Papers - Hashiguchi, Akinori

MGUS(Monoclonal gammopathy of undetermined significance)(IgMκ)が原因の二次性Fanconi症候群にIgA腎症が合併した一例

田島 敬也, 脇野 修, 中谷 英章, 徳山 博文, 橋口 明典, 小西 孝之助, 伊藤 裕

日本腎臓学会誌 ((一社)日本腎臓学会)  57 ( 6 ) 956 - 956 2015.08

Joint Work,  ISSN  0385-2385

【病理診断クイックリファレンス】 (第9章)腎(非腫瘍) 膜性腎症

橋口, 明典

病理と臨床 33 ( 臨増 ) 132 2015.04

Joint Work,  ISSN  0287-3745

An Efficient Wavelet-Based ROI Coding for Multiple Regions

Shinoda, Kazuma, Kobayashi, Naoki, Katoh, Ayako, Komagata, Hideki, Ishikawa, Masahiro, Murakami, Yuri, Yamaguchi, Masahiro, Abe, Tokiya, Hashiguchi, Akinori, Sakamoto, Michiie

IEICE TRANSACTIONS ON FUNDAMENTALS OF ELECTRONICS COMMUNICATIONS AND COMPUTER SCIENCES (IEICE-INST ELECTRONICS INFORMATION COMMUNICATIONS ENG)  E98A ( 4 ) 1006 - 1020 2015.04

Research paper (scientific journal), Joint Work,  ISSN  1745-1337

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Region of interest (ROI) coding is a useful function for many applications. JPEG2000 supports ROI coding and can decode ROIs preferentially regardless of the shape and number of the regions. However, if the number of regions is quite large, the ROI coding performance of JPEG2000 declines because the code-stream includes many useless non-ROI codes. This paper proposes a wavelet-based ROI coding method suited for multiple ROIs. The proposed wavelet transform does not access any non-ROIs when transforming the ROIs. Additionally, the proposed method eliminates the need for unnecessary coding of the bits in the higher bit planes of non-ROI regions by adding an ROI map to the code-stream. The experimental results show that the proposed method achieves a higher peak signal-to-noise ratio than the ROI coding of JPEG2000. The proposed method can be applied to both max-shift and scaling-based ROI coding.

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【病理診断クイックリファレンス】 (第9章)腎(非腫瘍) ループス腎炎

橋口, 明典

病理と臨床 33 ( 臨増 ) 134 2015.04

Joint Work,  ISSN  0287-3745

【病理診断クイックリファレンス】 (第9章)腎(非腫瘍) 糖尿病性腎症

橋口, 明典

病理と臨床 33 ( 臨増 ) 133 2015.04

Joint Work,  ISSN  0287-3745

NAFLDにおけるDual energy CTを用いた肝脂肪変性定量評価の有用

岡部 純弥, 澤井 良之, 福田 和人, 井倉 技, 小来田 幸世, 今井 康陽, 磯谷 圭介, 米澤 稔, 藤田 典彦, 兵頭 朋子, 辻川 華子, 阿部 時也, 橋口 明典, 坂元 亨宇, 村上 卓道

肝臓 ((一社)日本肝臓学会)  56 ( Suppl.1 ) A359 - A359 2015.04

Joint Work,  ISSN  0451-4203

市販の下剤多量内服による薬剤性の関与が疑われた広範な糸球体硬化と肝硬変の一例

高畑 尚, 徳山 博文, 脇野 修, 橋口 明典, 小西 孝之助, 林 晃一, 伊藤 裕

日本内分泌学会雑誌 ((一社)日本内分泌学会)  91 ( 1 ) 327 - 327 2015.04

Joint Work,  ISSN  0029-0661

An accurate method of extracting fat droplets in liver images for quantitative evaluation

Ishikawa, Masahiro, Kobayashi, Naoki, Komagata, Hideki, Shinoda, Kazuma, Yamaguchi, Masahiro, Abe, Tokiya, Hashiguchi, Akinori, Sakamoto, Michiie

Medical Imaging 2015: Digital Pathology 9420 2015

Joint Work, Accepted

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Enhancing automatic classification of hepatocellular carcinoma images through image masking, tissue changes and trabecular features.

