Details of a Researcher - Hashiguchi, Akinori

Papers - Hashiguchi, Akinori

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完全寛解後3ヵ月の経過で急性腎障害を呈し維持透析導入となった微小変化型ネフローゼ症候群の1例

山口慎太郎, 徳山博文, 脇野修, 橋口明典, 小西孝之助, 林松彦, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 673 - 673 2010.08

Joint Work, ISSN 0385-2385

妊娠初期に著明なネフローゼ症候群を呈した症例

丸山達也, 二木功治, 谷口友里, 市原淳弘, 林松彦, 徳山博文, 脇野修, 末岡浩, 峰岸一宏, 橋口明典, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 673 - 673 2010.08

Joint Work, ISSN 0385-2385

B型肝炎ウイルスキャリアーに発症した膜性増殖性糸球体腎炎

坂東和香, 脇野修, 徳山博文, 齋藤英胤, 橋口明典, 小西孝之助, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 52 ( 6 ) 677 - 677 2010.08

Joint Work, ISSN 0385-2385

肺血栓塞栓症慢性化のプロセスへの挑戦慢性血栓塞栓性肺高血圧症(CTEPH)症例における肺動脈血栓と大腿静脈血栓の類似性心内血栓例と剖検例からの考察

渡辺, 慎太郎, 小室, 哲也, 西村, 芳興, 山口, 佳寿博, 橋口, 明典, 坂田, 洋一

心臓 (Japan Heart Foundation) 42 ( 7 ) 1006 - 1007 2010.07

Joint Work, ISSN 0586-4488

症例1:77歳男。慢性閉塞性肺疾患(COPD)とされていたが、呼吸機能正常などより慢性血栓塞栓性肺高血圧症(CTEPH)と診断した。下肢静脈には高輝度びまん性血栓のみ認め、下大静脈フィルター(IVCF)は使用しなかった。しかし、その後酸素必要量が上昇して入院し、心エコーで右室内に小血栓像を認めた。永久型IVCFを留置し血栓溶解療法を施行したが、肺炎を併発して死亡した。症例2:84歳男。COPDとされていたが、呼吸困難、低酸素血症で入院し、右室負荷を認めてCTEPHと診断した。下肢静脈エコーで高輝度びまん性血栓を認め、入院2日目に死亡した。剖検所見で、左大腿静脈壁内膜の線維性肥厚を認め、器質化陳旧性血栓の所見がみられた。肺動脈内にも内膜の肥厚を認め、下肢静脈の器質化血栓と類似していた。肥厚が強い狭窄部には、剥離と新鮮血栓が形成されている箇所も認めた。

腎生検所見から何を学ぶか(No.41) 急速進行性糸球体腎炎を呈した紫斑病性腎炎と思われる1例

林, 香, 橋本, 寿之, 篠村, 裕之, 林, 松彦, 小西, 孝之助, 伊藤, 裕, 橋口, 明典, 長田, 道夫

腎と透析 68 ( 5 ) 923 - 930 2010.05

Joint Work, ISSN 0385-2156

橋口, 明典

医学のあゆみ 232 ( 11 ) 1121 - 1126 2010.03

Joint Work, ISSN 0039-2359

IgA腎症は幅広い臨床像を有し、これらの予後を予測するために、数々の組織学的分類が提唱されてきた。2008年、厚生労働省進行性腎障害研究班IgA腎症分科会があらたな病理組織分類を提案する一方、2009年、国際IgA腎症ネットワーク(International IgA Nephropathy Network)およびRenal Pathology Societyのワーキンググループより、いわゆるオックスフォード分類が発表されるに至り、その相違がわが国において混乱を招く危険性を帯びてきた。本稿ではそれぞれの分類の特徴を述べ、両者を比較検討することにより、双方の組織分類の問題点について考察する。(著者抄録)

根治術が施行された前立腺癌における生検本数と病理組織学的所見の比較検討

古内徹, 水野隆一, 中島淳, 向井万起男, 橋口明典, 香野日高, 菊地栄次, 長田浩彦, 宮嶋哲, 中川健, 大家基嗣

日本泌尿器科学会雑誌 ((一社)日本泌尿器科学会) 101 ( 2 ) 438 - 438 2010.02

Joint Work, ISSN 0021-5287

PSA腫瘍密度による限局性前立腺癌の病理学的病期の予測

水野隆一, 中島淳, 向井万起男, 橋口明典, 香野日高, 菊地栄次, 長田浩彦, 浅沼宏, 宮嶋哲, 中川健, 大家基嗣

日本泌尿器科学会雑誌 ((一社)日本泌尿器科学会) 101 ( 2 ) 192 - 192 2010.02

Joint Work, ISSN 0021-5287

A Case of IgA-related Enteropathy Complicated with Gastrointestinal Bleeding and Progressive IgA Nephropathy: A Possible Variant Henoch-Schonlein Purpura?

