Papers - Torii, Hidemasa

Corrigendum to Ratio of Axial Length to Corneal Radius in Japanese Patients and Accuracy of Intraocular Lens Power Calculation Based on Biometric Data. Am J Ophthalmol 2020 …

MK Omoto, H Torii, K Hayashi, M Ayaki, K Tsubota, K Negishi

American Journal of Ophthalmology 231, 210  2021

Lead author, Last author, Corresponding author

Association between Axial Length of the Eye and Length of Each Part of the Body

A Shinojima, T Kurihara, K Mori, Y Iwai, A Hanyuda, K Negishi, H Torii, ...

 2021

Lead author, Last author, Corresponding author

Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics

T Kurihara, D Lee, A Shinojima, T Kinoshita, S Nishizaki, Y Arita, Y Hidaka, ...

PloS one 16 (9), e0256986 (PLoS ONE)  16 ( 9 ) e0256986 2021

Lead author, Last author, Corresponding author,  ISSN  1932-6203

　View Summary

Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a noninvasive blood glucose monitoring site. However, calculating blood glucose levels from measuring glucose levels in AC has been difficult and unclear. In this study, we aimed to examine glucose levels from AC and find a correlation with blood glucose levels. A total of 30 patients with cataracts (men and women, study 1; 7 and 3, study 2; 9 and 11) who visited Keio University Hospital from 2015 to 2018 and agreed to participate in this study were recruited. Glucose levels from AC and the blood were examined by a UV-hexokinase or H2O2-electrode method before/during the cataract surgery. These values were analyzed with regression analyses depending on the groups (blood glucose-ascending and descending groups). In the blood glucose-descending group, glucose levels from AC were strongly correlated with blood glucose levels (a high R2 value, 0.8636). However, the relatively moderate correlation was seen in the blood glucose-ascending group (a low R2 value, 0.5228). Taken together, we showed different correlation ratios on glucose levels between AC and the blood, based on blood glucose dynamics. Stacking data regarding this issue would enable establishing noninvasive blood glucose monitoring from measuring glucose levels in AC more correctly, which will be helpful for proper and prompt managements for glucose-mediated complications.

• Access to Document (DOI)

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

X Jiang, MT Pardue, K Mori, S Ikeda, H Torii, S D’Souza, RA Lang, ...

Proceedings of the National Academy of Sciences 118 (22), e2018840118  2021

Lead author, Last author, Corresponding author

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

T Kurihara, X Jiang, M Pardue, K Mori, S Ikeda, H Torii, S D’Souza, ...

Investigative Ophthalmology & Visual Science 62 (8), 2277-2277  2021

Lead author, Last author, Corresponding author

RATIO OF AXIAL LENGTH TO CORNEAL RADIUS IN JAPANESE PATIENTS AND ACCURACY OF INTRAOCULAR LENS POWER CALCULATION BASED ON BIOMETRIC DATA (vol 218, pg 320, 2020)

MK Omoto, H Torii, K Hayashi, M Ayaki, K Tsubota, K Negishi

AMERICAN JOURNAL OF OPHTHALMOLOGY 231  2021

Lead author, Last author, Corresponding author

Multi-Functionality of Eyes: Visual and Non-Visual Roles

K Tsubota, H Torii, T Kurihara

Brain and Nerve= Shinkei Kenkyu no Shinpo 73 (11), 1185-1191  2021

Lead author, Last author, Corresponding author

Light source for myopia prevention article and method of using light source for myopia prevention article

M Yamakawa, H Torii, T Kurihara, K Tsubota

US Patent App. 17/301,859  2021

Lead author, Last author, Corresponding author

Light source for myopia prevention article and method of using light source for myopia prevention article

M Yamakawa, H Torii, T Kurihara, K Tsubota

US Patent 11,007,375  2021

Lead author, Last author, Corresponding author

Axial length and prevalence of myopia among schoolchildren in the equatorial region of Brazil

E Yotsukura, H Torii, H Ozawa, RY Hida, T Shiraishi, I Corso Teixeira, ...

