性には有意差は認められなかった。以上より、分節状屈折型トーリック多焦点IOL施行患者は術前の角膜乱視の程度が高かったにもかかわらず、その成績は非トーリックモデルの成績と同等であった。

Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

Torii Hidemasa, Kurihara Toshihide, Seko Yuko, Negishi Kazuno, Ohnuma Kazuhiko, Inaba Takaaki, Kawashima Motoko, Jiang Xiaoyan, Kondo Shinichiro, Miyauchi Maki, Miwa Yukihiro, Katada Yusaku, Mori Kiwako, Kato Keiichi, Tsubota Kinya, Goto Hiroshi, Oda Mayumi, Hatori Megumi, Tsubota Kazuo

EBioMedicine (EBioMedicine) 15 210 - 219 2017.02

ISSN 2352-3964

Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400 nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.

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Comparative analysis of the visual and refractive outcomes of a refractive segmented multifocal intraocular lens with and without toricity

Shodai Ryo, Negishi Kazuno, Arai Hiroyuki, Toda Ikuko, Torii Hidemasa, Tsubota Kazuo

Japanese Journal of Ophthalmology 1 - 8 2017.01

ISSN 0021-5155

Purpose: To compare the visual and refractive outcomes up to 1 year postoperatively following implantation of a refractive segmented or a refractive segmented toric multifocal intraocular lens (IOL). Methods: This retrospective study included 108 eyes of 64 patients who underwent cataract surgery with implantation of a refractive segmented multifocal IOL (Lentis Mplus LS-313 MF30 IOL) (LM group) and 81 eyes of 49 patients with implantation of a refractive segmented toric multifocal IOL (Lentis Mplus LU-313 MF30T IOL) (LMT group). The visual and refractive postoperative outcomes and the rate of additional refractive procedures were evaluated up to 1 year postoperatively. Results: The uncorrected distance visual acuity (VA) and uncorrected near VA exceeded 1.0 and 0.60 in decimal VA, respectively, and both were stable postoperative groups. The postoperative subjective refractive astigmatism was also stable and the postoperative refraction was near emmetropia in both groups. No significant differences were found in the need for additional surgical refractive procedures. Conclusion: The outcomes with a refractive segmented toric multifocal IOL were comparable to those with a non-toric model despite higher preoperative corneal astigmatism.

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子どもとメディアの問題を考える 5.「子どもとメディア」視機能への影響

H TORII, K TSUBOTA

日本小児科医会会報, 29-33 2017

Lead author, Last author, Corresponding author

CLINICAL INVESTIGATION: Comparative analysis of the visual and refractive outcomes of a refractive segmented multifocal intraocular lens with and without toricity: 1-year results

R Shodai, K Negishi, H Arai, I Toda, H Torii, K Tsubota

Japanese journal of ophthalmology: the official international journal of the … 2017

Lead author, Last author, Corresponding author

Decreased sleep quality in high myopia children

Ayaki Masahiko, Torii Hidemasa, Tsubota Kazuo, Negishi Kazuno

Scientific Reports (Scientific Reports) 6 2016.09

ISSN 2045-2322

The aim of the present study was to evaluate sleep quality in myopic children and adults. This cross sectional study surveyed 486 participants aged from 10 to 59 years with refractive errors using a questionnaire containing the Pittsburgh Sleep Quality Index (PSQI) and Hospital Anxiety and Depression Scale (HADS). Children (< 20 years) in the high myopia group exhibited the poorest PSQI scores (P < 0.01), while the adults showed no such correlations. Subscales of PSQI and HADS in children disclosed that the high myopia groups had the shortest sleep duration (P < 0.01), worst subjective sleep scores (P < 0.001), and latest bedtime (P < 0.05). Regression analyses in children significantly correlated myopic errors with PSQI (P < 0.05), sleep duration (P < 0.01), and bedtime (P < 0.01). Sleep efficacy (P < 0.05) and daytime dysfunction (P < 0.05) were significantly better in contact-lens users compared to the respective non-user groups across all participants. In conclusion, sleep quality in children was significantly correlated with myopic error, with the high myopia group worst affected.