Aziz, Maulana Abdul, Kanazawa, Hiroshi, Murakami, Yuri, Kimura, Fumikazu, Yamaguchi, Masahiro, Kiyuna, Tomoharu, Yamashita, Yoshiko, Saito, Akira, Ishikawa, Masahiro, Kobayashi, Naoki, Abe, Tokiya, Hashiguchi, Akinori, Sakamoto, Michiie

Journal of pathology informatics 6   26 - 26 2015

Joint Work, Accepted

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Overexpression of CXCR4 on circulating B cells in patients with active systemic lupus erythematosus

Hironari Hanaoka, Yuka Okazaki, Akinori Hashiguchi, Hidekata Yasuoka, Tsutomu Takeuchi, Masataka Kuwana

Clinical and Experimental Rheumatology (Clinical and Experimental Rheumatology S.A.S.)  33 ( 6 ) 863 - 870 2015

Joint Work,  ISSN  1593-098X

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Objective: To evaluate the roles of circulating B cells in the pathogenic process of systemic lupus erythematosus (SLE) by measuring the expression of chemokines and their receptors. Methods: Peripheral-blood mononuclear cells were obtained from 17 active, 21 inactive SLE patients, and 13 healthy controls. The expression of CXCR4, CXCR5, and CCR7 on CD19+ B cells was determined by flow cytometry, serum concentration of CXCL12 was measured by enzyme-linked immunosorbent assay, and the chemotactic responsiveness of B cells toward CXCL12 was evaluated. B or plasma cells expressing CXCR4 in renal biopsy specimens were detected using immnofluorescent staining. Results: Flow cytometric analysis revealed that expression level of CXCR4 on circulating B cells was significantly higher in patients with active disease than in those with inactive disease or controls. Serum CXCL12 concentration was not different between these groups. In addition, the migratory ability of B cells toward CXCL12 was enhanced in active SLE patients. Finally, CXCR4-expressing B cells were more frequently observed in the renal biopsy specimens of lupus nephritis. Conclusion: Up-regulated CXCR4 expression on circulating B cells in active SLE may enhance their chemotactic response toward CXCL12, which may promote infiltration of these cells into inflamed renal tissue and contribute to the development of SLE.

Improvement in karyomegalic interstitial nephritis three years after ifosfamide and cisplatin therapy by corticosteroid

Matsuura, T, Wakino, S, Yoshifuji, A, Nakamura, T, Tokuyama, H, Hashiguchi, A, Konishi, K, Iwasa, T, Shoji, M, Hosono, A, Ohashi, K, Chuman, H, Itoh, H

CEN Case Rep 3 ( 2 ) 226 - 231 2014.11

Joint Work,  ISSN  2192-4449

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Long-term nephrotoxicity of ifosfamide is occasionally progressive, and, in such case, there has been no specific treatment to prevent progression. It has been reported that the presence of karyomegalic interstitial nephritis, which is rare type of interstitial nephritis, may be related to ifosfamide-induced nephropathy with poor prognosis and resistant to the immunosuppressive therapy. A 15-year-old boy presented with progressive nephrotoxicity 3 years after systemic chemotherapy with ifosfamide and cisplatin for the treatment of osteosarcoma. Renal biopsy revealed the severe tubulointerstitial nephritis with tubular atrophy and focal global and segmental glomerular sclerosis. It also showed tubular epithelial cells with variably sized nuclei, some of which were massively enlarged, abnormal hyperchromatic, irregular shaped, and bizarre-appearing. These morphological changes were suggestive of the histology of karyomegalic interstitial nephritis. Corticosteroid retarded the progression of nephrotoxicity. The present case is the first report, suggesting that corticosteroid was effective against the late-onset renal toxicity by ifosfamide therapy. Our case also suggests that karyomeg