Journal of Clinical Medicine 10 (1), 115 (Journal of Clinical Medicine)  10 ( 1 ) 1 - 11 2020.12

Lead author, Last author, Corresponding author,  ISSN  2077-0383

　View Summary

The prevalence of myopia is increasing globally, and the outdoor light environment is considered as a possible factor that can retard myopia. The aim of this study was to evaluate the prevalence of myopia and the light environment in Aracati, equatorial Brazil. We surveyed 421 children (421 right eyes; mean age, 10.6 years) and performed ocular examinations that in- cluded non-cycloplegic refraction and axial length (AL). Multiple regression analyses were performed to identify factors affecting myopia such as time spent outdoors and in near work. We measured illuminance and violet light irradiance in Aracati. The mean spherical equivalent (SE) and AL were-0.44 ± 1.38 diopters (D) and 22.98 ± 0.87 mm, respectively. The prevalence of myopia (SE≤-0.75 D) and high myopia (SE ≤-6.0 D/AL≥26.0 mm) was 20.4 and 1.4/0.48%, respectively. Multiple regression analyses showed that myopia was not associated with lifestyle factors. The average illuminance in Aracati was about 100,000 lux from morning to evening. The current results reflect the ALs and the prevalence of myopia among Brazilian schoolchildren. There is a possibility that the light environment in addition to other confounding factors including racial differences affects the ALs and refractive errors.

• Access to Document (DOI)

Oral bovine milk lactoferrin administration suppressed myopia development through matrix metalloproteinase 2 in a mouse model

SI Ikeda, T Kurihara, M Toda, X Jiang, H Torii, K Tsubota

Nutrients 12 (12), 3744 (Nutrients)  12 ( 12 ) 1 - 9 2020.12

Lead author, Last author, Corresponding author

　View Summary

Recent studies have reported an association between myopia development and local ocular inflammation. Lactoferrin (LF) is an iron-binding protein present in saliva, tears, and mother’s milk. Furthermore, sequestering iron by LF can cause its antibacterial property. Moreover, LF has an anti-inflammatory effect. We aimed to determine the suppressive effect of LF against the development and progress of myopia using a murine lens-induced myopia (LIM) model. We divided male C57BL/6J mice (3 weeks old) into two groups. While the experimental group was orally administered LF (1600 mg/kg/day, from 3-weeks-old to 7-weeks-old), a similar volume of Ringer’s solution was administered to the control group. We subjected the 4-week-old mice to −30 diopter lenses and no lenses on the right and left eyes, respectively. We measured the refraction and the axial length at baseline and 3 weeks after using a refractometer and a spectral domain optical coherence tomography (SD-OCT) system in both eyes. Furthermore, we determined the matrix metalloproteinase-2 (MMP-2) activity, and the amount of interleukin-6 (IL-6), MMP-2, and collagen 1A1 in the choroid or sclera. The eyes with a minus lens showed a refractive error shift and an axial length elongation in the control group, thus indicating the successful induction of myopia. However, there were no significant differences in the aforementioned parameters in the LF group. While LIM increased IL-6 expression and MMP-2 activity, it decreased collagen 1A1 content. However, orally administered LF reversed these effects. Thus, oral administration of LF suppressed lens-induced myopia development by modifying the extracellular matrix remodeling through the IL-6–MMP-2 axis in mice.

• Access to Document (DOI)

Axial length shortening in a myopic child with anisometropic amblyopia after wearing violet light-transmitting eyeglasses for 2 years

Y Ofuji, H Torii, E Yotsukura, K Mori, T Kurihara, K Negishi, K Tsubota

American Journal of Ophthalmology Case Reports 20, 101002 (American Journal of Ophthalmology Case Reports)  20   101002 2020.12

Lead author, Last author, Corresponding author,  ISSN  24519936

　View Summary

Purpose: To report a case in which the axial length (AL) shortened and the choroid thickened due to the use of violet light-transmitting eyeglasses. Observations: A 4-year-old boy with high myopia was referred to Keio University Hospital. He was prescribed standard eyeglasses. Six months after the first visit, his best-corrected visual acuities were 1.2 and 0.4 in the right and left eyes, respectively, with the standard eyeglasses, and he was diagnosed with anisometropic amblyopia. The right eye then was patched for 6 hours daily during the daytime. Because of the availability of violet light-transmitting eyeglasses, we changed the eyeglasses and instructed his parents to have him engage in outdoor activities for over 2 hours daily to be exposed to sufficient violet light. As a result, the violet light entered his left eye and minimal violet light entered his right eye. The changes in the ALs, choroidal thicknesses, and cycloplegic objective refractions in the right and left eyes during 2 years of wearing violet light-transmitting eyeglasses were +0.85 and −0.20 mm, +4.9 and + 115.7 μm, and −1.02 and + 1.88 D, respectively. Conclusions and importance: We successfully described a case in which the myopia improved, the AL shortened, and the choroid thickened after using violet light-transmitting eyeglasses.