Nakamura, Shoko, Hisamatsu, Tadakazu, Kikuchi, Jun, Adachi, Masayuki, Yamagishi, Yoshiyuki, Imaeda, Hiroyuki, Hosoe, Naoki, Naganuma, Makoto, Ebinuma, Hirotoshi, Okamoto, Susumu, Kanai, Takanori, Ogata, Haruhiko, Hanaoka, Hironari, Furuya, Yoshiaki, Kawano, Yoshinaga, Bokuda, Kanako, Sasamura, Hiroyuki, Uchida, Hiroshi, Endo, Takashi, Hashiguchi, Akinori, Kameyama, Kaori, Mukai, Makio, Hibi, Toshifumi

INTERNAL MEDICINE 49 ( 16 ) 1755 - 1761 2010

Research paper (scientific journal), ISSN 0918-2918

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A Case of IgA-related Enteropathy Complicated with Gastrointestinal Bleeding and Progressive IgA Nephropathy: A Possible Variant Henoch-Schonlein Purpura?

INTERNAL MEDICINE 49 ( 16 ) 1755 - 1761 2010

Research paper (scientific journal), ISSN 0918-2918

Access to Document (DOI)

Are predictive models for cancer volume clinically useful in localized prostate cancer?

Ishida, Masaru, Nakashima, Jun, Hashiguchi, Akinori, Mizuno, Ryuichi, Shinoda, Kazunobu, Kikuchi, Eiji, Miyajima, Akira, Nakagawa, Ken, Mukai, Makio, Oya, Mototsugu

INTERNATIONAL JOURNAL OF UROLOGY (WILEY-BLACKWELL PUBLISHING, INC) 16 ( 12 ) 936 - 940 2009.12

Research paper (scientific journal), Joint Work, ISSN 0919-8172

Objectives:
To evaluate the correlation between preoperatively predicted and pathologically measured prostate cancer volumes and to investigate the clinical use of preoperatively predicted cancer volume in predicting pathological stage.
Methods:
Correlations between pathological findings and various preoperative parameters, including the cancer volumes as predicted by using two methods (Vca and estimated PCvol), were analyzed in 196 patients who underwent radical prostatectomy for clinically localized prostate cancer.
Results:
Pathologically measured prostate cancer volume was significantly correlated with the Vca and estimated PCvol, but the correlation coefficients were respectively only 0.46 and 0.35. Prostate-specific antigen (PSA), PSA density (PSAD), primary Gleason score, Vca, Vca fraction (Vcafx), and estimated PCvol were significantly higher in 82 patients with extraprostatic cancer than in 114 patients with organ-confined cancer. Magnetic resonance imaging (MRI) findings were significantly correlated with pathological stage. Multivariate logistic regression analysis indicated that the Vcafx and MRI findings were significant predictors of extraprostatic cancer, but receiver operating characteristic analysis revealed that the combination of Vcafx and MRI findings had no advantage over the combination of Gleason score, PSAD, and MRI findings.
Conclusions:
Vca and estimated PCvol are significantly correlated with the pathologically measured cancer volume but their ability to accurately predict cancer volume is limited. Vcafx and MRI findings were statistically significant predictors of extraprostatic cancer but their combination was not superior to the combination of Gleason score, PSAD, and MRI findings.

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Construction of human monoclonal single-chain Fv antibodies against small-cell lung cancer by phage display libraries derived from cell-immunized SCID mice engrafted with human peripheral blood lymphocytes

Douguchi, Junya, Hashiguchi, Akinori, Sakamoto, Michiie

PROTEOMICS CLINICAL APPLICATIONS (WILEY-V C H VERLAG GMBH) 3 ( 11 ) 1265 - 1272 2009.11

Research paper (scientific journal), Joint Work, ISSN 1862-8346

In this study, we describe a phage display strategy to obtain human monoclonal single-chain Fv (scFv) antibodies binding target cancer cell surface proteins. By developing a cancer cell immunization protocol for SCID mice engrafted with human peripheral blood lymphocytes in combination with an antibody phage display method, we have isolated phage antibodies binding small-cell lung cancer cell line H889 by subtractive selection. One of the isolated scFv antibodies, 12EAb, recognized the E2 component of pyruvate dehydrogenase complex (PDC-E2) by immunoprecipitation according to MALDI-TOF MS analysis. Furthermore, we have confirmed the plasma membrane localization of PDC-E2 in small-cell lung cancer cells by immunocytochemistry and cell surface protein biotinylation, although PDC-E2 is usually located in the mitochondrial matrix. These results, including unique localization of identified antigens, were obtained by proteomic approaches. The present methods can be applied to generate human monoclonal scFv antibodies against tumor cells and to identify new molecular targets for immunotherapy and markers for diagnosis.

