Papers - Torii, Hidemasa

Wavelength Specificity of Violet Light on Suppressing Refractive Change and Axial Elongation in A Murine Model of Lens-induced Myopia

X Jiang, T Kurihara, K Mori, S Ikeda, H Torii, K Tsubota

Investigative Ophthalmology & Visual Science 60 (9), 3153-3153 60 ( 9 )  2019.07

Lead author, Last author, Corresponding author,  ISSN  0146-0404

Comparison of the accuracy of newer intraocular lens power calculation methods in eyes that underwent previous phototherapeutic keratectomy

Y Yagi-Yaguchi, K Negishi, M Saiki, H Torii, K Tsubota

Journal of Refractive Surgery 35 (5), 310-316 (Journal of Refractive Surgery)  35 ( 5 ) 310 - 316 2019.05

ISSN  1081597X

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Copyright © SLACK Incorporated. PURPOSE: To evaluate the accuracy of intraocular lens (IOL) power calculations using ray tracing software in patients who had undergone phototherapeutic keratectomy (PTK). METHODS: In this retrospective case series, 37 eyes of 22 patients (mean age: 69.4 years; range: 56 to 85 years) who underwent cataract surgery after PTK were reviewed. The prediction error, defined as the difference between the estimated postoperative spherical equivalent and the postoperative manifest refraction at the spectacle plane, was calculated using the following formulas: OKULIX (Tedics, Dortmund, Germany), PhacoOptics (IOL Innovations ApS, Aarhus, Denmark), Barrett True K No History (NH), and Camellin-Calossi. The PhacoOptics formula was used in three different ways: historical method (H), no history method (NH), and C-constant method (C). The median values of the arithmetic and absolute prediction errors among these six IOL calculation methods were compared. RESULTS: The median arithmetic errors (in diopters [D]) and percentages of eyes within ±0.50 D of the absolute errors were as follows: OKULIX (0.33, range: -2.20 to 2.50, 30.6%), PhacoOptics (H) (-0.12, range: -3.28 to 4.85, 22.2%), PhacoOptics (NH) (-0.25, range: -2.08 to 1.70, 48.4%), PhacoOptics (C) (0.04, range: -1.40 to 2.18, 48.5%), Barrett True K (NH) (-0.35, range: -1.90 to 1.89, 48.6%), and Camellin-Calossi (-0.19, range: -1.78 to 1.47, 59.5%). CONCLUSIONS: The PhacoOptics, especially the C-constant method (C), and Camellin-Calossi formulas were good options for calculating IOL powers in eyes that underwent PTK.

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IMI–Clinical myopia control trials and instrumentation report

JS Wolffsohn, PS Kollbaum, DA Berntsen, DA Atchison, A Benavente, ...

Investigative ophthalmology & visual science 60 (3), M132-M160 (Investigative Ophthalmology and Visual Science)  60 ( 3 ) M132 - M160 2019.02

ISSN  01460404

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© 2019 The Authors. The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes were classified as primary (refractive error and/or axial length), secondary (patient reported outcomes and treatment compliance), and exploratory (peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/ lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently available instrumentation, which the literature has shown to best achieve the primary and secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient selection were also identified. These findings and consensus from the International Myopia Institute members led to final recommendations to inform future instrumentation development and to guide clinical trial protocols.

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Inducement and evaluation of a murine model of experimental myopia

X Jiang, T Kurihara, S Ikeda, H Kunimi, K Mori, H Torii, K Tsubota

JoVE (Journal of Visualized Experiments), e58822 (Journal of Visualized Experiments)  2019 ( 143 )  2019.01

ISSN  1940087X

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© 2019 Journal of Visualized Experiments. Murine model of myopia can be a powerful tool for myopia research because of the comparatively easy genetic manipulation. One way to induce myopia in animals is to put clear minus lenses in front of eyes for weeks (lens-induced myopia, LIM). However, extant protocols for inducement and evaluation vary from laboratory to laboratory. Here, we described a highly practical and reproducible method to induce LIM in mice using newly designed eyeglasses. The method fixes the lens stably in front of the mouse eye while allows the lens to be taken off for cleaning or topical drug administration. The phenotype is robust and efficient, and the variance is small. The method described here can be applied to mice right after weaning which extends the possible duration for experiments. We also gave technical advises for achieving reproducible results in refraction and axial length measurements. We hope the step-by-step protocol described here and the detailed article can help researchers perform myopia experiments with myopia more smoothly and make the data comparable across laboratories.

