論文 - 坂元　亨宇

Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization:Identification of genetic indicators to predict patient outcome:

坂元 亨宇

Journal hepatology. 43   863-874. 2005年

研究論文（学術雑誌）, 共著

Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma

Chuma, M., Sakamoto, M., Yasuda, J., Fujii, G., Nakanishi, K., Tsuchiya, A., Ohta, T., Asaka, M. and Hirohashi, S.

Journal of Hepatology 41 （ 4 ） 629 - 636 2004年10月

ISSN  0168-8278

　概要を見る

Background/Aims: The molecular basis of the metastasis of hepatocellular carcinoma (HCC) is not fully understood. The aim of this study was to elucidate the crucial genes involved in metastasis of HCC.

• Access to Document (DOI)

Orthotopic Transplantation Models of Pancreatic Adenocaricinoma Derived From Cell Lines and Primary Tumors and displaying barying metastatic activity;

坂元 亨宇

pancreatic cancer orthotopic models 29 （ 3 ） 2004 2004年10月

研究論文（学術雑誌）, 共著

Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis

Chuma, M., Saeki, N., Yamamoto, Y., Ohta, T., Asaka, M., Hirohashi, S. and Sakamoto, M.

Keio J Med 53 （ 2 ） 90 - 7 2004年06月

ISSN  0022-9717

　概要を見る

Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. To investigate the detailed genetic mechanisms in cancer metastasis, we compared the expression profiles of 20 HCCs with intrahepatic metastasis and 10 HCCs without intrahepatic metastasis using an oligonucleotide array. Of the approximately 12,600 genes that were analyzed, we identified 34 genes whose expression levels were significantly correlated with intrahepatic metastasis (P<0:05). Of these genes, we further investigated the expression of high-mobility group I(Y) [HMG-I(Y)] protein. Real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) confirmed that HMG-I(Y) was upregulated in HCC with intrahepatic metastasis, compared to its level in HCC without intrahepatic metastasis. Further immunohistochemical examination of HMG-I(Y) revealed a significant overexpression in HCC with intrahepatic metastasis, compared with that in HCC without intrahepatic metastasis (P<0:05). These results indicate that the molecular signatures of HCC with intrahepatic metastasis and of HCC without intrahepatic metastasis are clearly different. HMG-I(Y) expression was associated with intrahepatic metastasis and may be a predictive marker of HCC intrahepatic metastasis.

Can the life span of human marrow stromal cells be prolonged by bmi-1 E6,E7and/or telomerase without affecting cardiomyogenic defferentiation ;

坂元 亨宇

J.Gene Med. 0   833-845 2004年06月

研究論文（学術雑誌）, 単著

肝門部胆管癌進展様式の病理学的特徴：肝門部胆管癌の進展度診断−画像でどこまでわかるか：

尾島　英知　坂元　亨宇

医学書院 2004年05月

研究論文（学術雑誌）, 共著

Clinical significance of dysadherin expression in gastric cancer patients;

'Shimada Y, Yamasaki S, Hashimoto Y, Ito T, Kawamura J, Soma T, Ino Y, Nakamnishi Y, Sakamoto Michiie, Hirohashi Setsuo, Imamura M'

clinical cancer research 2818 （ 10 ） 2818-2823 2004年04月

研究論文（学術雑誌）, 単著

肝細胞癌の多段階発癌とフェノタイプ、

森　泰昌　柴田　理恵　杜　&#38639;林　坂元　亨宇：

肝胆膵 48 （ 4 ） 2004 2004年04月

研究論文（学術雑誌）, 共著

肝細胞癌の病理　肝細胞性結節性病変の鑑別を中心に　：

柴田　理恵　杜　&#38639;林　坂元　亨宇

臨床放射線 49 （ 11 ）  2004年

研究論文（学術雑誌）, 共著

Pedunculated　 angiomyolipoma of the liver with a predominant pelioid pattern

'Akatsu Tomotaka, Sakamoto Michiie, Shimazu M, Kitajima Masaki'

Virchows Archiv    444;467-469 2004年

研究論文（学術雑誌）, 単著

Tumor angiogenesis in the bone marrow of multiple myeloma patients and its alteration by thalidomide treatment

'Wenlin Du, Hattori Y, Hashiguchi Akinorik, Kondoh Keisuke, Hozumi Nobumichi, Ikeda Y, Sakamoto Michiie, Hata Junichi, Yamada Taketo'

pathology International  （ 54 ） 285-294 2004年

研究論文（学術雑誌）, 単著

Cusom-shaping system gor bon eregeneration by seeding marrow stromal cells onto a web-like biodegradable hybrid sheet

坂元 亨宇

Cell Tissue Research  （ 316 ） 141-153 2004年

研究論文（学術雑誌）, 単著

5-Aza-2’-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis;

'J-S-Nam, Ino Y, kanai Yae, Sakamoto Michiie, Hirohashi Setsuo'

Clnical&Experimental Metastasis 21   29-56 2004年

研究論文（学術雑誌）, 単著

Expression profiling in hepatocellular carcinoma with intrahepatic metastasis identification of high-mobility groupⅠ(Y)protein as a molecular marker of hepatocellular carcinoma metastasis

坂元 亨宇

Keio Journal of Medicine, l53 （ 2 ） 90-97 2004年

研究論文（学術雑誌）, 共著

Can the life span of human marrow stromal cells be prolonged by bmi-1 E6,E7and/or telomerase without affecting cardiomyogenic defferentiation ;J

坂元 亨宇

Gene Med. 6   833-845 2004年

研究論文（学術雑誌）, 共著

Lamin 5β3 and γ2 chains are frequently coexpressed in cancer cells;

坂元 亨宇

Pathology International 54   688-692 2004年

研究論文（学術雑誌）, 共著

Dysadherin expression facilitates cell motility and metastatic potential human pancreatic cancer cells;

坂元 亨宇

cancer research 64   6989-6995, 2004年

研究論文（学術雑誌）, 共著

Prognostic significance of deysadherin expression in esophageal squamous cell carcinoma;

坂元 亨宇

oncology 67   73-80 2004年

研究論文（学術雑誌）, 共著

High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient,with special reference to APC mutation profiles.

坂元 亨宇

Modern Pathology, 17   1421-1426 2004年

研究論文（学術雑誌）, 共著

Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.

坂元 亨宇

Journal of Hepatology. 41   626-636 2004年

研究論文（学術雑誌）, 共著