Details of a Researcher - Hashiguchi, Akinori

Papers - Hashiguchi, Akinori

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Contrast-enhanced Ultrasonography of the Prostate with Sonazoid

Matsumoto, Kazuhiro, Nakagawa, Ken, Hashiguchi, Akinori, Kono, Hidaka, Kikuchi, Eiji, Nagata, Hirohiko, Miyajima, Akira, Oya, Mototsugu

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (OXFORD UNIV PRESS) 40 ( 11 ) 1099 - 1104 2010.11

Research paper (scientific journal), Joint Work, ISSN 0368-2811

The diagnosis of prostate cancer is based on the results of ultrasonography-guided needle biopsy of the prostate, but cancer foci are often not visible in conventional transrectal ultrasonography. Sonazoid is a new microbubble contrast agent. The purpose of our study was to compare areas of contrast material enhancement in the prostate at ultrasonography with whole-mount radical prostatectomy specimens to determine if the use of Sonazoid improves the detection rate of prostate cancer.
Fifty patients with biopsy-proven cancer of the prostate who were scheduled to undergo radical prostatectomy were recruited for this study. The day before the operation, each patient was evaluated with ultrasonography at baseline and again during intravenous infusion of Sonazoid. A map of ultrasonography findings was created prospectively at the time of imaging. Following radical prostatectomy, independent mapping of the pathologic results was performed and the maps were compared.
Ultrasonography evaluation at baseline demonstrated that at least one focus of cancer was identified in 20 of the 50 subjects (40.0%). Meanwhile at least one cancer focus was enhanced in 31 of the 50 patients (62.0%) when Sonazoid was used. The combination of baseline grayscale imaging and contrast-enhanced imaging allowed identification of at least one focus of cancer in 40 patients (80.0%). Contrast-enhanced ultrasonography can improve sensitivity, especially for the detection of large cancer, peripheral zone cancer and highly malignant cancer.
Our study has demonstrated significantly improved detection of prostate cancer with the combination of baseline grayscale imaging and contrast-enhanced imaging compared with conventional ultrasonography techniques only, and this technique may be applicable to targeted biopsy.

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Acute interstitial nephritis associated with ulcerative colitis

Tokuyama, H, Wakino, S, Konishi, K, Hashiguchi, A, Hayashi, K, Itoh, H

Clin Exp Nephrol 14 ( 5 ) 483 - 6 2010.10

Joint Work, ISSN 1342-1751

Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.

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血液透析患者に発症した小脳・脳幹型進行性多巣性白質脳症の1例

武田, 彩乃, 真杉, 洋平, 門川, 俊明, 石黒, 喜美子, 武光, 智子, 原, 義和, 伊東, 大介, 橋口, 明典, 小西, 孝之助, 林, 松彦, 伊藤, 裕

日本透析医学会雑誌 (The Japanese Society for Dialysis Therapy) 43 ( 9 ) 807 - 813 2010.09

Joint Work, ISSN 1340-3451

症例は55歳、女性。骨髄増殖性疾患に対する治療経過中に腎不全に至り、54歳時に血液透析導入となった。透析導入10ヵ月時に小脳失調症状が出現し、当院に入院となり、頭部MRIにて小脳にT2強調画像で異常信号を認めた。病変部位は小脳のみであり非特異的であったが、脳脊髄液検査にてJCウイルスPCR陽性であったことから、進行性多巣性白質脳症が第一に疑われた。病巣が急速に拡大するにつれて症状は進行し、不随意運動・構音障害・嚥下障害が出現、誤嚥性肺炎を繰り返すようになり、発症後10ヵ月(透析導入後20ヵ月)に死亡された。剖検にて小脳・脳幹部に脱髄を認め、同部位にJCウイルスの存在を確認し、小脳型進行性多巣性白質脳症の確定診断に至った。また本症例の透析導入前の腎生検を再度検討したところ萎縮・変性した尿細管上皮細胞内に一致して免疫組織化学ならびに電子顕微鏡的に多量のJCウイルス蛋白が確認された。一般に進行性多巣性白質脳症の中で小脳・脳幹を侵す病型は稀であるが、本邦の透析患者における進行性多巣性白質脳症では、小脳型の報告が散見されており、透析患者では小脳型が稀でない可能性がある。また、本症例において透析導入に至った腎不全の原因として、JCウイルス腎症が関与した可能性が高いことが示唆された。JCウイルス感染の腎障害における病的意義については不明な点が多く、今後、症例の蓄積による病態の解明が必要である。(著者抄録)