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Rac1 accumulates in the nucleus at the invasive front of colorectal cancer through promoting cell motility

Funakoshi, Shinsuke, Takaishi, Hiromasa, Niibe-Kabashima, Ayano, Suzuki, Tomohiro, Sakai, Gen, Izumiya, Motoko, Adachi, Masayuki, Hamamoto, Yasuo, Higuchi, Hajime, Hashiguchi, Akinori, Tsukada, Nobuhiro, Kanai, Takanori

CANCER RESEARCH (AMER ASSOC CANCER RESEARCH)  74 ( 19 ) 865 - 870 2014.10

Research paper (scientific journal), Joint Work,  ISSN  0008-5472

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Up-Regulated Expression of CXCR4 on Circulating B Cells in Patients with Systemic Lupus Erythematosus

Hanaoka, Hironari, Okazaki, Yuka, Hashiguchi, Akinori, Yasuoka, Hidekata, Takeuchi, Tsutomu, Kuwana, Masataka

ARTHRITIS & RHEUMATOLOGY (WILEY-BLACKWELL)  66   S1177 - S1178 2014.10

Research paper (scientific journal), Joint Work,  ISSN  2326-5191

A rare association between Fabry's disease and granulomatosis with polyangiitis: a potential pathogenic link

Hironari Hanaoka, Akinori Hashiguchi, Konosuke Konishi, Tomohiro Ishii, Masataka Kuwana

BMC NEPHROLOGY (BIOMED CENTRAL LTD)  15   157 2014.10

Joint Work, Accepted,  ISSN  1471-2369

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Background: Fabry's disease is a rare X-linked, hereditary lysosomal storage disease caused by a deficiency of the enzyme alpha-galactosidase A. Granulomatosis with polyangiitis is characterized by the involvement of the respiratory tract and kidneys. Here, we report the first case of the coexistence of these diseases.
Case presentation: We describe a 29-year-old man suffering from fever with maxillary sinusitis, multiple lung nodules, and proteinuria. He was diagnosed with Fabry's disease accompanying granulomatosis with polyangiitis on the basis of the low activity of peripheral leukocyte alpha-galactosidase A and pathological findings in the lung and kidney. Glucocorticoid and cyclophosphamide were administered, followed by enzyme replacement therapy. Progression to end-stage renal disease has not been observed for 6 years until the time of drafting this manuscript.
Conclusion: Because both Fabry's disease and granulomatosis with polyangiitis or crescentic glomerulonephritis are rare diseases, their concurrence in this and related cases suggests there may be a pathogenic link between these two conditions. Fabry's disease may be underdiagnosed, particularly in cases of granulomatosis with polyangiitis or crescentic glomerulonephritis.

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Label-free visualization of acetaminophen-induced liver injury by high-speed stimulated Raman scattering spectral microscopy and multivariate image analysis

Shuya Satoh, Yoichi Otsuka, Yasuyuki Ozeki, Kazuyoshi Itoh, Akinori Hashiguchi, Ken Yamazaki, Hiroyuki Hashimoto, Michiie Sakamoto

PATHOLOGY INTERNATIONAL (WILEY-BLACKWELL)  64 ( 10 ) 518 - 526 2014.10

Joint Work, Accepted,  ISSN  1320-5463

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We recently established a high-speed, label-free, spectral imaging method based on stimulated Raman scattering (SRS). This method enables examination of cellular features within relatively short periods, thus enabling new imaging applications in pathology. Previously, we reported on label-free visualization of mouse tissue using SRS spectral microscopy combined with multivariate image analysis, but the feasibility of applying this approach to diseased tissues with diverse morphology and irregular chemical species has not been examined. We, therefore, assessed acetaminophen-induced liver injury to evaluate the potential use of Raman spectral microscopy for visualizing histopathologic specimens. Acetaminophen-overdosed mouse liver was prepared and the pathologic changes including centrilobular necrosis were confirmed. Multi-colored images were reconstructed through principal component analysis (PCA) of a multi-band SRS dataset, which provided rich information compared with a monochrome single-band SRS dataset. A wide view of the multi-colored principal component (PC) images showed the distribution of cellular constituents, which was similar to that observed by fat staining. In addition, different types of cells in liver parenchyma were also demonstrated. In conclusion, the combination of SRS spectral microscopy and PCA has the potential to reveal both the morphological and chemical features of specimens and therefore has potential utility in diagnostic pathology.

