Details of a Researcher - Aoki, Daisuke

Papers - Aoki, Daisuke

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Living donor surgery in uterus transplantation: A delicate hysterectomy technique in gynecological surgery

Kisu I, Banno K, Aoki D

J Obstet Gynaecol Res 48 ( 10 ) 2652 - 2653 2022.10

Research paper (scientific journal), Last author

Efficacy and safety of olaparib maintenance monotherapy for Japanese patients with platinum-sensitive relapsed ovarian, fallopian tube, and primary peritoneal cancer

Yoshihama T, Kuroda Y, Chiyoda T, Takahashi M, Yoshimura T, Saotome K, Nanki Y, Sakai K, Kobayashi Y, Yamagami W, Aoki D

Int J Clin Oncol 27 ( 10 ) 1644 - 1650 2022.10

Research paper (scientific journal), Last author

Development of a prognostic prediction support system for cervical intraepithelial neoplasia using artificial intelligence-based diagnosis

Takahashi T, Matsuoka H, Sakurai R, Akatsuka J, Kobayashi Y, Nakamura M, Iwata T, Banno K, Matsuzaki M, Takayama J, Aoki D, Yamamoto Y, Tamiya G

J Gynecol Oncol 33 ( 5 ) e57 2022.09

Research paper (scientific journal), Joint Work

Current status of hereditary breast and ovarian cancer practice among gynecologic oncologists in Japan: a nationwide survey by the Japan Society of Gynecologic Oncology (JSGO)

Kobayashi Y, Masuda K, Hiraswa A, Takehara K, Tsuda H, Watanabe Y, Oda K, Nagase S, Mandai M, Okamoto A, Yaegashi N, Mikami M, Enomoto T, Aoki D, Katabuchi H; Working Group on Clinical Practice for Cancer Genomic Medicine and HBOC, Japan Society of Gynecologic Oncology

J Gynecol Oncol 33 ( 5 ) e61 2022.09

Research paper (scientific journal)

Incidence of fistula occurrence in patients with cervical cancer treated with bevacizumab: data from real-world clinical practice

Sugiyama T, Katsumata N, Toita T, Ura M, Shimizu A, Kamijima S, Aoki D

Int J Clin Oncol 27 ( 9 ) 1517 - 1528 2022.09

Research paper (scientific journal), Joint Work, Last author

Current status of hereditary breast and ovarian cancer practice among gynecologic oncologists in Japan: a nationwide survey by the Japan Society of Gynecologic Oncology (JSGO)

J Gynecol Oncol 33 ( 5 ) e61 2022.09

Joint Work

Climacteric symptoms in postoperative patients among endometrial cancer, cervical cancer, and ovarian cancer: a cross-sectional study

Horiba Y, Yoshino T, Yokota M, Iwata T, Watanabe K, Mimura M, Aoki D

Support Care Cancer 30 ( 8 ) 6785 - 6793 2022.08

Research paper (scientific journal), Joint Work, Accepted

Considerations in performing hysterectomy secondary to uterus transplantation

Kisu I, Banno K, Aoki D

Acta Obstet Gynecol Scand 101 ( 8 ) 933 - 934 2022.08

Research paper (scientific journal), Joint Work

Characteristics and clinicopathological features of patients with ovarian metastasis of endometrial cancer: a retrospective study.

Matoba Y, Yamagami W, Chiyoda T, Kobayashi Y, Tominaga E, Banno K, Aoki D

J Obstet Gynaecol 42 ( 6 ) 2456 - 2462 2022.08

Research paper (scientific journal), Joint Work, Last author

TP53 variants in p53signatures and the clonality of STICs in RRSO samples

Akahane T, Masuda K, Hirasawa A, Kobayashi Y, Ueki A, Kawaida M, Misu K, Nakamura K, Nagai S, Chiyoda T, Yamagami W, Hayashi S, Kataoka F, Banno K, Sugano K, Okita H, Kosaki K, Nishihara H, Aoki D

J Gynecol Oncol 33 ( 4 ) e50 2022.07

Research paper (scientific journal), Joint Work, Last author

子宮頸部上皮内病変（CIN）に対してレーザー蒸散術後に子宮頸がんと診断された18例の検討

田中郁百，西尾浩，岩田卓，大野あゆみ，谷本慧子，横田めぐみ，田中守，青木大輔

東京産科婦人科学会会誌 71 ( 3 ) 447 - 451 2022.07

Research paper (scientific journal), Joint Work, Last author, Accepted

当院におけるMayer-Rokitansky-Küster-Hauser症候群17例の診療経験

三宅温子，小林佑介，今枝慶蓉，吉浜智子，横田めぐみ，林茂徳，山上亘，阪埜浩司，田中　守，青木大輔

東京産科婦人科学会会誌 71 ( 3 ) 436 - 440 2022.07

Research paper (scientific journal), Joint Work, Last author, Accepted

Keio Uterus Transplantation Research: From Basic Research toward Future Clinical Application

Kisu I, Banno K, Matoba Y, Yamada Y, Emoto K, Masugi Y, Matsubara K, Obara H, Aoki D

Keio J Med 71 ( 2 ) 33 - 43 2022.06

Research paper (bulletin of university, research institution), Joint Work, Last author, Accepted

女性の抑うつに漢方薬が効果を認めた2症例

谷本慧子，横田めぐみ，大野あゆみ，弟子丸亮太，堀場裕子，青木大輔

産婦人科漢方研究のあゆみ 38 113 - 116 2022.05

Research paper (scientific journal), Joint Work, Last author

Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling

Komatsu M, Nakamura K, Takeda T, Chiwaki F, Banno K, Aoki D, Takeshita F, Sasaki H

Oncogene 41 ( 16 ) 2326 - 2339 2022.04

Research paper (scientific journal), Joint Work

切迫早産管理中に肺血栓塞栓症を発症した1例

緒方恵，田中雄也，春日義史，内田志穂，明石一浩，池ノ上学，西尾浩，落合大吾，青木大輔，田中守

東京産科婦人科学会会誌 71 ( 2 ) 349 - 354 2022.04

Research paper (scientific journal), Joint Work, Accepted

Status of cervical cancer screening among adolescents and young adults (AYA) in Japan

Saitoh E, Saika K, Morisada T, Aoki D

Int J Clin Oncol 27 ( 3 ) 473 - 480 2022.03

Research paper (scientific journal), Joint Work, Last author

Correction to: Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2

Tozawa, A., Kimura, F., Takai, Y., Nakajima, T., Ushijima, K., Kobayashi, H., Satoh, T., Harada, M., Sugimoto, K., Saji, S., Shimizu, C., Akiyama, K., Bando, H., Kuwahara, A., Furui, T., Okada, H., Kawai, K., Shinohara, N., Nagao, K., Kitajima, M., Suenobu, S., Soejima, T., Miyachi, M., Miyoshi, Y., Yoneda, A., Horie, A., Ishida, Y., Usui, N., Kanda, Y., Fujii, N., Endo, M., Nakayama, R., Hoshi, M., Yonemoto, T., Kiyotani, C., Okita, N., Baba, E., Muto, M., Kikuchi, I., Morishige, K. I., Tsugawa, K., Nishiyama, H., Hosoi, H., Tanimoto, M., Kawai, A., Sugiyama, K., Boku, N., Yonemura, M., Hayashi, N., Aoki, D., Suzuki, N. and Osuga, Y.

Int J Clin Oncol 27 ( 3 ) 635 - 637 2022.03

Research paper (scientific journal), Joint Work, ISSN 1341-9625

Access to Document (DOI)

Clinical Usefulness of Endometrial Cytology in Determining the Therapeutic Effect of Fertility Preserving Therapy

Yoshimura, T., Yamagami, W., Takahashi, M., Hirano, T., Sakai, K., Makabe, T., Chiyoda, T., Banno, K. and Aoki, D.

Acta Cytol 66 ( 2 ) 106 - 113 2022.03

Research paper (scientific journal), Joint Work, ISSN 0001-5547

INTRODUCTION: The significance of endometrial cytology in determining the therapeutic efficacy of medroxyprogesterone acetate (MPA) therapy is unclear. This study aimed to evaluate the clinical usefulness of endometrial cytology during MPA therapy. METHODS: Overall, 77 patients who underwent dilatation and curettage (D&C) to evaluate the therapeutic efficacy of MPA therapy at our hospital between January 2018 and December 2019 were retrospectively analyzed. The results of D&C, cytological evaluation, and other clinicopathological factors were analyzed based on the patients' medical records. RESULTS: The sensitivity and specificity of cytology were 61% and 92%, respectively, with D&C being the gold standard for diagnosis in 142 D&C/cytological examinations. Among patients with no residual disease on D&C, 5 (4%) had suspicious or positive cytology. Although MPA therapy was terminated in 3 of these patients, only 1 patient had early recurrence, and the frequency of recurrence was similar to that of patients who showed negative results in both D&C and cytology. DISCUSSION/CONCLUSION: The sensitivity of endometrial cytology in determining the therapeutic effect of MPA therapy is low, and we confirmed that the omission of D&C is unacceptable. Our findings also suggested that the addition of cytological evaluation to D&C during MPA therapy had a low clinical significance.

Access to Document (DOI)

Clinical and pathological analysis of companion diagnostic testing of microsatellite instability-high for pembrolizumab in gynaecologic malignancy

Takeda, T., Tsuji, K., Kobayashi, Y., Banno, K. and Aoki, D.

Jpn J Clin Oncol 52 ( 2 ) 128 - 133 2022.02

ISSN 0368-2811

BACKGROUND: Microsatellite instability-high is a known biomarker for anti-PD-1/PD-L1 immune checkpoint therapy. It is also a known tumour feature of Lynch syndrome, detected most frequently in endometrial cancer. However, it remains unclear how microsatellite instability testing is carried out in the clinical field. METHODS: Ninety-nine patients with gynaecological malignant tumours who underwent microsatellite instability testing as a companion diagnosis for pembrolizumab and 16 patients who previously underwent microsatellite instability testing as a screening for Lynch syndrome were recruited. Clinical information, microsatellite instability status, outcomes, genetic assessments and information about cancer tissue were retrospectively analysed. RESULTS: Ninety-nine patients had 101 gynaecologic malignant tumours including 26 endometrial, 38 ovarian and 28 cervical cancers, 9 with other tumours including 2 synchronous endometrial and ovarian cancers. All tissue samples were successfully tested, even though some were ≥10-year-old samples. Three cases (3.0%, 3/99) showed microsatellite instability-high; all cases were endometrial cancers with one case of synchronous endometrial and ovarian cancer [11.5% (3/26) in endometrial cancer, 2.6% (1/38) in ovarian cancer], and there was no microsatellite instability-high in cervical and other cancers. One of the endometrial cancer patients received pembrolizumab treatment, but finally died of cancer. Two other cases underwent genetic testing; both were diagnosed as Lynch syndrome. Six cases (37.5%) showed microsatellite instability-high in screening for Lynch syndrome. CONCLUSIONS: Microsatellite instability-high was less commonly detected as a companion diagnosis for pembrolizumab in unselected gynaecologic patients. Genetic counselling should be always provided along with treatment selection.

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A retrospective study for investigating the outcomes of endometrial cancer treated with radiotherapy

Sakai K, Yamagami W, Machida H, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Aoki D, Mikami M

Int J Gynaecol Obstet 156 ( 2 ) 262 - 269 2022.02

Research paper (scientific journal), Joint Work, Accepted

Ancient Evolutionary History of Human Papillomavirus Type 16, 18 and 58 Variants Prevalent Exclusively in Japan

Tanaka K, Kogure G, Onuki M, Matsumoto K, Iwata T, Aoki D, Kukimoto I

Viruses 4 ( 3 ) 464 2022.02

Research paper (scientific journal), Joint Work

Prospective feasibility study of neoadjuvant dose-dense paclitaxel plus carboplatin with bevacizumab therapy followed by interval debulking surgery for advanced ovarian, fallopian tube, and primary peritoneal cancer patients

Iwasa-Inoue, N., Nomura, H., Kataoka, F., Chiyoda, T., Yoshihama, T., Nanki, Y., Sakai, K., Kobayashi, Y., Yamagami, W., Morisada, T., Hirasawa, A. and Aoki, D.

Int J Clin Oncol (International Journal of Clinical Oncology) 27 ( 2 ) 441 - 447 2022.02

Research paper (scientific journal), ISSN 13419625

BACKGROUND: This study aimed to investigate the clinical benefit of dose-dense paclitaxel plus carboplatin (TC) with bevacizumab therapy for advanced ovarian, fallopian tube, and primary peritoneal cancer patients in the neoadjuvant setting. METHODS: Ovarian, fallopian tube or primary peritoneal cancer patients with stage III-IV disease received neoadjuvant chemotherapy (NAC) every 3 weeks consisting of paclitaxel (80 mg/m(2)) on days 1, 8, and 15; carboplatin (AUC 6.0 mg/mL × min.) on day 1; and bevacizumab (15 mg/kg) on day 1. Interval debulking surgery (IDS) was performed after 3 cycles of dose-dense TC-bevacizumab therapy. The primary endpoint was the rate of complete resection by IDS. Secondary endpoints were treatment completion rate, treatment exposure, response rate to NAC, adverse events, and perioperative complications. RESULTS: Twenty-four patients were included in this study. The median age was 55.5 years (37-80 years), and most patients had high-grade serous carcinoma accounted (n = 18). IDS was performed in all patients with complete resection achieved in 75% (95% confidence interval: 57.7-92.3%). The lower limit exceeded the preset threshold rate of 55%. The response rate to NAC was 79%, and serum CA125 levels were in the normal range after NAC in 57% of patients. Grade 4 hematological toxicities and grade 3/4 non-hematological toxicities occurred in 29% and 17% of patients during NAC, respectively. Grade 3/4 perioperative complications were seen in 29% of patients, but no gastrointestinal perforations or treatment-related deaths occurred. CONCLUSIONS: Neoadjuvant dose-dense TC-bevacizumab therapy was well tolerated, and a satisfactory rate of complete resection by IDS was achieved.

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Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2

Int J Clin Oncol 27 ( 2 ) 281 - 300 2022.02

ISSN 1341-9625

The Japan Society of Clinical Oncology (JSCO) published the "JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients" in 2017. This was the first guideline in cancer reproductive medicine in Japan. In the field of cancer reproductive medicine, close cooperation between an oncologist and a physician for reproductive medicine is important from before treatment initiation until long after treatment. The guideline takes into consideration disease specificity and provides opinions from the perspective of oncologists and specialists in reproductive medicine that are in line with the current state of the Japanese medical system. It is intended to serve as a reference for medical staff in both fields regarding the availability of fertility preservation therapy before the start of cancer treatment. Appropriate use of this guideline makes it easier to determine whether fertility preservation therapy is feasible and, ultimately, to improve survivorship in childhood, adolescent, and young adult cancer patients. In this article (Part 2), we describe details by organ/system and also for pediatric cancer.

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Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 1

Harada, M., Kimura, F., Takai, Y., Nakajima, T., Ushijima, K., Kobayashi, H., Satoh, T., Tozawa, A., Sugimoto, K., Saji, S., Shimizu, C., Akiyama, K., Bando, H., Kuwahara, A., Furui, T., Okada, H., Kawai, K., Shinohara, N., Nagao, K., Kitajima, M., Suenobu, S., Soejima, T., Miyachi, M., Miyoshi, Y., Yoneda, A., Horie, A., Ishida, Y., Usui, N., Kanda, Y., Fujii, N., Endo, M., Nakayama, R., Hoshi, M., Yonemoto, T., Kiyotani, C., Okita, N., Baba, E., Muto, M., Kikuchi, I., Morishige, K. I., Tsugawa, K., Nishiyama, H., Hosoi, H., Tanimoto, M., Kawai, A., Sugiyama, K., Boku, N., Yonemura, M., Hayashi, N., Aoki, D., Osuga, Y. and Suzuki, N.

Int J Clin Oncol 27 ( 2 ) 265 - 280 2022.02

ISSN 1341-9625

In 2017, the Japan Society of Clinical Oncology (JSCO) published the JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients. These were the first Japanese guidelines to address issues of oncofertility. In this field of medicine, sustained close cooperation between oncologists and reproductive specialists is essential from the diagnosis of cancer until many years after completion of cancer treatment. These JSCO guidelines were intended to guide multidisciplinary medical staff in considering the availability of fertility preservation options and to help them decide whether to provide fertility preservation to childhood, adolescent, and young adult cancer patients before treatment starts, with the ultimate goal of improving patient survivorship. The guidelines are presented as Parts 1 and 2. This article (Part 1) summarizes the goals of the guidelines and the methods used to develop them and provides an overview of fertility preservation across all oncology areas. It includes general remarks on the basic concepts surrounding fertility preservation and explanations of the impacts of cancer treatment on gonadal function by sex and treatment modality and of the options for protecting/preserving gonadal function and makes recommendations based on 4 clinical questions. Part 2 of these guidelines provides specific recommendations on fertility preservation in 8 types of cancer (gynecologic, breast, urologic, pediatric, hematologic, bone and soft tissue, brain, and digestive).

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Response Predictive Markers and Synergistic Agents for Drug Repositioning of Statins in Ovarian Cancer

Kobayashi, Y., Takeda, T., Kunitomi, H., Chiwaki, F., Komatsu, M., Nagai, S., Nogami, Y., Tsuji, K., Masuda, K., Ogiwara, H., Sasaki, H., Banno, K. and Aoki, D.

Pharmaceuticals (Basel) 15 ( 2 ) 2022.01

ISSN 1424-8247

In the field of drug repurposing, the use of statins for treating dyslipidemia is considered promising in ovarian cancer treatment based on epidemiological studies and basic research findings. Biomarkers should be established to identify patients who will respond to statin treatment to achieve clinical application. In the present study, we demonstrated that statins have a multifaceted mode of action in ovarian cancer and involve pathways other than protein prenylation. To identify biomarkers that predict the response to statins, we subjected ovarian cancer cells to microarray analysis and calculated Pearson's correlation coefficients between gene expression and cell survival after statin treatment. The results showed that VDAC1 and LDLRAP1 were positively and negatively correlated with the response to statins, respectively. Histoculture drug response assays revealed that statins were effective in clinical samples. We also confirmed the synergistic effects of statins with paclitaxel and panobinostat and determined that statins are hematologically safe to administer to statin-treated mice. Future clinical trials based on the expression of the biomarkers identified in this study for repurposing statins for ovarian cancer treatment are warranted.

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Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study

Watanabe K, Iida M, Harada S, Kato S, Kuwabara K, Kurihara A, Takeuchi A, Sugiyama D, Okamura T, Suzuki A, Amano K, Hirayama A, Sugimoto M, Soga T, Tomita M, Kobayashi Y, Banno K, Aoki D, Takebayashi T

Maturitas 155 54 - 62 2022.01

Research paper (scientific journal), Joint Work, Accepted

HPV検査単独法を念頭においた場合に実施すべき子宮頸がん検診体制について

齊藤英子，雑賀公美子，森定徹，宮城悦子，藤井多久磨，高橋宏和，八重樫伸生，戸澤晃子，中山富雄，青木大輔

日本がん検診・診断学会誌 29 ( 3 ) 185 - 192 2022.01

Research paper (scientific journal), Joint Work

Association between hospital treatment volume and survival of women with gynecologic malignancy in Japan: a JSOG tumor registry-based data extraction study

Machida H, Matsuo K, Oba K, Aoki D, Enomoto T, Okamoto A, Katabuchi H, Nagase S, Mandai M, Yaegashi N, Yamagami W, Mikami M

J Gynecol Oncol 33 ( 1 ) e3 2022.01

Research paper (scientific journal), Joint Work, Accepted

Endometrial cancer

Makker V, MacKay H, Ray-Coquard I, Levine DA, Westin SN, Aoki D, Oaknin A

Nat Rev Dis Primers 7 ( 1 ) 88 2021.12

Research paper (scientific journal), Joint Work

Surveillance of radical hysterectomy for early-stage cervical cancer in the early experienced period of minimally invasive surgery in Japan

Ohta T, Nagase S, Okui Y, Enomoto T, Yamagami W, Mikami M, Tokunaga H, Ino K, Ushijima K, Shozu M, Tashiro H, Mandai M, Miyamoto S, Morishige KI, Yoshida Y, Yoshino K, Saito T, Kobayashi E, Kobayashi H, Takekuma M, Terai Y, Fujii T, Kanao H, Aoki D, Katabuchi H, Yaegashi N

Int J Clin Oncol 26 ( 12 ) 2318 - 2330 2021.12

Research paper (scientific journal), Joint Work, Accepted

Hysteroscopic treatment assisted by photodynamic diagnosis for atypical polypoid adenomyoma: A report of two cases

Matoba Y, Banno K, Kobayashi Y, Yamagami W, Nakamura M, Kisu I, Aoki D

Photodiagnosis Photodyn Ther 36 102583 2021.12

Research paper (scientific journal), Joint Work

Correction to: The efficacy and safety profile of 2-weekly dosing of bevacizumab-containing chemotherapy for platinum-resistant recurrent ovarian cancer

Sekine M, Enomoto T, Watanabe Y, Katabuchi H, Yaegashi N, Aoki D

Int J Clin Oncol 26 ( 11 ) 2130 2021.11

Research paper (scientific journal), Joint Work

Massive Hemorrhage Due to Cervical Endometriotic Cyst Rupture: Two Case Reports and a Literature Review

Matoba Y, Tsuji K, Morisada T, Takahashi M, Kobayashi Y, Nakamura M, Banno K, Aoki D

Am J Case Rep 22 e934120 2021.11

Research paper (scientific journal), Joint Work

The efficacy and safety profile of 2-weekly dosing of bevacizumab-containing chemotherapy for platinum-resistant recurrent ovarian cancer

Sekine M, Enomoto T, Watanabe Y, Katabuchi H, Yaegashi N, Aoki D

Int J Clin Oncol 26 ( 11 ) 2123 - 2129 2021.11

Research paper (scientific journal), Joint Work, Accepted

Nivolumab Versus Gemcitabine or Pegylated Liposomal Doxorubicin for Patients With Platinum-Resistant Ovarian Cancer: Open-Label, Randomized Trial in Japan (NINJA)

Hamanishi J, Takeshima N, Katsumata N, Ushijima K, Kimura T, Takeuchi S, Matsumoto K, Ito K, Mandai M, Nakai H, Sakuragi N, Watari H, Takahashi N, Kato H, Hasegawa K, Yonemori K, Mizuno M, Takehara K, Niikura H, Sawasaki T, Nakao S, Saito T, Enomoto T, Nagase S, Suzuki N, Matsumoto T, Kondo E, Sonoda K, Aihara S, Aoki Y, Okamoto A, Takano H, Kobayashi H, Kato H, Terai Y, Takazawa A, Takahashi Y, Namba Y, Aoki D, Fujiwara K, Sugiyama T, Konishi I

J Clin Oncol 39 ( 33 ) 3671 - 3681 2021.11

Research paper (scientific journal), Joint Work, Accepted

Usefulness of Endoscopy for Female Genital Plastic Surgery: A Series of 4 Cases with Genital Malformations

Imaeda K, Kobayashi Y, Nakamura K, Hayashi S, Morisada T, Banno K, Aoki D

Am J Case Rep 22 e934363 2021.11

Research paper (scientific journal), Joint Work, Accepted

Cancer of the cervix uteri:2021 update

Bhatla N, Aoki D, Sharma DN, Sankaranarayanan R

Int J Gynaecol Obstet 155 ( Suppl 1 ) 28 - 44 2021.10

Research paper (scientific journal), Joint Work

A phase I study of combined trabectedin and pegylated liposomal doxorubicin therapy for advanced relapsed ovarian cancer

Takahashi S, Takekuma M, Tamura K, Takehara K, Nomura H, Ono M, Yunokawa M,Aoki D

Int J Clin Oncol 26 ( 10 ) 1977 - 1985 2021.10

Research paper (scientific journal), Joint Work, Accepted

A Possible Inhibitory Role of Sialic Acid on MUC1 in Peritoneal Dissemination of Clear Cell-Type Ovarian Cancer Cells

Tamada Y, Nomura H, Aoki D, Irimura T

Molecules 26 ( 19 ) 5962 2021.10

Research paper (scientific journal), Joint Work, Accepted

Incidence of germline variants in Lynch syndrome-related genes among Japanese endometrial cancer patients aged 40 years or younger

Makabe T, Yamagami W, Hirasawa A, Miyabe I, Wakatsuki T, Kikuchi M, Takahashi A, Noda J, Yamamoto G, Aoki D, Akagi K

Int J Clin Oncol 26 ( 9 ) 1767 - 1774 2021.09

Research paper (scientific journal), Joint Work, Accepted

ARID1A mutation/ARID1A loss is associated with a high immunogenic profile in clear cell ovarian cancer

Kuroda Y, Chiyoda T, Kawaida M, Nakamura K, Aimono E, Yoshimura T, Takahashi M, Saotome K, Yoshihama T, Iwasa N, Sakai K, Yamagami W, Nishihara H, Aoki D

Gynecol Oncol 162 ( 3 ) 679 - 685 2021.09

Research paper (scientific journal), Joint Work, Accepted

Transcription Factor Homeobox D9 Drives the Malignant Phenotype of HPV18-Positive Cervical Cancer Cells via Binding to the Viral Early Promoter

Hayashi S, Iwata T, Imagawa R, Sugawara M, Chen G, Tanimoto S, Sugawara Y, Tanaka I, Matsui T, Nishio H, Nakamura M, Katoh Y, Mori S, Kukimoto I, Aoki D

Cancers (Basel) 13 ( 18 ) 4613 2021.09

Research paper (scientific journal), Joint Work, Accepted

Concerns Associated with Uterus Transplantation in Japan

Kisu I, Banno K, Matoba Y, Aoki D

Keio J Med 70 ( 3 ) 68 - 71 2021.09

Research paper (scientific journal), Joint Work, Accepted

腹腔鏡下卵巣嚢腫摘出術を施行しARTをせずに2児を得た卵巣予備能低下の若年重症子宮内膜症の1例

吉政佑之，丸山哲夫，片倉慧美，富里祥子，内田明花，内田浩，田中守，青木大輔

東京産科婦人科学会会誌 70 ( 3 ) 459 - 463 2021.07

Research paper (scientific journal), Joint Work, Accepted

当院で経験した子宮体部大細胞神経内分泌癌（LCNEC）の3例

平松真生子，山上亘，平野卓朗，吉村拓馬，千代田達幸，西尾浩，仲村勝，阪埜浩司，田中守，青木大輔

東京産科婦人科学会会誌 70 ( 3 ) 496 - 497 2021.07

Research paper (scientific journal), Joint Work, Accepted

Evaluating the importance of routine drainage following laparoscopic pelvic lymph node dissection for gynecological malignancies

Sakai K, Nakamura M, Yamagami W, Chiyoda T, Kobayashi Y, Nishio H, Hayashi S, Nomura H, Kataoka F, Tominaga E, Banno K, Aoki D

Int J Gynaecol Obstet 153 ( 3 ) 438 - 442 2021.06

Research paper (scientific journal), Joint Work, Accepted

Evaluation of preoperative prediction of intestinal invasion in patients with ovarian cancer

Takeda T, Hayashi S, Kobayashi Y, Tsuji K, Nagai S, Tominaga E, Suzuki T, Okuda S, Banno K, Aoki D

Int J Gynaecol Obstet 153 ( 3 ) 398 - 404 2021.06

Research paper (scientific journal), Joint Work, Accepted

Nucleosome Positioning on Episomal Human Papillomavirus DNA in Cultured Cells

Murakami I, Iwata T, Morisada T, Tanaka K, Aoki D

Pathogens 10 ( 6 ) 772 2021.06

Research paper (scientific journal), Joint Work

Understanding of the position of patients with Mayer-Rokitansky-Küster-Hauser syndrome revealed by uterus transplantation research in Japan

Kisu I, Banno K, Aoki D

J Obstet Gynaecol Res 47 ( 6 ) 2246 2021.06

Research paper (scientific journal), Joint Work

The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee

Ikeda M, Shida M, Shigeta S, Nagase S, Takahashi F, Yamagami W, Katabuchi H, Yaegashi N, Aoki D, Mikami M

J Gynecol Oncol 32 ( 3 ) e44, 2021.05

Research paper (scientific journal), Joint Work

Current Status and Prospects of Immunotherapy for Gynecologic Melanoma. (Review)

Anko M, Kobayashi Y, Banno K, Aoki D

J Pers Med 11 ( 5 ) 403 2021.05

Research paper (scientific journal), Joint Work

Meningitis caused by Listeria monocytogenes in a locally advanced cervical cancer patient with pyometra: A case report

Matoba Y, Nishio H, Sekiguchi K, Uno S, Masuda K, Hiramatsu M, Takahashi M, Oishi M, Uwamino Y, Uchida S, Daté Y, Morisada T, Banno K, Nakahara J, Aoki D

Gynecol Oncol Rep 37 100799 2021.05

Research paper (scientific journal), Joint Work, Accepted

The first-round results of a population-based cohort study of HPV testing in Japanese cervical cancer screening: baseline characteristics, screening results, and referral rate

Kono K, Morisada T, Saika K, Aoki ES, Miyagi E, Ito K, Takahashi H, Nakayama T, Saito H, Aoki D

J Gynecol Oncol 32 ( 3 ) e29 2021.05

Research paper (scientific journal), Joint Work, Accepted

Survey of the clinical practice pattern of using sentinel lymph node biopsy in patients with gynecological cancers in Japan: the Japan Society of Gynecologic Oncology study

Togami S, Kobayashi H, Niikura H, Shimada M, Susumu N, Tanaka T, Terai Y, Nagai T, Baba T, Yahata H, Yamagami W, Yamaguchi K, Yamashita T, Yaegashi N, Katabuchi H, Aoki D

Int J Clin Oncol 26 ( 5 ) 971 - 979 2021.05

Research paper (scientific journal), Joint Work, Accepted

Atypical vessels in hysteroscopy: Usefulness in prediction of malignant diseases in patients treated with tamoxifen

Oka E, Sakai K, Yamagami W, Hirano T, Makabe T, Yoshihama T, Chiyoda T, Kataoka F, Banno K, Aoki D

J Obstet Gynaecol Res 47 ( 4 ) 1510 - 1515 2021.04

Research paper (scientific journal), Joint Work, Accepted

帝王切開術後の腹腔内出血に対し、腹部コンパートメント症候群に準じて治療介入した1例

大石真希，落合大吾，春日義史，田中雄也，玉川真澄，遠藤豊英，佐藤佑，池ノ上学，田中　守，青木大輔

東京産科婦人科学会会誌 70 ( 2 ) 231 - 236 2021.04

Research paper (scientific journal), Joint Work, Accepted

副腎皮質過形成とAZFcの部分欠失を合併した男性不妊症に対して精巣内精子採取術を実施し妊娠に至った1例

高畑海音子，佐藤卓，末岡浩，水口雄貴，上條慎太郎，山田満稔，浜谷敏生，田中守，青木大輔，佐藤　卓

東京産科婦人科学会会誌 70 ( 2 ) 210 - 215 2021.04

Research paper (scientific journal), Joint Work, Accepted

The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer

Tokunaga H, Mikami M, Nagase S, Kobayashi Y, Tabata T, Kaneuchi M, Satoh T, Hirashima Y, Matsumura N, Yokoyama Y, Kawana K, Kyo S, Aoki D, Katabuchi H

J GynecolOncol 32 ( 2 ) e49 2021.03

Research paper (scientific journal), Joint Work, Accepted

Phase 2 single-arm study on the efficacy and safety of niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer

Okamoto A, Kondo E, Nakamura T, Yanagida S, Hamanishi J, Harano K, Hasegawa K, Hirasawa T, Hori K, Komiyama S, Matsuura M, Nakai H, Nakamura H, Sakata J, Tabata T, Takehara K, Takekuma M, Yokoyama Y, Kase Y, Sumino S, Soeda J, Suri A, Aoki D, Sugiyama T

J Gynecol Oncol 32 ( 2 ) e16 2021.03

Research paper (scientific journal), Joint Work, Accepted

Lymphadenectomy issues in endometrial cancer

Konno Y, Asano H, Shikama A, Aoki D, Tanikawa M, Oki A, Horie K, Mitsuhashi A, Kikuchi A, Tokunaga H, Terao Y, Satoh T, Ushijima K, Ishikawa M, Yaegashi N, Watari H

J Gynecol Oncol 32 ( 2 ) e25 2021.03

Research paper (scientific journal), Joint Work, Accepted

Real-world data on microsatellite instability status in various unresectable or metastatic solid tumors

Akagi K, Oki E, Taniguchi H, Nakatani K, Aoki D, Kuwata T, Yoshino T

Cancer Sci 112 ( 3 ) 1105 - 1113 2021.03

Research paper (scientific journal), Joint Work, Accepted

Current status and future directions of ovarian cancer prognostic models

Kobayashi Y, Banno K, Aoki D

J Gynecol Oncol 32 ( 2 ) e34 2021.03

Research paper (scientific journal), Joint Work, Accepted

Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pathogenic variant carriers among a cohort study in a single institution

Kobayashi Y, Hirasawa A, Chiyoda T, Ueki A, Masuda K, Misu K, Kawaida M, Hayashi S, Kataoka F, Banno K, Kosaki K, Aoki D

Jpn J Clin Oncol 51 ( 2 ) 213 - 217 2021.02

Research paper (scientific journal), Joint Work, Accepted

Current status of cancer immunotherapy for gynecologic malignancies

Nishio H, Iwata T, Aoki D

Jpn J Clin Oncol 51 ( 2 ) 167 - 172 2021.02

Research paper (scientific journal), Joint Work, Accepted

Impact of lymphadenectomy on the treatment of endometrial cancer using data from the JSOG cancer registry

Saotome K, Yamagami W, Machida H, Ebina Y, Kobayashi Y, Tabata T, Kaneuchi M, Nagase S, Enomoto T, Aoki D, Mikami M

Obstet Gynecol Sci 64 ( 1 ) 80 - 89 2021.01

Research paper (scientific journal), Joint Work, Accepted

Operative and Clinical Outcomes of Minimally Invasive Living-Donor Surgery on Uterus Transplantation: A Literature Review

Matoba Y, Kisu I, Banno K, Aoki D

J. Clin. Med 10 ( 2 ) 349 2021.01

Research paper (scientific journal), Joint Work, Accepted

Familial pancreatic cancer with PALB2 and NBN pathogenic variants: a case report

Abe K, Ueki A, Urakawa Y, Kitago M, Yoshihama T, Nanki Y, Kitagawa Y, Aoki D, Kosaki K, Hirasawa A

Hered Cancer Clin Pract 19 ( 1 ) 5 2021.01

Research paper (scientific journal), Joint Work, Accepted

A prospective cohort study on the safety and efficacy of bevacizumab combined with chemotherapy in Japanese patients with relapsed ovarian, fallopian tube or primary peritonealcancer

Nanki Y, Nomura H, Iwasa N, Saotome K, Dozen A, Yoshihama T, Hirano T, Hashimoto S, Chiyoda T, Yamagami W, Kataoka F, Aoki D

Jpn J Clin Oncol 51 ( 1 ) 54 - 59 2021.01

Research paper (scientific journal), Joint Work, Accepted

Germline multigene panel testing revealed a BRCA2 pathogenic variant in a patient with suspected Lynch syndrome

Yoshihama T, Hirasawa A, Sugano K, Yoshida T, Ushiama M, Ueki A, Akahane T, Nanki Y, Sakai K, Makabe T, Yamagami W, Susumu N, Kameyama K, Kosaki K, Aoki D

Int Cancer Conf J 10 ( 1 ) 6 - 10 2021.01

Research paper (scientific journal), Joint Work, Last author, Accepted

Tumor-infiltrating lymphocytes predict survival outcomes in patients with cervical cancer treated with concurrent chemoradiotherapy

Ohno A, Iwata T, Katoh Y, Taniguchi S, Tanaka K, Nishio H, Nakamura M, Morisada T, Chen G, Saito M, Yaguchi T, Kawakami Y, Aoki D

Gynecol Oncol 159 ( 2 ) 329 - 334 2020.11

Research paper (scientific journal), Joint Work, Accepted

Experimental techniques for the development of a uterus transplantation model in cynomolgus macaques

Kisu I, Banno K, Obara H, Kato Y, Yamada Y, Matsubara K, Matoba Y, Adachi M, Emoto K, Masugi Y, Saiki Y, Ishigaki H, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Nakagawa K, Shiina T, Aoki D

J Obstet Gynaecol Res 46 ( 11 ) 2251 - 2260 2020.11

Research paper (scientific journal), Joint Work, Accepted

Uterine cervical cancer associated with obstructed hemivagina and ipsilateral renal agenesis (OHVIRA)syndrome: A case report and review of the literature

Oka E, Chiyoda T, Iwata T, Yamagami W, Aoki D

Gynecol Oncol Rep 34 100645 2020.11

Joint Work, Accepted

Current progress of uterus transplantation in Asia

Kisu I, Banno K, Aoki D

J Obstet Gynaecol Res 46 ( 11 ) 2456 - 2456 2020.11

Research paper (scientific journal), Joint Work

Image Segmentation of the Ventricular Septum in Fetal Cardiac Ultrasound Videos Based on Deep Learning Using Time-Series Information

Dozen A, Komatsu M, Sakai A, Komatsu R, Shozu K, Machino H, Yasutomi S, Arakaki T, Asada K, Kaneko S, Matsuoka R, Aoki D, Sekizawa A, Hamamoto R

Biomolecules 10 ( 11 ) E1526 2020.11

Research paper (scientific journal), Joint Work, Accepted

The post-progression survival of patients with recurrent or persistent ovarian clear cell carcinoma: results from a randomized phase III study in JGOG3017/GCIG

Kondo E, Tabata T, Suzuki N, Aoki D, Yahata H, Kotera Y, Tokuyama O, Fujiwara K, Kimura E, Terauchi F, Sumi T, Okamoto A, Yaegashi N, Enomoto T, Sugiyama T

J Gynecol Oncol 31 ( 6 ) e94 2020.11

Research paper (scientific journal), Accepted

First Successful Delivery after Uterus Transplantation in MHC-Defined Cynomolgus Macaques

Kisu I, Kato Y, Masugi Y, Ishigaki H, Yamada Y, Matsubara K, Obara H, Emoto K, Matoba Y, Adachi M, Banno K, Saiki Y, Sasamura T, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Murase M, Tsuchiya H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T

J Clin Med 9 ( 11 ) E3694 2020.11

Research paper (scientific journal), Joint Work, Accepted

MicroRNA‑34b expression enhances chemosensitivity of endometrial cancer cells to paclitaxel

Yanokura M, Banno K, Aoki D

Int J Oncol 57 ( 5 ) 1145 - 1156 2020.11

Research paper (scientific journal), Joint Work, Accepted

Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project

Shigeta S, Shida M, Nagase S, Ikeda M, Takahashi F, Shibata T, Yamagami W, Katabuchi H, Yaegashi N, Aoki D, Mikami M

Gynecol Oncol 159 ( 1 ) 248 - 255 2020.10

Research paper (scientific journal), Joint Work, Accepted

Clinical implications of next-generation sequencing-based panel tests for malignant ovarian tumors

Saotome K, Chiyoda T, Aimono E, Nakamura K, Tanishima S, Nohara S, Okada C, Hayashi H, Kuroda Y, Nomura H, Susumu N, Iwata T, Yamagami W, Kataoka F, Nishihara H, Aoki D

Cancer Med 9 ( 20 ) 7407 - 7417 2020.10

Research paper (scientific journal), Joint Work, Accepted

Evaluation of safety and diagnostic performance for flexible hysteroscopy in 1591 outpatient cases

Kobayashi Y, Tsuji K, Nakamura K, Nagai S, Takahashi T, Kobayashi A, Anko M, Hirano T, Watanabe K, Matoba Y, Kunitomi H, Adachi M, Yamagami W, Tominaga E, Banno K, Aoki D

Jpn J Clin Oncol 50 ( 10 ) 1157 - 1161 2020.10

Research paper (scientific journal), Joint Work, Accepted

Comparison of ThinPrep Integrated Imager-Assisted Screening versus Manual Screening of ThinPrep Liquid-Based Cytology Specimens

Tanaka K, Aoki D, Tozawa-Ono A, Suzuki N, Takamatsu K, Nakamura M, Tsunoda H, Seino S, Kobayashi N, Shirayama T, Takahashi F

Acta Cytol 64 ( 5 ) 486 - 491 2020.09

Research paper (scientific journal), Joint Work, Accepted

Association of gBRCA1/2 mutation locations with ovarian cancer risk in Japanese patients from the CHARLOTTE study

Yoshihara K, Enomoto T, Aoki D, Watanabe Y, Kigawa J, Takeshima N, Inomata H, Hattori K, Jinushi M, Tsuda H, Sugiyama T

Cancer Sci 111 ( 9 ) 3350 - 3358 2020.09

Research paper (scientific journal), Joint Work, Accepted

Study of upfront surgery versus neoadjuvant chemotherapy followed by interval debulking surgery for patients with stage IIIC and IV ovarian cancer, SGOG SUNNY (SOC-2) trial concept

Jiang R, Zhu J, Kim JW, Liu J, Kato K, Kim HS, Zhang Y, Zhang P, Zhu T, Aoki D, Yu A, Chen X, Wang X, Zhu D, Zhang W, Jia H, Shi T, Gao W, Yin S, Feng Y, Xiang L, Okamoto A, Zang R

J Gynecol Oncol 31 ( 5 ) e86 2020.09

Research paper (scientific journal), Joint Work

Lymphadenectomy for primary ovarian cancer: a systematic review and meta-analysis

Chiyoda T, Sakurai M, Satoh T, Nagase S, Mikami M, Katabuchi H, Aoki D

J Gynecol Oncol 31 ( 5 ) e67 2020.09

Research paper (scientific journal), Joint Work

Impact of the COVID-19 epidemic at a high-volume facility in gynecological oncology in Tokyo, Japan: a single-center experience

Nogami Y, Kobayashi Y, Tsuji K, Yokota M, Nishio H, Nakamura M, Yamagami W, Morisada T, Tominaga E, Banno K, Aoki D

J Ovarian Res 13 ( 1 ) 105 2020.09

Research paper (scientific journal), Accepted

Erratum: Author Correction. Management of ovarian cancer patients in affected areas during COVID-19 pandemic: Japan and Korea

Kobayashi Y, Suh DH, Tsuji K, Kim JY, Shin S, Aoki D, Kim JW

J Gynecol Oncol 31 ( 5 ) e87 2020.09

Research paper (scientific journal), Joint Work

Cowden syndrome complicated by schizophrenia: A first clinical report

Kobayashi Y, Takeda T, Kunitomi H, Ueki A, Misu K, Kowashi A, Takahashi T, Anko M, Watanabe K, Masuda K, Uchida T, Tominaga E, Banno K, Kosaki K, Aoki D

Eur J Med Genet 63 ( 8 ) 103959 2020.08

Research paper (scientific journal), Joint Work

Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques

Kisu I, Emoto K, Masugi Y, Yamada Y, Matsubara K, Obara H, Matoba Y, Banno K, Kato Y, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Murase M, Nakagawa T, Tsuchiya H, Ishigaki H, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T

Sci Rep 10 ( 1 ) 13910 2020.08

Research paper (scientific journal), Joint Work

A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma

Yamagami W, Nagase S, Takahashi F, Ino K, Hachisuga T, Mikami M, Enomoto T, Katabuchi H, Aoki D

J Gynecol Oncol 31 ( 4 ) e45 2020.07

Research paper (scientific journal), Joint Work, Accepted

Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing

Nanki Y, Chiyoda T, Hirasawa A, Ookubo A, Itoh M, Ueno M, Akahane T, Kameyama K, Yamagami W, Kataoka F, Aoki D

Sci Rep 10 ( 1 ) 12581 2020.07

Research paper (scientific journal), Joint Work, Accepted

Hysteroscopic Photodynamic Diagnosis Using 5-Aminolevulinic Acid: A High-Sensitivity Diagnostic Method for Uterine Endometrial Malignant Diseases

Matoba Y, Banno K, Kisu I, Kobayashi Y, Tsuji K, Nagai S, Yamagami W, Nakamura M, Tominaga E, Kawaida M, Aoki D

J Minim Invasive Gynecol 27 ( 5 ) 1087 - 1094 2020.07

Research paper (scientific journal), Joint Work, Accepted

更年期症状を誘因に診断された甲状腺機能異常の2例

平田桃，横田めぐみ，谷本慧子，仲村勝，山上亘，森定徹，片岡史夫，岩田卓，阪埜浩司，田中守，青木大輔

東京産科婦人科学会会誌 69 ( 3 ) 575 - 580 2020.07

Research paper (scientific journal), Joint Work, Accepted

Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes

Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M

Jpn J Clin Oncol 50 ( 6 ) 643 - 652 2020.06

Research paper (scientific journal), Joint Work, Accepted

Prevalence of Disease-Causing Genes in Japanese Patients With BRCA1/2-wildtype Hereditary Breast and Ovarian Cancer Syndrome

Kaneyasu T, Mori S, Yamauchi H , Ohsumi S , Ohno S, Aoki D, Baba S, Kawano J, Miki Y, Matsumoto N, Nagasaki M, Yoshida R, Akashi-Tanaka S, Iwase T, Kitagawa D, Masuda K, Hirasawa A, Arai M, Takei J, Ide Y, Gotoh O, Yaguchi N, Nishi M, Kaneko K, Matsuyama Y, Okawa M, Suzuki M, Nezu A, Yokoyama S, Amino S, Inuzuka M, Noda T, Nakamura S

NPJ Breast Cancer 6 25 2020.06

Research paper (scientific journal), Joint Work, Accepted

Management of ovarian cancer patients in affected areas during COVID-19 pandemic: Japan and Korea

Kobayashi Y, Suh DH, Aoki D, Kim JW

J Gynecol Oncol 31 ( 3 ) e65 2020.05

Research paper (scientific journal), Joint Work

骨転移を伴う再発子宮体癌に対して、ホルモン療法とデノスマブの併用療法が効果を示した1例

佐竹恵，山上亘，吉村拓馬，平野卓朗，真壁健，坂井健良，辻浩介，小林佑介，片岡史夫，阪埜浩司，青木大輔，進伸幸

東京産科婦人科学会会誌 69 ( 2 ) 341 - 345 2020.04

Research paper (scientific journal), Joint Work, Accepted

頭痛および視野欠損を契機に診断に至った脳動脈解離による脳梗塞合併妊娠の1例

秋田啓介，春日義史，玉川真澄，上條慎太郎，大石真希，遠藤豊英，大谷利光，池ノ上学，落合大吾，宮越敬，田中守，青木大輔

東京産科婦人科学会会誌 69 ( 2 ) 212 - 217 2020.04

Research paper (scientific journal), Joint Work, Accepted

筋強直性ジストロフィー女性に対する着床前遺伝子診断による妊娠11例の後方視的検討

齋藤早貴，末岡浩，仙波宏史，佐藤卓，水口雄貴，樋口敦彦，田中守，青木大輔

東京産科婦人科学会会誌 69 ( 2 ) 153 - 158 2020.04

Research paper (scientific journal), Joint Work, Accepted

腹腔鏡下子宮筋腫核出術における超音波凝固切開装置と電気メス・クーパーの手術成績の比較検討

松沢優一，林茂徳，長谷川慶太，吉村拓馬，永井晋平，平野卓朗，千代田達幸，仲村勝，片岡史夫，田中守，青木大輔

東京産科婦人科学会会誌 69 ( 2 ) 147 - 152 2020.04

Research paper (scientific journal), Joint Work, Accepted

Pembrolizumab monotherapy in Japanese patients with advanced ovarian cancer: subgroup analysis from the KEYNOTE-100

Nishio S, Matsumoto K, Takehara K, Kawamura N, Hasegawa K, Takeshima N, Aoki D, Kamiura S, Arakawa A, Kondo E, Hirakawa T, Yamamoto K, Aoki M, Stein K, Keefe S, Fujiwara K, Ushijima K

(Cancer Sci) 111 ( 4 ) 1324 - 1332 2020.04

Research paper (scientific journal), Joint Work, Accepted

妊娠中期に卵巣癌と診断し、手術療法と化学療法治療後に生児を得られた1例

田中邦生，長谷川慶太，吉村拓馬，大石真希，大谷利光，池ノ上学，春日義史，落合大吾，岩田卓，宮越敬，田中守，青木大輔

東京産科婦人科学会会誌 69 ( 2 ) 387 - 391 2020.04

Research paper (scientific journal), Joint Work, Accepted

LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer

Kunitomi H, Kobayashi Y, Wu RC, Takeda T, Tominaga E, Banno K, Aoki D

J Gynecol Oncol 31 ( 2 ) e11 - e11 2020.03

Research paper (scientific journal), Joint Work, Accepted

The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics

Kunitomi H, Oki Y, Onishi N, Kano K, Banno K, Aoki D, Saya H, Nobusue H

25 ( 3 ) 165 - 174 2020.03

Research paper (scientific journal), Joint Work, Accepted

Significance of PD-L1 expression in carbon-ion radiotherapy for uterine cervical adeno/adenosquamous carcinoma

Iijima M, Okonogi N, Nakajima NI, Morokoshi Y, Kanda H, Yamada T, Kobayashi Y, Banno K, Wakatsuki M, Yamada S, Kamada T, Aoki D, Hasegawa S

J Gynecol Oncol 31 ( 2 ) e19 - e19 2020.03

Research paper (scientific journal), Joint Work, Accepted

市区町村事業として実施されている子宮頸がん検診にヒトパピローマウイルス（HPV）検査を導入した自治体におけるがん検診体制の実情

雑賀公美子，齊藤英子，河野可奈子，青木大輔，森定徹，高橋宏和，中山富雄，斎藤博

日本がん検診・診断学会誌 27 ( 2 ) 151 - 158 2020.01

Research paper (scientific journal), Joint Work, Accepted

Identification of a novel uterine leiomyoma GWAS locus in a Japanese population.

