Papers - Aoki, Daisuke

妊娠初期における脳瘤の検出を契機にMeckel-Gruber症候群と胎内診断した1例

AOKI DAISUKE

東京産科婦人科学会会誌 64 ( 4 ) 591 - 595 2015.10

Joint Work

Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment

Kiba, A., Banno, K., Yanokura, M., Asada, M., Nakayama, Y., Aoki, D. and Watanabe, T.

J Obstet Gynaecol Res 41 ( 10 ) 1598 - 606 2015.10

ISSN  1447-0756

• Access to Document (DOI)

脂質異常症治療薬スタチンが抗悪性腫瘍薬となる未来

AOKI DAISUKE

産科と婦人科 82 ( 10 ) 1125 - 1129 2015.10

Joint Work

How do Japanese gynecologists view hormone replacement therapy for survivors of endometrial cancer? Japanese Gynecologic Oncology Group (JGOG) survey

Yokoyama, Y., Ito, K., Takamatsu, K., Takehara, K., Nakanishi, T., Harano, K., Watari, H., Susumu, N., Aoki, D. and Saito, T.

Int J Clin Oncol 20 ( 5 ) 997 - 1004 2015.10

ISSN  1341-9625

　View Summary

BACKGROUND: This survey sought to determine Japanese gynecologists' attitudes concerning administering hormone replacement therapy (HRT) for patients after surgery for endometrial cancer (EC). METHODS: Eight hundred and eighty-eight members of the Japanese Gynecologic Oncology Group (JGOG) were asked to respond to an anonymous questionnaire on the JGOG website. The survey asked whether or not HRT was to be administered when surgery was performed (including a hysterectomy and bilateral oophorectomy) to treat EC before or after menopause. If HRT was not to be administered, respondents were asked the reason why. Respondents were presented with the same hypothetical patients that were featured in a previous survey in Germany, and differences in the mindsets of Japanese and German physicians were compared. RESULTS: Responses from 363 individuals (response rate 40.9 %) were analyzed. Seventy-eight percent of physicians considered HRT for patients undergoing surgery before menopause. The most prevalent reason of refusal to prescribe HRT was the risk of EC recurrence. Forty-eight percent of physicians considered HRT for patients undergoing surgery after menopause. The most prevalent reasons of refusal of HRT were its limited benefit and the availability of alternative therapies. Sixty-five percent of Japanese physicians responded that they would administer HRT to patients with low risk of recurrence vs. 46 % of physicians in Germany (P < 0.0002). Forty-nine percent of Japanese physicians approved of prescribing HRT for patients with high risk of recurrence vs. 25 % of physicians in Germany (P < 0.0001). CONCLUSION: Many Japanese gynecologists have a favorable attitude toward prescribing HRT after treatment of EC.

• Access to Document (DOI)

術後感染症リンパ嚢胞の治療方法に関する検討

AOKI DAISUKE

東京産科婦人科学会会誌 64 ( 4 ) 571 - 575 2015.10

Joint Work

子宮体がんの予防とヘルスケア

AOKI DAISUKE

産婦人科の実際　女性ヘルスケア　集中講義！ 61 ( 10月臨時増刊号 ) 399 - 408 2015.10

Joint Work

Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women

Yokota, M., Hirasawa, A., Makita, K., Akahane, T., Sakai, K., Makabe, T., Horiba, Y., Yamagami, W., Ogawa, M., Iwata, T., Yanamoto, S., Deshimaru, R., Banno, K., Susumu, N. and Aoki, D.

Prz Menopauzalny 14 ( 3 ) 161 - 7 2015.09

ISSN  1643-8876

　View Summary

INTRODUCTION: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. MATERIAL AND METHODS: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. RESULTS: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. CONCLUSIONS: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.

• Access to Document (DOI)

High Expression of p62 Protein Is Associated with Poor Prognosis and Aggressive Phenotypes in Endometrial Cancer

Iwadate, R., Inoue, J., Tsuda, H., Takano, M., Furuya, K., Hirasawa, A., Aoki, D. and Inazawa, J.

Am J Pathol 185 ( 9 ) 2523 - 33 2015.09

ISSN  1525-2191

• Access to Document (DOI)

A surgical technique using the ovarian vein in non-human primate models of potential living-donor surgery of uterus transplantation

Kisu, I., Banno, K., Mihara, M., Hara, H., Umene, K., Adachi, M., Nogami, Y. and Aoki, D.

Acta Obstet Gynecol Scand 94 ( 9 ) 942 - 8 2015.09

ISSN  1600-0412

Prevalence and differentiation of hereditary breast and ovarian cancers in Japan

Nakamura, S., Takahashi, M., Tozaki, M., Nakayama, T., Nomizu, T., Miki, Y., Murakami, Y., Aoki, D., Iwase, T., Nishimura, S., Yamauchi, H., Ohsumi, S., Baba, S. and Shimizu, T.

Breast Cancer 22 ( 5 ) 462 - 8 2015.09

Joint Work,  ISSN  1880-4233

• Access to Document (DOI)

Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer

Suemori, T., Susumu, N., Iwata, T., Banno, K., Yamagami, W., Hirasawa, A., Sugano, K., Matsumoto, E. and Aoki, D.

Int J Gynecol Cancer 25 ( 7 ) 1165 - 72 2015.09

ISSN  1525-1438

• Access to Document (DOI)

ⅠB1期への広汎性子宮頸部摘出術

AOKI DAISUKE

臨床婦人科産科 69 ( 9 ) 826 - 830 2015.09

Joint Work

遺伝性乳癌・卵巣癌

AOKI DAISUKE

臨床画像 31 ( 10 増刊号 ) 220 - 221 2015.09

Joint Work

東京都の子宮頸がん検診の精度管理について

AOKI DAISUKE

東京都医師会雑誌 68 ( 8 ) 15 - 18 2015.09

Single Work

家族性腫瘍としての子宮内膜癌

AOKI DAISUKE

日本臨床　家族性腫瘍学－家族性腫瘍の最新研究動向－ 73 ( 増刊号6 ) 467 - 470 2015.08

Joint Work

子宮頸癌に対する同時化学放射線療法後に生じた晩期有害事象の検討

AOKI DAISUKE

東京産科婦人科学会会誌 64 ( 3 ) 349 - 353 2015.07

Joint Work

Absence of lactobacilli containing glycolipids with the alpha-galactose epitope and the enhanced fucosylation of a receptor glycolipid GA1 in the digestive tracts of immune-deficient scid mice

Iwamori, M., Tanaka, K., Adachi, S., Aoki, D. and Nomura, T.

J Biochem 158 ( 1 ) 73 - 82 2015.07

ISSN  1756-2651

• Access to Document (DOI)

BRCA1/2遺伝子変死保持者に対するリスク低減卵管卵巣摘出術とサーベイランス

AOKI DAISUKE

産科と婦人科 82 ( 6 ) 639 - 642 2015.06

Joint Work

Effects of chemotherapy on patients with recurrent cervical cancer previously treated with concurrent chemoradiotherapy: a retrospective multicenter survey in Japan

Tokunaga H, Nakanishi T, Iwata T, Aoki D, Saito T, Nagase S, Takahashi F, Yaegashi N, Watanabe Y

Int J Clin Oncol 20 ( 3 ) 561 - 565 2015.06

Research paper (scientific journal), Joint Work

CT画像より得られた膀胱側腔、直腸側腔の画像情報をもとに考察した広汎子宮全摘出術

AOKI DAISUKE

産婦人科手術 26   71 - 78 2015.06

Joint Work