論文 - 坂元　亨宇

Prediction of Invasive Activities in Hepatocellular Carcinomas with Special Reference to α-Fetoprotein and Des-γ-carboxyprothrombin

'Gotoh M, Nakatani T, Masuda T, Mizuguchi Y, Sakamoto Michiie, Tsuchiya R, Kato H, Furuta K'

Japanese Journal of Clinical Oncology 33 （ 10 ） 522-526 2003年

研究論文（学術雑誌）, 単著

Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells;

'Kanetaka K, Sakamoto Michiie, Yamamoto Y, Takamura M, Kanematsu T, Hirohashi Setsuo'

Journal of Gastroenterology and Hepathology 18   1309-1314 2003年

研究論文（学術雑誌）, 単著

'Expression of Different Glycoforms of Membrane Mucin (MUC1)and Secretory Mucin(MUC2,MUC5AC and MUC6)in Pancreatic Neoplasms'

'Horinouchi M, Nagata K, Nakamura A, Goto M, Takao S, Sakamoto Michiie, Fukushima N, Miwa A, Irimura T, Imai K, Sato, Yonezaki S'

Acta Histochemica et Cytochemica 36 （ 5 ） 443-453 2003年

研究論文（学術雑誌）, 単著

Evaluation of a Whole-Genome Amplification Method Based on Adaptor-Ligation PCR of Randomly Sheared Genomic DNA

'Tanabe C, Aoyagi K, Sakiyama T, Kohno T, Yanagitani N, Akimoto S, Sakamoto Michiie, Sakamoto H, Jun Yokota, Ohki M, Terada M, Yoshida T'

Genes chromosomed&cancer 38   168-176 2003年

研究論文（学術雑誌）, 単著

Nemo –like kinase induces apoptosis in DLD-1 human colon cancer cells

'Yasuda J, Tsuchiya A, Yamada Taketo, Sakamoto Michiie, Sekiya T, Hirohashi Setsuo'

Biochemical and Biophysical Research Communications 308   227-233 2003年

研究論文（学術雑誌）, 単著

Increaseda protein expression of DNA methyltranseferase(DNMT)1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas;

'Saito Y, Kanai Yae, Nakagawa T, Sakamoto Michiie, Saito H, Ishii H, Hirohashi Setsuo'

International Journal of Cancer 105   527-532 2003年

研究論文（学術雑誌）, 単著

Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas;

'Takamura M, Sakamoto Michiie, Ino Y, Shimamura T, Ichida T, Asakura H, Hirohashi Setsuo'

Cancer science 194 （ 5 ） 425-430 2003年

研究論文（学術雑誌）, 単著

β-Catenin mutations in pulmonary blastomas:association with morule formation;

'Sekine S, Shibata Rie, Matsuo Y, Maeshima A, Ishii G, Sakamoto Michiie, Hirohashi Setsuo'

Journal of Pathology    214-221 2003年

研究論文（学術雑誌）, 単著

'Aberrantο-glycosylation inhibits stable expression of dysadherin,a carcinoma-associated antigen,and facilitates cell-cell adhesion;'

'Tsuji H, Takasaki S, Sakamoto Michiie, Irimura T, Hirohashi Setsuo'

Glycobiology 13 （ 7 ） 521-527 2003年

研究論文（学術雑誌）, 単著

Clear Cell Endocrine Tumor of the Pancreas Which is Not Associaated with von Hippel-Lindau Disease:

'Nunobe S, Fukushima N, Yachida S, Shimada K, Kosuge T, Sakamoto Michiie'

Report of Case:Surg Today 33   470-474 2003年

研究論文（学術雑誌）, 単著

Overexpression of orphan G-Protein-Coupled Receptor,Gpr49,in human hepatocellular carcinoma with β-catenin mutations

Yamamoto Y, Sakamoto Michiie, Fujii Gen, Tsuiji Hitomi, Kanetaka Kenzo, Asaka Masahiro, Hirohashi Setsuo

Hepatology 37 （ 3 ） 528-533 2003年

研究論文（学術雑誌）, 共著

Craniopharyngiomas of Adamantinomatous Type Harbor β-Catenin Gene Mutations

Sekine Shigeki, Shibata Tatsuhiro, Kokubo Akiko, Morishita Yukio, Noguchi Masayuki, Nakanishi Yukihiro, Noguchi Masayuki, Nakanishi Yukihiro, Sakamoto Michiie, Hirohashi Setsuo

American journal of pathology 161 （ 6 ） 1997-2001 2002年12月

研究論文（学術雑誌）, 共著

Satellite lesions in patients with small hepatocellular carcinoma with reference to clinicopathologic features

Okusaka, T., Okada, S., Ueno, H., Ikeda, M., Shimada, K., Yamamoto, J., Kosuge, T., Yamasaki, S., Fukushima, N. and Sakamoto, M.