Sakai K, Tanikawa C, Hirasawa A, Chiyoda T, Yamagami W, Kataoka F, Susumu N, Terao C, Kamatani Y, Takahashi A, Momozawa Y, Hirata M, Kubo M, Fuse N, Takai-Igarashi T, Shimizu A, Fukushima A, Kadota A, Arisawa K, Ikezaki H, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Aoki D, Matsuda K

Scientific reports 10 ( 1 ) 1197 2020.01

Access to Document (DOI)

Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms

Yamagami W, Mikami M, Nagase S, Tabata T, Kobayashi Y, Kaneuchi M, Kobayashi H, Yamada H, Hasegawa K, Fujiwara H, Katabuchi H, Aoki D

J Gynecol Oncol 31 ( 1 ) e18 2020.01

Research paper (scientific journal), Joint Work, Accepted

Establishment and characterization of a new malignant peritoneal mesothelioma cell line, KOG-1, from the ascitic fluid of a patient with pemetrexed chemotherapy resistance

Akahane T, Hirasawa A, Imoto I, Okubo A, Itoh M, Nanki Y, Yoshihama T, Tominaga E, Aoki D

Hum Cell 33 ( 1 ) 272 - 282 2020.01

Research paper (scientific journal), Joint Work, Accepted

Primary malignant melanoma of the uterine cervix or vagina which were successfully treated with nivolumab

Anko M, Nakamura M, Kobayashi Y, Tsuji K, Nakada S, Nakamura Y, Funakoshi T, Banno K, Aoki D

J Obstet Gynaecol Res 46 ( 1 ) 190 - 195 2020.01

Research paper (scientific journal), Accepted

Spermatogenesis-associated changes of fucosylated glycolipids in murine testis

Iwamori M, Adachi S, Lin B, Tanaka K, Aoki D, Nomura T

Hum Cell 33 ( 1 ) 23 - 28 2020.01

Research paper (scientific journal), Joint Work, Accepted

Mutations of RAS genes in endometrial polyps

Takeda T, Banno K, Kobayashi Y, Adachi M, Yanokura M, Tominaga E, Kosaki K, Aoki D

Oncol Rep 42 ( 6 ) 2303 - 2308 2019.12

Research paper (scientific journal), Joint Work, Accepted

肥満が腹腔鏡下子宮体癌手術に及ぼす影響の検討

平野卓朗，片岡史夫，南木佳子，吉浜智子，真壁健，坂井健良，山上亘，林茂徳，野村弘行，青木大輔

日本産科婦人科内視鏡学会雑誌 35 ( 2 ) 238 - 243 2019.12

Research paper (scientific journal), Joint Work, Accepted

Erratum: Aurora kinase inhibitors: Potential molecular-targeted drugs for gynecologic malignant

Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D

Biomed Rep 11 ( 6 ) 274 - 274 2019.12

Research paper (scientific journal)

Analysis of the relapse patterns and risk factors of endometrial cancer following postoperative adjuvant chemotherapy in a phase III randomized clinical trial

Nomura H, Aoki D, Susumu N, Mizuno M, Nakai H, Arai M, Nishio S, Tokunaga H, Nakanishi T, Watanabe Y, Yaegashi N, Yokoyama Y, Takehara K

Gynecol Oncol 155 ( 3 ) 413 - 419 2019.12

Research paper (scientific journal), Joint Work, Accepted

Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?

Kobayashi Y, Banno K, Kunitomi H, Nagai S, Takahashi T, Anko M, Iijima M, Takeda T, Matoba Y, Nakamura K, Tsuji K, Tominaga E, Aoki D

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 28 ( 6 ) 562 - 567 2019.11

Research paper (scientific journal), Joint Work, Accepted, ISSN 0959-8278

Access to Document (DOI)

Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

Hirao N, Iwata T, Tanaka K, Nishio H, Nakamura M, Morisada T, Morii K, Maruyama N, Katoh Y, Yaguchi T, Ohta S, Kukimoto I, Aoki D, Kawakami Y

Gynecol Oncol 155 ( 2 ) 340 - 348 2019.11

Research paper (scientific journal), Joint Work, Accepted

Re: Rethinking the time interval to embryo transfer after uterus transplantation - DUETS (Dallas UtErus Transplant Study)

Kisu I, Banno K, Aoki D

BJOG 126 ( 12 ) 1508 - 1509 2019.11

Research paper (scientific journal), Joint Work

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O

Cancer Sci 110 ( 11 ) 3453 - 3463 2019.11

Research paper (scientific journal), Joint Work, Accepted

Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins

Takeda T, Komatsu M, Chiwaki F, Komatsuzaki R, Nakamura K, Tsuji K, Kobayashi Y, Tominaga E, Ono M, Banno K, Aoki D, Sasaki H

Cell Death Dis 10 ( 12 ) 876 2019.11

Research paper (scientific journal), Joint Work

Involvement of the MDR1 gene and glycolipids in anticancer drug-resistance of human ovarian carcinoma-derived cells.

Tanaka K, Kiguchi K, Mikami M, Aoki D, Iwamori M

Human cell 32 ( 4 ) 447 - 452 2019.10

ISSN 0914-7470

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Long-Term Outcome and Rejection After Allogeneic Uterus Transplantation in Cynomolgus Macaques

Kisu I, Ishigaki H, Emoto K, Kato Y, Yamada Y, Matsubara K, Obara H, Masugi Y, Matoba Y, Adachi M, Banno K, Saiki Y, Itagaki I, Kawamoto I, Iwatani C, Nakagawa T, Tsuchiya H, Sasamura T, Urano H, Ema M, Ogasawara K, Aoki D, Nakagawa K, Shiina T

J Clin Med 8 ( 10 ) 1572 2019.10

Research paper (scientific journal), Joint Work, Accepted

子宮悪性腫瘍手術直後の排尿障害に対する超音波断層法を用いた残尿量推定の有用性の検討：看護師による導尿前スクリーニングとして

飯島美穂，阪埜浩司，堀川未来，渡部景都，野上侑哉，青木大輔

日本婦人科腫瘍学会雑誌 37 ( 8 ) 714 - 722 2019.10

Research paper (scientific journal), Joint Work, Accepted

子宮鏡検査が子宮角部妊娠の診断に有用であった1例

岡愛実子，山田満稔，佐藤健二，升田博隆，上條慎太郎，浜谷敏生，田中守，青木大輔

東京産科婦人科学会会誌 68 ( 4 ) 710 - 713 2019.10

Research paper (scientific journal), Joint Work

A Clinical Trial to Verify the Efficiency of the LC-1000 Exfoliative Cell Analyzer as a New Method of Cervical Cancer Screening

Nakamura M., Ueda M., Iwata T., Kiguchi K., Mikami Y., Kakuma T., Aoki D.

Acta Cytologica 63 ( 5 ) 1 - 10 2019.09

Research paper (scientific journal), Accepted, ISSN 00015547

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Atypical polypoid adenomyoma treated by hysteroscopy with photodynamic diagnosis using 5-aminolevulinic acid: A case report

Matoba Y., Banno K., Kobayashi Y., Kisu I., Aoki D.

Photodiagnosis and Photodynamic Therapy (Photodiagnosis and Photodynamic Therapy) 27 295 - 297 2019.09

ISSN 15721000

© 2019 The Authors Surgical resection for atypical polypoid adenomyoma (APA) is an option for fertility preservation. Due to the high recurrence rate of APA, studies have been conducted to improve total resection of tumors. Photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) improves tumor resection, but this has not been applied for APA. The patient was 35-year-old. After initial treatment, the APA lesion did not disappear. We performed hysteroscopic tumor resection using 5-ALA-PDD. Only one PDD-positive lesion was found and histopathologically diagnosed as APA. Other areas were PDD-negative and showed no histopathologic APA or malignant findings. This is the first report of hysteroscopic 5-ALA-PDD for APA. This method makes it easy to identify morbid lesions, and may lead to improved total resection and decreased recurrence.

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Safety and efficacy of mucosal immunotherapy using human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine for the treatment of high-grade squamous intraepithelial lesion (HSIL): the study protocol of a randomized placebo-controlled clinical trial (MILACLE study)

Ikeda Y, Uemura Y, Asai-Sato M, Nakao T, Nakajima T, Iwata T, Akiyama A, Satoh T, Yahata H, Kato K, Maeda D, Aoki D, Kawana K

Jpn J Clin Oncol 49 ( 9 ) 877 - 880 2019.09

Research paper (scientific journal), Accepted

子宮体癌の術前子宮鏡検査と腹腔細胞診

平野卓朗，山上亘，真壁健，坂井健良，二宮委美，野村弘行，片岡史夫，平沢晃，進伸幸，青木大輔

日本臨床細胞学会雑誌 58 ( 5 ) 196 - 201 2019.09

Research paper (scientific journal), Joint Work, Accepted

Genome-wide DNA methylation profile of early-onset endometrial cancer: its correlation with genetic aberrations and comparison with late-onset endometrial cancer.

Makabe T, Arai E, Hirano T, Ito N, Fukamachi Y, Takahashi Y, Hirasawa A, Yamagami W, Susumu N, Aoki D, Kanai Y

Carcinogenesis 40 ( 5 ) 611 - 623 2019.07

ISSN 0143-3334

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The first Japanese nationwide multicenter study of <i>BRCA</i> mutation testing in ovarian cancer: CHARacterizing the cross-sectionaL approach to Ovarian cancer geneTic TEsting of <i>BRCA</i> (CHARLOTTE).

Enomoto T, Aoki D, Hattori K, Jinushi M, Kigawa J, Takeshima N, Tsuda H, Watanabe Y, Yoshihara K, Sugiyama T

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 29 ( 6 ) 1043 - 1049 2019.07

ISSN 1048-891X

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腫瘍の肉眼所見、画像所見と病理組織学所見との乖離から術前の原発巣確定に苦慮した2症例の経験

木村寛子，仲村勝，佐伯直彦，冨永英一郎，田中守，青木大輔

東京産科婦人科学会会誌 68 ( 3 ) 454 - 458 2019.07

Research paper (scientific journal), Joint Work, Accepted

Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid

Matoba Y., Banno K., Kisu I., Tsuji K., Aoki D.

Photodiagnosis and Photodynamic Therapy (Photodiagnosis and Photodynamic Therapy) 26 45 - 47 2019.06

ISSN 15721000

© 2019 The Authors Endometrial cancer is diagnosed by endometrial biopsy, imaging and hysteroscopy, but it is sometimes difficult to find small lesions. 5-aminolevulinic acid (5ALA) forms protoporphyrin IX, which accumulates in tumors and fluoresces upon light irradiation. 5ALA is used for photodynamic diagnosis (PDD) for detecting malignant diseases. A 60-year-old female was suspected to have endometrial cancer by magnetic resonance imaging. Endometrial biopsy was performed repeatedly, but no malignant lesion was detected. We performed hysteroscopic 5ALA-PDD and could detect a small lesion. The lesion was excised and diagnosed as atypical endometrial hyperplasia histopathologically. This is the first report that showed hysteroscopic 5ALA-PDD can contribute to diagnosis of early-stage neoplastic lesion in the uterine cavity.

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Effect of Taxane Plus Platinum Regimens vs Doxorubicin Plus Cisplatin as Adjuvant Chemotherapy for Endometrial Cancer at a High Risk of Progression: A Randomized Clinical Trial

Nomura H., Aoki D., Michimae H., Mizuno M., Nakai H., Arai M., Sasagawa M., Ushijima K., Sugiyama T., Saito M., Tokunaga H., Matoda M., Nakanishi T., Watanabe Y., Takahashi F., Saito T., Yaegashi N.

JAMA Oncology (JAMA Oncology) 5 ( 6 ) 833 - 840 2019.06

ISSN 23742437

© 2019 American Medical Association. All rights reserved. Importance: The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it has not been assessed in postoperative adjuvant chemotherapy for endometrial cancer. Objective: To evaluate the clinical benefit of taxane plus platinum compared with standard doxorubicin plus cisplatin as postoperative adjuvant chemotherapy in endometrial cancer. Design, Setting, and Participants: In this multicenter, open-label, phase 3 randomized clinical trial, patients with endometrial cancer at high-risk stage I or II or stage III or IV that did not extend beyond the abdominal cavity and had 2 cm or greater residual tumor were included from 118 institutions in Japan from November 24, 2006, to January 7, 2011. Data was analyzed from March 15, 2017, to June 30, 2017. Interventions: Eligible patients were randomly assigned (1:1:1) to receive 6 cycles of doxorubicin, 60 mg/m2, plus cisplatin, 50 mg/m2, on day 1; docetaxel, 70 mg/m2, plus cisplatin, 60 mg/m2, on day 1; or paclitaxel, 180 mg/m2, plus carboplatin (area under the curve, 6.0 mg/mL × min) on day 1 every 3 weeks. Main Outcomes and Measures: The primary end point was progression-free survival. Secondary end points were overall survival, occurrence of adverse events, tolerability, and status of lymph node dissection. Results: Among 788 eligible patients, the median (SD) age was 59 (22-74) years; 263 patients were assigned to doxorubicin plus cisplatin treatment, 263 patients to docetaxel plus cisplatin treatment, and 262 patients to paclitaxel plus carboplatin treatment. The number of patients who did not complete 6 cycles was 53 (20.1%) for the doxorubicin plus cisplatin group, 45 (17.1%) for the docetaxel plus cisplatin group, and 63 (24.0%) for the paclitaxel plus carboplatin group. Tolerability of these regimens were not statistically different. After a median follow-up period of 7 years, there was no statistical difference of progression-free survival (doxorubicin plus cisplatin, 191; docetaxel plus cisplatin, 208; paclitaxel plus carboplatin, 187; P =.12) or overall survival (doxorubicin plus cisplatin, 217; docetaxel plus cisplatin, 223; paclitaxel plus carboplatin, 215; P =.67) among the 3 groups. The 5-year progression-free survival rate was 73.3% for the doxorubicin plus cisplatin group, 79.0% for the docetaxel plus cisplatin group, and 73.9% for the paclitaxel plus carboplatin group, while the 5-year overall survival rates were 82.7%, 88.1%, and 86.1%, respectively. Conclusions and Relevance: There was no significant difference of survival among patients receiving doxorubicin plus cisplatin, docetaxel plus cisplatin, or paclitaxel plus carboplatin as postoperative adjuvant chemotherapy for endometrial cancer. Because each regimen showed adequate tolerability but different toxic effects, taxane plus platinum regimens may be a reasonable alternative to treatment with doxorubicin plus cisplatin. Trial Registration: UMIN-CTR identifier: UMIN000000522.

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Characterization of a novel glycolipid with a difucosylated H-antigen in human blood group O erythrocytes with monoclonal antibody HMMC-1 and its detection in human uterine cervical carcinoma tissues.

Tanaka K, Suzuki A, Aoki D, Iwamori M

Glycoconjugate journal 36 ( 3 ) 219 - 226 2019.06

ISSN 0282-0080

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Uterus transplantation: advantages and disadvantages of a deceased donor

Kisu I, Banno K, Matoba Y, Aoki D

Arch Gynecol Obstet 299 ( 5 ) 1213 - 1214 2019.05

Research paper (scientific journal)

Local anatomy around terminal ureter related to the anterior leaf of the vesicouterine ligament in radical hysterectomy

Nakamura M, Tanaka K, Hayashi S, Morisada T, Iwata T, Imanishi N, Aoki D

Eur J Obstet Gynecol Reprod Biol (European Journal of Obstetrics and Gynecology and Reproductive Biology) 235 66 - 70 2019.04

Research paper (scientific journal), Accepted, ISSN 03012115

© 2019 Elsevier B.V. Objectives: Radical hysterectomy is performed for invasive cervical cancer. In this surgery, separation of the anterior leaf and posterior leaves of the vesicouterine ligament (VUL) is important. We studied the local anatomy of the anterior leaf of the VUL, especially the branches of the umbilical artery from the view point of surgery and cadaver dissection. Study Design: We observed the cervicovesical blood vessels and the connective tissue layer continued from umbilical artery and searched for the origin of the cervicovesical blood vessels in radical hysterectomy. We also dissected a formalin-fixed female cadaver, and observed the same points. Results: After separation of the connective tissue of urinary bladder from the cervical fascia, we could discern the outline of the distal ureter near the ureterovesical junction. We separate the connective tissue of the so-called anterior leaf of the VUL enwrapping the ureter gently, and then the ureter with the connective tissue is completely rolled out laterally. We identified a cervicovesical vessel crossing over the ureter. We looked for the central side of the cervicovesical vessel and found that cervicovesical vessel was a branch of the superior vesical artery. And, during cadaver dissection, we found that the connective tissue and the branches of the superior vesical artery were similarly observed. Conclusions: We found the precise anatomy of the connective tissue layer from umbilical artery to urinary bladder and the superior vesical artery. Our procedure based on the precise anatomy obtained in this study is reasonable anatomically as a method for separation of the vesicouterine ligament during radical hysterectomy.

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分娩後に急性腎不全を発症し非典型溶血性尿毒症症候群(aHUS)と診断した1例

竹田将人, 池ノ上学, 坂井健良, 遠藤豊英, 大石真希, 落合大吾, 宮越敬, 田中守, 青木大輔

東京産科婦人科学会会誌 ((一社)東京産科婦人科学会) 68 ( 2 ) 339 - 343 2019.04

Research paper (scientific journal), Accepted, ISSN 2186-0599

血栓性微小血管症(TMA)は溶血性貧血、血小板減少、臓器機能障害を三徴とする病態であり、非典型溶血性尿毒症症候群(atypical hemolytic uremic syndrome:aHUS)はその一つである。今回、分娩後経過から早期にaHUSを診断し、良好な予後を得た症例を経験したため報告する。症例は33歳、1妊1産。妊娠経過は良好で、妊娠38週に自然経腟分娩となった。分娩後、弛緩出血に対して輸血および子宮内バルーンタンポナーデを行い止血を得たが、産後2日目より腎機能障害、肝機能障害を認め当院へ搬送となった。TMAの三徴を認め、ADAMTS-13活性は正常値でありaHUSと診断した。血液透析と血漿補充により腎機能は改善し、産後22日目に退院となった。溶血性貧血と血小板減少を伴う急激な腎機能障害を認めた場合、早期からaHUSを鑑別疾患に挙げることが肝要である。(著者抄録)

Laparoscopic Surgery for Ovarian Cyst Infection with Avoidance of Ureteral Injury and Uterine Perforation following Intrauterine Insemination after Abdominal Modified Radical Trachelectomy.

Iijima M, Hayashi S, Kobayashi Y, Tsuji K, Tominaga E, Banno K, Aoki D

Case Rep Obstet Gynecol 2019 8607417 2019.04

Research paper (scientific journal), ISSN 2090-6684

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Warburg effect in Gynecologic cancers

Kobayashi Y, Banno K, Kunitomi H, Takahashi T, Takeda T, Nakamura K, Tsuji K, Tominaga E, Aoki D

Journal of Obstetrics and Gynaecology Research (J Obstet Gynaecol Res) 45 ( 3 ) 542 - 548 2019.03

Research paper (scientific journal), ISSN 13418076

© 2018 Japan Society of Obstetrics and Gynecology Mammalian cells produce energy by oxidative phosphorylation under aerobic conditions. However, in the 1920s, Otto Warburg reported the so-called “Warburg effect” in which cancer cells produce ATP that is biased toward glycolysis rather than mitochondrial oxidative phosphorylation not only in anaerobic environment but also in aerobic environment. Glucose is converted into lactate without going into mitochondria after being metabolized in glycolysis. Compared with oxidative phosphorylation, the glycolysis has a faster ATP production rate but it is very inefficient, resulting in cancer cells consuming a large amount of glucose. Increased glucose metabolism has become a biomarker for cancer cells and has led to the development of positron emission tomography with fluorodeoxyglucose. Till date, the Warburg effect has been an inefficient system for cancer cells with regard to efficient energy production, but since the consumption of oxygen can be suppressed as the tumor grows in mass, it is thought that the Warburg effect is advantageous in this situation wherein the tumor can increase despite the lack of vessels. In addition, an increased lactate by the glycolysis causes acidosis in the microenvironment of tissues, which is thought to damage the surrounding normal tissues and favor the invasion and metastasis of cancer. Thus, Warburg effect is one of the key mechanisms for cancer development and will be the next promising target. In this review, we introduce key players that can be targeted in the Warburg effect and outline the prospects of treatment, targeting the Warburg effect in gynecological cancer.

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腹腔内へ迷入した異物(ミレーナ)を腹腔鏡下手術により回収し得た1例

中村加奈子, 林茂徳, 安康真由香, 清河駿樹, 水口雄貴, 冨永英一郎, 阪埜浩司, 青木大輔

栃木県産婦人科医報 (栃木県産科婦人科学会) 45 25 - 29 2019.03

子宮内避妊器具や子宮内黄体ホルモン放出システム(ミレーナ)は避妊や月経困難症の治療のために使用されるが子宮穿孔や腹腔内への迷入などの合併症を来たすことがある。今回我々は、腹腔内に迷入したミレーナを腹腔鏡下手術により回収した症例を経験した。術中、ミレーナは鏡視下の観察のみで容易に発見できたが大網に強固に癒着していたため、大網とともに部分切除することで合併症を来たすことなく回収した。腹腔内異物を腹腔鏡下手術により摘出を試みる場合、異物の発見が鏡視下の観察のみで困難な場合を想定した外科用X線撮影装置の準備や強固な癒着を想定した術式を計画することが安全に手術による摘出を成功させる上で重要である。(著者抄録)

子宮頸がん検診の現状と課題

青木大輔

東京都医師会雑誌 72 ( 3 ) 9 - 12 2019.03

Research paper (scientific journal)

がん検診における精度管理の考え方－アセスメントとマネジメントの関係性を踏まえて－

青木大輔，森定徹

日本産科婦人科学会雑誌 71 ( 3 ) 449 - 458 2019.03

Research paper (scientific journal), Joint Work

婦人科がん術後の残尿量測定において看護師による超音波断層法を受けた患者の主観的な評価 ―アンケート調査より―

宗知美，高根沢美輝，粟津未紀，三浦美紀，田邊愛，齋藤理恵，飯島美穂，渡部景都，堀川未来，片岡美樹，菊地敦子，野上侑哉，阪埜浩司，青木大輔

日本看護学会論文集　急性期看護 49 194 - 197 2019.03

Research paper (scientific journal), Joint Work

Current status of uterine regenerative medicine for absolute uterine factor infertility

Matoba Y, Kisu I, Sera A, Yanokura M, Banno K, Aoki D

Biomed Rep 10 ( 2 ) 79 - 86 2019.02

Research paper (scientific journal), Joint Work

Gynecologic Cancer by Pyrosequencing the 16S Ribosomal RNA Gene Using Next-Generation Sequencing Technology

Nogami Y, Banno K, Adachi M, Kunitomi H, Kobayashi Y, Tominaga E, Aoki D

Infect Dis Obstet Gynecol 2019 9326285 2019.02

Research paper (scientific journal), Accepted

Current status of uterine regenerative medicine for absolute uterine factor infertility (Review)

Matoba Y., Kisu I., Sera A., Yanokura M., Banno K., Aoki D.

Biomed Rep 10 ( 2 ) 79 - 86 2019.02

Research paper (scientific journal), ISSN 20499434

© 2019, Spandidos Publications. All rights reserved. Though assisted reproduction technology has been developed, a treatment for absolute uterine factor infertility (AUFI), such as defects in the uterus, has not yet been established. Regenerative medicine has been developed and applied clinically over recent years; however, whole solid organs still cannot be produced. Though uterine regeneration has the potential to be a treatment for AUFI, there have been only a few studies on uterine regeneration involving the myome-trium in vivo. In the present report, those relevant articles are reviewed. A literature search was conducted in PubMed with a combination of key words, and 10 articles were found, including nine in rat models and one in a mouse model. Of these studies, eight used scaffolds and two were performed without scaffolds. In four of these studies, scaffolds were re-cellularized with various cells. In the remaining four studies, scaffolds were transplanted alone, or other structures were used. Though the methods differed, the injured uterus recovered well, morphologically and functionally, in every study. Only 10 articles were relevant to our investigation, but the results were favorable, if limited to partial regeneration. Recently, uterus transplantation (UTx) has been investigated as a treatment for AUFI. However, UTx has many problems in the medical, ethical and social fields. Though the artificial uterus was also researched and some improvements in this technology were reported, it will take long time for this to reach a clinically applicable stage. Though the results of uterine regeneration studies were promising, these studies were conducted using animal models, so further human studies and trials are needed.

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Profiling of the Causative Bacteria in Infected Lymphocysts after Lymphadenectomy for Gynecologic Cancer by Pyrosequencing the 16S Ribosomal RNA Gene Using Next-Generation Sequencing Technology

Nogami Y., Banno K., Adachi M., Kunitomi H., Kobayashi Y., Tominaga E., Aoki D.

Infect Dis Obstet Gynecol 2019 9326285 2019.02

Research paper (scientific journal), ISSN 10647449

© 2019 Yuya Nogami et al. Background. Surgery for gynecologic cancer with lymphadenectomy and pelvic radiotherapy can produce lymphoceles that sometimes complicate with infection, resulting in abscesses. The true pathogenic bacteria of abscesses are not always found because of false-negative results due to administered antibiotics and difficulty with detection, including for anaerobic bacteria. Analyzing bacteria flora by next-generation sequencing (NGS) using 16S ribosomal DNA may reveal the true pathogenic bacteria in abscesses. This is the first report on causative pathogens for infectious lymphocele using this technology. Methods. The subjects were patients who developed infectious lymphocele after surgery for gynecologic cancer at our hospital from July 2015 to September 2016. NGS analyses of bacterial flora were performed using specimens preserved at -80°C. Two steps of PCR were performed for purified DNA samples to obtain sequence libraries. Processing of sequence data, including operational taxonomic unit (OTU) definition, taxonomy assignment, and an OTU BLAST search were performed. All patients gave written informed consent and the study was approved by the institutional research ethics committee. Results. Six patients underwent puncture and drainage. The result in most cases indicated a single causative pathogen, including Staphylococcus lugdunensis, Streptococcus dysgalactiae, Streptococcus equinus, Enterococcus saccharolyticus, and Escherichia coli. Conclusions. NGS revealed that the causative bacteria in lymphocele infection are normally a single strain, such as a surface Gram-positive coccus or enteric bacteria. Antibiotics should be chosen as appropriate for elimination of these respective bacteria.

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Current Progress in Uterus Transplantation Research in Asia

Kisu I, Liu Y, Chen G, Song MJ, Chang CY, Koon TH, Banno K, Aoki D

J Clin Med 8 ( 2 ) E245 2019.02

Research paper (scientific journal)

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子宮頸がん検診へのHPV検査導入までの経緯とその運用－オランダ・オーストラリアの事例－

AOKI DAISUKE

日本がん検診・診断学会誌 26 ( 2 ) 139 - 146 2019.01

Research paper (scientific journal), Joint Work

Current state and outlook for drug repositioning anticipated in the field of ovarian cancer

Kobayashi, Y., Banno, K., Kunitomi, H., Tominaga, E. and Aoki, D.

J Gynecol Oncol (Journal of Gynecologic Oncology) 30 ( 1 ) e10 2019.01

Research paper (scientific journal), Joint Work, ISSN 2005-0380

Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the prognosis remains poor, and it is highly anticipated that new drugs will be developed. New drugs, such as humanized anti-vascular endothelial growth factor monoclonal antibodies and poly ADP-ribose polymerase inhibitors, are expected to improve clinical outcomes of ovarian cancer. However, long-term, costly research is required to develop such new drugs, and soaring national healthcare costs are becoming a concern worldwide. In this social context, drug repositioning, wherein existing drugs are used to develop drugs with new indications for other diseases, has recently gained attention. Because trials have already confirmed the safety in humans and the pharmacokinetics of such drugs, the development period is shorter than the conventional development of a new drug, thereby reducing costs. This review discusses the available basic experimental and clinical data on drugs used for other types of cancer for which drug repositioning is anticipated to repurpose the drug for the treatment of ovarian cancer. These include statins, which are used to treat dyslipidemia; bisphosphonate, which is used to treat osteoporosis; metformin, which is used to treat diabetes; non-steroidal anti-inflammatory drugs; ivermectin, an antiparasitic agent; and itraconazole, an anti-fungal agent. These drugs will play an important role in future drug repositioning strategies for ovarian cancer. Furthermore, drug repositioning is anticipated to extend not only to ovarian cancer treatment but also to ovarian cancer prevention.

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Japan Societyof Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer

Ebina Y, Mikami M, Nagase S, Tabata T, Kaneuchi M, Tashiro H, Mandai M, Enomoto T, Kobayashi Y, Katabuchi H, Yaegashi N, Udagawa Y, Aoki D

Int J Clin Oncol (International Journal of Clinical Oncology) 24 ( 1 ) 1 - 19 2019.01

Research paper (scientific journal), Joint Work, ISSN 13419625

© 2018, Japan Society of Clinical Oncology. The Japan Society of Gynecologic Oncology (JSGO) Guidelines 2017 for the Treatment of Uterine Cervical Cancer are for the purpose of providing standard treatment strategies for cervical cancer, indicating treatment methods currently considered appropriate for cervical cancer, minimizing variances in treatment methods among institutions, improving the safety of treatment and prognosis of diseases, reducing the economic and psychosomatic burden of patients by promoting performance of appropriate treatment, and enhancing mutual understanding between patients and healthcare professionals. The guidelines were prepared through consensus of the JSGO Guideline Committee, based on careful review of evidence gathered through the literature searches and in view of the medical health insurance system and actual clinical practice situations in Japan. The guidelines comprise eight chapters and five algorithms. The main features of the 2017 revision are as follows: (1) evidence was collected using a search formula and with cooperation of the Japan Library Association. The bibliographical search formula was placed at the end of the book; (2) regarding clinical questions (CQs) where evidence or clinical inspection in Japan was lacking, opinions of the Guidelines Committee were described as “proposals for future directions”; (3) cervical intraepithelial neoplasia (CIN) 3 and adenocarcinoma in situ (AIS) were treated as a cervical precancerous lesion; (4) the CQs of endoscopic surgery, radical trachelectomy, and sentinel node biopsy were newly added in Chapter 3, “primary treatment for stage IB–II cervical cancer”; and (5) the CQ about hormone replacement therapy after cancer treatment was newly established. Each recommendation is accompanied by a classification of recommendation categories based on the consensus reached by the Guideline Committee members. Here, we present the English version of the JSGO Guidelines 2017 for the Treatment of Uterine Cervical Cancer.

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特発性血小板減少性紫斑病（ITP）を合併した抗リン脂質抗体症候群（APS）に対し脾臓摘出および抗血栓療法にて生児を得た1例

AOKI DAISUKE

東京産科婦人科学会会誌 68 ( 1 ) 48 - 52 2019.01

Research paper (scientific journal), Joint Work

当院における静脈内平滑筋腫症（IVL）3症例の治療経験

AOKI DAISUKE

東京産科婦人科学会会誌 68 ( 1 ) 107 - 114 2019.01

Research paper (scientific journal), Joint Work

術中に回収したフィルム破片が術後にトロッカーのソフトバルブであると判明した1例

小林佑介，野村弘行，仲村勝，山上亘，林茂徳，森定徹，片岡史夫，冨永英一郎，阪埜浩司，青木大輔

東京産科婦人科学会会誌 68 ( 1 ) 69 - 72 2019.01

Research paper (scientific journal), Joint Work

若年子宮体癌/子宮内膜異型増殖症に対する高用量黄体ホルモン療法の再発例の検討

北澤晶子，山上亘，真壁健，平野卓朗，坂井健良，千代田達幸，小林佑介，野村弘行，片岡史夫，阪埜浩司，進伸幸，田中守，青木大輔

関東連合産科婦人科学会誌 56 ( 4 ) 591 - 596 2019

Research paper (scientific journal), Joint Work

Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: a review

Matoba, Y., Banno, K., Kisu, I. and Aoki, D.

Photodiagnosis Photodyn Ther 24 52 - 57 2018.12

Joint Work, ISSN 1572-1000

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子宮頸がん検診の精度管理の考え方

青木大輔

広島県臨床細胞学会誌 39 1 - 8 2018.12

Research paper (scientific journal)

難治性骨盤内炎症性疾患を呈した好酸球性胃腸炎の1例

AOKI DAISUKE

関東連合産科婦人科学会誌 55 ( 4 ) 453 - 458 2018.11

Joint Work

Current Status of Uterus Transplantation and Approaches for Future Clinical Application in Japan

Kisu, I., Banno, K., Matoba, Y., Adachi, M. and Aoki, D.

Transplant Proc 50 ( 9 ) 2783 - 2788 2018.11

ISSN 0041-1345

Uterus transplantation (UTx) has become an alternative to gestational surrogacy and adoption for women with uterine factor infertility (UFI). Brannstrom et al achieved the first human delivery after UTx in 2014, and to date a total of 8 babies have been born after UTx from living donors. This outcome has attracted much attention worldwide, and many countries are now preparing for UTx. There are an estimated 60,000 women of reproductive age with UFI in Japan, and these patients cannot have biological children because gestational surrogacy is forbidden in Japan. We have performed UTx research from 2009 using cynomolgus macaque, in preparation for clinical application of UTx for these patients to have a child, and we have accumulated a large amount of data. However, the UTx procedure still has many medical, ethical, and social issues that require discussion prior to clinical application. The Japan Society for Uterus Transplantation was established in 2014 for further discussion of these issues in Japan. UTx is still in the experimental stage overseas, and the safety and efficacy remain unclear, despite several clinical applications. Despite the many issues to be resolved, this organ transplantation technology will provide new hope for women with UFI, and further development of the technology is important for future reproductive and transplant medicine. In this article, we summarize the current status of UTx and the situation regarding future clinical application in Japan.

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Synchronous endometrial and ovarian cancer in Lynch syndrome with a MSH2 germline mutation: A case report

Takeda, T., Banno, K., Yanokura, M., Anko, M., Kobayashi, A., Sera, A., Takahashi, T., Adachi, M., Kobayashi, Y., Hayashi, S., Nomura, H., Hirasawa, A., Tominaga, E. and Aoki, D.

Mol Clin Oncol 9 ( 5 ) 479 - 484 2018.11

ISSN 2049-9450

Synchronous endometrial and ovarian cancer (SEOC) is a rare entity among gynecological cancers, which exhibits endometrioid histology in its early stages and generally has a good prognosis. However, diagnosis is difficult and recent reports have demonstrated that most clinically diagnosed cases of SEOC have clonally related cancers, indicating metastatic cancer. The association of SEOC with Lynch syndrome is also not clearly understood. We herein present the case of a 41-year-old SEOC patient with MSH2 mutation. The endometrial cancer was an endometrioid adenocarcinoma and the ovarian cancer was mainly endometrioid, but also included a clear cell carcinoma with a borderline clear cell adenofibromatous component, indicating primary ovarian cancer. Both tumors exhibited microsatellite instability (MSI) and loss of expression of MSH2 and MSH6. The patient had a family history of colorectal and gastric cancers. Genetic analysis revealed a germline mutation in exon 6 of MSH2 (c.1042C>T, p.Gln348*) and the patient was diagnosed with Lynch syndrome. This MSH2 mutation has only been registered in one case in the InSiGHT variant databases and has not been reported in a gynecological tumor or SEOC to date. This case is a rare example of a patient with genetically diagnosed Lynch syndrome who also developed SEOC. This synchronous cancer is not common, but it may be caused by Lynch syndrome. Testing for MSI and immunohistochemistry for mismatch repair deficiency is necessary in cases with suspected SEOC.

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女性性器形成手術を振り返って得られた鏡視下手術併用の有用性についての検討

AOKI DAISUKE

関東連合産科婦人科学会誌 55 ( 4 ) 573 - 578 2018.11

Research paper (scientific journal), Joint Work

新生児皮膚所見および家族歴から色素失調症と診断された不育症の一例

AOKI DAISUKE

関東連合産科婦人科学会誌 55 ( 4 ) 529 - 533 2018.11

Joint Work

遺伝性乳癌卵巣癌に対するリスク低減卵管卵巣摘出後のQOLに関する検討

谷本慧子，平沢晃，牧田和也，岩田卓，堀場裕子，横田めぐみ，小川真里子，弟子丸亮太，柳本茂久，高松潔，青木大輔

日本女性医学学会雑誌 26 ( 1 ) 45 - 47 2018.11

Research paper (scientific journal), Joint Work

Emerging problems in uterus transplantation

Kisu, I., Kato, Y., Obara, H., Matsubara, K., Matoba, Y., Banno, K. and Aoki, D.

Bjog 125 ( 11 ) 1352 - 1356 2018.10

Research paper (scientific journal), ISSN 1470-0328

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Basic research on uterus transplantation in nonhuman primates in Japan

Kisu, I., Banno, K., Matoba, Y., Adachi, M. and Aoki, D.

J Obstet Gynaecol Res 44 ( 10 ) 1871 - 1881 2018.10

ISSN 1341-8076

Uterus transplantation (UTx) is now a potential option for women with uterine factor infertility to have a child. However, UTx is still in an experimental stage and basic animal studies including in nonhuman primates are needed for accumulation of data that will provide important information for establishment of UTx in humans. Herein, we summarized our experiences using cynomolgus macaques, with the goal of promoting further development of UTx studies in nonhuman primates. Our basic studies using cynomolgus macaques were summarized, including the results of other teams in nonhuman primates. Our team in Japan launched UTx research in 2009 using cynomolgus macaques and has accumulated a large archive of results in the UTx research field, including examination of uterine blood flow, surgical procedures of autologous and allogeneic UTx, organ perfusion methods in deceased donor models, immunological response and rejection and ischemia/reperfusion injury. We achieved the first delivery after autologous UTx in primates and the first periodic recovery of menstruation after allogeneic UTx in nonhuman primate models. Results from animal studies, including those in nonhuman primates, provide the basis for clinical application of UTx. Therefore, our accumulated data since 2009 and our basic experience in cynomolgus macaque are meaningful for future UTx trials in Japan. In addition, more validation in nonhuman primate models is needed for resolution of medical issues and further development of UTx in humans, despite clinical application of UTx in several countries.

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Phase III study of cisplatin with or without S-1 in patients with stage IVB, recurrent, or persistent cervical cancer

Aoki, Y., Ochiai, K., Lim, S., Aoki, D., Kamiura, S., Lin, H., Katsumata, N., Cha, S. D., Kim, J. H., Kim, B. G., Hirashima, Y., Fujiwara, K., Kim, Y. T., Kim, S. M., Chung, H. H., Chang, T. C., Kamura, T., Takizawa, K., Takeuchi, M. and Kang, S. B.

Br J Cancer 119 ( 5 ) 530 - 537 2018.08

ISSN 0007-0920

BACKGROUND: This open-label phase III trial evaluated efficacy and safety of S-1 plus cisplatin vs. cisplatin alone as first-line chemotherapy in patients with stage IVB, recurrent, or persistent cervical cancer. METHODS: Patients were randomised (1:1) to S-1 plus cisplatin (study group) or cisplatin alone (control group). In each cycle, cisplatin 50 mg/m(2) was administered on Day 1 in both groups. S-1 was administered orally at 80-120 mg daily on Days 1-14 of a 21-day cycle in the study group. The primary endpoint was overall survival (OS). RESULTS: A total of 375 patients were enrolled, of whom 364 (188, study group; 176, control group) received treatment. Median OS was 21.9 and 19.5 months in the study and control groups, respectively (log-rank P = 0.125; hazard ratio [HR] 0.84, 95% confidence interval [CI] 0.67-1.05). Median progression-free survival (PFS) was 7.3 and 4.9 months in the study and control groups, respectively (HR 0.62, 95% CI 0.48-0.80, P < 0.001). The adverse event (AE) rate increased in the study group despite the absence of any unexpected AEs. CONCLUSIONS: S-1 plus cisplatin did not show superiority over cisplatin alone in OS but significantly increased PFS in patients with stage IVB, recurrent, or persistent cervical cancer. Since the standard therapy has changed in the course of this study, further studies are warranted to confirm the clinical positioning of S-1 combined with cisplatin for this population.

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GSTP1 rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes

Yoshihama, T., Fukunaga, K., Hirasawa, A., Nomura, H., Akahane, T., Kataoka, F., Yamagami, W., Aoki, D. and Mushiroda, T.

Oncotarget 9 ( 51 ) 29789 - 29800 2018.07

Research paper (scientific journal), Joint Work, ISSN 1949-2553

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腫瘍内出血により重症貧血をきたし、早期新生児死亡に至った胎児リンパ管腫の1例

AOKI DAISUKE

東京産科婦人科学会会誌 67 ( 3 ) 463 - 466 2018.07

Research paper (scientific journal), Joint Work

有害事象によりベバシズマブ投与を中止した婦人科がん症例の検討

AOKI DAISUKE

東京産科婦人科学会会誌 67 ( 3 ) 396 - 400 2018.07

Joint Work

Clinical management of epithelial ovarian cancer

Kobayashi Y., Nomura H., Kataoka F., Tominaga E., Banno K., Aoki D.

Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects (Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects) 135 - 151 2018.06

© Springer Nature Singapore Pte Ltd 2018. Ovarian cancer has high morbidity and mortality worldwide, and its mortality is the highest among female genital cancers. Improvement in clinical outcome is an urgent issue for ovarian cancer, and clinical management including treatment has been repeatedly studied. Tumor markers such as CA125, CA19-9, and HE4 and image diagnosis using MRI, CT, PET, etc. are indispensable diagnostic aid tools. In the initial treatment, primary debulking surgery (PDS) is basically effective, but fertility preservation can be considered depending on the case. For advanced cancers, interval debulking surgery (IDS) is considered after several cycles of neoadjuvant chemotherapy (NAC). Although the combination of paclitaxel and carboplatin (TC) regimen was originally established as the standard chemotherapy for ovarian cancer regardless of tissue type, new treatments in clinical trials, including molecular-targeted therapeutic agents, are being investigated. The main treatment for recurrent cancer is chemotherapy, and sensitivity to chemotherapy based on the disease-free interval has been considered in the choice of treatment. Furthermore, in recent years, risk-reducing bilateral salpingo-oophorectomy has been undertaken to prevent the onset of hereditary breast and ovarian cancer. It is also being studied how to manage the follow-up after treatment and hormone replacement.

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Liquid-based cytology versus conventional cytology for detection of uterine cervical lesions: a prospective observational study

Nishio, H., Iwata, T., Nomura, H., Morisada, T., Takeshima, N., Takano, H., Sasaki, H., Nakatani, E., Teramukai, S. and Aoki, D.

Jpn J Clin Oncol 48 ( 6 ) 522 - 528 2018.06

ISSN 0368-2811

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Postoperative chemotherapy for node-positive cervical cancer: Results of a multicenter phase II trial (JGOG1067)

Matoda, M., Takeshima, N., Michimae, H., Iwata, T., Yokota, H., Torii, Y., Yamamoto, Y., Takehara, K., Nishio, S., Takano, H., Mizuno, M., Takahashi, Y., Takei, Y., Hasegawa, T., Mikami, M., Enomoto, T., Aoki, D. and Sugiyama, T.

Gynecol Oncol 149 ( 3 ) 513 - 519 2018.06

ISSN 0090-8258

OBJECTIVE: This multicenter phase II Japanese Gynecologic Oncology Group study (JGOG1067) was designed to evaluate the efficacy and safety of postoperative chemotherapy in patients with node-positive cervical cancer. METHODS: Patients with stage IB-IIA squamous cervical cancer who underwent radical hysterectomy and were confirmed to have pelvic lymph node metastasis were eligible for this study. The patients postoperatively received irinotecan (CPT-11; 60mg/m(2) intravenously on days 1 and 8) and nedaplatin (NDP; 80mg/m(2) intravenously on day 1). Chemotherapy administration commenced within 6weeks after surgery and was repeated every 28days for up to 5cycles. The primary endpoint of this study was the 2-year recurrence-free survival (RFS) rate. The secondary endpoints were the 5-year overall survival (OS) rate, 5-year RFS rate, and adverse events such as complications of chemotherapy and lower-limb edema. RESULTS: Sixty-two patients were analyzed according to our protocol, among whom 55 (88.7%) completed 5cycles of scheduled treatment. The median follow-up period was 66.1months (range, 16.8-96.6months). The 2-year and 5-year RFS rates were 87.1% (95% confidence interval [CI]: 75.9-99.3) and 77.2% (95% CI: 64.5-85.8), respectively. Fourteen patients (22.5%) experienced recurrence during the follow-up period, 8 of whom died of the disease. The 5-year OS rate in this study was 86.5% (95% CI: 74.8-93.0). Only 9.7% of the patients experienced lymphedema in their legs. CONCLUSION: Postoperative chemotherapy without radiotherapy was found to be very effective in high-risk patients with node-positive cervical cancer.

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Population-based cohort study assessing the efficacy of cervical cytology (Pap smear) and human papillomavirus (HPV) testing as modalities for cervical cancer screening

Morisada, T., Saika, K., Saito, E., Kono, K., Saito, H. and Aoki, D.

Jpn J Clin Oncol 48 ( 5 ) 495 - 498 2018.05

ISSN 0368-2811

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Isolation techniqueを用いた腹腔鏡下卵巣腫瘍摘出における回収袋の工夫

AOKI DAISUKE

東京産科婦人科学会会誌 67 ( 2 ) 341 - 348 2018.05

Joint Work

Multicenter Clinicopathological Study of High-Grade Serous Carcinoma Presenting as Primary Peritoneal Carcinoma

Komiyama, S., Nishijima, Y., Kondo, H., Nomura, H., Yamaguchi, S., Futagami, M., Arai, H., Yokoyama, Y., Suzuki, N., Mikami, M., Kubushiro, K., Aoki, D., Udagawa, Y. and Nishimura, R.

Int J Gynecol Cancer 28 ( 4 ) 657 - 665 2018.05

ISSN 1048-891X

OBJECTIVE: We conducted a multicenter clinicopathological study to characterize patients with high-grade serous carcinoma presenting as primary peritoneal carcinoma (clinical PPC). METHODS: At 9 sites in Japan, patients with clinical PPC diagnosed according to Gynecologic Oncology Group criteria were enrolled retrospectively. The Gynecologic Oncology Group criteria allow for minor ovarian involvement by high-grade serous carcinoma. There was no systematic detailed histopathological review of the fallopian tubes to determine whether they were involved by serous carcinoma. RESULTS: There were 139 patients and 64% were aged 60 years or older. Median pretreatment serum CA-125 was 1653.5 IU/mL. Pretreatment performance status was poor in more than 50%, endometrial cytology was positive in 40.3%, and the preoperative clinical diagnosis was correct in 72.7%. Primary debulking surgery was performed in 36% of patients, whereas 64% underwent neoadjuvant chemotherapy (NAC) with interval debulking surgery (IDS). The main tumor sites were the upper abdomen (greater omentum), extrapelvic peritoneum, mesentery, and diaphragm. Lymph node metastasis was found in 46.8% of patients undergoing systematic retroperitoneal node dissection. The optimal surgery rate was 32.0% with primary debulking surgery versus 53.9% with NAC and IDS (P = 0.0139). The response rate was 82.0% with NAC and 80.6% with postoperative chemotherapy. Median progression-free survival was 19.0 months and median overall survival was 41.0 months. Multivariate analysis showed that prognostic factors for progression-free survival were NAC and residual tumor diameter after debulking surgery, whereas the only prognostic factor for overall survival was the residual tumor diameter. CONCLUSIONS: This study identified various characteristics of clinical PPC. Neoadjuvant chemotherapy with IDS is a reasonable treatment strategy, and complete debulking surgery is optimum.

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Screening for Lynch syndrome using risk assessment criteria in patients with ovarian cancer

Takeda, T., Tsuji, K., Banno, K., Yanokura, M., Kobayashi, Y., Tominaga, E. and Aoki, D.

J Gynecol Oncol 29 ( 3 ) e29 2018.05

ISSN 2005-0380

OBJECTIVE: Lynch syndrome is a cancer predisposition syndrome caused by germline mutation of DNA mismatch repair (MMR) genes. Lynch syndrome only causes about 0.4% of cases of ovarian cancer, which suggests that universal screening may not be cost-efficient. However, the frequency of Lynch syndrome in ovarian cancer is unclear in the Asian population. The goal of the study was to investigate a screening strategy using family history. METHODS: The subjects were 129 patients with ovarian cancer. Clinical and family history were collected using a self-administered questionnaire, and Society of Gynecologic Oncology (SGO) criteria 2007 and PREMM(5) were used for risk assessment. Microsatellite instability, immunohistochemistry, and methylation of MMR genes were analyzed. RESULTS: Of the 129 cases, 25 (19.4%) met the SGO criteria, and 4 of these 25 had MSI-high and MMR deficiency. Two cases had loss of MSH2 and MSH6, indicating MSH2 mutation, and the other two had loss of MLH1 and PMS2, including one without MLH1 methylation indicating MLH1 mutation. These results show that screening using family history can detect Lynch syndrome in 12.0% (3/25) of ovarian cancer cases. The 3 cases were positive for PREMM(5), but negative for Amsterdam II criteria and revised Bethesda guidelines. Genetic testing in one case with MSH2 and MSH6 deficiency confirmed the diagnosis of Lynch syndrome with MSH2 mutation. CONCLUSION: This is the first study of screening for Lynch syndrome in ovarian cancer using clinical and family history in an Asian population. This approach may be effective for diagnosis in these patients.

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妊娠糖尿病管理中の低カリウム性四肢麻痺を契機に検出されたCushing症候群合併妊娠の1例

AOKI DAISUKE

東京産科婦人科学会会誌 67 ( 2 ) 280 - 283 2018.05

Joint Work

第59回日本婦人科腫瘍学会学術講演会記録婦人科腫瘍医のためのがん薬物療法総論

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 36 ( 2 ) 197 - 205 2018.04

Joint Work

腹腔鏡下子宮筋腫核出術におけるDouglas窩より筋腫摘出法の検討

AOKI DAISUKE

東京産科婦人科学会会誌 67 ( 2 ) 149 - 153 2018.04

Joint Work

各論：遺伝性婦人科腫瘍

AOKI DAISUKE

最新醫學 73 ( 3 ) 374 - 379 2018.03

Re: Starting a uterus transplantation service: notes from a small island

Kisu, I., Matoba, Y., Banno, K. and Aoki, D.

Bjog 125 ( 4 ) 515 - 516 2018.03

ISSN 1470-0328

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Impact of institutional accreditation by the Japan Society of Gynecologic Oncology on the treatment and survival of women with cervical cancer

Mikami, M., Shida, M., Shibata, T., Katabuchi, H., Kigawa, J., Aoki, D. and Yaegashi, N.

J Gynecol Oncol 29 ( 2 ) e23 2018.03

ISSN 2005-0380

OBJECTIVE: The Japan Society of Gynecologic Oncology (JSGO) initiated a nation-wide training system for the education and certification for gynecologic oncologists in 2005. To assess the impact of the quality of the JSGO-accredited institutions, JSGO undertook an analysis of the Uterine Cervical Cancer Registry of the Japan Society of Obstetrics and Gynecology (JSOG) to determine the effectiveness of the JSGO-accredited institutions on the treatment and survival of women with cervical cancer. METHODS: The effectiveness of 119 JSGO-accredited institutions and 125 non-JSGO-accredited institutions on the treatment and survival of women with cervical cancer were compared by analyzing the tumor characteristics, treatment patterns, and survival outcomes of women with stage T1B-T4 cervical cancer utilizing the data in the JSOG nation-wide registry for cervical cancer (2006-2009). RESULTS: A total of 14,185 eligible women were identified: 10,920 (77.0%) cases for 119 JSGO-accredited institutions and 3,265 (23.0%) cases for 125 non-accredited institutions. A multivariate analysis showed that age, stage, histology type, and treatment pattern were independently associated with mortality. Moreover, women who received treatment at the JSGO-accredited institutions had a significantly decreased mortality risk compared to non-accredited institutions (adjusted hazard ratio [aHR]=0.843; 95% confidence interval [CI]=0.784-0.905). Similar findings on multivariate analysis were seen among subset of women who received surgery alone (aHR=0.552; 95% CI=0.393-0.775) and among women who received radiotherapy (aHR=0.845; 95% CI=0.766-0.931). CONCLUSION: Successful implementation of gynecologic oncology accrediting institution was associated with improved survival outcome of women with cervical cancer in Japan.

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The 5th Biennial Meeting of the Asian Society of Gynecologic Oncology, November 30th to December 2nd, 2017

Tominaga, E., Kobayashi, Y. and Aoki, D.

J Gynecol Oncol 29 ( 2 ) e33 2018.03

ISSN 2005-0380

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Is repeated high-dose medroxyprogesterone acetate (MPA) therapy permissible for patients with early stage endometrial cancer or atypical endometrial hyperplasia who desire preserving fertility?

Yamagami, W., Susumu, N., Makabe, T., Sakai, K., Nomura, H., Kataoka, F., Hirasawa, A., Banno, K. and Aoki, D.

J Gynecol Oncol 29 ( 2 ) e21 2018.03

ISSN 2005-0380

OBJECTIVE: Reports on the repeated administration of medroxyprogesterone acetate (MPA) for intrauterine recurrence after fertility-preserving therapy for atypical endometrial hyperplasia (AEH) and early grade 1 endometrioid carcinoma (G1) are lacking. We aimed to clarify the outcomes of repeated MPA therapy in cases of intrauterine recurrence after fertility-preserving therapy with MPA against AEH/early G1. METHODS: Patients with AEH or stage IA well-differentiated endometrioid carcinoma without myometrial invasion who underwent first-line MPA therapy for primary lesions or intrauterine recurrence were divided into initial treatment and repeated treatment groups (162 and 82 patients, respectively). Oral MPA administration (400-600 mg/day) was continued until pathological tumor disappearance. Data regarding clinicopathological factors, adverse events, and outcomes following the initial and repeated hormonal treatments were extracted from medical records and analyzed. RESULTS: Complete response rates in the initial and repeated treatment groups were 98.5% and 96.4%, respectively, among patients with AEH, and were 90.7% and 98.1%, respectively, among patients with G1. In the initial treatment group, 5-year recurrence-free survival (RFS) rates were 53.7% and 33.2% among patients with AEH and G1, respectively. In the repeated treatment group, RFS rates were 14.0% and 11.2% among patients with AEH and G1, respectively. Among patients with AEH, the pregnancy rate tended to be lower in the repeated treatment group than in the initial treatment group (11.1% vs. 29.2%; p=0.107), while no significant group difference was observed among patients with G1 (20.8% vs. 22.7%). CONCLUSION: Repeated treatment is sufficiently effective for intrauterine recurrence after hormonal therapy for AEH/early G1.

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ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death

Ueno, M., Shiomi, T., Mochizuki, S., Chijiiwa, M., Shimoda, M., Kanai, Y., Kataoka, F., Hirasawa, A., Susumu, N., Aoki, D. and Okada, Y.

Cancer Sci (Cancer Science) 109 ( 2 ) 471 - 482 2018.02

ISSN 1347-9032

ADAMs (a disintegrin and metalloproteinases) are involved in various biological events such as cell adhesion, migration and invasion, membrane protein shedding and proteolysis. However, there have been no systematic studies on the expression of ADAMs in human ovarian carcinomas. We therefore examined mRNA expression of all the proteolytic ADAM species including ADAM8, 9, 10, 12, 15, 17, 19, 20, 21, 28, 30, 33 and ADAMDEC1 in human ovarian carcinomas, and found that prototype membrane-anchored ADAM9m, but not secreted isoform ADAM9s, is significantly over-expressed in carcinomas than in control non-neoplastic ovarian tissue. Among the histological subtypes of serous, endometrioid, mucinous and clear cell carcinomas, ADAM9m expression was highest in clear cell carcinomas. Immunohistochemistry showed that all the clear cell carcinoma samples displayed ADAM9m primarily on the carcinoma cell membrane. By immunoblotting, ADAM9m was detected mainly in an active form in the clear cell carcinoma tissues. When two clear cell carcinoma cell lines (RMG-I and TOV21G cells) with ADAM9m expression were treated with cisplatin, viability was significantly reduced and apoptosis increased in ADAM9m knockdown cells compared with mock transfectants. In addition, treatment of the cells with neutralizing anti-ADAM9m antibody significantly decreased viability compared with non-immune IgG, whereas ADAM9m over-expression significantly increased viability compared with mock transfectants. Our data show, to the best of our knowledge, for the first time, that ADAM9m is over-expressed in an activated form in human ovarian clear cell carcinomas, and suggest that ADAM9m plays a key role in cisplatin resistance.

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Radiation-induced angiosarcoma of the omentum diagnosed by laparoscopy: A case report

Kunitomi, H., Banno, K., Iseki, H., Sera, A., Miyauchi, A., Kobayashi, Y., Hayashi, S., Tominaga, E., Sasaki, A., Kawaida, M., Kameyama, K. and Aoki, D.

Mol Clin Oncol 8 ( 2 ) 264 - 268 2018.02

ISSN 2049-9450

Angiosarcoma is a rare malignant tumor with an aggressive clinical course and a poor prognosis. Intraperitoneal angiosarcoma, especially originating from the omentum, is extremely rare. We report a case of radiation-induced angiosarcoma of the omentum that arose in a 38-year-old female seven years after concurrent chemoradiotherapy for cervical cancer. The primary tumor was unknown until diagnostic laparoscopy revealed an unresectable omental mass. Pathological examination revealed high-grade malignant cells positive for endothelial markers. Although the small number of cases limits the consensus on optimal therapy for advanced angiosarcoma, the patient was managed successfully by taxane-based chemotherapy, leading to complete response and consequent complete cytoreductive surgery. Our report is the fifth case of radiation-induced angiosarcoma of the omentum, and all have developed after treatment for gynecologic cancer. Although very rare, this complication should be considered after radiation therapy in cancer treatment, particularly given the increasing importance of this therapy.

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Erratum: Recent advances in the molecular mechanisms of Mayer-Rokitansky-Kuster-Hauser syndrome

Watanabe, K., Kobayashi, Y., Banno, K., Matoba, Y., Kunitomi, H., Nakamura, K., Adachi, M., Umene, K., Kisu, I., Tominaga, E. and Aoki, D.

Biomed Rep 8 ( 1 ) 106 2018.01

ISSN 2049-9434

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HPV検査の活用法

AOKI DAISUKE

臨床婦人科産科 72 ( 1 ) 150 - 157 2018.01

Joint Work

Phase II basket trial of perifosine monotherapy for recurrent gynecologic cancer with or without PIK3CA mutations

Hasegawa K, Kagabu M, Mizuno M, Oda K, Aoki D, Mabuchi S, Kamiura S, Yamaguchi S, Aoki Y, Saito T, Yunokawa M, Takehara K, Okamoto A, Ochiai K, Kimura T

Invest New Drugs 35 ( 6 ) 800 - 812 2017.12

Research paper (scientific journal), Joint Work

SIM2l attenuates resistance to hypoxia and tumor growth by transcriptional suppression of HIF1A in uterine cervical squamous cell carcinoma

Nakamura K, Komatsu M, Chiwaki F, Takeda T, Kobayashi Y, Banno K, Aoki D, Yoshida T, Sasaki H

Sci Rep 7 ( 1 ) 14574 2017.11

Research paper (scientific journal), Joint Work

Aberrant chromatin remodeling in gynecological cancer

Okawa R, Banno K, Iida M, Yanokura M, Takeda T, Iijima M, Kunitomi-Irie H, Nakamura K, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D

Oncol Lett 14 ( 5 ) 5107 - 5113 2017.11

Research paper (scientific journal), Joint Work

Efficacy and safety of dose-dense paclitaxel plus carboplatin as neoadjuvant chemotherapy for advanced ovarian, fallopian tube or peritoneal cancer

Yoshihama T, Nomura H, Iwasa N, Kataoka F, Hashimoto S, Nanki Y, Hirano T, Makabe T, Sakai K, Yamagami W, Hirasawa A, Aoki D

Jpn J Clin Oncol 47 ( 11 ) 1019 - 1023 2017.11

Research paper (scientific journal), Joint Work

Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer

Hirasawa A, Imoto I, Naruto T, Akahane T, Yamagami W, Nomura H, Masuda K, Susumu N, Tsuda H, Aoki D

Oncotarget 8 ( 68 ) 112258 - 112267 2017.11

Research paper (scientific journal), Joint Work

Harmonising clinical trials within the Gynecologic Cancer InterGroup: consensus and unmet needs from the Fifth Ovarian Cancer Consensus Conference

Bookman MA, Okamoto A, Stuart G, Yanaihara N, Aoki D, Bacon M, Fujiwara K, González-Martín A, Harter P, Kim JW, Ledermann J, Pujade-Lauraine E, Quinn M, Ochiai K; 5th Ovarian Cancer Consensus Conference

Ann Oncol 8 ( suppl 8 ) viii30 - viii35 2017.11

Joint Work, Accepted

Allowable warm ischemic time and morphological and biochemical changes in uterine ischemia/reperfusion injury in cynomolgus macaque: a basic study for uterus transplantation

Kisu, I., Umeneo, K., Adachi, M., Emoto, K., Nogami, Y., Banno, K., Itagaki, I., Kawamoto, I., Nakagawa, T., Narita, H., Yoshida, A., Tsuchiya, H., Ogasawara, K. and Aoki, D.

Hum Reprod 32 ( 10 ) 2026 - 2035 2017.10

Research paper (scientific journal), Joint Work, ISSN 0268-1161

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Phase III trial to confirm the superiority of pelvic and para-aortic lymphadenectomy to pelvic lymphadenectomy alone for endometrial cancer: Japan Clinical Oncology Group Study 1412 (SEPAL-P3)

Watari H, Katayama H, Shibata T, Ushijima K, Satoh T, Onda T, Aoki D, Fukuda H, Yaegashi N, Sakuragi N; Gynecologic Cancer Study Group of the Japan Clinical Oncology Group

Jpn J Clin Oncol 47 ( 10 ) 986 - 990 2017.10

Research paper (scientific journal), Joint Work

Mid-trimester residual cervical length and the risk of preterm birth in pregnancies after abdominal radical trachelectomy: a retrospective analysis

Kasuga, Y., Miyakoshi, K., Nishio, H., Akiba, Y., Otani, T., Fukutake, M., Ikenoue, S., Ochiai, D., Matsumoto, T., Tanaka, K., Minegishi, K., Kuji, N., Roberts, R., Aoki, D. and Tanaka, M.

Bjog 124 ( 11 ) 1729 - 1735 2017.10

Research paper (scientific journal), Joint Work, ISSN 1470-0328

OBJECTIVE: To investigate the association between mid-trimester residual cervical length (CL) and the risk of preterm birth in pregnancies after abdominal radical trachelectomy (RT). DESIGN: Retrospective cohort study. SETTING: University hospital. POPULATION: A total of 33 deliveries after 22 weeks' gestation in 30 women who underwent abdominal RT including prophylactic cervical cerclage and perinatal care between January 2002 and May 2016. METHODS: The association between mid-trimester residual CL (the distance between the cerclage and the external cervical os) and gestational age at delivery was investigated. Receiver-operating characteristics (ROC) curve analysis was performed to estimate the optimal cut-off values of the mid-trimester residual CL for the prediction of preterm birth. MAIN OUTCOME MEASURES: Preterm birth before 34 weeks' gestation. RESULTS: Mid-trimester residual CL showed a significant correlation with gestational age at delivery (r = 0.36, P < 0.05). There was a significant difference in residual CL between women who did and those who did not give birth before 34 weeks (P < 0.05). Mid-trimester residual CL < 13 mm was a good predictor of birth before 34 weeks, with a sensitivity of 67%, specificity of 75%, positive predictive value of 55% and negative predictive value of 86% (area under ROC curve, 0.75). CONCLUSIONS: Mid-trimester residual CL is significantly correlated with gestational age at delivery. Residual CL assessment could be used to reassure physicians and women that there is only a small chance of preterm birth in pregnancies after abdominal RT. TWEETABLE ABSTRACT: Mid-trimester residual cervical length is a good predictor of preterm birth after radical trachelectomy.

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CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening: Design, methods and baseline data of 18,471 women

Morisada T, Teramoto K, Takano H, Sakamoto I, Nishio H, Iwata T, Hashi A, Katoh R, Okamoto A, Sasaki H, Nakatani E, Teramukai S, Aoki D

Cancer Epidemiol 50 ( Pt A ) 60 - 67 2017.10

Research paper (scientific journal), Joint Work

治療抵抗性排卵障害を契機に卵巣セルトリ・ライディッヒ細胞腫の診断に至った1例

國富晴子，升田博隆，瀬田康弘，飯島茂異人，片倉慧美，竹田貴，吉政佑之，中村加奈子，三木史恵，青木大輔，田中　守

東京産科婦人科学会会誌 66 ( 44 ) 640 - 646 2017.10

Research paper (scientific journal), Joint Work, Accepted

子宮動脈塞栓術が奏功した帝王切開瘢痕部妊娠の1例

荘慎太郎，松本直，佐藤佑，大谷利光，秋葉洋平，春日義史，池ノ上学，落合大吾，宮越　敬，田中　守，青木大輔

東京産科婦人科学会会誌 66 ( 4 ) 647 - 651 2017.10

Research paper (scientific journal), Joint Work

Final report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology, on a fact-finding questionnaire on the status of treatment of hereditary breast and ovarian cancer syndrome in Japan

Satoh T, Takamatsu K, Takeshima N, Kobayashi H, Aoki D, Suzuki N

J Obstet Gynaecol Res 43 ( 9 ) 1377 - 1380 2017.09

Research paper (scientific journal), Joint Work

New use of microsatellite instability analysis in endometrial cancer

Kunitomi, H., Banno, K., Yanokura, M., Takeda, T., Iijima, M., Nakamura, K., Iida, M., Adachi, M., Watanabe, K., Matoba, Y., Kobayashi, Y., Tominaga, E. and Aoki, D.

Oncol Lett 14 ( 3 ) 3297 - 3301 2017.09

Research paper (scientific journal), Joint Work, ISSN 1792-1074

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A Comparison of Dye Versus Fluorescence Methods for Sentinel Lymph Node Mapping in Endometrial Cancer

Yamagami, W., Susumu, N., Kataoka, F., Makabe, T., Sakai, K., Ninomiya, T., Wada, M., Nomura, H., Hirasawa, A., Banno, K., Nakahara, T., Kameyama, K. and Aoki, D.

Int J Gynecol Cancer 27 ( 7 ) 1517 - 1524 2017.09

Research paper (scientific journal), Joint Work, ISSN 1048-891X

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治療薬解説　PARP阻害薬

AOKI DAISUKE

カレントテラピー 35 ( 9 ) 74 - 77 2017.09

Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer

Kobayashi Y, Kashima H, Rahmanto YS, Banno K, Yu Y, Matoba Y, Watanabe K, Iijima M, Takeda T, Kunitomi H, Iida M, Adachi M, Nakamura K, Tsuji K, Masuda K, Nomura H, Tominaga E, Aoki D

Oncotarget 8 ( 42 ) 72147 - 72156 2017.09

Research paper (scientific journal), Joint Work

Whole-genome sequencing revealed novel prognostic biomarkers and promising targets for therapy of ovarian clear cell carcinoma

Itamochi, H., Oishi, T., Oumi, N., Takeuchi, S., Yoshihara, K., Mikami, M., Yaegashi, N., Terao, Y., Takehara, K., Ushijima, K., Watari, H., Aoki, D., Kimura, T., Nakamura, T., Yokoyama, Y., Kigawa, J. and Sugiyama, T.

Br J Cancer 117 ( 5 ) 717 - 724 2017.08

Research paper (scientific journal), Joint Work, ISSN 0007-0920

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Recent advances in the molecular mechanisms of Mayer-Rokitansky-Kuster-Hauser syndrome

Watanabe, K., Kobayashi, Y., Banno, K., Matoba, Y., Kunitomi, H., Nakamura, K., Adachi, M., Umene, K., Kisu, I., Tominaga, E. and Aoki, D.

Biomed Rep 7 ( 2 ) 123 - 127 2017.08

Research paper (scientific journal), Joint Work, ISSN 2049-9434

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遺伝性卵巣がん

AOKI DAISUKE

成人病と生活習慣病 47 ( 7 ) 861 - 866 2017.07

Joint Work

手術前禁忌薬（経口避妊薬、低用量エストロゲン－プロゲスチン配合薬）に関する医療安全対策

AOKI DAISUKE

東京産科婦人科学会会誌 66 ( 3 ) 424 - 428 2017.07

Research paper (scientific journal), Joint Work

Comparison Between Laparoscopy and Laparotomy in Systematic Para-Aortic Lymphadenectomy for Patients with Endometrial Cancer: A Retrospective Multicenter Study

Tanaka, T., Terai, Y., Hayashi, S., Aoki, D., Miki, M., Kobayashi, E., Kimura, T., Baba, T., Matsumura, N. and Ohmichi, M.

J Gynecol Surg 33 ( 3 ) 105 - 110 2017.06

Research paper (scientific journal), Joint Work, ISSN 1042-4067

Objective: Laparoscopic surgery has been developed worldwide due to its minimal invasion as well as noninferiority, compared with laparotomy. However, whether or not laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer is feasible and has advantages of various clinical factors, such as a short hospital stay, less blood loss, and faster recovery, compared with open surgery has not yet been clarified. The aim of this study was to compare a laparoscopic procedure with laparotomy for para-aortic lymphadenectomy for patients with endometrial cancer. Study Design: This was a retrospective multicenter study of laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer in five institutions. Materials and Methods: The current authors conducted a retrospective multicenter study of laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer. The study involved patients from five institutions in Japan between January 2008 and March 2016. Clinical data were compared with those of a laparotomic procedure performed around the same period. Results: A total of 54 patients in the laparoscopic group and 99 patients in the laparotomic group were analyzed. In the laparoscopic group, 21 patients had stage IA disease, 19 had stage IB disease, 5 had stage II disease, and 9 had stage III disease. In the laparotomic group, 35 patients had stage IA disease, 19 had stage IB disease, 9 had stage II disease, and 36 had stage III disease. There were no significant differences in characteristics between the groups, including age, body mass index, and histologic type. The mean operative time in the laparoscopic group was 483 +/- 102 minutes, while that in the laparotomic group was 481 +/- 106 minutes (p = 0.9). The laparoscopic group had less intraoperative blood loss (143 +/- 253 versus 988 +/- 694 mL; p < 0.01) and shorter hospital stays (8.4 +/- 5.7 versus 16.1 +/- 8.0 days; p < 0.01). The rates of intraoperative complications were not significantly different between the groups. No cases of ileus occurred in the laparoscopic group. Procedures for 2 of the 54 patients in the laparoscopic group were converted to laparotomy. The number of dissected pelvic lymph nodes (31.8 +/- 10.1 versus 39.9 +/- 15.9, p < 0.01) and para-aortic lymph nodes (26.2 +/- 10.9 versus 31.1 +/- 13.2; p = 0.02) were lower in the laparoscopic group than in the laparotomic group. The postoperative minimum level of hemoglobin was higher in the laparoscopic group than in the laparotomic group (10.4 +/- 1.1 g/dL versus 9.9 +/- 1.4 g/dL; p = 0.02). In contrast, the postoperative maximum level of C-reactive protein was lower in the laparoscopic group than in the laparotomic group (6.3 +/- 3.8 mg/dL versus 10.2 +/- 4.9 mg/dL; p < 0.01). The recurrence rate was not significantly different between the groups in the above time period (7.4% versus 14.3%; p = 0.2). Conclusions: Laparoscopic systematic para-aortic lymphadenectomy is feasible and can be substituted for laparotomic procedures for patients with early stage endometrial cancer. ( J GYNECOL SURG 33:105).

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遺伝性乳癌卵巣癌症候群と女性ヘルスケア

AOKI DAISUKE

更年期と加齢のヘルスケア 16 ( 1 ) 42 - 45 2017.06

Joint Work

Genome-wide DNA methylation sequencing reveals miR-663a is a novel epimutation candidate in CIMP-high endometrial cancer

Yanokura, M., Banno, K., Adachi, M., Aoki, D. and Abe, K.

Int J Oncol 50 ( 6 ) 1934 - 1946 2017.06

Research paper (scientific journal), Joint Work, ISSN 1019-6439

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医療機器に生じたトラブル

AOKI DAISUKE

産婦人科の実際 66 ( 6 ) 767 - 771 2017.06

Joint Work

Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. and Aoki, D.

Jpn J Clin Oncol 47 ( 5 ) 473 2017.05

Research paper (scientific journal), Joint Work, ISSN 0368-2811

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Clinical utility of a self-administered questionnaire for assessment of hereditary gynecologic cancer

Masuda, K., Hirasawa, A., Irie-Kunitomi, H., Akahane, T., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Kataoka, F., Tominaga, E., Banno, K., Susumu, N. and Aoki, D.

Jpn J Clin Oncol 47 ( 5 ) 401 - 406 2017.05

Research paper (scientific journal), Joint Work, ISSN 0368-2811

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一般病院における家族性腫瘍相談外来とハイリスク外来の開設－一般病院に求められる家族性腫瘍診療の意義についての考察－

AOKI DAISUKE

家族性腫瘍 16 ( 2 ) 38 - 43 2017.05

Joint Work

FDG-PET/CTによる転移診断の注意点は？

AOKI DAISUKE

臨床婦人科産科 2017増刊号（産婦人科画像診断トレーニング） 71 ( 4 ) 293 - 297 2017.04

Joint Work

Enhanced fucosylation of GA1 in the digestive tracts of X-ray-irradiated mice

Iwamori, M., Tanaka, K., Adachi, S., Aoki, D. and Nomura, T.

Glycoconj J 34 ( 2 ) 163 - 169 2017.04

Research paper (scientific journal), Joint Work, ISSN 0282-0080

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Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Nanki, Y., Chiyoda, T., Kataoka, F., Nomura, H., Nakadaira, N., Iwasa, N., Hashimoto, S., Arima, H., Susumu, N. and Aoki, D.

J Obstet Gynaecol Res 43 ( 4 ) 744 - 748 2017.04

Research paper (scientific journal), Joint Work, ISSN 1341-8076

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胸水貯留をきたしたホルモン補充周期融解胚移植後の全胞状奇胎の1例

玉川真澄，内田明花，佐藤佑，片倉慧美，吉政佑之，日原華子，冨里祥子，中林章，升田博隆，内田浩，丸山哲夫，田中守，青木大輔

東京産科婦人科学会会誌 66 ( 2 ) 316 - 321 2017.04

Research paper (scientific journal), Joint Work

Clinical statistics of gynecologic cancers in Japan

Yamagami, W., Nagase, S., Takahashi, F., Ino, K., Hachisuga, T., Aoki, D. and Katabuchi, H.

J Gynecol Oncol 28 ( 2 ) e32 2017.03

Research paper (scientific journal), Joint Work, ISSN 2005-0380

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Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer

Iijima, M., Banno, K., Okawa, R., Yanokura, M., Iida, M., Takeda, T., Kunitomi-Irie, H., Adachi, M., Nakamura, K., Umene, K., Nogami, Y., Masuda, K., Tominaga, E. and Aoki, D.

Oncol Lett 13 ( 3 ) 1063 - 1070 2017.03

Research paper (scientific journal), Joint Work, ISSN 1792-1074

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UGT1A1 polymorphism as a prognostic indicator of stage I ovarian clear cell carcinoma patients treated with irinotecan

Yoshihama, T., Hirasawa, A., Nomura, H., Akahane, T., Nanki, Y., Yamagami, W., Kataoka, F., Tominaga, E., Susumu, N., Mushiroda, T. and Aoki, D.

Jpn J Clin Oncol 47 ( 2 ) 170 - 174 2017.02

Research paper (scientific journal), Joint Work, ISSN 0368-2811

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Effective Selection of a Well-Differentiated Type of Human Uterine Endometrial Carcinoma Cells by Transfection of the Sulfotransferase Gene and Possible Association of Sulfoglycolipids With Well-Differentiated Phenotypes

Tanaka, K., Ishiwata, I., Kubushiro, K., Mikami, M., Aoki, D., Kiguchi, K. and Iwamori, M.

Int J Gynecol Cancer 27 ( 2 ) 267 - 273 2017.02

Research paper (scientific journal), Joint Work, ISSN 1048-891X

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A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 cases

Kuji, S., Watanabe, R., Sato, Y., Iwata, T., Hirashima, Y., Takekuma, M., Ito, I., Abe, M., Nagashio, R., Omae, K., Aoki, D. and Kameya, T.

Gynecol Oncol 144 ( 2 ) 384 - 390 2017.02

Research paper (scientific journal), Joint Work, ISSN 0090-8258

OBJECTIVE: High-grade neuroendocrine carcinoma of uterine cervix (HGNCUC) has been recognized as a highly malignant tumor. Therapeutic strategy specific to neuroendocrine (NE) tumors needs to be considered, but some cases wouldn't allow simple final diagnoses. Insulinoma-associated protein 1 (INSM1), which is a zinc-finger transcription factor related to NE differentiation, is frequently expressed in NE tumors. We investigated the association between INSM1 and HGNCUC, and the possibility of INSM1 as a useful NE marker. METHODS: Thirty-seven cases of formalin-fixed and paraffin-embedded HGNCUCs were evaluated immunohistochemically for conventional NE markers and INSM1. We also surveyed polymerase chain reactions and examined the frequency and the genotype of human papillomavirus (HPV) infections. RESULTS: In HGNCUC, chromogranin A, synaptophysin and neural cell adhesion molecule (NCAM) were expressed in 86%, 86% and 68%, respectively. In addition, INSM1 was detected in 95%. Positivity for INSM1 was clearly evaluated histologically, because the intensity of nuclear staining on positive cells was high and nonspecific reactions were minimal. In uni- and multivariate analyses of prognostic factors on stage I and II surgical cases, the association between INSM1 expression and prognosis was insignificant. We confirmed 72% of 29 examined cases had high risk HPV infections (type 16, 14%; type 18, 86%). CONCLUSIONS: This study has clarified that INSM1 is closely related to the development of HGNCUC, and a useful new NE marker in conducting its correct and rapid diagnosis.

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Carcinoma of the lower uterine segment diagnosed with Lynch syndrome based on MSH6 germline mutation: A case report

Adachi, M., Banno, K., Masuda, K., Yanokura, M., Iijima, M., Takeda, T., Kunitomi, H., Kobayashi, Y., Yamagami, W., Hirasawa, A., Kameyama, K., Sugano, K. and Aoki, D.

J Obstet Gynaecol Res 43 ( 2 ) 416 - 420 2017.02

Research paper (scientific journal), Joint Work, ISSN 1341-8076

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当科で経験した子宮頸部漿液性腺癌の2例

黒田由香，仲村勝，飯島朋子，竹田貴，吉政佑之，宮内安澄，岩田卓，田中京子，冨永英一郎，進伸幸，田中守，青木大輔

東京産科婦人科学会会誌 66 ( 1 ) 92 - 96 2017.01

Research paper (scientific journal), Joint Work

子宮頸がん

AOKI DAISUKE

HORMONE FRONTIER IN GYNECOLOGY 23 ( 4 ) 37 - 39 2016.12

Joint Work

Differential micro ribonucleic acid expression profiling in ovarian endometrioma with leuprolide acetate treatment

Kiba, A., Banno, K., Yanokura, M., Asada, M., Nakayama, Y., Aoki, D. and Watanabe, T.

J Obstet Gynaecol Res 42 ( 12 ) 1734 - 1743 2016.12

Research paper (scientific journal), Joint Work, ISSN 1341-8076

AIM: Micro ribonucleic acids (miRNAs) play an important pathological role in endometriosis. Leuprolide acetate, an analog of gonadotropin-releasing hormone, is widely used to treat endometriosis; however, the molecular mechanisms involved in endometriotic tissue regression remain unclear. We performed miRNA expression profiling of clinical ovarian endometrioma to obtain insight into the effects of leuprolide acetate treatment. METHODS: We obtained clinical samples from nine normal eutopic endometrium, eight ovarian endometriotic, and 12 leuprolide acetate-treated endometriotic tissues. We compared the miRNA expression profiles of the three groups by performing TaqMan Array MicroRNA Card and bioinformatic analysis. RESULTS: Two miRNAs, miR-939 and miR-154, were upregulated in endometriotic tissue and downregulated in leuprolide acetate-treated endometriotic tissue. Five miRNAs (miR-146a, miR-142-3p, miR-136*, miR-125b-1* and miR-15b*) were unchanged in endometriotic tissue but were upregulated under leuprolide acetate treatment. Ingenuity pathway analysis using predicted target genes for the seven identified miRNAs suggested the involvement of a range of pathways, including axonal guidance, bone morphogenetic protein, phosphatase and tensin homolog and nitric oxide signaling; molecular mechanisms of cancer; and the adipogenesis and signal transducer and activator of transcription 3 (STAT3) pathways. CONCLUSIONS: To our knowledge, this is the first report profiling the miRNAs of endometrioma under leuprolide acetate treatment. The expression of seven miRNAs was modulated, concomitant with the disease state. This result gives new insight into the effects of leuprolide acetate treatment. Further investigation using quantitative reverse transcriptase-polymerase chain reaction and immunohistochemistry will allow us to validate the results of this study and to explore new therapeutic targets and biomarkers of endometriosis.

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子宮移植

AOKI DAISUKE

産婦人科の実際 65 ( 12 ) 1587 - 1594 2016.11

Joint Work

卵巣明細胞腺癌合併妊娠に対して待機的治療を行った2症例

高橋孝幸，野村弘行，二宮委美，岩佐尚美，中平直希，松本直，山上亘，片岡史夫，宮越敬，田中守，青木大輔

関東連合産科婦人科学会誌 53 ( 4 ) 633 - 639 2016.11

Research paper (scientific journal), Joint Work

Methylation Analysis of DNA Mismatch Repair Genes Using DNA Derived from the Peripheral Blood of Patients with Endometrial Cancer: Epimutation in Endometrial Carcinogenesis

Takeda, T., Banno, K., Yanokura, M., Adachi, M., Iijima, M., Kunitomi, H., Nakamura, K., Iida, M., Nogami, Y., Umene, K., Masuda, K., Kobayashi, Y., Yamagami, W., Hirasawa, A., Tominaga, E., Susumu, N. and Aoki, D.

Genes (Basel) 7 ( 10 ) 2016.10

Research paper (scientific journal), Joint Work, ISSN 2073-4425

Germline mutation of DNA mismatch repair (MMR) genes is a cause of Lynch syndrome. Methylation of MutL homolog 1 (MLH1) and MutS homolog 2 (MSH2) has been detected in peripheral blood cells of patients with colorectal cancer. This methylation is referred to as epimutation. Methylation of these genes has not been studied in an unselected series of endometrial cancer cases. Therefore, we examined methylation of MLH1, MSH2, and MSH6 promoter regions of peripheral blood cells in 206 patients with endometrial cancer using a methylation-specific polymerase chain reaction (MSP). Germline mutation of MMR genes, microsatellite instability (MSI), and immunohistochemistry (IHC) were also analyzed in each case with epimutation. MLH1 epimutation was detected in a single patient out of a total of 206 (0.49%)-1 out of 58 (1.72%) with an onset age of less than 50 years. The patient with MLH1 epimutation showed high level MSI (MSI-H), loss of MLH1 expression and had developed endometrial cancer at 46 years old, complicated with colorectal cancer. No case had epimutation of MSH2 or MSH6. The MLH1 epimutation detected in a patient with endometrial cancer may be a cause of endometrial carcinogenesis. This result indicates that it is important to check epimutation in patients with endometrial cancer without a germline mutation of MMR genes.

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早期子宮頸癌に対する機能温存手術としての腹式広汎性子宮頸部摘出術

AOKI DAISUKE

産婦人科の実際 65 ( 11 ) 1547 - 1550 2016.10

Joint Work

Feasibility study on combination chemotherapy using nogitecan hydrochloride (topotecan) and cisplatin for patients with metastatic, persistent, or recurrent uterine cervical cancer

Shimada, M., Sato, S., Oishi, T., Itamochi, H., Kigawa, J., Takeshima, N., Aoki, D., Aoki, Y., Nambu, Y. and Ochiai, K.

Int J Clin Oncol 21 ( 5 ) 969 - 974 2016.10

Research paper (scientific journal), Joint Work, ISSN 1341-9625

BACKGROUND: The standard chemotherapeutic regimen for stage IVB, persistent, or recurrent uterine cervical cancer is platinum-based combination chemotherapy such as cisplatin (CDDP)/paclitaxel and CDDP/nogitecan hydrochloride (NGT, topotecan). Because it is unclear whether the CDDP/NGT combination chemotherapy is tolerable for Japanese patients, we conducted the present study to assess the feasibility of CDDP/NGT combination chemotherapy. METHODS: Between June 2012 and April 2014, 15 patients with stage IVB, persistent, or recurrent uterine cervical cancer were enrolled in this study. Patients underwent six cycles of NGT at a dose of 0.75 mg/m2, followed immediately by CDDP at a dose of 50 mg/m2 on day 1 by intravenous infusion, and then NGT at a dose of 0.75 mg/m2 on days 2 and 3. RESULTS: Of 15 patients, 9 patients underwent at least 6 cycles of NGT/CDDP combination chemotherapy. Of a total of 83 cycles, 70 cycles (84.3 %) of NGT/CDDP combination chemotherapy could be continued at the starting dose of NGT (0.75 mg/m2). Grade 3/4 hematological toxicities included leukopenia in 10 patients (66.7 %), neutropenia in 15 (100 %), anemia in 6 (40.0 %), thrombocytopenia in 4 (26.7 %), and febrile neutropenia in 4 (26.7 %). The response rate according to RECIST was 27 % (3/11), with partial response in 3 patients. CONCLUSIONS: NGT/CDDP combination chemotherapy may be a tolerable and effective regimen for Japanese patients with stage IVB, persistent, or recurrent uterine cervical cancer. Based on the results of this study, NGT/CDDP combination chemotherapy was approved in Japan in November 2015.

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Enhanced expression of unique gangliosides with GM2-determinant in human uterine cervical carcinoma-derived cell lines

Tanaka, K., Miyazawa, M., Mikami, M., Aoki, D., Kiguchi, K. and Iwamori, M.

