Papers - Aoki, Daisuke

Living donor surgery in uterus transplantation: A delicate hysterectomy technique in gynecological surgery

Kisu I, Banno K, Aoki D

J Obstet Gynaecol Res 48 ( 10 ) 2652 - 2653 2022.10

Research paper (scientific journal), Last author

Efficacy and safety of olaparib maintenance monotherapy for Japanese patients with platinum-sensitive relapsed ovarian, fallopian tube, and primary peritoneal cancer

Yoshihama T, Kuroda Y, Chiyoda T, Takahashi M, Yoshimura T, Saotome K, Nanki Y, Sakai K, Kobayashi Y, Yamagami W, Aoki D

Int J Clin Oncol 27 ( 10 ) 1644 - 1650 2022.10

Research paper (scientific journal), Last author

Development of a prognostic prediction support system for cervical intraepithelial neoplasia using artificial intelligence-based diagnosis

Takahashi T, Matsuoka H, Sakurai R, Akatsuka J, Kobayashi Y, Nakamura M, Iwata T, Banno K, Matsuzaki M, Takayama J, Aoki D, Yamamoto Y, Tamiya G

J Gynecol Oncol 33 ( 5 ) e57 2022.09

Research paper (scientific journal), Joint Work

Current status of hereditary breast and ovarian cancer practice among gynecologic oncologists in Japan: a nationwide survey by the Japan Society of Gynecologic Oncology (JSGO)

Kobayashi Y, Masuda K, Hiraswa A, Takehara K, Tsuda H, Watanabe Y, Oda K, Nagase S, Mandai M, Okamoto A, Yaegashi N, Mikami M, Enomoto T, Aoki D, Katabuchi H; Working Group on Clinical Practice for Cancer Genomic Medicine and HBOC, Japan Society of Gynecologic Oncology

J Gynecol Oncol 33 ( 5 ) e61 2022.09

Research paper (scientific journal)

Incidence of fistula occurrence in patients with cervical cancer treated with bevacizumab: data from real-world clinical practice

Sugiyama T, Katsumata N, Toita T, Ura M, Shimizu A, Kamijima S, Aoki D

Int J Clin Oncol 27 ( 9 ) 1517 - 1528 2022.09

Research paper (scientific journal), Joint Work, Last author

Current status of hereditary breast and ovarian cancer practice among gynecologic oncologists in Japan: a nationwide survey by the Japan Society of Gynecologic Oncology (JSGO)

Kobayashi Y, Masuda K, Hiraswa A, Takehara K, Tsuda H, Watanabe Y, Oda K, Nagase S, Mandai M, Okamoto A, Yaegashi N, Mikami M, Enomoto T, Aoki D, Katabuchi H; Working Group on Clinical Practice for Cancer Genomic Medicine and HBOC, Japan Society of Gynecologic Oncology

J Gynecol Oncol 33 ( 5 ) e61 2022.09

Joint Work

Climacteric symptoms in postoperative patients among endometrial cancer, cervical cancer, and ovarian cancer: a cross-sectional study

Horiba Y, Yoshino T, Yokota M, Iwata T, Watanabe K, Mimura M, Aoki D

Support Care Cancer 30 ( 8 ) 6785 - 6793 2022.08

Research paper (scientific journal), Joint Work, Accepted

Considerations in performing hysterectomy secondary to uterus transplantation

Kisu I, Banno K, Aoki D

Acta Obstet Gynecol Scand 101 ( 8 ) 933 - 934 2022.08

Research paper (scientific journal), Joint Work

Characteristics and clinicopathological features of patients with ovarian metastasis of endometrial cancer: a retrospective study.