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蛍光定量デジタルスライド技術

橋口, 明典, 坂元, 亨宇

病理と臨床 28 ( 8 ) 878 - 881 2010.08

Joint Work, ISSN 0287-3745

Apolipoprotein AII変異による腎アミロイドーシスが疑われた一例

森實隆司, 門川俊明, 徳山博文, 橋口明典, 小西孝之助, 林晃一, 林松彦, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 674 - 674 2010.08

Joint Work, ISSN 0385-2385

膜性増殖性糸球体性腎炎(MPGN)type1にて生体腎移植後に再発した一例

小松素明, 徳山博文, 脇野修, 橋口明典, 小西孝之助, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 706 - 706 2010.08

Joint Work, ISSN 0385-2385

発症に肝切除の影響が疑われたIgA腎症の一例

水口斉, 脇野修, 徳山博文, 小西孝之助, 林晃一, 伊藤裕, 橋口明典

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 677 - 677 2010.08

Joint Work, ISSN 0385-2385

完全寛解後3ヵ月の経過で急性腎障害を呈し維持透析導入となった微小変化型ネフローゼ症候群の1例

山口慎太郎, 徳山博文, 脇野修, 橋口明典, 小西孝之助, 林松彦, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 673 - 673 2010.08

Joint Work, ISSN 0385-2385

妊娠初期に著明なネフローゼ症候群を呈した症例

丸山達也, 二木功治, 谷口友里, 市原淳弘, 林松彦, 徳山博文, 脇野修, 末岡浩, 峰岸一宏, 橋口明典, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 673 - 673 2010.08

Joint Work, ISSN 0385-2385

B型肝炎ウイルスキャリアーに発症した膜性増殖性糸球体腎炎

坂東和香, 脇野修, 徳山博文, 齋藤英胤, 橋口明典, 小西孝之助, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 677 - 677 2010.08

Joint Work, ISSN 0385-2385

肺血栓塞栓症慢性化のプロセスへの挑戦慢性血栓塞栓性肺高血圧症(CTEPH)症例における肺動脈血栓と大腿静脈血栓の類似性心内血栓例と剖検例からの考察

渡辺, 慎太郎, 小室, 哲也, 西村, 芳興, 山口, 佳寿博, 橋口, 明典, 坂田, 洋一

心臓 (Japan Heart Foundation) 42 ( 7 ) 1006 - 1007 2010.07

Joint Work, ISSN 0586-4488

症例1:77歳男。慢性閉塞性肺疾患(COPD)とされていたが、呼吸機能正常などより慢性血栓塞栓性肺高血圧症(CTEPH)と診断した。下肢静脈には高輝度びまん性血栓のみ認め、下大静脈フィルター(IVCF)は使用しなかった。しかし、その後酸素必要量が上昇して入院し、心エコーで右室内に小血栓像を認めた。永久型IVCFを留置し血栓溶解療法を施行したが、肺炎を併発して死亡した。症例2:84歳男。COPDとされていたが、呼吸困難、低酸素血症で入院し、右室負荷を認めてCTEPHと診断した。下肢静脈エコーで高輝度びまん性血栓を認め、入院2日目に死亡した。剖検所見で、左大腿静脈壁内膜の線維性肥厚を認め、器質化陳旧性血栓の所見がみられた。肺動脈内にも内膜の肥厚を認め、下肢静脈の器質化血栓と類似していた。肥厚が強い狭窄部には、剥離と新鮮血栓が形成されている箇所も認めた。

