Details of a Researcher - Sugai, Takeshi

Papers - Sugai, Takeshi

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Synthesis of the Racemic and Optically Active Forms of Gizzerosine, the Inducer of Gizzard Erosion in Chicks

K. Mori, T. Sugai, Y. Maeda, T. Okazaki, T. Noguchi, H. Naito

Tetrahedron 41 5307-5311 1985.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthesis of (S)-2-Hydroxy-β-ionone, Employing (S)-3-Hydroxy-2,2-dimethylcyclohexanone as the Chiral Starting Material

M. Yanai, T. Sugai, K. Mori

Agric. Biol. Chem. 49 2373-2377 1985.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Biochemical Preparations of Both the Enantiomers of Methyl 3-Hydroxypentanoate and their Conversion to the Enantiomers of 4-Hexanolide, the Pheromone of Trogoderma glabrum

K. Mori, H. Mori, T. Sugai

Tetrahedron 41 919-925 1985.03

Research paper (conference, symposium, etc.), Joint Work, Accepted

Preparation of (R)-Ibuprofen and Related Carboxylic Acids Using Microbial Oxidation of an Aromatic Hydrocarbon by Rhodococcus sp. BPM 1613

T. Sugai, K. Mori

Agric. Biol. Chem. 48 2501-2504 1984.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Synthesis of Both the Enantiomers of 4-Dodecanolide, a Defensive Secretion of Rove Beetles

T. Sugai, K. Mori

Agric. Biol. Chem. 48 2496-2500 1984.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

Both Enantiomers of 8-Hydroxyhexadecanoic Acid Inhibit the Spore Germination of Lygodium japonicum

T. Sugai, K. Mori

Agric. Biol. Chem. 48 2155-2156 1984.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

The Absolute Structure and Activity Relationships of Major Secondary Alcohols of Pyrethroid Insecticides

N. Matsuo, T. Yano, H. Yoshioka, S. Kuwahara, T. Sugai, K. Mori

IUPAC Pesticide Chemistry, 'Human Welfare and the Environment' 279-284 1983.12

Research paper (conference, symposium, etc.), Joint Work, Accepted

微生物を利用した3-ヒドロキシブタン酸エチルの両鏡像体の調製法

須貝威、藤田満、森謙治

日本化学会誌 1315-1320 1983.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Preparation of Optically Active Secondary Alcohols Related to Synthetic Pyrethroids by Microbial Asymmetric Hydrolysis of the Corresponding Acetates

T. Sugai, S. Kuwahara, C. Hoshino, N. Matsuo, K. Mori

Agric. Biol. Chem. 46 2579-2585 1982.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

Ethyl (S)-3-hydroxybutanoate as a Starting Material for the Synthesis of (S)-(-)-Citronellol and Other Chiral Alcohols

T. Sugai, K. Mori

Synthesis 752-753 1982.07

Research paper (conference, symposium, etc.), Joint Work, Accepted

Inhibition of cellular and animal inflammatory disease models by nf-κb inhibitor dhmeq

Ma J., Zhang Y., Sugai T., Kubota T., Keino H., El-Salhy M., Ozaki M., Umezawa K.

Cells (Cells) 10 ( 9 ) 2021.09

General inflammatory diseases include skin inflammation, rheumatoid arthritis, inflammatory bowel diseases, sepsis, arteriosclerosis, and asthma. Although these diseases have been extensively studied, most of them are still difficult to treat. Meanwhile, NF-κB is a transcription factor promoting the expression of many inflammatory mediators. NF-κB is likely to be involved in the mechanism of most inflammatory diseases. We discovered a specific NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), about 20 years ago by molecular design from a natural product. It directly binds to and inactivates NF-κB components. It has been widely used to suppress cellular and animal inflammatory disease models and was shown to be potent in vivo anti-inflammatory activity without any toxicity. We have prepared ointment of DHMEQ for the treatment of severe skin inflammation. It inhibited inflammatory cytokine expressions and lowered the clinical score in mouse models of atopic dermatitis. Intraperitoneal (IP) administration of DHMEQ ameliorated various disease models of inflammation, such as rheumatoid arthritis, sepsis, and also graft rejection. It has been suggested that inflammatory cells in the peritoneal cavity would be important for most peripheral inflammation. In the present review, we describe the synthesis, mechanism of action, and cellular and in vivo anti-inflammatory activities and discuss the clinical use of DHMEQ for inflammatory diseases.