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Dietary Supplement Crocetin Has a Suppressive Effect Against Myopia Progression: A Randomized Clinical Trial

K Mori, H Torii, S Fujimoto, X Jiang, S Ikeda, E Yotsukura, S Koh, ...

Available at SSRN 3384857  2019

Lead author, Last author, Corresponding author

IMI Clinical Myopia Control Trials and Instrumentation Report

DAA Berntsen, A Benavente, A Bradley, H Buckhurst, M Collins, ...

 2019

Lead author, Last author, Corresponding author

Violet Light Can be a Protective Factor Against Myopia Progression?

Torii Hidemasa

The Journal of The Japanese Society for Cataract Research (The Japanese Society for Cataract Research)  31 ( 1 ) 43 - 46 2019

Lead author, Last author, Corresponding author,  ISSN  09154302

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A highly efficient murine model of experimental myopia

Jiang Xiaoyan, Kurihara Toshihide, Kunimi Hiromitsu, Miyauchi Maki, Ikeda Shin Ichi, Mori Kiwako, Tsubota Kinya, Torii Hidemasa, Tsubota Kazuo

Scientific Reports (Scientific Reports)  8 ( 1 )  2018.12

ISSN  2045-2322

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<p>Despite the global pandemic of myopia, the precise molecular mechanism of the onset of myopia remains largely unknown. This is partially because of the lack of efficient murine myopic models that allow genetic manipulation at low cost. Here we report a highly practical and reproducible lens-induced myopia model by specially designed frames and lenses for mice. A lens power dependent myopic induction in mice was shown until minus 30 diopter lenses. The phenotype was significantly stronger than form-deprivation myopia. We presented the protocol for precise evaluations of the state of myopia, including refraction, corneal curvature and axial length using up-to-date devices. We also found that myopic mouse eyes showed decreased visual acuity on optokinetic response examination. Finally, we confirmed the anti-myopic effect of 1% atropine using this model, which showed its potential in drug screening. The strong phenotype, stable evaluation and the potential for gene manipulation utilizing the presented method in mice will accelerate the translational research of myopia.</p>

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Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial

H Kanda, T Oshika, T Hiraoka, S Hasebe, K Ohno-Matsui, S Ishiko, ...

Japanese journal of ophthalmology 62, 537-543 (Japanese Journal of Ophthalmology)  62 ( 5 ) 537 - 543 2018.09

ISSN  00215155

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© 2018, Japanese Ophthalmological Society. Purpose: Novel spectacle lenses (MyoVision, Carl Zeiss) designed to reduce relative peripheral hyperopia have been developed and reported to be effective for preventing myopia progression in a subgroup of Chinese children. In this study we examined the efficacy of MyoVision lenses in Japanese children. Study design: This was a multicenter prospective randomized double-blind placebo-controlled trial. Method: We enrolled 207 participants (aged 6–12 years) with spherical equivalent refractions (SERs) ranging from −1.5 to −4.5 diopters (D) and with at least 1 myopic parent. The participants were randomized to receive either single vision lenses (SVLs) or MyoVision lenses and were followed up every 6 months for 2 years. The primary outcome was myopia progression evaluated by cycloplegic autorefraction, and the secondary outcome was elongation of axial length. Results: A total of 203 children (98.1%) completed the follow-up. The mean adjusted change in SER was −1.43 ± 0.10 D in the MyoVision group, which was not significantly different from that of the control group wearing SVLs (−1.39 ± 0.07 D) at the 24-month visit (P =.65). The adjusted axial length elongation was 0.73 ± 0.04 mm in the MyoVision group, which was not significantly different from that in the control group wearing SVLs (0.69 ± 0.03 mm) at the 24-month visit (P =.28). Conclusion: The results of this clinical trial could not verify the therapeutic effect of MyoVision for slowing down myopia progression in Japanese children. Additional studies are needed to design lenses that can reduce peripheral hyperopic defocus individually and to examine the effectiveness of these lenses in preventing myopia progression.