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腎生検所見から何を学ぶか(No.41) 急速進行性糸球体腎炎を呈した紫斑病性腎炎と思われる1例

林, 香, 橋本, 寿之, 篠村, 裕之, 林, 松彦, 小西, 孝之助, 伊藤, 裕, 橋口, 明典, 長田, 道夫

腎と透析 68 ( 5 ) 923 - 930 2010.05

Joint Work, ISSN 0385-2156

橋口, 明典

医学のあゆみ 232 ( 11 ) 1121 - 1126 2010.03

Joint Work, ISSN 0039-2359

IgA腎症は幅広い臨床像を有し、これらの予後を予測するために、数々の組織学的分類が提唱されてきた。2008年、厚生労働省進行性腎障害研究班IgA腎症分科会があらたな病理組織分類を提案する一方、2009年、国際IgA腎症ネットワーク(International IgA Nephropathy Network)およびRenal Pathology Societyのワーキンググループより、いわゆるオックスフォード分類が発表されるに至り、その相違がわが国において混乱を招く危険性を帯びてきた。本稿ではそれぞれの分類の特徴を述べ、両者を比較検討することにより、双方の組織分類の問題点について考察する。(著者抄録)

根治術が施行された前立腺癌における生検本数と病理組織学的所見の比較検討

古内徹, 水野隆一, 中島淳, 向井万起男, 橋口明典, 香野日高, 菊地栄次, 長田浩彦, 宮嶋哲, 中川健, 大家基嗣

日本泌尿器科学会雑誌 ((一社)日本泌尿器科学会) 101 ( 2 ) 438 - 438 2010.02

Joint Work, ISSN 0021-5287

PSA腫瘍密度による限局性前立腺癌の病理学的病期の予測

水野隆一, 中島淳, 向井万起男, 橋口明典, 香野日高, 菊地栄次, 長田浩彦, 浅沼宏, 宮嶋哲, 中川健, 大家基嗣

日本泌尿器科学会雑誌 ((一社)日本泌尿器科学会) 101 ( 2 ) 192 - 192 2010.02

Joint Work, ISSN 0021-5287

A Case of IgA-related Enteropathy Complicated with Gastrointestinal Bleeding and Progressive IgA Nephropathy: A Possible Variant Henoch-Schonlein Purpura?

Nakamura, Shoko, Hisamatsu, Tadakazu, Kikuchi, Jun, Adachi, Masayuki, Yamagishi, Yoshiyuki, Imaeda, Hiroyuki, Hosoe, Naoki, Naganuma, Makoto, Ebinuma, Hirotoshi, Okamoto, Susumu, Kanai, Takanori, Ogata, Haruhiko, Hanaoka, Hironari, Furuya, Yoshiaki, Kawano, Yoshinaga, Bokuda, Kanako, Sasamura, Hiroyuki, Uchida, Hiroshi, Endo, Takashi, Hashiguchi, Akinori, Kameyama, Kaori, Mukai, Makio, Hibi, Toshifumi

INTERNAL MEDICINE 49 ( 16 ) 1755 - 1761 2010

Research paper (scientific journal), ISSN 0918-2918

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A Case of IgA-related Enteropathy Complicated with Gastrointestinal Bleeding and Progressive IgA Nephropathy: A Possible Variant Henoch-Schonlein Purpura?

INTERNAL MEDICINE 49 ( 16 ) 1755 - 1761 2010

Research paper (scientific journal), ISSN 0918-2918

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Are predictive models for cancer volume clinically useful in localized prostate cancer?