Glycoconj J 33 ( 5 ) 745 - 54 2016.10

Research paper (scientific journal), Joint Work, ISSN 0282-0080

Monoclonal antibody YHD-06 generated by immunization with GM2 reacted with gangliosides with GM2-determinant, i.e., GM2, GalNAc-GM1b and GalNAc-GD1a, among which GalNAc-GD1a was characterized as an antigen of autoimmune peripheral neuropathies including Guillain-Barre syndrome. When glycolipids were examined by TLC-immunostaining with YHD-06 in seven human cervical carcinoma-derived cell lines, GM2 was found in all cell lines, amounting to 15.5 % to 57.5 % of total gangliosides. Whereas GalNAc-GD1a was present in three cell lines, amounting to 5.4-17.5 % of total gangliosides, and GalNAc-GM1b in four cell lines in amounts of less than 2 %. The elevated amounts of gangliosides with GM2 determinant were closely correlated with the relative intensities of gene expression of GalNAc transferase, this being characteristic of cervical carcinoma-derived cells. However, in tissues from patients with several histological types of cervical carcinomas, GM3 was ubiquitously expressed in amounts of more than 66 % of total gangliosides, GM2 was expressed in only five of 15 tissues, and both GalNAc-GM1b and GalNAc-GD1a were not even detected in trace amounts. Since GM1 was detected in all tissues in amounts of less than 0.06 mug/mg dried tissue, all cervical carcinoma tissues were revealed to exhibit GM2 synthesis, indicating that enhanced synthesis of gangliosides with GM2 determinant is a characteristic of cultivated cells in vitro. Similarly, although I(3)SO3-GalCer was not present in the squamous cell carcinoma (SCC) tissues, SCC-derived cells selectively expressed II(3)SO3-LacCer. Since enhanced synthesis of GM2 has been reported in SV-40 virus-transfected fibroblasts, papilloma virus might be involved in the expression of GM2 in cervical carcinoma-derived cells.

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Comparison of methods using paraffin-embedded tissues and exfoliated cervical cells to evaluate human papillomavirus genotype attribution

Torii, Y., Fujii, T., Kukimoto, I., Saito, M., Iwata, T., Takahashi, H., Ichikawa, R., Kawai, S., Otani, S. and Aoki, D.

Cancer Sci 107 ( 10 ) 1520 - 1526 2016.10

Research paper (scientific journal), Joint Work, ISSN 1347-9032

Monitoring the attribution of human papillomavirus (HPV) genotypes to cervical precancerous lesions is essential in assessing the efficacy of HPV vaccines. To resolve the lack of studies comparing the HPV genotyping procedures used to estimate HPV genotype attribution, we undertook a retrospective cross-sectional study to determine the appropriate genotyping procedures for evaluating the potential efficacy of HPV vaccines. Three procedures, including two different genotyping methods, Clinichip HPV test (C-Chip) and modified GP5+/6+ PCR coupled to fluorescent bead sorter detection (MGP), using exfoliated cervical cells (C-Chip and C-MGP, respectively) or formalin-fixed paraffin-embedded tissues (F-MGP), were compared. The overall agreement in detecting high-risk HPV was 88.5-92.1% among the three procedures, and genotype-specific agreement was 83.9-100% for all pairwise comparisons. In cervical intraepithelial neoplasia grade 2/3 specimens, HPV16/18 attribution estimated with the hierarchical attribution method was consistent among the procedures: 52.3% (45/86) for C-Chip, 54.7% (47/86) for C-MGP, and 52.3% (45/86) for F-MGP (P = 0.81). HPV16/18/31/33/45/52/58 hierarchical attribution was 88.4% (76/86) with C-Chip, 86.0% (74/86) with C-MGP, and 83.7% (72/86) with F-MGP (P = 0.49). In cervical intraepithelial neoplasia grade 3 specimens, the corresponding hierarchical attribution was 96.4% (53/55) with C-Chip, 89.1% (49/55) with C-MGP, and 94.5% (52/55) with F-MGP (P = 0.27). Although F-MGP is theoretically a reliable method for determining HPV genotype attribution, it is acceptable to use C-Chip or C-MGP, coupled to the hierarchical attribution formula to correct the bias of multiple infections. These approaches using exfoliated cervical cells are practical for monitoring the efficacy of HPV vaccines.

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婦人科悪性腫瘍に脳梗塞を合併したTrousseau症候群5例の検討

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 34 ( 4 ) 620 - 625 2016.10

Joint Work

HPV併用検診の有効性検証

AOKI DAISUKE

産科と婦人科 83 ( 10 ) 1135 - 1141 2016.10

Joint Work

子宮体癌化学療法－JGOG２０４３

AOKI DAISUKE

産科と婦人科 83 ( 10 ) 1148 - 1153 2016.10

Joint Work

遺伝性腫瘍領域の新たな潮流

AOKI DAISUKE

実験医学 34 ( 16 ) 2671 - 2674 2016.10

Joint Work

Symptoms and effects of physical factors in Japanese middle-aged women

Yokota, M., Makita, K., Hirasawa, A., Iwata, T. and Aoki, D.

Menopause 23 ( 9 ) 974 - 83 2016.09

Research paper (scientific journal), Joint Work, ISSN 1072-3714

OBJECTIVE: The aim of the study was to clarify the prevalence and severity rates of symptoms and investigate whether symptoms varied in relation to body mass index (BMI). METHODS: The study group composed of 1,969 women, aged 40 to 60 years, who presented at our department from 1993 through 2014. The participation rate was 98%. The presence or absence of symptoms was evaluated by having the participants complete the Keio Questionnaire, a self-administered questionnaire. To allow the results to be compared according to ovarian function, serum levels of follicle-stimulating hormone and estradiol were measured. Participants were classified into three groups according to BMI: underweight, normal weight, and overweight. Symptoms were also compared among these subgroups. RESULTS: The most common symptom was general fatigue. Vasomotor symptoms differed significantly between pre- and postmenopause status. When symptoms were analyzed according to BMI, the severity rates of the following symptoms were significantly higher in the overweight group than in the normal weight and underweight groups: hot flushes, sweats, joint pain, numbness, and incontinence. On the contrary, the underweight group had significantly higher severities of cold constitution, nervousness, and wrinkled skin than did the other groups. In addition, an increase in BMI was associated with an increased severity of vasomotor symptoms. CONCLUSIONS: The prevalence and severities of shoulder stiffness, considered a characteristic symptom in Japanese women, were high. Increased BMI was shown to be associated with a higher severity of vasomotor symptoms, joint pain, nervousness, and urinary symptoms.

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Evaluation of allowable time and histopathological changes in warm ischemia of the uterus in cynomolgus monkey as a model for uterus transplantation

Adachi, M., Kisu, I., Nagai, T., Emoto, K., Banno, K., Umene, K., Nogami, Y., Tsuchiya, H., Itagaki, I., Kawamoto, I., Nakagawa, T., Ogasawara, K. and Aoki, D.

Acta Obstet Gynecol Scand 95 ( 9 ) 991 - 8 2016.09

Research paper (scientific journal), Joint Work, ISSN 0001-6349

INTRODUCTION: The objective of this study was to examine the allowable warm ischemic time and pathological changes due to ischemia and reperfusion injury in the uterus of the cynomolgus monkey as a model for uterus transplantation. MATERIAL AND METHODS: Six female cynomolgus monkeys were used in the study. The uterus was resected from the vaginal canal and connected through the bilateral ovarian and uterine arteries and veins only. One animal was used as a control. In the other five animals, the bilateral uterine and ovarian vessels were clamped for 0.5, 1, 2, 4 and 8 h, respectively. Biopsy of the smooth muscle tissue of corpus uteri was performed after each ischemic time and after subsequent reperfusion for 3 h. Biopsy samples were observed by light and electron microscopy. Menstruation recovery was monitored. RESULTS: There were no particular findings in both light and electron microscopy after ischemia for up to 2 h and after subsequent reperfusion. There were no marked changes after ischemia for 4 h, but dilated nuclear pores and rough endoplasmic reticulum swelling were found after reperfusion. These changes also occurred, along with mitochondrial swelling and cristae loss after ischemia for 8 h, and plasma membrane loss, nuclear fragmentation and chromatin condensation were found after reperfusion. Periodical menstruation restarted in all animals with ischemia up to 4 h, but the animal with ischemia for 8 h had amenorrhea and uterine atrophy. CONCLUSIONS: The uterus of the cynomolgus monkey tolerates warm ischemia for up to 4 h.

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Randomized Phase III Trial of Irinotecan Plus Cisplatin Compared With Paclitaxel Plus Carboplatin As First-Line Chemotherapy for Ovarian Clear Cell Carcinoma: JGOG3017/GCIG Trial

Sugiyama, T., Okamoto, A., Enomoto, T., Hamano, T., Aotani, E., Terao, Y., Suzuki, N., Mikami, M., Yaegashi, N., Kato, K., Yoshikawa, H., Yokoyama, Y., Tanabe, H., Nishino, K., Nomura, H., Kim, J. W., Kim, B. G., Pignata, S., Alexandre, J., Green, J., Isonishi, S., Terauchi, F., Fujiwara, K. and Aoki, D.

J Clin Oncol 34 ( 24 ) 2881 - 7 2016.08

Research paper (scientific journal), Joint Work, ISSN 0732-183X

PURPOSE: Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial that compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) in patients with CCC. PATIENTS AND METHODS: Six hundred sixty-seven patients with stage I to IV CCC of the ovary were randomly assigned to receive irinotecan 60 mg/m(2) on days 1, 8, and 15 plus cisplatin 60 mg/m(2) on day 1 (CPT-P group) every 4 weeks for six cycles or paclitaxel 175 mg/m(2) plus carboplatin area under the curve 6.0 mg/mL/min on day 1 every 3 weeks for six cycles (TC group). The primary end point was progression-free survival. Secondary end points were overall survival, overall response rate, and adverse events. RESULTS: Six hundred nineteen patients were clinically and pathologically eligible for evaluation. With a median follow-up of 44.3 months, 2-year progression-free survival rates were 73.0% in the CPT-P group and 77.6% in TC group (hazard ratio, 1.17; 95% CI, 0.87 to 1.58; P = .85). Two-year overall survival rates were 85.5% with CPT-P and 87.4% with TC (hazard ratio, 1.13; 95% CI, 0.80 to 1.61; one-sided P = .76). Grade 3/4 anorexia, diarrhea, nausea, vomiting, and febrile neutropenia occurred more frequently with CPT-P, whereas grade 3/4 leukopenia, neutropenia, thrombocytopenia, peripheral sensory neuropathy, and joint pain occurred more frequently with TC. CONCLUSION: No significant survival benefit was found for CPT-P. Both regimens were well tolerated, but the toxicity profiles differed significantly. Treatment with existing anticancer agents has limitations to improving the prognosis of CCC.

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癌とスタチン

AOKI DAISUKE

薬局 67 ( 9 ) 122 - 126 2016.08

Joint Work

遺伝性乳がん卵巣がん

AOKI DAISUKE

日本医師会雑誌 145 ( 4 ) 705 - 709 2016.07

Joint Work

Profiling of plasma metabolites in postmenopausal women with metabolic syndrome

Iida, M., Harada, S., Kurihara, A., Fukai, K., Kuwabara, K., Sugiyama, D., Takeuchi, A., Okamura, T., Akiyama, M., Nishiwaki, Y., Suzuki, A., Hirayama, A., Sugimoto, M., Soga, T., Tomita, M., Banno, K., Aoki, D. and Takebayashi, T.

Menopause 23 ( 7 ) 749 - 58 2016.07

Research paper (scientific journal), Joint Work, ISSN 1072-3714

OBJECTIVE: The aim of the study was to investigate the associations of amino acids and other polar metabolites with metabolic syndrome (MetS) in postmenopausal women in a lean Asian population. METHODS: The participants were 1,422 female residents enrolled in a cohort study from April to August 2012. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III modified for Japanese women. Associations were examined between MetS and 78 metabolites assayed in fasting plasma samples using capillary electrophoresis-mass spectrometry. Replication analysis was performed to confirm the robustness of the results in a separate population created by random allocation. RESULTS: Analysis was performed for 877 naturally postmenopausal women, including 594 in the original population and 283 in the replication population. The average age, body mass index, and levels of high- and low-density lipoprotein cholesterol of the entire population were 64.6 years, 23.0 kg/m, 72.1 mg/dL, and 126.1 mg/dL, respectively. There was no significant difference in low-density lipoprotein cholesterol levels between women with and without MetS. Thirteen metabolites were significantly related to MetS: multiple plasma amino acids were elevated in women with MetS, including branched-chain amino acids, alanine, glutamate, and proline; and alpha-aminoadipate, which is generated by lysine degradation, was also significantly increased. CONCLUSIONS: Our large-scale metabolomic profiling indicates that Japanese postmenopausal women with MetS have abnormal polar metabolites, suggesting altered catabolic pathways. These results may help to understand metabolic disturbance, including in persons with normal body mass index and relatively high levels of high-density lipoprotein cholesterol, and may have clinical utility based on further studies.

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子宮体部・卵巣同時発生重複癌40症例の臨床病理学的検討

AOKI DAISUKE

東京産科婦人科学会会誌 65 ( 3 ) 436 - 439 2016.07

Lynch症候群

AOKI DAISUKE

産婦人科の実際 65 ( 6 ) 709 - 715 2016.06

Joint Work

Optimal cytoreductive surgery in patients with advanced uterine carcinosarcoma: A multi-institutional retrospective study from the Japanese gynecologic oncology group

Harano, K., Hirakawa, A., Yunokawa, M., Nakamura, T., Satoh, T., Nishikawa, T., Aoki, D., Ito, K., Ito, K., Nakanishi, T., Susumu, N., Takehara, K., Watanabe, Y., Watari, H. and Saito, T.

Gynecol Oncol 141 ( 3 ) 447 - 453 2016.06

Research paper (scientific journal), Joint Work, ISSN 0090-8258

BACKGROUND: The benefits of cytoreductive surgery for uterine carcinosarcoma (UCS) are unknown. The objective of this study was to determine the impact of optimal surgery on advanced UCS patient survival. METHODS: We performed a multi-institutional, retrospective study of women diagnosed with stage IIIIV UCS between 2007 and 2012. Data were obtained retrospectively from medical records, including demographic, clinicopathologic, treatment, and outcome information. Optimal cytoreductive surgery was defined as surgery resulting in a maximum residual tumor of </=1cm. The Kaplan-Meier method was used to calculate progression-free survival (PFS) and overall survival (OS), and the Cox regression model was used to examine the impact of selected factors on survival. RESULTS: A total of 225 UCS patients (median age, 63years) were identified, including 136 (60%) with stage III and 89 (40%) with stage IV disease. Among these patients, 170 (76%) received optimal cytoreductive surgery. The median follow-up time was 19months. The median PFS was 11.5months (95% confidence interval [CI], 10.6-13.4) and 8.1months (95% CI, 5.1-9.5) for patients who received optimal and suboptimal cytoreductive surgery, respectively (P<0.0001). The median OS was 37.9months (95% CI, 28.3-not reached) and 18months (95% CI, 9.6-21) for patients who received optimal and suboptimal cytoreductive surgery, respectively (P<0.0001). Residual tumor >1cm was associated with worse OS while pelvic lymph node dissection was associated with improved OS. CONCLUSION: Optimal cytoreductive surgery and pelvic lymph node dissection are associated with improved OS in advanced UCS patients.

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遺伝性腫瘍

AOKI DAISUKE

産婦人科の実際 65 ( 6 ) 653 - 659 2016.06

Joint Work

改訂FIGO進行期分類の導入と患者登録

AOKI DAISUKE

臨床腫瘍プラクティス 12 ( 2 ) 125 - 132 2016.05

Joint Work

Organ Perfusion for Uterus Transplantation in Non-Human Primates With Assumed Procurement of a Uterus From a Brain-Dead Donor

Kisu, I., Kato, Y., Yamada, Y., Matsubara, K., Obara, H., Emoto, K., Adachi, M., Umene, K., Nogami, Y., Banno, K., Kitagawa, Y. and Aoki, D.

Transplant Proc 48 ( 4 ) 1266 - 9 2016.05

Research paper (scientific journal), Joint Work, ISSN 0041-1345

BACKGROUND: Clinical studies of uterus transplantation have been performed to treat uterine factor infertility. Because the uterus is a pelvic visceral organ, the method of perfusion for the procurement of vital organs from a brain-dead donor should be modified for removal of the uterus. Herein, we report the results of a preliminary study in cynomolgus monkeys of a new perfusion method for uterus transplantation with assumed procurement of a uterus from a brain-dead donor. METHODS: Cynomolgus monkeys were used; thoracolaparotomy was performed on the donor. A perfusion catheter was then placed into the unilateral femoral artery and/or external iliac artery. Cross-clamping was performed for the aorta under the diaphragm and the inferior vena cava was divided in the pleural space. The perfusion solution was then administered via the catheter to perfuse all organs in the abdominal cavity, including those in the pelvic cavity. After the perfusion, gross observation and histopathological examination of abdominal organs were conducted. RESULTS: Gross findings showed that all abdominal organs turned white in all specimens, indicating favorable perfusion of the uterus and all other organs in the abdomen. Pathological findings showed that almost no hemocytes were observed in the vessels of each organ. CONCLUSIONS: With perfusion via the femoral artery and/or external iliac artery, all organs in the abdominal cavity, including the uterus, could be perfused. It was suggested that this technique could be useful for uterus transplantation assuming the procurement of a uterus from a brain-dead donor.

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Anisakiasis mimics cancer recurrence: two cases of extragastrointestinal anisakiasis suspected to be recurrence of gynecological cancer on PET-CT and molecular biological investigation

Nogami, Y., Fujii-Nishimura, Y., Banno, K., Suzuki, A., Susumu, N., Hibi, T., Murakami, K., Yamada, T., Sugiyama, H., Morishima, Y. and Aoki, D.

BMC Med Imaging 16 31 2016.04

Research paper (scientific journal), Joint Work, ISSN 1471-2342

BACKGROUND: We report two cases of anisakiasis lesions that were initially suspected to be recurrence of gynecological cancer by positron emission tomography-computed tomography (PET-CT). Both cases were extragastrointestinal anisakiasis that is very rare. CASE PRESENTATION: The first case was a patient with endometrial cancer. At 19 months after surgery, a new low density area of 2 cm in diameter in liver segment 4 was found on follow-up CT. In PET-CT, the lesion had abnormal (18)fluoro-deoxyglucose (FDG) uptake with elevation in the delayed phase, with no other site showing FDG uptake. Partial liver resection was performed. A pathological examination revealed no evidence of malignancy, but showed necrotic granuloma with severe eosinophil infiltration and an irregular material with a lumen structure in the center. Parasitosis was suspected and consultation with the National Institute of Infectious Diseases (NIID) showed the larvae to be Anisakis simplex sensu stricto by genetic examination. The second case was a patient with low-grade endometrial stromal sarcoma (LG-ESS). At 8 months after surgery, swelling of the mediastinal lymph nodes was detected on CT and peripheral T-cell lymphoma was diagnosed by biopsy. A new peritoneal lesion with abnormal FDG uptake was detected on pre-treatment PET-CT and this lesion was increased in size on post-treatment PET-CT. Tumorectomy was performed based on suspected dissemination of LG-ESS recurrence. The findings in a pathological examination were similar to the first case and we again consulted the NIID. The larvae was identified as Anisakis pegreffi, which is a rare pathogen in humans. Having experienced these rare cases, we investigated the mechanisms of FDG uptake in parasitosis lesions by immunohistochemical staining using antibodies to glucose transporter type 1 (GLUT-1) and hexokinase type 2 (HK-2). While infiltrated eosinophils were negative, macrophages demonstrated positive for both antibodies. Therefore, mechanisms behind FDG uptake may involve macrophages, which is common among various granulomas. This is the first report to investigate parasitosis in such a way. CONCLUSION: These cases suggest that anisakiasis is a potential differential diagnosis for a lesion with FDG uptake in PET-CT, and that it is difficult to distinguish this disease from a recurrent tumor using PET-CT alone.

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子宮頸がんに対する妊孕性温存手術の適応と注意点

AOKI DAISUKE

臨床婦人科産科（知りたい最新情報がすぐわかる！　不妊・不育症診療パーフェクトガイド）増刊号70 ( 4 ) 15 - 19 2016.04

Joint Work

Neoadjuvant chemotherapy for locally advanced cervical cancer

Iwata, T., Miyauchi, A., Suga, Y., Nishio, H., Nakamura, M., Ohno, A., Hirao, N., Morisada, T., Tanaka, K., Ueyama, H., Watari, H. and Aoki, D.

Chin J Cancer Res 28 ( 2 ) 235 - 40 2016.04

Research paper (scientific journal), Joint Work, ISSN 1000-9604

Neoadjuvant chemotherapy followed by surgery (NCS) has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy (NAC) used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials (RCTs) have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy (CCRT) has markedly improved the outcome of radiotherapy (RT), and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT.

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子宮移植の現状と課題

AOKI DAISUKE

Pharma Medica 34 ( 4 ) 39 - 45 2016.04

Joint Work

メソトレキセート治療後の頸管妊娠に対し子宮鏡下切除した1例

遠藤豊英，吉政佑之，升田博隆，片倉慧美，日原華子，三木史恵，内田明花，内田浩，丸山哲夫，田中守，青木大輔

東京産科婦人科学会会誌 65 ( 2 ) 344 - 349 2016.04

Research paper (scientific journal), Joint Work

妊娠を契機に発見された浸潤子宮頸癌症例の検討

AOKI DAISUKE

関東連合産科婦人科学会誌 53 ( 1 ) 139 - 145 2016.03

Joint Work

The importance of para-aortic lymph nodes in sentinel lymph node mapping for endometrial cancer by using hysteroscopic radio-isotope tracer injection combined with subserosal dye injection: Prospective study

Kataoka, F., Susumu, N., Yamagami, W., Kuwahata, M., Takigawa, A., Nomura, H., Takeuchi, H., Nakahara, T., Kameyama, K. and Aoki, D.

Gynecol Oncol 140 ( 3 ) 400 - 4 2016.03

Research paper (scientific journal), Joint Work, ISSN 0090-8258

OBJECTIVE: The objective of this study is to evaluate the detection rate and diagnostic accuracy of sentinel lymph node (SN) mapping using hysteroscopic sub-endometrial injection of 99m-Technetium labeled phytate (Radio-isotope; RI method) and subserosal Indocyanine green (ICG) injection (Dye method) in patients with endometrial cancer. METHODS: From April 2009 to December 2012, prospective evaluation of 57 Japanese endometrial cancer patients undergoing SN mapping using RI method combined with Dye method was done. To combine RI method or no was determined by a status of RI supply of the tracer injection day. As for 32 cases, both (RI+Dye) methods were used and 23 cases were performed only in Dye method. The primary endpoint was estimation of sensitivity and negative predictive value (NPV) of SN, and analysis of the distribution of SNs with metastasis. RESULTS: At least one SN was detected in 100% and average number of detected SNs was 6.0 in RI+Dye method. Sensitivity and NPV were 100%, 100%, respectively. From results of SN mapping, 62.8% of SNs were present in pelvic and 37.1% in para-aortic lymph nodes (PAN). Total 56.3% of lymph nodes with metastasis were present in pelvic and 43.8% in PAN, and the distribution has no difference with SN mapping results (P=0.602). Among 13 cases with metastatic SNs, 76.9% cases showed metastasis in PAN. CONCLUSIONS: This SN mapping procedure for endometrial cancer patients revealed high detection rate, sensitivity, NPV, and also indicated the importance of the SN exploration in PAN area.

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A prospective observational study on chemotherapy-induced nausea and vomiting (CINV) in patients with gynecologic cancer by the CINV Study Group of Japan

Mizuno, M., Hiura, M., Kikkawa, F., Numa, F., Yaegashi, N., Narahara, H., Aoki, D., Kimura, E., Kato, H., Shimokawa, M., Sugiyama, T. and Kamura, T.

Gynecol Oncol 140 ( 3 ) 559 - 64 2016.03

Research paper (scientific journal), Joint Work, ISSN 0090-8258

OBJECTIVE: This study was performed to investigate the occurrence of and risk factors for chemotherapy-induced nausea and vomiting (CINV) in patients with gynecologic cancer. METHODS: In total, 214 patients with gynecologic cancer who underwent highly emetogenic (HEC) or moderately emetogenic chemotherapy (MEC) were evaluated. We investigated the relationship between CINV and clinical factors and the accuracy of estimation of CINV by medical staff in the acute and late phases. Vomiting was evaluated in terms of frequency, and nausea was evaluated with a 100-mm visual analog scale on days 1 to 7. We also analyzed the risk factors and changes in CINV over time using a generalized linear mixed (GLM) model. RESULTS: The multivariate analysis revealed no significant risk factors for acute CINV. The independent risk factors for delayed nausea were a morning sickness history (odds ratio [OR], 2.687; 95% confidence interval [95% CI], 1.450-4.976; p=0.0017), age (each 1-year increment) (OR, 0.97; 95% CI, 0.944-0.996; p=0.0235), and HEC (OR, 2.134; 95% CI, 1.039-4.383; p=0.0391). The GLM model demonstrated that the independent factors affecting nausea were significant morning sickness (p=0.0101) and HEC (p=0.0136). These data also showed more severe nausea from days 3 to 5, but the negative predictive value for estimation of delayed nausea by medical staff was 57.8%. CONCLUSION: Our data suggest that improvement of preventive antiemetic administration is needed for patients with risk factors to manage delayed CINV caused by HEC and by MEC.

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卵巣腫瘍・卵管癌・腹膜癌取扱い規約　臨床編

AOKI DAISUKE

日本産科婦人科学会雑誌 68 ( 3 ) 1097 - 1116 2016.03

Joint Work

分子標的治療薬の婦人科領域への展開

AOKI DAISUKE

産科と婦人科 83 ( 6 ) 642 - 653 2016.03

Joint Work

子宮内膜増殖症（異形増殖症を含む）

AOKI DAISUKE

産科と婦人科（産婦人科処方実践マニュアル） 83 ( Suppl. ) 128 - 130 2016.03

Joint Work

子宮体癌（進行・再発/高リスク）

AOKI DAISUKE

産科と婦人科（産婦人科処方実践マニュアル） 83 ( Suppl. ) 135 - 138 2016.03

Joint Work

遺伝性乳がん卵巣がんに対するリスク低減卵管卵巣摘出術と術後ヘルスケア

AOKI DAISUKE

更年期と加齢のヘルスケア 14 ( 2 ) 316 - 318 2016.02

Joint Work

Prognostic factors in patients with uterine carcinosarcoma: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group

Harano, K., Hirakawa, A., Yunokawa, M., Nakamura, T., Satoh, T., Nishikawa, T., Aoki, D., Ito, K., Ito, K., Nakanishi, T., Susumu, N., Takehara, K., Watanabe, Y., Watari, H. and Saito, T.

Int J Clin Oncol 21 ( 1 ) 168 - 76 2016.02

Research paper (scientific journal), Joint Work, ISSN 1341-9625

BACKGROUND: Uterine carcinosarcomas (UCSs) are rare and aggressive tumors. The prognostic factors are not sufficiently known. METHODS: We performed a multi-institutional, retrospective study of women with stage I-IV UCS, diagnosed between 2007 and 2012. Data obtained from medical records included demographic, clinicopathological, treatment, and outcome information. RESULTS: A total of 486 patients (median age 65 years) were identified-224 (46 %) were stage I, 32 (7 %) were stage II, 139 (28 %) were stage III, and 91 (19 %) were stage IV. Among them, 277 (57 %) had disease recurrence. Median disease-free survival (DFS) was 16.4 months [95 % confidence interval (CI) 15.7-27.2], and median overall survival (OS) was 72.0 months (95 % CI 43.0-not reached). In total, 454 (94 %) patients received adjuvant treatment, and 440 (91 %) received adjuvant chemotherapy. In multivariate analysis, stage III-IV disease, CA-125 level, and lymphovascular space invasion (LVSI) were significantly associated with shorter median DFS. Stage III-IV disease, performance status 2-4, >/=50 % myometrial invasion depth, and postsurgical residual tumor size >1 cm were significantly associated with shorter median OS. Conversely, pelvic lymph node lymphadenectomy was associated with improved DFS and OS. CONCLUSIONS: Stage, performance status, CA-125 level, LVSI, and myometrial invasion were associated with poor prognoses. Pelvic lymphadenectomy was associated with improved survival, and may be necessary for the surgical management of UCS.

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Metformin: A candidate for the treatment of gynecological tumors based on drug repositioning

Irie, H., Banno, K., Yanokura, M., Iida, M., Adachi, M., Nakamura, K., Umene, K., Nogami, Y., Masuda, K., Kobayashi, Y., Tominaga, E. and Aoki, D.

Oncol Lett 11 ( 2 ) 1287 - 1293 2016.02

Joint Work, ISSN 1792-1074

Metformin is a first-line drug used for the treatment of type 2 diabetes. Recently, metformin has been reported to reduce the carcinogenic risk and inhibit tumor cell growth in glioma and breast cancer. The anticancer action of metformin involves the enhancement of phosphorylation of liver kinase B1, activation of adenosine monophosphate-activated protein kinase and inhibition of mammalian target of rapamycin, which reduces cell growth. Metformin is anticipated to exert antitumor effects in gynecological cancer, and its efficacy for the treatment of endometrial, breast and ovarian cancer has been suggested in preclinical studies and clinical trials. Although the effect of metformin on cervical cancer remains to be examined in clinical trials, its antitumor effects have been reported in preclinical studies. Thus, the use of metformin for the treatment of gynecological cancer may become a successful example of drug repositioning, following establishment of the drug's antitumor effects, risk evaluation, screening and validation of efficacy.

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Intravenous low-grade endometrial stromal sarcoma with intracardiac extension: A CASE OF inaccurate tumor location on contrast-enhanced computed tomography

Nogami, Y., Yamagami, W., Maki, J., Banno, K., Susumu, N., Tomita, K., Matsubara, K., Obara, H., Kitagawa, Y. and Aoki, D.

Mol Clin Oncol 4 ( 2 ) 179 - 182 2016.02

Research paper (scientific journal), Joint Work, ISSN 2049-9450

We herein report a case of low-grade endometrial stromal sarcoma with intracardiac extension in a 58-year-old woman with a uterine tumor with intravascular involvement. The tumor was suspected preoperatively to be an endometrial stromal sarcoma by magnetic resonance imaging. The extent of intravascular involvement was determined to be below the level of the renal veins on preoperative contrast-enhanced computed tomography (CT). However, perioperative echography revealed that the tumor extended to the right atrium. An emergency cardiotomy with extracorporeal circulation was required. The risk of tumor embolism was reduced through transection of the inferior vena cava, but the tumor was difficult to remove completely. Postoperative hormonal therapy reduced the size of the residual tumor and no recurrence was detected for 1 year. The preoperative contrast-enhanced CT was unable to detect the free-floating intravascular tumor. This case illustrates a limitation of CT and indicates that accurate determination of the tumor extent for planning a surgical strategy in similar cases should be performed using multiple imaging methods.

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ARID1A gene mutation in ovarian and endometrial cancers (Review)

Takeda, T., Banno, K., Okawa, R., Yanokura, M., Iijima, M., Irie-Kunitomi, H., Nakamura, K., Iida, M., Adachi, M., Umene, K., Nogami, Y., Masuda, K., Kobayashi, Y., Tominaga, E. and Aoki, D.

Oncol Rep 35 ( 2 ) 607 - 13 2016.02

Research paper (scientific journal), Joint Work, ISSN 1021-335X

The AT-rich interacting domaincontaining protein 1A gene (ARID1A) encodes ARID1A, a member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces changes in expression of multiple genes (CDKN1A, SMAD3, MLH1 and PIK3IP1) via chromatin remodeling dysfunction, contributes to carcinogenesis, and has been shown to cause transformation of cells in association with the PI3K/AKT pathway. Information on ARID1A has emerged from comprehensive genomewide analyses with nextgeneration sequencers. ARID1A mutations have been found in various types of cancer and occur at high frequency in endometriosisassociated ovarian cancer, including clear cell adenocarcinoma and endometrioid adenocarcinoma, and also occur at endometrial cancer especially in endometrioid adenocarcinoma. It has also been suggested that ARID1A mutation occurs at the early stage of canceration from endometriosis to endometriosisassociated carcinoma in ovarian cancer and also from atypical endometrial hyperplasia to endometrioid adenocarcinoma in endometrial cancer. Therefore, development of a screening method that can detect mutations of ARID1A and activation of the PI3K/AKT pathway might enable early diagnosis of endometriosisassociated ovarian cancers and endometrial cancers. Important results may also emerge from a current clinical trial examining a multidrug regimen of temsirolimus, a small molecule inhibitor of the PI3K/AKT pathway, for treatment of advanced ovarian clear cell adenocarcinoma with ARID1A mutation and PI3K/AKT pathway activation. Also administration of sorafenib, a multikinase inhibitor, can inhibit cancer proliferation with PIK3CA mutation and resistance to mTOR inhibitors and GSK126, a moleculartargeted drug can inhibit proliferation of ARID1Amutated ovarian clear cell adenocarcinoma cells by targeting and inhibiting EZH2. Further studies are needed to determine the mechanism of chromatin remodeling dysregulation initiated by ARID1A mutation, to develop methods for early diagnosis, to investigate new cancer therapy targeting ARID1A, and to examine the involvement of ARID1A mutations in development, survival and progression of cancer cells.

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Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia

Inoue, O., Hamatani, T., Susumu, N., Yamagami, W., Ogawa, S., Takemoto, T., Hirasawa, A., Banno, K., Kuji, N., Tanaka, M. and Aoki, D.

Reprod Biol Endocrinol 14 2 2016.01

Research paper (scientific journal), Joint Work, ISSN 1477-7827

BACKGROUND: Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilation and curettage (D&C) and endometrial biopsy (EMB), which could result in endometritis, endometrial thinning, or intrauterine adhesion. In turn, any of these outcomes could adversely affect implantation and pregnancy development. The current study thus aimed to identify factors that might affect pregnancy following conservative treatment by MPA. METHODS: We compared a pregnancy group (45 patients) with a non-pregnancy group (53 patients) of MPA-treated patients to evaluate the factors affecting clinical pregnancy establishment. We undertook a multivariate logistic regression analysis based on factors shown by univariate analysis to be significantly different between the groups. Univariate analysis identified number of D&C, endometrial thickness, duration of MPA administration, age of pregnancy permission (the age at which a patient was first allowed to attempt pregnancy after disappearance of the lesion), period of disappearance of lesions, and recurrence as independent variables. RESULTS: The odds ratios (95 % confidence interval) of multivariate analysis for disease recurrence, endometrial thickness during ovulation, and age of pregnancy permission were 0.283 (0.102-0.785), 1.677 (1.251-2.248), and 0.889 (0.792-0.998), respectively. There was no significant difference in the other independent variables between groups. CONCLUSIONS: We identified three factors considered to affect pregnancy establishment following conservative treatment with MPA: recurrence, endometrial thickness during ovulation, and the age of the pregnancy permission. Introduction of infertility treatment including assisted reproductive technology (ART) soon after achieving tumor disappearance by MPA would therefore be beneficial for patients with disease recurrence, thin endometrium, or a higher age of pregnancy permission.

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バイオリソースを用いた研究基盤整備に関する国内外の動き

AOKI DAISUKE

産科と婦人科 83 ( 1 ) 13 - 19 2016.01

Joint Work

Pregnancy Outcomes After Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer: A 13-Year Experience in a Single Tertiary-Care Center

Kasuga, Y., Nishio, H., Miyakoshi, K., Sato, S., Sugiyama, J., Matsumoto, T., Tanaka, K., Ochiai, D., Minegishi, K., Hamatani, T., Iwata, T., Morisada, T., Nakamura, M., Fujii, T., Kuji, N., Aoki, D. and Tanaka, M.

Int J Gynecol Cancer 26 ( 1 ) 163 - 8 2016.01

Research paper (scientific journal), Joint Work, ISSN 1048-891X

OBJECTIVE: To investigate pregnancy outcomes in women after abdominal radical trachelectomy (RT) for early-stage cervical cancer. METHODS: The patients' background, fertility, and pregnancy outcomes were reviewed in a total of 61 pregnancies in 48 of 172 women who underwent abdominal RT at Keio University Hospital between September 2002 and December 2013. RESULTS: There were 5 women with stage IA1, 2 with stage IA2, and 41 with stage IB1. Histological types were as follows: squamous cell carcinoma (n = 36), adenocarcinoma (n = 10), and adenosquamous cell carcinoma (n = 2). The pregnancy rate of women attempting to conceive after abdominal RT was 44% (48/109). The mean +/- SD duration from abdominal RT to conception was 3.1 +/- 1.9 years. Of 61 pregnancies, 42 pregnancies were achieved by fertility treatment (in vitro fertilization-embryo transfer, 39; intrauterine insemination, 3). After excluding one pregnancy without detailed clinical information, there were 42 live births (5 in 22-27 weeks, 11 in 28-33weeks, 20 in 34-36 weeks, and 6 in 37-38 weeks), 13 miscarriages, and 5 ongoing pregnancies. While there were 10 first trimester miscarriages, 3 pregnancies ended in the second trimester owing to chorioamnionitis. The mean gestational age at birth was 33 weeks of pregnancy. Thirty-seven neonates were appropriate-for-date, and one was small-for-date. Six pregnancies exhibited massive bleeding from the residual cervix in the late pregnancy. Preterm birth less than 34 weeks of pregnancy was related to premature rupture of the membrane (P < 0.05). Chorioamnionitis was evident in 9 of 11 pregnancies with preterm premature rupture of the membrane followed by birth at less than 34 weeks of pregnancy. No parturients exhibited lochiometra and endometritis postpartum. CONCLUSIONS: Abdominal RT provided favorable pregnancy outcomes, and fertility treatment could be advantageous to conception. Massive bleeding from the residual cervix as well as ascending infection might be characteristic features during pregnancy after abdominal RT.

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Expression of potential biomarkers associated with homologous recombination repair in patients with ovarian or triple-negative breast cancer

Nomura, H., Kataoka, F., Aoki, D., Jinno, H., Kitagawa, Y., Sato, Y., Womack, C., Wombwell, H., Hodgson, D., O'Connor, M., Harbron, C. and Yin, X.

Cancer Biomark 16 ( 1 ) 145 - 52 2016

Research paper (scientific journal), Joint Work, ISSN 1574-0153

BACKGROUND: Poly(ADP)-ribose polymerase (PARP) inhibitors such as olaparib can induce cell death in cancer cells with homologous recombination (HR) DNA repair deficiencies, such as BRCA1/2 mutations. AIM: To identify prognostic biomarkers of long-term outcomes in cancer patients. METHODS: Immunohistochemistry was used to analyse expression of key HR pathway proteins (ATM, ATR, BRCA1, MDC1, MRE11) and PARP-1 in 100 serous ovarian cancer (SOC) and 100 triple-negative breast cancer (TNBC) tumour samples from Japanese patients. RECIST assessment was used. RESULTS: Patient demographic data and BRCA1/2 mutation status were unavailable. Most proteins listed previously were detected in > 80% of tissue samples, with BRCA1 expression detected in 60-65%. A potential link between BRCA1 expression and overall survival (M stage adjusted) in SOC patients was observed, but was not statistically significant after multiple testing adjustment. Correlations between other biomarker expression and survival were not observed. In TNBC patients, MDC1 staining was associated with progressive disease, but this was not statistically significant; the analysis did not identify significant correlations between biomarker expression and disease control. Limited event numbers prevented assessment of the prognostic value of BRCA1 in TNBC. CONCLUSION: BRCA1 expression may be a candidate for a prognostic biomarker in SOC. Further studies are warranted.

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Survey of Attitudes toward Uterus Transplantation among Japanese Women of Reproductive Age: A Cross-Sectional Study

Kisu, I., Banno, K., Soeda, E., Kurihara, Y., Okushima, M., Yamaguchi, A., Nakagawa, E., Umene, K. and Aoki, D.

PLoS One 11 ( 5 ) e0156179 2016

Research paper (scientific journal), Joint Work, ISSN 1932-6203

OBJECTIVE: Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child, but there has been no large-scale survey of the views on UTx in women of reproductive age in Japan. The present study was aimed to clarify the views of Japanese women of reproductive age on UTx for uterine factor infertility. METHODS: A questionnaire on UTx was conducted by an Internet research company in December 2014 as a cross-sectional study in 3,892 randomly chosen women aged 25 to 39 years old. Responses were analyzed from 3,098 subjects (mean age 32.1+/-4.2 years old), after exclusion of inappropriate respondents in screening. RESULTS: Of the respondents, 62.1%, 34.7% and 18.1% favored adoption, UTx and gestational surrogacy, respectively. In contrast, 7.0%, 21.9% and 63.3% opposed adoption, UTx and gestational surrogacy, respectively. In choices of candidates for UTx based on highest priority, deceased persons (33.8%) and mothers (19.0%) were favored as donors, and women with congenital absence of the uterus (54.4%) and hysterectomy due to a malignant uterine tumor (20.0%) as recipients. Regarding societal acceptance of UTx, the answer rates were 15.7% for "UTx should be permitted", 77.6% for "UTx should be permitted with discussion", and 6.7% for "UTx should not be permitted, even with discussion". Regarding personal opinions on UTx, 44.2% were in favor, 47.5% had no opinion, and 8.3% were against. CONCLUSION: Our results suggest that many Japanese women of reproductive age feel that UTx is socially and individually acceptable, but that concerns requiring further discussion remain among these women. There was also a tendency for UTx to be viewed more favorably than gestational surrogacy.

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Characterization of the STK11 splicing variant as a normal splicing isomer in a patient with Peutz-Jeghers syndrome harboring genomic deletion of the STK11 gene

Masuda, K., Kobayashi, Y., Kimura, T., Umene, K., Misu, K., Nomura, H., Hirasawa, A., Banno, K., Kosaki, K., Aoki, D. and Sugano, K.

Hum Genome Var 3 16002 2016

Research paper (scientific journal), Joint Work, ISSN 2054-345X

We report a STK11 splicing variant comprising a 131-bp insertion that is derived from intron 1, which has previously been reported to possess potent pathogenicity. The same variant was detected in a Peutz-Jeghers syndrome patient harboring a genomic deletion in the vicinity of exon 1 of the STK11 gene, which indicated that this variant was derived from the wild-type allele. We also found the same variant in other normal subjects. This variant corresponds to the predicted transcript variant of STK11 (XM_011528209), which is derived from the genomic sequence of Chr19 (NT_011295.12). Therefore, we concluded that the splicing variant was not pathogenic.

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Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology

Yamagami, W. and Aoki, D.

J Obstet Gynaecol Res 41 ( 12 ) 1861 - 9 2015.12

Joint Work, ISSN 1341-8076

The Japan Society of Obstetrics and Gynecology collects and analyzes annual data on gynecologic cancers from member institutions. Here we present the Treatment Annual Report for 2007. Data on the prognosis of 3381 patients with cervical cancer, 3681 with endometrial cancer, and 2367 with ovarian cancer for whom treatment was initiated in 2007 were analyzed in the Treatment Annual Report. In the 2007 Treatment Annual Report, stage I accounted for 53.1%, stage II for 24.4%, stage III for 14.2%, and stage IV for 8.3% of all patients with cervical cancer. Stage I accounted for 64.8%, stage II for 8.2%, stage III for 20.2%, and stage IV for 6.9% of all patients with endometrial cancer. Stage I accounted for 41.4%, stage II for 9.9%, stage III for 30.6%, and stage IV for 8.6% of all patients with ovarian cancer. The 5-year overall survival rates for patients with cervical cancer were 91.8% for stage I, 71.5% for stage II, 53.0% for stage III, and 23.7% for stage IV; those for patients with endometrial cancer were 95.3%, 89.8%, 75.6%, and 29.1%, and those for patients with ovarian surface epithelial-stromal tumors were 91.5%, 76.1%, 46.9%, and 31.3%, respectively.

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Human Papillomavirus Test for Triage of Japanese Women With Low-Grade Squamous Intraepithelial Lesions

Iwata, T., Hasegawa, T., Ochiai, K., Takizawa, K., Umezawa, S., Kuramoto, H., Ohmura, M., Kubushiro, K., Arai, H., Sakamoto, M., Motoyama, T., Watanabe, K. and Aoki, D.

Reprod Sci 22 ( 12 ) 1509 - 15 2015.12

ISSN 1933-7191

We evaluated high-risk human papillomavirus (HR-HPV) DNA testing for high-grade cervical intraepithelial neoplasia (CIN) lesions by cobas HPV test and diagnostic HPV16/18 genotyping in Japanese women with low-grade squamous intraepithelial lesions. Of 357 patients, HR-HPV positivity prevalence was 75.6%, and 21.3% had grade 2 or higher CIN lesions (CIN2+), with the highest prevalence at 30 to 34 years. Negative predictive values of HR-HPV for CIN2+ in our patients were 93.1% (any age) and 94.9% (40-50 years). Absolute risk for CIN2+ in HR-HPV positive and HPV16/18 positive individuals was 25.9 and 35.1, respectively. Relative risk for CIN2+ lesions was 5.1 for HPV16/18 positive versus HR-HPV negative, and 3.8 for HR-HPV positive versus HR-HPV negative women. Predictive values of CIN2+ positive were higher for HPV16/18 positive women (any age) than 12 other HPV positive-genotypes, and highest (50%) at 40-50 years. The HPV16/18 genotyping might prevent women (>40 years) at risk of high-grade CIN lesions from undergoing unnecessary colposcopy/overtreatment of nonprogressive lesions.

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Prognostic importance of CDK4/6-specific activity as a predictive marker for recurrence in patients with endometrial cancer, with or without adjuvant chemotherapy

Ikeda, Y., Oda, K., Ishihara, H., Wada-Hiraike, O., Miyasaka, A., Kashiyama, T., Inaba, K., Fukuda, T., Sone, K., Matsumoto, Y., Arimoto, T., Maeda, D., Ikemura, M., Fukayama, M., Kawana, K., Yano, T., Aoki, D., Osuga, Y. and Fujii, T.