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日本人小児の近視進行に対する相対的周辺部遠視(relative peripheral hyperopia)を軽減するために設計された眼鏡用レンズの影響　2年間の多施設共同無作為化比較試験(Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized controlled trial)

Kanda Hiroyuki, Oshika Tetsuro, Hiraoka Takahiro, Hasebe Satoshi, Ohno-Matsui Kyoko, Ishiko Satoshi, Hieda Osamu, Torii Hidemasa, Varnas Saulius R., Fujikado Takashi

Japanese Journal of Ophthalmology (シュプリンガー・ジャパン(株))  62 ( 5 ) 537 - 543 2018.09

Lead author, Last author, Corresponding author,  ISSN  0021-5155

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小児の近視進行予防における軸外収差抑制レンズであるMyoVisionの有効性を調査した。両側近視で等価球面屈折度数(SER)が-1.50～-4.50Dであり、親が近視である小児207例(女児57%、平均9.67±1.44歳)を対象とした。単焦点レンズ(SVL)群105例とMyoVisionレンズ群102例に無作為に分け、2年の経過観察期間中、6ヵ月毎に調節麻痺下オートリフレクションによって近視進行を評価し、眼軸長を測定した。2年後のSERにおける平均補正変化はMyoVision群が-1.43±0.10Dで、SVL群の-1.39±0.07Dと有意差がなかった。眼軸長の2年後の平均補正伸長はMyoVision群が0.73±0.04mmで、SVL群の0.69±0.03mmと有意差がなかった。SVLの使用と比較して、MyoVisionレンズの使用で近視進行の比率に有意差が観察されなかった。

Correlations between age and ocular aberrations in school children

YVBL Rautha, RY Hida, C Nascimento, L Hida, K Tsubota, H Torii, ...

Investigative Ophthalmology & Visual Science 59 (9), 4769-4769 59 ( 9 )  2018.07

Lead author, Last author, Corresponding author,  ISSN  0146-0404

The relationship between violet light transmittance of contact lenses and axial length elongation

H Torii, T Kurihara, S Kondo, X Jiang, K Mori, S Ikeda, E Yotsukura, ...

Investigative Ophthalmology & Visual Science 59 (9), 2145-2145 59 ( 9 )  2018.07

Lead author, Last author, Corresponding author,  ISSN  0146-0404

Violet light exposure suppresses refractive change and axial elongation in a murine model of lens-induced myopia

T Kurihara, X Jiang, K Mori, S Ikeda, H Torii, K Tsubota

Investigative Ophthalmology & Visual Science 59 (9), 677-677 59 ( 9 )  2018.07

Lead author, Last author, Corresponding author,  ISSN  0146-0404

Progress and control of myopia by light environments

X Jiang, T Kurihara, H Torii, K Tsubota

Eye & contact lens 44 (5), 273-278 (Eye and Contact Lens)  44 ( 5 ) 273 - 278 2018

ISSN  15422321

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Copyright © 2018 Contact Lens Association of Ophthalmologists, Inc. Unauthorized reproduction of this article is prohibited. During the past 30 years, the prevalence rate of myopia has been increased dramatically. Myopia has become one of the leading causes of vision loss in some countries, whereas the mechanism of the main pathological change in myopia is still largely unknown. Although several studies showed genetic background influences the phenotype of myopia to some extent, the sudden increase of morbidity cannot be explained by genetics only. The change in lifestyle results in tremendous change in the light environment, which can be considered to play an important role in the onset and progression of myopia. The difference between indoor and outdoor light environments such as intensity and wavelength of modern electronic lighting equipment may be a cue for myopia control as environmental factors. In this review, we discuss the relationship between myopia and light environment focusing on the basic and clinical studies.

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CLINICAL INVESTIGATION: Effect of spectacle lenses designed to reduce relative peripheral hyperopia on myopia progression in Japanese children: a 2-year multicenter randomized …

H Kanda, T Oshika, T Hiraoka, S Hasebe, K Ohno-Matsui, S Ishiko, ...

Japanese journal of ophthalmology: the official international journal of the …  2018

Lead author, Last author, Corresponding author

Electric pump

H Torii

US Patent 10,030,661  2018

Lead author, Last author, Corresponding author

Irradiation device

K Tsubota, K Negishi, H Torii, T Kurihara

US Patent App. 15/996,842  2018

Lead author, Last author, Corresponding author

Wavelength-selective transparent glass product

H Hirakoso, T Mashimo, K Nagai, K Tsubota, T Kurihara, H Torii

US Patent App. 15/992,408  2018

Lead author, Last author, Corresponding author

Vortex pump and fuel vapor treatment device comprising the vortex pump

H Torii, A Sugimoto, S Suzuki

US Patent 10,041,501  2018

Lead author, Last author, Corresponding author

Violet Light as a Superhero Against Myopia Pandemic

H Torii

2018 ASCRS ASOA Annual Meeting  2018

Lead author, Last author, Corresponding author