Cancer 95 （ 9 ） 1931 - 7 2002年11月

ISSN  0008-543X

　概要を見る

BACKGROUND: It is not rare to find satellite lesions in patients with small hepatocellular carcinoma (HCC). The purpose of this study was to elucidate the factors associated with satellite lesions in these patients. METHODS: We investigated the prevalence of satellite lesions, the relationship of clinicopathologic factors to satellite lesions, and the distance from the main tumor to the satellite lesion in 149 patients. Patients, who had a solitary HCC of 3.0 cm or less in diameter but no satellite lesions on preoperative imaging procedures, underwent potentially curative resection. The main tumors were macroscopically classified into four groups: early HCC, a vaguely nodular type showing preservation of the preexisting liver structure; single nodular type; single nodular type with extranodular growth; and confluent multinodular type. RESULTS: Of 149 resected specimens, 28 (19%) showed satellite lesions. Of the clinicopathologic factors investigated, the macroscopic type and tumor differentiation were significantly associated with the prevalence of satellite lesions. Both the single nodular type with extranodular growth and the confluent multinodular type showed satellite lesions more frequently than the early HCC and the single nodular type. A significantly higher prevalence of satellite lesions was observed in poorly differentiated HCC than in well and moderately differentiated HCC. The satellite lesions were located 0.5 cm or less from the main tumor in 8 (33%) specimens, 0.6-1.0 cm in 12 (50%), and 1.1-2.0 cm in 4 (17%). No identifiable factors were significantly related to the distance from the main tumor to the satellite lesion. However, all satellite lesions located more than 1.0 cm from the main tumor coexisted with poorly differentiated HCC, which were the single nodular type with extranodular growth or the confluent multinodular type. CONCLUSION: In the single nodular type with extranodular growth, confluent multinodular type, and poorly differentiated HCC, extensive treatment achieving a large safety margin and/or frequent posttreatment follow-up examinations may be needed because of the high prevalence of satellite lesions.

• Access to Document (DOI)

Satellite lesions in patientswith small hepatocellular carcinoma with reference to clinicopathologic features

Okusaka Takuji, Okada Shuichi, Ueno Hideki, Ikeda Masafumi Shimada Kazuaki, Yamamoto Junji, Kosuge Tomoo, Yamazaki Susumu, Fukushima Noriyuki, Sakamoto Michiie

Cancer 95 （ 9 ） 1931-1937 2002年11月

研究論文（学術雑誌）, 共著

Minute pancreatic adenocarcinoma presenting with stenosis of the main pancreatic duct

Yachida Shinichi, Fukushima Noriyoshi, Nakanishi Kazuaki, Shimada Kazuaki, Kosuge Tomoo, Sakamoto Michiie

Pathology international 52 （ 9 ） 607-611 2002年09月

研究論文（学術雑誌）, 共著

β-catenin mutations in sporadic fundic gland polyps

Sekine Shigeki, Shibata Tatsuhiro, Yamauchi Yuko, Nakanishi Yukihiro, Shimoda Tadakazu, Sakamoto Michiie, Hirohashi Setsuo

Virchows Archiv 440 （ 4 ） 381-386 2002年09月

研究論文（学術雑誌）, 共著

Less aggressive features of colorectal cancer with liver metastases showing macroscopic intrabiliary extension

Kubo Makoto, Sakamoto Michiie, Fukushima Noriyoshi, Yachida Shinichi, Nakanishi Yukihiro, Shimoda Tadakazu, Yamamoto Junji, Moriya Yoshihiro, Hirohashi S

Pathology international 52 （ 8 ） 514-518 2002年08月

研究論文（学術雑誌）, 共著

Clinicopathological Siginificance of Galectin-3 Expression in Ductal Adenocarcinoma of the Pancreas

Shimamura Takeshi, Sakamoto Michiie, Ino Yoshinori, Shimada Kazuaki, Kosuge Tomoo, Sato Yasuto, Tanaka Katsuaki, Sekihira Hisahiko, Hirohashi Setsuo

Clinical cancer research 8 （ 8 ） 2570-2575 2002年08月

研究論文（学術雑誌）, 共著

Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct:a Case Report

Yachida Shinichi, Fukushima Noriyoshi, Kanai Yae, Nimura Satoshi, Shimada Kazuaki, Yamamoto Junji, Sakamoto Michiie

Japanese journal of clinical oncology 32 （ 8 ） 315-317 2002年08月

研究論文（学術雑誌）, 共著

Target disruption of the mutantβ-Catenin gene in colon cancer cell line HCT116:preservation of its malignant phenotype

Sekine Shigeki, Shibata Tatsuhiro, Sakamoto Michiie, Hirohashi Setsuo

Oncogene 21 （ 38 ） 5906-5911 2002年08月

研究論文（学術雑誌）, 共著