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Yotsukura Erisa, Negishi Kazuno, Torii Hidemasa, Saiki Megumi, Tsubota Kazuo

Journal of Cataract and Refractive Surgery 42 ( 9 ) 1392 - 1393 2016.09

ISSN 0886-3350

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治療的表層角膜切除眼の白内障手術に対する眼内レンズ度数計算式の精度の比較(Comparison of the accuracy of intraocular lens power calculations for cataract surgery in eyes after phototherapeutic keratectomy)

Yaguchi Yukari, Negishi Kazuno, Saiki Megumi, Torii Hidemasa, Tsubota Kazuo

Japanese Journal of Ophthalmology (シュプリンガー・ジャパン(株)) 60 ( 5 ) 365 - 372 2016.09

Lead author, Last author, Corresponding author, ISSN 0021-5155

治療的表層角膜切除術(PTK)後に白内障手術を施行した13名(平均年齢68.8歳)23眼を対象として、近視矯正手術後の眼内レンズ(IOL)度数計算に用いられる幾つかの計算式の精度を白内障手術後のIOL度数計算に用い、計算式の精度を後ろ向きに比較した。予測誤差を術後等価球面屈折率推定値と眼鏡平面における術後に示された屈折率との差として定義し、SRK/T、Haigis-L、Shammas-PL、Camellin-Calossi、OKU-LIX ray tracingソフトウェアの5つの式を用いた。5つの式の算術予測誤差と絶対予測誤差の中央値を比較した。白内障手術後の算術誤差中央値はSRK/Tが0.70ジオプター(D)、Haigis-Lが-0.96D、Shammas-PLが-0.81D、Camellin-Calossiが-0.04D、OKU-LIXが0.68Dであった。PTK施行眼におけるIOL度数計算にはCamellin-Calossiが最も有用な選択肢であると考えられた。

Effects of ultra violet radiation on serum vitamin d levels in chick experimental myopia models

K Mori, T Kurihara, X Jiang, M Miyauchi, Y Katada, Y Miwa, Y Seko, ...

Investigative Ophthalmology & Visual Science 57 (12), 5522-5522 57 ( 12 ) 2016.09

Lead author, Last author, Corresponding author, ISSN 0146-0404

An effective and robust murine lens-induced myopia model evaluated with micro-CT imaging

T Kurihara, X Jiang, K Tsubota, K Mori, Y Miwa, Y Katada, M Miyauchi, ...

Investigative Ophthalmology & Visual Science 57 (12), 5746-5746 57 ( 12 ) 2016.09

Lead author, Last author, Corresponding author, ISSN 0146-0404

Age, eye dominance, and phoria cause errors in measurement of objective refractions

Y Tsuneyoshi, H Torii, Y Nishi, Y Hidaka, S Masui, K Tsubota, K Negishi

Investigative Ophthalmology & Visual Science 57 (12), 6238-6238 57 ( 12 ) 2016.09

Lead author, Last author, Corresponding author, ISSN 0146-0404

Establishment of retinal ganglion cell-specific gene recombination murine models using tet system

Y Katada, M Miyauchi, Y Miwa, X Jiang, K Mori, H Torii, KF Tanaka, ...

Investigative Ophthalmology & Visual Science 57 (12), 747-747 57 ( 12 ) 2016.09

Lead author, Last author, Corresponding author, ISSN 0146-0404

Suppressive effect of metformin against experimental myopia in chick

H Torii, T Kurihara, X Jiang, Y Katada, Y Miwa, K Mori, M Miyauchi, ...

Investigative Ophthalmology & Visual Science 57 (12), 5520-5520 57 ( 12 ) 2016.09

Lead author, Last author, Corresponding author, ISSN 0146-0404

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