Matoba Y, Yamagami W, Chiyoda T, Kobayashi Y, Tominaga E, Banno K, Aoki D

J Obstet Gynaecol 42 ( 6 ) 2456 - 2462 2022.08

Research paper (scientific journal), Joint Work, Last author

TP53 variants in p53signatures and the clonality of STICs in RRSO samples

Akahane T, Masuda K, Hirasawa A, Kobayashi Y, Ueki A, Kawaida M, Misu K, Nakamura K, Nagai S, Chiyoda T, Yamagami W, Hayashi S, Kataoka F, Banno K, Sugano K, Okita H, Kosaki K, Nishihara H, Aoki D

J Gynecol Oncol 33 ( 4 ) e50 2022.07

Research paper (scientific journal), Joint Work, Last author

子宮頸部上皮内病変（CIN）に対してレーザー蒸散術後に子宮頸がんと診断された18例の検討

田中郁百，西尾 浩，岩田 卓，大野あゆみ，谷本慧子，横田めぐみ，田中 守，青木大輔

東京産科婦人科学会会誌 71 ( 3 ) 447 - 451 2022.07

Research paper (scientific journal), Joint Work, Last author, Accepted

当院におけるMayer-Rokitansky-Küster-Hauser症候群17例の診療経験

三宅温子，小林佑介，今枝慶蓉，吉浜智子，横田めぐみ，林 茂徳，山上 亘，阪埜浩司，田中　守，青木大輔

東京産科婦人科学会会誌 71 ( 3 ) 436 - 440 2022.07

Research paper (scientific journal), Joint Work, Last author, Accepted

Keio Uterus Transplantation Research: From Basic Research toward Future Clinical Application

Kisu I, Banno K, Matoba Y, Yamada Y, Emoto K, Masugi Y, Matsubara K, Obara H, Aoki D

Keio J Med 71 ( 2 ) 33 - 43 2022.06

Research paper (bulletin of university, research institution), Joint Work, Last author, Accepted

女性の抑うつに漢方薬が効果を認めた2症例

谷本慧子，横田めぐみ，大野あゆみ，弟子丸亮太，堀場裕子，青木大輔

産婦人科漢方研究のあゆみ 38   113 - 116 2022.05

Research paper (scientific journal), Joint Work, Last author

Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling

Komatsu M, Nakamura K, Takeda T, Chiwaki F, Banno K, Aoki D, Takeshita F, Sasaki H

Oncogene 41 ( 16 ) 2326 - 2339 2022.04

Research paper (scientific journal), Joint Work

切迫早産管理中に肺血栓塞栓症を発症した1例

緒方 恵，田中雄也，春日義史，内田志穂，明石一浩，池ノ上 学，西尾 浩，落合大吾，青木大輔，田中 守

東京産科婦人科学会会誌 71 ( 2 ) 349 - 354 2022.04

Research paper (scientific journal), Joint Work, Accepted

Status of cervical cancer screening among adolescents and young adults (AYA) in Japan

Saitoh E, Saika K, Morisada T, Aoki D

Int J Clin Oncol 27 ( 3 ) 473 - 480 2022.03

Research paper (scientific journal), Joint Work, Last author

Correction to: Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2

Tozawa, A., Kimura, F., Takai, Y., Nakajima, T., Ushijima, K., Kobayashi, H., Satoh, T., Harada, M., Sugimoto, K., Saji, S., Shimizu, C., Akiyama, K., Bando, H., Kuwahara, A., Furui, T., Okada, H., Kawai, K., Shinohara, N., Nagao, K., Kitajima, M., Suenobu, S., Soejima, T., Miyachi, M., Miyoshi, Y., Yoneda, A., Horie, A., Ishida, Y., Usui, N., Kanda, Y., Fujii, N., Endo, M., Nakayama, R., Hoshi, M., Yonemoto, T., Kiyotani, C., Okita, N., Baba, E., Muto, M., Kikuchi, I., Morishige, K. I., Tsugawa, K., Nishiyama, H., Hosoi, H., Tanimoto, M., Kawai, A., Sugiyama, K., Boku, N., Yonemura, M., Hayashi, N., Aoki, D., Suzuki, N. and Osuga, Y.