• Access to Document (DOI)

Subjective happiness and satisfaction in postoperative anisometropic patients after refractive surgery for myopia

K Negishi, I Toda, M Ayaki, H Torii, K Tsubota

Journal of Clinical Medicine 9 (11), 3473 (Journal of Clinical Medicine)  9 ( 11 ) 1 - 11 2020.10

Lead author, Last author, Corresponding author,  ISSN  2077-0383

　View Summary

Laser-assisted in situ keratomileusis (LASIK) contributes to increased patient happiness one month after surgery; however, longer term effects are unknown. We performed a retrospective cross-sectional study on 472 patients who underwent bilateral LASIK surgery to measure happiness and satisfaction with LASIK, and to identify affecting factors. Patients completed questionnaires on satisfaction with the surgery and the subjective happiness scale (SHS) before, and 1, 3, 6, and 12 months after surgery. Multiple regression analyses were performed to determine independent predictors of SHS and satisfaction scores. Mean SHS increased at one month but was similar to baseline levels by six months. The SHS of older patients was greater than younger ones at baseline and at one and three months, while satisfaction among the older group was poorer at one and three months. Multiple regression analyses revealed that the decrease in SHS score from one month to three months correlated with baseline SHS, SHS at one month, uncorrected distance visual acuity (UDVA), and age. Regression analysis revealed SHS at six months correlated with preoperative SHS, SHS at one month, and satisfaction at six months. Satisfaction at final visit correlated with age, UDVA, anisometropia, and with SHS at each visit. We conclude that happiness and satisfaction were age-and UDVA-dependent, and anisometropic patients report poorer satisfaction scores.

• Access to Document (DOI)

Changes in Patient Subjective Happiness and Satisfaction with Cataract Surgery

Yotsukura Erisa, M Ayaki, N Nezu, H Torii, H Arai, K Sakatani, K Tsubota, K Negishi

The Journal of The Japanese Society for Cataract Research (The Japanese Society for Cataract Research)  10 ( 1 ) 17273 - 83 2020.10

Lead author, Last author, Corresponding author,  ISSN  09154302

　View Summary

The purpose of this study was to investigate the changes in patient subjective happiness and satisfaction with cataract surgery and evaluate the association between satisfaction and types of cataract. This study surveyed 247 participants (mean age, 67.9 years) and they completed questionnaires on their satisfaction with the surgery, the subjective happiness scale (SHS) and the Pittsburgh Sleep Quality Index (PSQI) before and after surgery. The SHS increased postoperatively from 4.6 ± 0.7 to 4.8 ± 0.7 (P = 0.007) and 83.4% of patients were satisfied with the surgical results and the average satisfaction score was 4.2 out of a possible 5.0. Multiple regression analysis showed that patient satisfaction was significantly associated with the postoperative SHS (β = 0.380; P < 0.001), the postoperative PSQI (β = −0.041; P = 0.035) and the presence of a posterior subcapsular cataract (PSC) (β = 0.277; P = 0.026). This study clarified that cataract surgery may improve both visual function and patient happiness and that patient satisfaction was affected by postoperative sleep quality and the disappearance of a PSC.

• Access to Document (DOI)
• CiNii Research

Author Correction: Ocular biometry and refractive outcomes using two swept-source optical coherence tomography-based biometers with segmental or equivalent refractive indices.