Br J Cancer 113 ( 10 ) 1477 - 83 2015.11

Joint Work, ISSN 0007-0920

BACKGROUND: Pathologically low-risk endometrial cancer patients do not receive postoperative treatment; however, 10-15% of these patients show recurrence with poor prognosis. We evaluated the clinical importance of cyclin-dependent kinase 4/6 (CDK4/6) activity, and its significance as a novel biomarker for the prognosis and chemo-sensitivity of endometrioid endometrial carcinoma (EEC). METHODS: Cyclin-dependent kinase 4/6 expression and enzyme activity in 109 tumour samples from patients with EEC were examined with a cell-cycle profiling (C2P) assay. CDK4/6-specific activity (CDK4/6SA) was determined, and its relationship with clinicopathological factors and expression of Ki-67 was analysed. RESULTS: CDK4/6-specific activity was significantly correlated with Ki-67 (P=0.035), but not with any other clinicopathological characteristics. CDK4/6SA was significantly higher (P=0.002) in pathologically low-risk patients (not receiving adjuvant chemotherapy, n=74) than in intermediate- or high-risk patients (receiving adjuvant chemotherapy, n=35). In addition, patients with high CDK4/6SA (>3.0) showed significantly (P=0.024) shorter progression-free survival (PFS) than those with low CDK4/6SA (<3.0). Although Ki-67 expression itself was not a marker for prognosis, the combination of high CDK4/6SA and high Ki-67 expression (>15%) was robustly associated with shorter PFS (P=0.015), and this combination was an independent poor prognostic factor in the low-risk group. Inversely, in the intermediate-/high-risk group, patients with high CDK4/6SA had a tendency of a more favourable prognosis compared with patients with low CDK4/6SA (P=0.063). CONCLUSIONS: CDK4/6-specific activity can be used as a biomarker to predict prognosis and, possibly, chemo-sensitivity. The combination of Ki-67 expression might strengthen the clinical usefulness of CDK4/6SA as a biomarker.

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腹腔鏡下手術が契機となり診断確定に至った卵管癌2症例の経験

AOKI DAISUKE

関東連合産科婦人科学会誌 52 ( 4 ) 811 - 817 2015.11

解剖に基づいた腹腔鏡手術のトレーニング

AOKI DAISUKE

産科と婦人科 82 ( 11 ) 1284 - 1289 2015.11

Joint Work

妊娠初期における脳瘤の検出を契機にMeckel-Gruber症候群と胎内診断した1例

AOKI DAISUKE

東京産科婦人科学会会誌 64 ( 4 ) 591 - 595 2015.10

Joint Work

Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment

Kiba, A., Banno, K., Yanokura, M., Asada, M., Nakayama, Y., Aoki, D. and Watanabe, T.

J Obstet Gynaecol Res 41 ( 10 ) 1598 - 606 2015.10

ISSN 1447-0756

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脂質異常症治療薬スタチンが抗悪性腫瘍薬となる未来

AOKI DAISUKE

産科と婦人科 82 ( 10 ) 1125 - 1129 2015.10

Joint Work

How do Japanese gynecologists view hormone replacement therapy for survivors of endometrial cancer? Japanese Gynecologic Oncology Group (JGOG) survey

Yokoyama, Y., Ito, K., Takamatsu, K., Takehara, K., Nakanishi, T., Harano, K., Watari, H., Susumu, N., Aoki, D. and Saito, T.

Int J Clin Oncol 20 ( 5 ) 997 - 1004 2015.10

ISSN 1341-9625

BACKGROUND: This survey sought to determine Japanese gynecologists' attitudes concerning administering hormone replacement therapy (HRT) for patients after surgery for endometrial cancer (EC). METHODS: Eight hundred and eighty-eight members of the Japanese Gynecologic Oncology Group (JGOG) were asked to respond to an anonymous questionnaire on the JGOG website. The survey asked whether or not HRT was to be administered when surgery was performed (including a hysterectomy and bilateral oophorectomy) to treat EC before or after menopause. If HRT was not to be administered, respondents were asked the reason why. Respondents were presented with the same hypothetical patients that were featured in a previous survey in Germany, and differences in the mindsets of Japanese and German physicians were compared. RESULTS: Responses from 363 individuals (response rate 40.9 %) were analyzed. Seventy-eight percent of physicians considered HRT for patients undergoing surgery before menopause. The most prevalent reason of refusal to prescribe HRT was the risk of EC recurrence. Forty-eight percent of physicians considered HRT for patients undergoing surgery after menopause. The most prevalent reasons of refusal of HRT were its limited benefit and the availability of alternative therapies. Sixty-five percent of Japanese physicians responded that they would administer HRT to patients with low risk of recurrence vs. 46 % of physicians in Germany (P < 0.0002). Forty-nine percent of Japanese physicians approved of prescribing HRT for patients with high risk of recurrence vs. 25 % of physicians in Germany (P < 0.0001). CONCLUSION: Many Japanese gynecologists have a favorable attitude toward prescribing HRT after treatment of EC.

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術後感染症リンパ嚢胞の治療方法に関する検討

AOKI DAISUKE

東京産科婦人科学会会誌 64 ( 4 ) 571 - 575 2015.10

Joint Work

子宮体がんの予防とヘルスケア

AOKI DAISUKE

産婦人科の実際　女性ヘルスケア　集中講義！ 61 ( 10月臨時増刊号 ) 399 - 408 2015.10

Joint Work

Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women

Yokota, M., Hirasawa, A., Makita, K., Akahane, T., Sakai, K., Makabe, T., Horiba, Y., Yamagami, W., Ogawa, M., Iwata, T., Yanamoto, S., Deshimaru, R., Banno, K., Susumu, N. and Aoki, D.

Prz Menopauzalny 14 ( 3 ) 161 - 7 2015.09

ISSN 1643-8876

INTRODUCTION: Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO is not well understood. To improve the quality of life for post-BSO patients, it is important to determine the genetic factors that influence their risk for osteoporosis. The aim of this study was to investigate the association between gene variations of estrogen metabolism-related genes and osteoporosis in surgically menopausal patients, which may improve their quality of life. MATERIAL AND METHODS: This study included 203 menopausal women treated with BSO because of gynecologic disorders. One hundred and twenty-six women with artificial (surgical) menopause, who had undergone BSO in the premenopausal period, were compared with 77 women with natural menopause, who had undergone BSO in the postmenopausal period. The women were tested for bone mineral density to diagnose osteoporosis. Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated. RESULTS: No significant association was found between osteoporosis and polymorphisms in ESR1, UGT2B17, or UGT1A1 in both groups, suggesting that BSO might be a more significant physiological factor in influencing bone mass density compared to genetic variations. CONCLUSIONS: These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women.

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High Expression of p62 Protein Is Associated with Poor Prognosis and Aggressive Phenotypes in Endometrial Cancer

Iwadate, R., Inoue, J., Tsuda, H., Takano, M., Furuya, K., Hirasawa, A., Aoki, D. and Inazawa, J.

Am J Pathol 185 ( 9 ) 2523 - 33 2015.09

ISSN 1525-2191

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A surgical technique using the ovarian vein in non-human primate models of potential living-donor surgery of uterus transplantation

Kisu, I., Banno, K., Mihara, M., Hara, H., Umene, K., Adachi, M., Nogami, Y. and Aoki, D.

Acta Obstet Gynecol Scand 94 ( 9 ) 942 - 8 2015.09

ISSN 1600-0412

Prevalence and differentiation of hereditary breast and ovarian cancers in Japan

Nakamura, S., Takahashi, M., Tozaki, M., Nakayama, T., Nomizu, T., Miki, Y., Murakami, Y., Aoki, D., Iwase, T., Nishimura, S., Yamauchi, H., Ohsumi, S., Baba, S. and Shimizu, T.

Breast Cancer 22 ( 5 ) 462 - 8 2015.09

Joint Work, ISSN 1880-4233

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Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer

Suemori, T., Susumu, N., Iwata, T., Banno, K., Yamagami, W., Hirasawa, A., Sugano, K., Matsumoto, E. and Aoki, D.

Int J Gynecol Cancer 25 ( 7 ) 1165 - 72 2015.09

ISSN 1525-1438

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ⅠB1期への広汎性子宮頸部摘出術

AOKI DAISUKE

臨床婦人科産科 69 ( 9 ) 826 - 830 2015.09

Joint Work

遺伝性乳癌・卵巣癌

AOKI DAISUKE

臨床画像 31 ( 10 増刊号 ) 220 - 221 2015.09

Joint Work

東京都の子宮頸がん検診の精度管理について

AOKI DAISUKE

東京都医師会雑誌 68 ( 8 ) 15 - 18 2015.09

Single Work

家族性腫瘍としての子宮内膜癌

AOKI DAISUKE

日本臨床　家族性腫瘍学－家族性腫瘍の最新研究動向－ 73 ( 増刊号6 ) 467 - 470 2015.08

Joint Work

子宮頸癌に対する同時化学放射線療法後に生じた晩期有害事象の検討

AOKI DAISUKE

東京産科婦人科学会会誌 64 ( 3 ) 349 - 353 2015.07

Joint Work

Absence of lactobacilli containing glycolipids with the alpha-galactose epitope and the enhanced fucosylation of a receptor glycolipid GA1 in the digestive tracts of immune-deficient scid mice

Iwamori, M., Tanaka, K., Adachi, S., Aoki, D. and Nomura, T.

J Biochem 158 ( 1 ) 73 - 82 2015.07

ISSN 1756-2651

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BRCA1/2遺伝子変死保持者に対するリスク低減卵管卵巣摘出術とサーベイランス

AOKI DAISUKE

産科と婦人科 82 ( 6 ) 639 - 642 2015.06

Joint Work

Effects of chemotherapy on patients with recurrent cervical cancer previously treated with concurrent chemoradiotherapy: a retrospective multicenter survey in Japan

Tokunaga H, Nakanishi T, Iwata T, Aoki D, Saito T, Nagase S, Takahashi F, Yaegashi N, Watanabe Y

Int J Clin Oncol 20 ( 3 ) 561 - 565 2015.06

Research paper (scientific journal), Joint Work

CT画像より得られた膀胱側腔、直腸側腔の画像情報をもとに考察した広汎子宮全摘出術

AOKI DAISUKE

産婦人科手術 26 71 - 78 2015.06

Joint Work

家族歴の取り方－家系図の書き方とリスクアセスメント

AOKI DAISUKE

産科と婦人科 82 ( 6 ) 619 - 626 2015.06

Joint Work

細菌糖脂質に対する免疫反応、および免疫不全に伴う消化管の細菌受容体糖脂質のフコシル化

AOKI DAISUKE

脂質生化学研究 57 203 - 206 2015.05

Joint Work

Hysteroscopic transcervical resection is useful to diagnose myometrial invasion in atypical polypoid adenomyoma coexisting with atypical endometrial hyperplasia or endometrial cancer with suspicious myometrial invasion

Yamagami W, Susumu N, Ninomiya T, Nakadaira N, Iwasa N, Kuwahata M, Nomura H, Kataoka F, Banno K, Aoki D

J Obstet Gynaecol Res 41 ( 5 ) 768 - 775 2015.05

Research paper (scientific journal), Joint Work

A Phase II clinical trial of pegylated liposomal doxorubicin and carboplatin in Japanese patients with platinum-sensitive recurrent ovarian, fallopian tube or primary peritoneal cancer

Nakanishi T, Aoki D, Watanabe Y, Ando Y, Tomotsugu N, Sato Y, Saito T

Jpn J Clin Oncol 45 ( 5 ) 422 - 426 2015.05

Research paper (scientific journal), Joint Work

：今月の臨床　早産の予知・予防の新たな展開早産の予防．，69（3）：334-338，2015．4

AOKI DAISUKE

臨床婦人科産科 69 ( 3 ) 334 - 338 2015.04

Joint Work

Correction: LATS1 and LATS2 Phosphorylate CDC26 to Modulate Assembly of the Tetratricopeptide Repeat Subcomplex of APC/C

Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S

PLoS One 10 ( 4 ) e0125308 2015.04

Joint Work

Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer

Umene K, Yanokura M, Banno K, Irie H, Adachi M, Iida M, Nakamura K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D

Int J Oncol 46 ( 4 ) 1498 - 1506 2015.04

Research paper (scientific journal), Joint Work

当科健康維持外来初診患者に認められた甲状腺機能異常の現状

AOKI DAISUKE

日本女性医学学会雑誌 22 ( 2 ) 133 - 137 2015.04

Joint Work

子宮体がんの予防とへするケア－妊孕性温存と術後のQOL改善を目指して－

AOKI DAISUKE

日本女性医学学会雑誌 22 ( 2 ) 282 2015.04

Joint Work

Efficacy of 18-FDG PET-CT dual-phase scanning for detection of lymph node metastasis in gynecological cancer

Nogami, Y., Banno, K., Irie, H., Iida, M., Masugi, Y., Murakami, K. and Aoki, D.

Anticancer Res 35 ( 4 ) 2247 - 53 2015.04

ISSN 1791-7530

当科健康維持外来初診患者に認められた甲状腺機能異常の現状

AOKI DAISUKE

日本女性医学学会雑誌 22 ( 2 ) 133 - 137 2015.04

子宮内膜癌治療における臨床試験の現況－抗がん剤を中心に－

AOKI DAISUKE

産婦人科の実際 64 ( 5 ) 669 - 677 2015.03

Joint Work

Risk-reducing surgery in hereditary gynecological cancer: Clinical applications in Lynch syndrome and hereditary breast and ovarian cancer

Adachi M, Banno K, Yanokura M, Iida M, Nakamura K, Nogami Y, Umene K, Masuda K, Kisu I, Ueki A, Hirasawa A, Tominaga E, Aoki D

Mol Clin Oncol 3 ( 2 ) 267 - 273 2015.03

Research paper (scientific journal), Joint Work

Drug repositioning for gynecologic tumors: A new therapeutic strategy for cancer

Banno K, Iida M, Yanokura M, Irie H, Masuda K, Kobayashi Y, Tominaga E, Aoki D

Scientific World Journal 2015 341362 2015.03

Joint Work

Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers

Kobayashi Y, Nakamura K, Nomura H, Banno K, Irie H, Adachi M, Iida M, Umene K, Nogami Y, Masuda K, Kisu I, Ueki A, Yamagami W, Kataoka F, Hirasawa A, Tominaga E, Susumu N, Aoki D

Int J Gynecol Cancer 25 ( 3 ) 440 - 446 2015.03

Research paper (scientific journal), Joint Work

Lynch症候群の診断

AOKI DAISUKE

産科と婦人科 82 ( Suupl. ) 189 - 193 2015.03

遺伝性乳癌卵巣癌の遺伝子検査

AOKI DAISUKE

産科と婦人科 82 ( Suupl. ) 202 - 205 2015.03

遺伝性乳癌・卵巣癌とLynch症候群のリスク低減手術

AOKI DAISUKE

産婦人科の実際 64 ( 3 ) 377 - 383 2015.03

Joint Work

婦人科領域における開腹・腟式手術の主な術式

AOKI DAISUKE

手術看護エキスパート 8 ( 6 ) 48 - 53 2015.03

Joint Work

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology

Yamagami W, Aoki D

J Obstet Gynaecol Res 41 ( 2 ) 167 - 177 2015.02

Research paper (scientific journal), Joint Work

LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C

Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S

PLoS One 10 ( 2 ) e0118662 2015.02

Research paper (scientific journal), Joint Work

Performance of p16INK4a/Ki-67 immunocytochemistry for identifying CIN2+ in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion specimens: a Japanese Gynecologic Oncology Group study

Fujii T, Saito M, Hasegawa T, Iwata T, Kuramoto H, Kubushiro K, Ohmura M, Ochiai K, Arai H, Sakamoto M, Motoyama T, Aoki D

Int J Clin Oncol 20 ( 1 ) 134 - 142 2015.02

Research paper (scientific journal), Joint Work

Cytokine profile in cervical mucosa of Japanese patients with cervical intraepithelial neoplasia

Iwata T, Fujii T, Morii K, Saito M, Sugiyama J, Nishio H, Morisada T, Tanaka, K, Yaguchi T, Kawakami Y, Aoki D

Int J Clin Oncol 20 ( 1 ) 126 - 133 2015.02

Research paper (scientific journal), Joint Work

Patient Health Questionnaire(PHQ)-9への記入結果からみた当科「健康維持外来」初診患者におけるうつ病性障害の現状

杉本到，牧田和也，横田めぐみ，堀場裕子，岩田　卓，小川真里子，弟子丸亮太，柳本茂久，高松潔，青木大輔

更年期と加齢のヘルスケア 13 ( 2 ) 291 - 298 2015.02

Research paper (scientific journal), Joint Work

若年子宮頸がんに対する妊孕能温存手術の個別化

AOKI DAISUKE

臨床婦人科産科 69 ( 1 ) 53 - 58 2015.01

Joint Work

Expression of sulfatide and sulfated lactosylceramide among histological types of human ovarian carcinomas

Tanaka K, Mikami M, Aoki D, Kiguchi K, Ishiwata I, Iwamori M

Hum Cell 28 ( 1 ) 37 - 43 2015.01

Research paper (scientific journal), Joint Work

Osteoporosis is less frequent in endometrial cancer survivors with hypertriglyceridemia

Hirasawa A, Makita K, Akahane T, Yamagami W, Makabe T, Yokota M, Horiba Y, Ogawa M, Yanamoto S, Deshimaru R, Tominaga E, Banno K, Susumu N, Aoki D

Jpn J Clin Oncol 45 ( 11 ) 127 - 131 2015.01

Research paper (scientific journal), Joint Work

Repair of congenital 'disconnected uterus': a new female genital anomaly?

Kisu, I., Tanaka, K., Banno, K., Okuda, S. and Aoki, D.

Hum Reprod 30 ( 1 ) 46 - 8 2015.01

ISSN 1460-2350

Access to Document (DOI)

The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer: clinical and pathological factors influencing it

Nogami, Y., Banno, K., Irie, H., Iida, M., Kisu, I., Masugi, Y., Tanaka, K., Tominaga, E., Okuda, S., Murakami, K. and Aoki, D.

Jpn J Clin Oncol 45 ( 1 ) 26 - 34 2015.01

ISSN 1465-3621

Access to Document (DOI)

MicroRNAS in endometrial cancer: recent advances and potential clinical applications

Yanokura, M., Banno, K., Iida, M., Irie, H., Umene, K., Masuda, K., Kobayashi, Y., Tominaga, E. and Aoki, D.

Excli j 14 190 - 8 2015

Joint Work, ISSN 1611-2156

Endometrial cancer is a common malignant gynecological tumor, but there are few biomarkers that are useful for early and accurate diagnosis and few treatments other than surgery. However, use of microRNAs (miRNAs) that induces gene downregulation in cells may permit effective and minimally invasive diagnosis and treatment. In endometrial cancer cells, expression levels of miRNAs including miR-185, miR-210 and miR-423 are upregulated and those of miR-let7e, miR-30c and miR-221 are downregulated compared to normal tissues, and these miRNAs are involved in carcinogenesis, invasion and metastasis. miRNAs with expression changes such as miR-181b, miR-324-3p and miR-518b may be used as prognostic biomarkers and transfection of miR-152 may inhibit cancer growth. However, most current studies of miRNAs are at a basic level and further work is needed to establish clinical applications targeting miRNAs.

Access to Document (DOI)

Pathological factors associated with omental metastases in endometrial cancer

Sakai, K., Yamagami, W., Susumu, N., Nomura, H., Kataoka, F., Banno, K., Tsuda, H. and Aoki, D.

Eur J Gynaecol Oncol 36 ( 4 ) 397 - 401 2015

Joint Work, ISSN 0392-2936

Effectiveness of third-line chemotherapy in recurrent ovarian cancer patients

Yoshihama, T., Chiyoda, T., Kataoka, F., Nomura, H., Iguchi, Y., Hashimoto, S., Yamagami, W., Tominaga, E., Susumu, N., Tsuda, H. and Aoki, D.

Eur J Gynaecol Oncol 36 ( 4 ) 424 - 7 2015

Joint Work, ISSN 0392-2936

Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women: analysis of 41 cases in Japan

Morikawa A, Ueda K, Takahashi K, Fukunaga M, Iwashita M, Kobayashi Y, Takechi K, Umezawa S, Terauchi F, Kiguchi K, Aoki D, Nomura H, Yoshikawa H, Satoh T, JoboT, Fujiwara H, Takei Y, Kamoi S, Terao Y, Isonishi S

Int J Clin Oncol 19 ( 6 ) 1074 - 1079 2014.12

Research paper (scientific journal), Joint Work

Ovarian Cancer

Song YS, Kim HS, Aoki D, Dhanasekaran DN, Tsang BK

Biomed Res Int 2014 764323 2014.12

Research paper (scientific journal), Joint Work

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Uterine Serous Carcinoma

Sagae S, Susumu N, Viswanathan AN, Aoki D, Backes FJ, Provencher DM, Vaughan M, Creutzberg CL, Kurzeder C, Kristensen G, Lee C, Kurtz JE, Glasspool RM, Small W Jr

Int J Gynecol Cancer 24 ( 9 Suppl 3 ) S83 - S89 2014.11

Research paper (scientific journal), Joint Work

Features of ovarian cancer in Lynch syndrome (Review)

Nakamura K, Banno K, Yanokura M, Iida M, Adachi M, Masuda K, Ueki A, Kobayashi Y, Nomura H, Hirasawa A, Tominaga E, Aoki D

Mol Clin Oncol 2 ( 6 ) 909 - 916 2014.11

Research paper (scientific journal), Joint Work

Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Ovary

Okamoto A, Glasspool RM, Mabuchi S, Matsumura N, Nomura H, Itamochi H, Takano M, Takano T, Susumu N, Aoki D, Konishi I, Covens A, Ledermann J, Mezzazanica D, Steer C, Millan D, McNeish IA, Pfisterer J, Kang S, Gladieff L, Bryce J, Oza A

Int J Gynecol Cancer 24 ( 9 Suppl 3 ) S20 - S25 2014.11

Research paper (scientific journal), Joint Work

Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women

Azuma Y, Kusumoto-Matsuo R, Takeuchi F, Uenoyama A, Kondo K, Tsunoda H, Nagasaka K, Kawana K, Morisada T, Iwata T, Aoki D, Kukimoto I

Jpn J Clin Oncol 44 ( 10 ) 910 - 917 2014.10

Research paper (scientific journal), Joint Work

Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review)

Iida M, Banno K, Yanokura M, Nakamura K, Adachi M, Nogami Y, Umene K, Masuda K, Kisu I, Iwata T, Tanaka K, Aoki D

Mol Clin Oncol 2 ( 5 ) 647 - 655 2014.09

Joint Work

Simultaneous analysis of the gene expression profiles of cancer and stromal cells in endometrial cancer

Iguchi Y, Ito YM, Kataoka F, Nomura H, Tanaka H, Chiyoda T, Hashimoto S, Nishimura S, Takano M, Yamagami W, Susumu N, Aoki D, Tsuda H

Genes Chromosomes Cancer 53 ( 9 ) 725 - 737 2014.09

Joint Work

遺伝性婦人科腫瘍

AOKI DAISUKE

日本産科婦人科学会雑誌 66 ( 8 ) 1997 - 2006 2014.08

Research paper (scientific journal), Single Work

Laparoscopic surgery for early ovarian cancer

AOKI DAISUKE

J Gynecol Oncol 25 ( 3 ) 168 - 169 2014.07

Single Work

A retrospective study on combination therapy with ifosfamide, adriamycin and cisplatin for progressive or recurrent uterine sarcoma

Yamagami W, Susumu N, Ninomiya T, Kuwahata M, Takigawa A, Nomura H, Kataoka F, Tominaga E, Banno K, Tsuda H, Aoki D

Mol Clin Oncol 2 ( 4 ) 591 - 595 2014.07

Research paper (scientific journal), Joint Work

Trends in gynecologic cancer mortality in East Asian regions

Lee JY, Kim EY, Jung KW, Shin A, Chan KK, Aoki D, Kim JW, Low JJ, Won YJ

J Gynecol Oncol 25 ( 3 ) 174 - 182 2014.07

Research paper (scientific journal), Joint Work

子宮頸部円錐切除術後の出血に関する検討

AOKI DAISUKE

東京産科婦人科学会会誌 63 ( 03 ) 394 - 399 2014.07

Joint Work

Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor

Nishio H, Yaguchi T, Sugiyama J, Sumimoto H, Umezawa K, Iwata T, Susumu N, Fujii T, Kawamura N, Kobayashi A, Park J, Aoki D, Kawakami Y

Br J Cancer 110 ( 12 ) 2965 - 2974 2014.06

Research paper (scientific journal), Joint Work

Clinicopathological study on para-aortic lymph node metastasis without pelvic lymph node metastasis in endometrial cancer

Tomisato S, Yamagami W, Susumu N, Kuwahata M, Takigawa A, Nomura H, Kataoka F, Hirasawa A, Banno K, Aoki D

J Obstet Gynaecol Res 40 ( 6 ) 1733 - 1739 2014.06

Research paper (scientific journal), Joint Work

乳酸菌の腸内共生と免疫の役割

AOKI DAISUKE

脂質生化学研究 56 183 - 186 2014.05

Joint Work

Uterine transplantation in primates: a mini-review of the literature

Kisu I, Banno K, Mihara M, Hara H, Kato Y, Suganuma N, Aoki D

Transplant Proc 46 ( 4 ) 1212 - 1216 2014.05

Research paper (scientific journal), Joint Work

転写因子HOXD9の子宮頸癌での発現検討と細胞増殖に与える影響

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 29 42 - 43 2014.04

Joint Work

Surgical anatomy imaging associated with cervical cancer treatment: A cadaveric study

Nakamura M, Fujii T, Imanishi N, Jinzaki M, Yamada M, Kuribayashi S, Aoki D

Clin Anat 27 ( 3 ) 503 - 510 2014.04

Joint Work

Uterus allotransplantation in cynomolgus macaque: A preliminary experience with non-human primate models

Kisu I, Mihara M, Banno K, Hara H, Masugi Y, Araki J, Iida T, Yamada Y, Kato Y, Shiina T, Suganuma N, Aoki D

J Obstet Gynaecol Res 40 ( 4 ) 907 - 918 2014.04

Research paper (scientific journal), Joint Work

当院健康維持外来における慢性頭痛に対する呉茱萸湯の検討

AOKI DAISUKE

産婦人科漢方研究のあゆみ 31 89 - 93 2014.04

Joint Work

ESBL産生E.coliにより妊娠中期に敗血症を発症した絨毛膜羊膜炎の1例

AOKI DAISUKE

東京産科婦人科学会会誌 63 ( 2 ) 314 - 317 2014.04

Joint Work

子宮癌の子宮温存療法後の妊孕能と生殖補助医療

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 32 ( 2 ) 111 - 116 2014.04

Joint Work

子宮移植の現状～子宮性不妊患者に対する妊孕性再建技術の可能性～

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 32 ( 2 ) 135 - 141 2014.04

Joint Work

早期子宮体癌における腹腔鏡下手術

AOKI DAISUKE

産科と婦人科 81 ( Suppl. ) 157 - 164 2014.03

Joint Work

子宮内膜症性病巣に対するジエノゲスト効果に関する網羅的遺伝子発現解析

AOKI DAISUKE

産婦人科の実際 63 ( 3 ) 477 - 481 2014.03

Joint Work

子宮頸癌における妊孕性温存術式

AOKI DAISUKE

産科と婦人科 81 ( Suppl. ) 109 - 113 2014.03

Joint Work

Glycan profiling of gestational choriocarcinoma using a lectin microarray

Kobayashi Y, Masuda K, Banno K, Kobayashi N, Umene K, Nogami Y, Tsuji K, Ueki A, Nomura H, Sato K, Tominaga E, Shimizu T, Saya H, Aoki D

Oncol Rep 31 ( 3 ) 1121 - 1126 2014.03

Research paper (scientific journal), Joint Work

細胞傷害性T細胞を用いた免疫療法

AOKI DAISUKE

産科と婦人科 81 ( 2 ) 151 - 156 2014.02

Joint Work

A tumor of the uterine cervix with a complex histology in a Peutz-Jeghers syndrome patient with genomic deletion of the STK11 exon 1 region

Kobayashi Y, Masuda K, Kimura T, Nomura H, Hirasawa A, Banno K, Susumu N, Sugano K, Aoki D

Future Oncol 10 ( 2 ) 171 - 177 2014.02

Research paper (scientific journal), Joint Work

Application of FDG-PET in cervical cancer and endometrial cancer: utility and future prospects

Nogami Y, Iida M, Banno K, Kisu I, Adachi M, Nakamura K, Umene K, Masuda K, Tominaga E, Tanaka K, Aoki D

Anticancer Res 34 ( 2 ) 585 - 592 2014.02

Research paper (scientific journal), Joint Work

Annual report of Gynecologic Oncology Committee, Japan Society of Obstetrics and Gynecology, 2013

AOKI DAISUKE

J Obstet Gynaecol Res 40 ( 2 ) 338 - 348 2014.02

Joint Work

がん免疫病態の細胞分子機構

AOKI DAISUKE

産科と婦人科 81 ( 2 ) 145 - 150 2014.02

Joint Work

当院で経験した前置血管症例の周産期臨床像の検討－超音波検査および胎盤所見を中心に－

AOKI DAISUKE

東京産科婦人科学会会誌 63 ( 1 ) 30 - 35 2014.01

Joint Work

Family History and BRCA1/BRCA2 Status Among Japanese Ovarian Cancer Patients and Occult Cancer in a BRCA1 Mutant Case

Hirasawa, Akira, Masuda, Kenta, Akahane, Tomoko, Ueki, Arisa, Yokota, Megumi, Tsuruta, Tomohiko, Nomura, Hiroyuki, Kataoka, Fumio, Tominaga, Eiichiro, Banno, Kouji, Makita, Kazuya, Susumu, Nobuyuki, Sugano, Kokichi, Kosaki, Kenjiro, Kameyama, Kaori, Aoki, Daisuke

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 44 ( 1 ) 49 - 56 2014.01

Research paper (scientific journal), Joint Work, ISSN 0368-2811

Access to Document (DOI)

Case of streptococcal toxic shock syndrome caused by rapidly progressive group a hemolytic streptococcal infection during postoperative chemotherapy for cervical cancer

Nogami Y, Tsuji K, Banno K, Umene K, Katakura S, Kisu I, Tominaga E, Aoki D

J Obstet Gynaecol Res 40 ( 1 ) 250 - 254 2014.01

Research paper (scientific journal), Joint Work

腹式広汎性子宮頸部摘出術

AOKI DAISUKE

産婦人科の実際 63 ( 1 ) 45 - 48 2014.01

Joint Work

子宮腔内細胞診および子宮内膜組織診後に入院加療を要した骨盤内炎症性疾患の検討

AOKI DAISUKE

東京産科婦人科学会会誌 63 ( 1 ) 7 - 12 2014.01

Research paper (scientific journal), Joint Work

MicroRNA in Cervical Cancer: OncomiRs and Tumor Suppressor miRs in Diagnosis and Treatment

Banno, Kouji, Iida, Miho, Yanokura, Megumi, Kisu, Iori, Iwata, Takashi, Tominaga, Eiichiro, Tanaka, Kyoko, Aoki, Daisuke

SCIENTIFIC WORLD JOURNAL 2014

Research paper (scientific journal), ISSN 1537-744X

Access to Document (DOI)

Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients

Hirasawa A, Zama T, Akahane T, Nomura H, Kataoka F, Saito K, Okubo K, Tominaga E, Makita K, Susumu N, Kosaki K, Tanigawara Y, Aoki D

J Hum Genet 58 ( 12 ) 794 - 798 2013.12

Research paper (scientific journal), Joint Work

Risks for Donors in Uterus Transplantation

Kisu I, Mihara M, Banno K, Umene K, Araki J, Hara H, Suganuma N, Aoki D

Reprod Sci 20 ( 12 ) 1406 - 1415 2013.12

Research paper (scientific journal), Joint Work

Indocyanine green fluorescence imaging in the pregnant cynomolgus macaque: childbearing is supported by a unilateral uterine artery and vein alone?

Kisu I, Banno K, Yanokura M, Nogami Y, Umene K, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Aoki D:

Arch Gynecol Obstet 288 ( 6 ) 1309 - 1315 2013.12

Research paper (scientific journal), Joint Work

遺伝性乳癌卵巣癌（HBOC）症候群

AOKI DAISUKE

日本産婦人科医会報 65 ( 10 ) 8 - 9 2013.11

Single Work

子宮移植は可能か？－世界初の霊長類における自家子宮移植後の妊娠出産報告と形成外科医からの視点－

AOKI DAISUKE

産婦人科の実際 62 ( 11 ) 1541 - 1549 2013.11

Joint Work

Hereditary gynecological tumors associated with Peutz-Jeghers syndrome (Review)

Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Hirasawa A, Aoki D

Oncol Lett 6 ( 5 ) 1184 - 1188 2013.11

Research paper (scientific journal), Joint Work

Hypertriglyceridemia is Frequent in Endometrial Cancer Survivors

Hirasawa A, Makita K, Akahane T, Yokota M, Yamagami W, Banno K, Susumu N, Aoki D

Jpn J ClinOncol 43 ( 11 ) 1087 - 1092 2013.11

Joint Work

遺伝性乳癌・卵巣癌女性への遺伝カウンセリング

AOKI DAISUKE

産科と婦人科 80 ( 11 ) 1465 - 1472 2013.11

Joint Work

子宮鏡検査

AOKI DAISUKE

産婦人科の実際臨時増刊号 62 ( 12 ) 1756 - 1762 2013.11

Joint Work

国内外の子宮体がんの臨床試験の現状

AOKI DAISUKE

産婦人科の実際臨時増刊号 62 ( 12 ) 1828 - 1842 2013.11

Joint Work

卵巣がんの臨床試験

AOKI DAISUKE

産婦人科の実際臨時増刊号 62 ( 12 ) 1985 - 1991 2013.11

Joint Work

婦人科疾患に伴う痛み

AOKI DAISUKE

診断と治療 101 ( 11 ) 1679 - 1683 2013.11

Joint Work

妊娠初期の人工妊娠中絶後に大量性器出血をきたした胎盤ポリープの1例

AOKI DAISUKE

東京産科婦人科学会会誌 62 ( 4 ) 562 - 567 2013.10

Joint Work

子宮がん疾患の理解編

AOKI DAISUKE

Clinical Study 34 ( 11 ) 41-48 2013.10

Research paper (scientific journal), Joint Work

Distinguishing between lymphangioleiomyomatosis and carcinomatous peritonitis in a patient with ovarian cancer

Hirasawa A, Sato T, Ueno M, Akahane T, Susumu N, Betsuyaku T, Aoki D

J Clin Oncol 31 ( 28 ) e427-e429 2013.10

Research paper (scientific journal), Joint Work

ナーシングプロセス：子宮がん疾患の理解編

AOKI DAISUKE

Clinical Study 34 ( 11 ) 41-48 2013.10

Research paper (scientific journal), Joint Work

当科健康維持外来受診患者からみた「めまい」の現状

AOKI DAISUKE

日本女性医学学会雑誌 21 ( 1 ) 54 - 59 2013.09

Joint Work

Methylation of human papillomavirus-52 and -58 is a candidate biomarker in cervical neoplasia

Murakami I, Fujii T, Dan K, Saito M, Ohno A, Iwata T, Aoki D

J Clin Virol 58 ( 1 ) 149-154 2013.09

Research paper (scientific journal), Joint Work

Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trial

Katsumata N, Yasuda M, Isonishi S, Takahashi F, Michimae H, Kimura E, Aoki D, Jobo T, Kodama S, Terauchi F, Sugiyama T, Ochiai K; Japanese Gynecologic Oncology Group

Lancet Oncol 14 ( 10 ) 1020-1026 2013.09

Research paper (scientific journal), Joint Work

子宮体がんとエストロゲン

AOKI DAISUKE

産婦人科の実際 62 ( 9 ) 1181-1187 2013.09

Research paper (scientific journal), Joint Work

Current status of molecular-targeted drugs for endometrial cancer (Review).

Nogami Y, Banno K, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D

Mol Clin Oncol 1 ( 5 ) 799 - 804 2013.09

Research paper (scientific journal), Joint Work

家族性子宮体がんと遺伝子異常

AOKI DAISUKE

臨床婦人科産科 67 ( 8 ) 818-824 2013.08

Research paper (scientific journal), Joint Work

Uterine transplantation: towards clinical application

Kisu I, Banno K, Mihara M, Suganuma N, Aoki D

Gynecol Obstet Invest 76 ( 1 ) 74 2013.08

Research paper (scientific journal), Joint Work

Osler-Weber-Rendu病を合併した子宮体癌の1例

AOKI DAISUKE

東京産科婦人科学会誌 62 ( 3 ) 372 - 376 2013.07

Joint Work

Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies

Nishio H, Fujii T, Sugiyama J, Kuji N, Tanaka M, Hamatani T, Miyakoshi K, Minegishi K, Tsuda H, Iwata T, Tanaka K, Fukuchi T, Takehara Y, Yoshimura Y, Aoki D

Hum Reprod 28 ( 7 ) 1793-1798 2013.07

Research paper (scientific journal), Joint Work

p16INK4a immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping

Nishi S, Fujii T, Nishio H, Kameyama K, Saito M, Iwata T, Kubushito K, Aoki D

J Gynecol Oncol 24 ( 3 ) 215-221 2013.07

Research paper (scientific journal), Joint Work

Current status of uterus transplantation in primates and issues for clinical application

Kisu I, Banno K, Mihara M, Suganuma N, Aoki D

Fertil Steril 100 ( 1 ) 280-294 2013.07

Research paper (scientific journal), Joint Work

Evaluation of clinical usefulness of a medical monitor equipped with an organic electroluminescence panel in comparison with liquid crystal display monitors

Kataoka F, Nomura H, Nogami Y, Arima H, Sawano Y, Banno K, Fujii T, Aoki D

J Minim Invasive Gynecol 20 ( 4 ) 522-528 2013.07

Research paper (scientific journal), Joint Work

β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation

Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G

Oncogene 32 ( 29 ) 3477-3482 2013.07

Research paper (scientific journal), Joint Work

Uterus transplantation in nonhuman primates

Kisu I, Banno K, Mihara M, Aoki D

Fertil Steril 100 ( 1 ) e3 2013.07

Research paper (scientific journal), Joint Work

子宮性不妊女性に対する妊孕性再建を目指した子宮移植手術

AOKI DAISUKE

臨床婦人科産科 67 ( 7 ) 745-751 2013.07

Research paper (scientific journal), Joint Work

日本臨床細胞学会の今後の取り組み－国際学会（19th ICC 2016）に向けて－

AOKI DAISUKE

日本臨床細胞学会東北支部連合会会報 33 7 - 14 2013.06

Single Work

Candidate biomarkers for genetic and clinicopathological diagnosis of endometrial cancer

Banno K, Nogami Y, Kisu I, Yanokura M, Umene K, Masuda K, Kobayashi Y,Yamagami W, Susumu N, Aoki D

Int J Mol Sci 14 ( 6 ) 12123-12137 2013.06

Research paper (scientific journal), Joint Work

子宮体がんの術後再発リスク評価と術後療法

AOKI DAISUKE

臨床婦人科産科 67 ( 5 ) 474-484 2013.05

Research paper (scientific journal), Joint Work

Aurora kinase inhibitors: Potential molecular-targeted drugs for gynecologic malignant tumors

Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D

Biomed Rep 1 ( 3 ) 335 - 340 2013.05

Research paper (scientific journal), Joint Work

Preoperative and intraoperative assessment of myometrial invasion in endometrial cancer: Comparison of magnetic resonance imaging and frozen section

Kisu I, Banno K, Lin LY, Ueno A, Abe T, Kouyama K, Okuda S, Masugi Y, Umene K, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Susumu N, Aoki D

Acta Obstet Gynecol Scand 92 ( 5 ) 525-535 2013.05

Research paper (scientific journal), Joint Work

Experience of Risk-reducing Salpingo-oophorectomy for a BRCA1 Mutation Carrier and Establishment of a System Performing a Preventive Surgery for Hereditary Breast and Ovarian Cancer Syndromein Japan: Our Challenges for the Future

Hirasawa A, Masuda K, Akahane T, Tsuruta T, Banno K, Makita K, Susumu N, Jinno, H, Kitagawa Y, Sugano K, Kosaki K, Aoki D

Jpn J Clin Oncol 43 ( 5 ) 515-519 2013.05

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術における妊孕能向上への工夫

AOKI DAISUKE

産婦人科手術 24 37-42 2013.05

Research paper (scientific journal), Joint Work

無月経を呈するも卵巣予備能を有するターナー症候群の1例

AOKI DAISUKE

東京産科婦人科学会会誌 62 ( 2 ) 231-235 2013.04

Research paper (scientific journal), Joint Work

MicroRNAs in endometrial cancer

Banno K, Yanokura M, Kisu I, Yamagami W, Susumu N, Aoki D

Int J Clin Oncol 18 ( 2 ) 186-192 2013.04

Research paper (scientific journal), Joint Work

長期的なホットフラッシュに三物黄芩湯が有効であった1例

堀場裕子，牧田和也，横田めぐみ，岩田　卓，青木大輔，吉村泰典

産婦人科漢方研究のあゆみ 30 30 - 33 2013.04

Research paper (scientific journal), Joint Work

適切な血糖管理により良好な経過をたどった糖原病Ia型合併妊娠の一例

AOKI DAISUKE

関東連合産科婦人科学会誌 50 ( 1 ) 129 - 134 2013.03

Joint Work

New candidate therapeutic agents for endometrial cancer: Potential for clinical practice (Review)

Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Tominaga E, Susumu N, Aoki D

Oncol Rep 29 ( 3 ) 855-860 2013.03

Research paper (scientific journal), Joint Work

Rapid genotyping of carcinogenic human papillomavirus by loop-mediated isothermal amplification using a new automated DNA test (Clinichip HPV™)

Satoh T, Matsumoto K, Fujii T, Sato O, Gemma N, Onuki M, Saito H, Aoki D, Hirai Y, Yoshikawa H

J Virol Methods 188 ( 1-2 ) 83-93 2013.03

Research paper (scientific journal), Joint Work

子宮体癌の再発を予測できる間質遺伝子の発現に基づいた卵巣癌症例のグループ化

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 28 29-30 2013.03

Research paper (scientific journal), Joint Work

子宮動脈塞栓術により救命しえた子宮摘出困難な分娩後大量出血の2例

AOKI DAISUKE

関東連合産科婦人科学会誌 50 ( 1 ) 63-68 2013.03

Research paper (scientific journal), Joint Work

子宮頸がん検診のトピックス

AOKI DAISUKE

国立がん研究センターがん対策情報センターがん検診受診向上指導事業全国がん検診指導者講習会 2013.02

Research paper (other academic), Single Work

研修1：総論がん検診の精度管理　マネジメント各論（子宮頸がん）

AOKI DAISUKE

国立がん研究センターがん対策情報センターがん検診受診向上指導事業全国がん検診指導者講習会 2013.02

Research paper (other academic), Single Work

研修2：生活習慣病検診等管理指導協議会の具体的な活動内容子宮頸がん検診の精度管理調査の手法について．

AOKI DAISUKE

国立がん研究センターがん対策情報センターがん検診受診向上指導事業全国がん検診指導者講習会 2013.02

Research paper (other academic), Single Work

Gene expression profile of a newlyestablished choriocarcinoma cell line, iC(3)-1, compared to existing choriocarcinoma cell lines and normal placenta

Kobayashi Y, Banno K, Shimizu T, Ueki A, Tsuji K, Masuda K, Kisu I, Nomura H, Tominaga E, Nagano O, Saya H, Aoki D

Placenta 34 ( 2 ) 110-118 2013.02

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術の適応とその問題点

AOKI DAISUKE

産婦人科の実際 62 ( 1 ) 19 - 23 2013.01

Joint Work

HMMC-1, a human monoclonal antibody to fucosylated core 1 O-glycan, suppresses growth of uterine endometrial cancer cells

Oikawa F, Kojima-Aikawa K, Inoue F, Suzuki A, Tanaka K, Tominaga E, Aoki D

Cancer Sci 104 ( 1 ) 62-69 2013.01

Research paper (scientific journal), Joint Work

The Origin of Stroma Surrounding Epithelial Ovarian Cancer Cells

Akahane T, Hirasawa A, Tsuda H, Kataoka F, Nishimura S, Tanaka H, Tominaga E, Nomura H, Chiyoda T, Iguchi Y, Yamagami W, Susumu N, Aoki D

Int J Gynecol Pathol 32 ( 1 ) 26-30 2013.01

Research paper (scientific journal), Joint Work

転移性脳腫瘍による動眼神経麻痺が契機となって発見された子宮体癌の1例

AOKI DAISUKE

東京産科婦人科学会会誌 62 ( 1 ) 91-95 2013.01

Research paper (scientific journal), Joint Work

経腟Hybrid NOTESにより婦人科・外科2領域同時手術を施行した1例

AOKI DAISUKE

東京産科婦人科学会会誌 62 ( 1 ) 144 - 148 2013.01

Research paper (scientific journal), Joint Work

子宮峡部癌の臨床病理学的特徴とLynch症候群との関連

AOKI DAISUKE

家族性腫瘍 13 ( 1 ) 1 - 5 2013.01

Joint Work

目で見る生殖機能温存手術－子宮頸癌－

AOKI DAISUKE

HORMONE FRONTIER IN GYNECOLOGY 19 ( 4 ) 4-6 2012.12

Research paper (scientific journal), Joint Work

Possible involvement of glycolipids in anticancer drug resistance of human ovarian serous carcinoma-derived cells

Tanaka K, Takada H, Isonishi S, Aoki D, Mikami M, Kiguchi K, Iwamori M

J Biochem 152 ( 6 ) 587-594 2012.12

Research paper (scientific journal), Joint Work

Up-regulation of imp3 confers in vivo tumorigenicity on murine osteosarcoma cells