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腎生検所見から何を学ぶか(No.53) タクロリムスが上皮下沈着物に対して治療効果を示した難治性ループス腎炎の1例

野中, 香苗, 乳原, 善文, 諏訪部, 達也, 住田, 圭一, 平松, 里佳子, 長谷川, 詠子, 豊原, 敬文, 広浜, 大五郎, 山内, 真之, 山内, 淳司, 早見, 典子, 冨永, 直人, 星野, 純一, 澤, 直樹, 竹本, 文美, 黒田, 陽子, 大橋, 健一, 高市, 憲明, 橋口, 明典

腎と透析 77 ( 3 ) 389 - 398 2014.09

Joint Work,  ISSN  0385-2156

BCG膀胱内注入療法により誘発された腎サルコイドーシスの一例

新井 舞, 柏 真紀, 徳山 博文, 脇野 修, 橋口 明典, 林 松彦, 小西 孝之助, 林 晃一, 伊藤 裕

日本腎臓学会誌 ((一社)日本腎臓学会)  56 ( 6 ) 845 - 845 2014.08

Joint Work,  ISSN  0385-2385

急性骨髄性白血病(AML)に対して造血幹細胞移植施行後に微小血管病変(TMA)を発症した一例

浦井 秀徳, 徳山 博文, 脇野 修, 橋口 明典, 小西 孝之助, 林 晃一, 伊藤 裕

日本腎臓学会誌 ((一社)日本腎臓学会)  56 ( 6 ) 846 - 846 2014.08

Joint Work,  ISSN  0385-2385

ステロイドが著効した間質性腎炎を伴うLight chain tubulopathyの一例

内藤 真規子, 脇野 修, 橋口 明典, 徳山 博文, 小西 孝之助, 林 晃一, 林 松彦, 伊藤 裕

日本腎臓学会誌 ((一社)日本腎臓学会)  56 ( 6 ) 840 - 840 2014.08

Joint Work,  ISSN  0385-2385

HE染色肝病理標本における組織構造定量化によるがん検出精度向上の検討

石川, 雅浩, 藤田, 悠介, Aziz, Maulana Abdul, 村上, 百合, 山口, 雅浩, 小林, 直樹, 喜友名, 朝春, 齋藤, 彰, 阿部, 時也, 橋口, 明典, 坂元, 亨宇

MEDICAL IMAGING TECHNOLOGY 32 ( Suppl. ) 1 - 9 2014.07

Joint Work,  ISSN  0288-450X

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HE染色病理組織標本におけるコンピュータ診断支援の従来研究では、細胞核の形態的特徴を用いる場合が多いが、特に高分化がんあるいは早期がんの検出、診断においては核情報以上に組織構造が重要な役割を持っている。本発表では、肝細胞がんを対象として、これまでに我々が検討を行ってきた組織構造の特徴量をがんの識別に応用した基礎的な結果を報告する。具体的には、肝細胞索の層の厚さ、索構造の乱れ、肝細胞索ごとに算出したN/C比及び核密度などを画像から計測した結果、がんと非がんの間で有意差が認められた。さらに、これらの組織構造の特徴量を従来の細胞核の特徴量に加えることにより、がん識別の精度を向上する可能性が示された。本手法で用いた組織構造の特徴量は、病理組織標本のデジタルスライド画像から自動的に算出できるもので、定量的情報に基づくコンピュータ病理診断支援システムに有用なものと考えられる。(著者抄録)