Omoto MK, Torii H, Masui S, Ayaki M, Tsubota K, Negishi K

Scientific reports (Scientific Reports)  10 ( 1 ) 13181 2020.07

Lead author, Last author, Corresponding author

　View Summary

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

• Access to Document (DOI)

Five-year outcomes of corneal cross-linking for Keratoconus: comparison between conventional and accelerated procedures

N Kato, K Negishi, C Sakai, I Toda, T Ide, H Torii, K Tsubota

Cornea 39 (1), e1 (Cornea)  39 ( 1 ) e1 - e2 2020.01

Lead author, Last author, Corresponding author,  ISSN  0277-3740

• Access to Document (DOI)

Ratio of axial length to corneal radius in Japanese patients and accuracy of intraocular lens power calculation based on biometric data

MK Omoto, H Torii, K Hayashi, M Ayaki, K Tsubota, K Negishi

American Journal of Ophthalmology 218, 320-329 (American Journal of Ophthalmology)  218   320 - 329 2020

ISSN  00029394

　View Summary

© 2020 The Authors Purpose: To evaluate the features of the axial length-to-corneal radius (AL/CR) ratio in Japanese patients with cataracts and to determine the accuracy of intraocular lens (IOL) power calculation formulas according to the AL/CR features and the axial length (AL). Design: Retrospective observational case series. Methods: Setting was a clinical practice. Patient population was a total of 1,135 eyes (1,135 patients) with cataracts. Observation procedures included measurement of the AL and corenal radius (CR) by optical biometry and evaluation of the refractive outcomes by using the SRK/T, Holladay 1, Hoffer Q, Haigis, and Barrett Universal II formulas. Main outcome measurements were the features of the AL/CR ratio and the accuracy of IOL power calculations based on the AL/CR ratio and the AL. Results: The mean AL/CR ratio was 3.15 ± 0.19. Significant weak negative correlations were observed between the spherical equivalent (SE) and AL (r = −0.7489; P < .001) and between the SE and AL/CR ratio (r = −0.8069; P < .001); no correlation was found between the SE and CR (r = 0.0208, P = .483). For medium ALs and high AL/CR ratios, the SRK/T formula performed less accurately. For long ALs and high AL/CR ratios, the Holladay 1 and Hoffer Q formulas performed less accurately. The Barrett Universal II formula performed well across a range of ALs and AL/CR ratios. Conclusions: The AL/CR ratio explained the total variation in the SE better than the AL alone. Surgeons should pay attention to the selection of IOL power calculation formulas in eyes with high AL/CR ratios.

• Access to Document (DOI)

Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice

Mori K., Kurihara T., Jiang X., Ikeda S.I., Yotsukura E., Torii H., Tsubota K.

Nutrients (Nutrients)  12 ( 1 )  2020

　View Summary

© 2020, MDPI AG. All rights reserved. The natural carotenoid crocetin has been reported to suppress phenotypes of an experimental myopia model in mice. We investigated the minimum effective dose to prevent myopia progression in a murine model. Three-week-old male mice (C57B6/J) were equipped with a −30 diopter (D) lens to induce myopia, and fed with normal chow, 0.0003%, or 0.001% of crocetin-containing chow. Changes in refractive errors and axial lengths (AL) were evaluated after three weeks. Pharmacokinetics of crocetin in the plasma and the eyeballs of mice was evaluated with specific high sensitivity quantitative analysis using liquid chromatography tandem mass spectrometry (LC-MS/MS) to determine the minimum effective dosage. A concentration of 0.001% of crocetin-containing chow showed a significant (p < 0.001) suppressive effect against both refractive and AL changes in the murine model. Meanwhile, there was no significant difference of AL change between the 0.0003% and the normal chow groups. The concentration of crocetin in the plasma and the eyeballs from mice fed with 0.001% crocetin-containing chow was significantly higher than control and 0.0003% crocetin-containing chow. In conclusion, we suggest 0.001% of crocetin-containing extract is the minimum effective dose showing a significant suppressive effect against both refractive and AL changes in the murine model.

• Access to Document (DOI)

Accuracy of Intraocular Lens Power Calculation Formulas in Eyes after Laser in Situ Keratomileusis

T Suzuki, H Torii, Y Nishi, K Tsubota, K Negishi

2020 ASCRS Annual Meeting  2020

Lead author, Last author, Corresponding author

Centrifugal Pump

H Torii, K Nakaya

US Patent App. 16/763,241  2020

Lead author, Last author, Corresponding author