Ueki A, Shimizu T, Masuda K, Yamaguchi SI, Ishikawa T, Sugihara E, Onishi N, Kuninaka S, Miyoshi K, Muto A, Toyama Y, Banno K, Aoki D, Saya H

PLoS One 7 ( 11 ) e50621 2012.12

Research paper (scientific journal), Joint Work

当院における若年症例の外陰部腫瘍手術に対する新しい取り組み

AOKI DAISUKE

関東連合産科婦人科学会誌 49 ( 4 ) 649-654 2012.11

Research paper (scientific journal), Joint Work

Relationship of lower uterine segment cancer with Lynch syndrome: A novel case with an hMLH1 germline mutation

Masuda K, Banno K, Hirasawa A, Yanokura M, Tsuji K, Kobayashi Y, Kisu I, Ueki A, Nomura H, Tominaga E, Susumu N, Aoki D

OncolRep 28 ( 5 ) 1537-1543 2012.11

Research paper (scientific journal), Joint Work

Lobular endocervical glandular hyperplasia and peritoneal pigmentation associated with Peutz-Jeghers syndrome due to a germline mutation of STK11

Hirasawa A, Akahane T, Tsututa T, Kobayashi Y, Masuda K, Banno K, Fujii T, Susumu N, Itsubo T, Kameyama K, Sugano K, Aoki D: Lobular endocervical

Ann Oncol 23 ( 11 ) 2990-2992 2012.11

Research paper (scientific journal), Single Work

更年期障害の諸症状に対する加味逍遙散、ホルモン補充療法の効果比較－無作為割付研究の結果より－

AOKI DAISUKE

日本女性医学学会雑誌 20 ( 2 ) 305-312 2012.10

Research paper (scientific journal), Joint Work

Association of epigenetic inactivationof the WRN gene with anticancer drug sensitivity in cervical cancer cells

Masuda K, Banno K, Yanokura M, Tsuji K, Kobayashi Y, Kisu I, Ueki A, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D

Oncol Rep 28 ( 4 ) 1146-1152 2012.10

Research paper (scientific journal), Joint Work

卵巣明細胞腺癌における子宮内膜症共存の臨床的および生物学的意義－TGFβ signalingの関与を中心として

AOKI DAISUKE

産科と婦人科 79 ( 10 ) 1225-1231 2012.10

Research paper (scientific journal), Joint Work

子宮肉腫

AOKI DAISUKE

産婦人科の実際 61 ( 11（10月臨時増刊号） ) 1800-1805 2012.10

Research paper (scientific journal), Joint Work

Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review)

Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D

Int J Oncol 41 ( 3 ) 793-797 2012.09

Research paper (scientific journal), Joint Work

早期子宮体がん（Ⅲa期まで）の治療

AOKI DAISUKE

からだの科学 274 80-86 2012.08

Research paper (scientific journal), Joint Work

Blood-direct InvaderPlus® as a new method for genetic testing

Hirasawa A, Akahane T, Tanigawara Y, Aoki D

Personalized Medicine 9 ( 6 ) 657-663 2012.08

Research paper (scientific journal), Joint Work

Uterine autotransplantation in cynomolgus macaques: the first case of pregnancy and delivery

Mihara M, Kisu I, Hara H, Iida T, Araki J, Shim T, Narushima M, Yamamoto T, Moriguchi H, Kato Y, Tonsho M, Banno K, Aoki D, Suganuma N, Kagawa N, Takehara Y, Kato O, Koshima I

Hum Reprod 27 ( 8 ) 2332-2340 2012.08

Research paper (scientific journal), Joint Work

Cell surface expression of hyaluronan on human ovarian cancer cells inversely correlates with their adhesionto peritoneal mesothelial cells

Tamada Y, Takeuchi H, Suzuki N, Aoki D, Irimura T

Tumour Biol 33 ( 4 ) 1215-1222 2012.08

Research paper (scientific journal), Joint Work

子宮頸癌に対する妊孕能温存術式－広汎性子宮頸部摘出術の適応と不妊治療の実際－

AOKI DAISUKE

産婦人科の実際 61 ( 8 ) 1179-1183 2012.08

Research paper (scientific journal), Joint Work

当科健康維持外来受診者における大腿骨近位部骨密度の検討

AOKI DAISUKE

Osteoporosis Japan 20 ( 3 ) 489 - 491 2012.07

Joint Work

子宮体癌に対する高用量黄体ホルモン療法後の経過観察中に血栓塞栓症を発症した2例

AOKI DAISUKE

東京産科婦人科学会会誌 61 ( 2 ) 260-264 2012.07

Research paper (scientific journal), Joint Work

第4回　手術に役立つ骨盤臨床解剖　－血管編－

AOKI DAISUKE

産科と婦人科 79 ( 7 ) 813-819 2012.07

Research paper (scientific journal), Joint Work

Tumor volume and lymphovascular space invasion as a prognostic factor in early invasive adenocarcinoma of the cervix

Murakami I, Fujii T, Kameyama K, Iwata T, Saito M, Kubushiro K, Aoki D

J Gynecol Oncol 23 ( 3 ) 153-158 2012.07

Research paper (scientific journal), Joint Work

Biomarkers in endometrial cancer: Possible clinical applications (Review)

Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D

Oncol Lett 3 ( 6 ) 1175-1180 2012.06

Research paper (scientific journal), Joint Work

Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)

Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Susumu N, Aoki D

Int J Oncol 40 ( 6 ) 1755-1762 2012.06

Research paper (scientific journal), Joint Work

プラチナ抵抗性再発卵巣癌の取扱い

AOKI DAISUKE

産科と婦人科 79 ( 6 ) 742-747 2012.06

Research paper (scientific journal), Joint Work

国際共同研究の動向－Gynecologic Cancer Intergroup(GCIG)での論議を中心に－

AOKI DAISUKE

日本臨床　婦人科がん－最新の研究動向－ 70 ( 増刊号4 ) 59-66 2012.06

Research paper (scientific journal), Joint Work

子宮体癌の家族発生と遺伝子診断

AOKI DAISUKE

日本臨床　婦人科がん－最新の研究動向－ 70 ( 増刊号4 ) 292-296 2012.06

Research paper (scientific journal), Joint Work

治療概論

AOKI DAISUKE

日本臨床　婦人科がん－最新の研究動向－ 70 ( 増刊号4 ) 381-387 2012.06

Research paper (scientific journal), Joint Work

腫瘍マーカー、バイオマーカー

AOKI DAISUKE

日本臨床　婦人科がん－最新の研究動向－ 70 ( 増刊号4 ) 543-548 2012.06

Research paper (scientific journal), Joint Work

子宮肉腫に対する薬物療法

AOKI DAISUKE

癌と化学療法 39 ( 5 ) 722-725 2012.05

Research paper (scientific journal), Joint Work

LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihama Y, Saya H, Kuninaka S

J Cell Biol 197 ( 5 ) 625-641 2012.05

Research paper (scientific journal), Joint Work

家族性腫瘍としての子宮体癌－さまざまな症候群との関連－

AOKI DAISUKE

家族性腫瘍 12 ( 2 ) 57-59 2012.05

Research paper (scientific journal), Joint Work

Bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipids in symbiotic Lactobacillus, Staphylococcus and Streptococcus species

Iwamori M, Nakasa M, Yamazaki K, Iwamori Y, Tanaka K, Aoki D, Adachi S, Nomura T

Glycoconj J 29 ( 4 ) 199-209 2012.05

Research paper (scientific journal), Joint Work

Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics

Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D

Biochem Res Int 2012 738274 2012.05

Research paper (scientific journal), Joint Work

当院における先天性横隔膜ヘルニア胎内診断例の周産期予後に関する検討

AOKI DAISUKE

東京産科婦人科学会会誌 61 ( 1 ) 11-15 2012.04

Research paper (scientific journal), Joint Work

Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice

Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D

Epigenomics 4 ( 2 ) 147-162 2012.04

Research paper (scientific journal), Joint Work

Proteomic characterization of ovarian cancers identified ANXA4, PSAT1, CRABP2 and SPB5 as histology-specific biomarkers

Toyama A, Suzuki A, Shimada T, Aoki C, Aoki Y, Umino Y, Nakamura Y, Aoki D, Sato TA

Cancer Sci 103 ( 4 ) 747-755 2012.04

Research paper (scientific journal), Joint Work

遺伝性乳癌・卵巣癌

AOKI DAISUKE

日本産科婦人科学会雑誌 64 ( 4 ) 1315-1320 2012.04

Research paper (scientific journal), Joint Work

子宮鏡検査

AOKI DAISUKE

産科と婦人科増刊号 79 ( Suppl. ) 142-151 2012.04

Research paper (scientific journal), Joint Work

子宮頸がん検診の精密検査としてのコルポスコピー

AOKI DAISUKE

産科と婦人科増刊号 79 ( Suppl. ) 108-114 2012.04

Research paper (scientific journal), Joint Work

New terminology for intrauterine endometrial samples: a group study by the Japanese society of clinical cytology

Yanoh K, Hirai Y, Sakamoto A, Aoki D, Moriya T, Hiura M, Yamawaki T, Shimizu K, Nakayama H, Sasaki H, Tabata T, Ueda M, Udagawa Y, Norimatsu Y

Acta Cytol 56 ( 3 ) 233-241 2012.04

Research paper (scientific journal), Joint Work

子宮内膜増殖症，子宮内膜ポリープ

AOKI DAISUKE

臨床婦人科産科（オフィスギネコロジー　女性のプライマリ・ケア） 66 ( 5（増刊号） ) 219-223 2012.04

Research paper (scientific journal), Joint Work

Indocyanine green fluorescence imaging for evaluation of uterine blood flow in cynomolgus macaque

Kisu I, Banno K, Mihara M, Lin LY, Tsuji K, Yanokura M, Hara H, Araki J, Iida T, Abe T, Kouyama K, Suganuma N, Aoki D

PLoS One 7 ( 4 ) e351242012 2012.04

Research paper (scientific journal), Joint Work

卵管癌の診断と治療

AOKI DAISUKE

産婦人科の実際 61 ( 3 ) 459-463 2012.03

Research paper (scientific journal), Joint Work

子宮頸癌の進行期分類と治療方針

AOKI DAISUKE

産婦人科の実際 61 ( 3 ) 301-308 2012.03

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術

AOKI DAISUKE

産婦人科の実際 61 ( 3 ) 323-328 2012.03

Research paper (scientific journal), Joint Work

「アミノインデックス技術」を用いた新規婦人科がんスクリーニング法の有用性

AOKI DAISUKE

人間ドック 26 ( 5 ) 749-755 2012.03

Research paper (scientific journal), Joint Work

EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy

Kataoka F, Tsuda H, Arao T, Nishimura S, Tanaka H, Nomura H, Chiyoda T, Hirasawa A, Akahane T, Nishio H, Nishio K, Aoki D:

Genes Chromosomes Cancer 51 ( 3 ) 300-312 2012.03

Research paper (scientific journal), Joint Work

Expression profiles of carcinosarcoma of the uterine corpus-are these similar to carcinoma or sarcoma?

Chiyoda T, Tsuda H, Tanaka H, Kataoka F, Nomura H, Nishimura S, Takano M, Susumu N, Saya H, Aoki D

Genes Chromosomes Cancer 51 ( 3 ) 229-239 2012.03

Research paper (scientific journal), Joint Work

発現解析による子宮体部癌肉腫の生物学的特性の解明

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 27 23-24 2012.02

Research paper (scientific journal), Joint Work

発現解析による子宮体癌の再発予測モデルの開発

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 27 45-46 2012.02

Research paper (scientific journal), Joint Work

卵巣明細胞癌

AOKI DAISUKE

癌と化学療法 39 ( 2 ) 198-201 2012.02

Research paper (scientific journal), Joint Work

Narrow band imaging in gynecology: A new diagnostic approach with improved visual identification (Review)

Kisu I, Banno K, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Susumu N, Aoki D

Int J Oncol 40 ( 2 ) 350-356 2012.02

Research paper (scientific journal), Joint Work

遺伝性腫瘍としての子宮体癌－Lynch症候群との関連

AOKI DAISUKE

産科と婦人科 79 ( 2 ) 143-152 2012.02

Research paper (scientific journal), Joint Work

Identification of mono- and di-sulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer

Shibata TK, Matsumura F, Wang P, Yu S, Chou CC, Khoo KH, Kitayama K, Akama TO, Sugihara K, Kanayama N, Kojima-Aikawa K, Seeberger PH, Fukuda M, Suzuki A, Aoki D, Fukuda MN

J Biol Chem 287 ( 9 ) 6592-6602 2012.02

Research paper (scientific journal), Joint Work

Retrospective study comparing irinotecan and pegylated liposomal doxorubicin in treatment of recurrent platinum-refractory/resistant epithelial ovarian cancer

Nomura H, Tsuda H, Kataoka F, Chiyoda T, Yamagami W, Tominaga E, Susumu N, Aoki D

Eur J Gynaec Oncol 33 ( 1 ) 86-89 2012.01

Research paper (scientific journal), Joint Work

Role of circulating free alu DNA in endometrial cancer

Tanaka H, Tsuda H, Nishimura S, Nomura H, Kataoka F, Chiyoda T, Tanaka K, Iguchi Y, Susumu N, Aoki D

Int J Gynecol Cancer 22 ( 1 ) 82-86 2012.01

Research paper (scientific journal), Joint Work

A new surgical technique of uterine auto-transplantation in cynomolgus monkey: preliminary report about two cases

Kisu I, Mihara M, Banno K, Hara H, Yamamoto T, Araki J, Iida T, Hayashi Y, Moriguchi H, Aoki D

Arch Gynecol Obstet 285 ( 1 ) 129-137 2012.01

Research paper (scientific journal), Joint Work

子宮体がんの現状と将来－予防と治療の観点から－

AOKI DAISUKE

東京都医師会雑誌 65 ( 1 ) 6-10 2012.01

Research paper (scientific journal), Single Work

Narrouw Band Imaging（NBI）システムの婦人科腫瘍への臨床応用

AOKI DAISUKE

産婦人科の実際 61 ( 1 ) 113-118 2012.01

Research paper (scientific journal), Joint Work

若年卵巣胚細胞腫瘍に対する術後化学療法による卵巣機能障害についての検討

AOKI DAISUKE

東京産科婦人科学会会誌 60 ( 4 ) 539-542 2011.12

Research paper (scientific journal), Joint Work

Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer

Masuda K, Banno K, Yanokura M, Kobayashi Y, Kisu I, Ueki A, Ono A, Asahara N, Nomura H, Hirasawa A, Susumu N, Aoki D

Mol Biol Int 2011 256063 2011.12

Research paper (scientific journal), Joint Work

子宮頸がん検診の新たな手法とその導入に際しての考え方

AOKI DAISUKE

日本産科婦人科学会雑誌 63 ( 12 ) 2103-2110 2011.12

Research paper (scientific journal), Single Work

Immunofluorescence-Detected Infiltration of CD4+FOXP3+ Regulatory T Cells Is Relevant to the Prognosis of Patients With Endometrial Cancer

Yamagami W, Susumu N, Tanaka H, Hirasawa A, Banno K, Suzuki N, Tsuda H, Tsukazaki K, Aoki D

Int J Gynecol Cancer 21 ( 9 ) 1628-1634 2011.12

Research paper (scientific journal), Joint Work

Does Severe Anemia Caused by Dose-Dense Paclitaxel-Carboplatin Combination Therapy Have an Effect on the Survival of Patients With Epithelial Ovarian Cancer? Retrospective Analysis of the Japanese Gynecologic Oncology Group 3016 Trial

Kumagai S, Sugiyama T, Shoji T, Michimae H, Katsumata N, Aoki D, Terauchi F, Jobo T, Ochiai K, Yasuda M

Int J Gynecol Cancer 21 ( 9 ) 1585-1591 2011.12

Research paper (scientific journal), Joint Work

Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma

Komiyama S, Aoki D, Saitoh E, Komiyama M, Udagawa Y

Eur J Gynaec Oncol 32 ( 6 ) 611-624 2011.12

Research paper (scientific journal), Joint Work

若年子宮体癌と妊孕性温存療法

AOKI DAISUKE

産婦人科治療 103 ( 6 ) 586-592 2011.12

Research paper (scientific journal), Joint Work

子宮体がんの術後補助療法

AOKI DAISUKE

腫瘍内科 8 ( 6 ) 563-571 2011.12

Research paper (scientific journal), Joint Work

Characterization of novel glycolipid antigens with an α-galactose epitope in lactobacilli detected with rabbit anti-lactobacillus antisera and occurrence of antibodies against them in human sera

Iwamori M, Sakai A, Minamimoto N, Iwamori Y, Tanaka K, Aoki D, Adachi S, Nomura T

J Biochem 150 ( 5 ) 515-523 2011.11

Research paper (scientific journal), Joint Work

Narrow band imaging hysteroscopy: A comparative study using randomized video images

Kisu I, Banno K, Kobayashi Y, Ono A, Masuda K, Ueki A, Nomura H, Hirasawa A, Abe T, Kouyama K, Susumu N, Aoki D

Int J Oncol 39 ( 5 ) 1057-1062 2011.11

Research paper (scientific journal), Joint Work

Uterus autotransplantation in cynomolgus macaques: intraoperative evaluation of uterine blood flow using indocyanine green

Mihara M, Kisu I, Hara H, Iida T, Yamamoto T, Araki J, Hayashi Y, Moriguchi H, Narushima M, Banno K, Suganuma N, Aoki D, Koshima I

Hum Reprod 26 ( 11 ) 3019-3027 2011.11

Research paper (scientific journal), Joint Work

広汎子宮頸部摘出術後妊娠の妊娠・分娩の管理

AOKI DAISUKE

臨床婦人科産科 65 ( 10 ) 1260-1265 2011.10

Research paper (scientific journal), Joint Work

Magnifying hysteroscopy with narrow-band imaging for visualization of endometrial lesions

Kisu I, Banno K, Kobayashi Y, Ono A, Masuda K, Ueki A, Nomura H, Hirasawa A, Abe T, Kouyama K, Susumu N, Aoki D

Int J Gynaecol Obstet 115 ( 1 ) 74-75 2011.10

Research paper (scientific journal), Joint Work

Weekly administration of temsirolimus for heavily pretreated patients with clear cell carcinoma of the ovary: a report of six cases

Takano M, Kikuchi Y, Kudoh K, Goto T, Furuya K, Kikuchi R, Kita T, Fujiwara K, Shiozawa T, Aoki D:

Int J Clin Oncol 16 ( 5 ) 605-609 2011.10

Research paper (scientific journal), Joint Work

miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer

Tsuruta T, Kozaki KI, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J

Cancer Res 71 ( 20 ) 6450-6462 2011.10

Research paper (scientific journal), Joint Work

妊産婦への向精神薬の投与

AOKI DAISUKE

産婦人科治療 103 ( 4 ) 417-421 2011.10

Research paper (scientific journal), Joint Work

MRI検査で診断し、MTX化学療法と子宮動脈塞栓術により子宮温存しえた帝王切開瘢痕部妊娠の1例

AOKI DAISUKE

東京産科婦人科学会会誌 60 ( 3 ) 216-220 2011.09

Research paper (scientific journal), Joint Work

婦人科疾患と遺伝カウンセリング

AOKI DAISUKE

産婦人科の実際 60 ( 9 ) 1331-1338 2011.09

Research paper (scientific journal), Joint Work

遺伝性乳癌・卵巣がんの取扱いとリスク低減卵管卵巣摘出術

AOKI DAISUKE

産科と婦人科 78 ( 9 ) 1064-1068 2011.09

Research paper (scientific journal), Joint Work

白金製剤感受性と抵抗性の再発卵巣癌で、ゲムシタビン+カルボプラチン併用にイニパリブの上乗せを検討

AOKI DAISUKE

新薬と臨床 60 ( 9 ) 192-193 2011.09

Research paper (scientific journal), Single Work

An Adeno-Associated Virus Vector Efficiently and Specifically Transduces Mouse Skeletal Muscle

Murakami I, Takeuchi T, Mori-Uchino M, Mori S, Fujii T, Aoki D, Nakagawa K, Kanda T

Mol Biotechnol 49 ( 1 ) 1-10 2011.09

Research paper (scientific journal), Joint Work

Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: Cytoplasmic sequestration of CDK2 by p27

Itamochi H, Yoshida T, Walker CL, Bartholomeusz C, Aoki D, Ishihara H, Suzuki N, Kigawa J, Terakawa N, Ueno NT

Gynecol Oncol 122 ( 3 ) 641-647 2011.09

Research paper (scientific journal), Joint Work

Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV12

Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H

Am J Pathol 179 ( 3 ) 1471-1482 2011.09

Research paper (scientific journal), Joint Work

遺伝性腫瘍の基礎知識と遺伝子診断および予防法　～遺伝性乳がん・卵巣がんに着目して～．

AOKI DAISUKE

がん看護 16 ( 6 ) 631-635 2011.09

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術におけるneo-cervix形成の工夫

AOKI DAISUKE

産婦人科手術 22 101-105 2011.08

Research paper (scientific journal), Joint Work

子宮頸がんスクリーニング

AOKI DAISUKE

綜合臨床 60 ( 8 ) 1773-1774 2011.08

Research paper (scientific journal), Joint Work

子宮頸部早期浸潤癌に対するradical abdominal trachelectomy後の妊娠転帰

AOKI DAISUKE

日本受精着床学会雑誌 28 ( 2 ) 395-398 2011.08

Research paper (scientific journal), Joint Work

腹腔鏡下子宮筋腫核出術後に5mmトロッカー挿入部より大網が脱出した1例

AOKI DAISUKE

日本産科婦人科内視鏡学会雑誌 27 ( 1 ) 247-250 2011.08

Research paper (scientific journal), Joint Work

いわゆる「マーカー再発」への対応

AOKI DAISUKE

臨床婦人科産科 65 ( 7 ) 919-923 2011.07

Research paper (scientific journal), Joint Work

大腿骨頸部骨密度測定は腰椎骨骨密度測定の代用となり得るか？

AOKI DAISUKE

Osteoporosis Japan 19 ( 3 ) 481-483 2011.07

Research paper (scientific journal), Joint Work

家系内の遺伝子検査が契機となり早期介入を行ったLynch症候群の1例

AOKI DAISUKE

東京産科婦人科学会会誌 60 ( 2 ) 293-297 2011.06

Research paper (scientific journal), Joint Work

子宮移植は可能か？　形成外科と産婦人科の異分野融合研究

AOKI DAISUKE

産婦人科の実際 60 ( 6 ) 899-904 2011.06

Research paper (scientific journal), Joint Work

子宮頸癌をめぐる最近の話題

AOKI DAISUKE

産婦人科治療 102 ( 6 ) 903-909 2011.06

Research paper (scientific journal), Joint Work

再発卵巣がんの薬物療法

AOKI DAISUKE

臨床腫瘍プラクティス 7 ( 2 ) 163-166 2011.05

Research paper (scientific journal), Joint Work

Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer

Nishimura S, Tsuda H, Nomura H, Kataoka F, Chiyoda T, Tanaka H, Tanaka K, Susumu N, Aoki D

Eur J Gynaecol Oncol 32 ( 2 ) 146-149 2011.05

Research paper (scientific journal), Joint Work

The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer

Kataoka F, Tsuda H, Nomura H, Chiyoda T, Tominaga E, Suzuki A, Susumu N, Aoki D

Eur J Gynaecol Oncol 32 ( 2 ) 160-163 2011.05

Research paper (scientific journal), Joint Work

産婦人科臨床における遺伝性乳癌卵巣癌の位置づけ

AOKI DAISUKE

家族性腫瘍 11 ( 2 ) 48-51 2011.05

Research paper (scientific journal), Joint Work

当科「健康維持外来」におけるホルモン補充療法施行症例についての検証

AOKI DAISUKE

日本女性医学学会雑誌 19 ( 1 ) 18-23 2011.05

Research paper (scientific journal), Joint Work

老人性腟炎

AOKI DAISUKE

臨床婦人科産科 65 ( 4（増大号） ) 568-571 2011.04

Research paper (scientific journal), Joint Work

当院における腹式広汎子宮頸部摘出術の経験と工夫

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 29 ( 2 ) 233-237 2011.04

Research paper (scientific journal), Joint Work

子宮頸癌の発癌機構

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 29 ( 2 ) 243-247 2011.04

Research paper (scientific journal), Joint Work

Questionnaire survey of the current status of radical trachelectomy in Japan

Shinya Sato, Daisuke Aoki, Hiroaki Kobayashi, Tsuyoshi Saito, Ryuichiro Nishimura, Tadayoshi Nagano, Nobuo Yaegashi, Takayuki Enomoto, Junzo Kigawa

Int J Clin Oncol 16 ( 2 ) 141-144 2011.04

Research paper (scientific journal), Joint Work

Overexpression of cofilin 1 can predict progression-free survival in patients with epithelial ovarian cancer receiving standard therapy

Nishimura S, Tsuda H, Kataoka F, Arao T, Nomura H, Chiyoda T, Susumu N, Nishio K, Aoki D

Hum Pathol 42 ( 4 ) 516-521 2011.04

Research paper (scientific journal), Joint Work

母体TRAｂ高値に伴う胎児甲状腺機能亢進症に対して抗甲状腺薬による経胎盤的治療を行った1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 60 ( 1 ) 13-17 2011.03

Research paper (scientific journal), Joint Work

子宮頸癌の治療と生殖医療の役割

AOKI DAISUKE

産科と婦人科 78 ( 3 ) 332－336 2011.03

Research paper (scientific journal), Joint Work

Carcinoma of the Lower Uterine Segment (LUS): Clinicopathological Characteristics and Association with Lynch Syndrome

AOKI DAISUKE

Curr Genomics 12 ( 1 ) 25-29 2011.03

Research paper (scientific journal), Joint Work

Flexible hysteroscopy with narrow band imaging (NBI) for endoscopic diagnosis of malignant endometrial lesions

Kisu I, Banno K, Kobayashi Y, Ono A, Masuda K, Ueki A, Nomura H, Hirasawa A, Abe T, Kouyama K, Susumu N, Aoki D

Int J Oncol 38 ( 3 ) 613-618 2011.03

Research paper (scientific journal), Joint Work

A Phase II Clinical Trial of Topotecan in Japanese Patients with Relapsed Ovarian Carcinoma

Daisuke Aoki1, Noriyuki Katsumata, Toru Nakanishi, Junzo Kigawa, Keiichi Fujiwara, Kazuhiro Takehara, Shoji Kamiura, Masamichi Hiura, Masayuki Hatae, Toru Sugiyama, Kazunori Ochiai, Kiichiro Noda

Jpn J Clin Oncol 41 ( 3 ) 320-327 2011.03

Research paper (scientific journal), Joint Work

Randomized phase II study comparing docetaxel plus cisplatin, docetaxel plus carboplatin, and paclitaxel plus carboplatin in patients with advanced or recurrent endometrial carcinoma: a Japanese Gynecologic Oncology Group study (JGOG2041)

Nomura H, Aoki D, Takahashi F, Katsumata N, Watanabe Y, Konishi I, Jobo T, Hatae M, Hiura M, Yaegashi N:

Ann Oncol 22 ( 3 ) 636-642 2011.03

Research paper (scientific journal), Joint Work

子宮頸癌に対する広汎性子宮頸部摘出術

AOKI DAISUKE

産婦人科の実際 60 ( 2 ) 155-160 2011.02

Research paper (scientific journal), Joint Work

A Randomized Phase II/III Trial of 3 Weekly Intraperitoneal versus Intravenous Carboplatin in Combination with Intravenous Weekly Dose-Dense Paclitaxel for Newly Diagnosed Ovarian, Fallopian Tube and Primary Peritoneal Cancer

Fujiwara K, Aotani E, Hamano T, Nagao S, Yoshikawa H, Sugiyama T, Kigawa J, Aoki D, Katsumata N, Takeuchi M, Suzuki M

Jpn J Clin Oncol 41 ( 2 ) 278-282 2011.02

Research paper (scientific journal), Joint Work

腫瘍間質の遺伝子発現解析を用いた進行上皮性卵巣癌に対する新規バイオマーカーの探索

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 26 32-33 2011.01

Research paper (scientific journal), Joint Work

子宮頸がん検診におけるベセスダシステム2001導入に向けた取り組みと課題

AOKI DAISUKE

日本臨床細胞学会雑誌 50 ( 1 ) 1-5 2011.01

Research paper (scientific journal), Joint Work

MicroRNA in endometrial cancer.

Yanokura Megumi, Kouji Banno, Iori Kisu, Kenta Masuda, Arisa Ueki, Yusuke Kobayashi, Kosuke Tsuji, Wataru Yamagami, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

Trends Cancer Res 7 49-55 2011

Research paper (scientific journal), Joint Work

急性腹症にて緊急手術となった悪性卵巣甲状腺腫の1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 59 ( 4 ) 593-597 2010.12

Research paper (scientific journal), Joint Work

子宮内膜癌とエピジェネティクス

AOKI DAISUKE

HORMONE FRONTIER IN GYNECOLOGY 17 ( 4 ) 61-68 2010.12

Research paper (scientific journal), Joint Work

MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)

Megumi Yanokura, Kouji Banno, Yusuke Kobayashi, Iori Kisu, Arisa Ueki, Asuka Ono, Kennta Masuda, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

Oncol Lett 1 ( 6 ) 935-940 2010.11

Research paper (scientific journal), Joint Work

Effects of third-line chemotherapy for women with recurrent ovarian cancer who received platinum/taxane regimens as first-line chemotherapy

Chiyoda T, Tsuda H, Nomura H, Kataoka F, Tominaga E, Suzuki A, Susumu N, Aoki D

Eur J Gynaecol Oncol 31 ( 4 ) 364-368 2010.10

Research paper (scientific journal), Joint Work

飯沼繭，橋本志歩，植木有紗，持丸佳之，古谷正敬，浅田弘法，青木大輔，吉村泰典，安藤正明

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 59 ( 3 ) 428-432 2010.09

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術後の妊孕能

AOKI DAISUKE

産科と婦人科 77 ( 9 ) 1089-1093 2010.09

Research paper (scientific journal), Joint Work

3Ｄ画像は婦人科手術の教育ツールになりえるのか？

AOKI DAISUKE

産科と婦人科 77 ( 9 ) 1044-1049 2010.09

Research paper (scientific journal), Joint Work

無結紮手術（BiClamp，Ligasure，ハーモニック）－広汎子宮全摘出術におけるBiClamp使用の実際

AOKI DAISUKE

産婦人科の実際 59 ( 8 ) 1195－1200 2010.08

Research paper (scientific journal), Joint Work

女性の片頭痛

AOKI DAISUKE

産婦人科治療 101 ( 2 ) 135-139 2010.08

Research paper (scientific journal), Joint Work

A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese

Satoko Uno, Hitoshi Zembutsu, Akira Hirasawa, Atsushi Takahashi, Michiaki Kubo, Tomoko Akahane, Daisuke Aoki, Naoyuki Kamatani, Koichi Hirata, Yusuke Nakamura

Nature Genetics 42 ( 8 ) 707-710 2010.08

Research paper (scientific journal), Joint Work

Amplification of GNAS may be an independent, qualitative, and reproducible biomarker to predict progression-free survival in epithelial ovarian cancer

Ei-ichiro Tominaga, Hiroshi Tsuda, Tokuzo Arao, Sadako Nishimura, Masashi Takano, Fumio Kataoka, Hiroyuki Nomura, Akira Hirasawa, Daisuke Aoki, Kazuto Nishio

Gynecologic Oncology 118 ( 2 ) 160-166 2010.08

Research paper (scientific journal), Joint Work

GAT（癌関連ガラクトース転移酵素）

AOKI DAISUKE

日本臨牀 68 ( 増刊号7 ) 768-771 2010.07

Research paper (scientific journal), Joint Work

CA546，CA602

AOKI DAISUKE

日本臨牀 68 ( 増刊号7 ) 688-690 2010.07

Research paper (scientific journal), Joint Work

閉経前両側卵巣摘出例における骨密度とFRAXの特徴に関する検討

AOKI DAISUKE

Osteoporosis Japan 18 ( 3 ) 461-465 2010.07

Research paper (scientific journal), Joint Work

Relationship between ABCF2 expression and response to chemotherapy or prognosis in clear cell adenocarcinoma of the ovary

Hiroshi Tsuda, Kiyoshi Ito, Nobuo Yaegashi, AkiraHirasawa, Tamotsu Sudo, Tsunekazu Kita, Yoshito Terai, Junzo Kigawa, Toru Sugiyama, Daisuke Aoki

Int J Gynecol Cancer 20 ( 5 ) 794-797 2010.07

Research paper (scientific journal), Joint Work

骨粗鬆症診療における産婦人科医の役割ホルモン補充療法が腰椎骨密度に及ぼす長期的な効果の検討　当科健康維持外来における10年継続投与例からの検証

AOKI DAISUKE

Osteoporosis Japan 18 ( 3 ) 537-539 2010.07

Research paper (scientific journal), Joint Work

妊孕能温存手術を施行してMycoplasma hominisによる膿瘍感染を起こした2例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 59 ( 2 ) 254-259 2010.06

Research paper (scientific journal), Joint Work

Digital Colposcopy for the Diagnosis of Cervical Adenocarcinoma Using a Narrow Band Imaging System

Takuma Fujii, Masaru Nakamura, Kaori Kameyama, Miyuki Saito, Hiroshi Nishio, Akiko Ohno, Nobumaru Hirao, Takashi Iwata, Katsumi Tsukazaki, Daisuke Aoki

International Journal of Gynecological Cancer 20 ( 4 ) 605-610 2010.05

Research paper (scientific journal), Joint Work

月経関連偏頭痛に対する"呉茱萸湯"の周期的投与の試み

AOKI DAISUKE

産婦人科漢方研究のあゆみ ( 27 ) 73-75 2010.04

Research paper (scientific journal), Joint Work

Evidence-based guidelines for treatment of cervical cancer in Japan: Japan Society of Gynecologic Oncology (JSGO) 2007 edition

Satoru Nagase, Yoshiki Inoue, Naohiko Umesaki, Daisuke Aoki, Masatsugu Ueda, Hideki Sakamoto, Shigemitsu Kobayashi, Ryo Kitagawa, Takafumi Toita, Shoji Nagao, Kiyoshi Hasegawa, Ichio Fukasawa, Keiichi Fujiwara, Yoh Watanabe, Kiyoshi Ito, Hitoshi Niikura, Tsuyoshi Iwasaka, Kazunori Ochiai, Hidetaka Katabuchi, Toshiharu Kamura, Ikuo Konishi, Noriaki Sakuragi, Tadao Tanaka, Yasuo Hirai, Yuji Hiramatsu, Makio Mukai, Hiroyuki Yoshikawa, Tadao Takano, Kosuke Yoshinaga, Takeo Otsuki, Michiko Sakuma, Noriyuki Inaba, Yasuhiro Udagawa and Nobuo Yaegashi:

International Journal of Clinical Oncology 15 ( 2 ) 117-124 2010.04

Research paper (scientific journal), Joint Work

Lymph Node Metastasis in Grossly Apparent Stages I and II Epithelial Ovarian Cancer

Hiroyuki Nomura, Hiroshi Tsuda, Nobuyuki Susumu, Takuma Fujii, Kouji Banno, Fumio Kataoka, Eiichiro Tominaga, Atsushi Suzuki, Tatsuyuki Chiyoda, Aoki, Daisuke

International Journal of Gynecological Cancer 20 ( 3 ) 341-345 2010.04

Research paper (scientific journal), Joint Work

卵巣茎捻転

AOKI DAISUKE

産婦人科治療（産婦人科救急のすべて） 100 ( 増刊 ) 342-346 2010.04

Research paper (scientific journal), Joint Work

女性の外陰部の診察

AOKI DAISUKE

臨床泌尿器科 64 ( 4 ) 39-42 2010.04

Research paper (scientific journal), Joint Work

多発巨大子宮筋腫症例への腹腔鏡下子宮全摘術の適応における考察

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 59 ( 1 ) 104-108 2010.03

Research paper (scientific journal), Joint Work

研修会特別講演記録：平成21年度第1回子宮癌検診従事医師及び細胞検査士研修会：子宮頸癌検診－ベセスダシステム導入と精度管理のあり方－

AOKI DAISUKE

日本臨床細胞学会秋田県支部会誌 16 36-40 2010.03

Research paper (scientific journal), Single Work

CIN局所療法の選択とその適応について

AOKI DAISUKE

産婦人科の実際 59 ( 3 ) 473-478 2010.03

Research paper (scientific journal), Joint Work

標準治療を受けた進行上皮性卵巣癌の予後を規定する遺伝子の網羅的検索

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 25 61-62 2010.02

Research paper (scientific journal), Joint Work

卵巣癌初回治療後の再発サーベイランス方法の構築－ガイドライン作成のためのエビデンス作りを目指して－

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 28 ( 2 ) 132-137 2010.02

Research paper (scientific journal), Joint Work

Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas

Sadako Nishimura, Hiroshi Tsuda, Kiyoshi Ito, Masashi Takano, Yoshito Terai, Toshiko Jobo, Junzo Kigawa, Toru Sugiyama, Nobuo Yaegashi, Daisuke Aoki

Int J Gynecol Cancer 20 ( 2 ) 220-226 2010.02

Research paper (scientific journal), Joint Work

Randomized phase II trial of paclitaxel plus carboplatin therapy versus irinotecan plus cisplatin therapy as first-line chemotherapy for clear cell adenocarcinoma of the ovary: a JGOG study

Satoshi Takakura, Masashi Takano, Fumiaki Takahashi, Toshiaki Saito, Daisuke Aoki, Nriyuki Inaba, Kiichiro Noda, Toru Sugiyama, Kazunori Ochiai and on behalf of the Japanese Gynecologic Oncology Group(JGOG)

International Journal of Gynecological Cancer 20 ( 2 ) 240-247 2010.02

Research paper (scientific journal), Joint Work

The sensitivity and specificity of a new formula to distinguish endometrioid type endometrial carcinoma from ovarian endometrial carcinoma

Sadako Nishimura, Yoichi M.Ito, Hiroshi Tsuda, Yoshitaka Ohnishi, Fumio Kataoka, Hiroyuki Nomura, Tatsuyuki Chiyoda, Atsushi Suzuki, Nobuyuki Susumu, Daisuke Aoki, Masayuki Hatae

European Journal of Obstetrics, Gynecology, and Reproductive Biology 148 ( 1 ) 67-72 2010.01

Research paper (scientific journal), Joint Work

術前に粘膜下子宮筋腫と鑑別困難であった子宮腺肉腫の1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 58 ( 4 ) 500-503 2009.12

Research paper (scientific journal), Joint Work

子宮頸がんと妊娠

AOKI DAISUKE

看護技術 55 ( 14 ) 17-20 2009.12

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術の適応と限界

AOKI DAISUKE

臨床産科婦人科 63 ( 12 ) 1495-1499 2009.12

Research paper (scientific journal), Joint Work

Practice pattern for postoperative management of endometrial cancer in Japan: A survey of the Japanese Gynecologic Oncology Group

Yoh Watanabe, Ryo Kitagawa, Daisuke Aoki, Satoshi Takeuchi, Satoru Sagae, Noriaki Sakuragi, Nobuo Yaegashi and Disease Committee of Uterine Endometrial Cancer, Japanese Gynecologic Oncology Group

Gynecologic Oncology 115 ( 3 ) 456-459 2009.12

Research paper (scientific journal), Joint Work

私はこうしている：私の主張　週1回のビスフォスフォネート製剤の投与

AOKI DAISUKE

産婦人科治療 99 ( 5 ) 509-511 2009.11

Research paper (scientific journal), Joint Work

ゲノム薬理学の最近の親展とUGT1A1遺伝子多型診断について

AOKI DAISUKE

産婦人科の実際 58 ( 12 ) 2005-2011 2009.11

Research paper (scientific journal), Joint Work

N-Acetylglucosamine 6-O-sulfotransferase-2 as a tumor marker for uterine cervical and corpus cancer

Akira Seko, Fumio Kataoka, Daisuke Aoki, Masaru Sakamoto, Toshiaki Nakamura, Masayuki Hatae, Suguru Yonezawa, Katsuko Yamashita

Glycoconjugate Journal 26 ( 8 ) 1065-1073 2009.11

Research paper (scientific journal), Joint Work

Epigenetic DNA hypermethylation: Clinical applications in endometrial cancer (Review)

Yuriko Muraki, Kouji Banno, Megumi Yanokura, Yusuke Kobayashi, Makiko Kawaguchi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

Oncology Reports 22 ( 5 ) 967-972 2009.11

Research paper (scientific journal), Joint Work

Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer

Makiko Kawaguchi, Kouji Banno, Megumi Yanokura, Yusuke Kobayashi, Arisa Kishimi, Seiji Ogawa, Iori Kisu, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

International Journal of Oncology 35 ( 5 ) 977-982 2009.11

Research paper (scientific journal), Joint Work

更年期外来受診患者における動脈硬化性疾患の危険因子に関する検討

AOKI DAISUKE

日本更年期医学会雑誌 17 ( 2 ) 171-178 2009.10

Research paper (scientific journal), Joint Work

Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial

Noriyuki Katsumata, Makoto Yasuda, Fumiaki Takahashi, Seiji Isonishi, Toshiko Jobo, Daisuke Aoki, Hiroshi Tsuda, Toru Sugiyama, Shoji Kodama, Eizo Kimura, Kazunori Ochiai, Kiichiro Noda, for the Japanese Gynecologic Oncology Group

Lancet 374 ( 9698 ) 1331-1338 2009.10

Research paper (scientific journal), Joint Work

Abdominal radical trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer in a series of 61 women

Hiroshi Nishio, Takuma Fujii, Kaori Kameyama, Nobuyuki Susumu, Masaru Nakamura, Takashi iwata, Daisuke Aoki

Gynecologic Oncology 115 ( 1 ) 51-55 2009.10

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術の適応と今後の課題

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 58 ( 3 ) 295-296 2009.09

Research paper (scientific journal), Joint Work

選択的子宮動脈塞栓術が奏効した子宮仮性動脈瘤破裂の1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 58 ( 3 ) 346-349 2009.09

Research paper (scientific journal), Joint Work

卵巣腫瘍で腹腔鏡下手術を施行し、境界悪性腫瘍と診断された症例の術前MRI評価について

AOKI DAISUKE

日本産科婦人科内視鏡学会雑誌 25 ( 1 ) 246-251 2009.09

Research paper (scientific journal), Joint Work

子宮傍結合織炎

AOKI DAISUKE

日本臨床（子宮疾患・子宮内膜症の臨床－基礎・臨床研究のアップデート） 67 ( 増刊号5 ) 327-330 2009.08

Research paper (scientific journal), Joint Work

子宮頸上皮内癌

AOKI DAISUKE

日本臨床（子宮疾患・子宮内膜症の臨床－基礎・臨床研究のアップデート） 67 ( 増刊号5 ) 200-205 2009.08

Research paper (scientific journal), Joint Work

子宮頸癌合併妊娠

AOKI DAISUKE

産婦人科の実際 58 ( 7 ) 999-1004 2009.07

Research paper (scientific journal), Joint Work

閉経後骨粗鬆症に対する予防治療を行う際の薬剤選択に関する再検証

AOKI DAISUKE

Osteoporosis Japan 17 ( 3 ) 447-449 2009.07

Research paper (scientific journal), Joint Work

子宮体がん例におけるFRAXを用いた骨折リスク評価

AOKI DAISUKE

Osteoporosis Japan 17 ( 3 ) 492-495 2009.07

Research paper (scientific journal), Joint Work

イリノテカン

AOKI DAISUKE

小児科 50 ( 7 ) 1227-1232 2009.06

Research paper (scientific journal), Joint Work

中高年女性と片頭痛

AOKI DAISUKE

産婦人科治療 98 ( 6 ) 971-975 2009.06

Research paper (scientific journal), Joint Work

Analysis of a correlation between the BRAF V600E mutation and abnormal DNA mismatch repair in patients with sporadic endometrial cancer

Makiko Kawaguchi, Megumi Yanokura, Kouji Banno, Yusuke Kobayashi, Yoshiko Kuwabara, Maya Kobayashi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

International Journal of Oncology 34 ( 6 ) 1541-1547 2009.06

Research paper (scientific journal), Joint Work

子宮がん検診における精度管理充実に向けた追跡調査の取り組みと課題

AOKI DAISUKE

日本がん検診・診断学会誌 17 ( 1 ) 47-51 2009.05

Research paper (scientific journal), Joint Work

Endometrial cancer as HNPCC associated tumor

Kouji Banno, Yusuke Kobayashi, Megumi Yanokura, Arisa Kishimi, Seiji Ogawa, Iori Kisu, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

家族性腫瘍 9 ( 2 ) 64-68 2009.05

Research paper (scientific journal), Joint Work

妊娠と子宮頸部細胞診

AOKI DAISUKE

臨床検査 53 ( 4 ) 429-432 2009.04

Research paper (scientific journal), Joint Work

妊娠を合併した場合の取り扱い

AOKI DAISUKE

産婦人科の実際 58 ( 4 ) 587-592 2009.04

Research paper (scientific journal), Joint Work

1,3-Galactosyltransferases-4/5 are novel tumor markers for gynecological cancers

Akira Seko, Fumio Kataoka, Daisuke Aoki, Masaru Sakamoto, Toshiaki Nakamura, Masayuki Hatae, Suguru Yonezawa, Katsuko Yamashita

Tumour Biology 30 ( 1 ) 43-50 2009.04

Research paper (scientific journal), Joint Work

Endometrial cancer as a familial tumor: pathology and molecular carcinogenesis (review)

Kouji Banno, Megumi Yanokura, Yusuke Kobayashi, Makiko Kawaguchi, Hiroyuki Nomura, Akira Hirasawa, Nobuyuki Susumu, Daisuke Aoki

Current Genomics 10 ( 2 ) 127-132 2009.04

Research paper (scientific journal), Joint Work

骨盤内神経の扱い方－婦人科的立場から－

AOKI DAISUKE

臨床泌尿器科 63 ( 4 ) 67-70 2009.04

Research paper (scientific journal), Joint Work

結合型エストロゲン製剤を用いたホルモン補充療法の腰椎骨密度に対する長期的な効果の検討～当科更年期外来における継続投与10年例の結果から～

AOKI DAISUKE

Osteoporosis Japan 17 ( 2 ) 329-330 2009.04

Research paper (scientific journal), Joint Work

子宮頸部円錐切除術

AOKI DAISUKE

産科と婦人科 76 ( Suppl. 1 ) 217-223 2009.04

Research paper (scientific journal), Joint Work

腹腔鏡手術時期の遅れにより片側卵巣機能障害に至った傍卵巣嚢腫茎捻転の1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 58 ( 1 ) 125-128 2009.03

Research paper (scientific journal), Joint Work

当科更年期外来における更年期不定愁訴に対する漢方薬の使用状況について8年前の調査結果との比較検討

AOKI DAISUKE

産婦人科漢方研究のあゆみ ( 26 ) 44-47 2009.03

Research paper (scientific journal), Joint Work

婦人科がんの妊孕性温存手術　－開腹手術－

AOKI DAISUKE

産婦人科の実際 58 ( 3 ) 291-296 2009.03

Research paper (scientific journal), Joint Work

子宮癌腫瘍マーカーとしてのβ3Gal-T4/T5及びGlcNAc6ST2

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 24 25-26 2009.02

Research paper (scientific journal), Joint Work

卵巣癌治療薬

AOKI DAISUKE

医薬ジャーナル（増刊号新薬展望） 46 ( S-1 ) 175-180 2009.02

Research paper (scientific journal), Joint Work

Overexpression of Class III β-Tubulin Predicts Good Response to Taxane-Based Chemotherapy in Ovarian Clear Cell Adenocarcinoma

Daisuke Aoki, Yoshinao Oda, Satoshi Hattori, Ken-ichi Taguchi, Yoshihiro Ohishi, Yuji Basaki, Shinji Oie, Nao Suzuki, Suminori Kono, Masazumi Tsuneyoshi, Mayumi Ono, Takashi Yanagawa and Michihiko Kuwano

Clin Cancer Research 15 ( 4 ) 1473-1480 2009.02

Research paper (scientific journal), Joint Work

Favourable prognosis with modified dosing of docetaxel and cisplatin in Japanese patients with ovarian cancer

Daisuke Aoki, Yoh Watanabe, Toshiko Jobo, Kimio Ushijima, Kiyoshi Hasegawa, Nobuyuki Susumu, Nao Suzuki, Rui Aoki, Seiji Isonishi, Satoru Sagae, Bunpei Ishizuka, Toshiharu Kamura, Yasuhiro Udagawa, Hiroshi Hoshiai, Yasuo Ohashi, Kazunori Ochiai, Kiichiro Noda

Anticancer Research 29 ( 2 ) 561-566 2009.02

Research paper (scientific journal), Joint Work

成熟嚢胞性奇形腫に腺癌または境界悪性腫瘍を共存した2例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 57 ( 4 ) 451-454 2008.12

Research paper (scientific journal), Joint Work

子宮体癌の術後化学療法－タキサンとプラチナの併用に関する新たなエビデンスの構築を目指して－

AOKI DAISUKE

産婦人科の実際 57 ( 13 ) 2129-2134 2008.12

Research paper (scientific journal), Joint Work

Ancillary testing of liquid-based cytology specimens for identification of patients at high risk of cervical cancer

Takuma Fujii, Miyuki Saito, Takashi Iwata, Nobumaru Hirao, Hiroshi Nishio, Akiko Ohno, Katsumi Tsukazaki, Makio Mukai, Kaori Kameyama, Daisuke Aoki

Virchows Archiv 453 ( 6 ) 545-555 2008.12

Research paper (scientific journal), Joint Work

子宮がん患者へのインフォームドコンセント（IC）

AOKI DAISUKE

臨床腫瘍プラクティス 4 ( 4 ) 313-319 2008.11

Research paper (scientific journal), Joint Work

PhaseⅡClinical Trial of Pegylated Liposomal Doxorubicin(JNS002)in Japanese Patients with Müllerian Carcinoma(Epithelial Ovarian Carcinoma,Primary Carcinoma of Fallopian Tube,Peritoneal Carcinoma)Having a Therapeutic History of Platinum-based Chemotherapy

Noriyuki Katsumata, Yasuhiro Fujiwara, Toshiharu Kamura, Toru Nakanishi, Masayuki Hatae, Daisuke Aoki, Kenichi Tanaka, Hiroshi Tsuda, Shoji Kamiura, Kazuhiro Takehara, Toru Sugiyama, Junzo Kigawa, Keiichi Fujiwara, Kazunori Ochiai, Ryo Ishida, Mitsuo Inagaki, and Kiichiro Noda

Japanese Journal of Clinical Oncology 38 ( 11 ) 777-785 2008.11

Research paper (scientific journal), Joint Work

Can ABCF2 protein expression predict the prognosis of uterine cancer?