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第2世代超音波造影剤(ソナゾイド)の前立腺癌描出に関する有用性の検討

松本, 一宏, 中川, 健, 橋口, 明典, 香野, 日高, 菊地, 栄次, 宮嶋, 哲, 中島, 淳, 大家, 基嗣

泌尿器外科 (医学図書出版(株)) 22 ( 8 ) 1061 - 1062 2009.08

Joint Work, ISSN 0914-6180

第2世代超音波造影剤(ソナゾイド)の前立腺癌描出に関する有用性につきProspectiveに検討を行った。前立腺全摘術を予定された患者を対象とし、術前に検査を実施し腫瘍局在を同定した。前立腺摘出検体の病理組織結果と比較したところ、高率に癌病巣を描出できていた。Gleason's score高値や被膜浸潤陽性症例においては、正診率はさらに上昇した。前立腺生検時に応用することにより、偽陰性となっていた患者の早期発見に繋がる可能性が示唆された。(著者抄録)

病理最前線腎臓-腎硬化症の語りかけるもの

橋口, 明典

医と食 1 ( 3 ) 2 - 3 2009.08

Joint Work, ISSN 1883-6658

CKDの発症からシェーグレン症候群と診断に至った一例

侯金成, 徳山博文, 脇野修, 橋口明典, 小西孝之助, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 51 ( 6 ) 672 - 672 2009.08

Joint Work, ISSN 0385-2385

肝硬変および糖尿病の影響が疑われた結節性糸球体硬化症の一例

水口斉, 脇野修, 立松覚, 徳山博文, 小西孝之助, 林晃一, 伊藤裕, 橋口明典

日本腎臓学会誌 ((一社)日本腎臓学会) 51 ( 6 ) 664 - 664 2009.08

Joint Work, ISSN 0385-2385

クローン病に腎および腸管アミロイドーシスを合併した一例

籠尾壽哉, 徳山博文, 脇野修, 橋口明典, 小西孝之助, 林松彦, 林晃一, 伊藤裕

日本腎臓学会誌 ((一社)日本腎臓学会) 51 ( 6 ) 650 - 650 2009.08

Joint Work, ISSN 0385-2385

治療抵抗性を示し15年間低補体血症が持続した後自然軽快した1型MPGNの1症例

上原朋子, 遠海重裕, 五月女友美子, 松山健, 本田雅敬, 粟津緑, 橋口明典

日本小児腎臓病学会雑誌 ((一社)日本小児腎臓病学会) 22 ( 1Suppl. ) 123 - 123 2009.06

Joint Work, Accepted, ISSN 0915-2245

Synuclein-gamma Is Closely Involved in Perineural Invasion and Distant Metastasis in Mouse Models and Is a Novel Prognostic Factor in Pancreatic Cancer

Hibi, Taizo, Mori, Taisuke, Fukuma, Mariko, Yamazaki, Ken, Hashiguchi, Akinori, Yamada, Taketo, Tanabe, Minoru, Aiura, Koichi, Kawakami, Takao, Ogiwara, Atsushi, Kosuge, Tomoo, Kitajima, Masaki, Kitagawa, Yuko, Sakamoto, Michiie

CLINICAL CANCER RESEARCH (AMER ASSOC CANCER RESEARCH) 15 ( 8 ) 2864 - 2871 2009.04

Research paper (scientific journal), Joint Work, ISSN 1078-0432

Purpose: Perineural invasion is associated with the high incidence of local recurrence and a dismal prognosis in pancreatic cancer. We previously reported a novel perineural invasion model and distinguished high- and low-perineural invasion groups in pancreatic cancer cell lines. This study aimed to elucidate the molecular mechanism of perineural invasion.
Experimental Design: To identify key biological markers involved in perineural invasion, differentially expressed molecules were investigated by proteomics and transcriptomics. Synuclein-gamma emerged as the only up-regulated molecule in high-perineural invasion group by both analyses. The clinical significance and the biological property of synuclein-gamma were examined in 62 resected cases of pancreatic cancer and mouse models.
Results: Synuclein-gamma overexpression was observed in 38 (61%) cases and correlated with major invasive parameters, including perineural invasion and lymph node metastasis (P < 0.05). Multivariate analyses revealed synuclein-gamma overexpression as the only independent predictor of diminished overall survival [hazard ratio, 3.4 (95% confidence interval, 1.51-7.51)] and the strongest negative indicator of disease-free survival [2.8 (1.26-6.02)]. In mouse perineural invasion and orthotopic transplantation models, stable synuclein-gamma suppression by short hairpin RNA significantly reduced the incidence of perineural invasion (P = 0.009) and liver/lymph node metastasis (P = 0.019 and P = 0.020, respectively) compared with the control.
Conclusions: This is the first study to provide in vivo evidence that synuclein-gamma is closely involved in perineural invasion/distant metastasis and is a significant prognostic factor in pancreatic cancer. Synuclein-gamma may serve as a promising molecular target of early diagnosis and anticancer therapy.

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腹腔鏡下右副腎摘除術、腹腔鏡下左副腎部分切除術を一期的に施行した両側副腎褐色細胞腫の1例

武田利和, 宮嶋哲, 柴田洋孝, 橋口明典, 菊地栄次, 中川健, 伊藤裕, 大家基嗣

日本内分泌外科学会総会プログラム・抄録集 ((一社)日本内分泌外科学会) 21回 105 - 105 2009.04

Joint Work

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