Int J Clin Oncol 27 ( 3 ) 635 - 637 2022.03

Research paper (scientific journal), Joint Work,  ISSN  1341-9625

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Clinical Usefulness of Endometrial Cytology in Determining the Therapeutic Effect of Fertility Preserving Therapy

Yoshimura, T., Yamagami, W., Takahashi, M., Hirano, T., Sakai, K., Makabe, T., Chiyoda, T., Banno, K. and Aoki, D.

Acta Cytol 66 ( 2 ) 106 - 113 2022.03

Research paper (scientific journal), Joint Work,  ISSN  0001-5547

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INTRODUCTION: The significance of endometrial cytology in determining the therapeutic efficacy of medroxyprogesterone acetate (MPA) therapy is unclear. This study aimed to evaluate the clinical usefulness of endometrial cytology during MPA therapy. METHODS: Overall, 77 patients who underwent dilatation and curettage (D&C) to evaluate the therapeutic efficacy of MPA therapy at our hospital between January 2018 and December 2019 were retrospectively analyzed. The results of D&C, cytological evaluation, and other clinicopathological factors were analyzed based on the patients' medical records. RESULTS: The sensitivity and specificity of cytology were 61% and 92%, respectively, with D&C being the gold standard for diagnosis in 142 D&C/cytological examinations. Among patients with no residual disease on D&C, 5 (4%) had suspicious or positive cytology. Although MPA therapy was terminated in 3 of these patients, only 1 patient had early recurrence, and the frequency of recurrence was similar to that of patients who showed negative results in both D&C and cytology. DISCUSSION/CONCLUSION: The sensitivity of endometrial cytology in determining the therapeutic effect of MPA therapy is low, and we confirmed that the omission of D&C is unacceptable. Our findings also suggested that the addition of cytological evaluation to D&C during MPA therapy had a low clinical significance.

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Clinical and pathological analysis of companion diagnostic testing of microsatellite instability-high for pembrolizumab in gynaecologic malignancy

Takeda, T., Tsuji, K., Kobayashi, Y., Banno, K. and Aoki, D.

Jpn J Clin Oncol 52 ( 2 ) 128 - 133 2022.02

ISSN  0368-2811

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BACKGROUND: Microsatellite instability-high is a known biomarker for anti-PD-1/PD-L1 immune checkpoint therapy. It is also a known tumour feature of Lynch syndrome, detected most frequently in endometrial cancer. However, it remains unclear how microsatellite instability testing is carried out in the clinical field. METHODS: Ninety-nine patients with gynaecological malignant tumours who underwent microsatellite instability testing as a companion diagnosis for pembrolizumab and 16 patients who previously underwent microsatellite instability testing as a screening for Lynch syndrome were recruited. Clinical information, microsatellite instability status, outcomes, genetic assessments and information about cancer tissue were retrospectively analysed. RESULTS: Ninety-nine patients had 101 gynaecologic malignant tumours including 26 endometrial, 38 ovarian and 28 cervical cancers, 9 with other tumours including 2 synchronous endometrial and ovarian cancers. All tissue samples were successfully tested, even though some were ≥10-year-old samples. Three cases (3.0%, 3/99) showed microsatellite instability-high; all cases were endometrial cancers with one case of synchronous endometrial and ovarian cancer [11.5% (3/26) in endometrial cancer, 2.6% (1/38) in ovarian cancer], and there was no microsatellite instability-high in cervical and other cancers. One of the endometrial cancer patients received pembrolizumab treatment, but finally died of cancer. Two other cases underwent genetic testing; both were diagnosed as Lynch syndrome. Six cases (37.5%) showed microsatellite instability-high in screening for Lynch syndrome. CONCLUSIONS: Microsatellite instability-high was less commonly detected as a companion diagnosis for pembrolizumab in unselected gynaecologic patients. Genetic counselling should be always provided along with treatment selection.

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