Ishida, Masaru, Nakashima, Jun, Hashiguchi, Akinori, Mizuno, Ryuichi, Shinoda, Kazunobu, Kikuchi, Eiji, Miyajima, Akira, Nakagawa, Ken, Mukai, Makio, Oya, Mototsugu

INTERNATIONAL JOURNAL OF UROLOGY (WILEY-BLACKWELL PUBLISHING, INC) 16 ( 12 ) 936 - 940 2009.12

Research paper (scientific journal), Joint Work, ISSN 0919-8172

Objectives:
To evaluate the correlation between preoperatively predicted and pathologically measured prostate cancer volumes and to investigate the clinical use of preoperatively predicted cancer volume in predicting pathological stage.
Methods:
Correlations between pathological findings and various preoperative parameters, including the cancer volumes as predicted by using two methods (Vca and estimated PCvol), were analyzed in 196 patients who underwent radical prostatectomy for clinically localized prostate cancer.
Results:
Pathologically measured prostate cancer volume was significantly correlated with the Vca and estimated PCvol, but the correlation coefficients were respectively only 0.46 and 0.35. Prostate-specific antigen (PSA), PSA density (PSAD), primary Gleason score, Vca, Vca fraction (Vcafx), and estimated PCvol were significantly higher in 82 patients with extraprostatic cancer than in 114 patients with organ-confined cancer. Magnetic resonance imaging (MRI) findings were significantly correlated with pathological stage. Multivariate logistic regression analysis indicated that the Vcafx and MRI findings were significant predictors of extraprostatic cancer, but receiver operating characteristic analysis revealed that the combination of Vcafx and MRI findings had no advantage over the combination of Gleason score, PSAD, and MRI findings.
Conclusions:
Vca and estimated PCvol are significantly correlated with the pathologically measured cancer volume but their ability to accurately predict cancer volume is limited. Vcafx and MRI findings were statistically significant predictors of extraprostatic cancer but their combination was not superior to the combination of Gleason score, PSAD, and MRI findings.

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Construction of human monoclonal single-chain Fv antibodies against small-cell lung cancer by phage display libraries derived from cell-immunized SCID mice engrafted with human peripheral blood lymphocytes

Douguchi, Junya, Hashiguchi, Akinori, Sakamoto, Michiie

PROTEOMICS CLINICAL APPLICATIONS (WILEY-V C H VERLAG GMBH) 3 ( 11 ) 1265 - 1272 2009.11

Research paper (scientific journal), Joint Work, ISSN 1862-8346

In this study, we describe a phage display strategy to obtain human monoclonal single-chain Fv (scFv) antibodies binding target cancer cell surface proteins. By developing a cancer cell immunization protocol for SCID mice engrafted with human peripheral blood lymphocytes in combination with an antibody phage display method, we have isolated phage antibodies binding small-cell lung cancer cell line H889 by subtractive selection. One of the isolated scFv antibodies, 12EAb, recognized the E2 component of pyruvate dehydrogenase complex (PDC-E2) by immunoprecipitation according to MALDI-TOF MS analysis. Furthermore, we have confirmed the plasma membrane localization of PDC-E2 in small-cell lung cancer cells by immunocytochemistry and cell surface protein biotinylation, although PDC-E2 is usually located in the mitochondrial matrix. These results, including unique localization of identified antigens, were obtained by proteomic approaches. The present methods can be applied to generate human monoclonal scFv antibodies against tumor cells and to identify new molecular targets for immunotherapy and markers for diagnosis.

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第2世代超音波造影剤(ソナゾイド)の前立腺癌描出に関する有用性の検討

松本, 一宏, 中川, 健, 橋口, 明典, 香野, 日高, 菊地, 栄次, 宮嶋, 哲, 中島, 淳, 大家, 基嗣

泌尿器外科 (医学図書出版(株)) 22 ( 8 ) 1061 - 1062 2009.08

Joint Work, ISSN 0914-6180

第2世代超音波造影剤(ソナゾイド)の前立腺癌描出に関する有用性につきProspectiveに検討を行った。前立腺全摘術を予定された患者を対象とし、術前に検査を実施し腫瘍局在を同定した。前立腺摘出検体の病理組織結果と比較したところ、高率に癌病巣を描出できていた。Gleason's score高値や被膜浸潤陽性症例においては、正診率はさらに上昇した。前立腺生検時に応用することにより、偽陰性となっていた患者の早期発見に繋がる可能性が示唆された。(著者抄録)

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