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Syntheses of Englerin A, a Potent Renal Cancer Inhibitor

Hagihara S., Hanaya K., Sugai T., Shoji M.

Asian Journal of Organic Chemistry (Asian Journal of Organic Chemistry) 8 ( 1 ) 48 - 62 2019.01

ISSN 21935807

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Mankind has been searching for anticancer drugs from nature and artificial compounds. Since the discovery of englerin A, a guaiane sesquiterpene possessing the characteristic tricyclic 5–6-5 fused ring framework with contiguous seven stereogenic centers and isolated from Phyllanthus engleri, many synthetic groups have enthusiastically launched and accomplished its the chemical synthesis. All the synthetic groups focused on how to efficiently construct the tricyclic framework containing oxygen bridge with various approaches. In this review, the total and formal syntheses of englerin A reported to date are summarized.

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Recent examples of the use of biocatalysts with high accessibility and availability in natural product synthesis (Tetrahedron Report No. 1164)

Sugai T., Higashibayashi S., Hanaya K.

Tetrahedron (Tetrahedron) 74 ( 27 ) 3469 - 3487 2018.07

ISSN 00404020

© 2018 Elsevier Ltd Utilization of biocatalysts with high accessibility and availability, which have recently been applied in the preparation of enantiomerically enriched starting materials and synthetic intermediates for natural product syntheses (mainly 2013–2017) are summarized in this review. The main contents are as follows: 1) recruitment of biocatalysts for the transformation of organic compounds; 2) special precautions for preparative-scale biocatalytic synthetic experiments; 3) asymmetric reduction of carbonyl substrates; 4) kinetic resolution of alcohol and carboxylate enantiomers; 5) desymmetrization of multifunctional alcohol and carboxylate substrates; and 6) recognition of remote and non-central chirality.

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Process Development with Bifunctional Chiral Epoxides to Acess Single Enantiomers of Pharmaceutical Intermediates

M. Ikunaka, T. Sugai

J. Oil Palm Res. 143-158 2008.10

Research paper (conference, symposium, etc.), Joint Work, Accepted

Enzyme Reactions as Key-steps for the Synthesis of Terpenoids, Degraded Carotenoids, Steroids, and Related Substances

K. Fuhshuku, S. Oda, T. Sugai

Recent Res. Devel. Org. Chem. 6 57-74 2002.02

Research paper (conference, symposium, etc.), Joint Work, Accepted

Application of Enzyme- and Microorganism-catalyzed Reactions to Organic Synthesis

T. Sugai

Curr. Org. Chem. 3 373-406 1999.06

Research paper (conference, symposium, etc.), Single Work, Accepted

Biocatalysis in Organic Synthesis: The Use of Nitrile- and Amide-Hydrolyzing Microorganisms

T. Sugai, T. Yamazaki, M. Yokoyama, H. Ohta

Biosci. Biotechnol. Biochem. 61 1419-1427 1997.09

Research paper (conference, symposium, etc.), Joint Work, Accepted

Aldolase Catalyzed Reaction for Carbohydrate Synthesis

T. Kajimoto, T. Sugai, C.-H. Wong

Trends in Glycosci. Glycotechnol. 5 193-207 1993.05

Research paper (conference, symposium, etc.), Joint Work, Accepted

8-Quinolinol誘導体の化学反応とバイオケミカルツール・酵素阻害剤への応用

青木伸、有安真也、花屋賢悟、久松洋介、須貝威

有機合成化学協会誌 74 482-493 2016.04

Research paper (conference, symposium, etc.), Joint Work, Accepted

酵素を用いて鏡像異性体を分ける、創る、速度論的分割の力

古田未有、桑田和明、花屋賢悟、庄司満、須貝威

生物工学会誌 92 298-302 2014.06

Research paper (conference, symposium, etc.), Joint Work, Accepted

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