S Nishimura, H Tsuda, Y Miyagi, A Hirasawa, A Suzuki, F Kataoka, H Nomura, T Chiyoda, K Banno, T Fujii, N Susumu2, D Aoki

British Journal of Cancer 99 ( 10 ) 1651-1655 2008.11

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術

AOKI DAISUKE

産婦人科の実際 57 ( 11（10月臨時増刊号） ) 1734-1740 2008.10

Research paper (scientific journal), Joint Work

晩期有害事象

AOKI DAISUKE

産婦人科の実際 57 ( 11（10月臨時増刊号） ) 1873-1879 2008.10

Research paper (scientific journal), Joint Work

卵巣癌のリスクファクター

AOKI DAISUKE

臨床婦人科産科 62 ( 10 ) 1282-1289 2008.10

Research paper (scientific journal), Joint Work

更年期外来でのアンケート調査結果からみた本邦の中高年婦人の「night sweats」の実態とホルモン療法の有用性に関する一考察

AOKI DAISUKE

日本更年期医学会雑誌 16 ( 2 ) 246-251 2008.10

Research paper (scientific journal), Joint Work

Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer

Kokichi Sugano, Seigo Nakamura, Jiro Ando, Shin Takayama, Hiroyuki Kamata, Isao Sekiguchi, Megumi Ubukata, Tetsuro Kodama, Masami Arai, Fujio Kasumi, Yasuo Hirai, Tadashi Ikeda, Hiromitsu Jinno, Masaki Kitajima, Daisuke Aoki, Akira Hirasawa, Yuko Takeda, Kumiko Yazaki, Takashi Fukutomi, Takayuki Kinoshita, Ryuichiro Tsunematsu, Teruhiko Yoshida, Masako Izumi, Shino Umezawa, Hiroshi Yagata, Hiroko Komatsu, Naoko Arimori, Noriko Matoba, Nobuhisa Gondo, Shiro Yokoyama, Yoshio Miki

Cancer Science 99 ( 10 ) 1967-1976 2008.10

Research paper (scientific journal), Joint Work

Establishment of an ovarian metastasis model and possible involvement of E-cadherin down-regulation in the metastasis

Yoshiko Kuwabara, Takeo Yamada, Ken Yamazaki, Wen-Lin Du, Kouji Banno, Daisuke Aoki, Michiie Sakamoto

Cancer Science 99 ( 10 ) 1933-1939 2008.10

Research paper (scientific journal), Joint Work

子宮体がん検診のエビデンスとこれからの考え方

AOKI DAISUKE

産婦人科の実際 57 ( 9 ) 1393-1398 2008.09

Research paper (scientific journal), Joint Work

Human monoclonal antibody for ovarian clear cell carcinoma-2, a human monoclonal antibody with antitumor activity against ovarian cancer cells that recognizes CA125-like antigen

Nao Suzuki, Yutaka Tamada, Kimiko Shigihara, Atsushi Suzuki, Nobuyuki Susumu, Isao Ishida, Daisuke Aoki

International Journal of Gynecological Cancer 18 ( 5 ) 996-1006 2008.09

Research paper (scientific journal), Joint Work

知っておきたい子宮頸部細胞診の報告様式－ベセスダシステム2001－

AOKI DAISUKE

日本産科婦人科学会雑誌 60 ( 9 ) N-178-N-184 2008.09

Research paper (scientific journal), Single Work

子宮体がん術後患者における骨密度の特徴に関する検討

AOKI DAISUKE

Osteporosis Japan 16 ( 3 ) 57-59 2008.07

Research paper (scientific journal), Joint Work

子宮頸癌におけるエピジェネティックなＣＨＦＲ遺伝子の不活化とタキサン製剤感受性との関連

AOKI DAISUKE

産婦人科の実際 57 ( 7 ) 1189-1194 2008.07

Research paper (scientific journal), Joint Work

精査により診断に至った重症慢性骨盤痛を伴う異所性子宮内膜症の2例

AOKI DAISUKE

エンドメトリオーシス研究会会誌 29 147-151 2008.07

Research paper (scientific journal), Joint Work

術前に腹腔内貯留液を段階的に除去し卵巣癌根治術を施行した1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 57 ( 2 ) 225-228 2008.06

Research paper (scientific journal), Joint Work

中高年女性とセクシャリティ

AOKI DAISUKE

産婦人科治療 96 ( 6 ) 1030-1034 2008.06

Research paper (scientific journal), Joint Work

Randomized phase III trial of conventional paclitaxel and carboplatin (c-TC) versus dose dense weekly paclitaxel and carboplatin (dd-TC) in women with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer: Japanese Gynecologic Oncology

S. Isonishi, M. Yasuda, F. Takahashi, N. Katsumata, E. Kimura, D. Aoki, T. Jobo, F. Terauchi, H. Tsuda, T. Sugiyama

Jourbal of Clinical Oncology 26 ( 15S ) Abstract No.5506 2008.05

Research paper (scientific journal), Joint Work

再発に対するレジメンとその有効性

AOKI DAISUKE

臨床婦人科産科 62 ( 5 ) 706-711 2008.05

Research paper (scientific journal), Single Work

Randomized phase II study comparing docetaxel plus cisplatin, docetaxel plus carboplatin, and paclitaxel plus carboplatin in patients with advanced or recurrent endometrial carcinoma: Japanese Gynecologic Oncology Group trial (JGOG2041)

H. Nomura, D. Aoki, F. Takahashi, N. Katsumata, Y. Watanabe, I. Konishi, T. Jobo, M. Hatae, M. Hiura, N. Yaegashi, Japanese Gynecologic Oncology Group

Jounal of Clinical Oncology 26 ( 15S ) Abstract No.16526 2008.05

Research paper (scientific journal), Joint Work

術前診断が困難であった双頸・腟中隔を伴う中隔子宮の1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 57 ( 1 ) 21-24 2008.03

Research paper (scientific journal), Joint Work

糖転位酵素を標的とした腫瘍マーカーの開発

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 23 3-4 2008.03

Research paper (scientific journal), Joint Work

ヒトモノクローナル抗体HMMC-1を用いた子宮体癌に対する新規治療法の開発－リンパ行性転移に対する抑制効果を中とした検討－

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 23 62-63 2008.03

Research paper (scientific journal), Joint Work

頸管妊娠に対してMTX全身投与および動脈塞栓術を施行し妊孕能を温存し得た一例

AOKI DAISUKE

日本産科婦人科学会関東連合地方部会誌 45 ( 1 ) 21-26 2008.03

Research paper (scientific journal), Joint Work

子宮頸部微小浸潤腺癌における病理組織学的因子からみた予後解析と治療の個別化の検討

AOKI DAISUKE

日本産科婦人科学会関東連合地方部会誌 45 ( 1 ) 59-65 2008.03

Research paper (scientific journal), Joint Work

A synthetic retinoid, TAC-101 (4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid), plus cisplatin: Potential new therapy for ovarian clear cell adenocarcinoma

Sachiko Ezawa, Nao Suzuki, Shinji Ohie, Atsushi Higashiguchi, Fumihito Hosoi, Kenji Kitazato, Nobuyuki Susumu, Daisuke Aoki

Gynecologic Oncology 108 ( 3 ) 627-631 2008.03

Research paper (scientific journal), Joint Work

がん検診の精度管理の必要性－乳がん検診の精度管理を中心に－

AOKI DAISUKE

日本がん検診・診断学会誌 15 ( 2 ) 104-109 2008.01

Research paper (scientific journal), Joint Work

Induction of trophinin in human endometrial surface epithelia by CGβ and IL-1β

Kazuhiro Sugihara, Maryam Kabir-Salmani, James Byrne, Don P Wolf, Bruce Lessey, Mitsutoshi Iwashita, Daisuke Aoki, Jun Nakayama, Michiko N Fukuda

FEBS Letters 582 ( 2 ) 197-202 2008.01

Research paper (scientific journal), Joint Work

子宮がん検診の動向と問題点

AOKI DAISUKE

東京産婦人科医会誌 40 58-61 2008.01

Research paper (scientific journal), Single Work

子宮頸癌検診と子宮体癌の早期発見のために

AOKI DAISUKE

治療 90 ( 1 ) 110-114 2008.01

Research paper (scientific journal), Joint Work

子宮内膜組織検査後に重症感染症となり子宮摘出を余儀なくされた3症例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 56 ( 4 ) 504-510 2007.12

Research paper (scientific journal), Joint Work

腹腔鏡下に一期的に切除した境界悪性漿液性傍卵巣腫瘍と副腎皮質癌の一例

AOKI DAISUKE

日本産科婦人科内視鏡学会雑誌 23 ( 1 ) 90-95 2007.12

Research paper (scientific journal), Joint Work

子宮体癌

AOKI DAISUKE

臨床雑誌　内科 100 ( 6 ) 1259-1265 2007.12

Research paper (scientific journal), Joint Work

当科における最近5年間の腹腔鏡下の手術の検討

AOKI DAISUKE

日本産科婦人科内視鏡学会雑誌 23 ( 1 ) 233-236 2007.12

Research paper (scientific journal), Joint Work

A novel method for analyzing formalin-fixed paraffin embedded (FFPE) tissue sections by mass spectrometry imaging

Yutaka Aoki, Atsuhiko Toyama, Takashi Shimada, Tetsuyoshi Sugita, Chikage Aoki, Yukari Umino, Atsushi SUZUKI, Daisuke Aoki, Yataro Daigo, Yusuke Nakamura and Taka-Aki Sato

Proceedings of the Japan Academy, Series B 83 ( 7 ) 205-214 2007.11

Research paper (scientific journal), Joint Work

子宮体がんに対する化学療法の最近の動向

AOKI DAISUKE

日本産科婦人科学会雑誌 59 ( 11 ) 1845-1853 2007.11

Research paper (scientific journal), Single Work

Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes

Kouji Banno, Megumi Yanokura, Makiko Kawaguchi, Yoshiko Kuwabara, Jyunko Akiyoshi, Yusuke Kobayashi, Takashi Iwata, Akira Hirasawa, Takuma Fujii, Nobuyuki Susumu, Katsumi Tsukazaki, Daisuke Aoki

International Journal of Oncology 31 ( 4 ) 713-720 2007.10

Research paper (scientific journal), Joint Work

クリニカルレクチャーシリーズ　悪性腺腫：診療上の問題点

AOKI DAISUKE

日本産科婦人科学会雑誌 59 ( 9 ) N-272-N276 2007.09

Research paper (scientific journal), Single Work

Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary

Yutaka Tamada, Hideyuki Takeuchi, Nao Suzuki, Nobuyuki Susumu, Daisuke Aoki, Tatsuro Irimura

Cancer Science 98 ( 10 ) 1586-1591 2007.09

Research paper (scientific journal), Joint Work

卵巣癌・子宮癌

AOKI DAISUKE

コンセンサス癌治療 6 ( 3 ) 150-153 2007.08

Research paper (scientific journal), Joint Work

子宮体がん委員会　−子宮体がん再発高危険群に対する術後化学療法としてのAP（Doxorubicin+Cisplatin）療法，DP（Docetaxel+Cisplatin）療法，TC（Paclitaxel+Carboplatin）療法のランダム化第Ⅲ相試験−

AOKI DAISUKE

第5回婦人科悪性腫瘍化学療法研究機構総会記録集 77-79 2007.08

Research paper (scientific journal), Single Work

子宮体がん委員会　−進行・再発子宮体癌に対するDP（Docetaxel+Cisplatin），DJ（Docetaxel+Carboplatin），TJ（Paclitaxel+Carboplatin）のランダム化第Ⅱ相試験−

AOKI DAISUKE

第5回婦人科悪性腫瘍化学療法研究機構総会記録集 74−76 2007.08

Research paper (scientific journal), Single Work

がん検診の現状と問題点

AOKI DAISUKE

日本臨床胞学会中国四国連合会会報 22 47-50 2007.07

Research paper (scientific journal), Single Work

きれいな手術創を目指した閉腹操作の工夫

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 56 ( 2 ) 141-144 2007.06

Research paper (scientific journal), Joint Work

Expression of NEU3 (plasma membrane-associated sialidase) in clear cell adenocarcinoma of the ovary: its relationship with T factor of pTNM classification

Nomura Hiroyuki, Tamada Yutaka, Miyagi Taeko, Suzuki Atsushi, Taira Momoyo, Suzuki Nao, Susumu Nobuyuki, Irimura Tatsuro, Aoki Daisuk

Oncology Research 16 ( 6 ) 289-297 2007.06

Research paper (scientific journal), Joint Work

Status of surgical treatment procedures for endometrial cancer in Japan: Results of a Japanese Gynecologic Oncology Group Survey

Yoh Watanabe, Daisuke Aoki, Ryo Kitagawa, Satoshi Takeuchi, Satoru Sagae, Noriaki Sakuragi, Nobuo Yaegashi, Disease Committee of Uterine Endometrial Cancer, Japanese Gynecologic Oncology Group

Gynecologic Oncology 105 ( 2 ) 325-328 2007.05

Research paper (scientific journal), Joint Work

卵巣明細胞腺癌におけるシアリダーゼ発現の多寡が腹膜播種形成に及ぼす影響の検討

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 22 39429 2007.04

Research paper (scientific journal), Joint Work

広汎性子宮頸部摘出術（Radical Trachelectomy）

AOKI DAISUKE

産婦人科の実際 56 ( 4 ) 565-569 2007.04

Research paper (scientific journal), Joint Work

研修コーナー：コルポスコピー

AOKI DAISUKE

日本産科婦人科学会雑誌 59 ( 4 ) N-76-N80 2007.04

Research paper (scientific journal), Single Work

Local activation of TGF-beta1 at endometriosis sites

Komiyama Shin-ichi, Aoki Daisuke, Komiyama Mizuka, Nozawa Shiro

The Journal of Reproductive Medicine 52 ( 4 ) 306-312 2007.04

Research paper (scientific journal), Joint Work

A case of pulmonary type of ovarian small cell carcinoma

Suzuki Nao, Kameyama Kaori, Hirao Takeshi, Susumu Nobuyuki, Mukai Makio, Aoki Daisuke

The Journal of Obstetrics and Gynaecology Research 33 ( 2 ) 203-206 2007.04

Research paper (scientific journal), Joint Work

子宮頸がん検診の精度管理

AOKI DAISUKE

日本がん検診・診断学会誌 14 ( 2 ) 137-144 2007.03

Research paper (scientific journal), Joint Work

胎児鏡下胎盤吻合血管レーザー凝固術後に一児胎児死亡となった双胎間輸血症候群（TTTS）の１例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 56 ( 1 ) 88-91 2007.03

Research paper (scientific journal), Joint Work

Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma: A case report

Wataru Yamagami, Kouji Banno, Makiko Kawaguchi, Megumi Yanokura, Yoshiko Kuwabara, Nobumaru Hirao, Nobuyuki Susumu, Katsumi Tsukazaki, Daisuke Aoki

Chemotherapy 53 ( 2 ) 137-141 2007.03

Research paper (scientific journal), Joint Work

Specific expression of hepatocyte nuclear factor-1β in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis

Higashiguchi Atsushi, Yamada Taketo, Susumu Nobuyuki, Mori Taisuke, Suzuki Atsushi, Aoki Daisuke, Sakamoto Michiie

Cancer Science 98 ( 3 ) 387-391 2007.03

Research paper (scientific journal), Joint Work

特集:女性と生活習慣病がん

AOKI DAISUKE

HORMONE FRONTIER IN GYNECOLOGY 14 ( 1 ) 59-64 2007.03

Research paper (scientific journal), Joint Work

Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation

Kazuhiro Sugihara, Daijiro Sugiyama, James Byrne, Don P. Wolf, Kevin P. Lowitz, Yoichi Kobayashi, Maryam Kabir-Salmani, Daita Nadano, Daisuke Aoki, Shiro Nozawa,Jun Nakayama , Tomas Mustelin, Erkki Ruoslahti, Naoto Yamaguchi, Michiko N. Fukuda

Proceedings of the National Academy of Sciences of the United States of America 104 ( 10 ) 3799-3804 2007.03

Research paper (scientific journal), Joint Work

子宮頸癌検診

AOKI DAISUKE

EMBジャーナル 8 ( 2 ) 68-73 2007.02

Research paper (scientific journal), Joint Work

家系内癌集積性を有する子宮体癌症例におけるMMR遺伝子の生殖細胞変異解析

AOKI DAISUKE

家族性腫瘍 7 ( 1 ) 15-18 2007.01

Research paper (scientific journal), Joint Work

Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer.

Yanokura Megumi, Banno Koji, Kawaguchi Makiko, Hirao Nobumaru, Hirasawa Akira, Susumu Nobuyuki, Tsukazaki Katsumi, Aoki Daisuke

Oncology Reports 17 ( 1 ) 41-48 2007.01

Research paper (scientific journal), Joint Work

筋層浸潤の判定にTCRが有用であった子宮腺筋症合併子宮体癌の1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 55 ( 4 ) 391-395 2006.12

Research paper (scientific journal), Joint Work

明細胞腺癌

AOKI DAISUKE

産婦人科の実際 55 ( 13 ) 2185-2193 2006.12

Research paper (scientific journal), Joint Work

Relationship of the aberrant DNA hypermethylation of cancer-related genes with carcinogenesis of endometrial cancer

Banno Koji, Yanokura Megumi, Susumu Nobuyuki, Kawaguchi Makiko, Hirao Nobumaru, Hirasawa Akira, Tsukazaki Katsumi, Aoki Daisuke

Oncology Reports 16 ( 6 ) 1189-1196 2006.12

Research paper (scientific journal), Joint Work

妊娠・授乳期と頭痛−安全な頭痛治療はあるのか？

AOKI DAISUKE

medicina 43 ( 11 ) 1904-1906 2006.11

Research paper (scientific journal), Joint Work

更年期障害と内科疾患のスクリーニング

AOKI DAISUKE

産婦人科の実際 55 ( 11（10月臨時増刊号） ) 1937-1943 2006.10

Research paper (scientific journal), Joint Work

出生前に診断された大動脈弓離断症の一例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 55 ( 3 ) 307-310 2006.09

Research paper (scientific journal), Joint Work

Serum lipoprotein(a) dynamics before/after menopause and long-term effects of hormone replacement therapy on lipoprotein(a) levels in middle-aged and older Japanese women

AOKI DAISUKE

Hormone and metabolic research 38 ( 9 ) 581-586 2006.09

Research paper (scientific journal), Joint Work

Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer

Fujii Takuma, Saito Miyuki, Iwasaki Eri, Ochiya Takahiro, Takei Yoshifumi, Hayashi Shigenori, Ono Akiko, Hirao Nobumaru , Masaru Nakamura, Kaneyuki Kubushiro, Tsukazaki Katsumi, Aoki Daisuke

International Journal of Oncology 29 ( 3 ) 541-548 2006.09

Research paper (scientific journal), Joint Work

研修コーナー：子宮体部漿液性腺癌、明細胞腺癌

AOKI DAISUKE

日本産科婦人科学会雑誌 58 ( 9 ) N260-N267 2006.09

Research paper (scientific journal), Single Work

Proliferative activity of early ovarian clear cell adenocarcinoma depends on association with endometriosis

Komiyama Shin-ichi, Aoki Daisuke, Katsuki Yukio, Nozawa Shiro

European Journal of Obstetrics & Gynecology and Reproductive Biology 127 ( 1 ) 130-136 2006.07

Research paper (scientific journal), Joint Work

UD抜去困難症例に対してresectoscopeによるTCRが有用であった2症例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 55 ( 2 ) 182-186 2006.06

Research paper (scientific journal), Joint Work

Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12

Sakurai Nobuyuki, Miki Yasuhiro, Suzuki Takashi, Watanabe Keiko, Narita Takashi,Ando Kozue, Yung T.M., Aoki Daisuke, Sasano Hironobu, Handa Hiroshi

The Journal of Steroid Biochemistry and Molecular Biology 99 ( 39177 ) 174-181 2006.06

Research paper (scientific journal), Joint Work

Identification of tissue-specific vasculogenic cells originating from murine uterus

Onodera Narumi, Tamaki Tetsuro, Okada Yoshinori, Akatsuka Akira, Aoki Daisuke:

Histochemistry and Cell Biology 125 ( 6 ) 625-635 2006.06

Research paper (scientific journal), Joint Work

ヒトモノクローナル抗体HMMC-1の子宮体癌リンパ節転移に対する効果についての検討

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 21 51-52 2006.05

Research paper (scientific journal), Joint Work

子宮体癌における腫瘍マーカーの意義

AOKI DAISUKE

産婦人科の実際 55 ( 5 ) 753-762 2006.05

Research paper (scientific journal), Joint Work

更年期障害

AOKI DAISUKE

日本臨床　臨床分子内分泌学４　−生殖内分泌系− (大阪・日本臨床社) 64 ( 増刊号4 ) 394-399 2006.04

Research paper (scientific journal), Joint Work

月経前症候群の漢方治療

AOKI DAISUKE

産婦人科治療 92 ( Suppl ) 224-228 2006.04

Research paper (scientific journal), Joint Work

コルポスコピー、コルポ下狙い生検

AOKI DAISUKE

臨床婦人科産科 60 ( 4 ) 369-375 2006.04

Research paper (scientific journal), Joint Work

子宮内膜炎、子宮傍結合織炎

AOKI DAISUKE

臨床婦人科産科 60 ( 4 ) 639-641 2006.04

Research paper (scientific journal), Joint Work

Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer

Nomura Hiroyuki, Aoki Daisuke, Suzuki Nao, Susumu Nobuyuki, Suzuki Atsushi, Tamada Yutaka, Kataoka Fumio, Higashiguchi Atsushi, Ezawa Sachiko, Nozawa Shiro

International Journal of Gynecological Cancer 16 ( 2 ) 799-804 2006.03

Research paper (scientific journal), Joint Work

卵管妊娠に対する腹腔鏡下手術による保存的治療の問題点とその対策

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 55 ( 1 ) 39-43 2006.03

Research paper (scientific journal), Joint Work

細胞診による子宮頸がん

AOKI DAISUKE

綜合臨床 55 ( 3 ) 460-465 2006.03

Research paper (scientific journal), Joint Work

Hypermethylation in the p16 promoter region in the carcinogenesis of endometrial cancer in Japanese patients

Yanokura Megumi, Banno Kouji, Susumu Nobuyuki, Kawaguchi Makiko, Kuwabara Yoshiko, Tsukazaki Katsumi, Aoki Daisuke

Anticancer Research 26 ( 2A ) 851-856 2006.03

Research paper (scientific journal), Joint Work

表層上皮性・間質性腫瘍の腫瘍マーカー

AOKI DAISUKE

病理と臨床 24 ( 2 ) 140-145 2006.02

Research paper (scientific journal), Joint Work

Lactation and Risk of Endometrial Cancer in Japan: A Case-Control Study

Okamura Chikako, Tsubono Yoshitaka, Ito Kiyoshi, Niikura Hitoshi, Takano Tadao, Nagase Satoru, Yoshinaga Kohsuke, Terada Yukihiro, Murakami Takashi, Sato Shinji, Aoki Daisuke, Jobo Toshiko, Okamura Kunihiro, Nobuo Yaegashi

The Tohoku Journal of Experimental Medicine 208 ( 2 ) 109-115 2006.02

Research paper (scientific journal), Joint Work

8-1A, a human monoclonal antibody that reacts with intact human chorionic gonadotropin

Suzuki Nao, Aoki Daisuke, Orikawa Kimiko, Suzuki Atsushi, Susumu Nobuyuki, Tamada Yutaka, Sakayori Motoko, Tsukazaki Katsumi, Mukai,Makio Kikuchi H, Ishida Isao, Nozawa Shiro

Placenta 27 ( 39116 ) 333-339 2006.02

Research paper (scientific journal), Joint Work

Sensitivity to cisplatin determined by the histoculture drug response assay and clinical response of endometrial cancer

Kanasugi Masaru, Aoki Daisuke, Suzuki Nao, Susumu Nobuyuki, Nakata Sakura, Horiuchi Miwa, Udagawa Yasuhiro, Nozawa Shiro

International Journal of Gynecological Cancer 16 ( 1 ) 409-415 2006.01

Research paper (scientific journal), Joint Work

術前画像検査にて悪性が疑われたadenomyotic cystの1例

AOKI DAISUKE

日本産科婦人科学会東京地方部会会誌 54 ( 4 ) 579-582 2005.12

Research paper (scientific journal), Joint Work

Establishment and characterization of the RMG-V cell line from human ovarian clear cell adenocarcinoma

Aoki Daisuke, Suzuki Nao, Susumu Nobuyuki, Noda Tomomi, Suzuki Atsushi, Tamada Yutaka, Higashiguchi Atsushi, Oie Shinji, and Nozawa Shiro

Human Cell 18 ( 3 ) 143-146 2005.12

Research paper (scientific journal), Joint Work

Loss of integrin α3 expression is associated with acquisition of invasive potential by ovarian clear cell adenocarcinoma cells

Suzuki Nao, Higashiguchi Atsushi, Hasegawa Yuko, Matsumoto Hiroshi, Oie Shinji, Orikawa Kimiko, Ezawa Sachiko, Susumu Nobuyuki, Miyashita Ki-ichi, Aoki Daisuke

Human Cell 18 ( 3 ) 147-155 2005.12

Research paper (scientific journal), Joint Work

Intermittent pneumatic compression for prevention of pulmonary thromboembolism after gynecologic surgery

Suzuki Nao, Kataoka Fumio, Higashiguchi Atsushi, Hirao Takeshi, Ezawa Sachiko, Nomura Hiroyuki, Tomita Akiyo, Susumu Nobuyuki, Aoki Daisuke

Thrombosis Journal 3 18p 2005.11

Research paper (scientific journal), Joint Work

Paraneoplastic cerebellar degeneration with fallopian tube adenocarcinoma

Tanaka Yudai, Suzuki Nao, Takao Masaki, Ichikawa Akiko, Susumu Nobuyuki, Aoki Daisuke

Gynecologic Oncology 99 ( 2 ) 500-503 2005.11

Research paper (scientific journal), Joint Work

婦人科領域における迅速病理診断の正診性について

AOKI DAISUKE

日本婦人科腫瘍学会雑誌 23 ( 4 ) 543-550 2005.10

Research paper (scientific journal), Joint Work

Clinicopathologic manifestations of early-onset endometrial cancer in Japanese women with a familial predisposition to cancer

Yamagami Wataru, Susumu Nobuyuki, Banno Kouji, Hirao Takeshi, Kataoka Fumio, Hirasawa Akira, Suzuki Nao, Aoki Daisuke, Nozawa Shiro

The Journal of Obstetrics and Gynaecology Research 31 ( 5 ) 444-451 2005.10

Research paper (scientific journal), Joint Work

Phase II trial of docetaxel in advanced or metastatic endometrial cancer: a Japanese Cooperative Study

Katsumata Noriyuki, Noda Kiichiro, Nozawa Shiro, Kitagawa Ryo, Nishimura Ryuichiro, Yamaguchi Satoshi, Aoki Daisuke, Susumu Nobuyuki, Kuramoto Hiroyuki, Jobo Toshiko, Ueki Ken, Ueki Minoru, Kohno Ichiro, Fujiwara Keiichi, Sohda Yasuhito, Fuyuki Eguchi

British journal of cancer 93 ( 9 ) 999-1004 2005.10

Research paper (scientific journal), Joint Work

実地臨床応用が期待される新たな腫瘍マーカー−バイオマーカーとしてのゲノム変化を中心に−

AOKI DAISUKE

臨床婦人科産科 59 ( 10 ) 1383-1387 2005.10

Research paper (scientific journal), Joint Work

当院で行っているabdominal radical trachelectomy

AOKI DAISUKE

産婦人科の実際 54 ( 10 ) 1651-1656 2005.10

Research paper (scientific journal), Joint Work

わが国の臨床研究グループの現状と今後の進む道関東婦人科腫瘍研究機構　−JKTBならびにJCGOGにおける臨床試験−

AOKI DAISUKE

産科と婦人科 72 ( 9 ) 1133-1139 2005.09

Research paper (scientific journal), Joint Work

卵巣癌における腫瘍マーカーの使い方

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 20 98-99 2005.08

Research paper (scientific journal), Joint Work

マイクロサテライト不安定性（MSI）を示す子宮体癌の臨床病理学的特徴

AOKI DAISUKE

日本分子腫瘍マーカー研究会誌 20 65-66 2005.08

Research paper (scientific journal), Joint Work

婦人科領域手術後に合併する肺血栓塞栓症の発症に寄与する危険因子の検討

AOKI DAISUKE

産婦人科の実際 54 ( 6 ) 887-892 2005.06

Research paper (scientific journal), Joint Work

特集女性医療と漢方頭痛

AOKI DAISUKE

漢方と最新治療 14 ( 2 ) 119-124 2005.05

Research paper (scientific journal), Joint Work

Chemosensitivity testing of ovarian cancer using the histoculture drug response assay: sensitivity to cisplatin and clinical response.

Nakada Sakura, Aoki Daisuke, Ohie Shinji, Horiuchi Miwa, Suzuki Nao, Kanasugi Masaru, Susumu Nobuyuki, Udagawa Yasuhiro, Nozawa Shiro

International Journal of Gynecological Cancer 15 ( 3 ) 445-452 2005.05

Research paper (scientific journal), Joint Work

婦人科腫瘍における予後因子と治療効果予測因子

AOKI DAISUKE

Biotherapy 19 ( 3 ) 263-271 2005.05

Research paper (scientific journal), Joint Work

婦人科腫瘍

AOKI DAISUKE

癌と化学療法 32 ( 33 ) 411-416 2005.03

Research paper (scientific journal), Joint Work

婦人科疾患術後に発症した肺血栓塞栓症における危険因子の検討

AOKI DAISUKE

日本産婦人科・新生児血液学会誌 14 ( 2 ) 62-67 2005.03

Research paper (scientific journal), Joint Work

Clinical characteristics of prognostic factors in poorly differentiated (G3) endometrioid adenocarcinoma in Japan

Kuwabara Yoshiko, Susumu Nobuyuki, Banno Kouji., Hirao Takeshi, Kawaguchi Makik, Yamagami Wataru, Suzuki Nao, Aoki Daisuke, Nozawa Shiro

Jpn. J. Clin. Oncol. 35 ( 1 ) 23-27 2005.01

Research paper (scientific journal), Joint Work

Efficient screening for ovarian cancers using a combination of tumor markers CA602 and CA546

Saito Miwa, Aoki Daisuke,Susumu Nobuyuki,Suzuki Atsushi, Suzuki Nao,Udagawa Yasuhiro,Nozawa Shiro

International Journal of Gynecological Cancer 15 ( 1 ) 37-44 2005.01

Research paper (scientific journal), Joint Work

Diagnostic clinical application of two-color fluorescence in situ hybridization that detects chromosome 1 and 17 alterations to direct touch smear and liquid-based thin-layer cytologic preparations of endometrial cancers

Susumu Nobuyuki, Aoki Daisuke, Noda Tomomi, Nagashima Yoshio, Hirao Takeshi, Tamada Yutaka, Banno Kouji, Suzuki Atsushi, Suzuki Nao, Tsuda Hitoshi, Inazawa Johji, Nozawa Shiro

International Journal of Gynecological Cancer 15 ( 1 ) 70-80 2005.01

Research paper (scientific journal), Joint Work

子宮頸がん検診の現状と問題点

AOKI DAISUKE

栃木県産婦人科医報 31 ( 2 ) 218-222 2005

Research paper (scientific journal), Single Work

HMOCC-1, a human monoclonal antibody that inhibits adhesion of ovarian cancer cells to human mesothelial cells

Nao Suzuki, Daisuke Aoki, Yutaka Tamada, Nobuyuki Susumu, Kimiko Orikawa, Katsumi Tsukazaki, Motoko Sakayori, Atsushi Suzuki, Takeshi Fukuchi, Makio Mukai, Kyoko Kojima-Aikawa, Isao Ishida and Shiro Nozawa

Gynecologic Oncology 95 ( 2 ) 290-298 2004.11

Research paper (scientific journal), Joint Work

子宮体癌の治療　保存的療法としてのホルモン療法

進伸幸，　青木大輔，　玉田裕，　阪埜浩司，　鈴木淳，　鈴木直，　野澤志朗

日本臨床 62 ( 増刊 ) 375-380 2004.10

Research paper (scientific journal), Joint Work

HMMC-1: a humanized monoclonal antibody with therapeutic potential against mulerian duct-related carcinomas

Nozawa Shiro, Aoki Daisuke, Tsukazaki Katsumi, Susumu Nobuyuki, Sakayori Motoko, Suzuki Nao, Suzuki Atsushi, Wakita Rie, Mukai Makio, Egami Yuko, Kojima-Aikawa Kyoko, Ishida Isao, Belot Frederic, Hindsgaul Ole, Fukuda Minoru and Fukuda Michiko N.

Clinical Cancer Research 10 ( 20 ) 7071-7078 2004.10

Research paper (scientific journal), Joint Work

子宮体癌の治療　治療概論

青木大輔，　平沢晃，　進伸幸，　野澤志朗

日本臨床 62 ( 増刊 ) 324-328 2004.10

Research paper (scientific journal), Joint Work

卵巣癌の診断　腫瘍マーカー

青木大輔，　片岡史夫，　進伸幸，　野澤志朗

日本臨床 62 ( 増刊 ) 496-502 2004.10

Research paper (scientific journal), Joint Work

体がん委員会進行・再発子宮体癌に対するDP（Docetaxel+Cisplatin），DJ（Docetaxel+Carboplatin），TJ（Paclitaxel+Carboplatin）のランダム化第??相試験

AOKI DAISUKE

第2回婦人科悪性腫瘍化学療法研究機構総会記録集 30-35 2004.09

Research paper (other academic), Single Work

A novel retinoid, 4-[3,5-bis (trimethylsilyl) benzamido] benzoic acid (TAC-101), induces apoptosis of human ovarian carcinoma cells and shows potential as a new antitumor agent for clear cell adenocarcinoma

Suzuki Nao, Aoki Daisuke, Oie Shinji, Horiuchi Miwa, Hasegawa Yuko, Ezawa Sachiko, Suzuki Atsushi, Susumu Nobuyuki, Hosoi Fumihito, Kitazato Kenji, Nozawa Shiro

Gynecologic Oncology 94 ( 3 ) 643-649 2004.09

Research paper (scientific journal), Joint Work

Association of HNPCC and endometrial cancers

Banno Kouji, Susumu Nobuyuki, Yanokura Megumi, Hirao Takeshi, Iwata Takashi, Hirasawa Akira, Aoki Daisuke, Sugano Kokichi, Nozawa Shiro

International Journal of Clinical Oncology 9 ( 4 ) 262-269 2004.08

Research paper (scientific journal), Joint Work

Two Japanese kindreds occurring endometrial cancer meeting new clinical criteria for hereditary non-polyposis colorectal cancer (HNPCC), Amsterdam Criteria II

Banno Kouji, Susumu Nobuyuki, Hirao Takeshi, Yanokura Megumi, Hirasawa Akira, Aoki Daisuke, Udagawa Yasuhiro, Sugano Kokichi, Nozawa Shiro

Journal of Obstetrics and Gynecology Research 30 ( 4 ) 287-292 2004.08

Research paper (scientific journal), Joint Work

閉経後ホルモン療法と尿失禁発生リスク

AOKI DAISUKE

HAP（Health Aging Projects for Women） 2004.07

Research paper (other academic), Single Work

卵巣腫瘍

青木大輔，　斎藤英子，　鈴木直，　進伸幸，　野澤志朗

診断と治療 92 ( 増刊 ) 487-495 2004.04

Research paper (scientific journal), Joint Work

婦人科学

野澤志朗，玉田　裕，青木大輔，鈴木　淳，久布白兼行

日本醫事新報 ( 4167 ) 37-43 2004.03

Research paper (scientific journal), Joint Work

婦人科領域の腫瘍マーカー

野澤志朗，青木大輔，片岡史夫

日本医師会雑誌 131 ( 5 ) 644-650 2004.03

Research paper (scientific journal), Joint Work

子宮体癌に対する新たな治療戦略

平沢　晃，青木大輔，野澤志朗

産科と婦人科 71 ( 2 ) 201-207 2004.02

Research paper (scientific journal), Joint Work

子宮頸がんの最近の動向と検診の問題点

青木大輔

日本臨床細胞学会秋田県支部会誌 ( 10 ) 47-55 2004.01

Research paper (scientific journal), Single Work

Model for paraaortic lymph node metastasis produced by orthotopic implantation of ovarian carcinoma cells in athymic nude mice

Tamada Yutaka， Aoki Daisuke， Nozawa Shiro，　Irimura Tatsuro

European Journal of Cancer 40 ( 1 ) 158-163 2004.01

Research paper (scientific journal), Joint Work

Muller管関連腫瘍に対するヒトモノクロナール抗体の作製と認識抗原の検討

青木大輔，進　伸幸，酒依元子，鈴木　淳，鈴木　直，塚崎克己，　向井萬起男，　相川京子，　石田　功，野澤志朗

日本分子腫瘍マーカー研究会誌 19 51-52 2003.12

Research paper (scientific journal), Joint Work

Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnanciesPossible role of human chorionic gonadotrophin on ectopic pregnancy

Nakayama Jun， Aoki Daisuke，　Suga Tomoaki，　Akama Tomoya O.，　Ishizone Satoshi，　Yamaguchi Hirohito，　Imakawa Kazuhiro，　Nadano Daita，　Fazleabas Asgerally T.，　Katsuyama Tsutomu， Nozawa Shiro，　Fukuda Michiko N.

American Journal of Pathology 163 ( 6 ) 2211-2219 2003.12

Research paper (scientific journal), Joint Work

婦人科悪性疾患

青木大輔，鈴木　直，進　伸幸，野澤志朗

Perinatal Care 22 ( 11 ) 13-20 2003.11

Research paper (scientific journal), Joint Work

Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer

Hirasawa Akira， Aoki Daisuke，　Inoue Jun，　Imoto Issei， Susumu Nobuyuki，　Sugano Kokichi， Nozawa Shiro，　Inazawa Johji

Clinical Cancer Research 9 ( 15 ) 5675-5682 2003.11

Research paper (scientific journal), Joint Work

卵巣癌細胞に対するヒトモノクロナール抗体HMOCC-1の作製とその治療への応用の可能性

鈴木　直，青木大輔，進　伸幸，塚崎克己，鈴木　淳，酒依元子，折川公子，野澤志朗

日本婦人科腫瘍学会雑誌 21 ( 4 ) 288-289 2003.10

Research paper (scientific journal), Joint Work

Identification of germline MSH2gene mutations in endometrial cancer not fulfilling the new clinical criteria for hereditary nonpolyposis colorectal cancer

Banno Kouji， Susumu Nobuyuki， Hirao Takeshi， Yanokura Megumi， Hirasawa Akira， Aoki Daisuke，　Udagawa Yasuhiro，　Sugano Kokichi， Nozawa Shiro

Cancer Genetics and Cytoqenetics 146 ( 1 ) 58-65 2003.10

Research paper (scientific journal), Joint Work

卵巣癌診断における腫瘍マーカーの組み合わせ

青木大輔，片岡史夫，野澤志朗

産婦人科の世界 52 ( 9 ) 1257-1265 2003.09

Research paper (scientific journal), Joint Work

横隔膜直下まで発育した巨大子宮筋腫の一例

有賀まどか，進　伸幸，田中雄大，鶴田智彦，青木大輔，吉村泰典，野澤志朗，　向井萬起男

日本産科婦人科学会東京地方部会会誌 52 ( 3 ) 356-360 2003.09

Research paper (scientific journal), Joint Work

卵巣癌診断における腫瘍マーカーの組合せ

青木大輔，片岡史夫，野澤志朗

産婦人科の実際 52 ( 9 ) 1257-1265 2003.09

Research paper (scientific journal), Joint Work

遺伝性子宮内膜癌とは−特にDNAミスマッチ修復遺伝子について

阪埜浩司，進　伸幸，矢野倉恵，平尾　健，岩田　卓，平沢　晃，青木大輔，野澤志朗

産婦人科の世界 55 ( 8 ) 863-870 2003.08

Research paper (scientific journal), Joint Work

Galactosyltransferase associated with tumor in patients with ovarian cancer:Factors involved in elevation of serum galactosyltransferase

Saitoh Eiko， Aoki Daisuke， Susumu Nobuyuki，　Udagawa Yasuhiro， Nozawa Shiro

International Journal of Oncology 23 ( 2 ) 303-310 2003.08

Research paper (scientific journal), Joint Work

Subcellular localization of galactosyltransferase associated with tumors in endometrial and ovarian cancer cells

Susumu Nobuyuki，　Kawakami Hayato， Aoki Daisuke， Suzuki Nao， Suzuki Atsushi，　Uejima Takao，　Hirano Hiroshi， Nozawa Shiro

ACTA HISTOCHEMICA ET CYTOCHEMICA 36 ( 3 ) 205-214 2003.08

Research paper (scientific journal), Joint Work

がん検診の有用性とその評価方法

青木大輔

日本産科婦人科学会雑誌 55 ( 8 ) 952-958 2003.08

Research paper (scientific journal), Single Work

Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets¹

Hirasawa Akira，　Saito-Ohara Fumiko，　Inoue Jun， Aoki Daisuke， Susumu Nobuyuki，　Yokoyama Tetsuji， Nozawa Shiro，　Inazawa Johji，　Imoto Issei

Clinical Cancer Research 9 1995-2004 2003.06

Research paper (scientific journal), Joint Work

HNPCCの診療と研究遺伝性非腺腫症性大腸癌(HNPCC)と子宮内膜癌

阪埜浩司，進　伸幸，平尾　健，岩田　卓，平沢　晃，青木大輔，野澤志朗

家族性腫瘍 3 ( 2 ) 62-67 2003.05

Research paper (scientific journal), Joint Work

がん臨床研究の目指すところ

青木大輔

学術の動向 8 ( 4 ) 60-61 2003.04

Research paper (scientific journal), Single Work

当院で経験した子宮頸部小細胞癌10例の検討

Oono Akiko, Susumu Nobuyuki, Hirao Nobumaru, Fukuchi Takeshi, Fujii Takuma, Kubushiro Kaneyuki, Aoki Daisuke, Tsukazaki Katsumi, Yoshimura Yasunori, Nozawa Shirou, Mukai Makio

日本産科婦人科学会東京地方部会会誌 52 ( 1 ) 71-75 2003.03

Research paper (scientific journal), Joint Work

卵巣腫瘍術後に判明した4型胃癌に対しTS-1，少量CDDP併用化学療法が奏効した1症例

Akiba Yasutada, Watanabe Chikako, Takada Yasuhiro, Naitou Koutarou, Aoki Daisuke, Mukai Makio, Hibi Toshifumi, Ishii Hiromasa

癌と化学療法 30 ( 2 ) 277-281 2003.02

Research paper (scientific journal), Joint Work

Primary carcinosarcoma of the vagina

Shibata Rie, Umezawa Akihiro, Takehara Kyoko, Aoki Daisuke, Nozawa S, Hata Junichi

Pathology international 52 ( 3 ) 204-213 2003.02

Research paper (scientific journal), Joint Work

Primary carcinosarcoma of the vagina

Shibata Rie, Umezawa Akihiro, Takehara Kyoko, Aoki Daisuke, Nozawa Shiro, Hata Jun-ichi

Pathology international 53 ( 2 ) 106-110 2003.02

Research paper (scientific journal), Joint Work

卵巣腫瘍術後に判明した4型胃癌に対しTS-1，少量CDDP併用化学療法が奏効した1症例

Akiba Yasutada, Watanabe Chikako, Takada Yasuhiro, Naitou Koutarou, Aoki Daisuke, Mukai Makio, Katou Shinzou, Hibi Toshifumi, Ishii Hiromasa

癌と化学療法 30 ( 2 ) 277-281 2003.02

Research paper (scientific journal), Joint Work

Primary carcinosarcoma of the vagina

Shibata Rie，　Umezawa Akihiro， Takehara Kyoko， Aoki Daisuke， Nozawa Shiro，　Hata Jun-ichi

Pathology International 53 ( 2 ) 106-110 2003.02

Research paper (scientific journal), Joint Work

細胞診液状検体を用いた細胞診標本の診断的有用性とHPV-DNA検出・型判定に関する検討

藤井多久磨，舛本暢生，石川光也，福地剛，齋藤深雪，久布白兼行，青木大輔，塚崎克己，野澤志朗

日本がん検診・診断学会誌 10 ( 2 ) 55-58 2003.01

Research paper (scientific journal), Joint Work

婦人科がんの遺伝子検査—新しい検査法の可能性—

Aoki Daisuke, Saitou Eiko, Suzuki Nao, Nozawa Shirou

臨床婦人科産科 57 ( 1 ) 30-33 2003.01

Research paper (scientific journal), Joint Work

子宮体癌の治療法

Susumu Nobuyuki, Aoki Daisuke, Kanasugi Masaru, Hirao Takeshi, Banno Kouji, Suzuki Nao, Nozawa Shirou

産婦人科治療 85 ( 6 ) 649-660 2002.12

Research paper (scientific journal), Joint Work

子宮体部悪性腫瘍

Aoki Daisuke, Kataoka Fumio, Susumu Nobuyuki, Nozawa Shirou

産婦人科の世界 54 ( 12 ) 45-54 2002.12

Research paper (scientific journal), Joint Work

子宮体癌における傍大動脈リンパ節廓清後の長期予後について　子宮体癌における傍大動脈リンパ節廓清の意義

Susumu Nobuyuki, Aoki Daisuke, Nomura Hiroyuki, Banno Kouji, Suzuki Nao, Nozawa Shirou

日本婦人科腫瘍学会雑誌 20 ( 4 ) 470-470 2002.10

Research paper (scientific journal), Joint Work

完全ヒト型抗体産生マウスを用いt子宮体癌に対するヒト型モノクロナール抗体の作製

Nozawa Shirou, Aoki Daisuke, Tsukazaki Katsumi, Susumu Nobuyuki, Sakayori Motoko, Wakita Rie, Mukai Makio, Aikawa Kyouko, Ishida Isao

日本分子腫瘍マーカー研究会誌 18 18-19 2002.10

Research paper (scientific journal), Joint Work

婦人科癌とDNAミスマッチ修復遺伝子―HNPCCに関する婦人科癌を中心として―

Aoki Daisuke, Hirasawa Akira, Susumu Nobuyuki, Nozawa Shirou

産婦人科の実際 51 ( 10 ) 1361-1368 2002.10

Research paper (scientific journal), Joint Work

子宮腺筋症から発生したと考えられた子宮体癌の2症例

Nakamura Masaru, Susumu Nobuyuki, Higashiguchi Atsushi, Ueno Kazunori, Uehara Katsuhiko, Aoki Daisuke, Yoshimura Yasunori, Nozawa Shirou

日本産科婦人科学会東京地方部会会誌 51 ( 3 ) 329-333 2002.09

Research paper (scientific journal), Joint Work

卵巣癌における細胞表面結合ヒアルロン酸の役割

Tamada Yutaka, Aoki Daisuke, Nozawa Shirou, Irimura Tatsurou

日本分子腫瘍マーカー研究会誌 17 ( 1 ) 66-67 2002.09

Research paper (scientific journal), Joint Work

卵巣癌の初回治療後の経過観察ならびに地固め療法(consolidation chemotherapy)の必要性

Susumu Nobuyuki, Aoki Daisuke, Kataoka Fumio, Suzuki Nao, Nozawa Shirou

産婦人科の実際 51 ( 9 ) 1209-1217 2002.09

Research paper (scientific journal), Joint Work

腫瘍マーカーによる子宮体癌診断の要点

Aoki Daisuke, Kataoka Fumio, Susumu Nobuyuki, Nozawa Shirou

産婦人科の実際 51 ( 7 ) 949-957 2002.07

Research paper (scientific journal), Joint Work

子宮体癌の化学療法

Susumu Nobuyuki, Aoki Daisuke, Suzuki Nao, Nozawa Shirou

産科と婦人科 69 ( 5 ) 595-603 2002.05

Research paper (scientific journal), Joint Work

大網切除におけるハーモニック・スカルペルの使用経験

Suzuki Nao, Aoki Daisuke, Naitou Emi, Higashiguchi Atsushi, Kataoka Fumio, Kanasugi Masaru, Setou Eri, Susumu Nobuyuki, Nozawa Shirou

産婦人科手術 ( 13 ) 173-173 2002.04

Research paper (scientific journal), Joint Work

Significance of plasminogen activator inhibitor-1(PAI-1) expression in ovarian clear cell adenocarcinoma

Komiyama Shin-ichi, Aoki Daisuke, Susumu Nobuyuki, Suzuki Nao, Kataoka Fumio, Higashiguchi Atsushi, Nozawa Shiro

Acta histochemica et cytochemica 35 ( 2 ) 143-143 2002.04

Research paper (scientific journal), Joint Work

Effectiveness of mass screening for endometrial cancer

Nakagawa-Okamura Chikako, Sato Shinji, Tsuji Ichiro, Kuramoto Hiroyuki, Tsubono Yoshitake, Aoki Daisuke, Jobo Toshiko, Oomura Mineo, Hisamichi Shigeru, Yajima Akira

Acta Cytologica 46 ( 2 ) 277-283 2002.03

Research paper (scientific journal), Joint Work

Significance of MUC1 mucin expression in clear cell adenocarcinoma of the ovary

Tamada Yutaka, Aoki Daisuke, Suzuki Nao, Susumu Nobuyuki, Irimura Tatsuro, Nozawa Shiro

Acta Histochemica et Cytochemica 35 ( 1 ) 48-48 2002.03

Research paper (scientific journal), Joint Work

Application of two-color FISH with liquid-based thin-layer cytologic preparations for uterine adenocarcinomas

Susumu Nobuyuki, Aoki Daisuke, Suzuki Nao, Nozawa Shiro

Acta Histochemica et Cytochemica 35 ( 1 ) 44-44 2002.03

Research paper (scientific journal), Joint Work

当院における原発性卵管癌10例の臨床病理学的検討

Higashiguchi Atsushi，Susumu Nobuyuki，Naitou Emi，Kataoka Fumio，Ishikawa Mitsuya，Ogawa Mariko，Yanamoto Shigehisa，Suzuki Nao，Fujii Takuma，Aoki Daisuke，Yoshimura Yasunori，Nozawa Shirou

日本産科婦人科学会東京地方部会会誌 51 ( 1 ) 139-143 2002.03

Research paper (scientific journal), Joint Work

子宮体癌に対する手術療法

Susumu Nobuyuki，Aoki Daisuke，Kanasugi Masaru，Hirasawa Akira，Suzuki Nao，Nozawa Shirou

日本婦人科腫瘍学会雑誌 20 ( 1 ) 26-32 2002.02

Research paper (scientific journal), Joint Work

Primary carcinosarcoma of the vagina

Shibata Rie, Umezawa Akihiro, Takehara Kyoko, Aoki Daisuke, Nozawa Shiro, Hata Jun-ichi

Patology international 53 ( 2 ) 106-110 2002.02

Research paper (scientific journal), Joint Work

腫瘍マーカーの読み方の実際―卵巣癌・子宮癌

Suzuki Nao，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shirou

臨床と研究 78 ( 11 ) 67-71 2001.11

Research paper (scientific journal), Joint Work

Paclitaxel and SN-38 overcome cisplatin resistance of ovarian cancer cell lines by down -regulating the influx and efflux system of cisplatin

Komuro Y, Udagawa Y, Susumu Nobuyuki, Aoki Daisuke, Kubota Tetsuro，Nozawa Siro

Japanese Journal of Cancer research 92 ( 11 ) 1242-1250 2001.11

Research paper (scientific journal), Joint Work

Paclitaxel and SN-38 overcome cisplatin resistance of ovarian cancer cell lines by down-regulating the influx and efflux system of cisplatin

Komuro Yuuki, Udagawa Yasuhiro, Susumu Nobuyuki, Aoki Daisuke, Kubota Tetsuro, Nozawa Shiro

Japanese Journal of Cancer Research 92 ( 11 ) 1242-1250 2001.11

Research paper (scientific journal), Joint Work

遺伝性非腺腫性大腸癌(HNPCC)と婦人科癌

Banno Kouji，Nikata Masanobu，Hirasawa Akira，Susumu Nobuyuki，Aoki Daisuke，Udagawa Yasuhiro，Nozawa Shirou

産婦人科の実際 50 ( 12 ) 1819-1826 2001.11

Research paper (scientific journal), Joint Work

わが教室における婦人科癌の化学療法

Komiyama Shinichi，Fukuchi Takeshi，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shirou

産婦人科治療 83 ( 3 ) 350-354 2001.09

Research paper (scientific journal), Joint Work

上皮性卵巣癌におけるpTNM分類と腫瘍マーカー

Aoki Daisuke，Susumu Nobuyuki，Saitou Eiko，Komiyama Shinichi，Nozawa Shirou

日本分子腫瘍マーカー研究会誌 16 18-19 2001.09

Research paper (scientific journal), Joint Work

卵巣明細胞腺癌におけるPAI-1発現の生物学的意義

Komiyama Shinichi，Aoki Daisuke，Kanasugi Masaru，Hirasawa Akira，Susumu Nobuyuki，Nozawa Shirou

日本分子腫瘍マーカー研究会誌 16 48-49 2001.09

Research paper (scientific journal), Joint Work

タキサン製剤を中心とした卵巣癌治療の実際―Paclitaxel-Carboplatin療法の有用性―

Kimura Eizou，Yasuda Makoto，Ochiai Kazuhiko，Ochiai Kazunori，Aoki Daisuke，Kikuchi Yoshihiro，Nishida Masahito，Furukawa Takamasa，Akamatsu Tatsuya，Saitou Kaoru，Joubou Toshiko

Oncology & Chemotherapy 17 ( 3 ) 202-208 2001.08

Research paper (scientific journal), Joint Work

タキサン製剤と子宮体癌

Aoki Daisuke，Saitou Eiko，Nozawa Shirou

Oncology & Chemotherapy 17 ( 3 ) 221-225 2001.08

Research paper (scientific journal), Joint Work

子宮内膜癌に対するホルモン療法

Susumu Nobuyuki，Aoki Daisuke，Suzuki Nao，Nozawa Shirou

癌と化学療法 28 ( 7 ) 934-945 2001.07

Research paper (scientific journal), Joint Work

子宮内膜症の局所環境におけるtransforming growth factor-betal(TGFβ1)の産生および活性化機構―その腫瘍様性格一端として―

Komiyama Shinichi，Aoki Daisuke，Susumu Nobuyuki，Nozawa Shirou

エンドメトリオーシス研究会誌 22 61-61 2001.07

Research paper (scientific journal), Joint Work

がん治療におけるEvidenceの捉え方

Aoki Daisuke

化療ニュース 10 ( 1 ) 1-3 2001.06

Research paper (scientific journal), Single Work

Detection of chromosomal alteration in ovarian cancers using doubletargeted FISH

Susumu Nobuyuki, Noda Tomomi, Suzuki Nan, Kanasugi Masaru, Aoki Daisuke, Nozawa Shiro, Tsuda Hitoshi, Hirohashi Setsuo

Acta Histochemica et Cytochemica 34 ( 1 ) 77-77 2001.04

Research paper (scientific journal), Joint Work

The expression of β1,4-glactosyltransferase in human trophoblasts

Saitoh Eiko, Aoki Daisuke, Susumu Nobuyuki, Suzuki Nao, Kataoka Fumio, Nozawa Shiro

Acta Histochemica et Cytochemica 34 ( 1 ) 62-62 2001.04

Research paper (scientific journal), Joint Work

酢酸ゴセレリン

Aoki Daisuke

臨床と薬物治療 20 ( 4 ) 352-353 2001.04

Research paper (scientific journal), Single Work

卵巣癌に対するPaclitaxelとCarboplatinの併用化学療法のPilot-Phase I Study(JKTB)―推奨用量について―

Yasuda Makoto，Kimura Eizou，Ochiai Kazunori，Tada Seirou，Udagawa Yasuhiro，Aoki Daisuke，Nozawa Shirou，Kikuchi Yoshihiro，Kita Tsunekazu，Nishida Masato，Tsunoda Hajime

癌と化学療法 28 ( 4 ) 493-498 2001.04

Research paper (scientific journal), Joint Work

子宮頚がん検診

Aoki Daisuke，Suzuki Nao，Tamada Yutaka，Kataoka Fumio

がん検診の適正化に関する調査研究事業　新たながん検診手法の有効性の評価報告書 121-175 2001.03

Research paper (scientific journal), Joint Work

卵巣がん検診

Aoki Daisuke，Komiyama Shinichi，Saitou Eiko，Setou Eri

がん検診の適正化に関する調査研究事業　新たながん検診手法の有効性の評価報告書 211-246 2001.03

Research paper (scientific journal), Joint Work

子宮体がん検診

Aoki Daisuke，Saitou Eiko，Susumu Nobuyuki，Kanasugi Masaru

がん検診の適正化に関する調査研究事業　新たながん検診手法の有効性の評価報告書 177-210 2001.03

Research paper (scientific journal), Joint Work

子宮内膜症を伴う卵巣癌の生物学的特性　―卵巣癌明細胞腺癌を中心に―

Aoki Daisuke，Komiyama Shinichi，Susumu Nobuyuki，Nozawa Shirou

日本臨床　子宮内膜症 59 ( suppl 1 ) 213-216 2001.01

Research paper (scientific journal), Joint Work

2色FISH法の子宮頸部細胞診への応用

Susumu Nobuyuki，Noda Tomomi，Terui Hitomi，Suzuki Nao，Aoki Daisuke，Nozawa Shirou，Tsuda Hitoshi

日本臨床細胞学会東京都支部会報 18 ( 1 ) 14-20 2000.12

Research paper (scientific journal), Joint Work

Imbalanced expression of TAN-1and human Notch4 in endometrial cancers

Suzuki Takashi, Aoki Daisuke, Susumu Nobuyuki, Udagawa Yasuhiro, Nozawa Shiro

International Journal of Oncology 17 ( 6 ) 1131-1139 2000.12

Research paper (scientific journal), Joint Work

ドキタキセルと卵巣癌

Komiyama Shinichi，Aoki Daisuke

婦人科がん化学療法共同研究会　化療ニュース 9 ( 3 ) 5-5 2000.12

Research paper (scientific journal), Joint Work

Microsatellite markerを用いた子宮体癌の家族集積性についての検討

Kanasugi Masaru，Udagawa Yasuhiro，Nikata Masanobu，Nakada Sakura，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shirou

日本分子腫瘍マーカー研究会誌 15 31-31 2000.10

Research paper (scientific journal), Joint Work

子宮頸癌検診

Aoki Daisuke，Saitou Eiko，Nozawa Shirou

臨床検査 44 ( 11 ) 1206-1211 2000.10

Research paper (scientific journal), Joint Work

Telomerase activity in gynecological tumors

Sakamoto Masaru, Toyoizumi Takeshi, Kikuchi Yoshihiro, Okamoto Aikou, Nakayama Hiroki, Aoki Daisuke, Yamamoto Kaichiro, Hata Hiroki, Sugishita Tadashi, Tenjin Yoshio

Oncology Reports 7 ( 5 ) 1003-1009 2000.09

Research paper (scientific journal), Joint Work

卵巣癌

Nozawa Shirou，Aoki Daisuke

Medicament News ( 1668 ) 8-10 2000.09

Research paper (scientific journal), Joint Work

異所性子宮内膜が有する細胞増殖抑制効果の研究　―卵巣明細胞腺癌との相互作用を通じて―

Aoki Daisuke

日本産科婦人科学会雑誌 52 ( 8 ) 1150-1161 2000.08

Research paper (scientific journal), Single Work

Cisplatin sensitivity of ovarian cancer in the histoculture drug response assay correlates to clinical response to combination chemotherapy with cisplatin,doxorubicin and cyclophosphamide

Ohie Shinji, Udagawa Yasuhiro, Kozu Akiko, Komuro Yuki, Aoki Daisuke, Nozawa Shiro, Moossa AR, Hoffman Robart M

Anticancer Research 20 ( 3B ) 2049-2054 2000.05

Research paper (scientific journal), Joint Work

卵巣癌に対する新たな抗癌剤感受性試験（HDRA）の有用性

Nakada Sakura，Aoki Daisuke，Udagawa Yasuhiro，Nozawa Shirou

組織培養工学 26 ( 4 ) 19-22 2000.04

Research paper (scientific journal), Joint Work

急速な転帰を遂げた肉腫様変化を伴う子宮頸部腺扁平上皮癌の一部

Tajima Toshihide, Susumu Nobuyuki, Nakada Sakura, Hayashi Shigenori, Tominaga Eiichirou, Banno Kouji, Nozawa Shirou, Mukai Makio

日本産科婦人科学会東京地方部会会誌 49 ( 1 ) 35-39 2000.03

Research paper (scientific journal), Joint Work

子宮体癌の補助化学療法の評価─予後からみた放射線療法との比較において─　当院における子宮体癌術後療法の治療成績

Udagawa Yasuhiro，Kanasugi Masaru，Setoh Eri，Nakada Sakura，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shiro

第38回子宮癌研究会記録 59-64 2000.02

Research paper (scientific journal), Joint Work

primary serous carcinoma of the peritoneum（PSCP）に関する臨床病理学的検討

Komiyama Shinichi，Aoki Daisuke，Udagawa Yasuhiro，Nozawa Shiro

Oncology & Chemotherapy 16 ( 1 ) 21-26 2000.02

Research paper (scientific journal), Joint Work

子宮体部漿液性腺癌とその治療

Nakada Sakura，Udagawa Yasuhiro，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shiro

Oncology & Chemotherapy 16 ( 1 ) 41-44 2000.02

Research paper (scientific journal), Joint Work

Application of double-targeted fluorescence in sitehybridization for cytological examinations in gynecological field

Susumu Nobuyuki, Tsuda Hitoshi, Aoki Daisuke, Komiyama Shinichi, Udagawa Yasuhiro, Nozawa Shiro, Hirohashi Setsuo

Acta Histochemica et Cytochemica 32 ( 6 ) 508-508 1999.12

Research paper (scientific journal), Joint Work

わが教室における腫瘍マーカー検査

Hirasawa Akira，Aoki Daisuke，Udagawa Yasuhiro，Nozawa Shiro

産婦人科治療 79 ( 6 ) 680-685 1999.12

Research paper (scientific journal), Joint Work

Carbohydrate epitopes and mucins expressed by 17 human ovarian carcinoma cell lines

Tamada Yutaka, Iida Shin-ichiro, Aoki Daisuke, Nozawa Shiro, Irimura Tatsuro

Oncology Research 11 ( 5 ) 233-241 1999.11

Research paper (scientific journal), Joint Work

Behavior of GAT in sera of patients with ovarian cancer

Aoki Daisuke, Saitoh Eiko, Susumu Nobuyuki, Udagawa Yasuhiro, Nozawa Shiro

Tumor Biology 20 ( Suppl 2 ) 13-13 1999.10

Research paper (scientific journal), Joint Work

The Histoculture Drug Response Assay (HDRA)as a novel drug sensitivity test for ovarian cancer chemotherapy

Udagawa Yasuhiro, Kohzu Akiko, Ohie Shinji, Horiuchi Miwa, Nakada Sakura, Susumu Nobuyuki, Aoki Daisuke, Nozawa Shiro

International Journal of Gynecological Cancer 9 ( Suppl 1 ) 13-13 1999.09

Research paper (scientific journal), Joint Work

The relationship between MSN-1-reactive carbohydrate antigens and α-1,2 fucosyltransferase genes expressed in endometrial adenocarcinoma

Tominaga Eiichiro, Aoki Daisuke, Hirasawa Akira, Setoh Eri, Susumu Nobuyuki, Udagawa Yasuhiro, Nozawa Shiro

International Journal of Gynecological Cancer 9 ( Suppl 1 ) 68-69 1999.09

Research paper (scientific journal), Joint Work

婦人科細胞診の実施と評価　─婦人科細胞診の有用性について─

Aoki Daisuke

日本産科婦人科学会雑誌 51 ( 9 ) N-299-N-302 1999.09

Research paper (scientific journal), Single Work

悪性転化を伴う成熟嚢胞性奇形腫の術前検査所見に関する検討

Takehara Kyoko，Aoki Daisuke，Tominaga Eiichiro，Nakagawa Hiroyuki，Yamashita Hiroshi，Hirao Nobumaru，Kubushiro Kaneyuki，Udagawa Yasuhiro，Yoshimura Yasunori，Nozawa Shiro

日本産科婦人科学会東京地方部会会誌 48 ( 3 ) 420-425 1999.09

Research paper (scientific journal), Joint Work

Genetic analysis of chromosome 17 and 1 in cervical cancers using fluorescencein situ hybridization and RFLP-Southern Blot

Susumu Nobuyuki, Tsuda Hitoshi, Aoki Daisuke, Udagawa Yasuhiro, Hirasawa Akira, Kanasugi Masaru, Nozawa Shiro

International Journal of Gynecological Cancer 9 ( Suppl 1 ) 101-102 1999.09

Research paper (scientific journal), Joint Work

当院における子宮体癌術後療法の治療成績

Udagawa Yasuhiro，Kanasugi Masaru，Setoh Eri，Nakada Sakura，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shiro

産科と婦人科 66 ( 9 ) 1195-1200 1999.09

Research paper (scientific journal), Joint Work

婦人科癌における新しい抗癌剤感受性試験の有用性

Udagwa Yasuhiro，Horiuchi Miwa，Nakada Sakura，Aoki Daisuke，Nozawa Shiro

産婦人科の実際 48 ( 7 ) 987-992 1999.07

Research paper (scientific journal), Joint Work

卵巣癌担癌状態における癌関連ガラクトース転移酵素GATの血中上昇機構についての検討

Saitoh Eiko，Aoki Daisuke，Susumu Nobuyuki，Tominaga Eiichiro，Suzuki Takashi，Udagawa Yasuhiro，Nozawa Shiro

腫瘍マーカー研究会誌 14 27-29 1999.06

Research paper (scientific journal), Joint Work

卵巣がん

Aoki Daisuke

毎日ライフ 30 ( 6 ) 28-32 1999.06

Research paper (scientific journal), Single Work

境界悪性卵巣腫瘍の取り扱い　─表層上皮性境界悪性腫瘍に関する問題点をふまえて─

Aoki Daisuke，Komiyama Shinichi，Nozawa Shiro

臨床婦人科産科 53 ( 6 ) 834-837 1999.06

Research paper (scientific journal), Joint Work

内膜癌の術後追加治療，その適応と選択　リスク因子による術後治療法の選択

Udagawa Yasuhiro，Nakada Sakura，Kanasugi Masaru，Setoh Eri，Susumu Nobuyuki，Aoki Daisuke，Nozawa Shiro

産科と婦人科 66 ( Suppl ) 114-118 1999.04

Research paper (scientific journal), Joint Work

Expression of trophinin,tastin,and bystin by trophoblast and endometrial cells in human placenta

Suzuki Nao, Nakayama Jun, Shih Le-ming, Aoki Daisuke, Nozawa Shiro, Fukuda Michiko N

Biology of Reproduction 60 ( 3 ) 621-627 1999.03

Research paper (scientific journal), Joint Work

Prognosis of Japanese patients with ovarian clear cell carcinoma associated with pelvic endometriosis: Clinicopathologic evaluation

Komiyama Shin-ichi, Aoki Daisuke, Tominaga Eiichiro, Susumu Nobuyuki, Udagawa Yasuhiro, Nozawa Shiro

Gynecologic Oncology 72 ( 3 ) 342-346 1999.03

Research paper (scientific journal), Joint Work

癌関連ガラクトース転移酵素(GAT)

Udagawa Yasuhiro, Ueshima Takao, Susumu Nobuyuki, Aoki Daisuke, Nozawa Shirou

臨床科学 35 ( 3 ) 377-382 1999.03

Research paper (scientific journal), Joint Work

Differences in apoptosis induced by anticancer drugs in sublines(SKG-3a,SKG-3b)from a human uterine cervical epidermoid carcinoma

Takahashi Motoo, Kataoka Shiro, Kobayashi Eiichi, Udagawa Yasuhiro, Aoki Daisuke, Oie Shinji, Kozu Akiko, Nozawa Shiro

Oncology Research 11 ( 2 ) 71-75 1999

Research paper (scientific journal), Joint Work

Two soluble forms of β1,4-galactosyltransferase released from ovarian cancer cells and from COS-1 cells transfected with its cDNA

Aoki Daisuke, Saitoh Eiko, Matsumoto Yumi, Tominaga Eiichiro, Hirasawa Akira, Susumu Nobuyuki, Udagawa Yasuhiro, Nozawa Shiro

Acta Histochemica et Cytochemica 32 ( 3 ) 209-214 1999

Research paper (scientific journal), Joint Work

抗癌剤感受性検査

Udagawa Yasuhiro, Ooie Shinji, Kouzu Akiko, Tsuda Mayumi, Horiuchi Miwa, Nakada Sakura, Aoki Daisuke, Nozawa Shirou

産婦人科の世界　’98冬季増刊号卵巣―機能と病態生理― 50 ( 冬季増刊号 ) 304-309 1998.12

Research paper (scientific journal), Joint Work

Neuroendocrine featureを伴った子宮体癌の1例

Tominaga Eiichirou, Aoki Daisuke, Okamoto Masatsugu, Kubushiro Kaneyuki, Yoshimura Yasunori, Nozawa Shirou, Mukai Makio

日本産科婦人科学会東京地方部会会誌 47 ( 4 ) 446-449 1998.12

Research paper (scientific journal), Joint Work

A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer

Kiguchi Kazushige, Kubota Tetsuro, Aoki Daisuke, Udagawa Yasuhiro, Yamanouchi Shizuka, Saga Masahiko, Amemiya Akira, Sun F.x, Nozawa Shiro, Moossa A.r, Hoffman R.m

Clinical and Experimental Metastasis 16 ( 8 ) 751-756 1998.11

Research paper (scientific journal), Joint Work

β1，4-ガラクトース転移酵素のゴルジ局在機構

Aoki Daisuke, Susumu Nobuyuki, Saitou Eiko, Matsumoto Yumi, Nozawa Shirou

Mebio 15 ( 10 ) 101-103 1998.10

Research paper (scientific journal), Joint Work

酢酸メドロキシプロゲステロン投与によって長期生存が得られた子宮体癌肺転移の2例

Setou Eri, Aoki Daisuke, Nakada Sakura, Nikata Masanobu, Udagawa Yasuhiro, Oota Hiroaki, Yoshimura Yasunori, Nozawa Shirou

日本産科婦人科学会東京地方部会会誌 47 ( 2 ) 207-210 1998.06

Research paper (scientific journal), Joint Work

新たな腫瘍マーカーGAT

Aoki Daisuke, Udagawa Yasuhiro, Saitou Eiko, Nozawa Shirou

産婦人科の実際 47 ( 6 ) 885-893 1998.06

Research paper (scientific journal), Joint Work

組織片培養法を用いた新たな抗癌剤感受性試験の有用性の検討―女性性器癌に対する有効薬剤の選択を目指して―

Udagawa Yasuhiro, Horiuchi Miwa, Kouzu Akiko, Ooie Shinji, Nakada Sakura, Komuro Yuuki, Aoki Daisuke, Nozawa Shirou

Oncology & Chemotherapy 14 ( 2 ) 94-98 1998.05

Research paper (scientific journal), Joint Work

広汎性子宮全摘における基靱帯処理の工夫

Kubushiro Kaneyuki, Susumu Nobuyuki, Takamatsu Kiyoshi, Aoki Daisuke, Tsukazaki Katsumi, Udagawa Yasuhiro, Oota Hiroaki, Nozawa Shirou

産婦人科手術 9 35-37 1998.05

Research paper (scientific journal), Joint Work

卵巣癌と内膜症性嚢胞との鑑別におけるGAT(癌関連ガラクトース転移酵素)の有用性の検討

Uejima Takao, Udagawa Yasuhiro, Saitou Eiko, Komiyama Shinichi, Aoki Daisuke, Nozawa Shirou

腫瘍マーカー研会誌 12 155-157 1998.03

Research paper (scientific journal), Joint Work

Clinical characteristics of a new developed ovarian tumour marker, galactosyltransferase associated with tumour (GAT)

Udagawa Yasuhiro, Aoki Daisuke, Ito Kohtaro, Uejima Takao, Uemura Morito, Nozawa Shiro

Eur J Cancer 34 ( 4 ) 489-495 1998.03

Research paper (scientific journal), Joint Work

HDRA(Histoculture drug response assay)によるcisplatinに対する卵巣癌の感受性判定と腫瘍マーカーの推移についての検討

Aoki Daisuke, Udagawa Yasuhiro, Saitou Eiko, Komuro Yuuki, Nikata Masanobu, Kouzu Akiko, Ooie Shinji, Nozawa Shirou

腫瘍マーカー研会誌 12 237-239 1998.03

Research paper (scientific journal), Joint Work

腫瘍マーカーとしての糖転移酵素─癌関連ガラクトース転移酵素の臨床的意義─

Udagawa Yasuhiro, Ueshima Takao, Aoki Daisuke, Nozawa Shirou

臨婦産 52 ( 2 ) 154-157 1998.02

Research paper (scientific journal), Joint Work

腫瘍マーカーの歴史と展開

Aoki Daisuke, Nozawa Shirou

臨婦産 52 ( 2 ) 121-125 1998.02

Research paper (scientific journal), Joint Work

婦人科腫瘍におけるテロメラーゼ活性測定の臨床的意義に関する多施設共同研究

Sakamoto Masaru, Toyoizumi Takeshi, Kikuchi Yoshihiro, Okamoto Aikou, Tanaka Tadao, Nakayama Hiroki, Katou Hisamori, Okajima Hiroyuki, Aoki Daisuke, Tominaga Eiichirounozawa Shirou, Yamamoto Kaichirou, Obata Koushirou, Hoshiai Hiroshi, Hamano Mieko, Hata Hiroki, Kuramoto Hiroyuki, Sugishita Tadashi, Tenjin Yoshio, Yasumoto Shigeru

Oncol Chemother 14 ( 1 ) 41-52 1998.02

Research paper (scientific journal), Joint Work

Effects of dienogest, a synthetic steroid, on experimental endometriosis in rats

Katsuki Yukio, Takano Yukiko, Futamura Yoshihiro, Shibutani Yasunori, Aoki Daisuke, Udagawa Yasuhiro, Nozawa Shiro

Eur J Endocrinol 138 216-226 1998

Research paper (scientific journal), Joint Work

卵巣癌と内膜症性嚢胞との鑑別におけるGAT（癌関連ガラクトース転移酵素）の有用性の検討

Uejima Takao, Udagawa Yasuhiro, Saitou Eiko, Komiyama Shinichi, Aoki Daisuke, Nozawa Shirou

腫瘍マーカー研究会誌 12 155-157 1998

Research paper (scientific journal), Joint Work

わが教室における子宮体癌の取り扱い方

Udagawa Yasuhiro, Nakada Sakura, Nikata Masanobu, Aoki Daisuke, Nozawa Shirou

産婦治療 75 ( 6 ) 679-684 1997.12

Research paper (scientific journal), Joint Work

子宮体部漿液性腺癌の2例

Nakada Sakura, Udagawa Yasuhiro, Irie Takuya, Nikata Masanobu, Komiyama Shinichi, Kubushiro Kaneyuki, Aoki Daisuke, Yoshimura Yasunori, Nozawa Shirou

日産婦東京会誌 46 ( 4 ) 450-453 1997.12

Research paper (scientific journal), Joint Work

婦人科がんと新しい腫瘍マーカー

Kubushiro Kaneyuki, Takamatsu Kiyoshi, Aoki Daisuke, Tsukazaki Katsumi, Udagawa Yasuhiro, Nozawa Shirou

産と婦 64 ( 6 ) 776-784 1997.06

Research paper (scientific journal), Joint Work

婦人科腫瘍　細胞診--細胞採取法を中心に--

Udagawa Yasuhiro, Aoki Daisuke, Nozawa Shirou

産と婦 64（Suppl） 184-185 1997.04

Research paper (scientific journal), Joint Work

卵巣癌：卵巣癌と糖鎖関連抗原

Aoki Daisuke, Udagawa Yasuhiro, Saitou Eiko, Nozawa Shirou

医と薬学 37 ( 4 ) 809-816 1997.04

Research paper (scientific journal), Joint Work

腫瘍マーカーを用いた卵巣がん検診の試み--新たな腫瘍マーカーGATの有用性についての検討--

Saitou Eiko, Udagawa Yasuhiro, Komiyama Shinichi, Aoki Daisuke, Nozawa Shirou

産業衛誌 39（Suppl） S78-S78 1997.04

Research paper (scientific journal), Joint Work

わが教室における卵巣癌の診断と治療

Aoki Daisuke, Udagawa Yasuhiro, Komiyama Shinichi, Nozawa Shiro

産婦治療 74 ( 2 ) 213-218 1997.02

Research paper (scientific journal), Joint Work

Dienogest,a novel synthetic steroid,overcomes hormone-dependent cancer in a different manner than progestins

Katsuki Yukio, Shibutani Yasunori, Aoki Daisuke, Nozawa Shiro

Cancer 79 ( 1 ) 169-176 1997.01

Research paper (scientific journal), Joint Work

卵巣癌におけるDose intensive chemotherapy--supporting therapyも含めて--

Udagawa Yasuhiro, Aoki Daisuke, Nozawa Shiro

産婦の実際 46 ( 1 ) 11-20 1997.01

Research paper (scientific journal), Joint Work

Animal studies on the endocrinological profile of dienogest,a novel synthetic steroid

Katsuki Yukio, Sasagawa Shinichi, Takano Yukiko, Shibutani Yasunori, Aoki Daisuke, Udagawa Yasuhiro, Nozawa Shiro

Drugs exptl. clin. res. 23 ( 2 ) 45-62 1997

Research paper (scientific journal), Joint Work

癌と糖転移酵素--癌関連ガラクトース転移酵素を中心に--

Aoki Daisuke

慶應医 74 ( 2 ) 151-152 1997

Research paper (scientific journal), Single Work

腫瘍マーカー，CA602・CA546を用いた卵巣がん検診の可能性について--prospective studyの成績から--

Udagawa Yasuhiro, Saitoh Miwa, Takamatsu Kiyoshi, Ueshima Takao, Aoki Daisuke, Nozawa Shiro

腫瘍マーカー研会誌 11 35-37 1996.10

Research paper (scientific journal), Joint Work

血中セロトニン値が高値を示した子宮頚部原発神経内分泌癌の1例

Akiba Yasuo, Mikami Mikio, Komuro Yuki, Kishikawa Tsuyoshi, Sakuma Yuichi, Aoki Daisuke, Udagawa Yasuhiro, Mukai Makio, Yoshimura Yasunori, Nozawa Shiro

日産婦会誌 48 ( 10 ) 897-900 1996.10

Research paper (scientific journal), Joint Work

western blottingを中心とした卵巣癌細胞のGT/GAT生産能の検索

Saitoh Eiko, Aoki Daisuke, Ueshima Takao, Udagawa Yasuhiro, Nozawa Shiro

腫瘍マーカー研会誌 11 175-177 1996.10

Research paper (scientific journal), Joint Work

CA602・CA546および超音波断層法の組み合わせによる卵巣腫瘍の良・悪性の鑑別における診断能

Saitoh Miwa, Udagawa Yasuhiro, Natori Michiya, Aoki Daisuke, Nozawa Shiro

腫瘍マーカー研会誌 11 39-41 1996.10

Research paper (scientific journal), Joint Work

婦人科疾患における尿中hCGβ-core fragmentの腫瘍マーカーとしての有用性の検討

Okamoto Tomomitsu, Tomoda Yutaka, Gotoh Setsuko, Matsui Hideo, Sekiya Souei, Yasugi Toshiharu, Yoshikawa hiroyuki, Taketani Yuji, Katoh Shinya, Aoki Daisuke, Nozawa Shiro, Yudate Tamaki, Iizuka Seiko, Takayama Masaomi, Murae Masahi, Kimura Eizo, Tanaka Tadao, Kuzaya Kazuo, Kurachi Hirohisa, Shiota Mitsuru, Noda Kiichiro

産婦治療 73 ( 3 ) 339-345 1996.09

Research paper (scientific journal), Joint Work

中隔子宮の片側に発生した子宮体癌の1例

Nikata Masanobu, Honda Takahiro, Mikami Mikio, Kubushiro Kaneyuki, Aoki Daisuke, Udagawa Yasuhiro, Ota Hiroaki, Yoshimura Yasunori, Nozawa Shiro

日産婦東京会誌 45 ( 3 ) 363-366 1996.09

Research paper (scientific journal), Joint Work

β1,4-Galactosyltransferase expressed in ovarian cancer cells

Aoki Daisuke, Saitoh Eiko, Susumu Nobuyuki, Kawakami Hayato, Uejima Takao, Udagawa Yasuhiro, Hirano Hiroshi, Nozawa Shiro

Acta Histochem Cytochem 29 232-233 1996.08

Research paper (scientific journal), Joint Work

腫瘍マーカーを用いた卵巣がん検診の試み--カットオフ値についての検討--

Saitoh Eiko, Udagawa Yasuhiro, Saitoh Miwa, Aoki Daisuke, Nozawa Shiro

第69回日本産業衛生学会講演集 38臨時増刊号 S351 1996.06

Research paper (scientific journal), Joint Work

血中セロトニン値が高値を示した子宮頸部原発神経内分泌癌の1例

Akiba Yasuo, Mikami Mikio, Komuro Yuuki, Kishikawa Takeshi, Sakuma Yuuichi, Aoki Daisuke, Udagawa Yasuhiro, Mukai Makio, Yoshimura Yasunori, Nozawa Shiroh

日産婦会誌 48 897-900 1996

Research paper (scientific journal), Joint Work

腫瘍マーカー・・最近の進歩　体液・分泌液の腫瘍マーカー　婦人科の腫瘍マーカー

Takamatsu Kiyoshi, Kubushiro Kaneyuki, Aoki Daisuke, Tsukazaki Katsumi, Udagawa Yasuhiro, Nozawa Shiro

臨床検査 39 ( 12 ) 1273-1280 1995.12

Research paper (scientific journal), Joint Work

・・子宮体癌の補助化学療法・・子宮体癌の術後療法の選択について

Udagawa Yasuhiro, Komuro Yuuki, Miyashita Akiko, Aoki Daisuke, Nozawa Shiro

産と婦 62 ( 9 ) 1293-1296 1995.09

Research paper (scientific journal), Joint Work

Immunocytochemical localization of the protein reactive to human β1,4-galactosyltransferase antibodies during chick embryonic skin differentiation

Akimoto Y, Obinata A, Endo H, Furukawa K, Aoki D, Nozawa S, Hirano H

Anatl Rec 234 109-119 1995.09

Research paper (scientific journal), Joint Work

Genotypes of fucosyl transferase III and its involvement in fucosylated carbohydrate antigen expressed in endometrial adenocarcinoma

Aoki D, Kato D, Kimura Y, Saitoh E, Udagawa Y, Nozawa S

Intl J Gynec Cancer 5 ( 1 ) 30 1995.09

Research paper (scientific journal), Joint Work

Phenotypic alteration of carbohydrate antigens in gynecological malignancy

Aoki D, Susumu N, Kawakami H, Hirano H, Nozawa S

Acta Histochem Cytochem 28 ( 2 ) 197-201 1995.09

Research paper (scientific journal), Joint Work

Practical use of the estimation of three new tumor markers in the mass screening for epithelial ovarian cancer

Takamatsu K, Udagawa Y, Saitoh M, Itoh K, Uejima T, Aoki D, Nozawa S

Intl J Gynec Cancer 5 ( 1 ) 50 1995.09

Research paper (scientific journal), Joint Work

腫瘍マーカ－，CA602・CA546を用いた卵巣がん検診の可能性と問題点・・retrospectiveおよびprospective studyから・・

Aoki Daisuke, Udagawa Yasunori, Saito Miwa, Ito Koutaro, Ueshima Takao, Takamatsu Kiyoshi, Nozawa Shiro

JSCT Educational Book 1995 10 182-185 1995.09

Research paper (scientific journal), Joint Work

子宮体癌の手術術式および術後療法の選択

Udagawa Yasuhiro, Komuro Yuuki, Aoki Daisuke, Nozawa Shiro

JSCT Educational Book 1995 10 405-408 1995.09

Research paper (scientific journal), Joint Work

新たな腫瘍マーカーGATの卵巣腫瘍良・悪性の鑑別，および治療経過のモニタリングにおける有用性の検討

Udagawa Yasuhiro, Saito Miwa, Ito Koutaro, Ueshima Takao, Aoki Daisuke, Nozawa Shiro

腫瘍マーカー研会誌 10 37-40 1995.08

Research paper (scientific journal), Joint Work

＜特集＞婦人科癌治療の最近の動向子宮体癌の手術療法の選択

Aoki Daisuke, Udagawa Yasunori, Nozawa Shiro

癌と化療 22 ( 9 ) 1163-1168 1995.08

Research paper (scientific journal), Joint Work

Trophinin and tastin ; a novel cel adhesion molecule complex with potential involvement in embryo implantation

Fukuda M, Sato T, Nakayama J, Klier G, Mikami M, Aoki D, Nozawa S

Genes Dev 9 1199-1210 1995.05

Research paper (scientific journal), Joint Work

新たな腫瘍マーカーを用いた卵巣がんのスクリーニングの試み

Saito Eiko, Udagawa Yasuhiro, Saito Miwa, Aoki Daisuke, Nozawa Shiro

産業衛生学会誌 37 S269 1995.04

Research paper (scientific journal), Joint Work

子宮癌と腫瘍マーカー

Takamatsu Kiyoshi, Kubushiro Kaneyuki, Aoki Daisuke, Tsukazaki Katsumi, Udagawa Yasuhiro, Nozawa Shiro

産婦治療 70 ( 4 ) 405-411 1995.04

Research paper (scientific journal), Joint Work

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